LRCH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the leucine-rich repeat and calponin homology domain-containing protein family. These family members contain multiple N-terminal leucine-rich repeats, in addition to a C-terminal calponin homology domain, a type of domain that mediates interactions with actin filaments. These proteins are conserved across animal species, and studies of a similar Drosophila protein indicate a function as a cytoskeletal scaffolding protein. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)4.98020958
2dendritic spine morphogenesis (GO:0060997)4.69658922
3neuron recognition (GO:0008038)4.57185453
4nucleobase catabolic process (GO:0046113)4.53546880
5layer formation in cerebral cortex (GO:0021819)4.36381823
6axonal fasciculation (GO:0007413)4.34627162
7presynaptic membrane assembly (GO:0097105)4.31695911
8vocalization behavior (GO:0071625)4.31681748
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.28093493
10presynaptic membrane organization (GO:0097090)4.12979397
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.10669992
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.08829954
13locomotory exploration behavior (GO:0035641)4.03727728
14protein localization to synapse (GO:0035418)3.99885325
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97519133
16regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.91968138
17ionotropic glutamate receptor signaling pathway (GO:0035235)3.90178775
18regulation of glutamate receptor signaling pathway (GO:1900449)3.76192571
19cell migration in hindbrain (GO:0021535)3.75209648
20dendrite morphogenesis (GO:0048813)3.65216575
21glutamate receptor signaling pathway (GO:0007215)3.63986876
22exploration behavior (GO:0035640)3.59792818
23central nervous system projection neuron axonogenesis (GO:0021952)3.59784013
24positive regulation of synapse assembly (GO:0051965)3.56325147
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.54227390
26synaptic vesicle exocytosis (GO:0016079)3.53578684
27regulation of dendritic spine morphogenesis (GO:0061001)3.51501414
28postsynaptic membrane organization (GO:0001941)3.50487755
29cerebral cortex radially oriented cell migration (GO:0021799)3.47984461
30neurotransmitter-gated ion channel clustering (GO:0072578)3.41013872
31transmission of nerve impulse (GO:0019226)3.40851917
32retinal ganglion cell axon guidance (GO:0031290)3.40789642
33axon ensheathment in central nervous system (GO:0032291)3.39451150
34central nervous system myelination (GO:0022010)3.39451150
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.31515433
36regulation of synaptic vesicle exocytosis (GO:2000300)3.31254576
37synaptic transmission, glutamatergic (GO:0035249)3.31166029
38positive regulation of dendritic spine morphogenesis (GO:0061003)3.29720959
39synaptic vesicle maturation (GO:0016188)3.29571765
40neuron-neuron synaptic transmission (GO:0007270)3.28743275
41negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.24877504
42regulation of synapse structural plasticity (GO:0051823)3.23670770
43auditory behavior (GO:0031223)3.22445670
44spinal cord development (GO:0021510)3.19625187
45regulation of respiratory system process (GO:0044065)3.19561609
46behavioral response to nicotine (GO:0035095)3.18425001
47neural tube formation (GO:0001841)3.13852725
48regulation of neuronal synaptic plasticity (GO:0048168)3.13614917
49innervation (GO:0060384)3.13554605
50proline transport (GO:0015824)3.13280529
51establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.07997960
52mitochondrion transport along microtubule (GO:0047497)3.07997960
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06879375
54glutamate secretion (GO:0014047)3.04610124
55neuronal action potential propagation (GO:0019227)3.03117199
56regulation of synapse assembly (GO:0051963)3.02597758
57synapse assembly (GO:0007416)3.02217882
58behavioral response to ethanol (GO:0048149)3.00578593
59regulation of excitatory postsynaptic membrane potential (GO:0060079)2.98865996
60central nervous system neuron axonogenesis (GO:0021955)2.98017129
61negative regulation of axon guidance (GO:1902668)2.95992858
62gamma-aminobutyric acid transport (GO:0015812)2.95460579
63gamma-aminobutyric acid signaling pathway (GO:0007214)2.95422049
64positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95148511
65axon extension (GO:0048675)2.93749453
66regulation of postsynaptic membrane potential (GO:0060078)2.93204611
67regulation of respiratory gaseous exchange (GO:0043576)2.92815704
68cardiac ventricle formation (GO:0003211)2.92748638
69pyrimidine nucleobase catabolic process (GO:0006208)2.92541415
70dendrite development (GO:0016358)2.92338671
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90588198
72dendritic spine organization (GO:0097061)2.90180587
73intraciliary transport (GO:0042073)2.90175263
74positive regulation of dendritic spine development (GO:0060999)2.89982397
75startle response (GO:0001964)2.88627628
