LRCH3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.58555751
2response to pheromone (GO:0019236)4.11863646
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.97907607
4L-fucose catabolic process (GO:0042355)3.86541261
5fucose catabolic process (GO:0019317)3.86541261
6L-fucose metabolic process (GO:0042354)3.86541261
7cytoplasmic mRNA processing body assembly (GO:0033962)3.83892500
8indole-containing compound catabolic process (GO:0042436)3.71182878
9indolalkylamine catabolic process (GO:0046218)3.71182878
10tryptophan catabolic process (GO:0006569)3.71182878
11kynurenine metabolic process (GO:0070189)3.67871178
12neural tube formation (GO:0001841)3.66903135
13indolalkylamine metabolic process (GO:0006586)3.55736437
14gamma-aminobutyric acid transport (GO:0015812)3.54001713
15regulation of hippo signaling (GO:0035330)3.50709551
16positive regulation of gamma-delta T cell activation (GO:0046645)3.43837513
17pyrimidine nucleobase catabolic process (GO:0006208)3.37532480
18tryptophan metabolic process (GO:0006568)3.23796594
19somite development (GO:0061053)3.22785308
20primary amino compound metabolic process (GO:1901160)3.15800223
21regulation of gene silencing by RNA (GO:0060966)3.15610091
22regulation of posttranscriptional gene silencing (GO:0060147)3.15610091
23regulation of gene silencing by miRNA (GO:0060964)3.15610091
24interkinetic nuclear migration (GO:0022027)3.12775962
25epithelial cilium movement (GO:0003351)3.11626929
26cAMP catabolic process (GO:0006198)3.09611273
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.09429313
28regulation of nuclear cell cycle DNA replication (GO:0033262)3.06830061
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03966254
30spinal cord motor neuron differentiation (GO:0021522)3.03569307
31insulin-like growth factor receptor signaling pathway (GO:0048009)2.99090897
32detection of light stimulus involved in sensory perception (GO:0050962)2.95906901
33detection of light stimulus involved in visual perception (GO:0050908)2.95906901
34nephron tubule morphogenesis (GO:0072078)2.91432481
35nephron epithelium morphogenesis (GO:0072088)2.91432481
36histone H3-K9 demethylation (GO:0033169)2.91199578
37regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89722960
38sulfation (GO:0051923)2.88352068
39regulation of interleukin-12 biosynthetic process (GO:0045075)2.86869647
40protein K11-linked deubiquitination (GO:0035871)2.86547913
41neuronal action potential (GO:0019228)2.83647415
42cyclic nucleotide catabolic process (GO:0009214)2.82599527
43cellular response to sterol (GO:0036315)2.81845490
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80957758
45negative regulation of cell killing (GO:0031342)2.80957758
46regulation of telomere maintenance (GO:0032204)2.80130192
47cornea development in camera-type eye (GO:0061303)2.79078602
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77317355
49kidney morphogenesis (GO:0060993)2.76197845
50positive regulation of histone deacetylation (GO:0031065)2.76130021
51cilium morphogenesis (GO:0060271)2.75899473
52indole-containing compound metabolic process (GO:0042430)2.75510729
53regulation of T cell tolerance induction (GO:0002664)2.75262274
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73609906
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.73609906
56G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.72494834
57histone H3-K4 trimethylation (GO:0080182)2.70350939
58negative regulation of mast cell activation (GO:0033004)2.70097941
59regulation of gamma-delta T cell differentiation (GO:0045586)2.68650105
60cilium or flagellum-dependent cell motility (GO:0001539)2.64660253
61postsynaptic membrane organization (GO:0001941)2.64085397
62serotonin metabolic process (GO:0042428)2.63917062
63limb development (GO:0060173)2.63828179
64appendage development (GO:0048736)2.63828179
65negative T cell selection (GO:0043383)2.63271866
66rRNA catabolic process (GO:0016075)2.61640621
67positive regulation of CREB transcription factor activity (GO:0032793)2.61552124
68antigen processing and presentation of endogenous antigen (GO:0019883)2.61234567
69positive regulation of developmental pigmentation (GO:0048087)2.60979323
70negative thymic T cell selection (GO:0045060)2.60563119
71hindbrain development (GO:0030902)2.60490433
72nucleobase catabolic process (GO:0046113)2.59725082
73nonmotile primary cilium assembly (GO:0035058)2.59155244
74head development (GO:0060322)2.58448055
75membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.58264954
76olfactory bulb development (GO:0021772)2.58258831
77snRNA transcription (GO:0009301)2.58122788
78negative regulation of telomere maintenance (GO:0032205)2.56604835
79cellular ketone body metabolic process (GO:0046950)2.56121950
80cilium movement (GO:0003341)2.56035974
81cilium organization (GO:0044782)2.56024610
82negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55919676
83regulation of DNA endoreduplication (GO:0032875)2.55157736
84regulation of gamma-delta T cell activation (GO:0046643)2.54865348
85regulation of protein polyubiquitination (GO:1902914)2.53605170
86peristalsis (GO:0030432)2.53568400
87positive regulation of oligodendrocyte differentiation (GO:0048714)2.53075369
88vascular endothelial growth factor signaling pathway (GO:0038084)2.51732112
89regulation of mesoderm development (GO:2000380)2.50025784
90atrial cardiac muscle cell action potential (GO:0086014)2.49592052
91histone H3-K9 methylation (GO:0051567)2.48985243
92cilium assembly (GO:0042384)2.48661404
93regulation of action potential (GO:0098900)2.48483832
94NLS-bearing protein import into nucleus (GO:0006607)2.48337585
95negative regulation of systemic arterial blood pressure (GO:0003085)2.47872032
96presynaptic membrane assembly (GO:0097105)2.47642031
97transmission of nerve impulse (GO:0019226)2.47603988
98cellular response to cholesterol (GO:0071397)2.46908148
99limb bud formation (GO:0060174)2.46867323
100reciprocal meiotic recombination (GO:0007131)2.46349091
101reciprocal DNA recombination (GO:0035825)2.46349091
102neuronal stem cell maintenance (GO:0097150)2.44957708
103cell differentiation in spinal cord (GO:0021515)2.44569156
104multicellular organism reproduction (GO:0032504)2.43718025
105growth hormone receptor signaling pathway (GO:0060396)2.43472876
106DNA deamination (GO:0045006)2.43424996
107negative regulation of vascular permeability (GO:0043116)2.43223985
108spinal cord development (GO:0021510)2.42824474
109germ cell migration (GO:0008354)2.42234309
110protein polyglutamylation (GO:0018095)2.42205965
111axoneme assembly (GO:0035082)2.42068905
112negative regulation of translation, ncRNA-mediated (GO:0040033)2.40377096
