LRBA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.79753506
2nuclear pore organization (GO:0006999)6.62799394
3pore complex assembly (GO:0046931)5.54579933
4negative regulation of DNA repair (GO:0045738)4.62889094
5mitotic sister chromatid cohesion (GO:0007064)4.56323454
6regulation of RNA export from nucleus (GO:0046831)4.33646925
7peptidyl-lysine dimethylation (GO:0018027)4.20271939
8pre-miRNA processing (GO:0031054)4.12210728
9definitive hemopoiesis (GO:0060216)4.02380121
10regulation of histone H3-K9 methylation (GO:0051570)3.86899255
11determination of adult lifespan (GO:0008340)3.86550138
12biotin metabolic process (GO:0006768)3.86037403
13cytoplasmic mRNA processing body assembly (GO:0033962)3.77490026
14monoubiquitinated protein deubiquitination (GO:0035520)3.56716426
15regulation of nucleobase-containing compound transport (GO:0032239)3.52356531
16protein targeting to Golgi (GO:0000042)3.52343457
17positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.51489892
18iron ion import (GO:0097286)3.47588314
19regulation of pigment cell differentiation (GO:0050932)3.45125122
20retrograde transport, vesicle recycling within Golgi (GO:0000301)3.41867111
21establishment of protein localization to Golgi (GO:0072600)3.38604323
22positive regulation of developmental pigmentation (GO:0048087)3.37651757
23regulation of histone H3-K27 methylation (GO:0061085)3.35016081
24negative regulation of histone methylation (GO:0031061)3.32157889
25peptidyl-lysine trimethylation (GO:0018023)3.31750204
26embryonic retina morphogenesis in camera-type eye (GO:0060059)3.31597154
27cellular response to ethanol (GO:0071361)3.29568237
28positive regulation of histone deacetylation (GO:0031065)3.25792307
29protein K48-linked deubiquitination (GO:0071108)3.24137216
30embryonic process involved in female pregnancy (GO:0060136)3.20969608
31positive regulation of protein import into nucleus, translocation (GO:0033160)3.19689937
32DNA duplex unwinding (GO:0032508)3.18044681
33regulation of transforming growth factor beta2 production (GO:0032909)3.14766156
34regulation of bile acid biosynthetic process (GO:0070857)3.09810430
35intestinal absorption (GO:0050892)3.08903426
36regulation of centrosome duplication (GO:0010824)3.07979281
37intestinal epithelial cell development (GO:0060576)3.07930626
38regulation of centriole replication (GO:0046599)3.04208019
39DNA geometric change (GO:0032392)3.03910966
40regulation of establishment of cell polarity (GO:2000114)3.02135789
41peptidyl-lysine methylation (GO:0018022)3.01034498
42hepatocyte apoptotic process (GO:0097284)3.00819056
43genitalia morphogenesis (GO:0035112)2.98035413
44cilium or flagellum-dependent cell motility (GO:0001539)2.96721131
45intestinal cholesterol absorption (GO:0030299)2.96316811
46histone lysine methylation (GO:0034968)2.93326031
47relaxation of cardiac muscle (GO:0055119)2.93267132
48sphingosine metabolic process (GO:0006670)2.90212231
49NLS-bearing protein import into nucleus (GO:0006607)2.87596399
50regulation of histone H3-K4 methylation (GO:0051569)2.86147002
51histone H3-K36 demethylation (GO:0070544)2.82706971
52replicative senescence (GO:0090399)2.81037973
53macroautophagy (GO:0016236)2.80585542
54lipid translocation (GO:0034204)2.80270960
55phospholipid translocation (GO:0045332)2.80270960
56Golgi to endosome transport (GO:0006895)2.76642629
57hypotonic response (GO:0006971)2.74538181
58DNA unwinding involved in DNA replication (GO:0006268)2.72071137
59regulation of protein polyubiquitination (GO:1902914)2.69576278
60growth hormone receptor signaling pathway (GO:0060396)2.67778968
61hemidesmosome assembly (GO:0031581)2.67762572
62regulation of establishment or maintenance of cell polarity (GO:0032878)2.67468829
63dosage compensation (GO:0007549)2.67208331
64bundle of His cell to Purkinje myocyte communication (GO:0086069)2.66877838
65UDP-N-acetylglucosamine metabolic process (GO:0006047)2.66749292
66trophectodermal cell differentiation (GO:0001829)2.65361192
67regulation of sister chromatid cohesion (GO:0007063)2.63903256
68protein demethylation (GO:0006482)2.63857249
69protein dealkylation (GO:0008214)2.63857249
70positive regulation of catenin import into nucleus (GO:0035413)2.62848264
71insulin-like growth factor receptor signaling pathway (GO:0048009)2.62135937
72corticosteroid receptor signaling pathway (GO:0031958)2.60879781
73peptidyl-threonine phosphorylation (GO:0018107)2.60786141
74labyrinthine layer development (GO:0060711)2.60246585
75glucocorticoid receptor signaling pathway (GO:0042921)2.60241690
76diol metabolic process (GO:0034311)2.60199379
77DNA synthesis involved in DNA repair (GO:0000731)2.60143216
78positive regulation of glycolytic process (GO:0045821)2.59283595
79positive regulation of p38MAPK cascade (GO:1900745)2.56798386
80nucleus organization (GO:0006997)2.56083605
81nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.55878214
82stress granule assembly (GO:0034063)2.55574593
83desmosome organization (GO:0002934)2.55384957
84regulation of histone methylation (GO:0031060)2.55130268
85positive regulation of DNA-templated transcription, initiation (GO:2000144)2.55053171
86positive regulation of fatty acid beta-oxidation (GO:0032000)2.54488858
87protein export from nucleus (GO:0006611)2.52174673
88negative regulation of myotube differentiation (GO:0010832)2.52062162
89columnar/cuboidal epithelial cell development (GO:0002066)2.51355485
90regulation of centrosome cycle (GO:0046605)2.49398889
91folic acid-containing compound biosynthetic process (GO:0009396)2.48699977
92phospholipid homeostasis (GO:0055091)2.47397835
93phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.45798165
94positive regulation of hormone biosynthetic process (GO:0046886)2.44977129
95DNA conformation change (GO:0071103)2.44076863
96histone methylation (GO:0016571)2.43974854
