LRIG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)5.06622848
2presynaptic membrane assembly (GO:0097105)4.73272004
3central nervous system myelination (GO:0022010)4.38498085
4axon ensheathment in central nervous system (GO:0032291)4.38498085
5presynaptic membrane organization (GO:0097090)4.18445938
6L-amino acid import (GO:0043092)3.99329602
7amino acid import (GO:0043090)3.92575357
8dermatan sulfate biosynthetic process (GO:0030208)3.83628786
9hemidesmosome assembly (GO:0031581)3.79065758
10astrocyte differentiation (GO:0048708)3.77913358
11photoreceptor cell differentiation (GO:0046530)3.72156961
12eye photoreceptor cell differentiation (GO:0001754)3.72156961
13alpha-linolenic acid metabolic process (GO:0036109)3.71108523
14positive regulation of fatty acid beta-oxidation (GO:0032000)3.68418821
15dermatan sulfate metabolic process (GO:0030205)3.58683270
16G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.54331987
17neuron cell-cell adhesion (GO:0007158)3.52554523
18positive regulation of fatty acid oxidation (GO:0046321)3.48156220
19protein heterotrimerization (GO:0070208)3.47046095
20locomotory exploration behavior (GO:0035641)3.35587619
21camera-type eye morphogenesis (GO:0048593)3.34440185
22sodium ion export (GO:0071436)3.34349499
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.33917456
24ovulation cycle (GO:0042698)3.33147032
25lateral sprouting from an epithelium (GO:0060601)3.30061144
26axonemal dynein complex assembly (GO:0070286)3.29790017
27regulation of fatty acid beta-oxidation (GO:0031998)3.27657153
28potassium ion homeostasis (GO:0055075)3.27557538
29vocalization behavior (GO:0071625)3.23318838
30apical protein localization (GO:0045176)3.20676116
31neuron projection regeneration (GO:0031102)3.18624477
32negative regulation of fatty acid transport (GO:2000192)3.18058295
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.17778423
34hyperosmotic salinity response (GO:0042538)3.12634445
35negative regulation of catenin import into nucleus (GO:0035414)3.05182019
36cerebellar granule cell differentiation (GO:0021707)3.03752091
37positive regulation of glycogen biosynthetic process (GO:0045725)3.02142960
38planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99907171
39negative regulation of smooth muscle cell migration (GO:0014912)2.99595656
40neuronal ion channel clustering (GO:0045161)2.97735372
41convergent extension (GO:0060026)2.96646745
42oligodendrocyte differentiation (GO:0048709)2.95605722
43astrocyte development (GO:0014002)2.95468499
44regulation of cholesterol homeostasis (GO:2000188)2.93700428
45regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89612833
46lung epithelium development (GO:0060428)2.88114269
47valine metabolic process (GO:0006573)2.86577987
48growth hormone receptor signaling pathway (GO:0060396)2.85675748
49low-density lipoprotein particle clearance (GO:0034383)2.84093966
50cGMP-mediated signaling (GO:0019934)2.83322996
51plasma membrane repair (GO:0001778)2.82263874
52Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.81619575
53positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.81530023
54negative regulation of sodium ion transport (GO:0010766)2.81380550
55chondroitin sulfate catabolic process (GO:0030207)2.81164799
56notochord development (GO:0030903)2.80772909
57regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.79927545
58cell migration involved in sprouting angiogenesis (GO:0002042)2.79183309
59regulation of fatty acid oxidation (GO:0046320)2.77288471
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.76218176
61neurotransmitter uptake (GO:0001504)2.74036728
62cytoskeletal anchoring at plasma membrane (GO:0007016)2.73080487
63developmental induction (GO:0031128)2.72561874
64regulation of sequestering of triglyceride (GO:0010889)2.71174932
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.70916360
66exploration behavior (GO:0035640)2.70724254
67cellular potassium ion homeostasis (GO:0030007)2.69626407
68one-carbon compound transport (GO:0019755)2.68379390
69white fat cell differentiation (GO:0050872)2.68269869
70cilium or flagellum-dependent cell motility (GO:0001539)2.68158063
71positive regulation of histone deacetylation (GO:0031065)2.67873029
72cellular response to cholesterol (GO:0071397)2.67113845
73regulation of establishment of planar polarity (GO:0090175)2.66576453
74ionotropic glutamate receptor signaling pathway (GO:0035235)2.66206415
75insulin-like growth factor receptor signaling pathway (GO:0048009)2.65729577
76regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.65556548
77neuron recognition (GO:0008038)2.65477182
78epithelial cell differentiation involved in prostate gland development (GO:0060742)2.65390465
79regulation of cardiac muscle cell contraction (GO:0086004)2.63109970
80appendage development (GO:0048736)2.62783185
81limb development (GO:0060173)2.62783185
82positive regulation of glucose import (GO:0046326)2.62574707
83asymmetric protein localization (GO:0008105)2.62247727
84cell-cell signaling involved in cell fate commitment (GO:0045168)2.62091239
85heart valve formation (GO:0003188)2.61861733
86regulation of inclusion body assembly (GO:0090083)2.61413248
87axonal fasciculation (GO:0007413)2.61022951
88hippo signaling (GO:0035329)2.60640230
89peptidyl-tyrosine autophosphorylation (GO:0038083)2.60379566
90positive regulation of fatty acid metabolic process (GO:0045923)2.60030303
91positive regulation of astrocyte differentiation (GO:0048711)2.58717075
92nephron tubule formation (GO:0072079)2.58607701
93branching involved in salivary gland morphogenesis (GO:0060445)2.56970677
94mechanosensory behavior (GO:0007638)2.55733029
95cilium movement (GO:0003341)2.55413594
96positive regulation of glycogen metabolic process (GO:0070875)2.55177117
97outer ear morphogenesis (GO:0042473)2.54808878
98establishment of nucleus localization (GO:0040023)2.53762546
