LRG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.68278622
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.68278622
3L-phenylalanine metabolic process (GO:0006558)6.44832099
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.44832099
5complement activation, alternative pathway (GO:0006957)6.09566440
6aromatic amino acid family catabolic process (GO:0009074)5.94187174
7regulation of protein activation cascade (GO:2000257)5.81114986
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.80421159
9negative regulation of fibrinolysis (GO:0051918)5.78969697
10epoxygenase P450 pathway (GO:0019373)5.73552042
11omega-hydroxylase P450 pathway (GO:0097267)5.60325909
12regulation of complement activation (GO:0030449)5.49847208
13protein carboxylation (GO:0018214)5.44103649
14peptidyl-glutamic acid carboxylation (GO:0017187)5.44103649
15regulation of fibrinolysis (GO:0051917)5.38757215
16tryptophan catabolic process (GO:0006569)5.34664899
17indole-containing compound catabolic process (GO:0042436)5.34664899
18indolalkylamine catabolic process (GO:0046218)5.34664899
19urea cycle (GO:0000050)5.33565041
20urea metabolic process (GO:0019627)5.33565041
21kynurenine metabolic process (GO:0070189)5.25124827
22high-density lipoprotein particle remodeling (GO:0034375)5.24438559
23bile acid biosynthetic process (GO:0006699)5.21923974
24alpha-linolenic acid metabolic process (GO:0036109)5.13635268
25glyoxylate metabolic process (GO:0046487)5.12757905
26disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.00487379
27killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.00487379
28tryptophan metabolic process (GO:0006568)5.00484453
29regulation of triglyceride catabolic process (GO:0010896)4.93653462
30sulfur amino acid catabolic process (GO:0000098)4.92331002
31nitrogen cycle metabolic process (GO:0071941)4.90017106
32reverse cholesterol transport (GO:0043691)4.71146375
33cysteine metabolic process (GO:0006534)4.70733417
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.69837483
35plasma lipoprotein particle remodeling (GO:0034369)4.51144563
36protein-lipid complex remodeling (GO:0034368)4.51144563
37macromolecular complex remodeling (GO:0034367)4.51144563
38triglyceride homeostasis (GO:0070328)4.49882886
39acylglycerol homeostasis (GO:0055090)4.49882886
40bile acid metabolic process (GO:0008206)4.44229298
41serine family amino acid catabolic process (GO:0009071)4.39486707
42regulation of cholesterol esterification (GO:0010872)4.39420061
43regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.36596484
44plasma lipoprotein particle clearance (GO:0034381)4.32574954
45phospholipid efflux (GO:0033700)4.27769887
46aromatic amino acid family metabolic process (GO:0009072)4.26472835
47acute-phase response (GO:0006953)4.24188113
48tyrosine metabolic process (GO:0006570)4.22216400
49detection of molecule of bacterial origin (GO:0032490)4.20716309
50leukocyte migration involved in inflammatory response (GO:0002523)4.18301853
51protein activation cascade (GO:0072376)4.17011415
52homocysteine metabolic process (GO:0050667)4.16457538
53lysine catabolic process (GO:0006554)4.10116840
54lysine metabolic process (GO:0006553)4.10116840
55complement activation (GO:0006956)4.07752029
56amino-acid betaine metabolic process (GO:0006577)4.06748973
57fibrinolysis (GO:0042730)4.06192252
58alpha-amino acid catabolic process (GO:1901606)4.04142120
59drug metabolic process (GO:0017144)4.03152665
60complement activation, classical pathway (GO:0006958)4.00018211
61opsonization (GO:0008228)3.99576097
62detection of other organism (GO:0098543)3.96485068
63detection of external biotic stimulus (GO:0098581)3.95464739
64negative regulation of cholesterol transport (GO:0032375)3.92286313
65negative regulation of sterol transport (GO:0032372)3.92286313
66coenzyme catabolic process (GO:0009109)3.90152684
67positive regulation of triglyceride lipase activity (GO:0061365)3.89701388
68positive regulation of lipoprotein lipase activity (GO:0051006)3.89701388
69detection of bacterium (GO:0016045)3.88997392
70cholesterol efflux (GO:0033344)3.88489033
71negative regulation of immunoglobulin mediated immune response (GO:0002890)3.86484626
72negative regulation of B cell mediated immunity (GO:0002713)3.86484626
73negative regulation of complement activation (GO:0045916)3.84820650
74bile acid and bile salt transport (GO:0015721)3.84314048
75acute inflammatory response (GO:0002526)3.83687708
76negative regulation of lipase activity (GO:0060192)3.80932637
77arginine metabolic process (GO:0006525)3.76241986
78imidazole-containing compound metabolic process (GO:0052803)3.75971095
79phospholipid homeostasis (GO:0055091)3.75143152
80cellular amino acid catabolic process (GO:0009063)3.72375198
81blood coagulation, intrinsic pathway (GO:0007597)3.72082738
82oxidative demethylation (GO:0070989)3.71920086
83positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.71424606
84negative regulation of humoral immune response (GO:0002921)3.70693366
85cellular ketone body metabolic process (GO:0046950)3.69992715
86indolalkylamine metabolic process (GO:0006586)3.68960373
87positive regulation of lipid catabolic process (GO:0050996)3.65351855
88plasma lipoprotein particle assembly (GO:0034377)3.64021913
89ethanol oxidation (GO:0006069)3.61506542