76regulation of dendritic spine development (GO:0060998)2.88623056
77nonmotile primary cilium assembly (GO:0035058)2.88246654
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87010219
79neurotransmitter secretion (GO:0007269)2.86119682
80synapse organization (GO:0050808)2.85273566
81mechanosensory behavior (GO:0007638)2.84400342
82long-term memory (GO:0007616)2.83214735
83regulation of synapse organization (GO:0050807)2.81871307
84protein localization to cilium (GO:0061512)2.81049762
85negative regulation of synaptic transmission, GABAergic (GO:0032229)2.80694246
86olfactory bulb development (GO:0021772)2.80002974
87mating behavior (GO:0007617)2.78859157
88cerebellar granule cell differentiation (GO:0021707)2.78645088
89positive regulation of synapse maturation (GO:0090129)2.78379403
90negative regulation of microtubule polymerization (GO:0031115)2.78040866
91axon extension involved in axon guidance (GO:0048846)2.78024579
92neuron projection extension involved in neuron projection guidance (GO:1902284)2.78024579
93establishment of mitochondrion localization (GO:0051654)2.77662072
94cardiac chamber formation (GO:0003207)2.76763856
95establishment of nucleus localization (GO:0040023)2.76030641
96regulation of synaptic vesicle transport (GO:1902803)2.75290634
97negative regulation of axon extension (GO:0030517)2.75150065
98regulation of synaptic transmission, glutamatergic (GO:0051966)2.74785057
99sympathetic nervous system development (GO:0048485)2.72931592
100synaptic vesicle docking involved in exocytosis (GO:0016081)2.71700496
101behavioral defense response (GO:0002209)2.71449561
102behavioral fear response (GO:0001662)2.71449561
103regulation of axon guidance (GO:1902667)2.71161409
104limb bud formation (GO:0060174)2.69913030
105response to pheromone (GO:0019236)2.69755157
106somite development (GO:0061053)2.68895919
107response to auditory stimulus (GO:0010996)2.66682650
108neuronal ion channel clustering (GO:0045161)2.65011290
109response to histamine (GO:0034776)2.64589689
110head development (GO:0060322)2.62978986
111negative regulation of neurotransmitter transport (GO:0051589)2.62553106
112positive regulation of membrane potential (GO:0045838)2.62241867
113membrane hyperpolarization (GO:0060081)2.61254754
114regulation of dendrite morphogenesis (GO:0048814)2.61012440
115regulation of synaptic transmission, GABAergic (GO:0032228)2.60174792
116hippocampus development (GO:0021766)2.59763520
117regulation of vesicle fusion (GO:0031338)2.57814437
118neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.57637852
119calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.56921384
120neuron migration (GO:0001764)2.56532866
121organelle transport along microtubule (GO:0072384)2.55871986
122neuromuscular process controlling balance (GO:0050885)2.55400621
123fear response (GO:0042596)2.54406944
124synaptic vesicle endocytosis (GO:0048488)2.54055929
125negative chemotaxis (GO:0050919)2.53933768
126kidney morphogenesis (GO:0060993)2.52851758
127cerebral cortex cell migration (GO:0021795)2.52583969
128positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.52229682
129neuron projection extension (GO:1990138)2.48248701
130negative regulation of axon extension involved in axon guidance (GO:0048843)2.47555996
131regulation of cilium movement (GO:0003352)2.39931854
132regulation of axon extension involved in axon guidance (GO:0048841)2.38788432
133pancreas development (GO:0031016)2.36704301
134forebrain neuron differentiation (GO:0021879)2.36632843
135artery development (GO:0060840)2.35919009
136negative regulation of translation, ncRNA-mediated (GO:0040033)2.33253953
137regulation of translation, ncRNA-mediated (GO:0045974)2.33253953
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.33253953
139embryonic foregut morphogenesis (GO:0048617)2.33229627
140negative regulation of axonogenesis (GO:0050771)2.31854919
141hindbrain development (GO:0030902)2.31650474
142retinal cone cell development (GO:0046549)2.30719728
143ganglion development (GO:0061548)2.27808177
144glycosphingolipid biosynthetic process (GO:0006688)2.27648228
145positive regulation of neurological system process (GO:0031646)2.27371350
146heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.26728981
147regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.26255115
148ephrin receptor signaling pathway (GO:0048013)2.26227057
149limb development (GO:0060173)2.25983679
150appendage development (GO:0048736)2.25983679
151brain morphogenesis (GO:0048854)2.25450610
152protein polyglutamylation (GO:0018095)2.25152530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47535003
2GBX2_23144817_ChIP-Seq_PC3_Human3.80399126
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97578801
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83436454
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82510989
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.81539688