97sphingoid metabolic process (GO:0046519)2.42890210
98striated muscle atrophy (GO:0014891)2.42667237
99mitotic nuclear envelope disassembly (GO:0007077)2.42378501
100receptor catabolic process (GO:0032801)2.42193170
101histone H3-K9 demethylation (GO:0033169)2.41955232
102regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.40147097
103sister chromatid cohesion (GO:0007062)2.39585235
104positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.39439704
105regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.39439704
106nucleus localization (GO:0051647)2.38161637
107regulation of cholesterol homeostasis (GO:2000188)2.37648931
108negative regulation of histone modification (GO:0031057)2.37120021
109positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.36908667
110embryonic camera-type eye morphogenesis (GO:0048596)2.35875005
111chemosensory behavior (GO:0007635)2.35865553
112drug transmembrane transport (GO:0006855)2.34852040
113exocrine pancreas development (GO:0031017)2.34508990
114phosphatidylinositol phosphorylation (GO:0046854)2.34412865
115membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.34219080
116non-recombinational repair (GO:0000726)2.34201515
117early endosome to late endosome transport (GO:0045022)2.34189504
118cellular response to growth hormone stimulus (GO:0071378)2.28145326
119photoreceptor cell maintenance (GO:0045494)2.27792751
120hormone catabolic process (GO:0042447)2.27311370
121type B pancreatic cell development (GO:0003323)2.26086068
122endocrine pancreas development (GO:0031018)2.25939584
123positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.24940552
124regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.24940552
125regulation of secondary heart field cardioblast proliferation (GO:0003266)2.24691881
126regulation of cardioblast proliferation (GO:0003264)2.24691881
127negative regulation of hormone biosynthetic process (GO:0032353)2.23361051
128negative regulation of hormone metabolic process (GO:0032351)2.23361051
129histone H3-K4 trimethylation (GO:0080182)2.22319444
130negative regulation of translation, ncRNA-mediated (GO:0040033)2.21856661
131regulation of translation, ncRNA-mediated (GO:0045974)2.21856661
132negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.21856661
133regulation of p38MAPK cascade (GO:1900744)2.19752843
134dorsal/ventral axis specification (GO:0009950)2.18892074
135membrane repolarization during action potential (GO:0086011)2.18434615
136COPII vesicle coating (GO:0048208)2.17861301
137histone lysine demethylation (GO:0070076)2.16337895
138inner ear receptor cell development (GO:0060119)2.16285416
139coronary vasculature morphogenesis (GO:0060977)2.15385455
140regulation of mRNA catabolic process (GO:0061013)2.14938609
141protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.14537402
142lactate metabolic process (GO:0006089)2.10631976
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.10629491
144urea metabolic process (GO:0019627)2.08602407
145urea cycle (GO:0000050)2.08602407
146negative regulation of digestive system process (GO:0060457)2.08545180
147male sex determination (GO:0030238)2.08225923
148pharyngeal system development (GO:0060037)2.08101322
149angiotensin maturation (GO:0002003)2.07033587
150regulation of fatty acid beta-oxidation (GO:0031998)2.06440211
151positive regulation of fatty acid oxidation (GO:0046321)2.06120266
152phospholipid dephosphorylation (GO:0046839)2.06014687
153cytoskeletal anchoring at plasma membrane (GO:0007016)2.04101392
154photoreceptor cell differentiation (GO:0046530)2.02943860
155eye photoreceptor cell differentiation (GO:0001754)2.02943860
156transcytosis (GO:0045056)2.02222239
157phosphatidylinositol dephosphorylation (GO:0046856)2.00274562
158positive regulation of glycogen biosynthetic process (GO:0045725)1.99598595
159homocysteine metabolic process (GO:0050667)1.99509332
160endoplasmic reticulum organization (GO:0007029)1.99099712
161peptide hormone processing (GO:0016486)1.98385145
162regulation of Golgi to plasma membrane protein transport (GO:0042996)1.98318010
163negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)1.96630465
164glandular epithelial cell development (GO:0002068)1.96023528
165carnitine shuttle (GO:0006853)1.95961035
166histone H3-K4 methylation (GO:0051568)1.94919442
167regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.93986062
168regulation of histone deacetylation (GO:0031063)1.93903137
169regulation of hormone biosynthetic process (GO:0046885)1.92688125
170negative regulation of lipase activity (GO:0060192)1.92575072
171histone demethylation (GO:0016577)1.90957734
172peptidyl-threonine modification (GO:0018210)1.90914213
173cell communication involved in cardiac conduction (GO:0086065)1.90611320
174dicarboxylic acid biosynthetic process (GO:0043650)1.90510398
175oocyte development (GO:0048599)1.89710783
176glandular epithelial cell differentiation (GO:0002067)1.89518819
177regulation of steroid hormone biosynthetic process (GO:0090030)1.89396026
178interkinetic nuclear migration (GO:0022027)1.88888265

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.94034658
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.89768043
3KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.58508225
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.54625836
5SCL_19346495_ChIP-Seq_HPC-7_Human2.52741704
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.52219112
7* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.27682684
8GATA1_22025678_ChIP-Seq_K562_Human2.24836634
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92292276
10TP63_17297297_ChIP-ChIP_HaCaT_Human1.87918570
11E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87313475
12AR_21909140_ChIP-Seq_LNCAP_Human1.81695585
13LXR_22158963_ChIP-Seq_LIVER_Mouse1.78170234
