LPXN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.94750674
2positive regulation of gamma-delta T cell activation (GO:0046645)5.55081832
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.44904076
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.44904076
5modulation by symbiont of host immune response (GO:0052553)5.44904076
6positive regulation by symbiont of host defense response (GO:0052509)5.44904076
7modulation by symbiont of host defense response (GO:0052031)5.44904076
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.44904076
9antigen processing and presentation of endogenous antigen (GO:0019883)5.16654618
10* regulation of B cell receptor signaling pathway (GO:0050855)5.14129688
11regulation of interferon-beta biosynthetic process (GO:0045357)5.10229883
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.86885997
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.86885997
14immunoglobulin mediated immune response (GO:0016064)4.43499402
15negative regulation of cell killing (GO:0031342)4.39530499
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.39530499
17B cell receptor signaling pathway (GO:0050853)4.38017625
18positive regulation of interferon-alpha production (GO:0032727)4.34797770
19positive thymic T cell selection (GO:0045059)4.33401543
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.32568189
21negative thymic T cell selection (GO:0045060)4.31599803
22regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.30695084
23negative T cell selection (GO:0043383)4.29492405
24negative regulation of interleukin-12 production (GO:0032695)4.21805309
25regulation of interferon-alpha production (GO:0032647)4.19632465
26neutrophil activation involved in immune response (GO:0002283)4.16460370
27regulation of gamma-delta T cell differentiation (GO:0045586)4.11091533
28T cell migration (GO:0072678)4.04801030
29positive regulation of antigen processing and presentation (GO:0002579)3.98642337
30macrophage activation involved in immune response (GO:0002281)3.91064051
31regulation of gamma-delta T cell activation (GO:0046643)3.90847358
32tolerance induction (GO:0002507)3.86374832
33leukocyte aggregation (GO:0070486)3.81467668
34Arp2/3 complex-mediated actin nucleation (GO:0034314)3.74421690
35regulation of interleukin-12 biosynthetic process (GO:0045075)3.74292000
36NIK/NF-kappaB signaling (GO:0038061)3.69609791
37mast cell activation (GO:0045576)3.63003260
38regulation of B cell differentiation (GO:0045577)3.60992554
39positive regulation of B cell differentiation (GO:0045579)3.60291800
40thymic T cell selection (GO:0045061)3.60051559
41cellular response to interleukin-15 (GO:0071350)3.55098581
42myeloid cell activation involved in immune response (GO:0002275)3.55023373
43response to interleukin-15 (GO:0070672)3.52871696
44interferon-gamma production (GO:0032609)3.51587339
45regulation of interleukin-2 biosynthetic process (GO:0045076)3.51052646
46positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.50176245
47B cell mediated immunity (GO:0019724)3.50089446
48respiratory burst (GO:0045730)3.49400775
49positive T cell selection (GO:0043368)3.45265945
50* regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.42847729
51cellular response to zinc ion (GO:0071294)3.42496133
52regulation of antigen processing and presentation (GO:0002577)3.41699527
53pinocytosis (GO:0006907)3.40574236
54cytidine metabolic process (GO:0046087)3.39234787
55cytidine catabolic process (GO:0006216)3.39234787
56cytidine deamination (GO:0009972)3.39234787
57positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.38152356
58interferon-gamma-mediated signaling pathway (GO:0060333)3.36772505
59response to peptidoglycan (GO:0032494)3.34084041
60response to host immune response (GO:0052572)3.33594851
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.33594851
62type I interferon signaling pathway (GO:0060337)3.33119148
63cellular response to type I interferon (GO:0071357)3.33119148
64microglial cell activation (GO:0001774)3.32869121
65response to type I interferon (GO:0034340)3.32309919
66negative regulation of T cell mediated immunity (GO:0002710)3.30588698
67T cell selection (GO:0045058)3.25093279
68defense response to protozoan (GO:0042832)3.21010547
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.20816240
