LRCH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.88165106
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.38773631
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.38773631
4antigen processing and presentation of endogenous antigen (GO:0019883)5.04234175
5regulation of gamma-delta T cell differentiation (GO:0045586)4.66377971
6negative regulation of cell killing (GO:0031342)4.52386808
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.52386808
8detection of other organism (GO:0098543)4.44154294
9detection of bacterium (GO:0016045)4.43858689
10regulation of gamma-delta T cell activation (GO:0046643)4.35673736
11macrophage activation involved in immune response (GO:0002281)4.29646641
12positive thymic T cell selection (GO:0045059)4.26850296
13positive regulation of B cell differentiation (GO:0045579)4.19793311
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.15706126
15regulation of B cell receptor signaling pathway (GO:0050855)4.11782973
16antigen processing and presentation via MHC class Ib (GO:0002475)3.91616753
17regulation of B cell differentiation (GO:0045577)3.86783916
18negative regulation of lymphocyte mediated immunity (GO:0002707)3.83273224
19leukocyte aggregation (GO:0070486)3.78421717
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.70724247
21immunoglobulin mediated immune response (GO:0016064)3.70127636
22B cell receptor signaling pathway (GO:0050853)3.68646090
23negative thymic T cell selection (GO:0045060)3.65734320
24negative T cell selection (GO:0043383)3.63274835
25detection of external biotic stimulus (GO:0098581)3.60980940
26regulation of mast cell degranulation (GO:0043304)3.57851588
27negative regulation of leukocyte mediated immunity (GO:0002704)3.52350477
28negative regulation of phagocytosis (GO:0050765)3.47870423
29negative regulation of T cell mediated immunity (GO:0002710)3.43085840
30regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.41302857
31NIK/NF-kappaB signaling (GO:0038061)3.39906408
32regulation of myeloid leukocyte mediated immunity (GO:0002886)3.33767881
33response to host immune response (GO:0052572)3.33448105
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.33448105
35germinal center formation (GO:0002467)3.32775446
36thymic T cell selection (GO:0045061)3.31995142
37regulation of leukocyte degranulation (GO:0043300)3.30478562
38Arp2/3 complex-mediated actin nucleation (GO:0034314)3.28334697
39regulation of mast cell activation involved in immune response (GO:0033006)3.26098495
40positive T cell selection (GO:0043368)3.21000729
41mannose metabolic process (GO:0006013)3.20139075
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19484812
43regulation of tolerance induction (GO:0002643)3.17825916
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.15988269
45response to host (GO:0075136)3.15988269
46response to host defenses (GO:0052200)3.15988269
47negative regulation of granulocyte differentiation (GO:0030853)3.14714509
48detection of biotic stimulus (GO:0009595)3.14693353
49regulation of interferon-beta biosynthetic process (GO:0045357)3.11785792
50T cell selection (GO:0045058)3.08853438
51tolerance induction (GO:0002507)3.06808944
52positive regulation by symbiont of host defense response (GO:0052509)3.04297102
53modulation by symbiont of host defense response (GO:0052031)3.04297102
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.04297102
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.04297102
56positive regulation by organism of defense response of other organism involved in symbiotic interact3.04297102
57modulation by symbiont of host immune response (GO:0052553)3.04297102
58detection of molecule of bacterial origin (GO:0032490)3.03788169
59regulation of T-helper 2 cell differentiation (GO:0045628)3.03224811
60B cell mediated immunity (GO:0019724)2.98279359
61response to muramyl dipeptide (GO:0032495)2.98164703
62positive regulation of antigen processing and presentation (GO:0002579)2.97760224
63regulation of interleukin-12 biosynthetic process (GO:0045075)2.96518906
64negative regulation of erythrocyte differentiation (GO:0045647)2.95342338
65macrophage activation (GO:0042116)2.93842582
66microglial cell activation (GO:0001774)2.93697095
67regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93269924
68activated T cell proliferation (GO:0050798)2.92044664
69T cell migration (GO:0072678)2.91645382
70negative regulation of interleukin-6 production (GO:0032715)2.90466202
71negative regulation of innate immune response (GO:0045824)2.89391491
72natural killer cell differentiation (GO:0001779)2.88849748
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88287099
74response to interleukin-15 (GO:0070672)2.87666407
75leukocyte degranulation (GO:0043299)2.85772753
76leukocyte migration involved in inflammatory response (GO:0002523)2.85709253
77positive regulation of mast cell activation (GO:0033005)2.83951815