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58261019
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58261019
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.53762123
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46973692
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46358228
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45892805
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44443661
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40175639
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.20171896
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.19330476
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18976956
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.16801385
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09150573
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07392823
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.02523500
22* REST_21632747_ChIP-Seq_MESCs_Mouse2.00438804
23TAF15_26573619_Chip-Seq_HEK293_Human1.99819227
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97025190
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95738970
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94988115
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90774879
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88887592
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88849251
30FUS_26573619_Chip-Seq_HEK293_Human1.87436402
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86663723
32AR_21572438_ChIP-Seq_LNCaP_Human1.84786343
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83136569
34RNF2_27304074_Chip-Seq_NSC_Mouse1.78324406
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75745559
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67147064
37P300_19829295_ChIP-Seq_ESCs_Human1.65472050
38DROSHA_22980978_ChIP-Seq_HELA_Human1.63640467
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63362868
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.62335794
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.61933902
42SMAD4_21799915_ChIP-Seq_A2780_Human1.60734581
43ZNF274_21170338_ChIP-Seq_K562_Hela1.59492208
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58893957
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58659195
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57541128
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56032650
48IGF1R_20145208_ChIP-Seq_DFB_Human1.55249646
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52788028
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.52197091
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49839405
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.48134326
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.47752245
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.44997124
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44844746
56RING1B_27294783_Chip-Seq_NPCs_Mouse1.43589940
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43308472
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39664157
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.38605939
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.34664319
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33097623
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31687603
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27189626
64CBP_20019798_ChIP-Seq_JUKART_Human1.27189626
65ER_23166858_ChIP-Seq_MCF-7_Human1.25930419
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.23668966
67EWS_26573619_Chip-Seq_HEK293_Human1.21750850
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20742712
69STAT3_23295773_ChIP-Seq_U87_Human1.19565105
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19253166
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18785194
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18300665
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18196676
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18196676
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17091902
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16998925
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.16606167
78AR_25329375_ChIP-Seq_VCAP_Human1.15911709
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14718174
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14296218
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.13559971
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.13040213
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12870255
84RUNX2_22187159_ChIP-Seq_PCA_Human1.11985267
85VDR_22108803_ChIP-Seq_LS180_Human1.11935756
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11247540
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10960731
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10882585
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10637120
90BCAT_22108803_ChIP-Seq_LS180_Human1.10477668
91TP53_16413492_ChIP-PET_HCT116_Human1.10247292