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75359131
15AHR_22903824_ChIP-Seq_MCF-7_Human1.73406955
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.72096767
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71854454
18* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63720369
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63646001
20* FOXA2_19822575_ChIP-Seq_HepG2_Human1.58596655
21GBX2_23144817_ChIP-Seq_PC3_Human1.58507522
22PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57424969
23ARNT_22903824_ChIP-Seq_MCF-7_Human1.55138275
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.55136116
25TP53_16413492_ChIP-PET_HCT116_Human1.54984726
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.54740797
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.54448940
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53321230
29* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53201646
30BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.52164594
31* E2F1_21310950_ChIP-Seq_MCF-7_Human1.52081244
32CHD1_26751641_Chip-Seq_LNCaP_Human1.51547638
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.50921059
34MYC_22102868_ChIP-Seq_BL_Human1.50410501
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50214248
36GATA2_19941826_ChIP-Seq_K562_Human1.49584196
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49355870
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.48548740
39* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47890752
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47579925
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45972211
42DROSHA_22980978_ChIP-Seq_HELA_Human1.44131997
43SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40022743
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.38986054
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.35270967
46GATA1_19941826_ChIP-Seq_K562_Human1.34851188
47SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34160714
48CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33460676
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.33179252
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31534236
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31534236
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.31407832
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30398674
54* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27794535
55* STAT3_23295773_ChIP-Seq_U87_Human1.26204752
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25221058
57FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.24516986
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23947674
59* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23857278
60* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23841459
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23043210
62BCAT_22108803_ChIP-Seq_LS180_Human1.22583935
63* SMAD4_21799915_ChIP-Seq_A2780_Human1.22540608
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20669588
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20096571
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19865734
67FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.19705906
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19643833
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17595486
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.17537310
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.16029681
72* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15523052
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15121819
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14864674
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14864674
76PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14074705
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.12439729
78SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12278649
79PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11932109
80MYB_26560356_Chip-Seq_TH1_Human1.11535519
81PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11414838
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09017159
83GATA6_25053715_ChIP-Seq_YYC3_Human1.08637304
84SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06215192
85* TCF4_23295773_ChIP-Seq_U87_Human1.05810046
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05540519
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05110448
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04745039
89* GATA3_24758297_ChIP-Seq_MCF-7_Human1.03965914
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03852957
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03667645
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03382018
93RXR_22108803_ChIP-Seq_LS180_Human1.02828635
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02812875
95* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02809905
96TCF7_22412390_ChIP-Seq_EML_Mouse1.01697609
97MYB_26560356_Chip-Seq_TH2_Human1.01174690
98CDX2_22108803_ChIP-Seq_LS180_Human1.00198315
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99842898
100* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99830364
101RUNX_20019798_ChIP-Seq_JUKART_Human0.99119281
102* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98809740
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98642671
104* GATA2_21666600_ChIP-Seq_HMVEC_Human0.98539365
105* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97957189
106* SMAD3_21741376_ChIP-Seq_HESCs_Human0.96663665
107SMAD3_21741376_ChIP-Seq_EPCs_Human0.96590903
108RUNX1_27514584_Chip-Seq_MCF-7_Human0.96471652
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95538739
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95181028
111TBX20_22080862_ChIP-Seq_HEART_Mouse0.94981098
112TBX20_22328084_ChIP-Seq_HEART_Mouse0.94981098
