LRIG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)4.84556283
2negative regulation of keratinocyte proliferation (GO:0010839)4.62530990
3regulation of cardioblast differentiation (GO:0051890)4.60012316
4planar cell polarity pathway involved in neural tube closure (GO:0090179)4.42157400
5G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.30936521
6bundle of His cell to Purkinje myocyte communication (GO:0086069)4.26420762
7outer ear morphogenesis (GO:0042473)4.24584217
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.11291782
9bone trabecula formation (GO:0060346)3.99945026
10lateral sprouting from an epithelium (GO:0060601)3.98241831
11hippo signaling (GO:0035329)3.76693027
12collagen fibril organization (GO:0030199)3.76372027
13regulation of transforming growth factor beta2 production (GO:0032909)3.75113044
14establishment of skin barrier (GO:0061436)3.70904134
15polarized epithelial cell differentiation (GO:0030859)3.64157073
16establishment of apical/basal cell polarity (GO:0035089)3.62278516
17chondrocyte proliferation (GO:0035988)3.57961411
18regulation of water loss via skin (GO:0033561)3.56779389
19notochord development (GO:0030903)3.52659417
20embryonic foregut morphogenesis (GO:0048617)3.51678397
21protein heterotrimerization (GO:0070208)3.50756006
22regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.45150235
23midgut development (GO:0007494)3.44241198
24anterior/posterior axis specification, embryo (GO:0008595)3.39968977
25mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.39236853
26genitalia morphogenesis (GO:0035112)3.38639647
27gap junction assembly (GO:0016264)3.29641251
28regulation of posttranscriptional gene silencing (GO:0060147)3.27124470
29regulation of gene silencing by miRNA (GO:0060964)3.27124470
30regulation of gene silencing by RNA (GO:0060966)3.27124470
31regulation of keratinocyte proliferation (GO:0010837)3.27009345
32mesenchymal cell proliferation (GO:0010463)3.25817638
33embryonic skeletal joint morphogenesis (GO:0060272)3.14794608
34craniofacial suture morphogenesis (GO:0097094)3.14330515
35cochlea morphogenesis (GO:0090103)3.13977810
36cell proliferation involved in metanephros development (GO:0072203)3.11007607
37endodermal cell differentiation (GO:0035987)3.09064845
38Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.08577887
39non-canonical Wnt signaling pathway (GO:0035567)3.06188457
40cranial suture morphogenesis (GO:0060363)3.03136831
41embryonic cranial skeleton morphogenesis (GO:0048701)3.02811500
42positive regulation of SMAD protein import into nucleus (GO:0060391)2.99272899
43regulation of establishment of planar polarity (GO:0090175)2.95597925
44regulation of gastrulation (GO:0010470)2.95196405
45hindlimb morphogenesis (GO:0035137)2.94903237
46negative regulation of chondrocyte differentiation (GO:0032331)2.93201721
47keratinocyte proliferation (GO:0043616)2.92206593
48organ formation (GO:0048645)2.91062141
49regulation of SMAD protein import into nucleus (GO:0060390)2.90659667
50establishment or maintenance of monopolar cell polarity (GO:0061339)2.89696068
51establishment of monopolar cell polarity (GO:0061162)2.89696068
52morphogenesis of an epithelial fold (GO:0060571)2.89670662
53anatomical structure regression (GO:0060033)2.88970081
54gastrulation with mouth forming second (GO:0001702)2.88704926
55sequestering of extracellular ligand from receptor (GO:0035581)2.88380749
56neuron projection extension involved in neuron projection guidance (GO:1902284)2.86825072
57axon extension involved in axon guidance (GO:0048846)2.86825072
58artery development (GO:0060840)2.86563584
59prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.86187134
60regulation of hippo signaling (GO:0035330)2.86009809
61regulation of heart morphogenesis (GO:2000826)2.85634070
62negative regulation of embryonic development (GO:0045992)2.85147508
63regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.84870501
64desmosome organization (GO:0002934)2.84590514
65organ induction (GO:0001759)2.83673663
66skin morphogenesis (GO:0043589)2.83495735
67embryonic camera-type eye development (GO:0031076)2.83322092
68smooth muscle tissue development (GO:0048745)2.82324927
69regulation of mesoderm development (GO:2000380)2.82023366
70endocardial cushion development (GO:0003197)2.81455972
71negative regulation of DNA repair (GO:0045738)2.80895543
72glomerular basement membrane development (GO:0032836)2.77712862
73nodal signaling pathway (GO:0038092)2.77333846
74mesenchyme development (GO:0060485)2.76076691
75middle ear morphogenesis (GO:0042474)2.74988054
76atrioventricular valve morphogenesis (GO:0003181)2.74429902
77mesenchymal-epithelial cell signaling (GO:0060638)2.74291831
78hemidesmosome assembly (GO:0031581)2.74129209
79embryonic hindlimb morphogenesis (GO:0035116)2.73986392
80regulation of catenin import into nucleus (GO:0035412)2.73858275
