LRFN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.47210552
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.29965264
3locomotory exploration behavior (GO:0035641)6.02077996
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.97244864
5vocalization behavior (GO:0071625)5.76297938
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.59339860
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.58910928
8layer formation in cerebral cortex (GO:0021819)5.52524677
9synaptic vesicle exocytosis (GO:0016079)5.29769054
10glutamate secretion (GO:0014047)5.27604557
11protein localization to synapse (GO:0035418)5.11045653
12neuron cell-cell adhesion (GO:0007158)5.09408988
13regulation of glutamate receptor signaling pathway (GO:1900449)5.05635720
14exploration behavior (GO:0035640)5.05421671
15regulation of synaptic vesicle exocytosis (GO:2000300)4.97110404
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.95050043
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.95050043
18modulation by symbiont of host immune response (GO:0052553)4.95050043
19positive regulation by symbiont of host defense response (GO:0052509)4.95050043
20modulation by symbiont of host defense response (GO:0052031)4.95050043
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.95050043
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.88496850
23dendritic spine morphogenesis (GO:0060997)4.80511879
24positive regulation of synaptic transmission, GABAergic (GO:0032230)4.68682679
25negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.60642054
26negative regulation of cell killing (GO:0031342)4.53980850
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.53980850
28proline transport (GO:0015824)4.45774954
29neurotransmitter secretion (GO:0007269)4.42036609
30ionotropic glutamate receptor signaling pathway (GO:0035235)4.41156954
31regulation of neuronal synaptic plasticity (GO:0048168)4.39865797
32regulation of long-term neuronal synaptic plasticity (GO:0048169)4.39231124
33positive regulation of synapse maturation (GO:0090129)4.31871195
34regulation of synaptic vesicle transport (GO:1902803)4.31177938
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.23880922
36long-term memory (GO:0007616)4.19099230
37cell migration in hindbrain (GO:0021535)4.12920964
38regulation of synapse structural plasticity (GO:0051823)4.11638237
39neuron recognition (GO:0008038)4.03586904
40neuronal action potential propagation (GO:0019227)3.92880233
41postsynaptic membrane organization (GO:0001941)3.87136230
42synaptic transmission, glutamatergic (GO:0035249)3.84195161
43glutamate receptor signaling pathway (GO:0007215)3.82627741
44gamma-aminobutyric acid transport (GO:0015812)3.79660257
45neurotransmitter-gated ion channel clustering (GO:0072578)3.79476044
46axonal fasciculation (GO:0007413)3.79254927
47negative regulation of erythrocyte differentiation (GO:0045647)3.79018487
48leukocyte aggregation (GO:0070486)3.77858831
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.73813578
50macrophage activation involved in immune response (GO:0002281)3.71905443
51activation of protein kinase A activity (GO:0034199)3.69598783
52positive regulation of membrane potential (GO:0045838)3.67343598
53dendrite morphogenesis (GO:0048813)3.66874078
54neuromuscular process controlling balance (GO:0050885)3.66017988
55synaptic vesicle endocytosis (GO:0048488)3.58663860
56leukocyte migration involved in inflammatory response (GO:0002523)3.58289750
57regulation of dendritic spine morphogenesis (GO:0061001)3.55997285
58negative regulation of microtubule polymerization (GO:0031115)3.55379568
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.52083395
60neuron-neuron synaptic transmission (GO:0007270)3.46920467
61neurotransmitter transport (GO:0006836)3.46672697
62response to host immune response (GO:0052572)3.46278092
63response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.46278092
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.46096610
65regulation of postsynaptic membrane potential (GO:0060078)3.44827362
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.44269399
67cellular potassium ion homeostasis (GO:0030007)3.42117880
68sodium ion export (GO:0071436)3.42002387
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.40760150
70regulation of synaptic plasticity (GO:0048167)3.36968141
71central nervous system projection neuron axonogenesis (GO:0021952)3.34668625
72cerebellar Purkinje cell differentiation (GO:0021702)3.32683951
73response to peptidoglycan (GO:0032494)3.31606781
74auditory behavior (GO:0031223)3.31206945
75transmission of nerve impulse (GO:0019226)3.30788991
76regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28562182
77innervation (GO:0060384)3.27519287
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.25453944
79response to auditory stimulus (GO:0010996)3.24652270
80regulation of neurotransmitter secretion (GO:0046928)3.23764766
81dendritic spine organization (GO:0097061)3.22858684
82positive regulation of dendritic spine morphogenesis (GO:0061003)3.22024978
83cell communication by electrical coupling (GO:0010644)3.21858733
84regulation of chromatin binding (GO:0035561)3.21110046
85regulation of neurotransmitter levels (GO:0001505)3.18424322
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18416119
87pyrimidine nucleobase catabolic process (GO:0006208)3.18165119
88regulation of synapse maturation (GO:0090128)3.17937775
89synapse assembly (GO:0007416)3.17110768
90cerebellar Purkinje cell layer development (GO:0021680)3.16953277
91positive regulation of dendritic spine development (GO:0060999)3.16020897
92positive regulation of CREB transcription factor activity (GO:0032793)3.14759982
