LRCH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)5.50429417
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.14845996
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.14845996
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.93772453
5positive regulation of gamma-delta T cell activation (GO:0046645)4.85962281
6NIK/NF-kappaB signaling (GO:0038061)4.11170919
7regulation of interleukin-12 biosynthetic process (GO:0045075)3.84642466
8regulation of vitamin D biosynthetic process (GO:0060556)3.84058232
9regulation of dendritic cell antigen processing and presentation (GO:0002604)3.80556665
10modulation by symbiont of host defense response (GO:0052031)3.76486411
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.76486411
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.76486411
13positive regulation by organism of defense response of other organism involved in symbiotic interact3.76486411
14modulation by symbiont of host immune response (GO:0052553)3.76486411
15positive regulation by symbiont of host defense response (GO:0052509)3.76486411
16CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.71128194
17positive regulation of interferon-alpha production (GO:0032727)3.64432096
18positive regulation of antigen processing and presentation (GO:0002579)3.63368290
19regulation of interferon-beta biosynthetic process (GO:0045357)3.60549091
20JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.60278524
21regulation of gamma-delta T cell activation (GO:0046643)3.60204286
22regulation of gamma-delta T cell differentiation (GO:0045586)3.54708768
23regulation of interferon-alpha production (GO:0032647)3.47311996
24positive thymic T cell selection (GO:0045059)3.45577882
25negative thymic T cell selection (GO:0045060)3.34981754
26interferon-gamma-mediated signaling pathway (GO:0060333)3.33498758
27myeloid dendritic cell differentiation (GO:0043011)3.32085049
28neutrophil activation involved in immune response (GO:0002283)3.32076551
29positive regulation of B cell differentiation (GO:0045579)3.30711976
30immunoglobulin mediated immune response (GO:0016064)3.30402731
31cellular response to zinc ion (GO:0071294)3.27680651
32response to type I interferon (GO:0034340)3.24960149
33response to muramyl dipeptide (GO:0032495)3.24582159
34negative T cell selection (GO:0043383)3.23875606
35type I interferon signaling pathway (GO:0060337)3.18058903
36cellular response to type I interferon (GO:0071357)3.18058903
37regulation of B cell receptor signaling pathway (GO:0050855)3.16519952
38regulation of immunoglobulin secretion (GO:0051023)3.14412726
39myeloid dendritic cell activation (GO:0001773)3.13986536
40positive regulation of isotype switching (GO:0045830)3.13548785
41thymic T cell selection (GO:0045061)3.13221419
42B cell proliferation (GO:0042100)3.13166140
43neutrophil activation (GO:0042119)3.13053428
44negative regulation of interleukin-12 production (GO:0032695)3.12920310
45regulation of B cell differentiation (GO:0045577)3.07946810
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06364448
47regulation of vitamin metabolic process (GO:0030656)3.06155261
48positive regulation of natural killer cell differentiation (GO:0032825)3.06102526
49regulation of antigen processing and presentation (GO:0002577)3.04275967
50granulocyte activation (GO:0036230)3.02274485
51macrophage activation involved in immune response (GO:0002281)3.01184955
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00864450
53B cell homeostasis (GO:0001782)2.98885062
54cellular response to ethanol (GO:0071361)2.96230353
55regulation of cytokine secretion involved in immune response (GO:0002739)2.93787875
56T cell selection (GO:0045058)2.92575110
57germinal center formation (GO:0002467)2.91302593
58positive regulation of interleukin-17 production (GO:0032740)2.91136337
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.88539025
60regulation of T cell tolerance induction (GO:0002664)2.88337381
61positive regulation of interleukin-12 production (GO:0032735)2.87775536
62histone H3-K4 trimethylation (GO:0080182)2.86947801
63positive regulation of immunoglobulin mediated immune response (GO:0002891)2.86720141
64positive regulation of B cell mediated immunity (GO:0002714)2.86720141
65natural killer cell differentiation (GO:0001779)2.85931900
66response to protozoan (GO:0001562)2.85319855
67positive regulation of interferon-beta production (GO:0032728)2.83424302
68T cell lineage commitment (GO:0002360)2.82596152
69positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.82446283
70mature B cell differentiation (GO:0002335)2.82107574
71glomerular visceral epithelial cell development (GO:0072015)2.81821862
72dendritic cell differentiation (GO:0097028)2.79501477
73B cell receptor signaling pathway (GO:0050853)2.78188235
