LRFN5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the leucine-rich repeat and fibronectin type III domain-containing family of proteins. A similar protein in mouse, a glycosylated transmembrane protein, is thought to function in presynaptic differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.76920685
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.62212635
3neuron cell-cell adhesion (GO:0007158)5.58345678
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.57129962
5protein localization to synapse (GO:0035418)5.28832643
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28269661
7ionotropic glutamate receptor signaling pathway (GO:0035235)5.24306052
8regulation of glutamate receptor signaling pathway (GO:1900449)5.14311411
9synaptic vesicle exocytosis (GO:0016079)5.08973926
10pyrimidine nucleobase catabolic process (GO:0006208)5.07987452
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.93903829
12glutamate receptor signaling pathway (GO:0007215)4.88996928
13glutamate secretion (GO:0014047)4.67139252
14locomotory exploration behavior (GO:0035641)4.62016589
15synaptic transmission, glutamatergic (GO:0035249)4.58503292
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56067471
17regulation of synaptic vesicle exocytosis (GO:2000300)4.51870437
18neuron-neuron synaptic transmission (GO:0007270)4.43704045
19presynaptic membrane assembly (GO:0097105)4.38481599
20neuronal action potential propagation (GO:0019227)4.37610261
21neuron recognition (GO:0008038)4.34637107
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.32149386
23exploration behavior (GO:0035640)4.32056037
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.29536538
25synaptic vesicle maturation (GO:0016188)4.29206154
26neurotransmitter-gated ion channel clustering (GO:0072578)4.21546261
27nucleobase catabolic process (GO:0046113)4.18203447
28postsynaptic membrane organization (GO:0001941)4.13039902
29negative regulation of synaptic transmission, GABAergic (GO:0032229)4.12463188
30regulation of synaptic vesicle transport (GO:1902803)4.12303905
31regulation of long-term neuronal synaptic plasticity (GO:0048169)4.08659036
32presynaptic membrane organization (GO:0097090)4.03262576
33regulation of excitatory postsynaptic membrane potential (GO:0060079)3.93799916
34neurotransmitter secretion (GO:0007269)3.91081008
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.90605774
36regulation of neuronal synaptic plasticity (GO:0048168)3.89964442
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.89106517
38positive regulation of synapse maturation (GO:0090129)3.86604932
39axonal fasciculation (GO:0007413)3.83801198
40regulation of postsynaptic membrane potential (GO:0060078)3.83238606
41response to histamine (GO:0034776)3.80076842
42long-term memory (GO:0007616)3.71580578
43establishment of mitochondrion localization (GO:0051654)3.68673293
44regulation of synaptic transmission, glutamatergic (GO:0051966)3.65352581
45startle response (GO:0001964)3.64499170
46transmission of nerve impulse (GO:0019226)3.63990907
47positive regulation of membrane potential (GO:0045838)3.62256821
48proline transport (GO:0015824)3.59841398
49dendritic spine morphogenesis (GO:0060997)3.59608935
50layer formation in cerebral cortex (GO:0021819)3.58264588
51gamma-aminobutyric acid transport (GO:0015812)3.56769544
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.52553095
53cell migration in hindbrain (GO:0021535)3.52138159
54behavioral fear response (GO:0001662)3.47386955
55behavioral defense response (GO:0002209)3.47386955
56long-term synaptic potentiation (GO:0060291)3.47355594
57regulation of synapse structural plasticity (GO:0051823)3.46193591
58regulation of synaptic plasticity (GO:0048167)3.42725534
59regulation of dendritic spine morphogenesis (GO:0061001)3.42263238
60positive regulation of neurotransmitter secretion (GO:0001956)3.41385700
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.41312029
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.41135562
63regulation of glutamate secretion (GO:0014048)3.38174685
64glycosphingolipid biosynthetic process (GO:0006688)3.38091660
65mechanosensory behavior (GO:0007638)3.36274906
66synaptic vesicle endocytosis (GO:0048488)3.34940762
67regulation of synapse maturation (GO:0090128)3.33758005
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.33694003