93establishment of nucleus localization (GO:0040023)3.14275960
94establishment of mitochondrion localization (GO:0051654)3.13570433
95cerebellum development (GO:0021549)3.12661393
96neutrophil activation involved in immune response (GO:0002283)3.12534021
97intraspecies interaction between organisms (GO:0051703)3.12356773
98social behavior (GO:0035176)3.12356773
99establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.12332635
100mitochondrion transport along microtubule (GO:0047497)3.12332635
101regulation of vesicle fusion (GO:0031338)3.10709721
102neutrophil mediated immunity (GO:0002446)3.10280981
103cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.10243367
104behavioral fear response (GO:0001662)3.09820375
105behavioral defense response (GO:0002209)3.09820375
106positive regulation of mast cell activation (GO:0033005)3.09076978
107detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.08895506
108detection of temperature stimulus involved in sensory perception (GO:0050961)3.08895506
109regulation of synaptic transmission, GABAergic (GO:0032228)3.08825457
110regulation of regulated secretory pathway (GO:1903305)3.07611840
111negative regulation of lymphocyte mediated immunity (GO:0002707)3.06164445
112regulation of synaptic transmission, glutamatergic (GO:0051966)3.05906310
113antigen processing and presentation of endogenous antigen (GO:0019883)3.04552748
114antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.03939436
115negative regulation of cAMP-mediated signaling (GO:0043951)3.03553036
116organelle transport along microtubule (GO:0072384)3.03214916
117learning (GO:0007612)3.02562811
118cerebellar granule cell differentiation (GO:0021707)2.99345073
119gamma-aminobutyric acid signaling pathway (GO:0007214)2.99305549
120regulation of ARF protein signal transduction (GO:0032012)2.98743295
121neuromuscular process (GO:0050905)2.98233586
122clathrin coat assembly (GO:0048268)2.97908480
123axon extension (GO:0048675)2.97864480
124respiratory burst (GO:0045730)2.97240265
125regulation of calcium ion-dependent exocytosis (GO:0017158)2.96683926
126regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95844224
127regulation of dendritic spine development (GO:0060998)2.94612199
128neutrophil activation (GO:0042119)2.94480976
129membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94271888
130synapse organization (GO:0050808)2.94148926
131axon cargo transport (GO:0008088)2.94075168
132myeloid leukocyte mediated immunity (GO:0002444)2.93825983
133presynaptic membrane assembly (GO:0097105)2.93673267
134neuromuscular process controlling posture (GO:0050884)2.92911394
135antigen processing and presentation via MHC class Ib (GO:0002475)2.92778471
136long-term synaptic potentiation (GO:0060291)2.92736525
137response to interleukin-15 (GO:0070672)2.92056437
138cell-cell junction maintenance (GO:0045217)2.91846341
139positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91023705
140fear response (GO:0042596)2.90629013
141response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90435533
142response to host (GO:0075136)2.90435533
143response to host defenses (GO:0052200)2.90435533
144vesicle transport along microtubule (GO:0047496)2.90329222
145regulation of mast cell degranulation (GO:0043304)2.90113365
146regulation of interferon-beta biosynthetic process (GO:0045357)2.88542613
147intracellular estrogen receptor signaling pathway (GO:0030520)2.85179976
148positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.82564710
149peptidyl-arginine omega-N-methylation (GO:0035247)2.81644147
150positive regulation of gamma-delta T cell activation (GO:0046645)2.81557255
151respiratory system process (GO:0003016)2.81496216
152peptidyl-tyrosine autophosphorylation (GO:0038083)2.79446619
153behavioral response to nicotine (GO:0035095)2.77538880
154positive regulation of mast cell degranulation (GO:0043306)2.75979624
155positive regulation of mast cell activation involved in immune response (GO:0033008)2.75979624
156positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.74095187
157histone arginine methylation (GO:0034969)2.73460071
158cellular response to interleukin-15 (GO:0071350)2.73459279
159regulation of leukocyte degranulation (GO:0043300)2.72848950
160positive regulation of regulated secretory pathway (GO:1903307)2.69296130
161detection of other organism (GO:0098543)2.66410804
162negative regulation of interleukin-12 production (GO:0032695)2.62998798
163regulation of mast cell activation involved in immune response (GO:0033006)2.61667516
164regulation of ARF GTPase activity (GO:0032312)2.61226974
165cranial nerve morphogenesis (GO:0021602)2.61093466
166negative regulation of leukocyte mediated immunity (GO:0002704)2.59810657
167detection of bacterium (GO:0016045)2.59695060
168peripheral nervous system neuron development (GO:0048935)2.57147696
169microglial cell activation (GO:0001774)2.52218398
170positive regulation of T cell apoptotic process (GO:0070234)2.51744028
171cellular extravasation (GO:0045123)2.51630721
172negative regulation of histone acetylation (GO:0035067)2.51449737
173regulation of respiratory system process (GO:0044065)2.51181633
174regulation of B cell receptor signaling pathway (GO:0050855)2.50119137
175signal complex assembly (GO:0007172)2.50090788

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.27857331
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19611378
3VDR_21846776_ChIP-Seq_THP-1_Human3.18655686
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08562988
5REST_21632747_ChIP-Seq_MESCs_Mouse3.07505151
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97383276
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.80767927