81intestinal epithelial cell development (GO:0060576)2.73684820
82positive regulation of catenin import into nucleus (GO:0035413)2.72833758
83convergent extension (GO:0060026)2.71541376
84cell migration involved in gastrulation (GO:0042074)2.71043424
85cell migration involved in sprouting angiogenesis (GO:0002042)2.70846008
86negative regulation of cell fate specification (GO:0009996)2.70760625
87cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.69960095
88bone morphogenesis (GO:0060349)2.69941165
89lung-associated mesenchyme development (GO:0060484)2.69140396
90positive regulation of mesenchymal cell proliferation (GO:0002053)2.68485936
91proximal/distal pattern formation (GO:0009954)2.67863347
92epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.66240768
93DNA unwinding involved in DNA replication (GO:0006268)2.65932995
94regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.65549740
95multicellular organismal water homeostasis (GO:0050891)2.64188283
96glomerular filtration (GO:0003094)2.62592392
97establishment of planar polarity (GO:0001736)2.62502417
98establishment of tissue polarity (GO:0007164)2.62502417
99regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.61798910
100mesenchymal to epithelial transition (GO:0060231)2.61546229
101regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61399716
102positive regulation of fatty acid beta-oxidation (GO:0032000)2.60158753
103cell surface receptor signaling pathway involved in heart development (GO:0061311)2.59694749
104neural crest cell development (GO:0014032)2.59046233
105chondrocyte development (GO:0002063)2.58840430
106cell migration involved in heart development (GO:0060973)2.58319536
107body morphogenesis (GO:0010171)2.57593020
108renal filtration (GO:0097205)2.57097825
109cell proliferation involved in kidney development (GO:0072111)2.56947886
110lymphangiogenesis (GO:0001946)2.56638415
111head development (GO:0060322)2.56626836
112negative regulation of catenin import into nucleus (GO:0035414)2.56409109
113positive regulation of smoothened signaling pathway (GO:0045880)2.56098415
114negative regulation of cartilage development (GO:0061037)2.55450364
115pre-miRNA processing (GO:0031054)2.55126993
116positive regulation of epithelial to mesenchymal transition (GO:0010718)2.54357267
117negative regulation of hormone biosynthetic process (GO:0032353)2.53227106
118pericardium development (GO:0060039)2.52684623
119heterochromatin organization (GO:0070828)2.52391698
120dorsal/ventral axis specification (GO:0009950)2.52383447
121vascular endothelial growth factor signaling pathway (GO:0038084)2.51651251
122axis elongation (GO:0003401)2.51279951
123COPII vesicle coating (GO:0048208)2.50652079
124branching involved in prostate gland morphogenesis (GO:0060442)2.50200106
125retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49759504
126basement membrane organization (GO:0071711)2.49570443
127negative chemotaxis (GO:0050919)2.49284350
128branching involved in salivary gland morphogenesis (GO:0060445)2.48672592
129outflow tract septum morphogenesis (GO:0003148)2.48429900
130primitive streak formation (GO:0090009)2.48359739
131endoderm development (GO:0007492)2.47991422
132anterior/posterior axis specification (GO:0009948)2.47030778
133collagen metabolic process (GO:0032963)2.46293301
134epithelial cell-cell adhesion (GO:0090136)2.45137819
135substrate adhesion-dependent cell spreading (GO:0034446)2.45063475
136extracellular regulation of signal transduction (GO:1900115)2.44953385
137extracellular negative regulation of signal transduction (GO:1900116)2.44953385
138embryonic retina morphogenesis in camera-type eye (GO:0060059)2.43180401
139multicellular organismal macromolecule metabolic process (GO:0044259)2.39770288
140collagen catabolic process (GO:0030574)2.39478387
141negative regulation of activin receptor signaling pathway (GO:0032926)2.39324836
142regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.38387157
143keratinization (GO:0031424)2.37284103
144dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.36418548
145regulation of transforming growth factor beta1 production (GO:0032908)2.36351464
146negative regulation of axon guidance (GO:1902668)2.35736084
147apical protein localization (GO:0045176)2.34448402
148regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.34088897
149multicellular organismal metabolic process (GO:0044236)2.33482874
150negative regulation of hormone metabolic process (GO:0032351)2.33078452
151multicellular organismal catabolic process (GO:0044243)2.29838650
152regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.29624635
153signal transduction involved in regulation of gene expression (GO:0023019)2.29113955
154cell adhesion mediated by integrin (GO:0033627)2.29084926
155regulation of axon guidance (GO:1902667)2.28325806
156negative regulation of axon extension involved in axon guidance (GO:0048843)2.28240223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.47377000