113CLOCK_20551151_ChIP-Seq_293T_Human0.94697422
114* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94665292
115* GATA1_19941827_ChIP-Seq_MEL_Mouse0.94564416
116FUS_26573619_Chip-Seq_HEK293_Human0.94125765
117* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94047978
118FOXA1_25552417_ChIP-Seq_VCAP_Human0.93778293
119* GATA4_25053715_ChIP-Seq_YYC3_Human0.93699548
120TP63_23658742_ChIP-Seq_EP156T_Human0.93677526
121* AR_19668381_ChIP-Seq_PC3_Human0.93586465
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93395676
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93025266
124IRF8_22096565_ChIP-ChIP_GC-B_Human0.92646907
125PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92364951
126TRIM28_21343339_ChIP-Seq_HEK293_Human0.92337689
127YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92044120
128STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90116013
129* NANOG_18555785_Chip-Seq_ESCs_Mouse0.89566052
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89550087
131AR_21572438_ChIP-Seq_LNCaP_Human0.89071238
132PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88794362
133NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88555955
134* SMAD4_21741376_ChIP-Seq_HESCs_Human0.88494694
135HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88142204
136OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85990641
137* HNF4A_19822575_ChIP-Seq_HepG2_Human0.85922471
138SPI1_23127762_ChIP-Seq_K562_Human0.85863100
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85858552
140VDR_24787735_ChIP-Seq_THP-1_Human0.85823999
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85480622
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84453482

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.19753892
2MP0010234_abnormal_vibrissa_follicle4.80094267
3MP0003300_gastrointestinal_ulcer3.56958081
4MP0003252_abnormal_bile_duct3.44639136
5MP0009780_abnormal_chondrocyte_physiolo3.12995225
6MP0005360_urolithiasis3.08849657
7MP0002009_preneoplasia2.90656833
8MP0004264_abnormal_extraembryonic_tissu2.80583068
9MP0005365_abnormal_bile_salt2.69868013
10MP0003045_fibrosis2.67135685
11MP0000569_abnormal_digit_pigmentation2.50799664
12MP0001666_abnormal_nutrient_absorption2.46075119
13MP0002254_reproductive_system_inflammat2.35687474
14MP0002139_abnormal_hepatobiliary_system2.33985887
15MP0004043_abnormal_pH_regulation2.27544689
16MP0002877_abnormal_melanocyte_morpholog2.22862295
17MP0005085_abnormal_gallbladder_physiolo2.22366083
18MP0010678_abnormal_skin_adnexa2.17199057
19MP0003183_abnormal_peptide_metabolism2.10115522
20MP0005551_abnormal_eye_electrophysiolog2.10109985
21MP0006072_abnormal_retinal_apoptosis1.98816268
22MP0002166_altered_tumor_susceptibility1.97024717
23MP0002396_abnormal_hematopoietic_system1.95604913
24MP0004185_abnormal_adipocyte_glucose1.95139174
25MP0003763_abnormal_thymus_physiology1.89168361
26MP0010094_abnormal_chromosome_stability1.85782608
27MP0004957_abnormal_blastocyst_morpholog1.81197188
28MP0004808_abnormal_hematopoietic_stem1.79923028
29MP0002928_abnormal_bile_duct1.75724105
30MP0002138_abnormal_hepatobiliary_system1.67876328
31MP0005666_abnormal_adipose_tissue1.67679875
32MP0010352_gastrointestinal_tract_polyps1.64945972
33MP0002909_abnormal_adrenal_gland1.61976764
34MP0008961_abnormal_basal_metabolism1.61845006
35MP0003705_abnormal_hypodermis_morpholog1.61362285
36MP0005451_abnormal_body_composition1.59778474
37MP0001346_abnormal_lacrimal_gland1.55807577
38MP0003984_embryonic_growth_retardation1.55278080
39MP0003283_abnormal_digestive_organ1.54386478
40MP0002086_abnormal_extraembryonic_tissu1.53502756
41MP0005253_abnormal_eye_physiology1.53318929
42MP0000383_abnormal_hair_follicle1.50461906
43MP0002088_abnormal_embryonic_growth/wei1.50178251
44MP0000427_abnormal_hair_cycle1.48673219
45MP0003077_abnormal_cell_cycle1.48461006
46MP0000462_abnormal_digestive_system1.45921689
47MP0001765_abnormal_ion_homeostasis1.45168126
48MP0009697_abnormal_copulation1.44868015
49MP0003656_abnormal_erythrocyte_physiolo1.44375740
50MP0005380_embryogenesis_phenotype1.43224712
51MP0001672_abnormal_embryogenesis/_devel1.43224712
52MP0003111_abnormal_nucleus_morphology1.42893928
53MP0002693_abnormal_pancreas_physiology1.42594563
54MP0005310_abnormal_salivary_gland1.42028736
55MP0010329_abnormal_lipoprotein_level1.41366657
56MP0005464_abnormal_platelet_physiology1.40339312
57MP0001944_abnormal_pancreas_morphology1.39863798
58MP0003868_abnormal_feces_composition1.39657426
59MP0003866_abnormal_defecation1.39074325
60MP0004019_abnormal_vitamin_homeostasis1.38346284
61MP0001730_embryonic_growth_arrest1.37086297
62MP0005409_darkened_coat_color1.34731948
63MP0003787_abnormal_imprinting1.34389027
64MP0002006_tumorigenesis1.33510792
65MP0005076_abnormal_cell_differentiation1.33389614
66MP0008875_abnormal_xenobiotic_pharmacok1.30138980
67MP0005670_abnormal_white_adipose1.27888647
68MP0005375_adipose_tissue_phenotype1.22274767
69MP0002084_abnormal_developmental_patter1.21586544
70MP0004381_abnormal_hair_follicle1.21270337
71MP0003195_calcinosis1.21069071
72MP0001299_abnormal_eye_distance/1.19736424
73MP0001661_extended_life_span1.18689645
74MP0004233_abnormal_muscle_weight1.18404453
75MP0002098_abnormal_vibrissa_morphology1.17639631
76MP0005377_hearing/vestibular/ear_phenot1.17387546
77MP0003878_abnormal_ear_physiology1.17387546
78MP0009703_decreased_birth_body1.16060106
79MP0000350_abnormal_cell_proliferation1.15597047
80MP0003943_abnormal_hepatobiliary_system1.15373356
81MP0005248_abnormal_Harderian_gland1.13523385
82MP0002078_abnormal_glucose_homeostasis1.12243810
83MP0001324_abnormal_eye_pigmentation1.11979697
84MP0002896_abnormal_bone_mineralization1.11022042
85MP0004130_abnormal_muscle_cell1.10707442
86MP0001697_abnormal_embryo_size1.09769967
87MP0003091_abnormal_cell_migration1.06667133