113regulation of translation, ncRNA-mediated (GO:0045974)2.40377096
114negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.40377096
115negative regulation of reactive oxygen species metabolic process (GO:2000378)2.39811973
116synaptic transmission, cholinergic (GO:0007271)2.39656076
117behavioral response to ethanol (GO:0048149)2.39376918
118photoreceptor cell development (GO:0042461)2.37031370
119forebrain neuron differentiation (GO:0021879)2.36602530
120negative regulation of oligodendrocyte differentiation (GO:0048715)2.36213111
121fucosylation (GO:0036065)2.35626421
122coronary vasculature morphogenesis (GO:0060977)2.31390048
123substrate-dependent cell migration (GO:0006929)2.31202563
124I-kappaB phosphorylation (GO:0007252)2.29913950
125establishment of nucleus localization (GO:0040023)2.29783552
126regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.23584563
127cortical actin cytoskeleton organization (GO:0030866)2.23115949
128positive thymic T cell selection (GO:0045059)2.21621830
129mannose metabolic process (GO:0006013)2.19565453
130positive regulation of antigen processing and presentation (GO:0002579)2.19395436
131heart morphogenesis (GO:0003007)2.17599840
132positive regulation of glycogen biosynthetic process (GO:0045725)2.15942071
133T cell selection (GO:0045058)2.15078667
134cell proliferation involved in metanephros development (GO:0072203)2.14441216
135mitotic sister chromatid cohesion (GO:0007064)2.14276318
136morphogenesis of an endothelium (GO:0003159)2.13106215
137endothelial tube morphogenesis (GO:0061154)2.13106215
138retrograde transport, vesicle recycling within Golgi (GO:0000301)2.12815259
139peptidyl-tyrosine autophosphorylation (GO:0038083)2.12687625
140activated T cell proliferation (GO:0050798)2.11375559
141cellular response to growth hormone stimulus (GO:0071378)2.10220755
142neuron projection extension involved in neuron projection guidance (GO:1902284)2.09921884
143axon extension involved in axon guidance (GO:0048846)2.09921884
144positive T cell selection (GO:0043368)2.09816338
145thymic T cell selection (GO:0045061)2.09747042
146nucleus localization (GO:0051647)2.07926857
147sodium ion export (GO:0071436)2.07859290
148positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.07092014
149L-amino acid import (GO:0043092)2.06840709
150face morphogenesis (GO:0060325)2.06763278
151positive regulation by symbiont of host defense response (GO:0052509)2.06706306
152modulation by symbiont of host defense response (GO:0052031)2.06706306
153modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.06706306
154modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.06706306
155positive regulation by organism of defense response of other organism involved in symbiotic interact2.06706306
156modulation by symbiont of host immune response (GO:0052553)2.06706306
157establishment of protein localization to Golgi (GO:0072600)2.04953419
158locomotory exploration behavior (GO:0035641)2.03481888
159leukocyte aggregation (GO:0070486)2.03138333
160glial cell proliferation (GO:0014009)2.02689765
161embryonic camera-type eye morphogenesis (GO:0048596)2.02261734
162amino acid import (GO:0043090)2.02234787
163natural killer cell differentiation (GO:0001779)2.00282908
164cellular response to vascular endothelial growth factor stimulus (GO:0035924)1.99493258
165protein targeting to Golgi (GO:0000042)1.99065785
166regulation of B cell receptor signaling pathway (GO:0050855)1.97493081
167clathrin coat assembly (GO:0048268)1.96202694
168peptidyl-lysine trimethylation (GO:0018023)1.94690175
169regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.93854563
170positive regulation of macrophage cytokine production (GO:0060907)1.93356867
171regulation of tolerance induction (GO:0002643)1.92813921
172negative regulation of amyloid precursor protein catabolic process (GO:1902992)1.92709423
173positive regulation of natural killer cell differentiation (GO:0032825)1.90110854
174regulation of NFAT protein import into nucleus (GO:0051532)1.89123916
175histone H3-K4 methylation (GO:0051568)1.88698219
176positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.86894242
177establishment of endothelial barrier (GO:0061028)1.84858655
178regulation of axon extension involved in axon guidance (GO:0048841)1.84743187
179regulation of histone deacetylation (GO:0031063)1.84412813
180nerve growth factor signaling pathway (GO:0038180)1.84212875
181tyrosine phosphorylation of STAT protein (GO:0007260)1.83042716
182patterning of blood vessels (GO:0001569)1.82846445
183regulation of regulatory T cell differentiation (GO:0045589)1.82351191
184cortical cytoskeleton organization (GO:0030865)1.82077379
185radial glial cell differentiation (GO:0060019)1.81640074
186regulation of ARF protein signal transduction (GO:0032012)1.81583675
187monocyte differentiation (GO:0030224)1.81539907
188pre-miRNA processing (GO:0031054)1.80551502
189histone lysine demethylation (GO:0070076)1.80328243
190hippo signaling (GO:0035329)1.80229662
191JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)1.79993326
192cell adhesion mediated by integrin (GO:0033627)1.79619011
193positive regulation of Rap GTPase activity (GO:0032854)1.78912959

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.11813601
2EZH2_22144423_ChIP-Seq_EOC_Human4.37632758
3ZNF274_21170338_ChIP-Seq_K562_Hela3.65433252
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57959504
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.21230635
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78909083
7VDR_22108803_ChIP-Seq_LS180_Human2.74989756
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52514330
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.47712740
10RUNX_20019798_ChIP-Seq_JUKART_Human2.43739159
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.38655339
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18749041
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13529742
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.13145647
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12729010
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05607273
17IGF1R_20145208_ChIP-Seq_DFB_Human2.04977166
18FUS_26573619_Chip-Seq_HEK293_Human2.03680722
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03380763
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01753174
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.99925309
22EWS_26573619_Chip-Seq_HEK293_Human1.94743681
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92547795
24P300_19829295_ChIP-Seq_ESCs_Human1.91017455
25TAF15_26573619_Chip-Seq_HEK293_Human1.84430351
26FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84200635
27ER_23166858_ChIP-Seq_MCF-7_Human1.78790922
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.78139571
29* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78039006
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77635311
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.68104954
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68092998
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67555899
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66507098
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65628100
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.64936130
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.60207989
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.57902809
39TCF4_23295773_ChIP-Seq_U87_Human1.57551779
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56827966
41DROSHA_22980978_ChIP-Seq_HELA_Human1.56742561
42DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55915991
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54018889
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52333134
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52229550
46* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51062000
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50964217
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50660160
49IRF1_19129219_ChIP-ChIP_H3396_Human1.50321372
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.49351047
51BCAT_22108803_ChIP-Seq_LS180_Human1.49347663
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.48529127
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48134282
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45764910
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45505912
56REST_21632747_ChIP-Seq_MESCs_Mouse1.45206349
57KDM2B_26808549_Chip-Seq_DND41_Human1.44131528
58CBP_20019798_ChIP-Seq_JUKART_Human1.43657430
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43657430
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.43424337
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.42071798
62TCF7_22412390_ChIP-Seq_EML_Mouse1.41276165
63AR_25329375_ChIP-Seq_VCAP_Human1.40648971
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39824366
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38974112
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.38554497
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38320012
68VDR_24787735_ChIP-Seq_THP-1_Human1.38231613
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35037385
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33350738
71TP53_16413492_ChIP-PET_HCT116_Human1.32831631
72SPI1_23127762_ChIP-Seq_K562_Human1.31651763
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31378681
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29543030
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28746032
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28700412
77MYC_22102868_ChIP-Seq_BL_Human1.28302732
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.27618301
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26744043
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.26564816
81RXR_22108803_ChIP-Seq_LS180_Human1.26563874
82* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26402001
83RUNX2_22187159_ChIP-Seq_PCA_Human1.26211020
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25113227
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23697936
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22779031
87ESR1_20079471_ChIP-ChIP_T-47D_Human1.22133252
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.21630729
89TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21399562
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.20441822
91CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20220286
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19151945
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18781877
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.18445660
95CLOCK_20551151_ChIP-Seq_293T_Human1.18132877
96RNF2_27304074_Chip-Seq_NSC_Mouse1.17997221
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17772949
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17699894
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.17630931
100TCF4_22108803_ChIP-Seq_LS180_Human1.16690695
101TP53_22573176_ChIP-Seq_HFKS_Human1.16674911
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.16505686
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16407283
104EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16237002
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.15949987
106AR_21572438_ChIP-Seq_LNCaP_Human1.15408580
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15017212
108MYB_26560356_Chip-Seq_TH2_Human1.14681132
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.13951641
110FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13601453
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13191142
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12192664
113EZH2_27304074_Chip-Seq_ESCs_Mouse1.12035014
114* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11794286
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11754526
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11397613
117MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11312953
118BRD4_25478319_ChIP-Seq_HGPS_Human1.11047710
119FOXO3_23340844_ChIP-Seq_DLD1_Human1.10768766
120* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10654716
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10402242
122* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10262882
123JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08940162
124KDM2B_26808549_Chip-Seq_REH_Human1.08286953
125KDM2B_26808549_Chip-Seq_K562_Human1.08282232
126SOX2_21211035_ChIP-Seq_LN229_Gbm1.08131265
127AHR_22903824_ChIP-Seq_MCF-7_Human1.06803155
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06750389
129WT1_19549856_ChIP-ChIP_CCG9911_Human1.06686220
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.06387105
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05544459
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05005870
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03560821
134TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03503153
135MAF_26560356_Chip-Seq_TH1_Human1.03388371
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03212180
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01006375
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00998108
139ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00880707
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00695693
141IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00554740
142NANOG_19829295_ChIP-Seq_ESCs_Human1.00405959
143SOX2_19829295_ChIP-Seq_ESCs_Human1.00405959
144GBX2_23144817_ChIP-Seq_PC3_Human1.00279820
145ISL1_27105846_Chip-Seq_CPCs_Mouse1.00200895
146SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99922813
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99523247
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99065513
149KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98625151
150POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97853275
151P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96594209
152GATA3_21878914_ChIP-Seq_MCF-7_Human0.96458803
153GATA3_27048872_Chip-Seq_THYMUS_Human0.95486173
154IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95473218
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.95294684
156TBX20_22080862_ChIP-Seq_HEART_Mouse0.95294684
157CJUN_26792858_Chip-Seq_BT549_Human0.94481176
158IRF8_21731497_ChIP-ChIP_J774_Mouse0.94391551
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94163615
160SMAD4_21799915_ChIP-Seq_A2780_Human0.93401723
161NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93379977
162UTX_26944678_Chip-Seq_JUKART_Human0.92985743
163HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92320989
164MYB_26560356_Chip-Seq_TH1_Human0.91239095
165AR_19668381_ChIP-Seq_PC3_Human0.91041500
166GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90159091
167SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90023395
168YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89632634
169GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88917107
170EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88177557
171RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88177557
172SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87005884
173VDR_24763502_ChIP-Seq_THP-1_Human0.86955857
174MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86507720
175TCF4_18268006_ChIP-ChIP_LS174T_Human0.86359827
176POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86184219
177TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86184219
178STAT3_23295773_ChIP-Seq_U87_Human0.86053274
179PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85351631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.06551141
2MP0003300_gastrointestinal_ulcer3.33182722
3MP0009278_abnormal_bone_marrow2.98086991
4MP0003136_yellow_coat_color2.90846372
5MP0003646_muscle_fatigue2.85807178
6MP0003045_fibrosis2.66771147
7MP0003787_abnormal_imprinting2.34468660
8MP0003195_calcinosis2.33479482
9MP0002102_abnormal_ear_morphology2.26577327
10MP0005076_abnormal_cell_differentiation2.24417858
11MP0001879_abnormal_lymphatic_vessel2.18194960
12MP0008877_abnormal_DNA_methylation2.16958382
13MP0003091_abnormal_cell_migration2.07252721
14MP0003705_abnormal_hypodermis_morpholog2.04870938
15MP0006292_abnormal_olfactory_placode2.04261063
16MP0000733_abnormal_muscle_development1.95969071
17MP0004142_abnormal_muscle_tone1.94673644
18MP0003950_abnormal_plasma_membrane1.90092124
19MP0008961_abnormal_basal_metabolism1.89225833
20MP0002837_dystrophic_cardiac_calcinosis1.86979598
21MP0002938_white_spotting1.86427775
22MP0001986_abnormal_taste_sensitivity1.85883604
23MP0002166_altered_tumor_susceptibility1.85241378
24MP0001968_abnormal_touch/_nociception1.81312571
25MP0004133_heterotaxia1.80239821
26MP0002638_abnormal_pupillary_reflex1.78771007
27MP0001299_abnormal_eye_distance/1.77895714
28MP0009046_muscle_twitch1.77729174
29MP0000427_abnormal_hair_cycle1.76808932
30MP0004043_abnormal_pH_regulation1.73579467
31MP0004885_abnormal_endolymph1.73474107
32MP0000631_abnormal_neuroendocrine_gland1.72313412
33MP0000778_abnormal_nervous_system1.71714012
34MP0002653_abnormal_ependyma_morphology1.70504878
35MP0005174_abnormal_tail_pigmentation1.68624455
36MP0003279_aneurysm1.67835287
37MP0004272_abnormal_basement_membrane1.67656119
38MP0003890_abnormal_embryonic-extraembry1.67618412
39MP0005646_abnormal_pituitary_gland1.67491520
40MP0009745_abnormal_behavioral_response1.67243904
41MP0005645_abnormal_hypothalamus_physiol1.66231062
42MP0003303_peritoneal_inflammation1.65991781
43MP0002735_abnormal_chemical_nociception1.65403131
44MP0005387_immune_system_phenotype1.65185114
45MP0001790_abnormal_immune_system1.65185114
46MP0001835_abnormal_antigen_presentation1.57181008
47MP0003121_genomic_imprinting1.54599420
48MP0004510_myositis1.54016740
49MP0010352_gastrointestinal_tract_polyps1.53454286
50MP0008438_abnormal_cutaneous_collagen1.50723154
51MP0004808_abnormal_hematopoietic_stem1.50527292
52MP0002272_abnormal_nervous_system1.49258444
53MP0001486_abnormal_startle_reflex1.48349254
54MP0005253_abnormal_eye_physiology1.48077719
55MP0001984_abnormal_olfaction1.47560727
56MP0003828_pulmonary_edema1.45721055
57MP0006072_abnormal_retinal_apoptosis1.44084971
58MP0004145_abnormal_muscle_electrophysio1.43331931
59MP0003122_maternal_imprinting1.43173588
60MP0001485_abnormal_pinna_reflex1.43092348
61MP0008872_abnormal_physiological_respon1.41429908
62MP0002877_abnormal_melanocyte_morpholog1.41185445
63MP0002006_tumorigenesis1.40043126
64MP0000685_abnormal_immune_system1.38475676
65MP0000383_abnormal_hair_follicle1.38293091
66MP0009384_cardiac_valve_regurgitation1.37851493
67MP0002163_abnormal_gland_morphology1.37228161
68MP0008057_abnormal_DNA_replication1.34697311
69MP0000372_irregular_coat_pigmentation1.33861443
70MP0004924_abnormal_behavior1.32668492
71MP0005386_behavior/neurological_phenoty1.32668492
72MP0003172_abnormal_lysosome_physiology1.32437064
73MP0002736_abnormal_nociception_after1.31184000
74MP0005623_abnormal_meninges_morphology1.30969485
75MP0000767_abnormal_smooth_muscle1.29559494
76MP0000003_abnormal_adipose_tissue1.28266824
77MP0004742_abnormal_vestibular_system1.28156814
78MP0002572_abnormal_emotion/affect_behav1.25607590
79MP0001873_stomach_inflammation1.25263640
80MP0006276_abnormal_autonomic_nervous1.25091779
81MP0001958_emphysema1.25055097
82MP0003183_abnormal_peptide_metabolism1.23869749
83MP0005670_abnormal_white_adipose1.23822661
84MP0005671_abnormal_response_to1.23240753
85MP0002067_abnormal_sensory_capabilities1.20749521
86MP0003763_abnormal_thymus_physiology1.20400931
87MP0001501_abnormal_sleep_pattern1.20294125
88MP0000428_abnormal_craniofacial_morphol1.19449951
89MP0001800_abnormal_humoral_immune1.19437288
90MP0002876_abnormal_thyroid_physiology1.19142892
91MP0002925_abnormal_cardiovascular_devel1.18909556
92MP0002557_abnormal_social/conspecific_i1.18108106
93MP0003943_abnormal_hepatobiliary_system1.16964159
94MP0002064_seizures1.15173259
95MP0005195_abnormal_posterior_eye1.14599281