99glial cell differentiation (GO:0010001)2.53152729
100myelination (GO:0042552)2.51908790
101neuromuscular junction development (GO:0007528)2.51372818
1024-hydroxyproline metabolic process (GO:0019471)2.51310230
103cellular response to sterol (GO:0036315)2.50564367
104regulation of p38MAPK cascade (GO:1900744)2.50544339
105auditory behavior (GO:0031223)2.50229405
106peripheral nervous system axon ensheathment (GO:0032292)2.50066983
107myelination in peripheral nervous system (GO:0022011)2.50066983
108positive regulation of triglyceride biosynthetic process (GO:0010867)2.50043309
109cellular sodium ion homeostasis (GO:0006883)2.48687830
110membrane assembly (GO:0071709)2.47597769
111linoleic acid metabolic process (GO:0043651)2.47592959
112positive regulation of p38MAPK cascade (GO:1900745)2.47589501
113otic vesicle formation (GO:0030916)2.47462267
114neuronal stem cell maintenance (GO:0097150)2.47420374
115regulation of cholesterol storage (GO:0010885)2.46461782
116regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46448427
117epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45886058
118cell communication by electrical coupling (GO:0010644)2.45650480
119ensheathment of neurons (GO:0007272)2.45591167
120axon ensheathment (GO:0008366)2.45591167
121apoptotic cell clearance (GO:0043277)2.45562910
122cell-substrate junction assembly (GO:0007044)2.45117626
123endodermal cell differentiation (GO:0035987)2.44908036
124neuromuscular process controlling balance (GO:0050885)2.44717950
125glial cell proliferation (GO:0014009)2.44520751
126positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.44050420
127regulation of actin filament-based movement (GO:1903115)2.43798448
128synaptic vesicle docking involved in exocytosis (GO:0016081)2.42313136
129establishment or maintenance of apical/basal cell polarity (GO:0035088)2.41628020
130establishment or maintenance of bipolar cell polarity (GO:0061245)2.41628020
131lens fiber cell development (GO:0070307)2.41530431
132response to auditory stimulus (GO:0010996)2.41346377
133polarized epithelial cell differentiation (GO:0030859)2.39518737
134cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.37742276
135positive regulation of glucose transport (GO:0010828)2.37614751
136skin morphogenesis (GO:0043589)2.37116473
137cellular response to growth hormone stimulus (GO:0071378)2.36745245
138desmosome organization (GO:0002934)2.36252566
139positive regulation of triglyceride metabolic process (GO:0090208)2.35721237
140triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.35706770
141cell communication involved in cardiac conduction (GO:0086065)2.34916094
142carnitine shuttle (GO:0006853)2.34859926
143basement membrane organization (GO:0071711)2.34443187
144type B pancreatic cell proliferation (GO:0044342)2.33109731
145negative regulation of smoothened signaling pathway (GO:0045879)2.33042228
146negative regulation of chondrocyte differentiation (GO:0032331)2.32967154
147regulation of glucose import in response to insulin stimulus (GO:2001273)2.32622539
148creatine metabolic process (GO:0006600)2.32514229
149regulation of triglyceride biosynthetic process (GO:0010866)2.32410511
150negative regulation of inclusion body assembly (GO:0090084)2.31793307
151collagen fibril organization (GO:0030199)2.30618404
152potassium ion import (GO:0010107)2.29136814
153regulation of glutamate receptor signaling pathway (GO:1900449)2.28560449
154digestive tract morphogenesis (GO:0048546)2.28419948
155regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.28402697
156paraxial mesoderm development (GO:0048339)2.27987577
157regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.27706525
158regulation of neuronal synaptic plasticity (GO:0048168)2.26544052
159cranial nerve development (GO:0021545)2.26369100
160regulation of hippo signaling (GO:0035330)2.24292563
161embryonic retina morphogenesis in camera-type eye (GO:0060059)2.23845500
162heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.22241014
163non-canonical Wnt signaling pathway (GO:0035567)2.21849445
164fatty acid transmembrane transport (GO:1902001)2.21195586
165cell adhesion mediated by integrin (GO:0033627)2.20569929
166negative regulation of lipid transport (GO:0032369)2.18844001
167negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.18506712
168lung-associated mesenchyme development (GO:0060484)2.18494728
169protein hydroxylation (GO:0018126)2.18151066
170regulation of catenin import into nucleus (GO:0035412)2.18087025
171renal system development (GO:0072001)2.17970213
172tricarboxylic acid metabolic process (GO:0072350)2.17019980
173cellular response to vitamin (GO:0071295)2.16115237
174protein localization to endosome (GO:0036010)2.15680070
175positive regulation of lipid catabolic process (GO:0050996)2.15251635
176dicarboxylic acid biosynthetic process (GO:0043650)2.14429228
177sulfur amino acid catabolic process (GO:0000098)2.14336100
178epithelial cell-cell adhesion (GO:0090136)2.13777221
179collecting duct development (GO:0072044)2.12831214
180adherens junction assembly (GO:0034333)2.12459781
181mesenchymal-epithelial cell signaling (GO:0060638)2.12221444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.90539734
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.20832370
3EZH2_22144423_ChIP-Seq_EOC_Human4.14936067
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.08068659
5CLOCK_20551151_ChIP-Seq_293T_Human2.80432853
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58637925
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43926548
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.40017301
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.39606822
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25126325
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.03750274
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01394757
