LRIF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.66244520
2nuclear pore organization (GO:0006999)5.26987831
3pore complex assembly (GO:0046931)4.63425855
4interferon-gamma production (GO:0032609)4.52961418
5positive regulation of gamma-delta T cell activation (GO:0046645)4.30000868
6proteasome assembly (GO:0043248)4.26727117
7rRNA methylation (GO:0031167)4.23213797
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.19201107
9ribosome assembly (GO:0042255)4.18668707
10centriole replication (GO:0007099)3.96237794
11regulation of B cell receptor signaling pathway (GO:0050855)3.79272541
12rRNA modification (GO:0000154)3.74888598
13NIK/NF-kappaB signaling (GO:0038061)3.73175672
14synapsis (GO:0007129)3.70227505
15regulation of centriole replication (GO:0046599)3.58705056
16positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.55993569
17negative regulation of cell killing (GO:0031342)3.54939484
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54939484
19DNA synthesis involved in DNA repair (GO:0000731)3.52919614
20activated T cell proliferation (GO:0050798)3.51083119
21telomere maintenance via semi-conservative replication (GO:0032201)3.43683341
22regulation of alpha-beta T cell proliferation (GO:0046640)3.43060750
23tRNA aminoacylation for protein translation (GO:0006418)3.40639143
24antigen processing and presentation of endogenous antigen (GO:0019883)3.37816183
25protein-cofactor linkage (GO:0018065)3.37187617
26signal peptide processing (GO:0006465)3.37094511
27regulation of immunoglobulin secretion (GO:0051023)3.36205890
28tRNA aminoacylation (GO:0043039)3.35227401
29amino acid activation (GO:0043038)3.35227401
30ribonucleoprotein complex disassembly (GO:0032988)3.35095104
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.34399409
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34399409
33negative T cell selection (GO:0043383)3.34386950
34histone mRNA metabolic process (GO:0008334)3.32679291
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32459333
36cell wall macromolecule catabolic process (GO:0016998)3.32394017
37multicellular organism reproduction (GO:0032504)3.28501459
38positive regulation of alpha-beta T cell proliferation (GO:0046641)3.28189159
39positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.27233298
40cellular response to interleukin-15 (GO:0071350)3.26627351
41regulation of memory T cell differentiation (GO:0043380)3.26411857
42negative thymic T cell selection (GO:0045060)3.26079913
43B cell receptor signaling pathway (GO:0050853)3.25042981
44DNA double-strand break processing (GO:0000729)3.22194723
45T cell migration (GO:0072678)3.19970989
46neutrophil activation involved in immune response (GO:0002283)3.19940617
47DNA strand elongation involved in DNA replication (GO:0006271)3.19847283
48regulation of B cell differentiation (GO:0045577)3.19580473
49positive regulation of mitochondrial fission (GO:0090141)3.19245674
50mitotic nuclear envelope disassembly (GO:0007077)3.18102794
51leukocyte aggregation (GO:0070486)3.18081118
52spermatid nucleus differentiation (GO:0007289)3.15695474
53DNA replication checkpoint (GO:0000076)3.15684558
54DNA catabolic process, exonucleolytic (GO:0000738)3.15561658
55cullin deneddylation (GO:0010388)3.14530772
56regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.14381344
57regulation of isotype switching to IgG isotypes (GO:0048302)3.11911590
58centriole assembly (GO:0098534)3.11008591
59response to type I interferon (GO:0034340)3.10948586
60cellular response to interferon-beta (GO:0035458)3.10704136
61DNA strand elongation (GO:0022616)3.09604642
62nucleotide-excision repair, DNA gap filling (GO:0006297)3.08375601
63mitotic metaphase plate congression (GO:0007080)3.07118745
64telomere maintenance via recombination (GO:0000722)3.06647935
65regulation of RIG-I signaling pathway (GO:0039535)3.05993266
66cellular response to type I interferon (GO:0071357)3.05624505
67type I interferon signaling pathway (GO:0060337)3.05624505
68regulation of regulatory T cell differentiation (GO:0045589)3.03540181
69positive regulation of B cell differentiation (GO:0045579)3.03039104
70microtubule depolymerization (GO:0007019)3.02365905
71sequestering of actin monomers (GO:0042989)2.98935525
72binding of sperm to zona pellucida (GO:0007339)2.98616693
73sperm-egg recognition (GO:0035036)2.97888695
74mitotic recombination (GO:0006312)2.96842898
75resolution of meiotic recombination intermediates (GO:0000712)2.94927017
76mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.93728101
77positive regulation of interleukin-17 production (GO:0032740)2.93681836
78maturation of 5.8S rRNA (GO:0000460)2.93386385
79DNA packaging (GO:0006323)2.93018452
80RNA-dependent DNA replication (GO:0006278)2.92779637
81mitotic spindle checkpoint (GO:0071174)2.91728710
82membrane disassembly (GO:0030397)2.91432689
83nuclear envelope disassembly (GO:0051081)2.91432689
84response to interleukin-15 (GO:0070672)2.91055397
85metaphase plate congression (GO:0051310)2.90394381
86attachment of spindle microtubules to kinetochore (GO:0008608)2.90175160
87regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.90069485
88organelle disassembly (GO:1903008)2.89461599
89positive regulation of interleukin-2 production (GO:0032743)2.89405014
90folic acid-containing compound biosynthetic process (GO:0009396)2.89401980
91single strand break repair (GO:0000012)2.88906511
92mast cell activation (GO:0045576)2.88182730
93myeloid dendritic cell activation (GO:0001773)2.87555453
94telomere maintenance via telomere lengthening (GO:0010833)2.86788302
95regulation of activation of Janus kinase activity (GO:0010533)2.86556595
96regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86080228
97spindle checkpoint (GO:0031577)2.85770006
98regulation of mitotic spindle checkpoint (GO:1903504)2.84944664
99regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84944664
100telomere maintenance via telomerase (GO:0007004)2.84566348
101termination of RNA polymerase II transcription (GO:0006369)2.83814082
102monoubiquitinated protein deubiquitination (GO:0035520)2.83132190
103positive regulation of defense response to virus by host (GO:0002230)2.83103779
104respiratory burst (GO:0045730)2.82801599
105replication fork processing (GO:0031297)2.82479431
106sister chromatid segregation (GO:0000819)2.81607569
107formation of translation preinitiation complex (GO:0001731)2.81156469
108positive regulation of interferon-gamma production (GO:0032729)2.81013615
109RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.80187357