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09929250
93TP53_18474530_ChIP-ChIP_U2OS_Human1.09724400
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09599982
95* WT1_19549856_ChIP-ChIP_CCG9911_Human1.09366610
96AR_19668381_ChIP-Seq_PC3_Human1.08723739
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07964156
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.07349832
99IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07292992
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07108801
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06606124
102TCF4_23295773_ChIP-Seq_U87_Human1.05737976
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04742524
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03997417
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.03753679
106AHR_22903824_ChIP-Seq_MCF-7_Human1.03516466
107P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02596763
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02378283
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01961197
110JUN_21703547_ChIP-Seq_K562_Human1.01760312
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.01287160
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01230798
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.00808550
114TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00763110
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00600529
116SOX9_26525672_Chip-Seq_HEART_Mouse1.00308338
117TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00206171
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.99942714
119WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99644800
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98684319
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98110379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.16271985
2MP0004859_abnormal_synaptic_plasticity3.99510757
3MP0005423_abnormal_somatic_nervous3.02203583
4MP0003635_abnormal_synaptic_transmissio3.00890385
5MP0004270_analgesia2.93576307
6MP0000778_abnormal_nervous_system2.69114091
7MP0002063_abnormal_learning/memory/cond2.52157576
8MP0009745_abnormal_behavioral_response2.42678106
9MP0003122_maternal_imprinting2.22733163
10MP0002064_seizures2.21760540
11MP0002572_abnormal_emotion/affect_behav2.11264707
12MP0009046_muscle_twitch2.11199401
13MP0001486_abnormal_startle_reflex2.11155384
14MP0002184_abnormal_innervation2.03793436
15MP0002734_abnormal_mechanical_nocicepti1.96790123
16MP0001968_abnormal_touch/_nociception1.89680644
17MP0002272_abnormal_nervous_system1.88483598
18MP0001188_hyperpigmentation1.74117014
19MP0001529_abnormal_vocalization1.73020238
20MP0006276_abnormal_autonomic_nervous1.72016073
21MP0003787_abnormal_imprinting1.68661385
22MP0001440_abnormal_grooming_behavior1.68466904
23MP0000537_abnormal_urethra_morphology1.67733135
24MP0002557_abnormal_social/conspecific_i1.62320395
25MP0002822_catalepsy1.59458924
26MP0003121_genomic_imprinting1.59001812
27MP0002067_abnormal_sensory_capabilities1.55817111
28MP0000955_abnormal_spinal_cord1.53799406
29MP0004924_abnormal_behavior1.52291840
30MP0005386_behavior/neurological_phenoty1.52291840
31MP0002735_abnormal_chemical_nociception1.51950436
32MP0004885_abnormal_endolymph1.50347230
33MP0000569_abnormal_digit_pigmentation1.48852665
34MP0000631_abnormal_neuroendocrine_gland1.44477305
35MP0004811_abnormal_neuron_physiology1.43830065
36MP0002234_abnormal_pharynx_morphology1.42601329
37MP0002733_abnormal_thermal_nociception1.41261606
38MP0002882_abnormal_neuron_morphology1.41210135
39MP0008877_abnormal_DNA_methylation1.38926131
40MP0002152_abnormal_brain_morphology1.36523222
41MP0005409_darkened_coat_color1.33644531
42MP0002736_abnormal_nociception_after1.32270647
43MP0003385_abnormal_body_wall1.30830128
44MP0005187_abnormal_penis_morphology1.29557911
45MP0001970_abnormal_pain_threshold1.29010124
46MP0009780_abnormal_chondrocyte_physiolo1.27992101
47MP0003861_abnormal_nervous_system1.26043734
48MP0002638_abnormal_pupillary_reflex1.23652658
49MP0001293_anophthalmia1.20725030
50MP0006292_abnormal_olfactory_placode1.20319336
51MP0001299_abnormal_eye_distance/1.17804482
52MP0000049_abnormal_middle_ear1.17551028
53MP0005623_abnormal_meninges_morphology1.17476264
54MP0005503_abnormal_tendon_morphology1.15067317
55MP0000516_abnormal_urinary_system1.14860194
56MP0005367_renal/urinary_system_phenotyp1.14860194
57MP0005171_absent_coat_pigmentation1.14802376
58MP0002066_abnormal_motor_capabilities/c1.14791101
59MP0008569_lethality_at_weaning1.14766438
60MP0001485_abnormal_pinna_reflex1.14675842
61MP0003123_paternal_imprinting1.14341924
62MP0001501_abnormal_sleep_pattern1.12180820
63MP0001905_abnormal_dopamine_level1.12056466
64MP0005645_abnormal_hypothalamus_physiol1.10532526
65MP0009379_abnormal_foot_pigmentation1.10272794
66MP0003938_abnormal_ear_development1.10070327
67MP0004858_abnormal_nervous_system1.08687589
68MP0004742_abnormal_vestibular_system1.08542960