78neutrophil activation involved in immune response (GO:0002283)2.83816768
79regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.81980494
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81762104
81regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81474105
82regulation of natural killer cell mediated immunity (GO:0002715)2.81474105
83regulation of granulocyte differentiation (GO:0030852)2.81353366
84regulation of mast cell activation (GO:0033003)2.80793221
85positive regulation of granulocyte differentiation (GO:0030854)2.80455863
86regulation of regulated secretory pathway (GO:1903305)2.79894748
87regulation of T cell mediated cytotoxicity (GO:0001914)2.79421455
88T cell homeostasis (GO:0043029)2.79210979
89leukocyte cell-cell adhesion (GO:0007159)2.78092082
90antigen receptor-mediated signaling pathway (GO:0050851)2.76093059
91negative regulation of cytokine production involved in immune response (GO:0002719)2.75475915
92neutrophil activation (GO:0042119)2.75155439
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72782835
94negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.72135201
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.71484000
96negative regulation of T-helper cell differentiation (GO:0045623)2.71484000
97cellular extravasation (GO:0045123)2.71149200
98interferon-gamma production (GO:0032609)2.68709893
99negative regulation of type 2 immune response (GO:0002829)2.68611765
100regulation of type I interferon-mediated signaling pathway (GO:0060338)2.66793239
101mature B cell differentiation (GO:0002335)2.66437962
102negative regulation of interleukin-12 production (GO:0032695)2.66124974
103lymphocyte homeostasis (GO:0002260)2.63786070
104positive regulation of isotype switching (GO:0045830)2.63331714
105regulation of necroptotic process (GO:0060544)2.62525830
106respiratory burst (GO:0045730)2.61239499
107cellular response to zinc ion (GO:0071294)2.60458455
108regulation of alpha-beta T cell proliferation (GO:0046640)2.58778061
109T cell receptor signaling pathway (GO:0050852)2.55547354
110response to peptidoglycan (GO:0032494)2.54837571
111regulation of erythrocyte differentiation (GO:0045646)2.54401297
112regulation of antigen processing and presentation (GO:0002577)2.54324124
113pinocytosis (GO:0006907)2.54126515
114myeloid dendritic cell activation (GO:0001773)2.53009276
115positive regulation of histone deacetylation (GO:0031065)2.52479025
116mast cell activation (GO:0045576)2.52430950
117positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.51178338
118regulation of response to interferon-gamma (GO:0060330)2.51122092
119actin nucleation (GO:0045010)2.50885299
120regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.49986226
121mature B cell differentiation involved in immune response (GO:0002313)2.49839161
122natural killer cell activation (GO:0030101)2.49340125
123ribosomal small subunit assembly (GO:0000028)2.48393221
124response to type I interferon (GO:0034340)2.47067697
125regulation of T cell receptor signaling pathway (GO:0050856)2.46041125
126JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.45736315
127positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.45621547
128positive regulation of lamellipodium assembly (GO:0010592)2.45533542
129megakaryocyte development (GO:0035855)2.45526596
130lymph node development (GO:0048535)2.44986008
131granulocyte activation (GO:0036230)2.44257180
132regulation of T cell tolerance induction (GO:0002664)2.43602921
133interferon-gamma-mediated signaling pathway (GO:0060333)2.43217516
134defense response to protozoan (GO:0042832)2.41938390
135positive regulation of protein deacetylation (GO:0090312)2.41337474
136T cell costimulation (GO:0031295)2.41218193
137cellular response to type I interferon (GO:0071357)2.40155467
138type I interferon signaling pathway (GO:0060337)2.40155467
139leukocyte homeostasis (GO:0001776)2.39914303
140response to protozoan (GO:0001562)2.38149467
141cellular response to interleukin-15 (GO:0071350)2.36386510
142lymphocyte costimulation (GO:0031294)2.35755622
143myeloid cell activation involved in immune response (GO:0002275)2.35529236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.39388203
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.48806775
3MYC_22102868_ChIP-Seq_BL_Human3.38768145
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.01593214
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.99987392
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.98847791
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.97265219
8* VDR_21846776_ChIP-Seq_THP-1_Human2.92219695
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.90601421
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.72133700
11SCL_19346495_ChIP-Seq_HPC-7_Human2.71473005
12* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.60616560