110cell wall macromolecule metabolic process (GO:0044036)2.80124562
111nucleobase biosynthetic process (GO:0046112)2.80117527
112regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.80115876
113somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.79265155
114isotype switching (GO:0045190)2.79265155
115somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.79265155
116mismatch repair (GO:0006298)2.79175458
117mitotic sister chromatid segregation (GO:0000070)2.78852094
118regulation of chromosome segregation (GO:0051983)2.78538625
119positive regulation of interleukin-12 production (GO:0032735)2.78271133
120acrosome reaction (GO:0007340)2.76685963
121negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76685934
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76685934
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76685934
124negative regulation of mitotic sister chromatid separation (GO:2000816)2.76685934
125negative regulation of sister chromatid segregation (GO:0033046)2.76685934
126defense response to protozoan (GO:0042832)2.76347353
127protein localization to chromosome, centromeric region (GO:0071459)2.75721857
128positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.75406144
129histone H2A acetylation (GO:0043968)2.75401375
130negative regulation of chromosome segregation (GO:0051985)2.75289249
131positive regulation of T-helper 1 type immune response (GO:0002827)2.75260735
132regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.75182369
133fusion of sperm to egg plasma membrane (GO:0007342)2.74176314
134regulation of necroptotic process (GO:0060544)2.73943671
135purine nucleobase biosynthetic process (GO:0009113)2.73871173
136positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73745242
137regulation of centrosome cycle (GO:0046605)2.73660185
138peptidyl-histidine modification (GO:0018202)2.73330755
139neutrophil activation (GO:0042119)2.72382377
140regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.72362394
141positive regulation of antigen processing and presentation (GO:0002579)2.71727264
142regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.71402251
143regulation of mitotic metaphase/anaphase transition (GO:0030071)2.71402251
144chromosome condensation (GO:0030261)2.70782736
145protein deneddylation (GO:0000338)2.70195008
146regulation of T-helper 1 cell differentiation (GO:0045625)2.69713651
147chromosome segregation (GO:0007059)2.69646902
148regulation of interleukin-12 biosynthetic process (GO:0045075)2.69091084
149B cell proliferation (GO:0042100)2.68840938
150positive T cell selection (GO:0043368)2.68737010
151histone mRNA catabolic process (GO:0071044)2.67953637
152mitotic spindle assembly checkpoint (GO:0007094)2.67773435
153dendritic cell chemotaxis (GO:0002407)2.67680674
154microtubule nucleation (GO:0007020)2.67665821
155response to protozoan (GO:0001562)2.67576257
156regulation of helicase activity (GO:0051095)2.67457528
157regulation of interleukin-17 production (GO:0032660)2.67073551
158regulation of mitotic sister chromatid separation (GO:0010965)2.66516649
159regulation of mitotic sister chromatid segregation (GO:0033047)2.66516649
160regulation of sister chromatid segregation (GO:0033045)2.66516649
161positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66177801
162regulation of mitochondrial translation (GO:0070129)2.66108505
163exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65266715
164regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63134716
165regulation of gamma-delta T cell activation (GO:0046643)2.62367331
166superoxide anion generation (GO:0042554)2.61823695
167mature B cell differentiation (GO:0002335)2.61784226
168regulation of gamma-delta T cell differentiation (GO:0045586)2.59563131
169positive regulation of interferon-alpha production (GO:0032727)2.59141608
170mature B cell differentiation involved in immune response (GO:0002313)2.56278436
171regulation of T cell mediated cytotoxicity (GO:0001914)2.56116501
172positive regulation of T cell cytokine production (GO:0002726)2.55714070
173granulocyte activation (GO:0036230)2.55234916
174sperm motility (GO:0030317)2.55011873
175dendritic cell migration (GO:0036336)2.51756141
176antigen receptor-mediated signaling pathway (GO:0050851)2.51486309
177regulation of immunoglobulin production (GO:0002637)2.51150333
178regulation of fibroblast apoptotic process (GO:2000269)2.51067855
179positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.49061403
180regulation of T cell tolerance induction (GO:0002664)2.47877803
181regulation of dendritic cell antigen processing and presentation (GO:0002604)2.46864826
182axonemal dynein complex assembly (GO:0070286)2.46139601
183reproduction (GO:0000003)2.45956648
184T-helper 1 type immune response (GO:0042088)2.45318009
185T cell lineage commitment (GO:0002360)2.44362950
186regulation of interferon-alpha production (GO:0032647)2.44187066
187natural killer cell activation (GO:0030101)2.44111454
188T cell homeostasis (GO:0043029)2.44086430
189regulation of T-helper 1 type immune response (GO:0002825)2.43386986
190interferon-gamma-mediated signaling pathway (GO:0060333)2.42749759
191cilium or flagellum-dependent cell motility (GO:0001539)2.42613533
192T cell selection (GO:0045058)2.41525654
193lymphocyte proliferation (GO:0046651)2.41298823
194negative regulation of viral genome replication (GO:0045071)2.40993615
195regulation of T cell receptor signaling pathway (GO:0050856)2.40601971
196positive regulation of interleukin-10 production (GO:0032733)2.40112281
197positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.39950925
198regulation of B cell activation (GO:0050864)2.39696994
199regulation of interleukin-2 biosynthetic process (GO:0045076)2.39221638
200response to interferon-beta (GO:0035456)2.38797012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.45075285
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.61633855
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.41093610
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.10402010
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.02258882
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.93814477
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.39798496
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.37955451
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.15576354
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.06745195
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.75560614