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01107935
14ZNF263_19887448_ChIP-Seq_K562_Human1.99676042
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99444435
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91967029
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85785122
18* LXR_22158963_ChIP-Seq_LIVER_Mouse1.85320717
19RXR_22158963_ChIP-Seq_LIVER_Mouse1.84591706
20* ESR2_21235772_ChIP-Seq_MCF-7_Human1.83126958
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82523297
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.81662140
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81281139
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.80869695
25WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.79040256
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77966407
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76609109
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.72013979
29* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.68862243
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.68502508
31RING1B_27294783_Chip-Seq_ESCs_Mouse1.67684626
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65916647
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65174824
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.62810516
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56906152
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.56249460
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.55557909
38AR_21572438_ChIP-Seq_LNCaP_Human1.53975540
39* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52740416
40SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52197958
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49005817
42KDM2B_26808549_Chip-Seq_K562_Human1.48927275
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48340056
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47547729
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46762947
46OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.45732833
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44243073
48* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.42941820
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42490888
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.40546724
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40388783
52* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39972228
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39607352
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.39454561
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38934322
56* EP300_21415370_ChIP-Seq_HL-1_Mouse1.37889334
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37388769
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35111276
59* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34272977
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34222478
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33496108
62* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32172334
63* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32172334
64RACK7_27058665_Chip-Seq_MCF-7_Human1.30065771
65* TBX20_22080862_ChIP-Seq_HEART_Mouse1.29509482
66* TBX20_22328084_ChIP-Seq_HEART_Mouse1.29509482
67DROSHA_22980978_ChIP-Seq_HELA_Human1.28959583
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28442056
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27149612
70REST_21632747_ChIP-Seq_MESCs_Mouse1.26204468
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26133149
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25525657
73* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24210571
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.23829973
75GBX2_23144817_ChIP-Seq_PC3_Human1.23729305
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23694981
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23694981
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23694981
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23573098
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22366637
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22034490
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21670369
83* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.21593368
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21503172
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.21501027
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.21385850
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19902469
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.19451626
89CJUN_26792858_Chip-Seq_BT549_Human1.18364556
90* ISL1_27105846_Chip-Seq_CPCs_Mouse1.17714707
91KDM2B_26808549_Chip-Seq_DND41_Human1.17271305
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.16635699
93* KDM2B_26808549_Chip-Seq_JURKAT_Human1.16342299
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15143971
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15039053
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15010758
97EED_16625203_ChIP-ChIP_MESCs_Mouse1.14716351
98* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12882767
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12820038
100RXR_22108803_ChIP-Seq_LS180_Human1.12216716
101* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12103086
102TP53_16413492_ChIP-PET_HCT116_Human1.10801404
103PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10094813
104* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09414058
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.09096297
106* FOXA2_19822575_ChIP-Seq_HepG2_Human1.08845307
107* SMAD3_21741376_ChIP-Seq_HESCs_Human1.07638054
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06570445
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05935467
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05745334
111JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05491802
112* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.05213061
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05101223
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04535637
115AR_19668381_ChIP-Seq_PC3_Human1.04350011
116* ATF3_27146783_Chip-Seq_COLON_Human1.04253268
117TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04141800
118POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03752167
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03712890
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03674249
121* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03316594
122NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03260493
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02613931
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02613931
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02349933
126AHR_22903824_ChIP-Seq_MCF-7_Human1.01854466
127LXR_22292898_ChIP-Seq_THP-1_Human1.01613819
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01140135
129RNF2_27304074_Chip-Seq_ESCs_Mouse0.99394378
130CTCF_27219007_Chip-Seq_Bcells_Human0.99139161
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.98734309
132UBF1/2_26484160_Chip-Seq_HMECs_Human0.98651408
133ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98486529
134KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98274550
135NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97870736
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97459797
137* KLF5_25053715_ChIP-Seq_YYC3_Human0.97068030
138TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96465401
139FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96375026
140SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95958295
141SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95958295
142CDX2_20551321_ChIP-Seq_CACO-2_Human0.95595877
143SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95370634
144CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95230560
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.95023070
146* CREB1_26743006_Chip-Seq_LNCaP_Human0.94674258
147LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94128004
148* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92775517
149TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92131477
150NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91885230
151* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91312548
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90347001
153TP53_23651856_ChIP-Seq_MEFs_Mouse0.89906622

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.24510198
2MP0008438_abnormal_cutaneous_collagen3.96274957
3MP0004859_abnormal_synaptic_plasticity3.16547967
4MP0003136_yellow_coat_color2.88239782
5MP0005275_abnormal_skin_tensile2.86722877
6MP0005623_abnormal_meninges_morphology2.70211749
7MP0009384_cardiac_valve_regurgitation2.66176542
8MP0000566_synostosis2.63147472
9MP0010234_abnormal_vibrissa_follicle2.56877746
10MP0002653_abnormal_ependyma_morphology2.56372989
11MP0005670_abnormal_white_adipose2.53095979
12MP0004272_abnormal_basement_membrane2.51979516
13MP0004130_abnormal_muscle_cell2.49778662
14MP0001984_abnormal_olfaction2.44829855
15MP0004270_analgesia2.41929842
16MP0000778_abnormal_nervous_system2.35610154
17MP0004185_abnormal_adipocyte_glucose2.27096064
18MP0005423_abnormal_somatic_nervous2.22389707
19MP0002254_reproductive_system_inflammat2.20132933
20MP0005666_abnormal_adipose_tissue2.18897826
21MP0003300_gastrointestinal_ulcer2.14229203
22MP0004858_abnormal_nervous_system2.10344645
23MP0001502_abnormal_circadian_rhythm2.05309357
24MP0003045_fibrosis1.89671335
25MP0003635_abnormal_synaptic_transmissio1.87474365
26MP0000751_myopathy1.87213095
27MP0009780_abnormal_chondrocyte_physiolo1.83994814
28MP0003634_abnormal_glial_cell1.74905098
29MP0005076_abnormal_cell_differentiation1.74421263
30MP0000733_abnormal_muscle_development1.73862815
31MP0001486_abnormal_startle_reflex1.72179198
32MP0002796_impaired_skin_barrier1.71788019
33MP0005377_hearing/vestibular/ear_phenot1.68003475
34MP0003878_abnormal_ear_physiology1.68003475
35MP0005375_adipose_tissue_phenotype1.67699367
36* MP0002060_abnormal_skin_morphology1.67007492
37MP0002734_abnormal_mechanical_nocicepti1.60541182
38MP0001849_ear_inflammation1.60120966
39MP0000537_abnormal_urethra_morphology1.58557530
40MP0002063_abnormal_learning/memory/cond1.58393130
41MP0004233_abnormal_muscle_weight1.54970313
42MP0002089_abnormal_postnatal_growth/wei1.54192728
43MP0010352_gastrointestinal_tract_polyps1.53962851
44MP0003880_abnormal_central_pattern1.53242103
45MP0002139_abnormal_hepatobiliary_system1.49824974
46MP0010030_abnormal_orbit_morphology1.48205058
47MP0000955_abnormal_spinal_cord1.47579194
48MP0002877_abnormal_melanocyte_morpholog1.47432338
49MP0005503_abnormal_tendon_morphology1.46969463
50MP0003279_aneurysm1.45901207
51MP0000750_abnormal_muscle_regeneration1.44815796
52MP0000003_abnormal_adipose_tissue1.43859286
53MP0010678_abnormal_skin_adnexa1.43057495
54MP0009379_abnormal_foot_pigmentation1.40974894
55MP0002064_seizures1.38668034
56MP0001299_abnormal_eye_distance/1.38267739
57MP0002108_abnormal_muscle_morphology1.37744486
58MP0004087_abnormal_muscle_fiber1.37002427
59MP0002249_abnormal_larynx_morphology1.35043113
60MP0000579_abnormal_nail_morphology1.32518560
61MP0000383_abnormal_hair_follicle1.31044958
62MP0005167_abnormal_blood-brain_barrier1.28491331
63MP0000428_abnormal_craniofacial_morphol1.25922563
64MP0003566_abnormal_cell_adhesion1.25639818
65MP0008569_lethality_at_weaning1.25268273
66MP0002971_abnormal_brown_adipose1.24876517
67MP0002152_abnormal_brain_morphology1.24463266
68MP0003861_abnormal_nervous_system1.23582665
69MP0000467_abnormal_esophagus_morphology1.23471935
70MP0003938_abnormal_ear_development1.22784077
71MP0001485_abnormal_pinna_reflex1.21889247