74regulation of podosome assembly (GO:0071801)2.77527748
75negative regulation of cell killing (GO:0031342)2.73703301
76negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.73703301
77regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.72636348
78positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.72604478
79protein localization to endosome (GO:0036010)2.72590278
80antigen processing and presentation via MHC class Ib (GO:0002475)2.70606625
81regulation of T-helper cell differentiation (GO:0045622)2.70306315
82mature B cell differentiation involved in immune response (GO:0002313)2.70273432
83regulation of T-helper 1 cell differentiation (GO:0045625)2.70191696
84growth hormone receptor signaling pathway (GO:0060396)2.68992225
85leukocyte aggregation (GO:0070486)2.67811410
86negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.67045305
87positive T cell selection (GO:0043368)2.66057670
88regulation of type I interferon-mediated signaling pathway (GO:0060338)2.65691629
89tolerance induction (GO:0002507)2.65458341
90response to peptidoglycan (GO:0032494)2.63043954
91hepatocyte apoptotic process (GO:0097284)2.62940819
92establishment of endothelial barrier (GO:0061028)2.62274786
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.62095349
94regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.61767585
95response to host (GO:0075136)2.59660268
96response to host defenses (GO:0052200)2.59660268
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.59660268
98activation of MAPKKK activity (GO:0000185)2.59419245
99positive regulation of interleukin-2 production (GO:0032743)2.58543400
100regulation of interleukin-12 production (GO:0032655)2.55193104
101positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53490941
102positive regulation of T-helper cell differentiation (GO:0045624)2.53460810
103regulation of isotype switching (GO:0045191)2.53022239
104regulation of RIG-I signaling pathway (GO:0039535)2.51675166
105regulation of alpha-beta T cell proliferation (GO:0046640)2.51392523
106leukocyte cell-cell adhesion (GO:0007159)2.50282368
107response to interleukin-15 (GO:0070672)2.49070943
108positive regulation of DNA recombination (GO:0045911)2.48606815
109B cell mediated immunity (GO:0019724)2.48546021
110T-helper 1 type immune response (GO:0042088)2.48155298
111positive regulation of B cell activation (GO:0050871)2.47895442
112positive regulation of type 2 immune response (GO:0002830)2.47778476
113response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.46639827
114response to host immune response (GO:0052572)2.46639827
115regulation of NFAT protein import into nucleus (GO:0051532)2.45291103
116cellular response to thyroid hormone stimulus (GO:0097067)2.45103528
117natural killer cell activation (GO:0030101)2.45021976
118JAK-STAT cascade (GO:0007259)2.43720232
119positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.43201694
120regulation of T-helper 2 cell differentiation (GO:0045628)2.43039255
121positive regulation of humoral immune response (GO:0002922)2.42969630
122T cell migration (GO:0072678)2.42895631
123CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.42844523
124T-helper cell differentiation (GO:0042093)2.42844523
125cellular extravasation (GO:0045123)2.42765234
126regulation of chronic inflammatory response (GO:0002676)2.41559725
127endothelial tube morphogenesis (GO:0061154)2.41122118
128morphogenesis of an endothelium (GO:0003159)2.41122118
129pinocytosis (GO:0006907)2.41120870
130regulation of interleukin-17 production (GO:0032660)2.41106920
131positive regulation of chemokine biosynthetic process (GO:0045080)2.40555687
132detection of other organism (GO:0098543)2.39917810
133lipopolysaccharide-mediated signaling pathway (GO:0031663)2.39492640
134positive regulation of defense response to virus by host (GO:0002230)2.38844937
135cellular response to virus (GO:0098586)2.38429706
136regulation of B cell proliferation (GO:0030888)2.38383918
137response to laminar fluid shear stress (GO:0034616)2.38278740
138myeloid cell activation involved in immune response (GO:0002275)2.37272284
139cellular response to interferon-gamma (GO:0071346)2.36928678
140positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.36891885
141regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.36837802
142negative regulation of bone resorption (GO:0045779)2.36468900
143regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.35969069
144cellular response to exogenous dsRNA (GO:0071360)2.35953624
145interferon-gamma production (GO:0032609)2.35660762
146positive regulation of B cell proliferation (GO:0030890)2.35509683
147glomerular epithelial cell development (GO:0072310)2.35418677
148T cell proliferation (GO:0042098)2.35383006
149regulation of interleukin-2 biosynthetic process (GO:0045076)2.34498241