70lipopolysaccharide-mediated signaling pathway (GO:0031663)3.20424341
71cellular extravasation (GO:0045123)3.20161779
72antigen receptor-mediated signaling pathway (GO:0050851)3.18613736
73regulation of tolerance induction (GO:0002643)3.18031793
74regulation of T cell tolerance induction (GO:0002664)3.17679845
75regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.14532015
76regulation of natural killer cell mediated immunity (GO:0002715)3.14532015
77T cell costimulation (GO:0031295)3.12608090
78response to muramyl dipeptide (GO:0032495)3.10379262
79regulation of isotype switching to IgG isotypes (GO:0048302)3.09318317
80neutrophil activation (GO:0042119)3.09175017
81positive regulation of interferon-beta production (GO:0032728)3.08536324
82positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.08533662
83detection of other organism (GO:0098543)3.08126127
84lymphocyte costimulation (GO:0031294)3.07850059
85granulocyte activation (GO:0036230)3.07347917
86regulation of alpha-beta T cell proliferation (GO:0046640)3.06278074
87response to host (GO:0075136)3.06210947
88response to host defenses (GO:0052200)3.06210947
89response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.06210947
90positive regulation of mast cell activation (GO:0033005)3.05866816
91regulation of dendritic cell antigen processing and presentation (GO:0002604)3.05750054
92myeloid dendritic cell activation (GO:0001773)3.04681046
93regulation of T cell receptor signaling pathway (GO:0050856)3.04670698
94positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.04391195
95positive regulation of macrophage differentiation (GO:0045651)3.04315631
96positive regulation of isotype switching (GO:0045830)3.04168887
97detection of bacterium (GO:0016045)3.03725904
98positive regulation of interleukin-2 production (GO:0032743)3.03266554
99lymphocyte chemotaxis (GO:0048247)3.02023354
100germinal center formation (GO:0002467)3.00838483
101natural killer cell mediated immunity (GO:0002228)2.98428635
102natural killer cell mediated cytotoxicity (GO:0042267)2.98428635
103lymphocyte migration (GO:0072676)2.97843565
104regulation of T cell mediated cytotoxicity (GO:0001914)2.97586122
105response to protozoan (GO:0001562)2.95311107
106sequestering of actin monomers (GO:0042989)2.92976277
107regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.92489426
108regulation of T-helper 1 cell differentiation (GO:0045625)2.91959850
109positive regulation of immunoglobulin mediated immune response (GO:0002891)2.91564695
110positive regulation of B cell mediated immunity (GO:0002714)2.91564695
111* negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.91314020
112cellular response to interferon-gamma (GO:0071346)2.90384336
113mature B cell differentiation (GO:0002335)2.90186695
114regulation of regulatory T cell differentiation (GO:0045589)2.89726955
115actin nucleation (GO:0045010)2.89533094
116T cell receptor signaling pathway (GO:0050852)2.89180555
117negative regulation of lymphocyte mediated immunity (GO:0002707)2.88004535
118myeloid dendritic cell differentiation (GO:0043011)2.87597921
119B cell homeostasis (GO:0001782)2.87331394
120regulation of vitamin D biosynthetic process (GO:0060556)2.87240352
121regulation of type I interferon-mediated signaling pathway (GO:0060338)2.86885841
122regulation of response to interferon-gamma (GO:0060330)2.86525788
123positive regulation of alpha-beta T cell proliferation (GO:0046641)2.84580309
124positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.83931755
125myeloid leukocyte activation (GO:0002274)2.83644716
126macrophage activation (GO:0042116)2.83629261
127negative regulation of leukocyte mediated immunity (GO:0002704)2.81547535
128regulation of leukocyte mediated cytotoxicity (GO:0001910)2.80741688

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.06235098
2* IRF8_21731497_ChIP-ChIP_J774_Mouse5.42794006
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.35860887
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.73992117
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.11069874
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.03538782
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.79543488
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44743823
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40312511