69neurotransmitter transport (GO:0006836)3.33272032
70positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.33074718
71positive regulation of synapse assembly (GO:0051965)3.32747160
72neurofilament cytoskeleton organization (GO:0060052)3.31799580
73synapse assembly (GO:0007416)3.29552457
74membrane depolarization (GO:0051899)3.28369735
75fear response (GO:0042596)3.27908709
76regulation of neurotransmitter secretion (GO:0046928)3.26516548
77regulation of vesicle fusion (GO:0031338)3.24659448
78sodium ion export (GO:0071436)3.15191601
79learning (GO:0007612)3.15189549
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14674221
81membrane depolarization during action potential (GO:0086010)3.14551321
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.13425711
83regulation of dendritic spine development (GO:0060998)3.13379979
84innervation (GO:0060384)3.13204877
85membrane hyperpolarization (GO:0060081)3.12353176
86serotonin metabolic process (GO:0042428)3.08505757
87synaptic transmission (GO:0007268)3.06395096
88positive regulation of neurotransmitter transport (GO:0051590)3.05703858
89neuronal ion channel clustering (GO:0045161)3.05627555
90C4-dicarboxylate transport (GO:0015740)3.04692829
91regulation of neurotransmitter levels (GO:0001505)3.04019419
92central nervous system projection neuron axonogenesis (GO:0021952)3.03630078
93behavioral response to cocaine (GO:0048148)3.02260536
94positive regulation of dendritic spine morphogenesis (GO:0061003)3.01640714
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.01298336
96negative regulation of amino acid transport (GO:0051956)3.01166861
97G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99333379
98cellular potassium ion homeostasis (GO:0030007)2.98861006
99positive regulation of dendritic spine development (GO:0060999)2.98468749
100regulation of synaptic transmission (GO:0050804)2.96439979
101cerebellar granule cell differentiation (GO:0021707)2.94972698
102regulation of synaptic transmission, GABAergic (GO:0032228)2.94177639
103regulation of neurotransmitter transport (GO:0051588)2.93986513
104cochlea development (GO:0090102)2.93789666
105cerebellar Purkinje cell differentiation (GO:0021702)2.92981358
106neuromuscular synaptic transmission (GO:0007274)2.90526019
107positive regulation of synaptic transmission (GO:0050806)2.90388975
108regulation of synapse assembly (GO:0051963)2.90230100
109social behavior (GO:0035176)2.90201981
110intraspecies interaction between organisms (GO:0051703)2.90201981
111establishment of synaptic vesicle localization (GO:0097480)2.89585670
112synaptic vesicle transport (GO:0048489)2.89585670
113regulation of voltage-gated calcium channel activity (GO:1901385)2.88985064
114auditory behavior (GO:0031223)2.88540053
115righting reflex (GO:0060013)2.88491736
116synapse organization (GO:0050808)2.87818509
117dendrite morphogenesis (GO:0048813)2.87723064
118short-term memory (GO:0007614)2.85929028
119response to auditory stimulus (GO:0010996)2.85708996
120positive regulation of potassium ion transmembrane transport (GO:1901381)2.83075924
121adult walking behavior (GO:0007628)2.81361458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.41164053
2GBX2_23144817_ChIP-Seq_PC3_Human4.36316954
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12265576
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08089375
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99520551
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65551882
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56631634
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56631634
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54067893
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53588178
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.53558530
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.52432461
13TAF15_26573619_Chip-Seq_HEK293_Human2.50383662
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43696838
15* EED_16625203_ChIP-ChIP_MESCs_Mouse2.36446606
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33590337
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30611585
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22362756
19* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19790359
20* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14080636
21* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10573056
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07441050
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.05848977
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.04423859
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.95626126
26DROSHA_22980978_ChIP-Seq_HELA_Human1.95491674
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.93815683
28AR_21572438_ChIP-Seq_LNCaP_Human1.88239164
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86797214
30P300_19829295_ChIP-Seq_ESCs_Human1.85453810
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85231449
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83332128
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.83048463
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82090137
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81509041
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79240275
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78833368
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76268871
39* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73817363
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71169472
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65713502
42* CBX2_27304074_Chip-Seq_ESCs_Mouse1.64760869
43FUS_26573619_Chip-Seq_HEK293_Human1.59832827
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.51985663
45IGF1R_20145208_ChIP-Seq_DFB_Human1.48786845
46* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48699254
47* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48669195
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.46649310
49VDR_22108803_ChIP-Seq_LS180_Human1.45958699
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.45537028
51* AR_25329375_ChIP-Seq_VCAP_Human1.43480709
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42474498
53* RNF2_27304074_Chip-Seq_NSC_Mouse1.41868024
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41681051
55* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39446584
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36561668
57* ZNF274_21170338_ChIP-Seq_K562_Hela1.35079406
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34949532
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.32440267
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31100589
61* STAT3_23295773_ChIP-Seq_U87_Human1.30162240
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29586093
63* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26108491
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24432355
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24215670
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19537465
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19259584
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17991655
69LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17913447
70TCF4_23295773_ChIP-Seq_U87_Human1.17766507
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17660901
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16290497
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.16222690
74JUN_21703547_ChIP-Seq_K562_Human1.15790534
75* ARNT_22903824_ChIP-Seq_MCF-7_Human1.15430806
76* RING1B_27294783_Chip-Seq_ESCs_Mouse1.15034018
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14966316
78* RUNX2_22187159_ChIP-Seq_PCA_Human1.14559485
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.14090512
80CBP_20019798_ChIP-Seq_JUKART_Human1.12931945
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12931945
82* ER_23166858_ChIP-Seq_MCF-7_Human1.12658055
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12472106
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12257185
85TP53_18474530_ChIP-ChIP_U2OS_Human1.12193429
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10713290
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10616865
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10616865
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10334375
90AR_19668381_ChIP-Seq_PC3_Human1.09095808
91* TAL1_26923725_Chip-Seq_HPCs_Mouse1.08545354
92* ERG_21242973_ChIP-ChIP_JURKAT_Human1.08023942
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05644702
94GATA1_26923725_Chip-Seq_HPCs_Mouse1.04974410
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03975172