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.45826635
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39678369
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.36739126
16* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31976419
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30137211
18MAF_26560356_Chip-Seq_TH1_Human2.24076743
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.21288030
20MYB_26560356_Chip-Seq_TH2_Human2.18124644
21SPI1_23547873_ChIP-Seq_NB4_Human2.17173412
22* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15801874
23* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.14010184
24* TCF7_22412390_ChIP-Seq_EML_Mouse2.11497981
25* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10221980
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.09984752
27* UTX_26944678_Chip-Seq_JUKART_Human2.08275761
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03085703
29* VDR_24763502_ChIP-Seq_THP-1_Human2.00399875
30MYB_26560356_Chip-Seq_TH1_Human1.99340693
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97595529
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.96219632
33* RUNX1_22412390_ChIP-Seq_EML_Mouse1.95076251
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94904776
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92865608
36RUNX_20019798_ChIP-Seq_JUKART_Human1.92828380
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90213326
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89794294
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86986281
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86723876
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86152567
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84701950
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83435161
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78649992
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73044135
46CIITA_25753668_ChIP-Seq_RAJI_Human1.71169033
47* SPI1_23127762_ChIP-Seq_K562_Human1.70401818
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70026867
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.64849781
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64230735
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61685986
52MAF_26560356_Chip-Seq_TH2_Human1.55338715
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52720685
54* ELK3_25401928_ChIP-Seq_HUVEC_Human1.50325987
55* KDM2B_26808549_Chip-Seq_DND41_Human1.50025724
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46303197
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46019224
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.46012570
59* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45569088
60RACK7_27058665_Chip-Seq_MCF-7_Human1.44319583
61P68_20966046_ChIP-Seq_HELA_Human1.41227494
62GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40761731
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40118795
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39806818
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39611948
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38879531
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.37170434
68KDM2B_26808549_Chip-Seq_K562_Human1.34455529
69GATA1_19941826_ChIP-Seq_K562_Human1.34332583
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34331648
71GATA3_27048872_Chip-Seq_THYMUS_Human1.30041015
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29902692
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29877795
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29767048
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26814830
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22146865
77SMC4_20622854_ChIP-Seq_HELA_Human1.20296089
78* VDR_24787735_ChIP-Seq_THP-1_Human1.17715313
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16283769
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16262772
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15692136
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15082466
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.14329930
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14251758
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12979918
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11858719
87PU_27001747_Chip-Seq_BMDM_Mouse1.10431863
88FOXP3_21729870_ChIP-Seq_TREG_Human1.09825296
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09363522
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08405043
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06694300
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05634811
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05400018
94TFEB_21752829_ChIP-Seq_HELA_Human1.04378223
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04245224
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04178885