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.36542780
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.23110883
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.17609068
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15245066
14* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.99579845
15E2F7_22180533_ChIP-Seq_HELA_Human2.87111702
16MYB_26560356_Chip-Seq_TH2_Human2.58047547
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53774829
18MYC_22102868_ChIP-Seq_BL_Human2.47566946
19RUNX_20019798_ChIP-Seq_JUKART_Human2.47389101
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.44607005
21* SPI1_23547873_ChIP-Seq_NB4_Human2.40472437
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.40036767
23MAF_26560356_Chip-Seq_TH1_Human2.34938574
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23064936
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19961058
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19489787
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18467849
28MYB_26560356_Chip-Seq_TH1_Human2.17077178
29VDR_21846776_ChIP-Seq_THP-1_Human2.16942277
30* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.16352933
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.14563459
32BRD4_27068464_Chip-Seq_AML-cells_Mouse2.11604785
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.06615022
34UTX_26944678_Chip-Seq_JUKART_Human1.94438198
35VDR_24763502_ChIP-Seq_THP-1_Human1.93920741
36SCL_19346495_ChIP-Seq_HPC-7_Human1.85306253
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84537071
38* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82694124
39SPI1_23127762_ChIP-Seq_K562_Human1.79612034
40* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76067366
41* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70003255
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.68865604
43PU_27001747_Chip-Seq_BMDM_Mouse1.64963126
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63393884
45* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62619134
46* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58158258
47* GATA3_27048872_Chip-Seq_THYMUS_Human1.56362562
48MAF_26560356_Chip-Seq_TH2_Human1.55044173
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46319160
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43581100
51* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43214096
52TCF7_22412390_ChIP-Seq_EML_Mouse1.42396625
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41787887
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.38880074
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31502161
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27509224
57* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25461848
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25022243
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22838841
60GATA3_26560356_Chip-Seq_TH2_Human1.22169272
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.18787979
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18642666
63VDR_24787735_ChIP-Seq_THP-1_Human1.16774689
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15574271
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13088528
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12743413
67* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11924877
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08460339
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07395926
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04088008
71KDM2B_26808549_Chip-Seq_DND41_Human1.03946187
72TFEB_21752829_ChIP-Seq_HELA_Human1.03194344
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02228243
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02069739
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00513312
76PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99061464
77BCL6_27268052_Chip-Seq_Bcells_Human0.98189616
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98147194
79ELK3_25401928_ChIP-Seq_HUVEC_Human0.97337343
80* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96810481
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96682646
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95140088
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95002721
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94803998