88MP0000538_abnormal_urinary_bladder1.06517145
89MP0002090_abnormal_vision1.06344190
90MP0005220_abnormal_exocrine_pancreas1.06158858
91MP0002168_other_aberrant_phenotype1.06146789
92MP0000003_abnormal_adipose_tissue1.06009480
93MP0004084_abnormal_cardiac_muscle1.04853178
94MP0005187_abnormal_penis_morphology1.04148447
95MP0009643_abnormal_urine_homeostasis1.03376627
96MP0005621_abnormal_cell_physiology1.02654060
97MP0005501_abnormal_skin_physiology1.01666777
98MP0003693_abnormal_embryo_hatching0.99750161
99MP0001873_stomach_inflammation0.98812428
100MP0003890_abnormal_embryonic-extraembry0.98589400
101MP0001270_distended_abdomen0.97874042
102MP0002080_prenatal_lethality0.97124135
103MP0002796_impaired_skin_barrier0.95001135
104MP0000678_abnormal_parathyroid_gland0.94827409
105MP0000579_abnormal_nail_morphology0.94702105
106MP0001485_abnormal_pinna_reflex0.93687320
107MP0003011_delayed_dark_adaptation0.93450470
108MP0000627_abnormal_mammary_gland0.92760263
109MP0000703_abnormal_thymus_morphology0.92407046
110MP0000537_abnormal_urethra_morphology0.92396400
111MP0004197_abnormal_fetal_growth/weight/0.92109559
112MP0000609_abnormal_liver_physiology0.91471893
113MP0008004_abnormal_stomach_pH0.90195673
114MP0002118_abnormal_lipid_homeostasis0.88454285
115MP0009672_abnormal_birth_weight0.87728593
116MP0002971_abnormal_brown_adipose0.86656581
117MP0000377_abnormal_hair_follicle0.86280302
118MP0000566_synostosis0.86198573
119MP0005395_other_phenotype0.85401627
120MP0005195_abnormal_posterior_eye0.85042401
121MP0000613_abnormal_salivary_gland0.83797610
122MP0001984_abnormal_olfaction0.83458350
123MP0003453_abnormal_keratinocyte_physiol0.83132348
124MP0010307_abnormal_tumor_latency0.83014553
125MP0002019_abnormal_tumor_incidence0.82988550
126MP0002085_abnormal_embryonic_tissue0.82274394
127MP0005647_abnormal_sex_gland0.81633889
128MP0009384_cardiac_valve_regurgitation0.81577025
129MP0009115_abnormal_fat_cell0.80744440
130MP0001851_eye_inflammation0.79659756
131MP0001756_abnormal_urination0.79605395
132MP0004036_abnormal_muscle_relaxation0.79572798
133MP0002398_abnormal_bone_marrow0.79073580
134MP0005275_abnormal_skin_tensile0.78905733
135MP0001915_intracranial_hemorrhage0.78506861
136MP0010155_abnormal_intestine_physiology0.76388289
137MP0001216_abnormal_epidermal_layer0.76090736
138MP0005334_abnormal_fat_pad0.76058962
139MP0002925_abnormal_cardiovascular_devel0.75565129
140MP0010630_abnormal_cardiac_muscle0.75283385
141MP0005408_hypopigmentation0.74263305
142MP0005391_vision/eye_phenotype0.74092280
143MP0004147_increased_porphyrin_level0.73562902
144MP0003941_abnormal_skin_development0.72878638
145MP0005384_cellular_phenotype0.72817463
146MP0000432_abnormal_head_morphology0.70251809
147MP0001784_abnormal_fluid_regulation0.69778795
148MP0000465_gastrointestinal_hemorrhage0.69514181
149MP0005645_abnormal_hypothalamus_physiol0.68367447
150MP0000477_abnormal_intestine_morphology0.68000347
151MP0000428_abnormal_craniofacial_morphol0.67896030
152MP0001191_abnormal_skin_condition0.67527134
153MP0003950_abnormal_plasma_membrane0.66797465
154MP0002060_abnormal_skin_morphology0.66392451
155MP0003566_abnormal_cell_adhesion0.65700732
156MP0002234_abnormal_pharynx_morphology0.65258450
157MP0002136_abnormal_kidney_physiology0.64690675
158MP0004947_skin_inflammation0.62722543

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)3.92385163
2Pigmentary retinal degeneration (HP:0001146)3.78633977
3Congenital stationary night blindness (HP:0007642)3.65594226
4Central scotoma (HP:0000603)3.36511341
5Bony spicule pigmentary retinopathy (HP:0007737)3.28593631
6Acute myeloid leukemia (HP:0004808)3.16397896
7Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.15349442
8Macroorchidism (HP:0000053)3.15035844
9Conjugated hyperbilirubinemia (HP:0002908)3.08764752
10Chromsome breakage (HP:0040012)3.03956466
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.03433027
12Neonatal hypoglycemia (HP:0001998)2.99049076
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98710969
14Ankyloglossia (HP:0010296)2.94871959
15Hyperinsulinemic hypoglycemia (HP:0000825)2.94395354
16Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.89582031
17Hypoplastic ischia (HP:0003175)2.89098029
18Insulin-resistant diabetes mellitus (HP:0000831)2.84737769
19Abnormality of chloride homeostasis (HP:0011422)2.82406255
20Flat acetabular roof (HP:0003180)2.81318984
21Sandal gap (HP:0001852)2.79695001
22Right ventricular cardiomyopathy (HP:0011663)2.72537578
23Chorioretinal atrophy (HP:0000533)2.71073424
24Hypoglycemic seizures (HP:0002173)2.68595821
25Abnormality of the ischium (HP:0003174)2.65110107
26Hyperkalemia (HP:0002153)2.61597160
27Overlapping toe (HP:0001845)2.60120253
28Hyperactive renin-angiotensin system (HP:0000841)2.58399625
29Hypoglycemic coma (HP:0001325)2.57595558
30Chronic bronchitis (HP:0004469)2.56308439
31Hyperglycemia (HP:0003074)2.50427792
32Ketoacidosis (HP:0001993)2.46278435
33Dyschromatopsia (HP:0007641)2.44373203
34Heterotopia (HP:0002282)2.44081373
35Anal stenosis (HP:0002025)2.43334747
36Hematochezia (HP:0002573)2.43332385
37Sparse lateral eyebrow (HP:0005338)2.40895056
38Symptomatic seizures (HP:0011145)2.38874295
39Deep philtrum (HP:0002002)2.38080447
40Abnormality of macular pigmentation (HP:0008002)2.36092615
41Poikilocytosis (HP:0004447)2.33263430
42Increased mean platelet volume (HP:0011877)2.32877352
43Acute lymphatic leukemia (HP:0006721)2.32414003
44Prominent nose (HP:0000448)2.32073104
45Urethral obstruction (HP:0000796)2.31683342
46Long eyelashes (HP:0000527)2.30357395
47Abnormality of oral frenula (HP:0000190)2.29948127
48Metabolic alkalosis (HP:0200114)2.29244780
49Germ cell neoplasia (HP:0100728)2.29142822
50Abnormality of the distal phalanx of the thumb (HP:0009617)2.25901151
51Intrahepatic cholestasis (HP:0001406)2.25527758