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04076325
98NCOR1_26117541_ChIP-Seq_K562_Human1.03931027
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03816590
100VDR_23849224_ChIP-Seq_CD4+_Human1.02620330
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02618426
102TET1_21451524_ChIP-Seq_MESCs_Mouse1.02001752
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01266319
104LXR_22292898_ChIP-Seq_THP-1_Human1.01195924
105NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01142056
106MYC_18555785_ChIP-Seq_MESCs_Mouse0.98877501
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96597364
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96123753
109* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96057785
110DROSHA_22980978_ChIP-Seq_HELA_Human0.95083043
111* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94955599
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94816158
113CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94339886
114* XRN2_22483619_ChIP-Seq_HELA_Human0.94025710
115BCL6_27268052_Chip-Seq_Bcells_Human0.93860994
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92562209
117E2F1_21310950_ChIP-Seq_MCF-7_Human0.92156494
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.91779567
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89306658
120* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.88556129
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85943392
122KDM5A_27292631_Chip-Seq_BREAST_Human0.85605303
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85301369
124SPI1_20517297_ChIP-Seq_HL60_Human0.83548933
125GABP_19822575_ChIP-Seq_HepG2_Human0.82942098
126BCOR_27268052_Chip-Seq_Bcells_Human0.80133877
127MYC_19079543_ChIP-ChIP_MESCs_Mouse0.80032763
128* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79842307
129CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79178888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.61552649
2MP0000685_abnormal_immune_system3.24397954
3MP0005671_abnormal_response_to2.88990738
4MP0003763_abnormal_thymus_physiology2.88581719
5MP0001800_abnormal_humoral_immune2.81872876
6MP0002396_abnormal_hematopoietic_system2.76422524
7MP0001790_abnormal_immune_system2.67532318
8MP0005387_immune_system_phenotype2.67532318
9MP0009278_abnormal_bone_marrow2.62216792
10MP0003436_decreased_susceptibility_to2.60836481
11MP0002452_abnormal_antigen_presenting2.50532437
12MP0002398_abnormal_bone_marrow2.42249203
13MP0002420_abnormal_adaptive_immunity2.41216308
14MP0005000_abnormal_immune_tolerance2.39769919
15MP0001819_abnormal_immune_cell2.39125156
16MP0002723_abnormal_immune_serum2.38994346
17MP0005025_abnormal_response_to2.28417647
18MP0009785_altered_susceptibility_to2.26910431
19MP0003303_peritoneal_inflammation2.24468985
20MP0002405_respiratory_system_inflammati2.20180554
21MP0002419_abnormal_innate_immunity2.19522572
22MP0004808_abnormal_hematopoietic_stem2.18254516
23MP0001545_abnormal_hematopoietic_system2.17746209
24MP0005397_hematopoietic_system_phenotyp2.17746209
25MP0000716_abnormal_immune_system2.14622841
26MP0002166_altered_tumor_susceptibility2.14564713
27MP0000689_abnormal_spleen_morphology2.12468767
28MP0005464_abnormal_platelet_physiology2.05784164
29MP0008260_abnormal_autophagy2.04146432
30MP0002722_abnormal_immune_system2.04060152
31MP0001873_stomach_inflammation2.01753634
32MP0009333_abnormal_splenocyte_physiolog1.99191557
33MP0005451_abnormal_body_composition1.94364926
34MP0003300_gastrointestinal_ulcer1.90413808
35MP0002429_abnormal_blood_cell1.87373007
36MP0000703_abnormal_thymus_morphology1.86530529
37MP0005058_abnormal_lysosome_morphology1.82143322
38MP0003693_abnormal_embryo_hatching1.80163639
39MP0002148_abnormal_hypersensitivity_rea1.79487756
40MP0006082_CNS_inflammation1.79403354
41MP0010155_abnormal_intestine_physiology1.78420215
42MP0000465_gastrointestinal_hemorrhage1.68413784
43MP0004381_abnormal_hair_follicle1.67048243
44MP0003172_abnormal_lysosome_physiology1.66531755
45MP0002006_tumorigenesis1.62283476
46MP0004947_skin_inflammation1.61507987
47MP0000490_abnormal_crypts_of1.59302868
48MP0001845_abnormal_inflammatory_respons1.55223932
49MP0001853_heart_inflammation1.51773945
50MP0003077_abnormal_cell_cycle1.46849318
51MP0005174_abnormal_tail_pigmentation1.46339447
52MP0004510_myositis1.43843120
53MP0003866_abnormal_defecation1.39467912
54MP0003183_abnormal_peptide_metabolism1.39355939
55MP0003191_abnormal_cellular_cholesterol1.38387360
56MP0008057_abnormal_DNA_replication1.38311907
57MP0000858_altered_metastatic_potential1.37369179
58MP0010094_abnormal_chromosome_stability1.28727627
59MP0005075_abnormal_melanosome_morpholog1.27465586
60MP0005310_abnormal_salivary_gland1.27101329
61MP0009840_abnormal_foam_cell1.26492892
62MP0002933_joint_inflammation1.25397099
63MP0010352_gastrointestinal_tract_polyps1.25051093
64MP0002019_abnormal_tumor_incidence1.22319529