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91105047
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90021853
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85579395
88GATA2_21666600_ChIP-Seq_HMVEC_Human0.84379504
89VDR_23849224_ChIP-Seq_CD4+_Human0.83819108
90VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83539848
91BCOR_27268052_Chip-Seq_Bcells_Human0.82865483
92GATA1_19941827_ChIP-Seq_MEL_Mouse0.82449523
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.81453580
94SPI1_20517297_ChIP-Seq_HL60_Human0.79291227
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.79261902
96E2F4_17652178_ChIP-ChIP_JURKAT_Human0.77298636
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75913274
98GATA1_19941826_ChIP-Seq_K562_Human0.74075593
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73908525
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.72540501
101GATA1_22025678_ChIP-Seq_K562_Human0.70127193
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.69507501
103* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68647230
104* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68019160
105LXR_22292898_ChIP-Seq_THP-1_Human0.66439625
106FOXP3_21729870_ChIP-Seq_TREG_Human0.65031738
107RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64882440
108ELK1_19687146_ChIP-ChIP_HELA_Human0.64333683
109CIITA_25753668_ChIP-Seq_RAJI_Human0.62216693
110CTCF_26484167_Chip-Seq_Bcells_Mouse0.61524348
111ETS1_22383799_ChIP-Seq_G1ME_Mouse0.60847929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.84366859
2MP0005671_abnormal_response_to3.74197597
3MP0001800_abnormal_humoral_immune3.39011987
4MP0005387_immune_system_phenotype3.35223240
5MP0001790_abnormal_immune_system3.35223240
6MP0005000_abnormal_immune_tolerance3.32082735
7MP0003436_decreased_susceptibility_to3.28410850
8MP0006082_CNS_inflammation3.20637530
9MP0003303_peritoneal_inflammation3.09147970
10MP0000685_abnormal_immune_system3.07472947
11MP0002452_abnormal_antigen_presenting3.05780817
12MP0009785_altered_susceptibility_to2.95712084
13MP0002723_abnormal_immune_serum2.89771757
14MP0002148_abnormal_hypersensitivity_rea2.82052220
15MP0005058_abnormal_lysosome_morphology2.81349588
16MP0002419_abnormal_innate_immunity2.80723493
17MP0002420_abnormal_adaptive_immunity2.77775919
18MP0001819_abnormal_immune_cell2.74984498
19MP0005025_abnormal_response_to2.74227729
20MP0003763_abnormal_thymus_physiology2.67928011
21MP0004510_myositis2.32810174
22MP0002398_abnormal_bone_marrow2.31146440
23MP0002405_respiratory_system_inflammati2.28140455
24MP0000716_abnormal_immune_system2.20894777
25MP0003300_gastrointestinal_ulcer2.10750424
26MP0009333_abnormal_splenocyte_physiolog2.09165996
27MP0003172_abnormal_lysosome_physiology2.09018789
28MP0000689_abnormal_spleen_morphology2.06521529
29MP0002166_altered_tumor_susceptibility2.04648053
30MP0005464_abnormal_platelet_physiology2.02792355
31MP0003724_increased_susceptibility_to1.93081514
32MP0002722_abnormal_immune_system1.89444945
33MP0001845_abnormal_inflammatory_respons1.88903438
34MP0004947_skin_inflammation1.86958092
35MP0002429_abnormal_blood_cell1.81804493
36MP0010155_abnormal_intestine_physiology1.78913569
37MP0001853_heart_inflammation1.71651193
38MP0005310_abnormal_salivary_gland1.71190242
39MP0001873_stomach_inflammation1.71075335
40MP0001533_abnormal_skeleton_physiology1.66644377
41MP0002006_tumorigenesis1.65744229
42MP0002933_joint_inflammation1.65741304
43MP0003448_altered_tumor_morphology1.52760262
44MP0000703_abnormal_thymus_morphology1.52640124
45MP0008469_abnormal_protein_level1.50256692
46MP0009840_abnormal_foam_cell1.47945822
47MP0005451_abnormal_body_composition1.43742823
48MP0000465_gastrointestinal_hemorrhage1.35896045
49MP0003191_abnormal_cellular_cholesterol1.35119830
50MP0000858_altered_metastatic_potential1.34019020
51MP0002396_abnormal_hematopoietic_system1.30548231
52MP0000604_amyloidosis1.30538669
53MP0000343_altered_response_to1.29379501
54MP0003866_abnormal_defecation1.27562232
55MP0010307_abnormal_tumor_latency1.26348562
56MP0002998_abnormal_bone_remodeling1.18101036
57MP0005174_abnormal_tail_pigmentation1.13791304
58MP0000569_abnormal_digit_pigmentation1.08364514
59MP0005166_decreased_susceptibility_to1.03344683
60MP0004808_abnormal_hematopoietic_stem1.02216919
61MP0009764_decreased_sensitivity_to1.01956230