96* AHR_22903824_ChIP-Seq_MCF-7_Human1.03878529
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03078070
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01799397
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00894203
100* SOX9_26525672_Chip-Seq_HEART_Mouse1.00724683
101* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00618474
102TP53_16413492_ChIP-PET_HCT116_Human1.00457301
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00314184
104BCAT_22108803_ChIP-Seq_LS180_Human0.99619998
105E2F1_18555785_Chip-Seq_ESCs_Mouse0.98994099
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98272572
107KDM2B_26808549_Chip-Seq_REH_Human0.98035332
108EWS_26573619_Chip-Seq_HEK293_Human0.97847669
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97620729
110FLI1_27457419_Chip-Seq_LIVER_Mouse0.96243359
111* RING1B_27294783_Chip-Seq_NPCs_Mouse0.95676660
112* FLI1_21867929_ChIP-Seq_TH2_Mouse0.95460708
113RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94327872
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92866448
115CMYC_18555785_Chip-Seq_ESCs_Mouse0.92561129
116P53_22387025_ChIP-Seq_ESCs_Mouse0.92502430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.75346279
2MP0003880_abnormal_central_pattern5.63887446
3MP0003635_abnormal_synaptic_transmissio4.02999150
4MP0001968_abnormal_touch/_nociception3.61347016
5MP0009745_abnormal_behavioral_response3.52824453
6MP0004270_analgesia3.47191145
7MP0002063_abnormal_learning/memory/cond3.28386114
8MP0002064_seizures3.13078876
9MP0002735_abnormal_chemical_nociception3.06454356
10MP0002736_abnormal_nociception_after3.03370884
11MP0009046_muscle_twitch3.01651991
12MP0002572_abnormal_emotion/affect_behav2.93782079
13MP0002734_abnormal_mechanical_nocicepti2.66339693
14MP0002272_abnormal_nervous_system2.64971505
15MP0005423_abnormal_somatic_nervous2.62567188
16MP0001486_abnormal_startle_reflex2.56136734
17MP0001501_abnormal_sleep_pattern2.48833971
18MP0006276_abnormal_autonomic_nervous2.46147972
19MP0001440_abnormal_grooming_behavior2.43018631
20MP0002733_abnormal_thermal_nociception2.25343041
21MP0002067_abnormal_sensory_capabilities2.18569486
22MP0001970_abnormal_pain_threshold2.09667767
23MP0002822_catalepsy2.04867346
24MP0002184_abnormal_innervation1.99826589
25MP0000778_abnormal_nervous_system1.97848258
26MP0001188_hyperpigmentation1.89300517
27MP0002557_abnormal_social/conspecific_i1.82039846
28MP0004924_abnormal_behavior1.74845093
29MP0005386_behavior/neurological_phenoty1.74845093
30MP0001529_abnormal_vocalization1.67807620
31MP0003787_abnormal_imprinting1.66177523
32MP0003879_abnormal_hair_cell1.64042942
33MP0001984_abnormal_olfaction1.57376361
34MP0009780_abnormal_chondrocyte_physiolo1.56490796
35MP0005645_abnormal_hypothalamus_physiol1.55046966
36MP0004811_abnormal_neuron_physiology1.54436339
37MP0005646_abnormal_pituitary_gland1.53758470
38MP0003329_amyloid_beta_deposits1.53660233
39MP0004858_abnormal_nervous_system1.52907757
40MP0008569_lethality_at_weaning1.46638441
41MP0001905_abnormal_dopamine_level1.45097463
42MP0000955_abnormal_spinal_cord1.43689923
43MP0004142_abnormal_muscle_tone1.38139197
44MP0002066_abnormal_motor_capabilities/c1.37108347
45MP0002882_abnormal_neuron_morphology1.36106729
46MP0001502_abnormal_circadian_rhythm1.34281637
47MP0003122_maternal_imprinting1.31001617
48MP0005187_abnormal_penis_morphology1.23538195
49MP0002837_dystrophic_cardiac_calcinosis1.20313385
50MP0002876_abnormal_thyroid_physiology1.18751314
51MP0008877_abnormal_DNA_methylation1.18431809
52MP0004742_abnormal_vestibular_system1.15168027
53MP0002909_abnormal_adrenal_gland1.14996877
54MP0003633_abnormal_nervous_system1.11005349
55MP0004885_abnormal_endolymph1.03701097
56MP0002152_abnormal_brain_morphology1.03302729
57MP0010386_abnormal_urinary_bladder1.02664036
58MP0001299_abnormal_eye_distance/0.99078507
59MP0005409_darkened_coat_color0.98692636
60MP0003631_nervous_system_phenotype0.97261979
61MP0001963_abnormal_hearing_physiology0.97172642
62MP0004147_increased_porphyrin_level0.93683633
63MP0005551_abnormal_eye_electrophysiolog0.93645947
64MP0000751_myopathy0.90849061
65MP0002229_neurodegeneration0.90592182
66MP0004133_heterotaxia0.88748745
67MP0002069_abnormal_eating/drinking_beha0.88550673
68MP0004145_abnormal_muscle_electrophysio0.87948210
69MP0005253_abnormal_eye_physiology0.85783466
70MP0008872_abnormal_physiological_respon0.84544779