69MP0000566_synostosis1.08488721
70MP0001286_abnormal_eye_development1.08218816
71MP0003937_abnormal_limbs/digits/tail_de1.08097942
72MP0004145_abnormal_muscle_electrophysio1.07560558
73MP0003935_abnormal_craniofacial_develop1.07501838
74MP0009250_abnormal_appendicular_skeleto1.07159458
75MP0003942_abnormal_urinary_system1.07043417
76MP0002697_abnormal_eye_size1.05757407
77MP0005646_abnormal_pituitary_gland1.05260067
78MP0002751_abnormal_autonomic_nervous1.05004871
79MP0004142_abnormal_muscle_tone1.04584161
80MP0005499_abnormal_olfactory_system1.02624963
81MP0005394_taste/olfaction_phenotype1.02624963
82MP0002752_abnormal_somatic_nervous1.01712918
83MP0003119_abnormal_digestive_system1.01355368
84MP0006072_abnormal_retinal_apoptosis0.99297787
85MP0001984_abnormal_olfaction0.98145845
86MP0003755_abnormal_palate_morphology0.97985111
87MP0002102_abnormal_ear_morphology0.96996031
88MP0008789_abnormal_olfactory_epithelium0.96974618
89MP0001177_atelectasis0.96630637
90MP0005195_abnormal_posterior_eye0.95817617
91MP0005253_abnormal_eye_physiology0.95024449
92MP0003137_abnormal_impulse_conducting0.93920138
93MP0000751_myopathy0.93677726
94MP0003283_abnormal_digestive_organ0.93653913
95MP0000534_abnormal_ureter_morphology0.93536396
96MP0001963_abnormal_hearing_physiology0.90612273
97MP0002938_white_spotting0.89530923
98MP0000026_abnormal_inner_ear0.89500480
99MP0003634_abnormal_glial_cell0.88322826
100MP0003329_amyloid_beta_deposits0.88118456
101MP0002116_abnormal_craniofacial_bone0.85827059
102MP0005391_vision/eye_phenotype0.84867600
103MP0004085_abnormal_heartbeat0.84733766
104MP0004133_heterotaxia0.84613105
105MP0005551_abnormal_eye_electrophysiolog0.83037428
106MP0003890_abnormal_embryonic-extraembry0.82977993
107MP0002081_perinatal_lethality0.82942821
108MP0010030_abnormal_orbit_morphology0.81022186
109MP0003315_abnormal_perineum_morphology0.80220256
110MP0001502_abnormal_circadian_rhythm0.79910387
111MP0005248_abnormal_Harderian_gland0.79678098
112MP0000428_abnormal_craniofacial_morphol0.78965548
113MP0002233_abnormal_nose_morphology0.78756297
114MP0003879_abnormal_hair_cell0.78123607
115MP0001943_abnormal_respiration0.77287697
116MP0009053_abnormal_anal_canal0.75987993
117MP0003567_abnormal_fetal_cardiomyocyte0.75517296
118MP0001346_abnormal_lacrimal_gland0.75355904
119MP0002282_abnormal_trachea_morphology0.71215184
120MP0002109_abnormal_limb_morphology0.70556521

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.33543835
2Myokymia (HP:0002411)3.67807303
3Focal seizures (HP:0007359)3.56880501
4Broad-based gait (HP:0002136)3.03548285
5Abnormality of the corticospinal tract (HP:0002492)2.99596256
6Pancreatic fibrosis (HP:0100732)2.90337225
7Atonic seizures (HP:0010819)2.86788583
8Epileptic encephalopathy (HP:0200134)2.83024245
9Nephronophthisis (HP:0000090)2.78435634
10Drooling (HP:0002307)2.78224355
11Excessive salivation (HP:0003781)2.78224355
12Degeneration of the lateral corticospinal tracts (HP:0002314)2.77975745
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.77975745
14Termporal pattern (HP:0011008)2.76092699
15Insidious onset (HP:0003587)2.76092699
16Intestinal atresia (HP:0011100)2.69857889
17Visual hallucinations (HP:0002367)2.67351980
18Progressive cerebellar ataxia (HP:0002073)2.66027580
19Hyperventilation (HP:0002883)2.65305504
20Medial flaring of the eyebrow (HP:0010747)2.59006368
21True hermaphroditism (HP:0010459)2.57807931
22Pancreatic cysts (HP:0001737)2.57607117
23Absence seizures (HP:0002121)2.54420217
24Molar tooth sign on MRI (HP:0002419)2.53416308
25Abnormality of midbrain morphology (HP:0002418)2.53416308
26Amyotrophic lateral sclerosis (HP:0007354)2.46987351
27Febrile seizures (HP:0002373)2.39874100
28Hemiparesis (HP:0001269)2.38219187
29Megalencephaly (HP:0001355)2.37972562
30Lissencephaly (HP:0001339)2.33088711
31Cortical dysplasia (HP:0002539)2.31007354
32Congenital primary aphakia (HP:0007707)2.30878947
33Generalized tonic-clonic seizures (HP:0002069)2.30788374
34Dialeptic seizures (HP:0011146)2.28962187
35Amblyopia (HP:0000646)2.25820803
36Abnormality of the renal medulla (HP:0100957)2.25455899
37Pachygyria (HP:0001302)2.25403692
38Buphthalmos (HP:0000557)2.24232344
39Truncal ataxia (HP:0002078)2.24214087
40Limb dystonia (HP:0002451)2.22866016
41Optic nerve hypoplasia (HP:0000609)2.22034392
42Action tremor (HP:0002345)2.21700221
43Volvulus (HP:0002580)2.20857050
44Cerebellar dysplasia (HP:0007033)2.20737191
45Polyphagia (HP:0002591)2.18323084
46Narrow forehead (HP:0000341)2.16443325
47Cerebral inclusion bodies (HP:0100314)2.14178303
48Coronal craniosynostosis (HP:0004440)2.12440375
49Impaired vibration sensation in the lower limbs (HP:0002166)2.12097389
50Papilledema (HP:0001085)2.10404359
51Ankle clonus (HP:0011448)2.08195151
52Absent speech (HP:0001344)2.07994237
53Postaxial hand polydactyly (HP:0001162)2.07508755
54Supranuclear gaze palsy (HP:0000605)2.06716913
55Cutaneous finger syndactyly (HP:0010554)2.04691138
56Agitation (HP:0000713)2.04419673