62MP0003183_abnormal_peptide_metabolism1.01258553
63MP0001851_eye_inflammation1.00304253
64MP0000490_abnormal_crypts_of0.98058015
65MP0003806_abnormal_nucleotide_metabolis0.97840823
66MP0003690_abnormal_glial_cell0.92465584
67MP0005397_hematopoietic_system_phenotyp0.91457981
68MP0001545_abnormal_hematopoietic_system0.91457981
69MP0000015_abnormal_ear_pigmentation0.88465305
70MP0002877_abnormal_melanocyte_morpholog0.85710182
71MP0009763_increased_sensitivity_to0.84039578
72MP0002139_abnormal_hepatobiliary_system0.82417733
73MP0002138_abnormal_hepatobiliary_system0.82015730
74MP0005076_abnormal_cell_differentiation0.81059004
75MP0002019_abnormal_tumor_incidence0.80989920
76MP0009278_abnormal_bone_marrow0.80716472
77MP0008260_abnormal_autophagy0.80187893
78MP0003075_altered_response_to0.79395898
79MP0004381_abnormal_hair_follicle0.75933775
80MP0002277_abnormal_respiratory_mucosa0.75723540
81MP0002132_abnormal_respiratory_system0.75597717
82MP0002136_abnormal_kidney_physiology0.74024212
83MP0003566_abnormal_cell_adhesion0.68242972
84MP0000249_abnormal_blood_vessel0.67053285
85MP0003795_abnormal_bone_structure0.66733118
86MP0004883_abnormal_blood_vessel0.65996253
87MP0003045_fibrosis0.64900905
88MP0005390_skeleton_phenotype0.64478321
89MP0005164_abnormal_response_to0.64131254
90MP0005167_abnormal_blood-brain_barrier0.63719417
91MP0003828_pulmonary_edema0.60802846
92MP0000609_abnormal_liver_physiology0.57841263
93MP0005023_abnormal_wound_healing0.56320227
94MP0001663_abnormal_digestive_system0.55772754
95MP0002254_reproductive_system_inflammat0.55110534
96MP0008057_abnormal_DNA_replication0.54760548
97MP0000371_diluted_coat_color0.54203239
98MP0008873_increased_physiological_sensi0.53284980
99MP0005075_abnormal_melanosome_morpholog0.53257020
100MP0002693_abnormal_pancreas_physiology0.52349355
101MP0008004_abnormal_stomach_pH0.51980643
102MP0003656_abnormal_erythrocyte_physiolo0.51919845
103MP0008874_decreased_physiological_sensi0.49743302
104MP0010352_gastrointestinal_tract_polyps0.48529933
105MP0002332_abnormal_exercise_endurance0.48074094
106MP0003091_abnormal_cell_migration0.47708529
107MP0000598_abnormal_liver_morphology0.47283370
108MP0000313_abnormal_cell_death0.45835339
109MP0003077_abnormal_cell_cycle0.45365709
110MP0008007_abnormal_cellular_replicative0.45075062
111MP0010094_abnormal_chromosome_stability0.44467992
112MP0002135_abnormal_kidney_morphology0.43450115
113MP0003453_abnormal_keratinocyte_physiol0.43099509
114MP0009765_abnormal_xenobiotic_induced0.42290181
115MP0000920_abnormal_myelination0.41504964

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.03256942
2Eczematoid dermatitis (HP:0000976)5.29534051
3Recurrent bacterial skin infections (HP:0005406)5.11612351
4Recurrent bronchitis (HP:0002837)4.34220185
5Myositis (HP:0100614)4.28698327
6Elevated erythrocyte sedimentation rate (HP:0003565)4.27532089
7Vacuolated lymphocytes (HP:0001922)4.24980166
8Increased cerebral lipofuscin (HP:0011813)4.22466754
9Recurrent fungal infections (HP:0002841)4.08368769
10IgM deficiency (HP:0002850)3.93241438
11Autoimmune hemolytic anemia (HP:0001890)3.90493348
12Recurrent gram-negative bacterial infections (HP:0005420)3.87392771
13Recurrent viral infections (HP:0004429)3.84568648
14Abnormality of macrophages (HP:0004311)3.83853247
15Systemic lupus erythematosus (HP:0002725)3.82080113
16Recurrent skin infections (HP:0001581)3.80671198
17Stomatitis (HP:0010280)3.78803260
18Abnormality of T cell number (HP:0011839)3.75721160
19T lymphocytopenia (HP:0005403)3.75648542
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.71993316
21Agammaglobulinemia (HP:0004432)3.67124924
22Chronic obstructive pulmonary disease (HP:0006510)3.65668650
23Obstructive lung disease (HP:0006536)3.65668650
24Mediastinal lymphadenopathy (HP:0100721)3.65227720
25Recurrent cutaneous fungal infections (HP:0011370)3.60560842
26Chronic mucocutaneous candidiasis (HP:0002728)3.60560842
27Autoimmune thrombocytopenia (HP:0001973)3.51203478
28Vasculitis (HP:0002633)3.50265814
29Orchitis (HP:0100796)3.45343402
30Retrobulbar optic neuritis (HP:0100654)3.43985121
31Optic neuritis (HP:0100653)3.43985121
32Meningitis (HP:0001287)3.43196454
33Chronic otitis media (HP:0000389)3.42925665
34Inflammation of the large intestine (HP:0002037)3.40019131
35Abnormality of T cells (HP:0002843)3.28500905