71MP0006072_abnormal_retinal_apoptosis0.84268834
72MP0002752_abnormal_somatic_nervous0.84260139
73MP0004085_abnormal_heartbeat0.82550452
74MP0008874_decreased_physiological_sensi0.82124652
75MP0004484_altered_response_of0.82029116
76MP0003890_abnormal_embryonic-extraembry0.81426938
77MP0002234_abnormal_pharynx_morphology0.81356215
78MP0006292_abnormal_olfactory_placode0.79601319
79MP0000631_abnormal_neuroendocrine_gland0.79395092
80MP0005171_absent_coat_pigmentation0.77557638
81MP0005535_abnormal_body_temperature0.76948499
82MP0002102_abnormal_ear_morphology0.76211337
83MP0005394_taste/olfaction_phenotype0.75819782
84MP0005499_abnormal_olfactory_system0.75819782
85MP0004215_abnormal_myocardial_fiber0.73707386
86MP0001664_abnormal_digestion0.72603260
87MP0000026_abnormal_inner_ear0.69958118
88MP0003119_abnormal_digestive_system0.69092097
89MP0001485_abnormal_pinna_reflex0.68750341
90MP0002638_abnormal_pupillary_reflex0.68363500
91MP0003634_abnormal_glial_cell0.65903908
92MP0001177_atelectasis0.65206020
93MP0004510_myositis0.64901878
94MP0003632_abnormal_nervous_system0.64442847
95MP0003385_abnormal_body_wall0.61321711
96MP0000049_abnormal_middle_ear0.61206621
97MP0000604_amyloidosis0.60190249
98MP0005195_abnormal_posterior_eye0.59777424
99MP0000569_abnormal_digit_pigmentation0.58218733
100MP0010768_mortality/aging0.56030051
101MP0003121_genomic_imprinting0.54167062
102MP0003137_abnormal_impulse_conducting0.53315052
103MP0003861_abnormal_nervous_system0.52872711
104MP0001986_abnormal_taste_sensitivity0.52810961
105MP0009379_abnormal_foot_pigmentation0.52164045
106MP0001943_abnormal_respiration0.52070309
107MP0002751_abnormal_autonomic_nervous0.50876481
108MP0010770_preweaning_lethality0.50519730
109MP0002082_postnatal_lethality0.50519730
110MP0005379_endocrine/exocrine_gland_phen0.50478096
111MP0002090_abnormal_vision0.50434213
112MP0000920_abnormal_myelination0.50404770
113MP0010769_abnormal_survival0.48803025
114MP0000015_abnormal_ear_pigmentation0.48679645

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.75880743
2Focal seizures (HP:0007359)6.00647570
3Myokymia (HP:0002411)5.85364683
4Epileptic encephalopathy (HP:0200134)5.60948041
5Atonic seizures (HP:0010819)5.52115975
6Febrile seizures (HP:0002373)5.37946764
7Visual hallucinations (HP:0002367)4.86836383
8Absence seizures (HP:0002121)4.70760294
9Hyperventilation (HP:0002883)4.60022238
10Dialeptic seizures (HP:0011146)4.41063362
11Progressive cerebellar ataxia (HP:0002073)4.27633628
12Generalized tonic-clonic seizures (HP:0002069)4.12107511
13Broad-based gait (HP:0002136)4.02858089
14Drooling (HP:0002307)3.37424687
15Excessive salivation (HP:0003781)3.37424687
16Amblyopia (HP:0000646)3.28866580
17Gaze-evoked nystagmus (HP:0000640)3.24356710
18Poor eye contact (HP:0000817)3.17189617
19Truncal ataxia (HP:0002078)3.00939491
20Supranuclear gaze palsy (HP:0000605)2.99771436
21Protruding tongue (HP:0010808)2.85428256
22Absent speech (HP:0001344)2.85275299
23Action tremor (HP:0002345)2.84820770
24Progressive inability to walk (HP:0002505)2.82554939
25Inability to walk (HP:0002540)2.81525317
26Epileptiform EEG discharges (HP:0011182)2.80753288
27Abnormal social behavior (HP:0012433)2.78884960
28Impaired social interactions (HP:0000735)2.78884960
29Dysdiadochokinesis (HP:0002075)2.77325022
30Impaired vibration sensation in the lower limbs (HP:0002166)2.75453404
31Abnormal eating behavior (HP:0100738)2.74607439
32Polyphagia (HP:0002591)2.73042198
33Abnormality of binocular vision (HP:0011514)2.71349231
34Diplopia (HP:0000651)2.71349231
35Mutism (HP:0002300)2.70958306
36Limb dystonia (HP:0002451)2.68487610
37Dysmetria (HP:0001310)2.68447923
38Anxiety (HP:0000739)2.66148187
39Hemiparesis (HP:0001269)2.66005924
40Urinary bladder sphincter dysfunction (HP:0002839)2.59568133
41Fetal akinesia sequence (HP:0001989)2.57846127
42Cerebral inclusion bodies (HP:0100314)2.56317083
43EEG with generalized epileptiform discharges (HP:0011198)2.55020005
44Gait imbalance (HP:0002141)2.46356181
45Morphological abnormality of the pyramidal tract (HP:0002062)2.44758122
46Spastic tetraplegia (HP:0002510)2.42705628
47Neurofibrillary tangles (HP:0002185)2.40873035
48Abnormality of the labia minora (HP:0012880)2.40775685
49Depression (HP:0000716)2.39872387
50Insidious onset (HP:0003587)2.39493286
51Termporal pattern (HP:0011008)2.39493286