150regulation of B cell mediated immunity (GO:0002712)2.34259219
151detection of molecule of bacterial origin (GO:0032490)2.34247306
152regulation of germinal center formation (GO:0002634)2.34117162
153defense response to protozoan (GO:0042832)2.33127589
154regulation of interferon-gamma biosynthetic process (GO:0045072)2.31090871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.46583180
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.02611765
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.53571746
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.03494802
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.84163415
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.51277512
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.46029100
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.45318832
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.40783338
10* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.21718780
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.08661997
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.02320637
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88844861
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63770694
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62517321
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.60567952
17RUNX_20019798_ChIP-Seq_JUKART_Human2.59838460
18GATA1_22025678_ChIP-Seq_K562_Human2.48240181
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30891839
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.30358307
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.23944520
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.11544266
23MYC_22102868_ChIP-Seq_BL_Human2.11221089
24MYB_26560356_Chip-Seq_TH2_Human2.05445915
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02344391
26SCL_19346495_ChIP-Seq_HPC-7_Human1.99851248
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97778917
28MAF_26560356_Chip-Seq_TH1_Human1.97771747
29TCF7_22412390_ChIP-Seq_EML_Mouse1.92616754
30MYB_26560356_Chip-Seq_TH1_Human1.79031448
31* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78936960
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.77236101
33SPI1_23127762_ChIP-Seq_K562_Human1.76501056
34VDR_24763502_ChIP-Seq_THP-1_Human1.73966273
35VDR_21846776_ChIP-Seq_THP-1_Human1.71534985
36* SMAD_19615063_ChIP-ChIP_OVARY_Human1.69522994
37* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.66034773
38* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63042288
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61496844
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.57878912
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55076786
42VDR_24787735_ChIP-Seq_THP-1_Human1.53528612
43UTX_26944678_Chip-Seq_JUKART_Human1.53446720
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.48531930
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47711067
46KDM2B_26808549_Chip-Seq_DND41_Human1.45536362
47* GATA3_27048872_Chip-Seq_THYMUS_Human1.42400350
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39063582
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.37045116
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.36105708
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.33961710
52PU_27001747_Chip-Seq_BMDM_Mouse1.33302031
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32449652
54* SPI1_23547873_ChIP-Seq_NB4_Human1.31348825
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30924328
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.28192585
57* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27068647
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25100353
59* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23861712
60BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21403441
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16129148
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16059072
63* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14079364
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14035570
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10159159
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09564695
67GATA1_19941826_ChIP-Seq_K562_Human1.08930345
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08432522
69* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08285435
70TP53_16413492_ChIP-PET_HCT116_Human1.06645208
71* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06119208
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06112511
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.05999170
74CLOCK_20551151_ChIP-Seq_293T_Human1.05880985
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05467113
76* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05138708
77* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05138708
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04990807
79AHR_22903824_ChIP-Seq_MCF-7_Human1.04507240
80* KDM2B_26808549_Chip-Seq_JURKAT_Human1.01789984
81* UBF1/2_26484160_Chip-Seq_HMECs_Human1.00418883
82GATA2_19941826_ChIP-Seq_K562_Human0.99986444
83* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99920026
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99731093
85* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98813079
86CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98168594
87SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95836569
88* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94649443
89GATA3_26560356_Chip-Seq_TH2_Human0.93585840
90PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92976604
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92213669
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91464092
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90744753
94CJUN_26792858_Chip-Seq_BT549_Human0.89979092
95GATA1_19941827_ChIP-Seq_MEL_Mouse0.89870561
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89854775
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89821919
98* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89457776
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89087725
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88324488
101* BRD4_25478319_ChIP-Seq_HGPS_Human0.87034952
102LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86766290
103* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86304728
104* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86132232
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85440831
106SOX2_20726797_ChIP-Seq_SW620_Human0.85389271
107EP300_21415370_ChIP-Seq_HL-1_Mouse0.85369277
108* TBX20_22328084_ChIP-Seq_HEART_Mouse0.85331256
109* TBX20_22080862_ChIP-Seq_HEART_Mouse0.85331256
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84807502
111* FOXA2_19822575_ChIP-Seq_HepG2_Human0.84577266
112MAF_26560356_Chip-Seq_TH2_Human0.83279254
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81788125
114* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81492668
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80622778
116NFIB_24661679_ChIP-Seq_LUNG_Mouse0.80034552
117* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79899348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.99069707
2MP0002254_reproductive_system_inflammat3.56783539
3MP0000685_abnormal_immune_system3.39376848
4MP0001790_abnormal_immune_system3.04032817
5MP0005387_immune_system_phenotype3.04032817
6MP0003303_peritoneal_inflammation2.87534146
7MP0005671_abnormal_response_to2.75891877
8MP0001800_abnormal_humoral_immune2.66342300
9MP0003436_decreased_susceptibility_to2.64031177
10MP0005000_abnormal_immune_tolerance2.56540430
11MP0003300_gastrointestinal_ulcer2.51339353
12MP0004510_myositis2.47023475
13MP0002452_abnormal_antigen_presenting2.40722548
14MP0002148_abnormal_hypersensitivity_rea2.31538563
15MP0002166_altered_tumor_susceptibility2.31380826
16MP0009785_altered_susceptibility_to2.31124789
17MP0002723_abnormal_immune_serum2.24873288
18MP0003724_increased_susceptibility_to2.24684241
19MP0003763_abnormal_thymus_physiology2.20847279
20MP0002138_abnormal_hepatobiliary_system2.17681047
21MP0005025_abnormal_response_to2.13120403
22MP0002419_abnormal_innate_immunity2.09301494
23MP0001819_abnormal_immune_cell2.08998895
24MP0002420_abnormal_adaptive_immunity2.07914099
25MP0002139_abnormal_hepatobiliary_system1.99143763
26MP0008057_abnormal_DNA_replication1.98761582
27MP0002006_tumorigenesis1.95673698
28MP0004947_skin_inflammation1.93845465
29MP0005451_abnormal_body_composition1.93673220
30MP0006082_CNS_inflammation1.89855997
31MP0005310_abnormal_salivary_gland1.80657683
32MP0010155_abnormal_intestine_physiology1.79553670
33MP0002405_respiratory_system_inflammati1.76109230
34MP0002398_abnormal_bone_marrow1.73386532
35MP0001873_stomach_inflammation1.73275204
36MP0000716_abnormal_immune_system1.70333308
37MP0010234_abnormal_vibrissa_follicle1.63810896
38MP0005076_abnormal_cell_differentiation1.56535208
39MP0001853_heart_inflammation1.56397774
40MP0001845_abnormal_inflammatory_respons1.56048887
41MP0001879_abnormal_lymphatic_vessel1.55463986
42MP0006054_spinal_hemorrhage1.55436289
43MP0005464_abnormal_platelet_physiology1.54163179
44MP0003828_pulmonary_edema1.54041587
45MP0002877_abnormal_melanocyte_morpholog1.52701325
46MP0000604_amyloidosis1.51218614
47MP0003950_abnormal_plasma_membrane1.47737372
48MP0010352_gastrointestinal_tract_polyps1.46017435
49MP0001533_abnormal_skeleton_physiology1.45573511
50MP0003183_abnormal_peptide_metabolism1.42525900
51MP0009840_abnormal_foam_cell1.42426294
52MP0003566_abnormal_cell_adhesion1.41738828