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79406246
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79406246
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.78170688
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.77894392
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.67757811
13MYC_22102868_ChIP-Seq_BL_Human2.67650390
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.67003182
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.66119438
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.63703685
17GBX2_23144817_ChIP-Seq_PC3_Human2.60213467
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.53736699
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51803739
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50981872
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50372681
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49914630
23DROSHA_22980978_ChIP-Seq_HELA_Human2.47637837
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44187684
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.41620388
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.39014601
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37378497
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.34354983
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.34009542
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27374867
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.26339859
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.22062633
33P68_20966046_ChIP-Seq_HELA_Human2.04989142
34* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.03272563
35ERG_21242973_ChIP-ChIP_JURKAT_Human2.00736165
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.98334313
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96363080
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90430042
39* TET1_21451524_ChIP-Seq_MESCs_Mouse1.89957152
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86147685
41TCF7_22412390_ChIP-Seq_EML_Mouse1.82239748
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.77931881
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.73884515
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.70965582
45AR_21572438_ChIP-Seq_LNCaP_Human1.66962196
46MAF_26560356_Chip-Seq_TH2_Human1.66515043
47KDM2B_26808549_Chip-Seq_K562_Human1.65145801
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.63476293
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.63072587
50VDR_24763502_ChIP-Seq_THP-1_Human1.62421501
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61146358
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59904284
53ELF1_20517297_ChIP-Seq_JURKAT_Human1.57872055
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56036302
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54870275
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54869871
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.54638180
58MAF_26560356_Chip-Seq_TH1_Human1.53781519
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.53423398
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51759531
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51615954
62RING1B_27294783_Chip-Seq_NPCs_Mouse1.51222207
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51155498
64BCL6_27268052_Chip-Seq_Bcells_Human1.49802570
65RACK7_27058665_Chip-Seq_MCF-7_Human1.49627229
66UTX_26944678_Chip-Seq_JUKART_Human1.49354428
67ZNF274_21170338_ChIP-Seq_K562_Hela1.48328964
68CREB1_26743006_Chip-Seq_LNCaP_Human1.46557292
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44939107
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44188143
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43096706
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41661310
73BCOR_27268052_Chip-Seq_Bcells_Human1.39834329
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.39138441
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38878034
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35001575
77SA1_27219007_Chip-Seq_Bcells_Human1.32872467
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29249218
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27845845
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27513651
81PHF8_20622854_ChIP-Seq_HELA_Human1.27444357
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26134319
83AR_19668381_ChIP-Seq_PC3_Human1.21407846
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20872710
85E2F1_20622854_ChIP-Seq_HELA_Human1.20410052
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19750450
87* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19682840
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19357983
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19233284
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.18985704
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18917890
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18915102
93XRN2_22483619_ChIP-Seq_HELA_Human1.18685433
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18542427
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18462537
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17905520
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17437289
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.17408701
99CTCF_26484167_Chip-Seq_Bcells_Mouse1.17057169
100PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16429540
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14275103
102SMAD4_21799915_ChIP-Seq_A2780_Human1.14268841
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14034591
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13703042
105CTCF_27219007_Chip-Seq_Bcells_Human1.13251993
106CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12755927
107RNF2_27304074_Chip-Seq_NSC_Mouse1.12551515
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12017922
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11190536
110RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11153522
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.10994387
112SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.10926065
113SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09310109
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09085200
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.09016232
116FOXP1_21924763_ChIP-Seq_HESCs_Human1.08648588
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07581803
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07287263
119YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06835186
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06773396
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06766519
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06611249
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05566602
124CTCF_21964334_ChIP-Seq_BJAB-B_Human1.05490925
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05076935
126TET1_21490601_ChIP-Seq_MESCs_Mouse1.04960853
127STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04695643
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02442251
129SMAD3_21741376_ChIP-Seq_ESCs_Human1.01591308
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98586626
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98456123
132LXR_22292898_ChIP-Seq_THP-1_Human0.95458499
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95124038
134SMAD3_21741376_ChIP-Seq_EPCs_Human0.93195851
135AR_25329375_ChIP-Seq_VCAP_Human0.92110648
136KDM2B_26808549_Chip-Seq_JURKAT_Human0.90752977
137TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90150153
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89319160
139* KDM2B_26808549_Chip-Seq_DND41_Human0.88586968
140* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86666593
141P300_19829295_ChIP-Seq_ESCs_Human0.85542846
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.85256781
143STAT3_23295773_ChIP-Seq_U87_Human0.83706763
144OCT4_19829295_ChIP-Seq_ESCs_Human0.81681749
145IGF1R_20145208_ChIP-Seq_DFB_Human0.80632089
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.79840019
147SMC4_20622854_ChIP-Seq_HELA_Human0.79582683
148ARNT_22903824_ChIP-Seq_MCF-7_Human0.78128527
149AHR_22903824_ChIP-Seq_MCF-7_Human0.77770416
150NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77507297
151CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77407010
152KLF4_19829295_ChIP-Seq_ESCs_Human0.76599936
153ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76454212
154EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76224403
155TAF15_26573619_Chip-Seq_HEK293_Human0.75924588
156MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.75433495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.40554889
2MP0003880_abnormal_central_pattern4.31817325
3MP0003635_abnormal_synaptic_transmissio4.08131510
4MP0004270_analgesia3.86333831
5MP0002063_abnormal_learning/memory/cond3.29993459
6MP0005423_abnormal_somatic_nervous3.20190389
7MP0009745_abnormal_behavioral_response3.18217551
8MP0001968_abnormal_touch/_nociception3.07701974
9MP0002064_seizures2.90563245
10MP0002734_abnormal_mechanical_nocicepti2.80787340
11MP0002572_abnormal_emotion/affect_behav2.74174872
12MP0002735_abnormal_chemical_nociception2.63490588
13MP0009046_muscle_twitch2.58654599
14MP0004858_abnormal_nervous_system2.55169254
15MP0003436_decreased_susceptibility_to2.49982201
16MP0002733_abnormal_thermal_nociception2.31561699
17MP0002249_abnormal_larynx_morphology2.29747524
18MP0001486_abnormal_startle_reflex2.24992932
19MP0002736_abnormal_nociception_after2.23841415
20MP0000778_abnormal_nervous_system2.23374063
21MP0002272_abnormal_nervous_system2.21752920
22MP0001440_abnormal_grooming_behavior2.20119082
23MP0003303_peritoneal_inflammation2.17426993
24MP0001970_abnormal_pain_threshold2.13481785
25MP0002184_abnormal_innervation2.10764821
26MP0003724_increased_susceptibility_to1.94464414
27MP0000678_abnormal_parathyroid_gland1.93597727
28MP0004811_abnormal_neuron_physiology1.92295493
29MP0000955_abnormal_spinal_cord1.86865815
30MP0003329_amyloid_beta_deposits1.85719480
31MP0001501_abnormal_sleep_pattern1.85264103
32MP0006276_abnormal_autonomic_nervous1.84385094
33MP0009780_abnormal_chondrocyte_physiolo1.83583670
34MP0002557_abnormal_social/conspecific_i1.82898511
35MP0002067_abnormal_sensory_capabilities1.77730726
36MP0002277_abnormal_respiratory_mucosa1.72560199
37MP0003122_maternal_imprinting1.67193384
38MP0002909_abnormal_adrenal_gland1.66623186
39MP0008569_lethality_at_weaning1.65152119
40MP0004924_abnormal_behavior1.64984269
41MP0005386_behavior/neurological_phenoty1.64984269
42MP0009278_abnormal_bone_marrow1.63241329
43MP0002822_catalepsy1.60477885
44MP0010386_abnormal_urinary_bladder1.58434490
45MP0003283_abnormal_digestive_organ1.54269002
46MP0002882_abnormal_neuron_morphology1.53947747
47MP0001346_abnormal_lacrimal_gland1.47185614
48MP0003879_abnormal_hair_cell1.44758533
49MP0002066_abnormal_motor_capabilities/c1.40151301
50MP0004885_abnormal_endolymph1.39292609
51MP0003787_abnormal_imprinting1.34913036
52MP0002152_abnormal_brain_morphology1.34805793
53MP0006292_abnormal_olfactory_placode1.24899490
54MP0005451_abnormal_body_composition1.24406670
55MP0001984_abnormal_olfaction1.23448396
56MP0002419_abnormal_innate_immunity1.22931292
57MP0001529_abnormal_vocalization1.21450925
58MP0002132_abnormal_respiratory_system1.20370059
59MP0002396_abnormal_hematopoietic_system1.15616267