72MP0009053_abnormal_anal_canal1.21318230
73MP0005508_abnormal_skeleton_morphology1.21014602
74MP0002736_abnormal_nociception_after1.20199729
75MP0001346_abnormal_lacrimal_gland1.20066912
76MP0003283_abnormal_digestive_organ1.19342641
77MP0003115_abnormal_respiratory_system1.19332764
78MP0000920_abnormal_myelination1.18989109
79MP0003091_abnormal_cell_migration1.18648292
80MP0002896_abnormal_bone_mineralization1.17095185
81MP0002572_abnormal_emotion/affect_behav1.16993580
82MP0000026_abnormal_inner_ear1.16774006
83MP0002168_other_aberrant_phenotype1.14897565
84MP0010329_abnormal_lipoprotein_level1.14237969
85MP0002735_abnormal_chemical_nociception1.13609370
86MP0008961_abnormal_basal_metabolism1.12874613
87MP0006138_congestive_heart_failure1.11919881
88MP0002272_abnormal_nervous_system1.11829121
89MP0001958_emphysema1.11415314
90MP0005257_abnormal_intraocular_pressure1.10916363
91MP0003942_abnormal_urinary_system1.09632831
92MP0004133_heterotaxia1.07310783
93MP0003252_abnormal_bile_duct1.07309721
94MP0000762_abnormal_tongue_morphology1.06727063
95MP0009672_abnormal_birth_weight1.06240303
96MP0000534_abnormal_ureter_morphology1.06162469
97MP0000013_abnormal_adipose_tissue1.06017817
98MP0002882_abnormal_neuron_morphology1.05892275
99MP0000759_abnormal_skeletal_muscle1.05373622
100MP0000647_abnormal_sebaceous_gland1.04245569
101MP0000049_abnormal_middle_ear1.04063379
102MP0009745_abnormal_behavioral_response1.03749247
103MP0002116_abnormal_craniofacial_bone1.03116106
104MP0002557_abnormal_social/conspecific_i1.01297667
105MP0003119_abnormal_digestive_system1.00025838
106MP0005646_abnormal_pituitary_gland0.98831732
107* MP0003453_abnormal_keratinocyte_physiol0.98773289
108MP0002233_abnormal_nose_morphology0.97971809
109MP0005360_urolithiasis0.97494975
110MP0000462_abnormal_digestive_system0.97355196
111MP0009250_abnormal_appendicular_skeleto0.96813296
112MP0004885_abnormal_endolymph0.96475630
113MP0003690_abnormal_glial_cell0.93713140
114MP0002909_abnormal_adrenal_gland0.93424582
115MP0005187_abnormal_penis_morphology0.93113854
116MP0010630_abnormal_cardiac_muscle0.92607765
117MP0003937_abnormal_limbs/digits/tail_de0.92315268
118MP0003633_abnormal_nervous_system0.92240393
119MP0002269_muscular_atrophy0.91510149
120MP0001293_anophthalmia0.90802159
121MP0002092_abnormal_eye_morphology0.90317953
122MP0003329_amyloid_beta_deposits0.90230383
123MP0002932_abnormal_joint_morphology0.90174646
124MP0003632_abnormal_nervous_system0.89808851
125MP0001963_abnormal_hearing_physiology0.89797341
126MP0001970_abnormal_pain_threshold0.89735179
127MP0009115_abnormal_fat_cell0.88363552
128MP0005365_abnormal_bile_salt0.88213403
129MP0000749_muscle_degeneration0.85506417
130MP0005620_abnormal_muscle_contractility0.84579174
131MP0003755_abnormal_palate_morphology0.84219894
132MP0000427_abnormal_hair_cycle0.84116867
133MP0005501_abnormal_skin_physiology0.83722170
134MP0002837_dystrophic_cardiac_calcinosis0.83608504
135MP0004811_abnormal_neuron_physiology0.82825244
136MP0005248_abnormal_Harderian_gland0.82623452
137MP0005023_abnormal_wound_healing0.81981035
138* MP0000432_abnormal_head_morphology0.81868863
139MP0003941_abnormal_skin_development0.81723968
140MP0005394_taste/olfaction_phenotype0.80438156
141MP0005499_abnormal_olfactory_system0.80438156
142MP0001968_abnormal_touch/_nociception0.80311482
143MP0002067_abnormal_sensory_capabilities0.80274015
144MP0002066_abnormal_motor_capabilities/c0.79933066
145MP0009703_decreased_birth_body0.79342637
146MP0004084_abnormal_cardiac_muscle0.79336710
147MP0005369_muscle_phenotype0.78840866
148* MP0010771_integument_phenotype0.78293594
149MP0001177_atelectasis0.77910222
150MP0000631_abnormal_neuroendocrine_gland0.77846466
151MP0000747_muscle_weakness0.76639521
152MP0002234_abnormal_pharynx_morphology0.76518771
153MP0003122_maternal_imprinting0.76109450
154MP0005330_cardiomyopathy0.76088505
155MP0003631_nervous_system_phenotype0.75777045
156MP0001544_abnormal_cardiovascular_syste0.75652089
157MP0005385_cardiovascular_system_phenoty0.75652089
158MP0002106_abnormal_muscle_physiology0.75484013
159MP0000377_abnormal_hair_follicle0.74225104
160MP0001340_abnormal_eyelid_morphology0.73870233
161MP0002118_abnormal_lipid_homeostasis0.73323365
162MP0002972_abnormal_cardiac_muscle0.72384263
163MP0002697_abnormal_eye_size0.71891491
164MP0003385_abnormal_body_wall0.71627127
165MP0008775_abnormal_heart_ventricle0.71444822
166MP0004197_abnormal_fetal_growth/weight/0.70939507

Predicted human phenotypes

RankGene SetZ-score
1Ankle contracture (HP:0006466)4.31002974
2Broad metatarsal (HP:0001783)3.91071916
3Shallow orbits (HP:0000586)3.78928465
4Protrusio acetabuli (HP:0003179)3.76126515
5Type 1 muscle fiber predominance (HP:0003803)3.71353927
6Premature rupture of membranes (HP:0001788)3.64538013
7Obstructive sleep apnea (HP:0002870)3.57913965
8Partial duplication of thumb phalanx (HP:0009944)3.52704008
9Atrophic scars (HP:0001075)3.48788672
10Cerebral aneurysm (HP:0004944)3.26426126
11Increased connective tissue (HP:0009025)3.24921220
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.21733692
13Follicular hyperkeratosis (HP:0007502)3.05604214
14Increased variability in muscle fiber diameter (HP:0003557)3.02854087
15Partial duplication of the phalanx of hand (HP:0009999)3.02149329
16Aplasia of the phalanges of the hand (HP:0009802)3.00679355
17Aplasia involving bones of the extremities (HP:0009825)3.00679355
18Aplasia involving bones of the upper limbs (HP:0009823)3.00679355
19Turricephaly (HP:0000262)2.95643717
20Mildly elevated creatine phosphokinase (HP:0008180)2.95486665
21Abnormal ciliary motility (HP:0012262)2.93921948
22Difficulty running (HP:0009046)2.93116638
23Abnormal respiratory epithelium morphology (HP:0012253)2.91105405
24Abnormal respiratory motile cilium morphology (HP:0005938)2.91105405
25Abnormal respiratory motile cilium physiology (HP:0012261)2.87723093