36Gastrointestinal inflammation (HP:0004386)3.23540916
37Pustule (HP:0200039)3.23478280
38Gastrointestinal stroma tumor (HP:0100723)3.21380509
39Cellulitis (HP:0100658)3.21328095
40Disinhibition (HP:0000734)3.20796841
41Abnormality of glycolipid metabolism (HP:0010969)3.20343999
42Abnormality of liposaccharide metabolism (HP:0010968)3.20343999
43Abnormality of glycosphingolipid metabolism (HP:0004343)3.20343999
44Dysostosis multiplex (HP:0000943)3.20087455
45IgG deficiency (HP:0004315)3.17321399
46Colitis (HP:0002583)3.16010421
47Gastrointestinal infarctions (HP:0005244)3.12627965
48Recurrent sinusitis (HP:0011108)3.11943683
49Gingivitis (HP:0000230)3.09305119
50Lymphopenia (HP:0001888)3.05599138
51Nasal polyposis (HP:0100582)3.02936864
52Severe combined immunodeficiency (HP:0004430)2.98936187
53Abnormal delayed hypersensitivity skin test (HP:0002963)2.98244167
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.98017069
55Combined immunodeficiency (HP:0005387)2.96751879
56Thyroiditis (HP:0100646)2.88415441
57Panhypogammaglobulinemia (HP:0003139)2.87730060
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.87375373
59Agnosia (HP:0010524)2.83552282
60Chronic diarrhea (HP:0002028)2.82281603
61Pulmonary infiltrates (HP:0002113)2.79444131
62Recurrent pneumonia (HP:0006532)2.78243142
63Abnormality of T cell physiology (HP:0011840)2.77590493
64IgA deficiency (HP:0002720)2.76094421
65Chest pain (HP:0100749)2.72287272
66Granulocytopenia (HP:0001913)2.69522883
67Leukocytosis (HP:0001974)2.67810280
68Basal ganglia calcification (HP:0002135)2.64249285
69Recurrent lower respiratory tract infections (HP:0002783)2.64174933
70Osteomyelitis (HP:0002754)2.63697567
71Glomerulonephritis (HP:0000099)2.63189495
72Abnormality of the nasal mucosa (HP:0000433)2.54070361
73Emphysema (HP:0002097)2.50089498
74Petechiae (HP:0000967)2.47846526
75Mucopolysacchariduria (HP:0008155)2.47652451
76Urinary glycosaminoglycan excretion (HP:0003541)2.47652451
77Spontaneous hematomas (HP:0007420)2.46066473
78Keratoconjunctivitis (HP:0001096)2.45663807
79Bronchitis (HP:0012387)2.43542566
80Increased IgM level (HP:0003496)2.43253634
81Arterial thrombosis (HP:0004420)2.41358478
82Loss of speech (HP:0002371)2.41274231
83Gangrene (HP:0100758)2.40578956
84Chronic sinusitis (HP:0011109)2.39331232
85Abnormality of eosinophils (HP:0001879)2.39279441
86Encephalitis (HP:0002383)2.37134942
87Axonal loss (HP:0003447)2.34009157
88Abnormality of the prostate (HP:0008775)2.33891785
89Eosinophilia (HP:0001880)2.32135979
90Abnormality of polysaccharide metabolism (HP:0011012)2.31656350
91Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31656350
92Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31656350
93Keratoconjunctivitis sicca (HP:0001097)2.31517331
94Pulmonary embolism (HP:0002204)2.31345551
95Interstitial pulmonary disease (HP:0006530)2.30475033
96Hypergammaglobulinemia (HP:0010702)2.29888348
97Hepatosplenomegaly (HP:0001433)2.27125318
98Polyneuropathy (HP:0001271)2.26482012
99Hemoptysis (HP:0002105)2.26407858
100B lymphocytopenia (HP:0010976)2.26170533
101Abnormality of B cell number (HP:0010975)2.26170533
102Periodontitis (HP:0000704)2.25833402
103Abnormality of the pleura (HP:0002103)2.25729073
104Verrucae (HP:0200043)2.24465840
105Papilloma (HP:0012740)2.24465840
106Myocardial infarction (HP:0001658)2.24024194
107Lymphoma (HP:0002665)2.20919163
108Joint swelling (HP:0001386)2.20904192
109Restrictive lung disease (HP:0002091)2.20461031
110Urticaria (HP:0001025)2.20191072
111Increased IgE level (HP:0003212)2.19292559
112Glomerulopathy (HP:0100820)2.13651478
113Epistaxis (HP:0000421)2.12611048
114Pulmonary fibrosis (HP:0002206)2.12608085
115Skin rash (HP:0000988)2.09474721
116Amaurosis fugax (HP:0100576)2.08852320
117Increased serum ferritin (HP:0003281)2.06415498
118Premature loss of primary teeth (HP:0006323)2.05482094
119Arthralgia (HP:0002829)2.05149012
120Sepsis (HP:0100806)2.04185714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.32172208
2TXK3.69395096
3BLK3.58706694
4TYK23.23964845
5KIT2.88168681
6MAP3K142.79703211
7TBK12.72283766
8ZAP702.63957368
9PRPF4B2.34282618
10IKBKE2.31637004
11JAK12.28391314
12SYK2.23253259
13ITK2.22261921
14IRAK42.20034109
15JAK32.18204148
16CSF1R2.10252967
17RIPK41.97371896
18IRAK31.95539651
19STK101.94891173
20TESK21.83254792
21GRK61.80584655