90drug catabolic process (GO:0042737)3.61103075
91glutamate metabolic process (GO:0006536)3.60479231
92cellular biogenic amine catabolic process (GO:0042402)3.59967450
93amine catabolic process (GO:0009310)3.59967450
94benzene-containing compound metabolic process (GO:0042537)3.59956715
95cytolysis (GO:0019835)3.59469624
96uronic acid metabolic process (GO:0006063)3.58594799
97glucuronate metabolic process (GO:0019585)3.58594799
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.58361232
99negative regulation of protein activation cascade (GO:2000258)3.56890620
100glycine metabolic process (GO:0006544)3.56880888
101cholesterol homeostasis (GO:0042632)3.54509583
102heme transport (GO:0015886)3.50816288
103cellular modified amino acid catabolic process (GO:0042219)3.50429503
104positive regulation by symbiont of host defense response (GO:0052509)3.49234912
105modulation by symbiont of host defense response (GO:0052031)3.49234912
106modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.49234912
107modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.49234912
108positive regulation by organism of defense response of other organism involved in symbiotic interact3.49234912
109modulation by symbiont of host immune response (GO:0052553)3.49234912
110sterol homeostasis (GO:0055092)3.48950898
111negative regulation of cell killing (GO:0031342)3.48003430
112negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.48003430
113regulation of humoral immune response (GO:0002920)3.47329983
114plasma lipoprotein particle organization (GO:0071827)3.47225760
115serine family amino acid metabolic process (GO:0009069)3.46831148
116regulation of acute inflammatory response (GO:0002673)3.46559427
117alkaloid metabolic process (GO:0009820)3.46551560
118regulation of cholesterol homeostasis (GO:2000188)3.46348072
119detection of biotic stimulus (GO:0009595)3.45657477
120cellular glucuronidation (GO:0052695)3.43692553
121exogenous drug catabolic process (GO:0042738)3.42261221
122aldehyde catabolic process (GO:0046185)3.39882536
123low-density lipoprotein particle remodeling (GO:0034374)3.39413673
124dicarboxylic acid biosynthetic process (GO:0043650)3.39363684
125positive regulation of triglyceride metabolic process (GO:0090208)3.38493072
126acetyl-CoA metabolic process (GO:0006084)3.38327604
127negative regulation of lymphocyte mediated immunity (GO:0002707)3.36943394
128ethanol metabolic process (GO:0006067)3.36064848
129positive regulation of fatty acid beta-oxidation (GO:0032000)3.36002661
130cofactor catabolic process (GO:0051187)3.33723792
131macrophage activation involved in immune response (GO:0002281)3.33531836
132carboxylic acid catabolic process (GO:0046395)3.32142658
133organic acid catabolic process (GO:0016054)3.32142658
134fatty acid oxidation (GO:0019395)3.30070895
135regulation of plasminogen activation (GO:0010755)3.29588880
136phenylpropanoid metabolic process (GO:0009698)3.28852407
137protein-lipid complex assembly (GO:0065005)3.28267331
138antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.22020161
139negative regulation of blood coagulation (GO:0030195)3.17350902
140negative regulation of hemostasis (GO:1900047)3.17350902
141positive regulation of blood coagulation (GO:0030194)3.15393730
142positive regulation of hemostasis (GO:1900048)3.15393730
143neutrophil activation involved in immune response (GO:0002283)3.14574225
144antigen processing and presentation of endogenous antigen (GO:0019883)3.13697253
145flavonoid metabolic process (GO:0009812)3.11386567
146disruption of cells of other organism (GO:0044364)3.08851885
147killing of cells of other organism (GO:0031640)3.08851885
148regulation of apoptotic cell clearance (GO:2000425)3.01632403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.39742975
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.40741732
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.95788796
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.84071585
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.78854259
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.02239602
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.48190875
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.74931393
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.29823623
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.60524848
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28739843
12CLOCK_20551151_ChIP-Seq_293T_Human2.27658167
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14590678
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.13401298
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12181667
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.03861051
17* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5949082
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85682858
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.73659668
20RUNX_20019798_ChIP-Seq_JUKART_Human1.69523174
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66636913
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64199591
23SPI1_23127762_ChIP-Seq_K562_Human1.61472343
24* SPI1_23547873_ChIP-Seq_NB4_Human1.60376578
25* VDR_24763502_ChIP-Seq_THP-1_Human1.60023115
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57674198