52Ulnar claw (HP:0001178)2.36961850
53Abnormality of salivation (HP:0100755)2.36928724
54Abnormality of the corticospinal tract (HP:0002492)2.36413628
55Agnosia (HP:0010524)2.36382998
56Ankle clonus (HP:0011448)2.34854053
57Hypsarrhythmia (HP:0002521)2.34180343
58Absent/shortened dynein arms (HP:0200106)2.32974162
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.32974162
60Blue irides (HP:0000635)2.32433493
61Abnormal hair whorl (HP:0010721)2.31630435
62Impaired smooth pursuit (HP:0007772)2.29883189
63Genital tract atresia (HP:0001827)2.28255855
64Scanning speech (HP:0002168)2.27396168
65Genetic anticipation (HP:0003743)2.26108322
66Urinary urgency (HP:0000012)2.24558259
67Vaginal atresia (HP:0000148)2.24052370
68Abnormality of the astrocytes (HP:0100707)2.23621146
69Astrocytoma (HP:0009592)2.23621146
70Stereotypic behavior (HP:0000733)2.22404559
71Lissencephaly (HP:0001339)2.21918133
72Retinal dysplasia (HP:0007973)2.19192312
73Hepatoblastoma (HP:0002884)2.18403624
74Generalized myoclonic seizures (HP:0002123)2.16446379
75Postural instability (HP:0002172)2.16367055
76Inappropriate behavior (HP:0000719)2.15572903
77Bradykinesia (HP:0002067)2.14620328
78Spastic gait (HP:0002064)2.12988138
79Sleep apnea (HP:0010535)2.11081085
80Abnormality of the lower motor neuron (HP:0002366)2.09852318
81Status epilepticus (HP:0002133)2.09761168
82Intention tremor (HP:0002080)2.04649696
83Pheochromocytoma (HP:0002666)2.02470091
84Akinesia (HP:0002304)2.02384775
85Fair hair (HP:0002286)2.01834662
86Medial flaring of the eyebrow (HP:0010747)2.00320190
87Amyotrophic lateral sclerosis (HP:0007354)2.00306054
88Failure to thrive in infancy (HP:0001531)1.99191182
89Abnormality of ocular smooth pursuit (HP:0000617)1.98591728
90Torticollis (HP:0000473)1.96457066
91Congenital primary aphakia (HP:0007707)1.96348447
92Abnormal ciliary motility (HP:0012262)1.95036536
93Esotropia (HP:0000565)1.94870973
94Papilledema (HP:0001085)1.94029451
95Generalized hypopigmentation of hair (HP:0011358)1.93697973
96Specific learning disability (HP:0001328)1.93047813
97Medulloblastoma (HP:0002885)1.92305235
98Agitation (HP:0000713)1.90547063
99Exotropia (HP:0000577)1.89584529
100Psychosis (HP:0000709)1.88174571
101Widely spaced teeth (HP:0000687)1.87932859
102Nephrogenic diabetes insipidus (HP:0009806)1.87519722
103Neuroendocrine neoplasm (HP:0100634)1.87414714
104Delusions (HP:0000746)1.86323597
105Focal dystonia (HP:0004373)1.86111245
106Hypoplasia of the brainstem (HP:0002365)1.85324358
107Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85324358
108Impaired vibratory sensation (HP:0002495)1.84902228
109Hypoplasia of the corpus callosum (HP:0002079)1.84523802
110Incomplete penetrance (HP:0003829)1.84396007
111Morphological abnormality of the middle ear (HP:0008609)1.83682228
112Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83152509
113Lower limb muscle weakness (HP:0007340)1.82793029
114Gait ataxia (HP:0002066)1.82703707
115Acute necrotizing encephalopathy (HP:0006965)1.82509930
116Lower limb amyotrophy (HP:0007210)1.81036473
117Paraplegia (HP:0010550)1.81026162
118Cutaneous finger syndactyly (HP:0010554)1.80822421
119Hemiplegia (HP:0002301)1.80701405
120Degeneration of the lateral corticospinal tracts (HP:0002314)1.79649656
121Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79649656
122Dyskinesia (HP:0100660)1.78746122
123Pachygyria (HP:0001302)1.77534123
124Nephronophthisis (HP:0000090)1.76440417
125Cortical dysplasia (HP:0002539)1.72477262
126Poor suck (HP:0002033)1.72353833
127Poor coordination (HP:0002370)1.71675802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.84728884
2EPHA44.48859770
3CASK3.81468128
4MARK13.35738688
5MAP2K73.24216995
6MAP3K43.21163324
7MAP3K92.91119991
8MAP3K122.76613872
9RIPK42.50905879
10MINK12.45687851
11MAP4K22.32663714
12TNIK2.24765177
13DAPK22.17658227
14NTRK22.09911538
15MAP2K42.07303334
16PNCK1.98070191
17PLK21.88886469
18MAPK131.76279092
19SIK21.75975059
20DAPK11.65307381
21GRK51.64528474
22CSNK1G31.60796949
23CSNK1A1L1.53827011
24PAK61.49951971
25CSNK1G11.40662837
26KSR11.37913923
27NTRK11.37751647
28CDK51.35709198
29CDK191.31449406
30PRPF4B1.27585087
31TRIM281.27202302
32KSR21.25180601
33FES1.24794240
34PRKCG1.22259516
35CAMK2A1.21083514
36BMPR21.21047579
37FRK1.18087308
38CAMK2B1.06735481
39SIK31.02918505
40CAMKK11.02622444
41INSRR1.01340517