60MP0003878_abnormal_ear_physiology1.15310954
61MP0005377_hearing/vestibular/ear_phenot1.15310954
62MP0000703_abnormal_thymus_morphology1.15016436
63MP0005645_abnormal_hypothalamus_physiol1.14860869
64MP0002420_abnormal_adaptive_immunity1.12333083
65MP0005025_abnormal_response_to1.10539610
66MP0001819_abnormal_immune_cell1.10267565
67MP0004145_abnormal_muscle_electrophysio1.10203004
68MP0003123_paternal_imprinting1.08325553
69MP0005499_abnormal_olfactory_system1.08186954
70MP0005394_taste/olfaction_phenotype1.08186954
71MP0008260_abnormal_autophagy1.07774259
72MP0003633_abnormal_nervous_system1.07517759
73MP0003938_abnormal_ear_development1.07318912
74MP0008961_abnormal_basal_metabolism1.06684057
75MP0004142_abnormal_muscle_tone1.06556040
76MP0003861_abnormal_nervous_system1.06041393
77MP0001348_abnormal_lacrimal_gland1.06022731
78MP0009333_abnormal_splenocyte_physiolog1.05098781
79MP0005671_abnormal_response_to1.03913214
80MP0001800_abnormal_humoral_immune1.02141745
81MP0003942_abnormal_urinary_system1.02032557
82MP0002723_abnormal_immune_serum1.02004776
83MP0000049_abnormal_middle_ear1.01627038
84MP0002398_abnormal_bone_marrow1.00797864
85MP0000681_abnormal_thyroid_gland0.99299054
86MP0001986_abnormal_taste_sensitivity0.98122567
87MP0005076_abnormal_cell_differentiation0.97900210
88MP0003631_nervous_system_phenotype0.95858434
89MP0003119_abnormal_digestive_system0.95140985
90MP0000569_abnormal_digit_pigmentation0.94316147
91MP0002163_abnormal_gland_morphology0.92817104
92MP0001905_abnormal_dopamine_level0.92565015
93MP0004381_abnormal_hair_follicle0.92225954
94MP0005623_abnormal_meninges_morphology0.91717686
95MP0001502_abnormal_circadian_rhythm0.91488333
96MP0005000_abnormal_immune_tolerance0.91320712
97MP0000631_abnormal_neuroendocrine_gland0.88631665
98MP0002752_abnormal_somatic_nervous0.88283658
99MP0005646_abnormal_pituitary_gland0.87616297
100MP0002069_abnormal_eating/drinking_beha0.87361651
101MP0008872_abnormal_physiological_respon0.87295429
102MP0000716_abnormal_immune_system0.86137853
103MP0002653_abnormal_ependyma_morphology0.85986724
104MP0005310_abnormal_salivary_gland0.84000813
105MP0004130_abnormal_muscle_cell0.83463780
106MP0003634_abnormal_glial_cell0.82347276
107MP0001188_hyperpigmentation0.79640056
108MP0005187_abnormal_penis_morphology0.79310249
109MP0003315_abnormal_perineum_morphology0.77880362
110MP0000537_abnormal_urethra_morphology0.77854660
111MP0001790_abnormal_immune_system0.77682978
112MP0005387_immune_system_phenotype0.77682978
113MP0003632_abnormal_nervous_system0.77444270
114MP0001835_abnormal_antigen_presentation0.76667803
115MP0002229_neurodegeneration0.75775406
116MP0002928_abnormal_bile_duct0.75423417
117MP0003121_genomic_imprinting0.75301494
118MP0002452_abnormal_antigen_presenting0.74318749
119MP0000751_myopathy0.73313164
120MP0001963_abnormal_hearing_physiology0.73066223
121MP0001919_abnormal_reproductive_system0.73027623
122MP0001873_stomach_inflammation0.71989308
123MP0004133_heterotaxia0.70697133
124MP0010234_abnormal_vibrissa_follicle0.70693378
125MP0003172_abnormal_lysosome_physiology0.69790626
126MP0008874_decreased_physiological_sensi0.69286932
127MP0004233_abnormal_muscle_weight0.68720886
128MP0002751_abnormal_autonomic_nervous0.68167053
129MP0003890_abnormal_embryonic-extraembry0.68054446
130MP0004742_abnormal_vestibular_system0.67475211
131MP0004085_abnormal_heartbeat0.66392862
132MP0000604_amyloidosis0.65932818
133MP0003137_abnormal_impulse_conducting0.64349661
134MP0010769_abnormal_survival0.63748649
135MP0001177_atelectasis0.63325439
136MP0002234_abnormal_pharynx_morphology0.63302948
137MP0001943_abnormal_respiration0.62913590
138MP0000534_abnormal_ureter_morphology0.61646125
139MP0010770_preweaning_lethality0.60419683
140MP0002082_postnatal_lethality0.60419683
141MP0010768_mortality/aging0.60257925
142MP0005535_abnormal_body_temperature0.58896832
143MP0002081_perinatal_lethality0.58546969
144MP0006072_abnormal_retinal_apoptosis0.57802976
145MP0002638_abnormal_pupillary_reflex0.57741508

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.34805204
2Focal motor seizures (HP:0011153)5.82314264
3Visual hallucinations (HP:0002367)5.56684141
4Focal seizures (HP:0007359)5.02527765
5Recurrent bacterial skin infections (HP:0005406)4.30040395
6Recurrent abscess formation (HP:0002722)4.21577430
7Hypochromic microcytic anemia (HP:0004840)4.05345839
8Epileptic encephalopathy (HP:0200134)4.03206375
9Progressive cerebellar ataxia (HP:0002073)3.96990208
10Mutism (HP:0002300)3.84879697
11Supranuclear gaze palsy (HP:0000605)3.75263631
12Hypochromic anemia (HP:0001931)3.70641547
13Eczematoid dermatitis (HP:0000976)3.70508106
14Abnormality of the aortic arch (HP:0012303)3.65709892
15Atonic seizures (HP:0010819)3.65513802
16Absence seizures (HP:0002121)3.60135721
17Obstructive lung disease (HP:0006536)3.59555741
18Chronic obstructive pulmonary disease (HP:0006510)3.59555741
19Ankle clonus (HP:0011448)3.57275909
20Action tremor (HP:0002345)3.46033375
21Febrile seizures (HP:0002373)3.38582494
22Abnormality of the lower motor neuron (HP:0002366)3.36398915
23Truncus arteriosus (HP:0001660)3.29753691
24Dialeptic seizures (HP:0011146)3.26552584
25Double outlet right ventricle (HP:0001719)3.25891869
26Congenital malformation of the right heart (HP:0011723)3.25891869
27Myositis (HP:0100614)3.23457559
28Generalized tonic-clonic seizures (HP:0002069)3.19812393
29Amyotrophic lateral sclerosis (HP:0007354)3.07679196
30Papilledema (HP:0001085)3.07356318
31Broad-based gait (HP:0002136)3.07264779
32Genetic anticipation (HP:0003743)3.06183920
33Depression (HP:0000716)3.03932398
34Amblyopia (HP:0000646)3.03650738
35Obstructive sleep apnea (HP:0002870)2.99290206