2E2F7_22180533_ChIP-Seq_HELA_Human3.98877972
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.52964245
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.52644449
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.40528926
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.40528926
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.40528926
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.85949772
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.51165593
10TCF3_18692474_ChIP-Seq_MEFs_Mouse2.42511243
11* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.41701790
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.29990755
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.28513952
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21570238
15AR_21909140_ChIP-Seq_LNCAP_Human2.17338617
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.14440998
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08012955
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07158647
19CLOCK_20551151_ChIP-Seq_293T_Human2.07153624
20EP300_21415370_ChIP-Seq_HL-1_Mouse2.05008604
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03825115
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03801529
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.03176408
24* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99762541
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98744315
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.97285561
27TCF3_18692474_ChIP-Seq_MESCs_Mouse1.96467794
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95452199
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95125884
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.94888016
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.94437413
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.93947846
33* SMAD3_21741376_ChIP-Seq_HESCs_Human1.93633860
34* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.92660052
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.90927580
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.90914579
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78905904
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.78489716
39* SALL1_21062744_ChIP-ChIP_HESCs_Human1.76454554
40* TP53_18474530_ChIP-ChIP_U2OS_Human1.74618537
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73560222
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.71415691
43NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.71415691
44KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.71096467
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70768175
46ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.64891998
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61398511
48* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60755468
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.60553418
50* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.59025440
51* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.58794411
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.58724321
53* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55781527
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54371146
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52876086
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52247785
57* TP53_20018659_ChIP-ChIP_R1E_Mouse1.51619270
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50360951
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48706916
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47654553
61* AHR_22903824_ChIP-Seq_MCF-7_Human1.46972062
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.46027780
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.45942952
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.45246021
65* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45229146
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.44585137
67* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43778322
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41989324
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36658981
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35950884
71FUS_26573619_Chip-Seq_HEK293_Human1.35013554
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34908223
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34433350
74* SMAD4_21741376_ChIP-Seq_HESCs_Human1.33660289
75* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33508741
76* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32953599
77TCF4_18268006_ChIP-ChIP_LS174T_Human1.32628002
78* ARNT_22903824_ChIP-Seq_MCF-7_Human1.32058993
79TP63_23658742_ChIP-Seq_EP156T_Human1.31429184
80* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31222884
81ISL1_27105846_Chip-Seq_CPCs_Mouse1.31139708
82* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30071162