22BTK1.78270284
23IKBKB1.77725564
24ERN11.75561637
25LCK1.69134476
26TGFBR21.66474152
27BMPR21.64960297
28CSK1.62386766
29HCK1.62331732
30TEC1.57288049
31NME21.48862123
32FGFR41.44801914
33FES1.39904319
34MST41.38988501
35* LYN1.35885058
36TAOK31.28680774
37TAOK21.28235587
38MAP3K131.25867210
39NEK91.18551932
40FGFR31.16478844
41LRRK21.12366808
42CLK11.12081049
43SCYL21.07977929
44KDR1.06713496
45PIM11.02087309
46JAK20.95267124
47PKN20.94870159
48PRKCQ0.94760903
49PIM20.93258777
50RPS6KA40.92391854
51MAP2K30.90955360
52MAP3K100.90226027
53PRKCH0.90044404
54CHUK0.89835949
55TESK10.86418602
56SIK20.83624452
57CAMKK20.83322931
58TAOK10.79068495
59EPHB10.77772706
60MOS0.76283130
61MARK30.74696495
62PIK3CG0.72048658
63CDC42BPA0.65887478
64TRIB30.65325331
65MAP3K10.64344589
66FGR0.63364057
67PASK0.62337361
68MAPK70.60385886
69PRKCD0.59158165
70NLK0.58782642
71EIF2AK30.56972952
72MAP3K120.54912378
73GRK70.54177374
74STK40.52030854
75PDK10.51571267
76DDR20.51553867
77TNK20.51481614
78ABL10.50988384
79ADRBK20.49433928
80EGFR0.47220988
81EEF2K0.45565641
82CDK60.45340148
83CAMKK10.44484778
84PAK40.44337080
85TTN0.42610743
86IRAK10.42474647
87MAPK120.42109716
88CDK120.41929508
89* FYN0.41833969
90ARAF0.40998891
91RIPK10.40316028
92EIF2AK10.39514009
93CDK40.38171638
94MAPK40.38162392
95MAPKAPK20.37036865
96NEK20.35759627
97MATK0.35748684
98INSR0.35515861
99PDPK10.34654104
100CAMK1D0.34388686
101SMG10.32568161
102ALK0.29507163
103PBK0.28304971
104MAP2K60.28110551
105RPS6KL10.27960812
106RPS6KC10.27960812
107PTK60.26269165
108MAP3K110.25705752
109MAP3K30.25641127
110STK240.25244859
111MAP3K80.23561267
112PRKD20.23358334
113TRPM70.23343078
114RPS6KA60.22809834
115PDGFRB0.22767677
116SIK30.22742525
117EPHA30.22714028
118EIF2AK20.21686297
119KSR20.21157902
120MAP3K50.20824312
121MELK0.20365122
122RPS6KA50.20350746
123* IGF1R0.19251100
124MAPK110.18389538
125HIPK20.17505139
126TLK10.15295888

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.94101501
2Leishmaniasis_Homo sapiens_hsa051402.81396900
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.80006746
4Antigen processing and presentation_Homo sapiens_hsa046122.78775104
5B cell receptor signaling pathway_Homo sapiens_hsa046622.65673639
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.61411025
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.59763666
8Osteoclast differentiation_Homo sapiens_hsa043802.57483091
9Staphylococcus aureus infection_Homo sapiens_hsa051502.55846248
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.52626749
11Graft-versus-host disease_Homo sapiens_hsa053322.49722169
12Measles_Homo sapiens_hsa051622.41431909
13Allograft rejection_Homo sapiens_hsa053302.34146658
14Lysosome_Homo sapiens_hsa041422.20650837
15T cell receptor signaling pathway_Homo sapiens_hsa046602.14988381
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.12270394
17Hematopoietic cell lineage_Homo sapiens_hsa046402.04316421
18Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02841460
19Other glycan degradation_Homo sapiens_hsa005112.00220039
20Tuberculosis_Homo sapiens_hsa051521.86768401
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72892807
22Asthma_Homo sapiens_hsa053101.65782084
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62709756
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61726249
25Pertussis_Homo sapiens_hsa051331.56280343
26Legionellosis_Homo sapiens_hsa051341.54850774
27Toxoplasmosis_Homo sapiens_hsa051451.49221762
28Viral myocarditis_Homo sapiens_hsa054161.46553035
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.46225847
30Herpes simplex infection_Homo sapiens_hsa051681.45281757
31Shigellosis_Homo sapiens_hsa051311.41238097
32Apoptosis_Homo sapiens_hsa042101.41084822
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40845689
34Autoimmune thyroid disease_Homo sapiens_hsa053201.40819703
35Malaria_Homo sapiens_hsa051441.40018043
36Influenza A_Homo sapiens_hsa051641.39898510
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39036172
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38714856
39Chemokine signaling pathway_Homo sapiens_hsa040621.35993930
40Rheumatoid arthritis_Homo sapiens_hsa053231.30295456
41Salmonella infection_Homo sapiens_hsa051321.28055568
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25115256
43Phagosome_Homo sapiens_hsa041451.17043113