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.75043119
13PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.66820541
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.64614751
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.57922279
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.57883372
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53797922
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.45275267
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.42125182
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37118816
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36330905
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35206638
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29956728
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29417544
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.26938316
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25450714
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22894590
28DCP1A_22483619_ChIP-Seq_HELA_Human2.20947778
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20436032
30PCGF2_27294783_Chip-Seq_ESCs_Mouse2.17621295
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17409345
32FOXP3_21729870_ChIP-Seq_TREG_Human2.17363512
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14245617
34IRF8_27001747_Chip-Seq_BMDM_Mouse2.11401363
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09338415
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02072543
37TAF15_26573619_Chip-Seq_HEK293_Human2.01644308
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01308939
39FUS_26573619_Chip-Seq_HEK293_Human1.98199349
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.92955007
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91574192
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.91353395
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89015235
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.86139411
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83998991
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.80523592
47ZNF274_21170338_ChIP-Seq_K562_Hela1.78342924
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74334455
49GABP_19822575_ChIP-Seq_HepG2_Human1.70280694
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68652634
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63328820
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62033997
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61688774
54RUNX_20019798_ChIP-Seq_JUKART_Human1.58317739
55ELK1_19687146_ChIP-ChIP_HELA_Human1.57944374
56MYB_26560356_Chip-Seq_TH2_Human1.57717538
57TTF2_22483619_ChIP-Seq_HELA_Human1.57428929
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.57097524
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56949764
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56065983
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.55723805
62HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55023184
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54491133
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54402395
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.54320321
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.53109920
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52548313
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.51904521
69P53_22387025_ChIP-Seq_ESCs_Mouse1.51834220
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51034785
71EWS_26573619_Chip-Seq_HEK293_Human1.50964753
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50666535
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48180681
74P300_18555785_Chip-Seq_ESCs_Mouse1.48126049
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48012104
76AR_21909140_ChIP-Seq_LNCAP_Human1.47889971
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.47217003
78P300_19829295_ChIP-Seq_ESCs_Human1.46326240
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44969339
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.44114681
81E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43520965
82ER_23166858_ChIP-Seq_MCF-7_Human1.42896473
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.41770994
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41450840
85SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40946999
86NMYC_18555785_Chip-Seq_ESCs_Mouse1.37971941
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37424776
88SPI1_23547873_ChIP-Seq_NB4_Human1.37257128
89RUNX1_27457419_Chip-Seq_LIVER_Mouse1.36185467
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.36157629
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.35931757
92EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35199312
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.32640540
94GBX2_23144817_ChIP-Seq_PC3_Human1.32539486
95TFEB_21752829_ChIP-Seq_HELA_Human1.30082466
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28811475
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28614843
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28243839
99* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27568282
100MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27310196
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26601178
102MYB_26560356_Chip-Seq_TH1_Human1.25821872
103XRN2_22483619_ChIP-Seq_HELA_Human1.24384406
104KDM5A_27292631_Chip-Seq_BREAST_Human1.23452886
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23291063
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23077434
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21294693
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21230336
109MYC_18940864_ChIP-ChIP_HL60_Human1.21025676
110MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20967165
111CRX_20693478_ChIP-Seq_RETINA_Mouse1.20771272
112SMAD1_18555785_Chip-Seq_ESCs_Mouse1.20509787
113PU1_27457419_Chip-Seq_LIVER_Mouse1.20132624
114ZFX_18555785_Chip-Seq_ESCs_Mouse1.17972758
115HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17224369
116VDR_22108803_ChIP-Seq_LS180_Human1.15756393
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15039945
118GATA3_26560356_Chip-Seq_TH2_Human1.14656770
119SALL4_22934838_ChIP-ChIP_CD34+_Human1.14518650
120VDR_23849224_ChIP-Seq_CD4+_Human1.12853171
121IGF1R_20145208_ChIP-Seq_DFB_Human1.12731217
122MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12244681
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11763086
124CTCF_18555785_Chip-Seq_ESCs_Mouse1.11301224
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10798039
126RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.09749589
127KLF4_18555785_Chip-Seq_ESCs_Mouse1.09560359
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08743434
129MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07491065
130ESRRB_18555785_Chip-Seq_ESCs_Mouse1.07301630
131PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06044563
132GATA3_27048872_Chip-Seq_THYMUS_Human1.05416452
133ELK1_22589737_ChIP-Seq_MCF10A_Human1.03479222
134CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03427810
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03183673
136GABP_17652178_ChIP-ChIP_JURKAT_Human1.03006678
137ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02740331
138SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02431214
139IRF1_19129219_ChIP-ChIP_H3396_Human1.02407473
140E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01398419
141MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00282315
142SMAD4_21799915_ChIP-Seq_A2780_Human0.99854464
143TAL1_26923725_Chip-Seq_HPCs_Mouse0.99842646
144GATA1_22025678_ChIP-Seq_K562_Human0.98541708
145SRF_21415370_ChIP-Seq_HL-1_Mouse0.98383979
146CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97461691
147PU_27001747_Chip-Seq_BMDM_Mouse0.97408592
148EGR1_19374776_ChIP-ChIP_THP-1_Human0.97234399
149IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96617633
150CBP_20019798_ChIP-Seq_JUKART_Human0.96617633
151PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95670368
152FLI1_21867929_ChIP-Seq_TH2_Mouse0.94137703
153ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94132605
154ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92796005
155CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92791781
156BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91488715
157ELF5_23300383_ChIP-Seq_T47D_Human0.91396808
158HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91223459
159CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89464610
160EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89336969
161TP53_22573176_ChIP-Seq_HFKS_Human0.88371061
162CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88342168
163RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85847619
164SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81610574
165POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79487484
166TP63_19390658_ChIP-ChIP_HaCaT_Human0.78960821
167SOX17_20123909_ChIP-Seq_XEN_Mouse0.78704836
168CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.78194593
169RBPJ_21746931_ChIP-Seq_IB4_Human0.78129401
170SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76201036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.51281501
2MP0005671_abnormal_response_to3.70544768
3MP0010094_abnormal_chromosome_stability3.58999419
4MP0003693_abnormal_embryo_hatching3.34649899
5MP0004957_abnormal_blastocyst_morpholog3.26533349
6MP0002009_preneoplasia3.11500302
7MP0001790_abnormal_immune_system2.98674883
8MP0005387_immune_system_phenotype2.98674883
9MP0008995_early_reproductive_senescence2.88944325
10MP0003111_abnormal_nucleus_morphology2.87599866
11MP0003183_abnormal_peptide_metabolism2.85529415
12MP0009785_altered_susceptibility_to2.82710866
13MP0000685_abnormal_immune_system2.79866677
14MP0000372_irregular_coat_pigmentation2.76818900
15MP0003718_maternal_effect2.72999607
16MP0003763_abnormal_thymus_physiology2.70360100
17MP0004147_increased_porphyrin_level2.70223500
18MP0001800_abnormal_humoral_immune2.69411492
19MP0005000_abnormal_immune_tolerance2.68432091
20MP0002166_altered_tumor_susceptibility2.66809872
21MP0002148_abnormal_hypersensitivity_rea2.60287461
22MP0003077_abnormal_cell_cycle2.58315716
23MP0005310_abnormal_salivary_gland2.50435809
24MP0002723_abnormal_immune_serum2.49889295
25MP0006082_CNS_inflammation2.48596746
26MP0002452_abnormal_antigen_presenting2.44822994
27MP0005408_hypopigmentation2.44612715
28MP0003786_premature_aging2.39527892
29MP0002006_tumorigenesis2.35218507
30MP0002420_abnormal_adaptive_immunity2.32423323
31MP0001819_abnormal_immune_cell2.32001911
32MP0003806_abnormal_nucleotide_metabolis2.24337007
33MP0008007_abnormal_cellular_replicative2.18634828
34MP0005025_abnormal_response_to2.17091146
35MP0002132_abnormal_respiratory_system2.15731507
36MP0002419_abnormal_innate_immunity2.15175021
37MP0004510_myositis2.06626348
38MP0006036_abnormal_mitochondrial_physio2.03559925
39MP0008877_abnormal_DNA_methylation2.01335362
40MP0006035_abnormal_mitochondrial_morpho1.95842582
41MP0003436_decreased_susceptibility_to1.94519605
42MP0005410_abnormal_fertilization1.94352184
43MP0003724_increased_susceptibility_to1.94142847
44MP0002398_abnormal_bone_marrow1.93084131
45MP0000716_abnormal_immune_system1.90329373
46MP0003656_abnormal_erythrocyte_physiolo1.88610714
47MP0001188_hyperpigmentation1.83679325
48MP0008932_abnormal_embryonic_tissue1.80218841
49MP0003221_abnormal_cardiomyocyte_apopto1.79221437
50MP0001853_heart_inflammation1.78296315
51MP0001986_abnormal_taste_sensitivity1.76067373
52MP0008057_abnormal_DNA_replication1.74826318
53MP0003195_calcinosis1.63029821
54MP0000569_abnormal_digit_pigmentation1.60953926
55MP0003787_abnormal_imprinting1.60125732
56MP0002876_abnormal_thyroid_physiology1.56975797
57MP0002405_respiratory_system_inflammati1.51525918
58MP0000689_abnormal_spleen_morphology1.50452597
59MP0003950_abnormal_plasma_membrane1.49556715
60MP0010307_abnormal_tumor_latency1.48990750
61MP0005451_abnormal_body_composition1.47727547
62MP0002429_abnormal_blood_cell1.46885462
63MP0005379_endocrine/exocrine_gland_phen1.45846077
64MP0002210_abnormal_sex_determination1.43969452
65MP0001697_abnormal_embryo_size1.43450022
66MP0002722_abnormal_immune_system1.41079909
67MP0000703_abnormal_thymus_morphology1.39340505
68MP0005464_abnormal_platelet_physiology1.37475120
69MP0000015_abnormal_ear_pigmentation1.36826358
70MP0005367_renal/urinary_system_phenotyp1.36291115
71MP0000516_abnormal_urinary_system1.36291115
72MP0001845_abnormal_inflammatory_respons1.35943965
73MP0003941_abnormal_skin_development1.33889908
74MP0009697_abnormal_copulation1.32130011
75MP0002396_abnormal_hematopoietic_system1.31618794
76MP0003186_abnormal_redox_activity1.31532717
77MP0005646_abnormal_pituitary_gland1.31523846
78MP0002138_abnormal_hepatobiliary_system1.31377284
79MP0003567_abnormal_fetal_cardiomyocyte1.30685497
80MP0002837_dystrophic_cardiac_calcinosis1.29085153
81MP0008260_abnormal_autophagy1.27214763
82MP0000350_abnormal_cell_proliferation1.23297049
83MP0004233_abnormal_muscle_weight1.22223712