53MP0009278_abnormal_bone_marrow1.40041151
54MP0002396_abnormal_hematopoietic_system1.39855700
55MP0003045_fibrosis1.38388059
56MP0002429_abnormal_blood_cell1.33586861
57MP0001346_abnormal_lacrimal_gland1.32158447
58MP0001851_eye_inflammation1.32077829
59MP0002722_abnormal_immune_system1.30626884
60MP0003448_altered_tumor_morphology1.30008017
61MP0003453_abnormal_keratinocyte_physiol1.29795084
62MP0000689_abnormal_spleen_morphology1.26463183
63MP0001348_abnormal_lacrimal_gland1.23617475
64MP0008961_abnormal_basal_metabolism1.21552350
65MP0003091_abnormal_cell_migration1.18980888
66MP0002009_preneoplasia1.18975073
67MP0002933_joint_inflammation1.16626073
68MP0000703_abnormal_thymus_morphology1.14756061
69MP0001545_abnormal_hematopoietic_system1.11886566
70MP0005397_hematopoietic_system_phenotyp1.11886566
71MP0002998_abnormal_bone_remodeling1.11154142
72MP0000569_abnormal_digit_pigmentation1.10924397
73MP0002332_abnormal_exercise_endurance1.10018358
74MP0009333_abnormal_splenocyte_physiolog1.09087693
75MP0008469_abnormal_protein_level1.06796112
76MP0008004_abnormal_stomach_pH1.05681874
77MP0003866_abnormal_defecation1.03855043
78MP0004808_abnormal_hematopoietic_stem1.03057906
79MP0002277_abnormal_respiratory_mucosa1.00064946
80MP0003191_abnormal_cellular_cholesterol0.97715157
81MP0000767_abnormal_smooth_muscle0.97164995
82MP0003075_altered_response_to0.96471979
83MP0003172_abnormal_lysosome_physiology0.95942744
84MP0000858_altered_metastatic_potential0.94645925
85MP0000371_diluted_coat_color0.94210561
86MP0005058_abnormal_lysosome_morphology0.94111981
87MP0009764_decreased_sensitivity_to0.93786949
88MP0008438_abnormal_cutaneous_collagen0.92619615
89MP0009115_abnormal_fat_cell0.92328673
90MP0003279_aneurysm0.89497829
91MP0002928_abnormal_bile_duct0.89209155
92MP0005023_abnormal_wound_healing0.88727055
93MP0005166_decreased_susceptibility_to0.87881843
94MP0002693_abnormal_pancreas_physiology0.87751194
95MP0003656_abnormal_erythrocyte_physiolo0.86254409
96MP0000343_altered_response_to0.85929458
97MP0005167_abnormal_blood-brain_barrier0.85818612
98MP0005257_abnormal_intraocular_pressure0.83254010
99MP0000465_gastrointestinal_hemorrhage0.82584546
100MP0004272_abnormal_basement_membrane0.81509447
101MP0005621_abnormal_cell_physiology0.80274448
102MP0003705_abnormal_hypodermis_morpholog0.79529333
103MP0010307_abnormal_tumor_latency0.79079855
104MP0000249_abnormal_blood_vessel0.78730245
105MP0005164_abnormal_response_to0.78201431
106MP0010368_abnormal_lymphatic_system0.77639600
107MP0004782_abnormal_surfactant_physiolog0.76587606
108MP0000003_abnormal_adipose_tissue0.76392054
109MP0005666_abnormal_adipose_tissue0.76193443
110MP0010678_abnormal_skin_adnexa0.76083782
111MP0002060_abnormal_skin_morphology0.76014359
112MP0005390_skeleton_phenotype0.76011145
113MP0000013_abnormal_adipose_tissue0.74437800
114MP0000015_abnormal_ear_pigmentation0.74253751
115MP0001216_abnormal_epidermal_layer0.72537853
116MP0002136_abnormal_kidney_physiology0.72318474
117MP0000383_abnormal_hair_follicle0.72141370
118MP0005275_abnormal_skin_tensile0.71453762
119MP0003868_abnormal_feces_composition0.69861931
120MP0005375_adipose_tissue_phenotype0.69394401
121MP0003795_abnormal_bone_structure0.66743748
122MP0001191_abnormal_skin_condition0.61994399
123MP0001915_intracranial_hemorrhage0.58553412

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.27295090
2Recurrent fungal infections (HP:0002841)4.22685997
3Recurrent abscess formation (HP:0002722)4.16402603
4Hematochezia (HP:0002573)4.12531297
5Recurrent bacterial skin infections (HP:0005406)4.08072166
6Recurrent viral infections (HP:0004429)3.80996157
7Abnormality of glycolipid metabolism (HP:0010969)3.58568211
8Abnormality of liposaccharide metabolism (HP:0010968)3.58568211
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.58568211
10Myositis (HP:0100614)3.50515298
11Recurrent cutaneous fungal infections (HP:0011370)3.49538156
12Chronic mucocutaneous candidiasis (HP:0002728)3.49538156
13Mediastinal lymphadenopathy (HP:0100721)3.46832321
14Autoimmune thrombocytopenia (HP:0001973)3.46360671
15Chronic otitis media (HP:0000389)3.40514051
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.37484662
17Colitis (HP:0002583)3.34467398
18Increased IgE level (HP:0003212)3.33310383
19Elevated erythrocyte sedimentation rate (HP:0003565)3.30038332
20Agammaglobulinemia (HP:0004432)3.29138789
21Vasculitis (HP:0002633)3.23378005
22Orchitis (HP:0100796)3.21283752
23Cellulitis (HP:0100658)3.16583334
24Spontaneous hematomas (HP:0007420)3.16361752
25Abnormality of the fingertips (HP:0001211)3.14876242
26Recurrent skin infections (HP:0001581)3.05480248
27Recurrent gram-negative bacterial infections (HP:0005420)3.00232566
28Panhypogammaglobulinemia (HP:0003139)2.96107163
29Interstitial pulmonary disease (HP:0006530)2.93250896