36Poor eye contact (HP:0000817)2.99235900
37Urinary bladder sphincter dysfunction (HP:0002839)2.98593409
38Orchitis (HP:0100796)2.92631150
39Birth length less than 3rd percentile (HP:0003561)2.92609186
40Impaired vibration sensation in the lower limbs (HP:0002166)2.86233169
41Excessive salivation (HP:0003781)2.84707882
42Drooling (HP:0002307)2.84707882
43Gastrointestinal infarctions (HP:0005244)2.74208175
44Abnormal social behavior (HP:0012433)2.73742745
45Impaired social interactions (HP:0000735)2.73742745
46Stomatitis (HP:0010280)2.70210050
47Optic neuritis (HP:0100653)2.67450338
48Retrobulbar optic neuritis (HP:0100654)2.67450338
49Megalencephaly (HP:0001355)2.66739813
50Hemiparesis (HP:0001269)2.66655899
51Cerebral inclusion bodies (HP:0100314)2.66147256
52Postural instability (HP:0002172)2.66085405
53Abnormality of the fingertips (HP:0001211)2.65680125
54Microretrognathia (HP:0000308)2.62840586
55Diplopia (HP:0000651)2.60355003
56Abnormality of binocular vision (HP:0011514)2.60355003
57Abnormality of the corticospinal tract (HP:0002492)2.60109240
58Urinary urgency (HP:0000012)2.59110538
59Episodic fever (HP:0001954)2.58867223
60Truncal ataxia (HP:0002078)2.58401207
61Insomnia (HP:0100785)2.58139134
62Mediastinal lymphadenopathy (HP:0100721)2.56632779
63Apathy (HP:0000741)2.56092948
64Limb dystonia (HP:0002451)2.55894567
65Dysdiadochokinesis (HP:0002075)2.54599561
66Abnormal eating behavior (HP:0100738)2.53315217
67Elevated erythrocyte sedimentation rate (HP:0003565)2.52037379
68Broad distal phalanx of finger (HP:0009836)2.51858357
69Impaired smooth pursuit (HP:0007772)2.51032015
70Anxiety (HP:0000739)2.42894185
71Pointed chin (HP:0000307)2.42037968
72Anomalous pulmonary venous return (HP:0010772)2.39249010
73Insidious onset (HP:0003587)2.39031769
74Termporal pattern (HP:0011008)2.39031769
75Hyperventilation (HP:0002883)2.38993435
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38607008
77Abnormality of macrophages (HP:0004311)2.37753064
78Dysmetria (HP:0001310)2.37089118
79Annular pancreas (HP:0001734)2.36515778
80Breast hypoplasia (HP:0003187)2.35711444
81Recurrent gram-negative bacterial infections (HP:0005420)2.34283801
82Spastic gait (HP:0002064)2.34142679
83Encephalitis (HP:0002383)2.31850797
84Torticollis (HP:0000473)2.31330661
85Recurrent skin infections (HP:0001581)2.30700016
86Gaze-evoked nystagmus (HP:0000640)2.30637228
87Neurofibrillary tangles (HP:0002185)2.29710167
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.29524556
89Bowel incontinence (HP:0002607)2.28573459
90Stereotypic behavior (HP:0000733)2.28361687
91Bradykinesia (HP:0002067)2.27794137
92Diminished motivation (HP:0000745)2.27673778
93Increased IgE level (HP:0003212)2.27379527
94Agitation (HP:0000713)2.27138558
95Meningitis (HP:0001287)2.26579314
96Inappropriate behavior (HP:0000719)2.23404764
97Abnormal large intestine physiology (HP:0012700)2.22017605
98Neoplasm of the adrenal cortex (HP:0100641)2.19099418
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.18237692
100Progressive inability to walk (HP:0002505)2.17242588
101Abnormality of ocular smooth pursuit (HP:0000617)2.16162520
102Epileptiform EEG discharges (HP:0011182)2.15259930
103Abnormality of the columella (HP:0009929)2.14953358
104Hemiplegia (HP:0002301)2.14673091
105EEG with generalized epileptiform discharges (HP:0011198)2.13357444
106Focal dystonia (HP:0004373)2.12542974
107Polyphagia (HP:0002591)2.11753069
108Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11386688
109Optic nerve coloboma (HP:0000588)2.07233486
110Hypsarrhythmia (HP:0002521)2.06877445
111Septate vagina (HP:0001153)2.05526884
112Absent speech (HP:0001344)2.04483927
113Abnormality of the heme biosynthetic pathway (HP:0010472)2.03719994
114Sleep apnea (HP:0010535)2.02925922
115Scanning speech (HP:0002168)2.01956642
116Aqueductal stenosis (HP:0002410)2.01204884
117Delusions (HP:0000746)2.00955316
118Akinesia (HP:0002304)2.00572287
119Tetany (HP:0001281)1.98086989
120Asymmetric growth (HP:0100555)1.97882168
121Fetal akinesia sequence (HP:0001989)1.97444506
122Hyperacusis (HP:0010780)1.97433618
123Lower limb muscle weakness (HP:0007340)1.97322678
124Petechiae (HP:0000967)1.95812265
125Abnormal connection of the cardiac segments (HP:0011545)1.95406736
126Abnormal ventriculo-arterial connection (HP:0011563)1.95406736
127Transposition of the great arteries (HP:0001669)1.95406736
128Intention tremor (HP:0002080)1.94415233
129Abnormality of the phalanges of the hallux (HP:0010057)1.94239907
130Abnormality of the pulmonary veins (HP:0011718)1.91190826
131Morphological abnormality of the pyramidal tract (HP:0002062)1.90930915
132Neonatal hypoglycemia (HP:0001998)1.89641389
133Ventricular fibrillation (HP:0001663)1.88839754
134Generalized hypotonia (HP:0001290)1.88325626
135Rapidly progressive (HP:0003678)1.87939359
136Recurrent fungal infections (HP:0002841)1.87330285
137Hyperthyroidism (HP:0000836)1.87303030
138Bronchomalacia (HP:0002780)1.86977852
139Hypoventilation (HP:0002791)1.86955988
140Craniofacial dystonia (HP:0012179)1.84924734
141Abnormality of the astrocytes (HP:0100707)1.84585455
142Astrocytoma (HP:0009592)1.84585455
143Diastasis recti (HP:0001540)1.84193649
144Aplasia/Hypoplasia of the brainstem (HP:0007362)1.81998951
145Hypoplasia of the brainstem (HP:0002365)1.81998951
146Ankyloglossia (HP:0010296)1.81836410
147Status epilepticus (HP:0002133)1.81018224
148Microcytic anemia (HP:0001935)1.80268743
149Failure to thrive in infancy (HP:0001531)1.80089610
150Impaired vibratory sensation (HP:0002495)1.79363874
151Urticaria (HP:0001025)1.78939821
152Generalized myoclonic seizures (HP:0002123)1.78318142
153Neuronal loss in central nervous system (HP:0002529)1.77318049