52Abnormality of potassium homeostasis (HP:0011042)2.22287522
53Subacute progressive viral hepatitis (HP:0006572)2.19817825
54Facial shape deformation (HP:0011334)2.19476107
55Potter facies (HP:0002009)2.19476107
56Curly hair (HP:0002212)2.19408195
57Aortic aneurysm (HP:0004942)2.19294590
58Truncal obesity (HP:0001956)2.18406644
59Scotoma (HP:0000575)2.17288066
60Retinal atrophy (HP:0001105)2.15054718
61Volvulus (HP:0002580)2.14438709
62Subcapsular cataract (HP:0000523)2.14289626
63Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.14079959
64Abnormality of the nasal septum (HP:0000419)2.13682854
65Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12275674
66Rectal prolapse (HP:0002035)2.09549664
67Malignant gastrointestinal tract tumors (HP:0006749)2.08674622
68Gastrointestinal carcinoma (HP:0002672)2.08674622
69Cone-rod dystrophy (HP:0000548)2.08577350
70Type II diabetes mellitus (HP:0005978)2.08319082
71Hypoplastic labia majora (HP:0000059)2.07806737
72Bronchitis (HP:0012387)2.07781157
73Abdominal distention (HP:0003270)2.04010987
74T lymphocytopenia (HP:0005403)2.02934414
75Papillary thyroid carcinoma (HP:0002895)2.02585886
76Abnormality of glutamine family amino acid metabolism (HP:0010902)2.02164731
77Advanced eruption of teeth (HP:0006288)2.01199416
78Congenital sensorineural hearing impairment (HP:0008527)2.01028035
79Abnormality of renin-angiotensin system (HP:0000847)2.00839004
80Decreased circulating renin level (HP:0003351)1.99941455
81Hyporeflexia of lower limbs (HP:0002600)1.99813351
82Abnormal platelet volume (HP:0011876)1.99770407
83Hypokalemia (HP:0002900)1.99765640
84* Abnormality of the fingertips (HP:0001211)1.98672557
85* Chronic diarrhea (HP:0002028)1.96812116
86Increased circulating renin level (HP:0000848)1.95970977
87Nephroblastoma (Wilms tumor) (HP:0002667)1.95523812
88Thyroid carcinoma (HP:0002890)1.95335200
89Elfin facies (HP:0004428)1.95176059
90Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.95078821
91Abnormality of the epiphyses of the hand (HP:0005924)1.94502867
92Oligodactyly (hands) (HP:0001180)1.92122505
93Acanthocytosis (HP:0001927)1.91595240
94Viral hepatitis (HP:0006562)1.91491189
95Missing ribs (HP:0000921)1.91453704
96Esophageal varix (HP:0002040)1.90994048
97Low anterior hairline (HP:0000294)1.90509971
98Genetic anticipation (HP:0003743)1.89708905
99Milia (HP:0001056)1.89423486
100Aneurysm (HP:0002617)1.88740557
101Abnormal biliary tract morphology (HP:0012440)1.88505019
102Persistence of primary teeth (HP:0006335)1.88334543
103Obsessive-compulsive behavior (HP:0000722)1.87853554
104Prolonged bleeding time (HP:0003010)1.87538124
105Aqueductal stenosis (HP:0002410)1.87168753
106Hypoalphalipoproteinemia (HP:0003233)1.86856551
107Cerebral aneurysm (HP:0004944)1.85468528
108Rhinitis (HP:0012384)1.84991414
109Menorrhagia (HP:0000132)1.84917787
110Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.84190497
111Rhabdomyosarcoma (HP:0002859)1.83538466
112Abnormal foot bone ossification (HP:0010675)1.82572731
113Abnormality of the labia majora (HP:0012881)1.81822363
114Abnormal pancreas size (HP:0012094)1.80269425
115Biliary tract neoplasm (HP:0100574)1.79867984
116Neoplasm of the small intestine (HP:0100833)1.79278301
117Pancreatic islet-cell hyperplasia (HP:0004510)1.79065134
118Abnormality of nail color (HP:0100643)1.79041410
119Macular degeneration (HP:0000608)1.78414595
120Embryonal renal neoplasm (HP:0011794)1.77526989
121Epidermoid cyst (HP:0200040)1.76867806
122Progressive sensorineural hearing impairment (HP:0000408)1.76227319
123Septate vagina (HP:0001153)1.75336427
124Gingival bleeding (HP:0000225)1.74890794
125Recurrent bronchitis (HP:0002837)1.74418651
126Osteolytic defects of the phalanges of the hand (HP:0009771)1.74122898
127Osteolytic defects of the hand bones (HP:0009699)1.74122898
128Medulloblastoma (HP:0002885)1.73425239
129Dysmetric saccades (HP:0000641)1.73377372
130Focal segmental glomerulosclerosis (HP:0000097)1.73228594
131Abnormality of chromosome stability (HP:0003220)1.73008402
132Abnormality of the right ventricle (HP:0001707)1.70544856
133Relative macrocephaly (HP:0004482)1.70354593
134Micronodular cirrhosis (HP:0001413)1.69751185
135* Abnormality of the gastric mucosa (HP:0004295)1.68415617
136Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68258007
137Hypoplasia of dental enamel (HP:0006297)1.67746429
138Overgrowth (HP:0001548)1.67161861
139Narrow palate (HP:0000189)1.66452595
140Tubulointerstitial nephritis (HP:0001970)1.66025769
141Abnormality of T cell number (HP:0011839)1.65827317
142Portal hypertension (HP:0001409)1.65571635
143Exotropia (HP:0000577)1.65378541
144Hypokalemic alkalosis (HP:0001949)1.65048620
145Labial hypoplasia (HP:0000066)1.64765247
146Abnormality of calcium-phosphate metabolism (HP:0100530)1.64650467
147Cubitus valgus (HP:0002967)1.64550055
148Transitional cell carcinoma of the bladder (HP:0006740)1.63565840
149Abnormality of the renal cortex (HP:0011035)1.63379095
150Enlarged kidneys (HP:0000105)1.63299485
151Abnormality of purine metabolism (HP:0004352)1.63042045
152Ketosis (HP:0001946)1.62263611
153Abnormality of proline metabolism (HP:0010907)1.61944565
154Hydroxyprolinuria (HP:0003080)1.61944565
155Vertebral arch anomaly (HP:0008438)1.61911683
156Widely patent fontanelles and sutures (HP:0004492)1.61392121
157Uterine leiomyosarcoma (HP:0002891)1.61187596
158Leiomyosarcoma (HP:0100243)1.61187596
159Renovascular hypertension (HP:0100817)1.60930270
160Coarse hair (HP:0002208)1.60637340
161Aplasia cutis congenita (HP:0001057)1.59285450
162Progressive hearing impairment (HP:0001730)1.56757200
163Bifid scrotum (HP:0000048)1.56419705
164Chronic hepatic failure (HP:0100626)1.55337009
16511 pairs of ribs (HP:0000878)1.54732629
166Nephritis (HP:0000123)1.54566075
167Periodontitis (HP:0000704)1.54271882