30Retrobulbar optic neuritis (HP:0100654)2.91929392
31Optic neuritis (HP:0100653)2.91929392
32Periodontitis (HP:0000704)2.90635750
33Inflammation of the large intestine (HP:0002037)2.89763816
34Pulmonary infiltrates (HP:0002113)2.88723774
35Recurrent bronchitis (HP:0002837)2.88027489
36Abnormality of the nasal mucosa (HP:0000433)2.83673537
37Cerebral aneurysm (HP:0004944)2.79095738
38Gastrointestinal inflammation (HP:0004386)2.74074772
39Abnormality of macrophages (HP:0004311)2.71371933
40Meningitis (HP:0001287)2.67024387
41Gingivitis (HP:0000230)2.66650732
42Abnormality of T cell number (HP:0011839)2.62473294
43Pustule (HP:0200039)2.61009378
44Eosinophilia (HP:0001880)2.56800282
45Emphysema (HP:0002097)2.54978928
46Increased IgM level (HP:0003496)2.54400868
47Nasal polyposis (HP:0100582)2.52481561
48Arterial thrombosis (HP:0004420)2.51990687
49Hemoptysis (HP:0002105)2.45121073
50Gastrointestinal stroma tumor (HP:0100723)2.44583610
51Restrictive lung disease (HP:0002091)2.44088484
52Milia (HP:0001056)2.42998265
53T lymphocytopenia (HP:0005403)2.41484419
54Osteomyelitis (HP:0002754)2.39215051
55Thoracolumbar scoliosis (HP:0002944)2.38714222
56Stomatitis (HP:0010280)2.34993112
57Autoimmune hemolytic anemia (HP:0001890)2.34813932
58Hypergammaglobulinemia (HP:0010702)2.34364934
59Viral hepatitis (HP:0006562)2.33346776
60Keratoconjunctivitis (HP:0001096)2.32821721
61Chronic diarrhea (HP:0002028)2.28648985
62Abnormality of T cells (HP:0002843)2.28361149
63Aortic aneurysm (HP:0004942)2.26388893
64Leukocytosis (HP:0001974)2.26100592
65Spondylolisthesis (HP:0003302)2.22471002
66Esophageal varix (HP:0002040)2.21962495
67Increased cerebral lipofuscin (HP:0011813)2.20811406
68Systemic lupus erythematosus (HP:0002725)2.20382818
69Abnormality of T cell physiology (HP:0011840)2.18287156
70Thyroiditis (HP:0100646)2.18184142
71Chest pain (HP:0100749)2.17122000
72Loss of speech (HP:0002371)2.13695153
73Tetraparesis (HP:0002273)2.12805220
74Gastrointestinal infarctions (HP:0005244)2.11395886
75Skin ulcer (HP:0200042)2.10686638
76IgA deficiency (HP:0002720)2.06364183
77Abnormality of eosinophils (HP:0001879)2.05569937
78IgM deficiency (HP:0002850)2.04121320
79Abnormality of the gastric mucosa (HP:0004295)2.03244005
80Subacute progressive viral hepatitis (HP:0006572)2.01222515
81Abnormality of cells of the lymphoid lineage (HP:0012140)1.98883185
82Granulocytopenia (HP:0001913)1.98273455
83Lymphopenia (HP:0001888)1.97306439
84Papilloma (HP:0012740)1.94556064
85Verrucae (HP:0200043)1.94556064
86Dysostosis multiplex (HP:0000943)1.94022141
87Myocardial infarction (HP:0001658)1.92317239
88Premature loss of primary teeth (HP:0006323)1.92244260
89Mucopolysacchariduria (HP:0008155)1.91355374
90Urinary glycosaminoglycan excretion (HP:0003541)1.91355374
91Sepsis (HP:0100806)1.90789279
92Vacuolated lymphocytes (HP:0001922)1.90601892
93Nephritis (HP:0000123)1.89584330
94Obstructive lung disease (HP:0006536)1.88960568
95Chronic obstructive pulmonary disease (HP:0006510)1.88960568
96B lymphocytopenia (HP:0010976)1.88673875
97Abnormality of B cell number (HP:0010975)1.88673875
98Disinhibition (HP:0000734)1.88377394
99Lip pit (HP:0100267)1.88249253
100Thick nail (HP:0001805)1.88150702
101Basal ganglia calcification (HP:0002135)1.86626082
102Recurrent sinusitis (HP:0011108)1.86144395
103Apathy (HP:0000741)1.85532195
104Vascular tortuosity (HP:0004948)1.84838540
105Polycythemia (HP:0001901)1.84468387
106Recurrent pneumonia (HP:0006532)1.84035490
107Keratoconjunctivitis sicca (HP:0001097)1.83483436
108Recurrent lower respiratory tract infections (HP:0002783)1.83390906
109Persistence of primary teeth (HP:0006335)1.83191852
110Right ventricular cardiomyopathy (HP:0011663)1.82741575
111Arterial tortuosity (HP:0005116)1.82736500
112Fatigue (HP:0012378)1.81873504
113Abnormality of the peritoneum (HP:0002585)1.81846766
114Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81511341
115Chronic sinusitis (HP:0011109)1.80564617
116Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79976376
117Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79976376
118Dysmetric saccades (HP:0000641)1.79429235
119Lymphedema (HP:0001004)1.79388790
120Glomerulonephritis (HP:0000099)1.77766198
121Cutis marmorata (HP:0000965)1.77278656
122Transitional cell carcinoma of the bladder (HP:0006740)1.76995380
123Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76389160
124Diminished motivation (HP:0000745)1.75254862
125Cubitus valgus (HP:0002967)1.71731460
126Increased neuronal autofluorescent lipopigment (HP:0002074)1.71627282
127Hepatitis (HP:0012115)1.69707729
128Bladder carcinoma (HP:0002862)1.69243470
129Bladder neoplasm (HP:0009725)1.69243470
130Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68852241
131Abnormality of the periventricular white matter (HP:0002518)1.67657606