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55935987
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.50452438
29VDR_21846776_ChIP-Seq_THP-1_Human1.47731494
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.47517631
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.44662951
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43474433
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38121071
34GATA1_22025678_ChIP-Seq_K562_Human1.36447792
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.33446324
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33176599
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32520565
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.32133560
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31696988
40CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30291355
41VDR_24787735_ChIP-Seq_THP-1_Human1.28528054
42MAF_26560356_Chip-Seq_TH1_Human1.28148664
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25411064
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.24271982
45BCL6_27268052_Chip-Seq_Bcells_Human1.24190167
46GATA3_26560356_Chip-Seq_TH2_Human1.24001722
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22428294
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19563702
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17665450
50HNF4A_19822575_ChIP-Seq_HepG2_Human1.17248581
51* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14419645
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14400403
53UTX_26944678_Chip-Seq_JUKART_Human1.13352462
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12074269
55MYB_26560356_Chip-Seq_TH2_Human1.12034319
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10390318
57CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09618614
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09478084
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09295112
60MYB_26560356_Chip-Seq_TH1_Human1.09054284
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08749053
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.06240089
63SCL_19346495_ChIP-Seq_HPC-7_Human1.05629874
64SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04374247
65GATA3_27048872_Chip-Seq_THYMUS_Human1.03872218
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01796769
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01753228
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00567891
69SPI1_20517297_ChIP-Seq_HL60_Human1.00306301
70LXR_22292898_ChIP-Seq_THP-1_Human1.00070303
71E2F1_20622854_ChIP-Seq_HELA_Human0.99967741
72GATA2_21666600_ChIP-Seq_HMVEC_Human0.99916975
73RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99722140
74SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98845250
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98758472
76HTT_18923047_ChIP-ChIP_STHdh_Human0.98259734
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98255729
78STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98196648
79ESR1_21235772_ChIP-Seq_MCF-7_Human0.97596366
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97562656
81P300_27268052_Chip-Seq_Bcells_Human0.96498905
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94668044
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93435690
84SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92605498
85SA1_27219007_Chip-Seq_Bcells_Human0.91774338
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90806362
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.89770381
88TCF7_22412390_ChIP-Seq_EML_Mouse0.89470744
89RAC3_21632823_ChIP-Seq_H3396_Human0.88745550
90MAF_26560356_Chip-Seq_TH2_Human0.88632368
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86822616
92TRIM28_21343339_ChIP-Seq_HEK293_Human0.86012820
93ZNF263_19887448_ChIP-Seq_K562_Human0.85846159
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85656761
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85480194
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.85465324
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82225973
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82039982
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81497505
100NANOG_20526341_ChIP-Seq_ESCs_Human0.81419552
101SMC4_20622854_ChIP-Seq_HELA_Human0.81384507
102SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81246452
103EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80395888
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80313307
105GATA4_25053715_ChIP-Seq_YYC3_Human0.80253657
106ERA_21632823_ChIP-Seq_H3396_Human0.79720501
107GATA1_19941826_ChIP-Seq_K562_Human0.78618147
108PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78534360
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78457320
110NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.75101362
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.73481010
112BRD4_27068464_Chip-Seq_AML-cells_Mouse0.72278238
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.72218372
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69530068
115* RACK7_27058665_Chip-Seq_MCF-7_Human0.68582638
116* SOX2_20726797_ChIP-Seq_SW620_Human0.67821664
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.66225644
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64939408
119BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64936249