96MP0002452_abnormal_antigen_presenting1.12779654
97MP0004130_abnormal_muscle_cell1.12507506
98MP0002095_abnormal_skin_pigmentation1.11210403
99MP0001502_abnormal_circadian_rhythm1.10142681
100MP0001545_abnormal_hematopoietic_system1.09698023
101MP0005397_hematopoietic_system_phenotyp1.09698023
102MP0002063_abnormal_learning/memory/cond1.09575756
103MP0000013_abnormal_adipose_tissue1.08423492
104MP0010630_abnormal_cardiac_muscle1.08331362
105MP0002752_abnormal_somatic_nervous1.07648373
106MP0003690_abnormal_glial_cell1.07247811
107MP0003878_abnormal_ear_physiology1.06622950
108MP0005377_hearing/vestibular/ear_phenot1.06622950
109MP0001293_anophthalmia1.06155920
110MP0000026_abnormal_inner_ear1.05159746
111MP0005167_abnormal_blood-brain_barrier1.04666093
112MP0001324_abnormal_eye_pigmentation1.04165292
113MP0003385_abnormal_body_wall1.02645441
114MP0003880_abnormal_central_pattern1.02484320
115MP0005257_abnormal_intraocular_pressure1.01844094
116MP0004215_abnormal_myocardial_fiber1.01054817
117MP0003635_abnormal_synaptic_transmissio1.00901802
118MP0002168_other_aberrant_phenotype1.00825449
119MP0005171_absent_coat_pigmentation1.00760175
120MP0003937_abnormal_limbs/digits/tail_de1.00015053
121MP0004147_increased_porphyrin_level0.98776471
122MP0002234_abnormal_pharynx_morphology0.98059452
123MP0002160_abnormal_reproductive_system0.97149830
124MP0001819_abnormal_immune_cell0.96425529
125MP0002420_abnormal_adaptive_immunity0.95614976
126MP0005389_reproductive_system_phenotype0.94881164
127MP0001970_abnormal_pain_threshold0.94417193
128MP0002998_abnormal_bone_remodeling0.94089037
129MP0002108_abnormal_muscle_morphology0.93803946
130MP0002009_preneoplasia0.91675656
131MP0003566_abnormal_cell_adhesion0.91275796
132MP0005375_adipose_tissue_phenotype0.90806746
133MP0000566_synostosis0.90763161
134MP0004084_abnormal_cardiac_muscle0.90674387
135MP0010307_abnormal_tumor_latency0.89972706
136MP0002751_abnormal_autonomic_nervous0.89791982
137MP0002184_abnormal_innervation0.89149020
138MP0002398_abnormal_bone_marrow0.88809800
139MP0000955_abnormal_spinal_cord0.88195895
140MP0002128_abnormal_blood_circulation0.87826039
141MP0002723_abnormal_immune_serum0.87533109
142MP0003137_abnormal_impulse_conducting0.87155738
143MP0005423_abnormal_somatic_nervous0.87014757
144MP0002733_abnormal_thermal_nociception0.86645783
145MP0002928_abnormal_bile_duct0.86140555
146MP0003448_altered_tumor_morphology0.83789590
147MP0002882_abnormal_neuron_morphology0.83030938
148MP0000371_diluted_coat_color0.82750497
149MP0001919_abnormal_reproductive_system0.82728417
150MP0005391_vision/eye_phenotype0.82403050
151MP0002089_abnormal_postnatal_growth/wei0.82272497
152MP0004858_abnormal_nervous_system0.81951577
153MP0005503_abnormal_tendon_morphology0.81738776
154MP0000266_abnormal_heart_morphology0.81622262
155MP0000703_abnormal_thymus_morphology0.81447685
156MP0005000_abnormal_immune_tolerance0.81380670
157MP0001853_heart_inflammation0.80750895
158MP0001529_abnormal_vocalization0.80068860
159MP0005248_abnormal_Harderian_gland0.79131843
160MP0004087_abnormal_muscle_fiber0.78987983
161MP0009780_abnormal_chondrocyte_physiolo0.78831401
162MP0009703_decreased_birth_body0.78823853
163MP0000647_abnormal_sebaceous_gland0.78686396
164MP0002405_respiratory_system_inflammati0.78633993
165MP0002933_joint_inflammation0.78227633
166MP0001784_abnormal_fluid_regulation0.77658993
167MP0008875_abnormal_xenobiotic_pharmacok0.76990931
168MP0000230_abnormal_systemic_arterial0.76103906
169MP0003123_paternal_imprinting0.75015345
170MP0010368_abnormal_lymphatic_system0.74993257
171MP0001614_abnormal_blood_vessel0.74185262
172MP0005379_endocrine/exocrine_gland_phen0.74152380
173MP0002734_abnormal_mechanical_nocicepti0.73847815
174MP0000049_abnormal_middle_ear0.73618684
175MP0003119_abnormal_digestive_system0.72837829
176MP0006054_spinal_hemorrhage0.72058526
177MP0001963_abnormal_hearing_physiology0.71938905
178MP0000716_abnormal_immune_system0.71919229
179MP0003935_abnormal_craniofacial_develop0.71578434
180MP0003698_abnormal_male_reproductive0.71281236
181MP0005666_abnormal_adipose_tissue0.71224024
182MP0008775_abnormal_heart_ventricle0.70989858
183MP0008569_lethality_at_weaning0.70494466
184MP0001851_eye_inflammation0.69298595
185MP0000015_abnormal_ear_pigmentation0.67782473
186MP0005551_abnormal_eye_electrophysiolog0.67576600
187MP0001270_distended_abdomen0.66619006
188MP0004134_abnormal_chest_morphology0.66480654

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.37825346
2Abnormality of midbrain morphology (HP:0002418)4.10284054
3Molar tooth sign on MRI (HP:0002419)4.10284054
4Pancreatic fibrosis (HP:0100732)3.96499848
5Hyperventilation (HP:0002883)3.89060697
6Nephronophthisis (HP:0000090)3.87523180
7Genetic anticipation (HP:0003743)3.70179368
8True hermaphroditism (HP:0010459)3.62647506
9Abnormality of the renal medulla (HP:0100957)3.53103406
10Macroorchidism (HP:0000053)3.52112201
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.24958185
12Short 4th metacarpal (HP:0010044)3.24958185
13Protruding tongue (HP:0010808)3.21758969
14Abnormality of the renal cortex (HP:0011035)3.21405377
15Cerebral aneurysm (HP:0004944)3.20994252
16Abnormality of the fingertips (HP:0001211)3.19963157
17Chronic hepatic failure (HP:0100626)3.18444062
18Tubular atrophy (HP:0000092)3.15917616
19Progressive cerebellar ataxia (HP:0002073)3.05808467
20Hematochezia (HP:0002573)3.03104239
21Gaze-evoked nystagmus (HP:0000640)3.00166296
22Abnormality of the nasal septum (HP:0000419)2.92819972
23Type II lissencephaly (HP:0007260)2.90418373
24Birth length less than 3rd percentile (HP:0003561)2.87506946
25Patellar aplasia (HP:0006443)2.85904099
26Aortic aneurysm (HP:0004942)2.77687400
27Cystic liver disease (HP:0006706)2.72530970
28Oligodactyly (hands) (HP:0001180)2.71621705
29Attenuation of retinal blood vessels (HP:0007843)2.70924591
30Aplasia/Hypoplasia of the patella (HP:0006498)2.65193887
31Lissencephaly (HP:0001339)2.63301626
32Shallow orbits (HP:0000586)2.62660224
33Broad-based gait (HP:0002136)2.62481017
34Medial flaring of the eyebrow (HP:0010747)2.60031008
35Clumsiness (HP:0002312)2.55331544
36Inability to walk (HP:0002540)2.52480972
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.51425055
38Abnormality of the 4th metacarpal (HP:0010012)2.50791765
39Broad metatarsal (HP:0001783)2.47582195
40Trigonocephaly (HP:0000243)2.47296321
41Abnormal biliary tract physiology (HP:0012439)2.42535632
42Bile duct proliferation (HP:0001408)2.42535632
43Vertebral arch anomaly (HP:0008438)2.42409733
44Pendular nystagmus (HP:0012043)2.42383815
45Febrile seizures (HP:0002373)2.41559849
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41036437