132Segmental peripheral demyelination/remyelination (HP:0003481)1.67597922
133Thin bony cortex (HP:0002753)1.66839219
134Broad face (HP:0000283)1.65910723
135Lymphoma (HP:0002665)1.64687045
136Arthralgia (HP:0002829)1.63799611
137Cupped ribs (HP:0000887)1.63273754
138Anhidrosis (HP:0000970)1.63154680
139Flat acetabular roof (HP:0003180)1.63041307
140Abnormal foot bone ossification (HP:0010675)1.61248892
141Slow saccadic eye movements (HP:0000514)1.61011657
142Acrocyanosis (HP:0001063)1.60990328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.75269673
2MAP4K13.60952720
3MAP3K143.52724066
4TYK23.17541381
5TGFBR22.92316002
6JAK32.81291259
7ERN12.60545108
8TBK12.36773428
9JAK12.29861264
10FGFR42.10935185
11EPHA32.08025873
12IKBKE2.02667807
13DDR21.97867585
14STK101.96369116
15BLK1.95565266
16FGFR31.92120068
17IKBKB1.91698765
18CHUK1.90931678
19MAP3K131.88771576
20MAPK151.82826901
21EPHB11.75085042
22ZAP701.74346269
23IRAK41.67288261
24TXK1.67046641
25KIT1.65362653
26ITK1.63060420
27CSK1.61007276
28ICK1.55788574
29CDC42BPA1.55425620
30PTK61.50857973
31NLK1.47814158
32RIPK41.42949806
33CSF1R1.40862403
34CDK121.37804268
35MAP3K101.32032153
36BTK1.29906938
37KDR1.26481860
38FGR1.22160808
39INSRR1.19993618
40SYK1.19759600
41TEC1.19509417
42HIPK21.19502136
43HCK1.17487246
44JAK21.17223478
45IRAK31.16736656
46TGFBR11.13124780
47TAOK21.12798748
48EIF2AK31.10565907
49EEF2K1.08742942
50CAMK1D1.06049248
51LCK1.02164132
52MAPK110.99378453
53RIPK10.96976418
54FLT30.96168017
55CAMK1G0.93703049
56RPS6KA40.92978907
57MOS0.92621457
58NME20.92570771
59DMPK0.91947971
60MAP3K30.88820997
61TIE10.86752132
62MAPK70.86541414
63IRAK10.86043411
64LRRK20.85011189
65PIM10.81554975
66SMG10.77682590
67TAOK30.77581191
68CDK40.75042097
69PDK10.74712654
70YES10.74318089
71MATK0.73904698
72PIK3CG0.73088046
73STK240.72054332
74CDK60.71729517
75LYN0.70733263
76MARK30.69201065
77MAPK40.68864720
78MAP3K10.68782085
79CDK90.67870204
80MAP2K30.67346601
81SGK30.65813965
82MARK20.65206099
83MTOR0.64884905
84IRAK20.64760829
85PIM20.64513270
86TRIB30.62886379
87GRK70.62792986
88RPS6KB20.62640240
89LATS10.61121734
90SIK30.60338844
91MAPK120.59869476
92KSR20.59787208
93PDGFRB0.59463229
94MAPKAPK20.58819522
95WNK10.58223451
96PDPK10.57731420
97TTN0.57383839
98PRKCH0.56538779
99CLK10.56012994
100AKT30.55759442
101GRK60.55676607
102PRKCQ0.55664954
103SIK10.55647074
104FES0.55481861
105SGK20.54020556
106MAPKAPK30.53162187
107MELK0.52456010
108TYRO30.50325842
109NEK90.50202969
110PRKAA20.50007094
111ABL10.49756774
112RPS6KL10.49429436
113RPS6KC10.49429436
114SIK20.49395784
115DYRK1B0.48657124
116EGFR0.46778576
117PKN20.46637821
118RPS6KA20.46465506
119MAP3K110.45181850
120MAP3K70.44999480
121TRPM70.43519889
122FRK0.42829440
123BMPR20.42508760
124ARAF0.42481709
125RET0.42101542
126PRKD10.41286201
127STK30.40823833
128BRD40.40086407
129PRKD20.39417567
130MAP3K50.38663881
131PDGFRA0.38504103
132TAOK10.36555984
133INSR0.36423784
134STK40.35964012
135PAK40.35933997

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.54922638
2Primary immunodeficiency_Homo sapiens_hsa053402.54255909
3Leishmaniasis_Homo sapiens_hsa051402.53851561
4Osteoclast differentiation_Homo sapiens_hsa043802.32092193
5B cell receptor signaling pathway_Homo sapiens_hsa046622.19035271
6Measles_Homo sapiens_hsa051622.02028336
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.00782948
8Intestinal immune network for IgA production_Homo sapiens_hsa046721.96493492
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96197964
10Antigen processing and presentation_Homo sapiens_hsa046121.94085955
11Toxoplasmosis_Homo sapiens_hsa051451.86173611
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81000741
13TNF signaling pathway_Homo sapiens_hsa046681.80935388
14Allograft rejection_Homo sapiens_hsa053301.78073054
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64482638
16Graft-versus-host disease_Homo sapiens_hsa053321.62172376
17Influenza A_Homo sapiens_hsa051641.57457435
18Hematopoietic cell lineage_Homo sapiens_hsa046401.56361783
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.55451156
20T cell receptor signaling pathway_Homo sapiens_hsa046601.51610197
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.49826516
22Herpes simplex infection_Homo sapiens_hsa051681.48678682
23Malaria_Homo sapiens_hsa051441.44215837
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.43705186
25Viral myocarditis_Homo sapiens_hsa054161.42721240
26Legionellosis_Homo sapiens_hsa051341.40001807
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.39623531
28Tuberculosis_Homo sapiens_hsa051521.38817449
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35603802
30Hepatitis B_Homo sapiens_hsa051611.34624682
31Chemokine signaling pathway_Homo sapiens_hsa040621.34595624