84MP0000653_abnormal_sex_gland1.22050830
85MP0008469_abnormal_protein_level1.15670329
86MP0001145_abnormal_male_reproductive1.15217422
87MP0010155_abnormal_intestine_physiology1.13539139
88MP0009764_decreased_sensitivity_to1.13534381
89MP0002933_joint_inflammation1.13421142
90MP0005645_abnormal_hypothalamus_physiol1.13137549
91MP0001873_stomach_inflammation1.12933318
92MP0003866_abnormal_defecation1.10711443
93MP0000313_abnormal_cell_death1.09875123
94MP0002163_abnormal_gland_morphology1.08768323
95MP0004264_abnormal_extraembryonic_tissu1.07882560
96MP0003448_altered_tumor_morphology1.07126083
97MP0004808_abnormal_hematopoietic_stem1.07088006
98MP0001672_abnormal_embryogenesis/_devel1.06556423
99MP0005380_embryogenesis_phenotype1.06556423
100MP0001501_abnormal_sleep_pattern1.04690568
101MP0005075_abnormal_melanosome_morpholog1.04571733
102MP0000358_abnormal_cell_content/1.03637301
103MP0001730_embryonic_growth_arrest1.03567750
104MP0002693_abnormal_pancreas_physiology1.01795233
105MP0005395_other_phenotype0.99717989
106MP0001919_abnormal_reproductive_system0.98848088
107MP0010386_abnormal_urinary_bladder0.98722854
108MP0001905_abnormal_dopamine_level0.98182573
109MP0002088_abnormal_embryonic_growth/wei0.97924631
110MP0003984_embryonic_growth_retardation0.97904760
111MP0005174_abnormal_tail_pigmentation0.97109800
112MP0005332_abnormal_amino_acid0.96415337
113MP0002080_prenatal_lethality0.95306516
114MP0002161_abnormal_fertility/fecundity0.95061829
115MP0002277_abnormal_respiratory_mucosa0.92127760
116MP0005266_abnormal_metabolism0.91432331
117MP0003121_genomic_imprinting0.91332075
118MP0000427_abnormal_hair_cycle0.90538504
119MP0001533_abnormal_skeleton_physiology0.89785364
120MP0008789_abnormal_olfactory_epithelium0.89709459
121MP0008775_abnormal_heart_ventricle0.89582758
122MP0000647_abnormal_sebaceous_gland0.88604323
123MP0001727_abnormal_embryo_implantation0.86740075
124MP0001661_extended_life_span0.84924404
125MP0000371_diluted_coat_color0.84731782
126MP0005389_reproductive_system_phenotype0.84109742
127MP0002086_abnormal_extraembryonic_tissu0.83924893
128MP0002102_abnormal_ear_morphology0.82653266
129MP0004215_abnormal_myocardial_fiber0.82618346
130MP0001119_abnormal_female_reproductive0.82412065
131MP0002095_abnormal_skin_pigmentation0.82085288
132MP0001764_abnormal_homeostasis0.81861547
133MP0009333_abnormal_splenocyte_physiolog0.80990579
134MP0002638_abnormal_pupillary_reflex0.80452641
135MP0004947_skin_inflammation0.80337976
136MP0002019_abnormal_tumor_incidence0.80273641
137MP0005376_homeostasis/metabolism_phenot0.79897005
138MP0001929_abnormal_gametogenesis0.79811583
139MP0003698_abnormal_male_reproductive0.79638571
140MP0001984_abnormal_olfaction0.79302694
141MP0002160_abnormal_reproductive_system0.78400148
142MP0002938_white_spotting0.78143216
143MP0002998_abnormal_bone_remodeling0.77333026
144MP0001529_abnormal_vocalization0.77064292
145MP0006072_abnormal_retinal_apoptosis0.76970174
146MP0001545_abnormal_hematopoietic_system0.74813731
147MP0005397_hematopoietic_system_phenotyp0.74813731
148MP0004084_abnormal_cardiac_muscle0.74367516
149MP0004381_abnormal_hair_follicle0.73780391
150MP0005499_abnormal_olfactory_system0.73146810
151MP0005394_taste/olfaction_phenotype0.73146810
152MP0005551_abnormal_eye_electrophysiolog0.70669762
153MP0005253_abnormal_eye_physiology0.69695848
154MP0005084_abnormal_gallbladder_morpholo0.68276499
155MP0001191_abnormal_skin_condition0.68140516
156MP0003879_abnormal_hair_cell0.67499209
157MP0003943_abnormal_hepatobiliary_system0.67452916
158MP0000858_altered_metastatic_potential0.67398302
159MP0008058_abnormal_DNA_repair0.67393185
160MP0009046_muscle_twitch0.65780181
161MP0000681_abnormal_thyroid_gland0.65026263
162MP0005636_abnormal_mineral_homeostasis0.63681317
163MP0003699_abnormal_female_reproductive0.63271945
164MP0004197_abnormal_fetal_growth/weight/0.62940504
165MP0003828_pulmonary_edema0.62476832
166MP0002735_abnormal_chemical_nociception0.60141700
167MP0000465_gastrointestinal_hemorrhage0.59353434
168MP0001186_pigmentation_phenotype0.58306895
169MP0006292_abnormal_olfactory_placode0.57606154
170MP0001348_abnormal_lacrimal_gland0.56295395
171MP0002877_abnormal_melanocyte_morpholog0.56149128
172MP0002928_abnormal_bile_duct0.55604428
173MP0006276_abnormal_autonomic_nervous0.54957917
174MP0005535_abnormal_body_temperature0.54439107
175MP0001502_abnormal_circadian_rhythm0.52743931

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)4.13811698
2Eczematoid dermatitis (HP:0000976)3.83167875
3Stomatitis (HP:0010280)3.73057962
4Recurrent fungal infections (HP:0002841)3.63694840
5Recurrent abscess formation (HP:0002722)3.58810641
6Recurrent cutaneous fungal infections (HP:0011370)3.51405755
7Chronic mucocutaneous candidiasis (HP:0002728)3.51405755
8Acute encephalopathy (HP:0006846)3.46490254
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.45741007
10Absent/shortened dynein arms (HP:0200106)3.45741007
11Recurrent bacterial skin infections (HP:0005406)3.41247109
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.36446832
13Increased serum pyruvate (HP:0003542)3.36129215
14Abnormality of T cell number (HP:0011839)3.33829215
15Recurrent viral infections (HP:0004429)3.32172207
16Panhypogammaglobulinemia (HP:0003139)3.22202144
17Acute necrotizing encephalopathy (HP:0006965)3.20669244
18Abnormality of glycolysis (HP:0004366)3.19324850
19Recurrent bronchitis (HP:0002837)3.17739474
20IgG deficiency (HP:0004315)3.17225786
21Abnormality of chromosome stability (HP:0003220)3.14713770
22Medial flaring of the eyebrow (HP:0010747)3.13997724
23T lymphocytopenia (HP:0005403)3.07140582
24Agammaglobulinemia (HP:0004432)3.03763582
25Lipid accumulation in hepatocytes (HP:0006561)2.98848121
26Mediastinal lymphadenopathy (HP:0100721)2.97198015
27Abnormal delayed hypersensitivity skin test (HP:0002963)2.97146235
28Recurrent sinusitis (HP:0011108)2.95302421
29Increased hepatocellular lipid droplets (HP:0006565)2.94781564
30Chronic sinusitis (HP:0011109)2.94576933
31Optic neuritis (HP:0100653)2.92919057
32Retrobulbar optic neuritis (HP:0100654)2.92919057
33Hypothermia (HP:0002045)2.90600204
34Abnormal mitochondria in muscle tissue (HP:0008316)2.89139503
35Abnormality of alanine metabolism (HP:0010916)2.85163142
36Hyperalaninemia (HP:0003348)2.85163142
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.85163142
38Progressive macrocephaly (HP:0004481)2.85012186
39Recurrent skin infections (HP:0001581)2.84841028
40Abnormal respiratory motile cilium physiology (HP:0012261)2.83014260