83BCAT_22108803_ChIP-Seq_LS180_Human1.29544458
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28336927
85* SMAD4_21799915_ChIP-Seq_A2780_Human1.27895587
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27634180
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26916659
88* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.26896527
89SOX2_20726797_ChIP-Seq_SW620_Human1.26591180
90POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26001232
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25618701
92* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25057800
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24523911
94ZNF263_19887448_ChIP-Seq_K562_Human1.23494610
95* NANOG_16153702_ChIP-ChIP_HESCs_Human1.23194486
96* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21799247
97SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21770479
98* BRD4_25478319_ChIP-Seq_HGPS_Human1.21468114
99GBX2_23144817_ChIP-Seq_PC3_Human1.21066242
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19926458
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19776036
102* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.19529973
103* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19332998
104* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18799850
105* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18799850
106* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18743688
107TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17887414
108TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17784723
109* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.17406502
110SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17089788
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16248028
112POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16162258
113* GATA4_25053715_ChIP-Seq_YYC3_Human1.16158762
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14832940
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14518603
116TP53_16413492_ChIP-PET_HCT116_Human1.13955006
117* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13933040
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13639253
119STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13096464
120ATF3_27146783_Chip-Seq_COLON_Human1.13091556
121FOXO3_23340844_ChIP-Seq_DLD1_Human1.13054039
122NANOG_18692474_ChIP-Seq_MEFs_Mouse1.12712468
123P300_19829295_ChIP-Seq_ESCs_Human1.11457727
124* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11346413
125NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11026467
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10741403
127* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09668554
128ESR2_21235772_ChIP-Seq_MCF-7_Human1.08988536
129NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08004305
130NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07304482
131UBF1/2_26484160_Chip-Seq_HMECs_Human1.06994349
132NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06879661
133* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06616314
134NANOG_21062744_ChIP-ChIP_HESCs_Human1.05013534
135* RXR_22158963_ChIP-Seq_LIVER_Mouse1.04911478
136PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04796461
137GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04733482
138SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04072805
139FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03737713
140ELK3_25401928_ChIP-Seq_HUVEC_Human1.03387807
141TP53_22127205_ChIP-Seq_IMR90_Human1.03367677
142CDX2_20551321_ChIP-Seq_CACO-2_Human1.03308520
143RACK7_27058665_Chip-Seq_MCF-7_Human1.03169116
144SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02908194
145CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02871113
146MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02319037
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01715522
148LXR_22158963_ChIP-Seq_LIVER_Mouse1.00013395
149SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99925368
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99786416
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99776578
152TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99776141
153OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99682358
154* CJUN_26792858_Chip-Seq_BT549_Human0.98892137
155CDX2_22108803_ChIP-Seq_LS180_Human0.98763379
156EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98666783
157RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98666783
158FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97963446
159EZH2_27304074_Chip-Seq_ESCs_Mouse0.94784306
160* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94248033

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.17946779
2MP0003705_abnormal_hypodermis_morpholog3.69468931
3MP0010030_abnormal_orbit_morphology3.55088849
4MP0009053_abnormal_anal_canal3.38460165