57Aqueductal stenosis (HP:0002410)2.02092028
58Shoulder girdle muscle weakness (HP:0003547)2.02060213
59Nephrogenic diabetes insipidus (HP:0009806)2.01393196
60Occipital encephalocele (HP:0002085)2.01250481
61Type II lissencephaly (HP:0007260)2.00893285
62Anencephaly (HP:0002323)2.00566279
63Abnormality of the labia minora (HP:0012880)2.00466604
64Neurofibrillary tangles (HP:0002185)1.99326518
65Septo-optic dysplasia (HP:0100842)1.98860478
66Morphological abnormality of the middle ear (HP:0008609)1.98073787
67Poor coordination (HP:0002370)1.97165820
68Postaxial foot polydactyly (HP:0001830)1.97097769
69Hepatoblastoma (HP:0002884)1.95379553
70Chronic hepatic failure (HP:0100626)1.93908140
71Gastrointestinal atresia (HP:0002589)1.93207598
72Spastic gait (HP:0002064)1.92842094
73Mutism (HP:0002300)1.92632487
74Gaze-evoked nystagmus (HP:0000640)1.92548087
75Gait imbalance (HP:0002141)1.90167803
76Intellectual disability, moderate (HP:0002342)1.89814018
77High anterior hairline (HP:0009890)1.89587630
78Poor eye contact (HP:0000817)1.89531591
79Urinary bladder sphincter dysfunction (HP:0002839)1.89360764
80Progressive inability to walk (HP:0002505)1.88826597
81Vitreoretinal degeneration (HP:0000655)1.88664590
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88167191
83Bifid tongue (HP:0010297)1.87794610
84Short 4th metacarpal (HP:0010044)1.87422589
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87422589
86Renal hypoplasia (HP:0000089)1.87041653
87Dysdiadochokinesis (HP:0002075)1.87025719
88Urinary urgency (HP:0000012)1.86967176
89Supernumerary spleens (HP:0009799)1.86460224
90Abnormality of the lower motor neuron (HP:0002366)1.83898781
91Scanning speech (HP:0002168)1.83673567
92Midline defect of the nose (HP:0004122)1.83325749
93Anophthalmia (HP:0000528)1.83094652
94Aplasia involving bones of the extremities (HP:0009825)1.81895200
95Aplasia involving bones of the upper limbs (HP:0009823)1.81895200
96Aplasia of the phalanges of the hand (HP:0009802)1.81895200
97Abnormality of salivation (HP:0100755)1.80586269
98Oligodactyly (hands) (HP:0001180)1.79784663
99Preaxial hand polydactyly (HP:0001177)1.79038637
100Inappropriate behavior (HP:0000719)1.78986892
101Exotropia (HP:0000577)1.77406742
102Micropenis (HP:0000054)1.76560055
103Anxiety (HP:0000739)1.76299056
104Anterior segment dysgenesis (HP:0007700)1.75525433
105Depression (HP:0000716)1.74538282
106Bronchomalacia (HP:0002780)1.74320286
107Pheochromocytoma (HP:0002666)1.73801337
108Small hand (HP:0200055)1.73646329
109Genetic anticipation (HP:0003743)1.73386096
110Gastroesophageal reflux (HP:0002020)1.72834780
111Protruding tongue (HP:0010808)1.71995561
112Cutaneous syndactyly (HP:0012725)1.71866740
113Short foot (HP:0001773)1.71468045
114Aplasia/Hypoplasia of the tongue (HP:0010295)1.70775481
115Specific learning disability (HP:0001328)1.70739941
116Macroorchidism (HP:0000053)1.70700457
117Shallow orbits (HP:0000586)1.70687465
118Sclerocornea (HP:0000647)1.70668194
119Cystic liver disease (HP:0006706)1.70464657
120Lower limb muscle weakness (HP:0007340)1.70090071
121Polymicrogyria (HP:0002126)1.69865862
122Hypoventilation (HP:0002791)1.68974937
123Retinal dysplasia (HP:0007973)1.67274074
124Hyperthyroidism (HP:0000836)1.67154840
125Inability to walk (HP:0002540)1.67058585
126Thickened helices (HP:0000391)1.66302215
127Omphalocele (HP:0001539)1.64987578
128Epileptiform EEG discharges (HP:0011182)1.64723943
129Colon cancer (HP:0003003)1.64072579
130Dysmetria (HP:0001310)1.64044554
131Preaxial foot polydactyly (HP:0001841)1.63795265
132Microglossia (HP:0000171)1.63578538
133Hypoplasia of the brainstem (HP:0002365)1.63364942
134Aplasia/Hypoplasia of the brainstem (HP:0007362)1.63364942
135Patellar aplasia (HP:0006443)1.63279517
136EEG with generalized epileptiform discharges (HP:0011198)1.62610465
137Sacral dimple (HP:0000960)1.62563792
138Highly arched eyebrow (HP:0002553)1.62327137
139Abnormality of the antihelix (HP:0009738)1.62308247
140Cupped ear (HP:0000378)1.61108682
141Abnormality of binocular vision (HP:0011514)1.61030538
142Diplopia (HP:0000651)1.61030538
143Impaired social interactions (HP:0000735)1.60956858
144Abnormal social behavior (HP:0012433)1.60956858
145Ankyloglossia (HP:0010296)1.59719015
146Prominent nasal bridge (HP:0000426)1.58747605
147Genital tract atresia (HP:0001827)1.57210538
148Absent eyebrow (HP:0002223)1.56705930
149Abnormality of the ischium (HP:0003174)1.56573099
150Hypsarrhythmia (HP:0002521)1.56169760
151Dandy-Walker malformation (HP:0001305)1.55954302
152Shawl scrotum (HP:0000049)1.55622379
153Alacrima (HP:0000522)1.54624124
154Autism (HP:0000717)1.54113253
155Sleep apnea (HP:0010535)1.52663114
156Vaginal atresia (HP:0000148)1.52618594
157Asymmetry of the thorax (HP:0001555)1.52586295
158Long nose (HP:0003189)1.51493961
159Narrow nasal bridge (HP:0000446)1.50245857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.80092536
2NTRK33.51864896
3EPHA43.23662536