120GATA2_19941826_ChIP-Seq_K562_Human0.64885326
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64739979
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64739979
123IRF8_27001747_Chip-Seq_BMDM_Mouse0.64461676
124ELK3_25401928_ChIP-Seq_HUVEC_Human0.64096378
125AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64079673
126MYB_21317192_ChIP-Seq_ERMYB_Mouse0.63297532
127GATA1_19941827_ChIP-Seq_MEL_Mouse0.62263392
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.61717515
129EGR1_19032775_ChIP-ChIP_M12_Human0.61636159
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61500172
131RARA_24833708_ChIP-Seq_LIVER_Mouse0.60955677
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.60891551
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.59499265
134PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.58466692
135CEBPB_22108803_ChIP-Seq_LS180_Human0.58251545
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.57884846
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57000490
138RARB_24833708_ChIP-Seq_LIVER_Mouse0.55810391
139MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.55209072
140TBX20_22328084_ChIP-Seq_HEART_Mouse0.54722185
141TBX20_22080862_ChIP-Seq_HEART_Mouse0.54722185
142PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.54182879
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.51610693
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.51265464
145FOXA1_25552417_ChIP-Seq_VCAP_Human0.51115585
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50911394
147PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50422410
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.50343265
149FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50303822
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49681143
151* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49184700
152GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.47781531
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.47759587
154BCOR_27268052_Chip-Seq_Bcells_Human0.47670060
155NFIB_24661679_ChIP-Seq_LUNG_Mouse0.47529498
156IRF8_21731497_ChIP-ChIP_J774_Mouse0.47360768
157POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.47360311
158SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.46369960

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.81773938
2MP0005360_urolithiasis6.34737002
3MP0005085_abnormal_gallbladder_physiolo5.48006008
4MP0005365_abnormal_bile_salt5.30792737
5MP0008875_abnormal_xenobiotic_pharmacok4.18629211
6MP0010329_abnormal_lipoprotein_level3.49237435
7MP0003806_abnormal_nucleotide_metabolis3.42588095
8MP0009840_abnormal_foam_cell3.23371840
9MP0003191_abnormal_cellular_cholesterol3.22219859
10MP0003252_abnormal_bile_duct3.17276600
11MP0010368_abnormal_lymphatic_system2.97620310
12MP0003724_increased_susceptibility_to2.77241994
13MP0005083_abnormal_biliary_tract2.66786767
14MP0002132_abnormal_respiratory_system2.38920006
15MP0005332_abnormal_amino_acid2.38066839
16MP0001666_abnormal_nutrient_absorption2.20099307
17MP0000609_abnormal_liver_physiology2.16997717
18MP0003195_calcinosis2.05180589
19MP0002138_abnormal_hepatobiliary_system2.04014587
20MP0002118_abnormal_lipid_homeostasis2.03769319
21MP0001835_abnormal_antigen_presentation1.96586101
22MP0004019_abnormal_vitamin_homeostasis1.94271189
23MP0000685_abnormal_immune_system1.90995952
24MP0001790_abnormal_immune_system1.87802578
25MP0005387_immune_system_phenotype1.87802578
26MP0001800_abnormal_humoral_immune1.79934432
27MP0005319_abnormal_enzyme/_coenzyme1.79860192
28MP0005670_abnormal_white_adipose1.74575173
29MP0005000_abnormal_immune_tolerance1.67637121
30MP0006082_CNS_inflammation1.64644560
31MP0006054_spinal_hemorrhage1.63724362
32MP0002148_abnormal_hypersensitivity_rea1.63454546
33MP0002723_abnormal_immune_serum1.59991760
34MP0005671_abnormal_response_to1.58987389
35MP0001879_abnormal_lymphatic_vessel1.54851757
36MP0002277_abnormal_respiratory_mucosa1.46742295
37MP0008004_abnormal_stomach_pH1.45715674
38MP0001764_abnormal_homeostasis1.43881229
39MP0005584_abnormal_enzyme/coenzyme_acti1.43390030
40MP0010155_abnormal_intestine_physiology1.41102567
41MP0003705_abnormal_hypodermis_morpholog1.41058376
42MP0004130_abnormal_muscle_cell1.41040940
43MP0002452_abnormal_antigen_presenting1.40441189
44MP0002420_abnormal_adaptive_immunity1.35622792
45MP0001819_abnormal_immune_cell1.34943988
46MP0003868_abnormal_feces_composition1.34923336
47MP0009764_decreased_sensitivity_to1.31338579
48MP0003011_delayed_dark_adaptation1.29492695
49MP0003300_gastrointestinal_ulcer1.28697853
50MP0009763_increased_sensitivity_to1.27117007
51MP0002254_reproductive_system_inflammat1.21965248
52MP0000013_abnormal_adipose_tissue1.20633428
53MP0000598_abnormal_liver_morphology1.20475155
54MP0000604_amyloidosis1.20054549
55MP0003436_decreased_susceptibility_to1.18910304
56MP0002405_respiratory_system_inflammati1.18519070
57MP0009643_abnormal_urine_homeostasis1.16111539
58MP0003656_abnormal_erythrocyte_physiolo1.14322637
59MP0003186_abnormal_redox_activity1.13461553
60MP0008469_abnormal_protein_level1.11255495
61MP0005167_abnormal_blood-brain_barrier1.05698633
62MP0003866_abnormal_defecation1.05133861
63MP0005451_abnormal_body_composition1.05068252
64MP0000716_abnormal_immune_system0.97501271