65MP0001533_abnormal_skeleton_physiology1.21773467
66MP0003724_increased_susceptibility_to1.20180103
67MP0010307_abnormal_tumor_latency1.19640963
68MP0003111_abnormal_nucleus_morphology1.18508998
69MP0008007_abnormal_cellular_replicative1.15609531
70MP0000569_abnormal_digit_pigmentation1.14613340
71MP0008469_abnormal_protein_level1.12411476
72MP0003448_altered_tumor_morphology1.10323667
73MP0005076_abnormal_cell_differentiation1.01527771
74MP0004883_abnormal_blood_vessel1.00372756
75MP0005023_abnormal_wound_healing0.99461577
76MP0003566_abnormal_cell_adhesion0.97785866
77MP0005390_skeleton_phenotype0.94425260
78MP0003075_altered_response_to0.94046716
79MP0000313_abnormal_cell_death0.93621393
80MP0000015_abnormal_ear_pigmentation0.92800315
81MP0005166_decreased_susceptibility_to0.88392843
82MP0003690_abnormal_glial_cell0.87806131
83MP0004957_abnormal_blastocyst_morpholog0.87466348
84MP0003705_abnormal_hypodermis_morpholog0.87234938
85MP0008058_abnormal_DNA_repair0.85797290
86MP0005670_abnormal_white_adipose0.85670281
87MP0001348_abnormal_lacrimal_gland0.84851601
88MP0001851_eye_inflammation0.84570353
89MP0003091_abnormal_cell_migration0.81585836
90MP0002138_abnormal_hepatobiliary_system0.81443920
91MP0003045_fibrosis0.81192344
92MP0000350_abnormal_cell_proliferation0.80848764
93MP0008961_abnormal_basal_metabolism0.79227970
94MP0002277_abnormal_respiratory_mucosa0.79147959
95MP0005377_hearing/vestibular/ear_phenot0.78410183
96MP0003878_abnormal_ear_physiology0.78410183
97MP0002009_preneoplasia0.77379111
98MP0000343_altered_response_to0.76149445
99MP0005164_abnormal_response_to0.76147702
100MP0000604_amyloidosis0.72818742
101MP0000371_diluted_coat_color0.71082505
102MP0008004_abnormal_stomach_pH0.70181094
103MP0003656_abnormal_erythrocyte_physiolo0.70064782
104MP0002928_abnormal_bile_duct0.69848729
105MP0001986_abnormal_taste_sensitivity0.69498532
106MP0003795_abnormal_bone_structure0.68624570
107MP0004858_abnormal_nervous_system0.68389754
108MP0001849_ear_inflammation0.68276627
109MP0008874_decreased_physiological_sensi0.66989585
110MP0004130_abnormal_muscle_cell0.65809905
111MP0003828_pulmonary_edema0.65363982
112MP0004185_abnormal_adipocyte_glucose0.64629509
113MP0002095_abnormal_skin_pigmentation0.64484064
114MP0002998_abnormal_bone_remodeling0.62771310
115MP0003279_aneurysm0.60787185
116MP0005621_abnormal_cell_physiology0.60322015
117MP0000477_abnormal_intestine_morphology0.60301946
118MP0002132_abnormal_respiratory_system0.59912316
119MP0009763_increased_sensitivity_to0.59793888
120MP0001730_embryonic_growth_arrest0.58744965
121MP0009764_decreased_sensitivity_to0.57857298
122MP0000249_abnormal_blood_vessel0.57834164
123MP0001663_abnormal_digestive_system0.57187475
124MP0005083_abnormal_biliary_tract0.56387378
125MP0005666_abnormal_adipose_tissue0.55906200
126MP0004264_abnormal_extraembryonic_tissu0.55832559
127MP0003453_abnormal_keratinocyte_physiol0.55403963
128MP0005381_digestive/alimentary_phenotyp0.54318586
129MP0000598_abnormal_liver_morphology0.53809531
130MP0003943_abnormal_hepatobiliary_system0.53295549

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.61133524
2Recurrent viral infections (HP:0004429)4.23276377
3Eczematoid dermatitis (HP:0000976)4.19149606
4Nasal polyposis (HP:0100582)4.17132161
5Recurrent fungal infections (HP:0002841)4.08295428
6Recurrent bacterial skin infections (HP:0005406)4.06311508
7IgM deficiency (HP:0002850)4.03441332
8Elevated erythrocyte sedimentation rate (HP:0003565)4.00027728
9Recurrent bronchitis (HP:0002837)3.89522002
10Chronic otitis media (HP:0000389)3.83858191
11Abnormality of the nasal mucosa (HP:0000433)3.82739457
12Panhypogammaglobulinemia (HP:0003139)3.72709858
13Gastrointestinal infarctions (HP:0005244)3.68120461
14Myositis (HP:0100614)3.58013001
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.54753364
16Cellulitis (HP:0100658)3.52098281
17T lymphocytopenia (HP:0005403)3.49066601
18Abnormality of the fingertips (HP:0001211)3.42102383
19Abnormality of T cell number (HP:0011839)3.33249577
20Gastrointestinal inflammation (HP:0004386)3.29831146
21Inflammation of the large intestine (HP:0002037)3.27809668
22Thyroiditis (HP:0100646)3.27310914
23Thrombocytosis (HP:0001894)3.22447633
24Abnormality of T cells (HP:0002843)3.19145703
25Encephalitis (HP:0002383)3.12669408
26Colitis (HP:0002583)3.11712176
27Combined immunodeficiency (HP:0005387)3.09347018
28Agammaglobulinemia (HP:0004432)3.08615155
29Severe combined immunodeficiency (HP:0004430)3.07804774
30Meningitis (HP:0001287)3.07276459
31Recurrent skin infections (HP:0001581)2.97404386
32Autoimmune thrombocytopenia (HP:0001973)2.97170578
33Pustule (HP:0200039)2.88400569
34Chronic mucocutaneous candidiasis (HP:0002728)2.87767022
35Recurrent cutaneous fungal infections (HP:0011370)2.87767022
36Abnormality of B cell number (HP:0010975)2.86224053