47Abnormality of alanine metabolism (HP:0010916)2.41036437
48Hyperalaninemia (HP:0003348)2.41036437
49Narrow palate (HP:0000189)2.39499663
50Elfin facies (HP:0004428)2.38559034
51Cerebellar dysplasia (HP:0007033)2.38211831
52Absent speech (HP:0001344)2.38148293
53Congenital stationary night blindness (HP:0007642)2.31154760
54Hyperacusis (HP:0010780)2.30520578
55Chorioretinal atrophy (HP:0000533)2.30170529
56Fair hair (HP:0002286)2.28000594
57Arterial tortuosity (HP:0005116)2.27170049
58Abnormal drinking behavior (HP:0030082)2.21050997
59Polydipsia (HP:0001959)2.21050997
60Enlarged penis (HP:0000040)2.21050397
61Concave nail (HP:0001598)2.19854026
62Hypoplastic labia majora (HP:0000059)2.19660488
63Congenital hepatic fibrosis (HP:0002612)2.18869083
64Tented upper lip vermilion (HP:0010804)2.17996467
65Increased corneal curvature (HP:0100692)2.17992974
66Keratoconus (HP:0000563)2.17992974
67Anencephaly (HP:0002323)2.16476251
68Widely spaced teeth (HP:0000687)2.15592450
69Abnormality of the labia majora (HP:0012881)2.12771871
70Pachygyria (HP:0001302)2.11531878
71Aplasia/Hypoplasia of the tongue (HP:0010295)2.09636256
72Progressive inability to walk (HP:0002505)2.09406565
73Vascular tortuosity (HP:0004948)2.08781445
74Mitral valve prolapse (HP:0001634)2.08425659
75Stomach cancer (HP:0012126)2.07847591
76Dislocated radial head (HP:0003083)2.07376271
77Dilatation of the ascending aorta (HP:0005111)2.06246712
78Increased density of long bones (HP:0006392)2.05069782
79Absent frontal sinuses (HP:0002688)2.04481908
80Subacute progressive viral hepatitis (HP:0006572)2.02693044
81Aortic dissection (HP:0002647)2.00825959
82Sclerocornea (HP:0000647)2.00510017
83Ectopic kidney (HP:0000086)2.00461899
84Aqueductal stenosis (HP:0002410)2.00182444
85Gait imbalance (HP:0002141)1.99626188
86Focal motor seizures (HP:0011153)1.98841359
87Disproportionate tall stature (HP:0001519)1.98134998
88Furrowed tongue (HP:0000221)1.98098344
89Congenital sensorineural hearing impairment (HP:0008527)1.97893944
90Volvulus (HP:0002580)1.97613882
91Dynein arm defect of respiratory motile cilia (HP:0012255)1.95133407
92Absent/shortened dynein arms (HP:0200106)1.95133407
93Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.94076139
94Neoplasm of the heart (HP:0100544)1.93771367
95Optic nerve hypoplasia (HP:0000609)1.92695265
96Abolished electroretinogram (ERG) (HP:0000550)1.92503997
97Broad ribs (HP:0000885)1.91369471
98Aneurysm (HP:0002617)1.91304472
99Congenital primary aphakia (HP:0007707)1.90646728
100Abnormality of the radial head (HP:0003995)1.90270508
101Abnormal rod and cone electroretinograms (HP:0008323)1.89646433
102Dialeptic seizures (HP:0011146)1.89134225
103Pigmentary retinal degeneration (HP:0001146)1.88813073
104Postaxial foot polydactyly (HP:0001830)1.88222705
105Small hand (HP:0200055)1.87513767
106Congenital, generalized hypertrichosis (HP:0004540)1.87139022
107Hemiparesis (HP:0001269)1.85952852
108Nephrogenic diabetes insipidus (HP:0009806)1.85666012
109Focal seizures (HP:0007359)1.85552473
110Anophthalmia (HP:0000528)1.85251827
111Hypoplastic iliac wings (HP:0002866)1.85202228
112Bilateral microphthalmos (HP:0007633)1.85083124
113Long eyelashes (HP:0000527)1.84998101
114Renovascular hypertension (HP:0100817)1.84828509
115Mitral regurgitation (HP:0001653)1.84528187
116Genital tract atresia (HP:0001827)1.82770774
117Action tremor (HP:0002345)1.82455303
118Highly arched eyebrow (HP:0002553)1.81963395
119Truncal obesity (HP:0001956)1.81324047
120Hypoplastic nipples (HP:0002557)1.81279165
121Drooling (HP:0002307)1.80323466
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79625685
123Decreased electroretinogram (ERG) amplitude (HP:0000654)1.79213870
124Constricted visual fields (HP:0001133)1.78958726
125Decreased circulating renin level (HP:0003351)1.78857821
126Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78831319
127Hemiplegia (HP:0002301)1.77813829
128Dandy-Walker malformation (HP:0001305)1.77700777
129Renal cortical cysts (HP:0000803)1.76875306
130Bulbous nose (HP:0000414)1.75986942
131Vaginal atresia (HP:0000148)1.75940963
132Decreased central vision (HP:0007663)1.73911954
133Large for gestational age (HP:0001520)1.73425073
134Striae distensae (HP:0001065)1.73105756
135Fatigue (HP:0012378)1.72978467
136Generalized hypopigmentation of hair (HP:0011358)1.72880028
137Bicuspid aortic valve (HP:0001647)1.72689324
138Colitis (HP:0002583)1.72309783
139Intestinal atresia (HP:0011100)1.72118936
140Bladder diverticulum (HP:0000015)1.71411924
141Renal duplication (HP:0000075)1.71151594
142Spontaneous hematomas (HP:0007420)1.71003397
143Thick eyebrow (HP:0000574)1.70599755
144Broad thumb (HP:0011304)1.70479203
145Partial agenesis of the corpus callosum (HP:0001338)1.69799958
146Obsessive-compulsive behavior (HP:0000722)1.69781346
147Bowel diverticulosis (HP:0005222)1.69486303
148Flat cornea (HP:0007720)1.69090765
149Astigmatism (HP:0000483)1.68739743
150Spinal cord lesions (HP:0100561)1.68576329
151Syringomyelia (HP:0003396)1.68576329
152Labial hypoplasia (HP:0000066)1.68350361
153Hand muscle atrophy (HP:0009130)1.67714308
154Limited elbow extension (HP:0001377)1.66459411
155Arterial thrombosis (HP:0004420)1.65578435
156Pulmonary infiltrates (HP:0002113)1.64910344
157Retrobulbar optic neuritis (HP:0100654)1.63753904
158Optic neuritis (HP:0100653)1.63753904
159Persistence of primary teeth (HP:0006335)1.63150175
160Chest pain (HP:0100749)1.61721060
161Difficulty running (HP:0009046)1.58176878
162Cutis marmorata (HP:0000965)1.57282801
163Depressed nasal tip (HP:0000437)1.57007350
164Midline defect of the nose (HP:0004122)1.55057514
165Spondylolisthesis (HP:0003302)1.54478942
166Broad phalanges of the hand (HP:0009768)1.54302224
167Heterotopia (HP:0002282)1.53966405
168Bony spicule pigmentary retinopathy (HP:0007737)1.53856910
169Transitional cell carcinoma of the bladder (HP:0006740)1.53659230
170Broad phalanx (HP:0006009)1.53309547
171Broad finger (HP:0001500)1.53251411
172T lymphocytopenia (HP:0005403)1.51961849
173Papillary thyroid carcinoma (HP:0002895)1.51389141
174Scapular winging (HP:0003691)1.51285407
175Broad long bones (HP:0005622)1.51000685
176Distal upper limb amyotrophy (HP:0007149)1.49956765
177Upper limb amyotrophy (HP:0009129)1.49956765
178Recurrent viral infections (HP:0004429)1.49575651
179Orchitis (HP:0100796)1.49326603
180Increased nuchal translucency (HP:0010880)1.49143175
181Joint laxity (HP:0001388)1.49107329
182Deep philtrum (HP:0002002)1.48194173
183Hypoplastic ischia (HP:0003175)1.47665263
184Hypoplasia of the maxilla (HP:0000327)1.47521477
185Pointed chin (HP:0000307)1.47446662
186Increased cerebral lipofuscin (HP:0011813)1.47017564