5MP0005275_abnormal_skin_tensile3.27284757
6MP0005503_abnormal_tendon_morphology2.91542677
7MP0003941_abnormal_skin_development2.59105836
8MP0000537_abnormal_urethra_morphology2.46971242
9MP0010368_abnormal_lymphatic_system2.34718001
10MP0003385_abnormal_body_wall2.18239142
11MP0000566_synostosis2.06748746
12MP0003937_abnormal_limbs/digits/tail_de2.04386052
13MP0002249_abnormal_larynx_morphology2.02094548
14MP0009250_abnormal_appendicular_skeleto2.01191112
15MP0004272_abnormal_basement_membrane2.00339299
16MP0002060_abnormal_skin_morphology1.86877275
17MP0005623_abnormal_meninges_morphology1.85648949
18MP0010352_gastrointestinal_tract_polyps1.84826078
19MP0003123_paternal_imprinting1.83100632
20MP0003942_abnormal_urinary_system1.77365624
21MP0009384_cardiac_valve_regurgitation1.72001492
22MP0005508_abnormal_skeleton_morphology1.71469398
23MP0000762_abnormal_tongue_morphology1.68846061
24MP0002932_abnormal_joint_morphology1.68800493
25MP0003755_abnormal_palate_morphology1.62320153
26MP0000049_abnormal_middle_ear1.58883107
27MP0003283_abnormal_digestive_organ1.58580458
28MP0000579_abnormal_nail_morphology1.57918493
29MP0002282_abnormal_trachea_morphology1.54184863
30MP0000467_abnormal_esophagus_morphology1.51146172
31* MP0000428_abnormal_craniofacial_morphol1.48648829
32MP0002111_abnormal_tail_morphology1.47795506
33MP0002796_impaired_skin_barrier1.47377125
34MP0003119_abnormal_digestive_system1.43190893
35MP0000534_abnormal_ureter_morphology1.42654562
36MP0001293_anophthalmia1.42336055
37MP0000462_abnormal_digestive_system1.42057275
38MP0010234_abnormal_vibrissa_follicle1.41806337
39MP0005076_abnormal_cell_differentiation1.41224388
40MP0001879_abnormal_lymphatic_vessel1.39570074
41MP0004264_abnormal_extraembryonic_tissu1.39094640
42MP0005023_abnormal_wound_healing1.36186948
43MP0002233_abnormal_nose_morphology1.36005784
44MP0009780_abnormal_chondrocyte_physiolo1.35794116
45MP0003115_abnormal_respiratory_system1.35419299
46* MP0000432_abnormal_head_morphology1.35413918
47MP0004197_abnormal_fetal_growth/weight/1.34066275
48MP0003935_abnormal_craniofacial_develop1.33583167
49MP0000383_abnormal_hair_follicle1.33036034
50MP0003890_abnormal_embryonic-extraembry1.31778898
51MP0003566_abnormal_cell_adhesion1.31467159
52MP0000733_abnormal_muscle_development1.30545956
53MP0010678_abnormal_skin_adnexa1.26270641
54MP0008004_abnormal_stomach_pH1.26268237
55MP0002084_abnormal_developmental_patter1.24891013
56MP0002938_white_spotting1.24259284
57MP0005248_abnormal_Harderian_gland1.24096096
58MP0001849_ear_inflammation1.23748304
59MP0002098_abnormal_vibrissa_morphology1.23628790
60MP0002092_abnormal_eye_morphology1.23213914
61MP0002697_abnormal_eye_size1.23141972
62MP0001243_abnormal_dermal_layer1.22727426
63MP0000516_abnormal_urinary_system1.20065592
64MP0005367_renal/urinary_system_phenotyp1.20065592
65MP0003122_maternal_imprinting1.19253671
66MP0002085_abnormal_embryonic_tissue1.18806075
67MP0005257_abnormal_intraocular_pressure1.18462289
68MP0001346_abnormal_lacrimal_gland1.16298770
69MP0002254_reproductive_system_inflammat1.15300963
70MP0002116_abnormal_craniofacial_bone1.14893020
71MP0006054_spinal_hemorrhage1.13999667
72MP0001958_emphysema1.12737303
73MP0002108_abnormal_muscle_morphology1.12029844
74MP0003950_abnormal_plasma_membrane1.11931442
75MP0001299_abnormal_eye_distance/1.11724516
76MP0000163_abnormal_cartilage_morphology1.11480222
77MP0005501_abnormal_skin_physiology1.11161772
78MP0002109_abnormal_limb_morphology1.10892667
79MP0005187_abnormal_penis_morphology1.09191639
80MP0000767_abnormal_smooth_muscle1.08947356
81MP0000647_abnormal_sebaceous_gland1.08226932
82MP0004133_heterotaxia1.07560325
83MP0002234_abnormal_pharynx_morphology1.06655973
84MP0003279_aneurysm1.06356000
85MP0003121_genomic_imprinting1.06067295
86MP0002115_abnormal_skeleton_extremities1.04672676
87MP0001340_abnormal_eyelid_morphology1.03757412
88MP0004957_abnormal_blastocyst_morpholog1.01262774
89MP0003453_abnormal_keratinocyte_physiol1.00914436
90MP0002295_abnormal_pulmonary_circulatio1.00654764
91MP0008932_abnormal_embryonic_tissue0.98464211
92MP0001661_extended_life_span0.97264039
93MP0009379_abnormal_foot_pigmentation0.97087848
94MP0002114_abnormal_axial_skeleton0.96408573
95MP0002896_abnormal_bone_mineralization0.95542003
96MP0005360_urolithiasis0.95381473
97MP0001672_abnormal_embryogenesis/_devel0.95226746
98MP0005380_embryogenesis_phenotype0.95226746
99MP0000377_abnormal_hair_follicle0.95199820
100MP0001286_abnormal_eye_development0.94860150
101MP0004185_abnormal_adipocyte_glucose0.94851966
102MP0005394_taste/olfaction_phenotype0.93037490
103MP0005499_abnormal_olfactory_system0.93037490
104MP0005197_abnormal_uvea_morphology0.92430801
105MP0010771_integument_phenotype0.90746831
106MP0003315_abnormal_perineum_morphology0.88976710
107MP0002086_abnormal_extraembryonic_tissu0.88025568
108* MP0003938_abnormal_ear_development0.87828150