37B lymphocytopenia (HP:0010976)2.86224053
38Leukocytosis (HP:0001974)2.83478410
39Mediastinal lymphadenopathy (HP:0100721)2.81989220
40Abnormality of T cell physiology (HP:0011840)2.78408030
41Hypochromic anemia (HP:0001931)2.77867253
42Eosinophilia (HP:0001880)2.77445094
43Petechiae (HP:0000967)2.76270046
44Abnormality of macrophages (HP:0004311)2.71736553
45Prolonged bleeding time (HP:0003010)2.71721971
46Urticaria (HP:0001025)2.70599165
47Spontaneous hematomas (HP:0007420)2.69135734
48Keratoconjunctivitis sicca (HP:0001097)2.66477235
49Lymphopenia (HP:0001888)2.65761423
50Abnormality of cells of the lymphoid lineage (HP:0012140)2.63148604
51Abnormality of eosinophils (HP:0001879)2.61594356
52Vasculitis (HP:0002633)2.57084743
53Granulocytopenia (HP:0001913)2.56288855
54Episodic fever (HP:0001954)2.55456347
55Periodontitis (HP:0000704)2.55406222
56Vacuolated lymphocytes (HP:0001922)2.50653269
57Hypochromic microcytic anemia (HP:0004840)2.49058339
58Bronchitis (HP:0012387)2.48910111
59Interstitial pulmonary disease (HP:0006530)2.48422835
60Abnormal platelet function (HP:0011869)2.47494999
61Impaired platelet aggregation (HP:0003540)2.47494999
62Obstructive lung disease (HP:0006536)2.47318111
63Chronic obstructive pulmonary disease (HP:0006510)2.47318111
64Dysostosis multiplex (HP:0000943)2.46671490
65Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41968044
66Keratoconjunctivitis (HP:0001096)2.40440061
67Gingivitis (HP:0000230)2.35633823
68Recurrent gram-negative bacterial infections (HP:0005420)2.34818564
69Osteomyelitis (HP:0002754)2.33438582
70Increased IgE level (HP:0003212)2.31157600
71Papilloma (HP:0012740)2.30132015
72Verrucae (HP:0200043)2.30132015
73Epistaxis (HP:0000421)2.29494608
74Lymphoma (HP:0002665)2.29141148
75Obstructive sleep apnea (HP:0002870)2.25851413
76Orchitis (HP:0100796)2.24725831
77Slow saccadic eye movements (HP:0000514)2.21624480
78Arterial thrombosis (HP:0004420)2.21500591
79Gingival bleeding (HP:0000225)2.20376670
80Emphysema (HP:0002097)2.19006594
81Loss of speech (HP:0002371)2.18981771
82Pulmonary embolism (HP:0002204)2.16594152
83IgG deficiency (HP:0004315)2.16576287
84Recurrent sinusitis (HP:0011108)2.15942578
85Increased cerebral lipofuscin (HP:0011813)2.13672299
86Papilledema (HP:0001085)2.13659339
87Amyloidosis (HP:0011034)2.13299111
88Chest pain (HP:0100749)2.13259754
89Stomatitis (HP:0010280)2.10868473
90Gastrointestinal stroma tumor (HP:0100723)2.09800521
91Increased serum ferritin (HP:0003281)2.09443888
92Purpura (HP:0000979)2.09287256
93Increased IgM level (HP:0003496)2.09057745
94Albinism (HP:0001022)2.08454075
95Thoracic kyphosis (HP:0002942)2.04186385
96Peritonitis (HP:0002586)2.03107381
97Pulmonary infiltrates (HP:0002113)2.02478747
98Abnormality of glycolipid metabolism (HP:0010969)2.01902243
99Abnormality of liposaccharide metabolism (HP:0010968)2.01902243
100Abnormality of glycosphingolipid metabolism (HP:0004343)2.01902243
101Chronic diarrhea (HP:0002028)2.01760187
102Hemorrhage of the eye (HP:0011885)2.01244174
103Hypoplasia of the thymus (HP:0000778)1.99759612
104Spondylolisthesis (HP:0003302)1.98108656
105Abnormality of the thoracic spine (HP:0100711)1.97679293
106Segmental peripheral demyelination/remyelination (HP:0003481)1.97678379
107Recurrent pneumonia (HP:0006532)1.97562865
108Restrictive lung disease (HP:0002091)1.97050386
109Increased neuronal autofluorescent lipopigment (HP:0002074)1.97035436
110Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96776786
111Abnormality of polysaccharide metabolism (HP:0011012)1.96776786
112Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96776786
113IgA deficiency (HP:0002720)1.95951956
114Urinary glycosaminoglycan excretion (HP:0003541)1.95799956
115Mucopolysacchariduria (HP:0008155)1.95799956
116Chronic sinusitis (HP:0011109)1.95612604
117Anorexia (HP:0002039)1.95423688
118Poikiloderma (HP:0001029)1.95344157
119Microcytic anemia (HP:0001935)1.95196637
120Viral hepatitis (HP:0006562)1.94719369
121Malnutrition (HP:0004395)1.93509557
122Skin ulcer (HP:0200042)1.93101884
123Acne (HP:0001061)1.92037429
124Hypergammaglobulinemia (HP:0010702)1.90598064
125Premature loss of primary teeth (HP:0006323)1.90311772
126High pitched voice (HP:0001620)1.89424592
127Sepsis (HP:0100806)1.89194220
128Broad face (HP:0000283)1.88860226
129Hepatosplenomegaly (HP:0001433)1.88594924
130Optic neuritis (HP:0100653)1.88258514
131Retrobulbar optic neuritis (HP:0100654)1.88258514
132Hemoptysis (HP:0002105)1.87396150
133Abnormality of the pleura (HP:0002103)1.86229111
134Polygenic inheritance (HP:0010982)1.85665057
135Recurrent lower respiratory tract infections (HP:0002783)1.85534462
136Abnormality of the peritoneum (HP:0002585)1.84601649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.72482639
2PRPF4B3.14057287
3MAP3K102.75026340
4STK102.65308531
5EEF2K2.63802259
6ERN12.60957251
7TYK22.56563248
8ZAP702.34191454