1872-3 toe syndactyly (HP:0004691)1.46376128
188Abnormality of T cell number (HP:0011839)1.42704807
189Mediastinal lymphadenopathy (HP:0100721)1.42100889
190Abnormality of the distal phalanx of the thumb (HP:0009617)1.41695090
191Adactyly (HP:0009776)1.41600981
192Chronic otitis media (HP:0000389)1.40969585
193Increased CSF protein (HP:0002922)1.40250540
194Camptodactyly of toe (HP:0001836)1.40201459
195Autoimmune thrombocytopenia (HP:0001973)1.39781518
196Skull defect (HP:0001362)1.38687991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B3.14005085
2ACVR1B3.04145543
3ADRBK22.75747130
4CAMK1G2.45984281
5PNCK2.40532433
6TLK12.40180369
7WNK32.36484170
8CAMK1D2.34874244
9INSRR2.28492542
10CASK2.24740145
11TRIB32.24179542
12WNK42.23330701
13RIPK12.22574580
14CDK122.21513491
15JAK12.20760614
16EPHA32.10908417
17ZAK2.00633577
18PTK61.98810020
19MARK11.97334000
20FGFR31.92874413
21TTN1.89590944
22NLK1.89059239
23TAOK31.84938190
24PDGFRA1.82363360
25SIK11.81641422
26TYK21.77998306
27MAPK131.77524636
28MAP3K41.69058349
29JAK31.66065789
30MAP4K21.65399622
31SIK21.64549343
32PINK11.62997184
33MAP4K11.61184706
34TGFBR21.55957562
35TIE11.55581393
36PDGFRB1.53792787
37MAP3K141.50996492
38PKN21.50947186
39TXK1.50596346
40PIK3CA1.48110111
41ITK1.45139255
42FGFR41.45010559
43SGK31.42499784
44BRD41.40432629
45NTRK31.40183398
46MAP3K131.35250257
47FGFR21.33876489
48PRKCH1.33084312
49STK391.30914660
50EPHB11.27352909
51MKNK21.26823375
52NTRK21.22660250
53ADRBK11.22432775
54SGK21.17136872
55STK101.16876632
56LATS11.16411386
57WNK11.14549177
58MAP3K101.14113427
59ICK1.14059761
60MAP2K61.13364527
61CHUK1.12941829
62DMPK1.12331381
63AKT31.10796992
64PAK31.09271958
65TYRO31.06916914
66OXSR11.04982647
67DYRK21.04393500
68MELK1.03808485
69EEF2K1.00221147
70RET0.96272701
71MAP2K70.95984400
72CDK60.95365269
73HCK0.92106400
74CSK0.90665890
75MAP3K70.90300020
76DAPK20.89175945
77LRRK20.88621026
78MAPK150.88535115
79TEC0.88367125
80MTOR0.88085734
81OBSCN0.87962141
82BRSK20.87716064
83ZAP700.87691074
84SGK4940.86754065
85SGK2230.86754065
86TNIK0.86681614
87BMX0.85592442
88NEK20.81119794
89PRKCG0.80976672
90FGFR10.80839609
91PRPF4B0.80492409
92CDK90.80386310
93FRK0.79982753
94INSR0.77067345
95PKN10.76627986
96CAMK10.76070141
97JAK20.73429912
98STK110.71364844
99MARK20.71042280
100PRKCE0.70272201
101LCK0.69970174
102WEE10.68361039
103IKBKE0.68018317
104MARK30.67718074
105CDC42BPA0.67473254
106ALK0.66643360
107TBK10.66367026
108STK38L0.66240020
109SGK10.65881657
110CSF1R0.64737986
111IGF1R0.64697950
112BCR0.63866089
113PIK3CG0.61941455
114CAMK40.61586065
115KDR0.61538143
116GRK10.61266710
117PRKCQ0.61200538
118SCYL20.60978634
119MAPK70.60098855
120CSNK1A1L0.59094544
121ERN10.58391801
122HIPK20.58314754
123ERBB30.57311564
124PTK20.56215655
125LMTK20.55573137
126IRAK10.55125859
127CAMKK10.53686429
128KIT0.53410790
129DDR20.53161587
130SRC0.52950973
131NUAK10.51648344
132TGFBR10.51216580
133IKBKB0.50525255
134CAMKK20.49630460
135EGFR0.49102727
136PRKD30.48855146
137CSNK1G20.48591563
138FYN0.48570352
139MAP2K40.46830158
140PRKAA10.46312301
141PTK2B0.46091772
142RPS6KA50.45776328
143RPS6KA60.44758606
144TNK20.44668357
145DYRK1A0.44668330
146CAMK2A0.44526784
147PRKG10.43416572
148CDK30.43363415
149PRKAA20.42195629
150MAPK80.42090752
151NEK90.41701794
152ROCK10.39455636
153CSNK1G10.38671644
154CSNK1D0.38600040
155ERBB20.38287695
156FES0.37629244
157PRKACA0.37479138
158STK30.37118476
159CSNK1A10.34961487
160VRK10.33257780
161PRKCZ0.32517232
162MKNK10.31705682
163ATM0.30107070
164TRIM280.29723650

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.74843942
2Linoleic acid metabolism_Homo sapiens_hsa005912.51222970
3Nitrogen metabolism_Homo sapiens_hsa009102.50012488
4Nicotine addiction_Homo sapiens_hsa050332.47723535
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.21871194
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.11740226
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.06207505
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98718030
9Butanoate metabolism_Homo sapiens_hsa006501.96764357
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.95813589
11Taste transduction_Homo sapiens_hsa047421.88491305
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75913146
13Selenocompound metabolism_Homo sapiens_hsa004501.74320438
14Basal transcription factors_Homo sapiens_hsa030221.73510072
15Ether lipid metabolism_Homo sapiens_hsa005651.69781323
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61737662
17Fanconi anemia pathway_Homo sapiens_hsa034601.52343482
18ABC transporters_Homo sapiens_hsa020101.50200625
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.45444174
20Caffeine metabolism_Homo sapiens_hsa002321.43506202
21Chronic myeloid leukemia_Homo sapiens_hsa052201.41410220
22Homologous recombination_Homo sapiens_hsa034401.39036618
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37952627
24Adherens junction_Homo sapiens_hsa045201.34213532
25Tryptophan metabolism_Homo sapiens_hsa003801.33828071
26T cell receptor signaling pathway_Homo sapiens_hsa046601.32343740
27GABAergic synapse_Homo sapiens_hsa047271.31455813
28Osteoclast differentiation_Homo sapiens_hsa043801.31176270
29Viral myocarditis_Homo sapiens_hsa054161.30715000
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28225216
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.27290820
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26630550
33Type II diabetes mellitus_Homo sapiens_hsa049301.26290738
34B cell receptor signaling pathway_Homo sapiens_hsa046621.24853805
35Toxoplasmosis_Homo sapiens_hsa051451.23562801
36Measles_Homo sapiens_hsa051621.21546794
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.21328756
38Circadian rhythm_Homo sapiens_hsa047101.21296521
39Dorso-ventral axis formation_Homo sapiens_hsa043201.20171134
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18735294
41RNA polymerase_Homo sapiens_hsa030201.17890766
42Proteoglycans in cancer_Homo sapiens_hsa052051.15334053
43Focal adhesion_Homo sapiens_hsa045101.15130469
44Dilated cardiomyopathy_Homo sapiens_hsa054141.14056705
45Ovarian steroidogenesis_Homo sapiens_hsa049131.12271890
46Serotonergic synapse_Homo sapiens_hsa047261.12055210
47Calcium signaling pathway_Homo sapiens_hsa040201.12039241
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10989312
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.10873868
50Graft-versus-host disease_Homo sapiens_hsa053321.10719954
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10300272
52Small cell lung cancer_Homo sapiens_hsa052221.09527895
53Chemokine signaling pathway_Homo sapiens_hsa040621.08704534