4CASK2.91280651
5MAP3K42.69851210
6MAP3K92.38531060
7NTRK22.32339532
8MAPK132.16245297
9PNCK2.16116016
10MINK11.97443504
11MAP2K71.97319793
12PINK11.91159439
13FGFR21.84980571
14KSR11.81509236
15PLK21.77779326
16UHMK11.76738321
17PAK61.76345496
18ERBB31.70160933
19LATS11.62535752
20TNIK1.58352390
21TYRO31.55642667
22ACVR1B1.47126198
23LATS21.39782662
24BCR1.38237430
25DYRK21.37145965
26EPHB21.32800276
27MAP2K41.29361662
28CSNK1G21.26458388
29CDK51.23416724
30WNK31.20805380
31NUAK11.18338886
32SIK21.18035414
33DYRK31.15139512
34MAP4K21.14669517
35OXSR11.13653238
36BRD41.12012078
37PHKG21.11337720
38PHKG11.11337720
39NTRK11.10299924
40PAK31.07704375
41CSNK1G31.06167411
42STK391.05858839
43CSNK1A1L1.04539550
44CDK191.01616761
45PKN11.01132582
46PRKD31.01021359
47DDR21.00423956
48CAMK2A0.99192406
49CAMK2B0.96763020
50CDK140.96184900
51LIMK10.95807351
52PRKCG0.94767361
53FGR0.94592285
54CDK180.93888609
55TRIM280.93611716
56PLK40.93507865
57DYRK1A0.91931778
58CDK150.91850787
59KSR20.89997659
60DAPK20.89022348
61GRK50.85365951
62TGFBR10.84962971
63MKNK10.80759670
64STK110.79923697
65BMPR1B0.79399497
66ADRBK20.79086877
67CDK11A0.78842284
68WNK10.77719429
69ZAK0.75675635
70MARK20.75329946
71CAMK1G0.74581051
72SGK2230.74542909
73SGK4940.74542909
74CSNK1G10.71780387
75CAMKK10.71638793
76PLK30.71191793
77CDC70.69523746
78NEK60.69412875
79TLK10.68472213
80ROCK20.67122859
81MKNK20.66253719
82RIPK10.65999873
83PRPF4B0.65799203
84TAF10.65722044
85PTK2B0.65427351
86MAP3K120.63164685
87PDGFRA0.62659997
88MAP3K60.62116462
89CDK30.61200620
90VRK10.60541883
91SRPK10.60209894
92AKT30.59251534
93CAMK2D0.59051236
94WEE10.58041638
95ICK0.57733843
96STK38L0.57346406
97PRKCE0.57102182
98FRK0.56067027
99INSRR0.55656209
100NEK20.55346060
101FGFR10.54529930
102PRKCH0.53996472
103FES0.53843037
104YES10.53742473
105MAP3K20.52794397
106SGK10.52431829
107CDC42BPA0.51606009
108RET0.50924391
109CSNK1E0.50315803
110PIK3CA0.46717399
111MAPK100.46614717
112PRKCZ0.46266485
113ROCK10.46231949
114CSNK1D0.45035642
115EPHA30.44760751
116ADRBK10.43986473
117SGK20.43868863
118PRKG10.43390701
119CCNB10.42748627
120BRSK20.42613361
121RPS6KA30.40282974
122MAPK90.40016305
123CAMK10.39876506
124OBSCN0.39210998
125GRK10.38700989
126FER0.38659846
127FYN0.38144937
128ATM0.38111695
129DAPK10.37947064
130IRAK20.37132199
131TIE10.35249458
132STK30.32538411
133PRKDC0.32327915
134MAPK150.31548373
135PRKACB0.31481849
136CAMKK20.30298625

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.66632308
2GABAergic synapse_Homo sapiens_hsa047272.63980467
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62041370
4Glutamatergic synapse_Homo sapiens_hsa047242.53329007
5Circadian entrainment_Homo sapiens_hsa047132.41000984
6Morphine addiction_Homo sapiens_hsa050322.31548169
7Long-term potentiation_Homo sapiens_hsa047202.24095042
8Dopaminergic synapse_Homo sapiens_hsa047282.23497963
9Axon guidance_Homo sapiens_hsa043602.21961930
10Amphetamine addiction_Homo sapiens_hsa050312.12580168
11Synaptic vesicle cycle_Homo sapiens_hsa047212.04039210
12Serotonergic synapse_Homo sapiens_hsa047261.98818319
13Olfactory transduction_Homo sapiens_hsa047401.95836411
14Long-term depression_Homo sapiens_hsa047301.92293018
15Taste transduction_Homo sapiens_hsa047421.81731736
16Cholinergic synapse_Homo sapiens_hsa047251.79227888
17Cocaine addiction_Homo sapiens_hsa050301.72159533
18Salivary secretion_Homo sapiens_hsa049701.65805246
19Renin secretion_Homo sapiens_hsa049241.65775467
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65726021
21Insulin secretion_Homo sapiens_hsa049111.62810201
22Gap junction_Homo sapiens_hsa045401.62434925
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58509655
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.57754585
25Protein export_Homo sapiens_hsa030601.52485970
26Oxytocin signaling pathway_Homo sapiens_hsa049211.50270347
27Gastric acid secretion_Homo sapiens_hsa049711.47401220
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46371022
29Basal transcription factors_Homo sapiens_hsa030221.42730831
30GnRH signaling pathway_Homo sapiens_hsa049121.42023703
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39400955
32Melanogenesis_Homo sapiens_hsa049161.39069787
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37663942
34Steroid biosynthesis_Homo sapiens_hsa001001.33139177
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32941410
36Butanoate metabolism_Homo sapiens_hsa006501.32474446
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25577017
38Calcium signaling pathway_Homo sapiens_hsa040201.24222762
39Non-homologous end-joining_Homo sapiens_hsa034501.23612495
40Phototransduction_Homo sapiens_hsa047441.20100415
41Hedgehog signaling pathway_Homo sapiens_hsa043401.19554199
42ErbB signaling pathway_Homo sapiens_hsa040121.19063482
43Cardiac muscle contraction_Homo sapiens_hsa042601.18969799
44Oocyte meiosis_Homo sapiens_hsa041141.17171252
45Selenocompound metabolism_Homo sapiens_hsa004501.16929697