41Abnormality of the preputium (HP:0100587)2.82504158
42Abnormal respiratory motile cilium morphology (HP:0005938)2.81645085
43Abnormal respiratory epithelium morphology (HP:0012253)2.81645085
44Pancreatic fibrosis (HP:0100732)2.79020676
45Volvulus (HP:0002580)2.76149974
46Septate vagina (HP:0001153)2.73525581
47Increased CSF lactate (HP:0002490)2.73288392
48Abnormal ciliary motility (HP:0012262)2.72195905
49Severe combined immunodeficiency (HP:0004430)2.71491292
50Abnormal gallbladder physiology (HP:0012438)2.71233257
51Cholecystitis (HP:0001082)2.71233257
52Vasculitis (HP:0002633)2.71026154
53Meckel diverticulum (HP:0002245)2.70526249
54Thyroiditis (HP:0100646)2.69727171
55Congenital primary aphakia (HP:0007707)2.69179519
56Abnormality of T cells (HP:0002843)2.66102458
57Abnormal hair whorl (HP:0010721)2.64534160
58Chronic otitis media (HP:0000389)2.63741213
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.63612035
60Gait imbalance (HP:0002141)2.60337087
61Autoimmune thrombocytopenia (HP:0001973)2.59711778
62Abnormality of the ileum (HP:0001549)2.57488155
63Nephrogenic diabetes insipidus (HP:0009806)2.54974434
64Birth length less than 3rd percentile (HP:0003561)2.54457596
65Eosinophilia (HP:0001880)2.54265279
66Small intestinal stenosis (HP:0012848)2.51466068
67Duodenal stenosis (HP:0100867)2.51466068
68Prostate neoplasm (HP:0100787)2.51150620
69Recurrent pneumonia (HP:0006532)2.49967422
70Bronchitis (HP:0012387)2.49537784
71Pancreatic islet-cell hyperplasia (HP:0004510)2.48454277
72Pulmonary infiltrates (HP:0002113)2.47608397
73Increased serum lactate (HP:0002151)2.46888671
74Constricted visual fields (HP:0001133)2.46499182
75Rhinitis (HP:0012384)2.44510651
76Abnormality of T cell physiology (HP:0011840)2.43909749
77Myelodysplasia (HP:0002863)2.43900163
78Myositis (HP:0100614)2.42720746
79Abnormality of methionine metabolism (HP:0010901)2.42106406
80Granulocytopenia (HP:0001913)2.41000135
81Chronic diarrhea (HP:0002028)2.40122718
82Fair hair (HP:0002286)2.38755642
83Mitochondrial inheritance (HP:0001427)2.38526269
84Meningitis (HP:0001287)2.38066930
85Abnormality of eosinophils (HP:0001879)2.37974805
86Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37912883
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37912883
88Bronchiectasis (HP:0002110)2.37606536
89Abnormality of the anterior horn cell (HP:0006802)2.35826847
90Degeneration of anterior horn cells (HP:0002398)2.35826847
91IgM deficiency (HP:0002850)2.33874161
92B lymphocytopenia (HP:0010976)2.33782243
93Abnormality of B cell number (HP:0010975)2.33782243
94Hypergammaglobulinemia (HP:0010702)2.31406045
95True hermaphroditism (HP:0010459)2.29924742
96Methylmalonic acidemia (HP:0002912)2.29843301
973-Methylglutaconic aciduria (HP:0003535)2.29683614
98Poikilocytosis (HP:0004447)2.29465128
99Dyschromatopsia (HP:0007641)2.26883604
100Hepatic necrosis (HP:0002605)2.25840471
101Gingivitis (HP:0000230)2.21874506
102Cerebral edema (HP:0002181)2.19785758
103Orchitis (HP:0100796)2.19282976
104Hepatocellular necrosis (HP:0001404)2.18493577
105Osteomyelitis (HP:0002754)2.17187314
106Abnormality of macrophages (HP:0004311)2.16513330
107Poor coordination (HP:0002370)2.16050857
108Combined immunodeficiency (HP:0005387)2.15702291
109Abnormal lung lobation (HP:0002101)2.15513082
110Encephalitis (HP:0002383)2.15234364
111Nephronophthisis (HP:0000090)2.13510179
112Pancreatic cysts (HP:0001737)2.13115747
113Abnormality of serum amino acid levels (HP:0003112)2.11193709
114Alveolar cell carcinoma (HP:0006519)2.09963214
115IgA deficiency (HP:0002720)2.08892535
116Cutaneous melanoma (HP:0012056)2.08741708
117Nasal polyposis (HP:0100582)2.08080745
118Abnormality of the duodenum (HP:0002246)2.07833095
119Upper limb muscle weakness (HP:0003484)2.07709953
120Lactic acidosis (HP:0003128)2.07127209
121Exercise-induced muscle cramps (HP:0003710)2.07023284
122Renal Fanconi syndrome (HP:0001994)2.06798104
123Abnormality of DNA repair (HP:0003254)2.06558562
124Reticulocytosis (HP:0001923)2.06315526
125Keratoconjunctivitis (HP:0001096)2.05613181
126Obstructive lung disease (HP:0006536)2.05179762
127Chronic obstructive pulmonary disease (HP:0006510)2.05179762
128Microvesicular hepatic steatosis (HP:0001414)2.04988153
129Abnormality of the prostate (HP:0008775)2.04930831
130Acanthocytosis (HP:0001927)2.04821576
131Hypoplasia of the thymus (HP:0000778)2.01769003
132Abnormal spermatogenesis (HP:0008669)2.01748409
133Lymphoma (HP:0002665)2.01589924
134Autoimmune hemolytic anemia (HP:0001890)2.01584380
135Recurrent gram-negative bacterial infections (HP:0005420)2.01195188
136Abnormality of the heme biosynthetic pathway (HP:0010472)2.01149323
137Hyperglycinemia (HP:0002154)2.00912076
138Recurrent lower respiratory tract infections (HP:0002783)2.00160319
139Protruding tongue (HP:0010808)1.99889862
140Elevated erythrocyte sedimentation rate (HP:0003565)1.99267276
141Abnormality of cells of the lymphoid lineage (HP:0012140)1.99226703
142Lymphopenia (HP:0001888)1.98342252
143Nephroblastoma (Wilms tumor) (HP:0002667)1.96824991
144Tubulointerstitial nephritis (HP:0001970)1.95987995
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95968275
146Generalized hypopigmentation of hair (HP:0011358)1.95925055
147Abnormality of homocysteine metabolism (HP:0010919)1.95423273
148Homocystinuria (HP:0002156)1.95423273
149Leukocytosis (HP:0001974)1.94258796
150Rectovaginal fistula (HP:0000143)1.94207739
151Rectal fistula (HP:0100590)1.94207739
152Dry hair (HP:0011359)1.94064089
153Attenuation of retinal blood vessels (HP:0007843)1.93588629
154Keratoconjunctivitis sicca (HP:0001097)1.93118706
155Neutropenia (HP:0001875)1.92959001
156Horizontal nystagmus (HP:0000666)1.92652884
157Embryonal renal neoplasm (HP:0011794)1.92006591
158Sloping forehead (HP:0000340)1.90800086
159Abnormal protein glycosylation (HP:0012346)1.89888856
160Abnormal glycosylation (HP:0012345)1.89888856
161Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89888856
162Abnormal protein N-linked glycosylation (HP:0012347)1.89888856
163Abnormality of endocrine pancreas physiology (HP:0012093)1.89663227
164Abnormality of the pancreatic islet cells (HP:0006476)1.89663227
165Squamous cell carcinoma (HP:0002860)1.89414885
166Abnormality of the renal medulla (HP:0100957)1.89223210
167Chromsome breakage (HP:0040012)1.89219777
168Hypoglycemic coma (HP:0001325)1.88811839
169Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88252754
170Short middle phalanx of the 5th finger (HP:0004220)1.86114461
171Thyroid carcinoma (HP:0002890)1.84763443
172Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83988924
173Methylmalonic aciduria (HP:0012120)1.82887331
174Limb hypertonia (HP:0002509)1.82448298
175Megaloblastic anemia (HP:0001889)1.82169971
176Papillary thyroid carcinoma (HP:0002895)1.80884612
177Degeneration of the lateral corticospinal tracts (HP:0002314)1.80795252
178Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80795252
179Type I transferrin isoform profile (HP:0003642)1.80540337
180Azoospermia (HP:0000027)1.80063287
181Rhabdomyosarcoma (HP:0002859)1.76476401
182Genital tract atresia (HP:0001827)1.76360244
183Astigmatism (HP:0000483)1.75230625
184Leukodystrophy (HP:0002415)1.71420018
185Aplasia/Hypoplasia of the earlobes (HP:0009906)1.70985663
186Vaginal fistula (HP:0004320)1.70518331
187Vaginal atresia (HP:0000148)1.68219485
188Generalized aminoaciduria (HP:0002909)1.67133414
189Respiratory difficulties (HP:0002880)1.66909151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.08800313
2MAP3K143.24785508
3BUB12.90063908
4IRAK42.88794475
5TSSK62.78168677
6MST42.70277441
7MAP4K12.69416890
8IRAK32.59504722
9BRSK22.56810698
10IKBKE2.41411903
11JAK32.36052324
12TRIM282.29488262
13WEE12.25646977
14TEC2.22226192
15TYK22.01953206
16TTK2.00908331
17SIK31.92294568
18NEK11.83116788
19MAP3K131.81585651
20IRAK11.80136476
21ADRBK21.72211637
22BMPR21.71814384
23MAP3K121.71724189
24MAP4K21.68236773
25KIT1.65968555
26PLK31.60861411
27CDC71.58601807
28NLK1.56158702
29RAF11.50451657
30ITK1.49844607
31RIPK41.45639419
32NUAK11.44831767
33MKNK21.44350168
34MAP3K21.42262223
35LATS11.39696843
36JAK11.38963473
37STK38L1.36360444
38STK31.35716459
39EPHB11.35509525
40GRK71.33405338
41SYK1.31069557
42MAP2K71.28018819
43YES11.24595755
44IKBKB1.23870769
45BTK1.22034807
46CDK121.20614297
47PRPF4B1.20453837
48TBK11.20368836
49MKNK11.20089059
50CASK1.19477571
51BCR1.16665534
52TNIK1.13283293
53EIF2AK31.12763139
54TAOK31.11009461
55LCK1.06167471
56CCNB11.04284408
57ZAP701.03912367
58FGFR41.02822714
59AKT31.01897869
60KSR21.01012899
61RPS6KA41.00791635
62KSR11.00023338
63ATR0.99797332
64PLK10.98926868
65TNK20.98714446
66MAPK150.97433836
67PRKCQ0.95931869
68IRAK20.95643758
69TGFBR20.93207842
70EIF2AK20.93044102
71FGFR30.92523046
72CHEK20.90829719
73BMPR1B0.90074867
74STK160.89804754
75PBK0.88805715
76BRSK10.85800624
77CHUK0.84202321
78EIF2AK10.83257594
79ATM0.82510055
80CLK10.80294321
81MAP3K40.79203848
82RPS6KA50.78134918
83CDK70.77518425
84PIM10.76456743
85LYN0.76323693
86CDK30.76271117
87CDK190.76191916
88NEK90.74006661
89VRK20.73301894
90ZAK0.73014856
91GRK60.72332190
92PNCK0.72244754
93BRD40.71671710
94SRPK10.69782068
95TAF10.69689198
96SCYL20.68239693
97CHEK10.68076414
98STK240.68008535
99CSK0.67919158
100FGFR10.66366523
101EPHA30.65887955
102MARK30.65462319
103VRK10.63200967
104AURKB0.62898494
105CSF1R0.62753308
106NEK60.62509605
107CSNK2A20.58330275
108FES0.57011016
109PIM20.56902188
110NME10.56330035
111PLK40.56327582
112HCK0.54497018
113INSRR0.53827298
114PIK3CG0.53796302
115PASK0.53617460
116ERBB30.53243121
117SIK20.51900476
118GRK50.50539035
119BRAF0.50270140
120PRKCE0.49768443
121STK40.48769908
122PLK20.48650361
123WNK10.48629381
124CSNK2A10.48531576
125HIPK20.47741104
126CSNK1G30.47169678
127PDK40.46892215
128PDK30.46892215
129OXSR10.46470272
130FRK0.45993931
131NTRK30.45915536
132SGK20.45808616
133CSNK1A1L0.44151407
134FLT30.43834903
135CDK10.42935232
136ARAF0.42655143
137ACVR1B0.41691197
138DYRK30.41325785
139PDK20.41102454
140CDK20.41026806
141CDK80.39393791
142STK100.37777813
143DYRK1A0.37115492
144CSNK1G10.37033209
145NEK20.34153464
146STK390.33200032
147MATK0.32898592
148LATS20.32418515
149CSNK1E0.31192654
150ERBB40.27539584
151MAP3K80.26089510
152RPS6KB10.25955184

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.44459882
2Primary immunodeficiency_Homo sapiens_hsa053403.44263137
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25289765
4Allograft rejection_Homo sapiens_hsa053303.05091606
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.04695456
6Graft-versus-host disease_Homo sapiens_hsa053322.97865257
7DNA replication_Homo sapiens_hsa030302.91404711
8Protein export_Homo sapiens_hsa030602.77281601
9RNA transport_Homo sapiens_hsa030132.68937320
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.57772116
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.52272937
12Autoimmune thyroid disease_Homo sapiens_hsa053202.33424593
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.30283774
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29239356
15One carbon pool by folate_Homo sapiens_hsa006702.23178672
16Propanoate metabolism_Homo sapiens_hsa006402.19182288
17Type I diabetes mellitus_Homo sapiens_hsa049402.17287858
18Measles_Homo sapiens_hsa051622.11260865
19Rheumatoid arthritis_Homo sapiens_hsa053232.04868518
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95386970
21Cell cycle_Homo sapiens_hsa041101.94706626
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.92652153
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91777082
24Leishmaniasis_Homo sapiens_hsa051401.90472350
25Asthma_Homo sapiens_hsa053101.78226475
26Antigen processing and presentation_Homo sapiens_hsa046121.77766850
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77340517
28Hematopoietic cell lineage_Homo sapiens_hsa046401.77111334
29mRNA surveillance pathway_Homo sapiens_hsa030151.64636918
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59319093
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58652541
32Collecting duct acid secretion_Homo sapiens_hsa049661.56324259
33T cell receptor signaling pathway_Homo sapiens_hsa046601.51393056
34Selenocompound metabolism_Homo sapiens_hsa004501.49902072
35Legionellosis_Homo sapiens_hsa051341.48239610
36Herpes simplex infection_Homo sapiens_hsa051681.47031509
37African trypanosomiasis_Homo sapiens_hsa051431.46983199
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43939655
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41665100
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.41661865
41Malaria_Homo sapiens_hsa051441.40640035
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39912454
43Osteoclast differentiation_Homo sapiens_hsa043801.37927463
44B cell receptor signaling pathway_Homo sapiens_hsa046621.36742122
45Pyrimidine metabolism_Homo sapiens_hsa002401.29407378
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27132109
47Non-homologous end-joining_Homo sapiens_hsa034501.26667305
48Steroid biosynthesis_Homo sapiens_hsa001001.25024242
49RNA degradation_Homo sapiens_hsa030181.24222880