26Fragile skin (HP:0001030)2.87526950
27Split foot (HP:0001839)2.81589599
28Rhinitis (HP:0012384)2.78586788
29Spinal rigidity (HP:0003306)2.76216703
30Neurofibrillary tangles (HP:0002185)2.63697779
31Abnormality of skeletal muscle fiber size (HP:0012084)2.58057914
32Hypoalphalipoproteinemia (HP:0003233)2.57726144
33Milia (HP:0001056)2.57231917
34Exercise-induced muscle cramps (HP:0003710)2.53486848
35Right ventricular cardiomyopathy (HP:0011663)2.52179142
36Coronal craniosynostosis (HP:0004440)2.51761836
37Absent/shortened dynein arms (HP:0200106)2.48956233
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.48956233
39Septo-optic dysplasia (HP:0100842)2.48857697
40Abnormality of the diencephalon (HP:0010662)2.45655744
41Slender build (HP:0001533)2.41780858
42Enlarged penis (HP:0000040)2.40625409
43Abnormality of the 4th metacarpal (HP:0010012)2.38008945
44Bladder diverticulum (HP:0000015)2.37234278
45Exercise-induced myalgia (HP:0003738)2.36547375
46Aortic dissection (HP:0002647)2.34490264
47Megalencephaly (HP:0001355)2.32495777
48Bronchomalacia (HP:0002780)2.29164408
49Mitral valve prolapse (HP:0001634)2.27697048
50Myoglobinuria (HP:0002913)2.27019826
51Acanthosis nigricans (HP:0000956)2.26609915
52Synostosis involving the elbow (HP:0003938)2.26204145
53Humeroradial synostosis (HP:0003041)2.26204145
54Choanal stenosis (HP:0000452)2.26177061
55Deviation of the hallux (HP:0010051)2.25439282
56Hyporeflexia of lower limbs (HP:0002600)2.25218742
57Chronic bronchitis (HP:0004469)2.24179258
58Vertebral arch anomaly (HP:0008438)2.22555268
59Cutaneous syndactyly (HP:0012725)2.22011662
60Muscle fiber splitting (HP:0003555)2.21776439
61Cutaneous finger syndactyly (HP:0010554)2.19543458
62Alopecia of scalp (HP:0002293)2.18733571
63Tarsal synostosis (HP:0008368)2.18720873
64Sleep apnea (HP:0010535)2.17932353
65Myokymia (HP:0002411)2.17805104
66Aneurysm (HP:0002617)2.16749418
67Short 4th metacarpal (HP:0010044)2.15448779
68Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15448779
69Hepatoblastoma (HP:0002884)2.15119772
70Peritonitis (HP:0002586)2.14374419
71Overriding aorta (HP:0002623)2.12341409
72Myocardial infarction (HP:0001658)2.10274453
73Deep venous thrombosis (HP:0002625)2.09634677
74Neonatal short-limb short stature (HP:0008921)2.09143969
75Neoplasm of the heart (HP:0100544)2.09131840
76Hallux valgus (HP:0001822)2.08180318
77Rectal prolapse (HP:0002035)2.07772306
78Achilles tendon contracture (HP:0001771)2.03712568
79Dilatation of the ascending aorta (HP:0005111)2.02049341
80Buphthalmos (HP:0000557)2.01978839
81Back pain (HP:0003418)2.01726471
82Abnormality of the Achilles tendon (HP:0005109)1.98136123
83Xanthomatosis (HP:0000991)1.97021275
84Synostosis involving bones of the feet (HP:0009140)1.94811103
85Synostosis involving bones of the lower limbs (HP:0009138)1.94811103
86Limb-girdle muscle weakness (HP:0003325)1.94542809
87Cerebral inclusion bodies (HP:0100314)1.93385563
88Urethral obstruction (HP:0000796)1.92060470
89Short hallux (HP:0010109)1.91259548
90Genu recurvatum (HP:0002816)1.90360942
91Aortic aneurysm (HP:0004942)1.89863182
92Action tremor (HP:0002345)1.88151956
93Alacrima (HP:0000522)1.87811172
94Peripheral hypomyelination (HP:0007182)1.85508862
95Missing ribs (HP:0000921)1.85114249
96Vertebral clefting (HP:0008428)1.84896301
97Bell-shaped thorax (HP:0001591)1.81871850
98Round ear (HP:0100830)1.81393580
99Macroorchidism (HP:0000053)1.80426592
100Scapular winging (HP:0003691)1.80007131
101Anomalous pulmonary venous return (HP:0010772)1.78925428
102Dysmetric saccades (HP:0000641)1.78844075
103Renovascular hypertension (HP:0100817)1.78619890
104Synostosis of carpal bones (HP:0005048)1.78582203
105Epidermoid cyst (HP:0200040)1.78291909
106Pseudobulbar signs (HP:0002200)1.78205115
107Tracheomalacia (HP:0002779)1.77666284
108Thin ribs (HP:0000883)1.76520420
109Abnormality of the ischium (HP:0003174)1.76196014
110Subacute progressive viral hepatitis (HP:0006572)1.75935711
111Distal upper limb amyotrophy (HP:0007149)1.75845222
112Upper limb amyotrophy (HP:0009129)1.75845222
113Difficulty climbing stairs (HP:0003551)1.75548292
114Hyperextensible skin (HP:0000974)1.75383944
115Insomnia (HP:0100785)1.72874068
116Bowel diverticulosis (HP:0005222)1.72803761
117Skin nodule (HP:0200036)1.72405219
118Hemiplegia (HP:0002301)1.72045657
119Blue sclerae (HP:0000592)1.71879119
120Hyperlipoproteinemia (HP:0010980)1.71137897
121Omphalocele (HP:0001539)1.70724073
122Lymphangioma (HP:0100764)1.70338801
123Hyperacusis (HP:0010780)1.69613316
124Venous abnormality (HP:0002624)1.68490286
125Soft skin (HP:0000977)1.68176630
126Ankyloglossia (HP:0010296)1.68041554
127Elfin facies (HP:0004428)1.67718649
128Anophthalmia (HP:0000528)1.67641518
129Aplasia/Hypoplasia of the hallux (HP:0008362)1.66977498
130Focal motor seizures (HP:0011153)1.66852410
131Broad thumb (HP:0011304)1.66477402
132Bifid scrotum (HP:0000048)1.66255101
133Overgrowth (HP:0001548)1.66229719
134Advanced eruption of teeth (HP:0006288)1.66221179
135Bowel incontinence (HP:0002607)1.65016969
136Muscle stiffness (HP:0003552)1.64927041
137Wide anterior fontanel (HP:0000260)1.64670684
138Abnormality of the salivary glands (HP:0010286)1.64515812
139Atelectasis (HP:0100750)1.63722739
140Hypercortisolism (HP:0001578)1.63030641
141Fibular hypoplasia (HP:0003038)1.62383758
142Maternal diabetes (HP:0009800)1.62054029
143Preaxial foot polydactyly (HP:0001841)1.61964209
144Bronchiectasis (HP:0002110)1.61638117
145Laryngomalacia (HP:0001601)1.61618312
146Hypoventilation (HP:0002791)1.61247313
147Ankle clonus (HP:0011448)1.60276450
148Vitreoretinal degeneration (HP:0000655)1.59910072
149Duplication of thumb phalanx (HP:0009942)1.59390039
150Trigonocephaly (HP:0000243)1.59020118
151Mixed hearing impairment (HP:0000410)1.58754248
152Ketoacidosis (HP:0001993)1.58611921
153Hyperglycemia (HP:0003074)1.58219525