9BLK2.34026270
10CSF1R2.23763260
11TGFBR22.18941704
12KIT2.15485165
13CDK122.14248364
14BTK2.06834521
15GRK61.96965560
16JAK31.91658394
17SIK11.87780066
18TXK1.81718945
19TBK11.76254683
20IRAK41.62532494
21ITK1.61067228
22NEK21.60817518
23SMG11.56936114
24SYK1.53523628
25IKBKE1.53387286
26MAP3K31.47094979
27CSK1.44663191
28TRIB31.38314372
29HCK1.36426465
30JAK11.33061469
31MAP2K31.32614653
32RPS6KA41.31383425
33TAOK31.30535571
34TEC1.30404767
35FGFR41.29302088
36IKBKB1.27685682
37CAMK1D1.27393450
38PKN21.26706441
39EPHB11.25806309
40LCK1.25196922
41FLT31.24858248
42LRRK21.22882716
43MAP3K11.19678041
44MAP3K141.14612238
45TESK21.12596258
46CDC42BPA1.10877402
47PIM11.10313660
48PTK61.03426422
49CDK41.02464678
50CLK11.01636173
51PAK40.99365132
52SIK20.98781650
53KDR0.98214085
54RPS6KB20.97963613
55KSR20.97156784
56FGR0.96703020
57CHUK0.95801754
58LYN0.93851317
59FES0.93793455
60TAOK20.88647061
61PDK10.88284190
62CAMK1G0.88123510
63STK40.87983330
64MAP3K130.84330701
65PDPK10.83798351
66RIPK40.83126290
67MAPKAPK30.82667767
68CAMKK10.82494771
69MAPK120.80515634
70FGFR30.80121526
71NLK0.78183384
72MARK30.77290980
73NME20.76301336
74HIPK20.74166937
75IRAK30.73737178
76JAK20.71287795
77MAP3K80.70024185
78MAPK70.69411569
79BRD40.68480889
80DYRK30.67219628
81MAP3K60.67026571
82TAOK10.66152101
83RIPK10.65579103
84CDK60.65293507
85ATR0.65177062
86MATK0.65138701
87TGFBR10.64959078
88STK380.64354841
89IRAK20.64301639
90ICK0.64013287
91ACVR1B0.63246430
92TTN0.63221241
93IRAK10.63188951
94PASK0.60974112
95TESK10.60916622
96MAP2K20.60189388
97CDC70.58558257
98MAP3K110.57882307
99CDK70.57412008
100PIM20.56655286
101RPS6KA20.55947685
102MARK20.55666807
103TRPM70.54648911
104RET0.54637657
105MAP3K70.54451326
106MAPKAPK20.52815109
107FYN0.51058894
108MAPK110.50578834
109YES10.49868195
110TNK20.49134891
111SIK30.48103513
112MAP2K60.47832141
113CDK90.47776566
114MAPK150.45341811
115PRKCH0.44652194
116DYRK1B0.42923043
117STK110.42416099
118BMX0.42136049
119PRKCQ0.41873405
120MTOR0.41138744
121SGK30.40619219
122RPS6KA60.38554709
123MELK0.38175385
124PRKD20.38105570
125SCYL20.36937712
126MAPK40.36454346
127WEE10.35774660
128BUB10.31437233
129RPS6KC10.30604802
130RPS6KL10.30604802

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.55769390
2B cell receptor signaling pathway_Homo sapiens_hsa046622.58589211
3Leishmaniasis_Homo sapiens_hsa051402.25959843
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.21645231
5Antigen processing and presentation_Homo sapiens_hsa046122.20203370
6Osteoclast differentiation_Homo sapiens_hsa043802.09970063
7DNA replication_Homo sapiens_hsa030302.05450443
8Other glycan degradation_Homo sapiens_hsa005112.03657124
9Measles_Homo sapiens_hsa051621.93869037
10Autoimmune thyroid disease_Homo sapiens_hsa053201.91322269
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.85984693
12T cell receptor signaling pathway_Homo sapiens_hsa046601.83308653
13Hematopoietic cell lineage_Homo sapiens_hsa046401.82977289
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.82604443
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.82312093
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77080921
17Herpes simplex infection_Homo sapiens_hsa051681.72207104
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.71723852
19Base excision repair_Homo sapiens_hsa034101.64905011
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54808090
21Acute myeloid leukemia_Homo sapiens_hsa052211.53352580
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53132682
23Mismatch repair_Homo sapiens_hsa034301.49756948
24Non-homologous end-joining_Homo sapiens_hsa034501.47165436
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47105541
26Shigellosis_Homo sapiens_hsa051311.43345990
27Toxoplasmosis_Homo sapiens_hsa051451.41688617
28Type I diabetes mellitus_Homo sapiens_hsa049401.39497673
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.38624312
30Hepatitis B_Homo sapiens_hsa051611.34361082
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.31930287
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31111933
33Chronic myeloid leukemia_Homo sapiens_hsa052201.31070022
34Apoptosis_Homo sapiens_hsa042101.30236937
35Influenza A_Homo sapiens_hsa051641.27888858
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26188885
37Legionellosis_Homo sapiens_hsa051341.25818757
38Staphylococcus aureus infection_Homo sapiens_hsa051501.24103674
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21968215
40Pertussis_Homo sapiens_hsa051331.19070107
41Tuberculosis_Homo sapiens_hsa051521.13965565
42Pancreatic cancer_Homo sapiens_hsa052121.13730078
43Epstein-Barr virus infection_Homo sapiens_hsa051691.13199661
44Chemokine signaling pathway_Homo sapiens_hsa040621.12083226
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12047005
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11955739