42ARAF1.00739656
43GRK70.97879306
44CAMKK20.94592591
45CAMK40.91862900
46LATS20.90619780
47CCNB10.90057070
48PHKG10.89276212
49PHKG20.89276212
50NME10.88098515
51PTK2B0.85118332
52OXSR10.84975089
53MAP3K60.84723214
54UHMK10.84580762
55MAP3K130.80685478
56AKT30.77687403
57STK380.75064685
58FGR0.74754495
59PRKCE0.74521690
60CAMK10.72382486
61SGK4940.72144619
62SGK2230.72144619
63CDK180.72014603
64SGK20.71711606
65CSNK1G20.71696800
66DYRK1A0.71188514
67ADRBK20.69548546
68CDK140.68627887
69MUSK0.68031005
70CDK150.67658068
71SGK10.67475466
72MAP3K20.65536925
73TAOK10.63728441
74STK110.63059031
75MARK20.62009635
76BMPR1B0.60290953
77FER0.58412761
78PAK30.58389628
79CDK11A0.58090025
80RAF10.58057132
81CAMK2D0.57744010
82TSSK60.54331412
83MAPK120.54243820
84RET0.52806534
85BRD40.51979838
86CSNK1D0.50928226
87PRKD30.50305331
88MKNK20.49151876
89LIMK10.46662360
90ADRBK10.46405642
91BCR0.46270594
92WNK30.46248183
93CAMK1G0.46211791
94TNK20.45834424
95ERBB30.44461372
96PRKCZ0.44148383
97CAMK2G0.44102828
98MAP3K50.41384409
99CSNK1E0.40368192
100DYRK30.39906494
101CSNK1A10.39623897
102PRKACB0.39149644
103PKN10.38058936
104RPS6KA30.35704090
105FYN0.35260248
106PRKACA0.35214636
107NEK60.34173279
108MAP2K10.33891797
109SGK30.33231083
110PINK10.33177210
111BRAF0.31975030
112PRKCB0.31614327
113PRKG10.31564951
114TYRO30.31448725
115MAPK100.30984742
116PDK10.30834579
117DYRK20.29733204
118PRKCA0.29133061
119ROCK20.29118845
120PDPK10.29051662
121PRKCH0.28964063
122MAPK90.28644805
123GRK10.28521494
124GSK3B0.27190967

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.63308841
2Synaptic vesicle cycle_Homo sapiens_hsa047213.20718797
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.07029651
4Long-term potentiation_Homo sapiens_hsa047202.78657127
5GABAergic synapse_Homo sapiens_hsa047272.75568275
6Circadian entrainment_Homo sapiens_hsa047132.73036598
7Glutamatergic synapse_Homo sapiens_hsa047242.70408716
8Morphine addiction_Homo sapiens_hsa050322.67131151
9Amphetamine addiction_Homo sapiens_hsa050312.48881090
10Olfactory transduction_Homo sapiens_hsa047402.47160828
11Taste transduction_Homo sapiens_hsa047422.26776763
12Dopaminergic synapse_Homo sapiens_hsa047282.19232998
13Salivary secretion_Homo sapiens_hsa049702.15168571
14Collecting duct acid secretion_Homo sapiens_hsa049662.03057760
15Serotonergic synapse_Homo sapiens_hsa047262.00772352
16Long-term depression_Homo sapiens_hsa047301.88524979
17Insulin secretion_Homo sapiens_hsa049111.84551127
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83481778
19Renin secretion_Homo sapiens_hsa049241.82317169
20Cholinergic synapse_Homo sapiens_hsa047251.79118113
21Calcium signaling pathway_Homo sapiens_hsa040201.73921735
22Gastric acid secretion_Homo sapiens_hsa049711.67854600
23Oxytocin signaling pathway_Homo sapiens_hsa049211.62208663
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61503674
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56887673
26Cocaine addiction_Homo sapiens_hsa050301.52479219
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46852072
28GnRH signaling pathway_Homo sapiens_hsa049121.32804178
29Axon guidance_Homo sapiens_hsa043601.31208254
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29647918
31Oxidative phosphorylation_Homo sapiens_hsa001901.29207849
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28219220
33Cardiac muscle contraction_Homo sapiens_hsa042601.27798147
34Gap junction_Homo sapiens_hsa045401.24508042
35cAMP signaling pathway_Homo sapiens_hsa040241.20675379
36Alzheimers disease_Homo sapiens_hsa050101.16092608
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15730808
38Vibrio cholerae infection_Homo sapiens_hsa051101.14448945
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12933836
40Phototransduction_Homo sapiens_hsa047441.06788979
41Estrogen signaling pathway_Homo sapiens_hsa049151.03715759
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01295239
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99866912
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97863892
45ErbB signaling pathway_Homo sapiens_hsa040120.97048164
46Type II diabetes mellitus_Homo sapiens_hsa049300.95176265
47Melanogenesis_Homo sapiens_hsa049160.94425554
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94224739
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91108142