154Hypolipoproteinemia (HP:0010981)1.58009984
155Morphological abnormality of the inner ear (HP:0011390)1.57135335
156Abnormality of the middle phalanges of the toes (HP:0010183)1.57118264
157Arterial tortuosity (HP:0005116)1.56870873
158Arnold-Chiari malformation (HP:0002308)1.56513323
159Dysdiadochokinesis (HP:0002075)1.56419658
160Abnormality of permanent molar morphology (HP:0011071)1.56415932
161Abnormality of the dental root (HP:0006486)1.56415932
162Taurodontia (HP:0000679)1.56415932
163Bundle branch block (HP:0011710)1.55962234
164Oligodactyly (hands) (HP:0001180)1.55936229
165Ulnar bowing (HP:0003031)1.55810366
166Renal duplication (HP:0000075)1.54620256
167Increased circulating renin level (HP:0000848)1.54341738
168Subaortic stenosis (HP:0001682)1.53552050
169Abnormality of the left ventricular outflow tract (HP:0011103)1.53552050
170Hyperkalemia (HP:0002153)1.53392870
171Mitral regurgitation (HP:0001653)1.52577874
172Supernumerary ribs (HP:0005815)1.52049679
173Absent toe (HP:0010760)1.51745715
174Abnormality of the pulmonary veins (HP:0011718)1.51474991
175Thickened helices (HP:0000391)1.51052947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.83291241
2SIK13.61935953
3MARK13.49907026
4PKN22.95665631
5CASK2.86064464
6NTRK32.76920949
7MAPK152.67053985
8LATS12.61913893
9LMTK22.60724567
10RIPK12.60273388
11PDGFRA2.53689905
12TTN2.49638014
13EEF2K2.40882998
14EPHA42.12794509
15FGFR41.95707186
16PTK61.91254055
17TYRO31.87359724
18BMX1.68939596
19DDR21.67438848
20ERN11.67242606
21FGFR21.61524309
22EPHB21.57443025
23NEK61.53351859
24SMG11.51045788
25FER1.50948292
26UHMK11.50790756
27PHKG11.49369596
28PHKG21.49369596
29FGFR11.48933683
30CAMK1D1.48632741
31SGK4941.43760101
32SGK2231.43760101
33LATS21.42332437
34ICK1.41583738
35NTRK21.40206817
36PDGFRB1.36044448
37PNCK1.35212160
38PAK61.34744592
39EPHB11.34655525
40PRKD31.32889866
41MAP3K71.28560270
42FGFR31.27636595
43SGK21.27162474
44PAK31.25077322
45PTK21.24274690
46DYRK1B1.21957467
47TNIK1.21709649
48CAMK1G1.19504277
49PKN11.19321070
50RET1.16639886
51EPHA31.15158201
52ERBB41.14432302
53DMPK1.12214723
54CAMK2G1.12196647
55CAMK2B1.07610689
56PAK21.06681462
57CDK61.02422547
58MTOR1.01052531
59MOS0.97906820
60MAP3K100.95814053
61LRRK20.92297816
62PDK30.91430657
63PDK40.91430657
64PRKCH0.89743504
65ERBB20.88591086
66MAPK100.86709652
67ROCK20.86445388
68TAOK10.86285617
69KSR20.84934015
70NLK0.83873158
71ROCK10.82921603
72EPHA20.81155710
73NTRK10.80951287
74CAMK2D0.80721884
75MAP2K10.79158226
76DYRK20.78770087
77CDK50.76022545
78STK380.75997500
79FRK0.73998309
80PIK3CA0.73600226
81MET0.72413714
82DYRK1A0.72269090
83SGK10.70700997
84NEK10.70634907
85CHUK0.68702020
86CDK120.66186341
87BCKDK0.66162618
88CDK90.65521637
89TNK20.65347887
90MAP3K20.65114029
91MKNK20.64029232
92PRKD10.63661921
93MST1R0.63270259
94STK390.61947633
95KSR10.61813231
96ILK0.61311866
97CAMK10.61082263
98ALK0.59553643
99PRKAA20.57987099
100PRKAA10.57561504
101NEK90.57048544
102RPS6KA20.55776773
103CAMK2A0.55125720
104MAP3K30.55111031
105OBSCN0.54793503
106MAP3K40.54278309
107JAK10.53631561
108PRKDC0.52078410
109ARAF0.51825445
110SGK30.51639742
111CAMKK10.51600612
112MAPK110.51482197
113STK30.48320092
114WNK10.47728170
115GSK3A0.47522400
116RPS6KB10.46739452
117MINK10.46066076
118TRPM70.45214822
119TTK0.44634135
120JAK20.44571804
121INSR0.42549522
122GSK3B0.41814018
123MAPK120.41545994
124INSRR0.41133445
125MARK20.40541899
126BRD40.40210327
127SRC0.39107079
128CAMK40.38381297
129CDC42BPA0.37874685
130TSSK60.37383825
131MAP3K90.36968201
132HIPK20.36822814
133IGF1R0.35434492
134PAK40.35157888
135MAP3K10.35068376
136STK240.34882831
137MAPK70.34239983
138MAP3K130.33793661
139STK38L0.32108912
140MAP2K40.31719365
141RPS6KA10.29160727
142AKT20.28794657
143RPS6KA30.27563329

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.76599689
2Fatty acid biosynthesis_Homo sapiens_hsa000612.55162295
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.22821589
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.21074823
5Fatty acid metabolism_Homo sapiens_hsa012122.16915221
6Fatty acid degradation_Homo sapiens_hsa000712.10081519
7PPAR signaling pathway_Homo sapiens_hsa033202.03341477
8ECM-receptor interaction_Homo sapiens_hsa045121.72087919
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67257238
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64185999
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61628187
12Propanoate metabolism_Homo sapiens_hsa006401.61614722
13Insulin secretion_Homo sapiens_hsa049111.56091743
14Bile secretion_Homo sapiens_hsa049761.54806366
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54298212
16Histidine metabolism_Homo sapiens_hsa003401.54004902
17Circadian entrainment_Homo sapiens_hsa047131.51707416
18Glutamatergic synapse_Homo sapiens_hsa047241.47781207
19Bladder cancer_Homo sapiens_hsa052191.44545076
20Arginine biosynthesis_Homo sapiens_hsa002201.43613551
21Long-term potentiation_Homo sapiens_hsa047201.38880930
22Basal cell carcinoma_Homo sapiens_hsa052171.38645368
23Proteoglycans in cancer_Homo sapiens_hsa052051.35718153
24Prion diseases_Homo sapiens_hsa050201.31319706
25Focal adhesion_Homo sapiens_hsa045101.31221723
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30184348
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27715818
28cAMP signaling pathway_Homo sapiens_hsa040241.27342889
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21920994
30Amphetamine addiction_Homo sapiens_hsa050311.21533250
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.20392806
32Dilated cardiomyopathy_Homo sapiens_hsa054141.20166454
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17345788
34GABAergic synapse_Homo sapiens_hsa047271.16904993
35Insulin resistance_Homo sapiens_hsa049311.15309627
36Small cell lung cancer_Homo sapiens_hsa052221.14923361
37Butanoate metabolism_Homo sapiens_hsa006501.14905258