47Homologous recombination_Homo sapiens_hsa034401.08995119
48Cell cycle_Homo sapiens_hsa041101.08467018
49Notch signaling pathway_Homo sapiens_hsa043301.08059302
50Spliceosome_Homo sapiens_hsa030401.07482512
51Lysosome_Homo sapiens_hsa041421.07167971
52TNF signaling pathway_Homo sapiens_hsa046681.05339106
53Ribosome_Homo sapiens_hsa030101.04307111
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.03711644
55Malaria_Homo sapiens_hsa051441.02240496
56Viral myocarditis_Homo sapiens_hsa054161.00169009
57Platelet activation_Homo sapiens_hsa046110.99991352
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98448061
59p53 signaling pathway_Homo sapiens_hsa041150.98216933
60HTLV-I infection_Homo sapiens_hsa051660.98001078
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.96879527
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94784665
63African trypanosomiasis_Homo sapiens_hsa051430.94203741
64Viral carcinogenesis_Homo sapiens_hsa052030.93699544
65Renal cell carcinoma_Homo sapiens_hsa052110.92352996
66Choline metabolism in cancer_Homo sapiens_hsa052310.91237716
67Phagosome_Homo sapiens_hsa041450.90778739
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87678875
69Salmonella infection_Homo sapiens_hsa051320.85935344
70Endometrial cancer_Homo sapiens_hsa052130.85555200
71Colorectal cancer_Homo sapiens_hsa052100.82414687
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81782519
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80120725
74Small cell lung cancer_Homo sapiens_hsa052220.79403474
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.78314634
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.78245811
77GnRH signaling pathway_Homo sapiens_hsa049120.77971896
78Non-small cell lung cancer_Homo sapiens_hsa052230.75753088
79Allograft rejection_Homo sapiens_hsa053300.75720153
80VEGF signaling pathway_Homo sapiens_hsa043700.73920565
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.73372602
82Fanconi anemia pathway_Homo sapiens_hsa034600.71922518
83RNA transport_Homo sapiens_hsa030130.70060326
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68532278
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68367922
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68077141
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.67500022
88Rheumatoid arthritis_Homo sapiens_hsa053230.67290862
89Nucleotide excision repair_Homo sapiens_hsa034200.66513734
90Hepatitis C_Homo sapiens_hsa051600.66107375
91Graft-versus-host disease_Homo sapiens_hsa053320.65883655
92MAPK signaling pathway_Homo sapiens_hsa040100.63167828
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62876872
94ErbB signaling pathway_Homo sapiens_hsa040120.62634518
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62333697
96Amoebiasis_Homo sapiens_hsa051460.59435252
97Asthma_Homo sapiens_hsa053100.57335159
98Type II diabetes mellitus_Homo sapiens_hsa049300.57180141
99Prolactin signaling pathway_Homo sapiens_hsa049170.57152913
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56627229
101RNA degradation_Homo sapiens_hsa030180.56109796
102Lysine degradation_Homo sapiens_hsa003100.55740806
103Dorso-ventral axis formation_Homo sapiens_hsa043200.55580104
104Prostate cancer_Homo sapiens_hsa052150.54869085
105Estrogen signaling pathway_Homo sapiens_hsa049150.53754921
106Pentose phosphate pathway_Homo sapiens_hsa000300.53649432
107Insulin signaling pathway_Homo sapiens_hsa049100.51714406
108Endocytosis_Homo sapiens_hsa041440.51573952
109mTOR signaling pathway_Homo sapiens_hsa041500.51477512
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51425903
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48312142
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47168685
113Rap1 signaling pathway_Homo sapiens_hsa040150.47000231
114Glioma_Homo sapiens_hsa052140.45985980
115Pyrimidine metabolism_Homo sapiens_hsa002400.45931775
116Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45566485
117mRNA surveillance pathway_Homo sapiens_hsa030150.45231819
118MicroRNAs in cancer_Homo sapiens_hsa052060.44700041
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44695687
120Insulin resistance_Homo sapiens_hsa049310.44158179
121Sulfur relay system_Homo sapiens_hsa041220.43896364
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42886301
123HIF-1 signaling pathway_Homo sapiens_hsa040660.42728206
124N-Glycan biosynthesis_Homo sapiens_hsa005100.42446514
125Caffeine metabolism_Homo sapiens_hsa002320.42067345
126Pathways in cancer_Homo sapiens_hsa052000.41577970
127Inositol phosphate metabolism_Homo sapiens_hsa005620.40670176
128FoxO signaling pathway_Homo sapiens_hsa040680.39946512
129One carbon pool by folate_Homo sapiens_hsa006700.38814963
130Basal transcription factors_Homo sapiens_hsa030220.38480385
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37333548

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