154Inability to walk (HP:0002540)1.76537262
155Clonus (HP:0002169)1.76392383
156Neoplasm of the peripheral nervous system (HP:0100007)1.76028397
157Deep palmar crease (HP:0006191)1.75380443
158Gingivitis (HP:0000230)1.73614262
159Hypertensive crisis (HP:0100735)1.72093289
160Abnormal delayed hypersensitivity skin test (HP:0002963)1.70663137
161Cellulitis (HP:0100658)1.69253531
162Pallor (HP:0000980)1.69211536
163Unilateral renal agenesis (HP:0000122)1.68705405
164Peripheral hypomyelination (HP:0007182)1.68235495
165Hypoplastic left heart (HP:0004383)1.68085866
166Impulsivity (HP:0100710)1.66978020
167Abnormal number of incisors (HP:0011064)1.62987381
168Segmental peripheral demyelination/remyelination (HP:0003481)1.61919751
169Chest pain (HP:0100749)1.61803972
170Metaphyseal cupping (HP:0003021)1.61178189
171Abnormality of the intervertebral disk (HP:0005108)1.57102712
172Lower limb asymmetry (HP:0100559)1.55889007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.79546184
2MAP3K94.37558781
3NTRK33.91202593
4SMG13.28267139
5EPHA43.23923671
6TRIB33.08771587
7MINK12.94692011
8MAP3K42.76772917
9NTRK22.60087581
10TNK22.53194122
11IRAK42.51294428
12PAK62.40722960
13DAPK22.37913471
14MAP3K112.31196367
15NTRK12.19735598
16LATS22.17258966
17KSR22.15892700
18CAMK1D2.09587164
19MAP2K72.06885488
20MAP4K12.02021343
21PRKD31.96485242
22SIK21.84246373
23TYRO31.84041627
24MAP2K41.76873763
25MAP2K31.73372065
26GRK51.69180594
27ERN11.68646379
28KSR11.65038281
29IRAK21.58374236
30DAPK11.58347694
31CAMKK11.56814525
32MAP3K121.52340470
33CDK51.51718423
34GRK61.48117120
35PHKG11.47998983
36PHKG21.47998983
37MAPK131.47413274
38UHMK11.44775005
39PNCK1.40889271
40CDK121.39400281
41TAOK11.36062311
42PLK21.31039662
43SIK31.30579444
44ALK1.27499827
45STK381.25294956
46PRKD21.19514874
47MAP3K21.16359063
48PRKCG1.12345788
49CASK1.11191844
50RIPK41.06637641
51RET1.05309762
52VRK21.04565582
53STK111.01421568
54CDK150.99948134
55SCYL20.99934172
56CDK180.99734090
57EEF2K0.98912054
58CDK190.98744981
59SIK10.96771879
60CDK140.96704828
61CDK11A0.88851000
62HCK0.87936102
63PAK30.87264513
64CSNK1G20.86411639
65CSK0.85628827
66TYK20.84593183
67MARK20.83482153
68DYRK20.82994215
69DYRK30.82114329
70IRAK30.81401582
71BLK0.81330646
72ICK0.81122003
73PRPF4B0.79029214
74RIPK10.78034551
75FES0.77949505
76DYRK1A0.75162723
77ARAF0.74543377
78HIPK20.74186615
79EPHB10.73995983
80PTK60.72520080
81CAMK2A0.71442467
82CAMK10.67414529
83MAP3K100.66834577
84TNIK0.65524056
85TAF10.65357431
86PDGFRA0.65330587
87BRSK10.64675579
88MAP2K60.63065893
89EPHB20.60968099
90PRKCZ0.60587586
91RPS6KA20.60230552
92PRKCH0.58978052
93IRAK10.58852651
94FGR0.58682891
95CDC42BPA0.57396282
96LIMK10.57340551
97MAP3K30.57320295
98RPS6KL10.55825853
99RPS6KC10.55825853
100RAF10.55786779
101MARK30.55622332
102NEK10.55454483
103STK160.54623323
104NME10.54234737
105FGFR20.53712865
106LMTK20.53200056
107DDR20.52975047
108RPS6KA60.52444397
109FER0.50822110
110DAPK30.49092335
111RPS6KA10.47254324
112SGK2230.46905472
113SGK4940.46905472
114SGK30.46755638
115DYRK1B0.44355889
116MAPK100.44323814
117JAK20.43349769
118RPS6KA30.42597349
119MAP3K60.41919058
120SYK0.41905809
121FYN0.41688871
122SGK10.40771602
123RPS6KA40.40305989
124MAP3K10.39680238
125CSNK1G30.39576436
126CAMK2B0.39199821
127ERBB30.38223057
128BTK0.38155604
129PDK10.36402320
130BRD40.36223119
131LYN0.36007047
132CSNK1E0.35797977
133PTK2B0.35382327
134MATK0.34411370
135MAP2K20.34125626
136LRRK20.33967439
137CAMK40.33274948
138BRAF0.32568910
139MAPK120.32250899
140ADRBK20.32178092
141CAMKK20.32143760
142PRKCE0.31818980
143CAMK1G0.30801295
144CSNK1A1L0.30336389
145TAOK20.30035193
146MAPK80.29877384
147PRKCI0.29782440
148MAP3K70.29683344
149PDPK10.29290374
150ROCK20.28536206
151MAPK90.27884237

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.35689194
2Synaptic vesicle cycle_Homo sapiens_hsa047213.22274852
3Long-term potentiation_Homo sapiens_hsa047202.54873886
4Olfactory transduction_Homo sapiens_hsa047402.53403953
5GABAergic synapse_Homo sapiens_hsa047272.52350125
6Circadian entrainment_Homo sapiens_hsa047132.50494427
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42791660
8Glutamatergic synapse_Homo sapiens_hsa047242.41966514
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.41718667
10Morphine addiction_Homo sapiens_hsa050322.29148225
11Amphetamine addiction_Homo sapiens_hsa050312.18704024
12Dopaminergic synapse_Homo sapiens_hsa047282.12906007
13Sulfur relay system_Homo sapiens_hsa041222.03831397
14Salivary secretion_Homo sapiens_hsa049701.96529930
15Insulin secretion_Homo sapiens_hsa049111.92962135
16Cholinergic synapse_Homo sapiens_hsa047251.90171846
17Gastric acid secretion_Homo sapiens_hsa049711.83918516
18Acute myeloid leukemia_Homo sapiens_hsa052211.76044905
19Notch signaling pathway_Homo sapiens_hsa043301.75824164
20Osteoclast differentiation_Homo sapiens_hsa043801.75094655
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72783749
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71703350
23B cell receptor signaling pathway_Homo sapiens_hsa046621.69052077
24Long-term depression_Homo sapiens_hsa047301.68912342
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63901955
26Oxytocin signaling pathway_Homo sapiens_hsa049211.62075158
27GnRH signaling pathway_Homo sapiens_hsa049121.60225176
28Taste transduction_Homo sapiens_hsa047421.60146701
29Renin secretion_Homo sapiens_hsa049241.59126773
30Axon guidance_Homo sapiens_hsa043601.56468897
31Gap junction_Homo sapiens_hsa045401.54933519
32Serotonergic synapse_Homo sapiens_hsa047261.53604321
33Cocaine addiction_Homo sapiens_hsa050301.49845680
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48961231
35Estrogen signaling pathway_Homo sapiens_hsa049151.47777980