46Dorso-ventral axis formation_Homo sapiens_hsa043201.16435886
47Wnt signaling pathway_Homo sapiens_hsa043101.15789962
48Estrogen signaling pathway_Homo sapiens_hsa049151.14666096
49cAMP signaling pathway_Homo sapiens_hsa040241.10217000
50Glioma_Homo sapiens_hsa052141.06790248
51Fanconi anemia pathway_Homo sapiens_hsa034601.03594752
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02152697
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01991833
54Circadian rhythm_Homo sapiens_hsa047101.01828566
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01176065
56Basal cell carcinoma_Homo sapiens_hsa052171.00310704
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99610162
58Propanoate metabolism_Homo sapiens_hsa006400.98373969
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97914312
60Alcoholism_Homo sapiens_hsa050340.94679104
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.92201101
62Hippo signaling pathway_Homo sapiens_hsa043900.92146288
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91829654
64Renal cell carcinoma_Homo sapiens_hsa052110.91258397
65Type II diabetes mellitus_Homo sapiens_hsa049300.88817081
66Dilated cardiomyopathy_Homo sapiens_hsa054140.88608965
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88401018
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86648710
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83352190
70Lysine degradation_Homo sapiens_hsa003100.82631508
71Tight junction_Homo sapiens_hsa045300.82050331
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.81428666
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81352618
74Ras signaling pathway_Homo sapiens_hsa040140.81085254
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.81067560
76RNA degradation_Homo sapiens_hsa030180.80750396
77Choline metabolism in cancer_Homo sapiens_hsa052310.79243627
78MAPK signaling pathway_Homo sapiens_hsa040100.77021880
79Colorectal cancer_Homo sapiens_hsa052100.75706749
80Collecting duct acid secretion_Homo sapiens_hsa049660.73836940
81Thyroid hormone synthesis_Homo sapiens_hsa049180.73678800
82Rap1 signaling pathway_Homo sapiens_hsa040150.73103352
83Linoleic acid metabolism_Homo sapiens_hsa005910.72441678
84Vibrio cholerae infection_Homo sapiens_hsa051100.72220537
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70119611
86Alzheimers disease_Homo sapiens_hsa050100.69960715
87Endometrial cancer_Homo sapiens_hsa052130.64410162
88Ovarian steroidogenesis_Homo sapiens_hsa049130.63428736
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.62070561
90Melanoma_Homo sapiens_hsa052180.61882586
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60653809
92mRNA surveillance pathway_Homo sapiens_hsa030150.59805491
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59786176
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58248123
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58232430
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.57547767
97TGF-beta signaling pathway_Homo sapiens_hsa043500.57429513
98RNA transport_Homo sapiens_hsa030130.56930313
99VEGF signaling pathway_Homo sapiens_hsa043700.56505601
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56468304
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56143411
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54622231
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54536116
104Parkinsons disease_Homo sapiens_hsa050120.54076896
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53293894
106Ether lipid metabolism_Homo sapiens_hsa005650.51504177
107Pancreatic secretion_Homo sapiens_hsa049720.51070546
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49687257
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.47074618
110Oxidative phosphorylation_Homo sapiens_hsa001900.47032623
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46795645
112Caffeine metabolism_Homo sapiens_hsa002320.46763916
113Tryptophan metabolism_Homo sapiens_hsa003800.46359242
114Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45792088
115Nitrogen metabolism_Homo sapiens_hsa009100.44984246
116Huntingtons disease_Homo sapiens_hsa050160.44583387
117Protein digestion and absorption_Homo sapiens_hsa049740.44139190
118mTOR signaling pathway_Homo sapiens_hsa041500.43892662
119Adherens junction_Homo sapiens_hsa045200.43533485
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43254379
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43177747
122ECM-receptor interaction_Homo sapiens_hsa045120.42865779
123MicroRNAs in cancer_Homo sapiens_hsa052060.38238443
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37741640
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36953279
126Proteoglycans in cancer_Homo sapiens_hsa052050.36552030
127Focal adhesion_Homo sapiens_hsa045100.36413285
128Prion diseases_Homo sapiens_hsa050200.35641232
129Prostate cancer_Homo sapiens_hsa052150.35529342

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