38Nicotine addiction_Homo sapiens_hsa050331.11627811
39Lysine degradation_Homo sapiens_hsa003101.11621084
40Cocaine addiction_Homo sapiens_hsa050301.11127642
41Adherens junction_Homo sapiens_hsa045201.10129753
42AMPK signaling pathway_Homo sapiens_hsa041521.08087795
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.06542282
44Hippo signaling pathway_Homo sapiens_hsa043901.05730684
45Circadian rhythm_Homo sapiens_hsa047101.03877231
46ErbB signaling pathway_Homo sapiens_hsa040121.03625072
47Oxytocin signaling pathway_Homo sapiens_hsa049211.03081638
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02629002
49Choline metabolism in cancer_Homo sapiens_hsa052311.01317646
50Chronic myeloid leukemia_Homo sapiens_hsa052201.00615841
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.98510921
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.98075858
53Protein digestion and absorption_Homo sapiens_hsa049740.97619916
54Dorso-ventral axis formation_Homo sapiens_hsa043200.97068839
55Carbon metabolism_Homo sapiens_hsa012000.96248225
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95815760
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95388145
58Dopaminergic synapse_Homo sapiens_hsa047280.95379596
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95019454
60Glioma_Homo sapiens_hsa052140.93646522
61Colorectal cancer_Homo sapiens_hsa052100.93619503
62Endometrial cancer_Homo sapiens_hsa052130.92535028
63Cholinergic synapse_Homo sapiens_hsa047250.91904021
64Arginine and proline metabolism_Homo sapiens_hsa003300.91180646
65Amoebiasis_Homo sapiens_hsa051460.90363610
66Hedgehog signaling pathway_Homo sapiens_hsa043400.90255243
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90121990
68Long-term depression_Homo sapiens_hsa047300.89412579
69Gastric acid secretion_Homo sapiens_hsa049710.88680925
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87435231
71Fat digestion and absorption_Homo sapiens_hsa049750.87093377
72Rap1 signaling pathway_Homo sapiens_hsa040150.86777392
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86761434
74Insulin signaling pathway_Homo sapiens_hsa049100.86482238
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84846761
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84502769
77MicroRNAs in cancer_Homo sapiens_hsa052060.83616297
78Tight junction_Homo sapiens_hsa045300.83600382
79Morphine addiction_Homo sapiens_hsa050320.81989786
80mTOR signaling pathway_Homo sapiens_hsa041500.81274586
81Biosynthesis of amino acids_Homo sapiens_hsa012300.79623065
82Viral myocarditis_Homo sapiens_hsa054160.79605553
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.76485966
84Glycerolipid metabolism_Homo sapiens_hsa005610.75652234
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.75324366
86Glucagon signaling pathway_Homo sapiens_hsa049220.74520409
87Vitamin B6 metabolism_Homo sapiens_hsa007500.72492898
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72040178
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71030275
90Calcium signaling pathway_Homo sapiens_hsa040200.71011945
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.69415939
92Tryptophan metabolism_Homo sapiens_hsa003800.69082086
93Type II diabetes mellitus_Homo sapiens_hsa049300.69028233
94beta-Alanine metabolism_Homo sapiens_hsa004100.68601329
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68571297
96Estrogen signaling pathway_Homo sapiens_hsa049150.68283558
97Notch signaling pathway_Homo sapiens_hsa043300.68190104
98Melanogenesis_Homo sapiens_hsa049160.66947356
99Starch and sucrose metabolism_Homo sapiens_hsa005000.66726621
100Pancreatic cancer_Homo sapiens_hsa052120.66337299
101Pyruvate metabolism_Homo sapiens_hsa006200.65989345
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65913696
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64683978
104Ras signaling pathway_Homo sapiens_hsa040140.64631632
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64144560
106Cardiac muscle contraction_Homo sapiens_hsa042600.63405495
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63377301
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63269303
109Melanoma_Homo sapiens_hsa052180.60694779
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59171491
111VEGF signaling pathway_Homo sapiens_hsa043700.59063900
112Taste transduction_Homo sapiens_hsa047420.58878345
113Inositol phosphate metabolism_Homo sapiens_hsa005620.57843828
114TGF-beta signaling pathway_Homo sapiens_hsa043500.57618353
115Thyroid hormone synthesis_Homo sapiens_hsa049180.55864026
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55818090
117GnRH signaling pathway_Homo sapiens_hsa049120.55757998
118Renin secretion_Homo sapiens_hsa049240.55518295
119Thyroid cancer_Homo sapiens_hsa052160.55499993
120Salivary secretion_Homo sapiens_hsa049700.54818099
121Prostate cancer_Homo sapiens_hsa052150.54472644
122Non-small cell lung cancer_Homo sapiens_hsa052230.50158148
123Phenylalanine metabolism_Homo sapiens_hsa003600.48836578
124Sulfur metabolism_Homo sapiens_hsa009200.48588376
125Wnt signaling pathway_Homo sapiens_hsa043100.48474458
126Prolactin signaling pathway_Homo sapiens_hsa049170.47424204
127Chemical carcinogenesis_Homo sapiens_hsa052040.46901725
128Complement and coagulation cascades_Homo sapiens_hsa046100.46872152
129Pathways in cancer_Homo sapiens_hsa052000.46454316
130Axon guidance_Homo sapiens_hsa043600.46379582
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46085076
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44710760
133Renal cell carcinoma_Homo sapiens_hsa052110.44573346
134Pancreatic secretion_Homo sapiens_hsa049720.42584790
135Gap junction_Homo sapiens_hsa045400.41567201
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.40709798
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40687408

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