36Glioma_Homo sapiens_hsa052141.45169003
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.39933832
38Calcium signaling pathway_Homo sapiens_hsa040201.34029025
39Chronic myeloid leukemia_Homo sapiens_hsa052201.29366590
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26809128
41ErbB signaling pathway_Homo sapiens_hsa040121.24217205
42Melanogenesis_Homo sapiens_hsa049161.23985682
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21504936
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20805469
45Type II diabetes mellitus_Homo sapiens_hsa049301.20637390
46T cell receptor signaling pathway_Homo sapiens_hsa046601.19407648
47Leishmaniasis_Homo sapiens_hsa051401.18698487
48Ribosome_Homo sapiens_hsa030101.18493192
49Oocyte meiosis_Homo sapiens_hsa041141.17769947
50Tuberculosis_Homo sapiens_hsa051521.15394031
51cAMP signaling pathway_Homo sapiens_hsa040241.14904332
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14285032
53Collecting duct acid secretion_Homo sapiens_hsa049661.12116425
54Pancreatic cancer_Homo sapiens_hsa052121.09096626
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01347345
56Dorso-ventral axis formation_Homo sapiens_hsa043201.01013503
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.99292475
58Cardiac muscle contraction_Homo sapiens_hsa042600.97468755
59VEGF signaling pathway_Homo sapiens_hsa043700.97156648
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.95576265
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94036541
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91550353
63mTOR signaling pathway_Homo sapiens_hsa041500.90747204
64Endometrial cancer_Homo sapiens_hsa052130.90630939
65Choline metabolism in cancer_Homo sapiens_hsa052310.88682191
66Vibrio cholerae infection_Homo sapiens_hsa051100.83317726
67MAPK signaling pathway_Homo sapiens_hsa040100.82928073
68African trypanosomiasis_Homo sapiens_hsa051430.82101029
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81218814
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80927689
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79918180
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79399263
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.78828059
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76599412
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75648775
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74498271
77Colorectal cancer_Homo sapiens_hsa052100.73147187
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72767611
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71182746
80Renal cell carcinoma_Homo sapiens_hsa052110.71180109
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71133375
82Rap1 signaling pathway_Homo sapiens_hsa040150.70810909
83Non-small cell lung cancer_Homo sapiens_hsa052230.70634156
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.70106456
85Measles_Homo sapiens_hsa051620.68424545
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67847644
87Hepatitis B_Homo sapiens_hsa051610.67137659
88Ras signaling pathway_Homo sapiens_hsa040140.67113574
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66881609
90Thyroid hormone synthesis_Homo sapiens_hsa049180.66310358
91Wnt signaling pathway_Homo sapiens_hsa043100.65939826
92Dilated cardiomyopathy_Homo sapiens_hsa054140.65231889
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64531474
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64194309
95Alcoholism_Homo sapiens_hsa050340.63319020
96Pancreatic secretion_Homo sapiens_hsa049720.62697016
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62438046
98Primary immunodeficiency_Homo sapiens_hsa053400.62279839
99Regulation of autophagy_Homo sapiens_hsa041400.61539297
100Endocytosis_Homo sapiens_hsa041440.60089494
101Prion diseases_Homo sapiens_hsa050200.59795308
102Phototransduction_Homo sapiens_hsa047440.58472083
103Fatty acid biosynthesis_Homo sapiens_hsa000610.57868410
104Insulin signaling pathway_Homo sapiens_hsa049100.57709120
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.57263081
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56232002
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56110323
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.55726586
109Hepatitis C_Homo sapiens_hsa051600.55534145
110Glucagon signaling pathway_Homo sapiens_hsa049220.55349564
111FoxO signaling pathway_Homo sapiens_hsa040680.54375950
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54369885
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54354030
114Hedgehog signaling pathway_Homo sapiens_hsa043400.54228453
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54074833
116Hippo signaling pathway_Homo sapiens_hsa043900.53821278
117Phagosome_Homo sapiens_hsa041450.51637653
118AMPK signaling pathway_Homo sapiens_hsa041520.50932142
119Bladder cancer_Homo sapiens_hsa052190.48452630
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.48404105
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46337994
122Melanoma_Homo sapiens_hsa052180.40490712
123Prolactin signaling pathway_Homo sapiens_hsa049170.40011299
124Tight junction_Homo sapiens_hsa045300.39162555
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37965780
126Type I diabetes mellitus_Homo sapiens_hsa049400.36006779
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34774214
128Basal cell carcinoma_Homo sapiens_hsa052170.33871963
129Inositol phosphate metabolism_Homo sapiens_hsa005620.32207049
130Chemokine signaling pathway_Homo sapiens_hsa040620.31623540
131Bile secretion_Homo sapiens_hsa049760.30531997
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30140609

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