109MP0008789_abnormal_olfactory_epithelium0.87179090
110MP0000013_abnormal_adipose_tissue0.86756995
111MP0000350_abnormal_cell_proliferation0.86076021
112MP0001697_abnormal_embryo_size0.86047431
113MP0001216_abnormal_epidermal_layer0.85350171
114MP0000427_abnormal_hair_cycle0.84375583
115MP0002088_abnormal_embryonic_growth/wei0.84096668
116MP0002177_abnormal_outer_ear0.83267991
117MP0004134_abnormal_chest_morphology0.83246337
118MP0002925_abnormal_cardiovascular_devel0.81669134
119MP0003252_abnormal_bile_duct0.71570472
120MP0005409_darkened_coat_color0.68207872
121MP0001614_abnormal_blood_vessel0.66671989

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.88282956
2Premature rupture of membranes (HP:0001788)4.59608798
3Shallow orbits (HP:0000586)4.04724966
4Short 4th metacarpal (HP:0010044)3.80182746
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.80182746
6Ankle contracture (HP:0006466)3.42815057
7Abnormality of the 4th metacarpal (HP:0010012)3.39314032
8Atrophic scars (HP:0001075)3.25616326
9Right ventricular cardiomyopathy (HP:0011663)3.13697282
10Neonatal short-limb short stature (HP:0008921)3.01154743
11Coronal craniosynostosis (HP:0004440)2.80927232
12Double outlet right ventricle (HP:0001719)2.80822162
13Congenital malformation of the right heart (HP:0011723)2.80822162
14Broad metatarsal (HP:0001783)2.70674655
15Soft skin (HP:0000977)2.68954238
16Aortic dissection (HP:0002647)2.68016478
17Mitral valve prolapse (HP:0001634)2.55885671
18Peritonitis (HP:0002586)2.54457697
19Vascular tortuosity (HP:0004948)2.50563668
20Abnormality of the distal phalanx of the thumb (HP:0009617)2.46737151
21Mesomelia (HP:0003027)2.46393600
22Fragile skin (HP:0001030)2.43786974
23Arterial tortuosity (HP:0005116)2.38653867
24Partial duplication of the phalanx of hand (HP:0009999)2.38289683
25Abnormality of dentin (HP:0010299)2.38181442
26Labial hypoplasia (HP:0000066)2.36029235
27Bladder diverticulum (HP:0000015)2.35614028
28Broad thumb (HP:0011304)2.33267224
29Renal duplication (HP:0000075)2.30696852
30Genu recurvatum (HP:0002816)2.28264226
31Wide anterior fontanel (HP:0000260)2.26648151
32Blue sclerae (HP:0000592)2.26520814
33Overgrowth (HP:0001548)2.25360467
34Abnormality of the 2nd finger (HP:0004100)2.24512622
35Deviation of the hallux (HP:0010051)2.23574104
36Alopecia of scalp (HP:0002293)2.21678787
37Cerebral aneurysm (HP:0004944)2.21608852
38Hypoplastic female external genitalia (HP:0012815)2.20797884
39Selective tooth agenesis (HP:0001592)2.17019452
40Ulnar bowing (HP:0003031)2.16703300
41Abnormality of the phalanges of the hallux (HP:0010057)2.14381203
42Abnormality of the parietal bone (HP:0002696)2.13101481
43Broad toe (HP:0001837)2.12884671
44Onycholysis (HP:0001806)2.06035155
45Synostosis of carpal bones (HP:0005048)2.05943074
46Abnormality of abdominal situs (HP:0011620)2.05760207
47Abdominal situs inversus (HP:0003363)2.05760207
48Hallux valgus (HP:0001822)2.05580744
49Broad long bones (HP:0005622)2.04403327
50Bifid tongue (HP:0010297)2.04124380
51Absent frontal sinuses (HP:0002688)2.02921607
52Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.01535000
53Follicular hyperkeratosis (HP:0007502)2.01452199
54Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.99705754
55Turricephaly (HP:0000262)1.98721752
56Short phalanx of the thumb (HP:0009660)1.98474227
57Increased connective tissue (HP:0009025)1.98422067
58Preaxial foot polydactyly (HP:0001841)1.98233302
59Cervical subluxation (HP:0003308)1.97239499
60Natal tooth (HP:0000695)1.97078325
61Wrist flexion contracture (HP:0001239)1.96875837
62Absent eyelashes (HP:0000561)1.95711154
63Osteolytic defects of the phalanges of the hand (HP:0009771)1.94660003
64Osteolytic defects of the hand bones (HP:0009699)1.94660003
65Cutaneous syndactyly (HP:0012725)1.94209927
66Hypoplastic labia majora (HP:0000059)1.93494662
67Dilatation of the ascending aorta (HP:0005111)1.93148847
68Hepatoblastoma (HP:0002884)1.92930371
69Broad phalanges of the hand (HP:0009768)1.91274608
70Aortic aneurysm (HP:0004942)1.91203213
71Abnormal umbilical cord blood vessels (HP:0011403)1.90150036
72Single umbilical artery (HP:0001195)1.90150036
73Abnormality of the fetal cardiovascular system (HP:0010948)1.90150036
74Broad phalanx (HP:0006009)1.88232408
75Short 5th finger (HP:0009237)1.87954163
76Carpal synostosis (HP:0009702)1.87542164
77Advanced eruption of teeth (HP:0006288)1.86586672
78Wormian bones (HP:0002645)1.86225231
79Spinal rigidity (HP:0003306)1.85452907
80Abnormality of the middle phalanges of the toes (HP:0010183)1.84487695
81Popliteal pterygium (HP:0009756)1.84308197
82Short nail (HP:0001799)1.83918199
83Abnormality of molar morphology (HP:0011070)1.83701333
84Abnormality of molar (HP:0011077)1.83701333
85Limited hip movement (HP:0008800)1.83618000
86Supernumerary ribs (HP:0005815)1.83474319
87Abnormality of nail color (HP:0100643)1.83197444
88Broad finger (HP:0001500)1.82991395