168Abolished electroretinogram (ERG) (HP:0000550)1.53760658
169Arterial tortuosity (HP:0005116)1.53022950
170Abnormality of the hepatic vasculature (HP:0006707)1.51874200
171Pili torti (HP:0003777)1.51684142
172Hepatitis (HP:0012115)1.51573521
173Spontaneous hematomas (HP:0007420)1.51454644

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.51357514
2INSRR3.81460432
3LATS13.10934136
4CAMK1D2.64924259
5CAMK1G2.32493810
6TAOK32.27566575
7NUAK12.25657079
8CDK122.17582671
9STK38L2.17511329
10SIK12.00547667
11FGFR21.77909538
12LMTK21.76418595
13MAP3K21.76127487
14PTK61.75180264
15FGFR31.74324720
16RPS6KB21.69122274
17SGK31.62880619
18RIPK11.57547286
19BRD41.54006194
20HIPK21.47903241
21SGK21.45510709
22CDK91.35179564
23PRKAA21.34074302
24MAPK151.32784268
25GRK11.32324139
26FGFR41.27376927
27EEF2K1.24636632
28ACVR1B1.24505505
29JAK11.24299647
30EPHA31.23403925
31TEC1.21978029
32SMG11.20341476
33BRSK21.18403162
34WNK11.18201325
35PBK1.17905687
36MAP3K71.16814252
37FER1.15260919
38TRIB31.14993708
39MST1R1.14515250
40CDK61.10764247
41WNK31.10713820
42EIF2AK31.09094369
43TGFBR21.09065765
44PRKAA11.09038803
45STK391.08854672
46AKT31.06551773
47DMPK1.06471927
48WNK41.04701455
49PDGFRA1.03880691
50NEK91.02105935
51BMX1.00001326
52BTK0.95090100
53MAP3K100.93769719
54STK30.92049328
55SGK2230.92040462
56SGK4940.92040462
57CDC42BPA0.91116612
58STK240.89982855
59LATS20.88193627
60EIF2AK10.87094272
61PDGFRB0.86785205
62TTK0.86560464
63MELK0.85803325
64TTN0.85747256
65MTOR0.85562970
66EPHA20.84619710
67NEK60.83434350
68STK40.83359949
69EPHB10.81466756
70ZAK0.80631962
71ITK0.79807756
72MST40.76390555
73MAPK110.75012446
74CDC70.74818125
75DYRK1B0.73990071
76SGK10.72918279
77CDK40.71462080
78PIK3CA0.70413496
79ATR0.70342326
80JAK20.69917600
81ATM0.68406436
82TAF10.68100982
83RIPK40.68078253
84PRKCH0.67643211
85STK380.66792131
86MAP3K130.65938843
87CHEK10.65215052
88PKN20.65103699
89ERBB20.63867161
90NLK0.63310967
91STK110.63222209
92CHUK0.62531245
93JAK30.61085892
94PIM10.61030758
95CDK30.60630223
96CSF1R0.59011599
97MAP3K140.58686714
98OXSR10.57751584
99RET0.56541438
100PAK30.56244374
101BMPR20.55854477
102RPS6KB10.54614325
103PASK0.53887658
104MAP2K20.53028100
105PIK3CG0.52729075
106PTK20.52037567
107MET0.51901857
108GSK3A0.50527428
109PRKD10.49791667
110CHEK20.48888535
111PRKD20.48609186
112PLK40.46440924
113YES10.46060386
114MAP3K30.44707195
115ICK0.44062469
116TYK20.43845240
117PHKG10.43398847
118PHKG20.43398847
119FGFR10.43369920
120KSR20.43228311
121STK100.42710523
122PRKCQ0.40772415
123PDK10.40532381
124CDK70.40317661
125ROCK10.40142179
126TRPM70.39583629
127SCYL20.39559558
128NEK20.38480351
129IGF1R0.38365689
130CDK20.37818260
131DDR20.37456282
132MAPK100.37046283
133CAMK40.36896927
134FES0.36489662
135CSNK1D0.36037698
136MARK20.35904165
137PDPK10.35418782
138PKN10.35413732
139PRPF4B0.35234764
140MKNK20.34917211
141MKNK10.34867661
142MAPK140.33144404
143INSR0.32795786
144AKT20.32356826
145IRAK10.30804995

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.96557826
2Nitrogen metabolism_Homo sapiens_hsa009102.43742722
3Phototransduction_Homo sapiens_hsa047442.41625765
4Sulfur metabolism_Homo sapiens_hsa009202.28378781
5Thyroid cancer_Homo sapiens_hsa052162.16484986
6Non-small cell lung cancer_Homo sapiens_hsa052231.95226155
7Lysine degradation_Homo sapiens_hsa003101.91354781
8ABC transporters_Homo sapiens_hsa020101.90557174
9Carbohydrate digestion and absorption_Homo sapiens_hsa049731.89067518
10Type II diabetes mellitus_Homo sapiens_hsa049301.83772508
11Non-homologous end-joining_Homo sapiens_hsa034501.72689733
12Viral carcinogenesis_Homo sapiens_hsa052031.63200116
13B cell receptor signaling pathway_Homo sapiens_hsa046621.59903697
14Platelet activation_Homo sapiens_hsa046111.58503720
15Acute myeloid leukemia_Homo sapiens_hsa052211.56310640
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53623233
17One carbon pool by folate_Homo sapiens_hsa006701.52318763
18Bile secretion_Homo sapiens_hsa049761.50913013
19Fat digestion and absorption_Homo sapiens_hsa049751.45423022
20Colorectal cancer_Homo sapiens_hsa052101.38487060
21Insulin secretion_Homo sapiens_hsa049111.37989220
22Insulin resistance_Homo sapiens_hsa049311.37924429
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36893997
24Fatty acid biosynthesis_Homo sapiens_hsa000611.30290764
25Starch and sucrose metabolism_Homo sapiens_hsa005001.25770077
26Mineral absorption_Homo sapiens_hsa049781.24575021
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22391533
28ErbB signaling pathway_Homo sapiens_hsa040121.22149373
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20955498
30Renal cell carcinoma_Homo sapiens_hsa052111.18489355
31Cell cycle_Homo sapiens_hsa041101.16566009
32Fatty acid degradation_Homo sapiens_hsa000711.16465971
33Vitamin digestion and absorption_Homo sapiens_hsa049771.15908052
34Dorso-ventral axis formation_Homo sapiens_hsa043201.14896851
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14045667
36Inositol phosphate metabolism_Homo sapiens_hsa005621.13720070
37Adherens junction_Homo sapiens_hsa045201.13094208
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12169051
39Arginine biosynthesis_Homo sapiens_hsa002201.10779084
40Protein digestion and absorption_Homo sapiens_hsa049741.09879726
41Circadian rhythm_Homo sapiens_hsa047101.09716123
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05870196
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05825853
44Pancreatic secretion_Homo sapiens_hsa049721.03557445
45PPAR signaling pathway_Homo sapiens_hsa033201.02971711
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02716844
47Tryptophan metabolism_Homo sapiens_hsa003801.02558915
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01270976
49Renin secretion_Homo sapiens_hsa049240.99657729
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99162916