32Pertussis_Homo sapiens_hsa051331.33826680
33Apoptosis_Homo sapiens_hsa042101.33617117
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32589672
35Staphylococcus aureus infection_Homo sapiens_hsa051501.31089919
36Acute myeloid leukemia_Homo sapiens_hsa052211.24475925
37Pancreatic cancer_Homo sapiens_hsa052121.22871578
38Chronic myeloid leukemia_Homo sapiens_hsa052201.22844170
39Small cell lung cancer_Homo sapiens_hsa052221.22669260
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19119607
41Type I diabetes mellitus_Homo sapiens_hsa049401.18920245
42African trypanosomiasis_Homo sapiens_hsa051431.18458100
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16792210
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.12354218
45Prolactin signaling pathway_Homo sapiens_hsa049171.07634677
46Hepatitis C_Homo sapiens_hsa051601.06549586
47Shigellosis_Homo sapiens_hsa051311.06157873
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04074817
49Adherens junction_Homo sapiens_hsa045201.03393078
50Amoebiasis_Homo sapiens_hsa051461.03036826
51Asthma_Homo sapiens_hsa053101.02462467
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00769747
53Autoimmune thyroid disease_Homo sapiens_hsa053200.98329906
54Platelet activation_Homo sapiens_hsa046110.93498571
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91879728
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90999772
57Salmonella infection_Homo sapiens_hsa051320.90387100
58Bladder cancer_Homo sapiens_hsa052190.89645247
59Notch signaling pathway_Homo sapiens_hsa043300.89448552
60Rheumatoid arthritis_Homo sapiens_hsa053230.88784149
61Type II diabetes mellitus_Homo sapiens_hsa049300.86887161
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.86065110
63Insulin resistance_Homo sapiens_hsa049310.83230661
64ErbB signaling pathway_Homo sapiens_hsa040120.82694747
65Focal adhesion_Homo sapiens_hsa045100.82479404
66HTLV-I infection_Homo sapiens_hsa051660.82416243
67Lysosome_Homo sapiens_hsa041420.78867592
68Dorso-ventral axis formation_Homo sapiens_hsa043200.78055887
69Proteoglycans in cancer_Homo sapiens_hsa052050.77116338
70Glioma_Homo sapiens_hsa052140.74935038
71VEGF signaling pathway_Homo sapiens_hsa043700.73577816
72MicroRNAs in cancer_Homo sapiens_hsa052060.72464301
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71612943
74Other glycan degradation_Homo sapiens_hsa005110.70483259
75Viral carcinogenesis_Homo sapiens_hsa052030.70337059
76Prion diseases_Homo sapiens_hsa050200.68830445
77Colorectal cancer_Homo sapiens_hsa052100.67088316
78Phagosome_Homo sapiens_hsa041450.66446685
79Systemic lupus erythematosus_Homo sapiens_hsa053220.65307243
80Prostate cancer_Homo sapiens_hsa052150.65232939
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64331778
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64089879
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.63511710
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.62602980
85Renal cell carcinoma_Homo sapiens_hsa052110.61136698
86GnRH signaling pathway_Homo sapiens_hsa049120.60765354
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60305274
88Choline metabolism in cancer_Homo sapiens_hsa052310.59583589
89MAPK signaling pathway_Homo sapiens_hsa040100.59331613
90ECM-receptor interaction_Homo sapiens_hsa045120.59182589
91Pathways in cancer_Homo sapiens_hsa052000.57411830
92Epstein-Barr virus infection_Homo sapiens_hsa051690.56862972
93FoxO signaling pathway_Homo sapiens_hsa040680.56504124
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56286496
95mTOR signaling pathway_Homo sapiens_hsa041500.55324800
96Estrogen signaling pathway_Homo sapiens_hsa049150.55185457
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53727637
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50413318
99Endometrial cancer_Homo sapiens_hsa052130.50233278
100Non-small cell lung cancer_Homo sapiens_hsa052230.49809231
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.49553529
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49412683
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.48547851
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47953597
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47496841
106Endocytosis_Homo sapiens_hsa041440.47313777
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47310829
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46883446
109Rap1 signaling pathway_Homo sapiens_hsa040150.44484794
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44340092
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44285677
112Inositol phosphate metabolism_Homo sapiens_hsa005620.43798708
113Complement and coagulation cascades_Homo sapiens_hsa046100.42723278
114HIF-1 signaling pathway_Homo sapiens_hsa040660.42223834

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