50Butanoate metabolism_Homo sapiens_hsa006500.90738761
51Glioma_Homo sapiens_hsa052140.89106186
52Parkinsons disease_Homo sapiens_hsa050120.87991093
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.87130615
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85555215
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84940192
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80807463
57Pancreatic secretion_Homo sapiens_hsa049720.75390940
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74491831
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73355337
60Oocyte meiosis_Homo sapiens_hsa041140.71044691
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70786088
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70494138
63Dorso-ventral axis formation_Homo sapiens_hsa043200.70360132
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70256293
65MAPK signaling pathway_Homo sapiens_hsa040100.67097637
66Huntingtons disease_Homo sapiens_hsa050160.66911752
67Choline metabolism in cancer_Homo sapiens_hsa052310.65852594
68Dilated cardiomyopathy_Homo sapiens_hsa054140.63523184
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.63015689
70Ras signaling pathway_Homo sapiens_hsa040140.61303917
71African trypanosomiasis_Homo sapiens_hsa051430.60240179
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59335623
73Thyroid hormone synthesis_Homo sapiens_hsa049180.57937011
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57282678
75Fatty acid biosynthesis_Homo sapiens_hsa000610.56468717
76Rheumatoid arthritis_Homo sapiens_hsa053230.54979502
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.54389758
78Type I diabetes mellitus_Homo sapiens_hsa049400.53097827
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52256743
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51277090
81Regulation of autophagy_Homo sapiens_hsa041400.50850606
82Vitamin B6 metabolism_Homo sapiens_hsa007500.50216712
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49878688
84Bile secretion_Homo sapiens_hsa049760.49855749
85Ether lipid metabolism_Homo sapiens_hsa005650.48627997
86Arginine biosynthesis_Homo sapiens_hsa002200.48115149
87Circadian rhythm_Homo sapiens_hsa047100.47297719
88Rap1 signaling pathway_Homo sapiens_hsa040150.47272584
89Glucagon signaling pathway_Homo sapiens_hsa049220.46977282
90Hippo signaling pathway_Homo sapiens_hsa043900.45686214
91VEGF signaling pathway_Homo sapiens_hsa043700.44388793
92Tight junction_Homo sapiens_hsa045300.43529442
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.43244210
94Wnt signaling pathway_Homo sapiens_hsa043100.42433614
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41775006
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.41414776
97Alcoholism_Homo sapiens_hsa050340.41000152
98Inositol phosphate metabolism_Homo sapiens_hsa005620.39516277
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36475567
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35330561
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34315543
102Protein export_Homo sapiens_hsa030600.34070798
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33993346
104Phagosome_Homo sapiens_hsa041450.33717837
105Ovarian steroidogenesis_Homo sapiens_hsa049130.33549004
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32715957
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31235523
108Hedgehog signaling pathway_Homo sapiens_hsa043400.30689989
109beta-Alanine metabolism_Homo sapiens_hsa004100.30120387
110Prion diseases_Homo sapiens_hsa050200.29265884
111Renal cell carcinoma_Homo sapiens_hsa052110.28266960
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27826732
113AMPK signaling pathway_Homo sapiens_hsa041520.27032775
114Phenylalanine metabolism_Homo sapiens_hsa003600.25646915
115Steroid biosynthesis_Homo sapiens_hsa001000.25484022
116Linoleic acid metabolism_Homo sapiens_hsa005910.24926746
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23652757
118Insulin signaling pathway_Homo sapiens_hsa049100.23637011
119Melanoma_Homo sapiens_hsa052180.22787113
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22502371
121Chemokine signaling pathway_Homo sapiens_hsa040620.20408156
122Endometrial cancer_Homo sapiens_hsa052130.19870947
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.18998469

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