89Type 1 muscle fiber predominance (HP:0003803)1.82772441
90Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.82546771
91Short 1st metacarpal (HP:0010034)1.82546771
92Abnormality of the distal phalanges of the toes (HP:0010182)1.81311256
93Abnormal ventriculo-arterial connection (HP:0011563)1.81191793
94Transposition of the great arteries (HP:0001669)1.81191793
95Abnormal connection of the cardiac segments (HP:0011545)1.81191793
96Plantar hyperkeratosis (HP:0007556)1.80743386
97Abnormal pancreas size (HP:0012094)1.80590664
98Pterygium (HP:0001059)1.80436317
99Hyperextensible skin (HP:0000974)1.80264647
100Cardiovascular calcification (HP:0011915)1.79534875
101Short humerus (HP:0005792)1.77272778
102Abnormal ossification of hand bones (HP:0005921)1.75406202
103Abnormality of the labia majora (HP:0012881)1.75169867
104Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.74582577
105Abnormality of permanent molar morphology (HP:0011071)1.73884075
106Abnormality of the dental root (HP:0006486)1.73884075
107Taurodontia (HP:0000679)1.73884075
108Hydroureter (HP:0000072)1.73106030
109Broad hallux (HP:0010055)1.73088711
110Cutaneous finger syndactyly (HP:0010554)1.72975752
111Anal stenosis (HP:0002025)1.72290535
112Elbow flexion contracture (HP:0002987)1.71473654
113Bell-shaped thorax (HP:0001591)1.71324632
114Hypotrichosis (HP:0001006)1.71293656
115Down-sloping shoulders (HP:0200021)1.70908643
116Tibial bowing (HP:0002982)1.70251794
117Abnormality of the nasal septum (HP:0000419)1.70233529
118Colon cancer (HP:0003003)1.69935047
119Camptodactyly of toe (HP:0001836)1.69563409
120Aplasia/hypoplasia of the humerus (HP:0006507)1.69308501
121Abnormality of the peritoneum (HP:0002585)1.69052020
122Abnormality of the dental pulp (HP:0006479)1.68713805
123Partial duplication of thumb phalanx (HP:0009944)1.68545290
124Abnormal delivery (HP:0001787)1.68353710
125Palmar hyperkeratosis (HP:0010765)1.67297725
126Short middle phalanx of the 5th finger (HP:0004220)1.67235601
127Tarsal synostosis (HP:0008368)1.67206911
128Large earlobe (HP:0009748)1.67102836
129Laryngomalacia (HP:0001601)1.66471891
130Morphological abnormality of the middle ear (HP:0008609)1.65750529
131Supernumerary bones of the axial skeleton (HP:0009144)1.65702275
132Infantile muscular hypotonia (HP:0008947)1.65304601
133Esophageal atresia (HP:0002032)1.65080973
134Short middle phalanx of finger (HP:0005819)1.65080195
135Rib fusion (HP:0000902)1.64775996
136Abnormality of the 1st metacarpal (HP:0010009)1.64440281
137Abnormality of the umbilical cord (HP:0010881)1.64246809
138Short hallux (HP:0010109)1.63393369
139Bifid scrotum (HP:0000048)1.62942703
140Abnormality of the acetabulum (HP:0003170)1.62650760
141Biconcave vertebral bodies (HP:0004586)1.62479119
142Milia (HP:0001056)1.62164453
143Abnormality of the ischium (HP:0003174)1.61347531
144Mildly elevated creatine phosphokinase (HP:0008180)1.61061137
145Aplasia involving bones of the extremities (HP:0009825)1.61009774
146Aplasia involving bones of the upper limbs (HP:0009823)1.61009774
147Aplasia of the phalanges of the hand (HP:0009802)1.61009774
148Palmoplantar hyperkeratosis (HP:0000972)1.60804229
149Bowel diverticulosis (HP:0005222)1.60676560
150Fused cervical vertebrae (HP:0002949)1.60293485
151Vitreoretinal degeneration (HP:0000655)1.60199827
152Deviation of the thumb (HP:0009603)1.60183819
153Concave nail (HP:0001598)1.60021591
154Skin pits (HP:0100276)1.58994487
155Hypoplasia of the iris (HP:0007676)1.58377644
156Mitral stenosis (HP:0001718)1.57744643
157Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.57592938
158Hypoplastic scapulae (HP:0000882)1.57573837
159Aplasia/Hypoplasia of the scapulae (HP:0006713)1.57573837
160Abnormality of the labia (HP:0000058)1.56270786
161Missing ribs (HP:0000921)1.56127205
162Fragile nails (HP:0001808)1.55821994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.49831677
2DDR23.52906081
3CDK123.02753186
4LATS22.73168431
5TIE12.68735467
6PDGFRA2.67353261
7EPHB22.56476630
8SIK12.39460564
9BRSK22.22540150
10TTN2.20316545
11MET2.08711641
12MAP3K102.02568279
13MYLK1.92788085
14EPHA21.87259490
15TTK1.84170401
16EEF2K1.75947670
17ICK1.66494688
18FGFR11.62639549
19PTK61.61613699
20CDC71.60635386
21AKT31.59951505
22STK31.58078341
23PKN21.48002656
24FGFR21.47682070
25RPS6KB21.44639279
26BUB11.43944090
27TRIB31.42810467
28STK38L1.41428925
29PAK41.39364010
30RIPK11.39223961
31MTOR1.37250154
32PAK21.37214616
33CAMK1G1.36515465
34BMX1.34814816
35NLK1.34255447
36TLK11.33867928
37ACVR1B1.33627840
38BMPR1B1.31848581
39MKNK11.28771859
40PTK21.25541527
41MST1R1.24599721
42CDK71.24306632
43MAP3K21.24037758
44FER1.23462031
45NEK21.16835549
46NTRK11.14225231
47OXSR11.12715006
48MST41.11488598
49CASK1.10232660
50ERN11.08860935
51ERBB21.08833240
52LMTK21.08270475
53CDK61.07103110
54MAP3K81.05255692
55STK101.04367528
56GRK11.01638012
57ERBB41.00581396
58TGFBR11.00192304