65MP0003183_abnormal_peptide_metabolism0.97273084
66MP0005397_hematopoietic_system_phenotyp0.96844698
67MP0001545_abnormal_hematopoietic_system0.96844698
68MP0005666_abnormal_adipose_tissue0.95219389
69MP0004947_skin_inflammation0.94253667
70MP0009697_abnormal_copulation0.93824065
71MP0001851_eye_inflammation0.93041230
72MP0002837_dystrophic_cardiac_calcinosis0.92333482
73MP0005636_abnormal_mineral_homeostasis0.92096345
74MP0002971_abnormal_brown_adipose0.91056036
75MP0009333_abnormal_splenocyte_physiolog0.90656840
76MP0003690_abnormal_glial_cell0.90280442
77MP0003172_abnormal_lysosome_physiology0.88951862
78MP0000689_abnormal_spleen_morphology0.87561260
79MP0004782_abnormal_surfactant_physiolog0.87441787
80MP0009642_abnormal_blood_homeostasis0.87268879
81MP0009765_abnormal_xenobiotic_induced0.87137585
82MP0004510_myositis0.86563244
83MP0005647_abnormal_sex_gland0.85755023
84MP0003878_abnormal_ear_physiology0.84727797
85MP0005377_hearing/vestibular/ear_phenot0.84727797
86MP0003879_abnormal_hair_cell0.83472650
87MP0003075_altered_response_to0.81976744
88MP0002398_abnormal_bone_marrow0.81360683
89MP0003303_peritoneal_inflammation0.80102668
90MP0001661_extended_life_span0.79483144
91MP0001533_abnormal_skeleton_physiology0.78371470
92MP0005376_homeostasis/metabolism_phenot0.77388391
93MP0000858_altered_metastatic_potential0.77065677
94MP0002722_abnormal_immune_system0.76142938
95MP0009278_abnormal_bone_marrow0.74809027
96MP0001663_abnormal_digestive_system0.74361127
97MP0005334_abnormal_fat_pad0.73980346
98MP0005464_abnormal_platelet_physiology0.73796542
99MP0001986_abnormal_taste_sensitivity0.73560481
100MP0003828_pulmonary_edema0.72304482
101MP0002078_abnormal_glucose_homeostasis0.71703800
102MP0005164_abnormal_response_to0.71360550
103MP0005058_abnormal_lysosome_morphology0.71301328
104MP0002928_abnormal_bile_duct0.71044308
105MP0008260_abnormal_autophagy0.70707834
106MP0000249_abnormal_blood_vessel0.70616851
107MP0002429_abnormal_blood_cell0.70514793
108MP0002796_impaired_skin_barrier0.67984631
109MP0005375_adipose_tissue_phenotype0.66945914
110MP0002419_abnormal_innate_immunity0.66939994
111MP0004185_abnormal_adipocyte_glucose0.64421345
112MP0004883_abnormal_blood_vessel0.62668974
113MP0006036_abnormal_mitochondrial_physio0.62324900
114MP0005535_abnormal_body_temperature0.59911715
115MP0009785_altered_susceptibility_to0.59835846
116MP0005166_decreased_susceptibility_to0.59510495
117MP0000343_altered_response_to0.58861474
118MP0005025_abnormal_response_to0.58861132
119MP0005023_abnormal_wound_healing0.57881564
120MP0001881_abnormal_mammary_gland0.57821618
121MP0001845_abnormal_inflammatory_respons0.57326500
122MP0003638_abnormal_response/metabolism_0.57058333
123MP0003329_amyloid_beta_deposits0.56846824
124MP0001756_abnormal_urination0.56621642
125MP0008874_decreased_physiological_sensi0.54951409
126MP0000465_gastrointestinal_hemorrhage0.54675714
127MP0005408_hypopigmentation0.52984128
128MP0001243_abnormal_dermal_layer0.52647105
129MP0002876_abnormal_thyroid_physiology0.52644242
130MP0008873_increased_physiological_sensi0.52435363
131MP0008438_abnormal_cutaneous_collagen0.51682570
132MP0003453_abnormal_keratinocyte_physiol0.50535214
133MP0005448_abnormal_energy_balance0.49582774
134MP0002136_abnormal_kidney_physiology0.49375769
135MP0005595_abnormal_vascular_smooth0.49361383
136MP0000639_abnormal_adrenal_gland0.47670308
137MP0005084_abnormal_gallbladder_morpholo0.47582708
138MP0004272_abnormal_basement_membrane0.47557598
139MP0005220_abnormal_exocrine_pancreas0.47175297
140MP0009115_abnormal_fat_cell0.46537594

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.62719853
2Prolonged partial thromboplastin time (HP:0003645)6.43989558
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.39134738
4Complement deficiency (HP:0004431)6.29122502
5Intrahepatic cholestasis (HP:0001406)6.23880090
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.02115713
7Xanthomatosis (HP:0000991)5.75382141
8Hyperlipoproteinemia (HP:0010980)5.38481590
9Hypobetalipoproteinemia (HP:0003563)5.22866458
10Joint hemorrhage (HP:0005261)5.00967379
11Abnormality of complement system (HP:0005339)4.79065002
12Abnormality of the common coagulation pathway (HP:0010990)4.74806398
13Orchitis (HP:0100796)4.72125684
14Myositis (HP:0100614)4.67280304
15Retrobulbar optic neuritis (HP:0100654)4.55340994
16Optic neuritis (HP:0100653)4.55340994
17Hypolipoproteinemia (HP:0010981)4.43594556
18Hypoalphalipoproteinemia (HP:0003233)4.41653904
19Eczematoid dermatitis (HP:0000976)4.37347389
20Hyperammonemia (HP:0001987)4.16830465
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.14330763
22Systemic lupus erythematosus (HP:0002725)4.07030685
23Recurrent abscess formation (HP:0002722)4.03516571
24Epidermoid cyst (HP:0200040)3.95963230
25Abnormality of the intrinsic pathway (HP:0010989)3.89866135
26Ketosis (HP:0001946)3.77243000
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.66801072
28Hyperglycinemia (HP:0002154)3.66521178
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.61360641
30Abnormality of methionine metabolism (HP:0010901)3.54720360
31Nonimmune hydrops fetalis (HP:0001790)3.52869932
32Hypoglycemic coma (HP:0001325)3.51725429
33Fat malabsorption (HP:0002630)3.51291551
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.49455106