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.11644811
45TNF signaling pathway_Homo sapiens_hsa046681.11037895
46Hepatitis B_Homo sapiens_hsa051611.10087155
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06643459
48Type I diabetes mellitus_Homo sapiens_hsa049400.96188025
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96102187
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93511907
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89014303
52Epstein-Barr virus infection_Homo sapiens_hsa051690.83494352
53Pancreatic cancer_Homo sapiens_hsa052120.81039348
54Hepatitis C_Homo sapiens_hsa051600.78348811
55DNA replication_Homo sapiens_hsa030300.75553972
56Base excision repair_Homo sapiens_hsa034100.72628781
57Acute myeloid leukemia_Homo sapiens_hsa052210.71590426
58Platelet activation_Homo sapiens_hsa046110.71331424
59Viral carcinogenesis_Homo sapiens_hsa052030.71310384
60Endocytosis_Homo sapiens_hsa041440.69060259
61Chronic myeloid leukemia_Homo sapiens_hsa052200.66641219
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64765539
63HTLV-I infection_Homo sapiens_hsa051660.61430057
64Caffeine metabolism_Homo sapiens_hsa002320.58846025
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58663466
66VEGF signaling pathway_Homo sapiens_hsa043700.57421260
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.56832120
68Mismatch repair_Homo sapiens_hsa034300.53418385
69p53 signaling pathway_Homo sapiens_hsa041150.46899207
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45119038
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44841681
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44470840
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.43380170
74African trypanosomiasis_Homo sapiens_hsa051430.42778269
75Proteasome_Homo sapiens_hsa030500.42449236
76Complement and coagulation cascades_Homo sapiens_hsa046100.41937593
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39477273
78Systemic lupus erythematosus_Homo sapiens_hsa053220.38484196
79Prolactin signaling pathway_Homo sapiens_hsa049170.38042459
80Collecting duct acid secretion_Homo sapiens_hsa049660.36557518
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35657420
82Bladder cancer_Homo sapiens_hsa052190.34213847
83Colorectal cancer_Homo sapiens_hsa052100.33995097
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33580542
85Non-homologous end-joining_Homo sapiens_hsa034500.33159218
86HIF-1 signaling pathway_Homo sapiens_hsa040660.31063031
87Homologous recombination_Homo sapiens_hsa034400.30657145
88Non-small cell lung cancer_Homo sapiens_hsa052230.30096527
89Small cell lung cancer_Homo sapiens_hsa052220.29464861
90Notch signaling pathway_Homo sapiens_hsa043300.26914618
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25858099
92Renal cell carcinoma_Homo sapiens_hsa052110.23719254
93Amoebiasis_Homo sapiens_hsa051460.23464115
94Sphingolipid metabolism_Homo sapiens_hsa006000.22952045
95Renin-angiotensin system_Homo sapiens_hsa046140.20103069
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.18525578
97Inositol phosphate metabolism_Homo sapiens_hsa005620.18377597
98Pentose phosphate pathway_Homo sapiens_hsa000300.17925244
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16539662
100Prion diseases_Homo sapiens_hsa050200.16285466
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16280680
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13669370
103Nucleotide excision repair_Homo sapiens_hsa034200.13518982
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12784212
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12415556
106MAPK signaling pathway_Homo sapiens_hsa040100.12300244
107Insulin resistance_Homo sapiens_hsa049310.11953575
108FoxO signaling pathway_Homo sapiens_hsa040680.10619120
109Dorso-ventral axis formation_Homo sapiens_hsa043200.10087978
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.09392410
111mTOR signaling pathway_Homo sapiens_hsa041500.07529306
112Prostate cancer_Homo sapiens_hsa052150.07286659
113Vibrio cholerae infection_Homo sapiens_hsa051100.03088737
114GnRH signaling pathway_Homo sapiens_hsa049120.02431323
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.01833480
116Type II diabetes mellitus_Homo sapiens_hsa049300.00789153

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