51T cell receptor signaling pathway_Homo sapiens_hsa046600.98826663
52Glioma_Homo sapiens_hsa052140.98315389
53Sphingolipid metabolism_Homo sapiens_hsa006000.97081173
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96557318
55Caffeine metabolism_Homo sapiens_hsa002320.96381750
56VEGF signaling pathway_Homo sapiens_hsa043700.96308253
57Fatty acid metabolism_Homo sapiens_hsa012120.94379009
58Glucagon signaling pathway_Homo sapiens_hsa049220.93232471
59mTOR signaling pathway_Homo sapiens_hsa041500.93035031
60Thyroid hormone synthesis_Homo sapiens_hsa049180.91257182
61Renin-angiotensin system_Homo sapiens_hsa046140.89802893
62mRNA surveillance pathway_Homo sapiens_hsa030150.89400390
63Hepatitis C_Homo sapiens_hsa051600.88415645
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87658804
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87264897
66Gastric acid secretion_Homo sapiens_hsa049710.85456531
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.85037985
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82578127
69Salivary secretion_Homo sapiens_hsa049700.82225198
70Systemic lupus erythematosus_Homo sapiens_hsa053220.81959669
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78633155
72AMPK signaling pathway_Homo sapiens_hsa041520.78158217
73Glycerolipid metabolism_Homo sapiens_hsa005610.77816682
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.77364916
75Measles_Homo sapiens_hsa051620.76669130
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.76108721
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74697155
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73400585
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71624503
80RNA transport_Homo sapiens_hsa030130.71438742
81Propanoate metabolism_Homo sapiens_hsa006400.70013202
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.68444251
83Selenocompound metabolism_Homo sapiens_hsa004500.68314695
84Tight junction_Homo sapiens_hsa045300.67646215
85Prostate cancer_Homo sapiens_hsa052150.66590185
86TGF-beta signaling pathway_Homo sapiens_hsa043500.66229403
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64952324
88Hepatitis B_Homo sapiens_hsa051610.64857020
89Influenza A_Homo sapiens_hsa051640.63677953
90Insulin signaling pathway_Homo sapiens_hsa049100.63611795
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63518556
92cAMP signaling pathway_Homo sapiens_hsa040240.63124648
93Small cell lung cancer_Homo sapiens_hsa052220.62940754
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61620260
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60695283
96Bladder cancer_Homo sapiens_hsa052190.60237773
97Fanconi anemia pathway_Homo sapiens_hsa034600.59857537
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.59814746
99Olfactory transduction_Homo sapiens_hsa047400.59366757
100Estrogen signaling pathway_Homo sapiens_hsa049150.58277837
101Focal adhesion_Homo sapiens_hsa045100.57909765
102Taste transduction_Homo sapiens_hsa047420.57803808
103Choline metabolism in cancer_Homo sapiens_hsa052310.57477826
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.57303116
105Endometrial cancer_Homo sapiens_hsa052130.57128710
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.56936568
107Prolactin signaling pathway_Homo sapiens_hsa049170.56713742
108FoxO signaling pathway_Homo sapiens_hsa040680.56640940
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56253812
110Dilated cardiomyopathy_Homo sapiens_hsa054140.55705687
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55482058
112Apoptosis_Homo sapiens_hsa042100.55079227
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.55003476
114Pathways in cancer_Homo sapiens_hsa052000.54903074
115ECM-receptor interaction_Homo sapiens_hsa045120.54151476
116Mismatch repair_Homo sapiens_hsa034300.53589984
117HTLV-I infection_Homo sapiens_hsa051660.53490543
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52689932
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52375366
120p53 signaling pathway_Homo sapiens_hsa041150.51884263
121N-Glycan biosynthesis_Homo sapiens_hsa005100.51015823
122Melanoma_Homo sapiens_hsa052180.50989171
123Retinol metabolism_Homo sapiens_hsa008300.50713516
124Chronic myeloid leukemia_Homo sapiens_hsa052200.50290238
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.49555786
126Pancreatic cancer_Homo sapiens_hsa052120.49026678
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48615932
128HIF-1 signaling pathway_Homo sapiens_hsa040660.47003211
129Notch signaling pathway_Homo sapiens_hsa043300.46902989
130Butanoate metabolism_Homo sapiens_hsa006500.46782529
131Proteoglycans in cancer_Homo sapiens_hsa052050.46446066
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46425242
133Cocaine addiction_Homo sapiens_hsa050300.44751113
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.44453048
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44367169
136Cholinergic synapse_Homo sapiens_hsa047250.44223362
137Herpes simplex infection_Homo sapiens_hsa051680.44015225
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44010459
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43810474
140Nucleotide excision repair_Homo sapiens_hsa034200.43594473
141Amoebiasis_Homo sapiens_hsa051460.42830501
142Histidine metabolism_Homo sapiens_hsa003400.42604266
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41409286
144MicroRNAs in cancer_Homo sapiens_hsa052060.41311678
145Complement and coagulation cascades_Homo sapiens_hsa046100.38295115
146GnRH signaling pathway_Homo sapiens_hsa049120.37668612
147Alcoholism_Homo sapiens_hsa050340.37667183
148Toxoplasmosis_Homo sapiens_hsa051450.37340884
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.36510624
150Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35504273

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