35Stomatitis (HP:0010280)3.48165498
36Recurrent bacterial skin infections (HP:0005406)3.43824957
37Hyperglycinuria (HP:0003108)3.40599613
38Recurrent gram-negative bacterial infections (HP:0005420)3.39284207
39Abnormality of macrophages (HP:0004311)3.37199351
40Spontaneous abortion (HP:0005268)3.35104481
41Abnormality of glycine metabolism (HP:0010895)3.33164766
42Abnormality of serine family amino acid metabolism (HP:0010894)3.33164766
43Hypochromic anemia (HP:0001931)3.22771601
44Abnormality of pyrimidine metabolism (HP:0004353)3.21930975
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17348929
46Hypercholesterolemia (HP:0003124)3.16340793
47Abnormality of fatty-acid metabolism (HP:0004359)3.16239918
48Keratoconjunctivitis sicca (HP:0001097)3.13368399
49Elevated erythrocyte sedimentation rate (HP:0003565)3.13040102
50Purpura (HP:0000979)3.10787505
51Glomerulonephritis (HP:0000099)3.06826204
52Meningitis (HP:0001287)3.06364696
53Amyloidosis (HP:0011034)3.04381369
54Gastrointestinal infarctions (HP:0005244)3.03608641
55Gangrene (HP:0100758)3.01731347
56Keratoconjunctivitis (HP:0001096)3.00019619
57Myocardial infarction (HP:0001658)2.96525686
58Anorexia (HP:0002039)2.94785815
59Chronic obstructive pulmonary disease (HP:0006510)2.93467774
60Obstructive lung disease (HP:0006536)2.93467774
61Abnormality of nucleobase metabolism (HP:0010932)2.92802291
62Conjugated hyperbilirubinemia (HP:0002908)2.90687775
63Vascular calcification (HP:0004934)2.85234894
64Abnormality of purine metabolism (HP:0004352)2.78237948
65Hyperbilirubinemia (HP:0002904)2.74055466
66Esophageal varix (HP:0002040)2.69836848
67Steatorrhea (HP:0002570)2.69739590
68Ketoacidosis (HP:0001993)2.67676139
69Hepatocellular carcinoma (HP:0001402)2.66938831
70Skin nodule (HP:0200036)2.61486418
71Encephalitis (HP:0002383)2.60134598
72Joint swelling (HP:0001386)2.58174374
73Cardiovascular calcification (HP:0011915)2.56501214
74Gingival bleeding (HP:0000225)2.56347821
75Delayed CNS myelination (HP:0002188)2.50267574
76Abnormality of serum amino acid levels (HP:0003112)2.47543764
77Gout (HP:0001997)2.46611948
78Vasculitis (HP:0002633)2.45257871
79Thrombophlebitis (HP:0004418)2.45238309
80Recurrent skin infections (HP:0001581)2.44320120
81Gingivitis (HP:0000230)2.44186940
82Mediastinal lymphadenopathy (HP:0100721)2.42738456
83Arterial thrombosis (HP:0004420)2.40136372
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39881496
85Dicarboxylic aciduria (HP:0003215)2.39881496
86Increased IgE level (HP:0003212)2.35546390
87Recurrent fungal infections (HP:0002841)2.34704203
88Metabolic acidosis (HP:0001942)2.34147725
89Hemoptysis (HP:0002105)2.33753707
90Hemorrhage of the eye (HP:0011885)2.32700729
91Mitral stenosis (HP:0001718)2.29741783
92Nephritis (HP:0000123)2.28022729
93Urticaria (HP:0001025)2.23214801
94Pulmonary infiltrates (HP:0002113)2.23131977
95Hypochromic microcytic anemia (HP:0004840)2.22579357
96Lethargy (HP:0001254)2.22520442
97Spastic diplegia (HP:0001264)2.21592357
98Prolonged bleeding time (HP:0003010)2.21559880
99Menorrhagia (HP:0000132)2.18813969
100Abnormality of iron homeostasis (HP:0011031)2.17724202
101Microcytic anemia (HP:0001935)2.17405027
102Abnormal delayed hypersensitivity skin test (HP:0002963)2.16990763
103Episodic fever (HP:0001954)2.16685915
104Abnormal gallbladder physiology (HP:0012438)2.16053024
105Cholecystitis (HP:0001082)2.16053024
106Irritability (HP:0000737)2.11651105
107Osteomalacia (HP:0002749)2.10960597
108Polycythemia (HP:0001901)2.10489372
109Neonatal onset (HP:0003623)2.08643924
110Cholelithiasis (HP:0001081)2.07922734
111Abnormal gallbladder morphology (HP:0012437)2.07694224
112Sensorimotor neuropathy (HP:0007141)2.07318275
113Hypoglycemic seizures (HP:0002173)2.06417093
114Abnormality of transition element cation homeostasis (HP:0011030)2.05396935
115Hypertriglyceridemia (HP:0002155)2.05072154
116Pancreatitis (HP:0001733)2.04561840
117Acne (HP:0001061)2.02644886
118Abnormality of the pleura (HP:0002103)1.99777260
119Pulmonary embolism (HP:0002204)1.98792495
120Malnutrition (HP:0004395)1.94523164
121Late onset (HP:0003584)1.89628385
122Vomiting (HP:0002013)1.89108864
123Cerebral edema (HP:0002181)1.87777277
124Abnormal enzyme/coenzyme activity (HP:0012379)1.82464382
125Increased serum ferritin (HP:0003281)1.81984270
126Brushfield spots (HP:0001088)1.81964078
127Increased purine levels (HP:0004368)1.81233582
128Hyperuricemia (HP:0002149)1.81233582
129Hyperglycemia (HP:0003074)1.80896520
130Abnormality of alkaline phosphatase activity (HP:0004379)1.80022134
131Spontaneous hematomas (HP:0007420)1.79057995
132Generalized aminoaciduria (HP:0002909)1.77991716
133Recurrent cutaneous fungal infections (HP:0011370)1.77070262
134Chronic mucocutaneous candidiasis (HP:0002728)1.77070262
135Rickets (HP:0002748)1.76089177
136Abnormality of the gallbladder (HP:0005264)1.75580341
137Peritonitis (HP:0002586)1.74651119
138Epistaxis (HP:0000421)1.74362966
139Abnormal cartilage morphology (HP:0002763)1.73615144
140Acanthocytosis (HP:0001927)1.72562114
141Opisthotonus (HP:0002179)1.70279997
142Lymphangioma (HP:0100764)1.67999020
143Arthropathy (HP:0003040)1.64621880
144Abnormality of the pericardium (HP:0001697)1.64101604
145Elevated alkaline phosphatase (HP:0003155)1.63033322
146Skin rash (HP:0000988)1.60187835