50Influenza A_Homo sapiens_hsa051641.22678228
51Butanoate metabolism_Homo sapiens_hsa006501.22105122
52Oocyte meiosis_Homo sapiens_hsa041141.20622244
53Carbon metabolism_Homo sapiens_hsa012001.18041039
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16538517
55Tuberculosis_Homo sapiens_hsa051521.15411656
56Fatty acid elongation_Homo sapiens_hsa000621.14895012
57Ribosome_Homo sapiens_hsa030101.11658263
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.10285318
59Pertussis_Homo sapiens_hsa051331.09965818
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08385255
61Basal transcription factors_Homo sapiens_hsa030221.07795531
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06902836
63Proteasome_Homo sapiens_hsa030501.06490289
64TNF signaling pathway_Homo sapiens_hsa046681.05156937
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03119021
66Circadian rhythm_Homo sapiens_hsa047101.02559253
67Hepatitis B_Homo sapiens_hsa051611.01157648
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00897499
69Chemokine signaling pathway_Homo sapiens_hsa040620.95864609
70Oxidative phosphorylation_Homo sapiens_hsa001900.93112518
71Folate biosynthesis_Homo sapiens_hsa007900.92797678
72Phototransduction_Homo sapiens_hsa047440.91387453
73Phagosome_Homo sapiens_hsa041450.90309884
74Vibrio cholerae infection_Homo sapiens_hsa051100.88695885
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87438160
76Toxoplasmosis_Homo sapiens_hsa051450.87143830
77Pyruvate metabolism_Homo sapiens_hsa006200.86277606
78Homologous recombination_Homo sapiens_hsa034400.85614755
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.82102488
80Biosynthesis of amino acids_Homo sapiens_hsa012300.81565513
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81087672
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80954716
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80947543
84Vitamin B6 metabolism_Homo sapiens_hsa007500.76957154
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76460162
86Epstein-Barr virus infection_Homo sapiens_hsa051690.75995571
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75137882
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75037459
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74984932
90Olfactory transduction_Homo sapiens_hsa047400.73048563
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72097704
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.71982771
93Hepatitis C_Homo sapiens_hsa051600.71559219
94Taste transduction_Homo sapiens_hsa047420.70012874
95Serotonergic synapse_Homo sapiens_hsa047260.67473335
96Fatty acid metabolism_Homo sapiens_hsa012120.67268652
97Nicotine addiction_Homo sapiens_hsa050330.65698176
98Regulation of autophagy_Homo sapiens_hsa041400.65049513
99Fanconi anemia pathway_Homo sapiens_hsa034600.64120658
100Salmonella infection_Homo sapiens_hsa051320.61998995
101Viral myocarditis_Homo sapiens_hsa054160.60071665
102Morphine addiction_Homo sapiens_hsa050320.59995016
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59382781
104Alzheimers disease_Homo sapiens_hsa050100.59253337
105Metabolic pathways_Homo sapiens_hsa011000.57614942
106Nucleotide excision repair_Homo sapiens_hsa034200.56935565
107Shigellosis_Homo sapiens_hsa051310.56147168
108Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55186320
109Sphingolipid metabolism_Homo sapiens_hsa006000.54840809
110N-Glycan biosynthesis_Homo sapiens_hsa005100.54321678
111Amphetamine addiction_Homo sapiens_hsa050310.54248045
112Apoptosis_Homo sapiens_hsa042100.53050457
113RNA polymerase_Homo sapiens_hsa030200.51980520
114Base excision repair_Homo sapiens_hsa034100.50971685
115Huntingtons disease_Homo sapiens_hsa050160.49115884
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48352403
117Glutathione metabolism_Homo sapiens_hsa004800.48252653
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47010380
119HIF-1 signaling pathway_Homo sapiens_hsa040660.45769343
120Spliceosome_Homo sapiens_hsa030400.45743259
121Parkinsons disease_Homo sapiens_hsa050120.45481026
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45380471
123Renin secretion_Homo sapiens_hsa049240.45248303
124Fatty acid biosynthesis_Homo sapiens_hsa000610.42540015
125Viral carcinogenesis_Homo sapiens_hsa052030.42422858
126Ether lipid metabolism_Homo sapiens_hsa005650.41083229
127Pancreatic cancer_Homo sapiens_hsa052120.37849646
128Long-term potentiation_Homo sapiens_hsa047200.37822230
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36451027
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34570186
131Acute myeloid leukemia_Homo sapiens_hsa052210.33080433
132Purine metabolism_Homo sapiens_hsa002300.32851846
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32309019
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32088223
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31968695
136Synaptic vesicle cycle_Homo sapiens_hsa047210.31274678
137HTLV-I infection_Homo sapiens_hsa051660.30286976
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.29611312
139Dorso-ventral axis formation_Homo sapiens_hsa043200.27939834
140p53 signaling pathway_Homo sapiens_hsa041150.27819669
141Other glycan degradation_Homo sapiens_hsa005110.27319001
142Prolactin signaling pathway_Homo sapiens_hsa049170.26472235
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25192520
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24878511
145Cocaine addiction_Homo sapiens_hsa050300.24244406
146MAPK signaling pathway_Homo sapiens_hsa040100.23623283
147FoxO signaling pathway_Homo sapiens_hsa040680.23421960
148Drug metabolism - other enzymes_Homo sapiens_hsa009830.22026981
149Thyroid cancer_Homo sapiens_hsa052160.21465554
150Peroxisome_Homo sapiens_hsa041460.19975269
151Cardiac muscle contraction_Homo sapiens_hsa042600.17584900
152Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17447068
153Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13935205
154Fructose and mannose metabolism_Homo sapiens_hsa000510.12143254
155Pentose phosphate pathway_Homo sapiens_hsa000300.11274387
156Primary bile acid biosynthesis_Homo sapiens_hsa001200.10915506
157mTOR signaling pathway_Homo sapiens_hsa041500.10859926
158Alcoholism_Homo sapiens_hsa050340.09010007
159Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05246502
160beta-Alanine metabolism_Homo sapiens_hsa004100.05166276
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.02534130
162Sulfur metabolism_Homo sapiens_hsa009200.01600604

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