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08000219
55Leishmaniasis_Homo sapiens_hsa051401.07103441
56MicroRNAs in cancer_Homo sapiens_hsa052061.06691936
57Pancreatic cancer_Homo sapiens_hsa052121.06548553
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05773786
59Colorectal cancer_Homo sapiens_hsa052101.05162032
60mTOR signaling pathway_Homo sapiens_hsa041501.04906909
61Phototransduction_Homo sapiens_hsa047441.04775488
62Leukocyte transendothelial migration_Homo sapiens_hsa046701.04711040
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02738467
64Notch signaling pathway_Homo sapiens_hsa043301.02434355
65Endometrial cancer_Homo sapiens_hsa052131.02331524
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01126446
67Glioma_Homo sapiens_hsa052141.01065047
68Platelet activation_Homo sapiens_hsa046111.00868669
69RNA degradation_Homo sapiens_hsa030181.00169793
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99988179
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.99285586
72TNF signaling pathway_Homo sapiens_hsa046680.98515589
73Basal cell carcinoma_Homo sapiens_hsa052170.98411541
74Renal cell carcinoma_Homo sapiens_hsa052110.97760967
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97749711
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.96801862
77Primary immunodeficiency_Homo sapiens_hsa053400.96146278
78Olfactory transduction_Homo sapiens_hsa047400.94404778
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94277947
80Insulin resistance_Homo sapiens_hsa049310.94275612
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93870991
82Insulin secretion_Homo sapiens_hsa049110.93140253
83Hedgehog signaling pathway_Homo sapiens_hsa043400.91842967
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91815456
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91772167
86Estrogen signaling pathway_Homo sapiens_hsa049150.91349343
87Renin secretion_Homo sapiens_hsa049240.90877042
88Hepatitis B_Homo sapiens_hsa051610.90497763
89Prostate cancer_Homo sapiens_hsa052150.89809296
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89134877
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.88871484
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88211362
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87708508
94Acute myeloid leukemia_Homo sapiens_hsa052210.87384463
95Cholinergic synapse_Homo sapiens_hsa047250.86869667
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.86673384
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85709995
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85289119
99ECM-receptor interaction_Homo sapiens_hsa045120.83970996
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83297561
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83048200
102Influenza A_Homo sapiens_hsa051640.83031010
103Non-small cell lung cancer_Homo sapiens_hsa052230.82089817
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81636253
105Circadian entrainment_Homo sapiens_hsa047130.81636134
106Axon guidance_Homo sapiens_hsa043600.80654260
107Dopaminergic synapse_Homo sapiens_hsa047280.79947645
108Lysine degradation_Homo sapiens_hsa003100.79849990
109HTLV-I infection_Homo sapiens_hsa051660.79626578
110Prolactin signaling pathway_Homo sapiens_hsa049170.79256943
111ErbB signaling pathway_Homo sapiens_hsa040120.79198876
112FoxO signaling pathway_Homo sapiens_hsa040680.78846767
113Amoebiasis_Homo sapiens_hsa051460.78591758
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78220490
115Oxytocin signaling pathway_Homo sapiens_hsa049210.78066722
116Rap1 signaling pathway_Homo sapiens_hsa040150.75971665
117Gastric acid secretion_Homo sapiens_hsa049710.75923426
118Apoptosis_Homo sapiens_hsa042100.74297111
119Morphine addiction_Homo sapiens_hsa050320.73694317
120cAMP signaling pathway_Homo sapiens_hsa040240.73535645
121Cardiac muscle contraction_Homo sapiens_hsa042600.73447741
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.73256845
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73241525
124MAPK signaling pathway_Homo sapiens_hsa040100.72358440
125Long-term potentiation_Homo sapiens_hsa047200.72301875
126Inositol phosphate metabolism_Homo sapiens_hsa005620.71962593
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71931030
128Glutamatergic synapse_Homo sapiens_hsa047240.71773572
129Allograft rejection_Homo sapiens_hsa053300.71627362
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71541390
131Choline metabolism in cancer_Homo sapiens_hsa052310.71487152
132Salivary secretion_Homo sapiens_hsa049700.70963240
133VEGF signaling pathway_Homo sapiens_hsa043700.70546167
134Long-term depression_Homo sapiens_hsa047300.69817982
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.69640065
136Shigellosis_Homo sapiens_hsa051310.69582931
137Hepatitis C_Homo sapiens_hsa051600.69520197
138HIF-1 signaling pathway_Homo sapiens_hsa040660.69430296
139GnRH signaling pathway_Homo sapiens_hsa049120.69095652
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68801529
141TGF-beta signaling pathway_Homo sapiens_hsa043500.68660871
142Tuberculosis_Homo sapiens_hsa051520.68541071
143Endocytosis_Homo sapiens_hsa041440.67928333
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67788543
145Glycerolipid metabolism_Homo sapiens_hsa005610.65627275
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65496729
147Regulation of autophagy_Homo sapiens_hsa041400.65262873
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64338275
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62965051
150Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60571061
151Cocaine addiction_Homo sapiens_hsa050300.58126235
152One carbon pool by folate_Homo sapiens_hsa006700.57977607
153Arachidonic acid metabolism_Homo sapiens_hsa005900.55536923
154Hippo signaling pathway_Homo sapiens_hsa043900.55492694
155Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53735441
156Asthma_Homo sapiens_hsa053100.53177275
157Ras signaling pathway_Homo sapiens_hsa040140.49033491
158Peroxisome_Homo sapiens_hsa041460.48407204
159Chemical carcinogenesis_Homo sapiens_hsa052040.47606550
160Oxidative phosphorylation_Homo sapiens_hsa001900.45214214
161Histidine metabolism_Homo sapiens_hsa003400.43130260
162Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40708599
163Retinol metabolism_Homo sapiens_hsa008300.38262427
164Autoimmune thyroid disease_Homo sapiens_hsa053200.37288040
165Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36426613
166Amphetamine addiction_Homo sapiens_hsa050310.36406816
167Fatty acid biosynthesis_Homo sapiens_hsa000610.33594968
168Propanoate metabolism_Homo sapiens_hsa006400.33224310

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