147Chest pain (HP:0100749)1.58457706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR8.29721660
2ERN15.42372676
3BCKDK4.27268494
4TIE14.15254087
5RIPK43.82445035
6FGFR43.27963523
7IRAK43.22503906
8SIK12.84216187
9TNK22.45804898
10TGFBR22.43828702
11EPHB12.20483744
12TRIB32.19661731
13MST1R2.05085164
14FES1.94025503
15TAOK11.90844603
16TXK1.77576072
17TAOK31.74468493
18JAK11.67861843
19PTK61.65532143
20INSRR1.65211280
21DAPK21.62131432
22PKN21.56534143
23ERBB41.54459343
24TYK21.48211970
25JAK21.43890300
26RIPK11.42790752
27SYK1.39026424
28MAP2K31.31993401
29EPHA31.25260843
30MAP2K41.22646423
31FGR1.19415170
32MATK1.14492676
33IKBKB1.14411039
34MAPK111.10211293
35BLK1.09579832
36FLT31.08958500
37MAP3K111.03725703
38CAMK1D1.03665632
39MET1.02150839
40LCK1.00714722
41MAP3K30.99133921
42TGFBR10.97625471
43CSK0.97539962
44GRK10.96245172
45PRKD20.95753947
46TBK10.95013400
47JAK30.92301696
48CAMK40.92102887
49NEK90.91806726
50MAP3K20.87360283
51NLK0.84465272
52PTK20.82428806
53TLK10.81939683
54MAPK120.80481432
55KSR20.78909883
56ABL20.78476521
57YES10.78370125
58GRK60.78330029
59PIK3CG0.77917558
60TAOK20.77887018
61PRKAA20.77117747
62FGFR20.77113696
63MARK20.76041765
64SIK30.73756262
65MAP3K70.71138297
66ITK0.70817604
67SIK20.70593408
68FRK0.67986453
69LATS10.66881992
70MAPK150.65920324
71FGFR30.65876603
72MARK30.65427871
73MAPK40.65008822
74EPHB20.63448289
75PRKCQ0.63258594
76MAP4K10.62752477
77MAP2K10.61317446
78MAP3K10.59606679
79PRPF4B0.59324725
80FER0.58201207
81ADRBK20.58118233
82STK110.57642557
83ERBB20.57409418
84CAMK1G0.56674300
85MAP3K50.56497318
86HIPK20.56311572
87RET0.55159501
88GSK3A0.53640400
89EPHA20.52962412
90FYN0.52414631
91ZAP700.51663422
92MAP3K100.51130176
93IRAK20.51076779
94MAP3K130.51048919
95MAP3K140.50794607
96STK380.49878473
97IGF1R0.49820244
98CAMKK20.48082391
99GRK70.45884789
100EGFR0.45471475
101PTK2B0.45392475
102CHUK0.43528511
103PRKCZ0.43085422
104PDPK10.43074494
105PRKACG0.42727733
106RPS6KA60.42236105
107CDK60.42098797
108CDC42BPA0.41969837
109MAP2K20.41656137
110MAPKAPK20.40532288
111PRKCH0.40009035
112PIK3CA0.39738907
113MAP2K60.37847659
114IKBKE0.37593349
115BMPR20.36091762
116ADRBK10.35169830
117SMG10.35063858
118RPS6KC10.34904872
119IRAK30.34427332
120MYLK0.33926862
121BMX0.32467664
122LRRK20.31633953
123PRKAA10.30999906
124CSF1R0.30468983
125MAPK70.29937216
126TTN0.29537532
127PINK10.29292284
128SGK30.29034170
129CDK90.28619258
130BTK0.28304859
131PRKG20.27902483
132CAMK2G0.27830416
133DYRK1B0.21413820
134HCK0.20808701
135PDK10.20761189
136PRKCD0.19988728
137TEC0.19404729
138LYN0.18806519
139MAP3K60.18582704
140FGFR10.18188851
141IRAK10.18118416
142KIT0.18043558
143STK100.17811206
144PDGFRA0.17706130

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.46246954
2Complement and coagulation cascades_Homo sapiens_hsa046103.56950837
3Nitrogen metabolism_Homo sapiens_hsa009103.44097652
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37571082
5Arginine biosynthesis_Homo sapiens_hsa002203.15906089
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.98473619
7Staphylococcus aureus infection_Homo sapiens_hsa051502.68777020
8Tryptophan metabolism_Homo sapiens_hsa003802.52659435
9Fatty acid degradation_Homo sapiens_hsa000712.50953179
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45772499
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42998920
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36645225
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33449743
14Caffeine metabolism_Homo sapiens_hsa002322.21888945
15PPAR signaling pathway_Homo sapiens_hsa033202.18072184
16Peroxisome_Homo sapiens_hsa041462.05545119
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00812632
18Butanoate metabolism_Homo sapiens_hsa006501.89236256
19Propanoate metabolism_Homo sapiens_hsa006401.88371672
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88203142
21Histidine metabolism_Homo sapiens_hsa003401.88057624
22Fatty acid metabolism_Homo sapiens_hsa012121.82599501
23Chemical carcinogenesis_Homo sapiens_hsa052041.71763095
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66668180
25beta-Alanine metabolism_Homo sapiens_hsa004101.64953465
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.59231303
27Phenylalanine metabolism_Homo sapiens_hsa003601.58783657
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57258841
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55642055
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.53691925
31Bile secretion_Homo sapiens_hsa049761.48371188
32Retinol metabolism_Homo sapiens_hsa008301.46404458
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38665010
34Selenocompound metabolism_Homo sapiens_hsa004501.37132779
35Tyrosine metabolism_Homo sapiens_hsa003501.36011407
36ABC transporters_Homo sapiens_hsa020101.34448239
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33278331
38Pyruvate metabolism_Homo sapiens_hsa006201.29488982
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26057562
40Osteoclast differentiation_Homo sapiens_hsa043801.23303455
41Fat digestion and absorption_Homo sapiens_hsa049751.23275623
42Fatty acid elongation_Homo sapiens_hsa000621.21836208
43Starch and sucrose metabolism_Homo sapiens_hsa005001.21540679
44Sulfur metabolism_Homo sapiens_hsa009201.20457509
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.18160306
46Folate biosynthesis_Homo sapiens_hsa007901.16312762
47Biosynthesis of amino acids_Homo sapiens_hsa012301.14323750
48Carbon metabolism_Homo sapiens_hsa012001.09551637
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96815203
50Sulfur relay system_Homo sapiens_hsa041220.92981319
51Vitamin digestion and absorption_Homo sapiens_hsa049770.92773675
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92087490
53Steroid biosynthesis_Homo sapiens_hsa001000.88182144
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87986264
55Arginine and proline metabolism_Homo sapiens_hsa003300.82414970
56Graft-versus-host disease_Homo sapiens_hsa053320.80963281
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.80301287
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78977514
59Tuberculosis_Homo sapiens_hsa051520.77829500
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77312574
61Vitamin B6 metabolism_Homo sapiens_hsa007500.76680572
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76606646
63Glycerolipid metabolism_Homo sapiens_hsa005610.75289140
64Allograft rejection_Homo sapiens_hsa053300.75082359
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.72380870
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72131352
67Lysine degradation_Homo sapiens_hsa003100.70762335
68Pentose phosphate pathway_Homo sapiens_hsa000300.69255567
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66204440
70Fatty acid biosynthesis_Homo sapiens_hsa000610.66078690
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65959198
72Autoimmune thyroid disease_Homo sapiens_hsa053200.64616971
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.61502604
74Prion diseases_Homo sapiens_hsa050200.58725495
75Glutathione metabolism_Homo sapiens_hsa004800.57279974
76Legionellosis_Homo sapiens_hsa051340.56374941
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56011213
78B cell receptor signaling pathway_Homo sapiens_hsa046620.52192111
79Primary immunodeficiency_Homo sapiens_hsa053400.50631596
80Hematopoietic cell lineage_Homo sapiens_hsa046400.50310105
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.48981389
82Type I diabetes mellitus_Homo sapiens_hsa049400.46780250
83Measles_Homo sapiens_hsa051620.46052183
84Chemokine signaling pathway_Homo sapiens_hsa040620.45809198
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.45692311
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45515249
87Phagosome_Homo sapiens_hsa041450.43560320
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43011909
89Influenza A_Homo sapiens_hsa051640.43010029
90Insulin resistance_Homo sapiens_hsa049310.42908953
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41641574
92TNF signaling pathway_Homo sapiens_hsa046680.40673943
93Malaria_Homo sapiens_hsa051440.40450175
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39122437
95Metabolic pathways_Homo sapiens_hsa011000.37641117
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.33947278
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32031647
98One carbon pool by folate_Homo sapiens_hsa006700.31659550
99African trypanosomiasis_Homo sapiens_hsa051430.29784357
100Antigen processing and presentation_Homo sapiens_hsa046120.29637886
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.29518773
102Acute myeloid leukemia_Homo sapiens_hsa052210.28796938
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28490966
104Galactose metabolism_Homo sapiens_hsa000520.27683647
105Toxoplasmosis_Homo sapiens_hsa051450.27416689
106Systemic lupus erythematosus_Homo sapiens_hsa053220.26418037
107Herpes simplex infection_Homo sapiens_hsa051680.24224276
108Fructose and mannose metabolism_Homo sapiens_hsa000510.23813760
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.22783738
110Linoleic acid metabolism_Homo sapiens_hsa005910.20559379
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.19961346
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.19397749
113Pertussis_Homo sapiens_hsa051330.17112951
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15105463
115AMPK signaling pathway_Homo sapiens_hsa041520.14172855
116Glucagon signaling pathway_Homo sapiens_hsa049220.09764628
117Lysosome_Homo sapiens_hsa041420.04472534
118Amoebiasis_Homo sapiens_hsa051460.01334371
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.01152167
120Other glycan degradation_Homo sapiens_hsa005110.00427080
121Hepatitis C_Homo sapiens_hsa05160-4.2540764
122Leishmaniasis_Homo sapiens_hsa05140-0.1268449
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1247235
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532-0.1242808
125Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1217907
126Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.1180787
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1087700
128Bladder cancer_Homo sapiens_hsa05219-0.0810491
129Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0638449
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0624640
131Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0501788
132Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0262990
133Insulin signaling pathway_Homo sapiens_hsa04910-0.0119474
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0040273

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