59PASK0.99039957
60STK390.97170818
61EPHA30.94551764
62LRRK20.93275638
63FRK0.89964873
64PDGFRB0.88332003
65RPS6KA40.86183670
66EPHA40.85316429
67AURKB0.84909003
68ERBB30.84605321
69MAPK150.84147555
70WEE10.83677546
71STK240.83065981
72NEK90.83053454
73PLK10.81518597
74FGFR30.80040487
75CSNK1G10.79885725
76BCR0.79681784
77PNCK0.78790749
78NUAK10.78603057
79BRD40.78241283
80MAP3K70.78128748
81CAMK1D0.73077288
82MAP2K20.72962886
83MAP3K30.72959291
84PRKCE0.70453075
85CHEK20.70255996
86CHEK10.69887152
87BRSK10.67432882
88MELK0.67278083
89DYRK1B0.66255407
90DYRK30.65246669
91PDK20.64855754
92CDK40.63919406
93DMPK0.63478237
94TNIK0.63200856
95PRKAA20.63140549
96TYRO30.62663486
97CDK190.62360104
98INSRR0.60512532
99TGFBR20.60037930
100ATR0.59078270
101PLK30.57226643
102PRKCI0.55855676
103PAK30.54952217
104SRPK10.54824107
105CSNK1E0.52809485
106PBK0.52762337
107KSR10.52139262
108YES10.51743234
109PIK3CG0.51442339
110ATM0.50758590
111MAP3K40.49562282
112CDK20.49435621
113TRPM70.49198976
114ROCK10.48701253
115TESK20.47574915
116MAPKAPK30.47140969
117NEK10.46523406
118ROCK20.46384774
119WNK10.44924436
120PAK10.44858174
121FLT30.44566768
122CDK90.44317430
123MAPK10.44259781
124TAF10.44249815
125AKT20.44224875
126FGFR40.42418638
127GSK3A0.42228799
128CSNK1D0.41932753
129PIK3CA0.41889094
130WNK30.41225418
131MKNK20.40916732
132CDK10.40904580
133ALK0.40500504
134AURKA0.39365480
135CDC42BPA0.39298713
136STK40.37686797
137CSNK1A1L0.37474971
138INSR0.36996391
139MAPK110.36237386
140LIMK10.35487610
141TRIM280.34566020
142MAP3K120.33980725
143MAPK70.33783205
144PRKAA10.33238515
145STK380.32827254
146KDR0.32489519
147MAP3K60.31860947
148ADRBK10.31333308
149SGK30.30090128

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.60880626
2Hedgehog signaling pathway_Homo sapiens_hsa043402.76506154
3Hippo signaling pathway_Homo sapiens_hsa043902.52609381
4ECM-receptor interaction_Homo sapiens_hsa045122.47633969
5One carbon pool by folate_Homo sapiens_hsa006702.18173693
6Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.07750792
7TGF-beta signaling pathway_Homo sapiens_hsa043502.00607555
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.94118817
9Bladder cancer_Homo sapiens_hsa052191.88589678
10Adherens junction_Homo sapiens_hsa045201.88257671
11Nitrogen metabolism_Homo sapiens_hsa009101.84857733
12Protein digestion and absorption_Homo sapiens_hsa049741.84789902
13MicroRNAs in cancer_Homo sapiens_hsa052061.83272502
14Proteoglycans in cancer_Homo sapiens_hsa052051.75932990
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.56145307
16Focal adhesion_Homo sapiens_hsa045101.53947409
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.49218906
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.47047047
19Lysine degradation_Homo sapiens_hsa003101.44690029
20Circadian rhythm_Homo sapiens_hsa047101.44630095
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.40615200
22Ribosome_Homo sapiens_hsa030101.39930559
23Cell cycle_Homo sapiens_hsa041101.39082048
24Wnt signaling pathway_Homo sapiens_hsa043101.36936659
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35451941
26Tight junction_Homo sapiens_hsa045301.34291331
27Small cell lung cancer_Homo sapiens_hsa052221.32061392
28Propanoate metabolism_Homo sapiens_hsa006401.29689565
29RNA transport_Homo sapiens_hsa030131.28584600
30Systemic lupus erythematosus_Homo sapiens_hsa053221.27717159
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25513317
32Sphingolipid metabolism_Homo sapiens_hsa006001.23948057
33Spliceosome_Homo sapiens_hsa030401.22844904
34Notch signaling pathway_Homo sapiens_hsa043301.22675397
35Selenocompound metabolism_Homo sapiens_hsa004501.16757190
36p53 signaling pathway_Homo sapiens_hsa041151.15590584
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13970773
38Steroid biosynthesis_Homo sapiens_hsa001001.13854383
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13759392
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12959247
41Melanoma_Homo sapiens_hsa052181.11588207
42Fat digestion and absorption_Homo sapiens_hsa049751.09601516
43Retinol metabolism_Homo sapiens_hsa008301.09163179
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06548245
45Chemical carcinogenesis_Homo sapiens_hsa052041.05709457
46Amoebiasis_Homo sapiens_hsa051461.02547161
47Thyroid hormone synthesis_Homo sapiens_hsa049181.01857212
48Pathways in cancer_Homo sapiens_hsa052001.01337474
49Tryptophan metabolism_Homo sapiens_hsa003801.01208029
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00194438
51Prostate cancer_Homo sapiens_hsa052150.99990758
52Histidine metabolism_Homo sapiens_hsa003400.97712902
53Arginine biosynthesis_Homo sapiens_hsa002200.97042589
54Mismatch repair_Homo sapiens_hsa034300.95958814
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95498554
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94564577
57mRNA surveillance pathway_Homo sapiens_hsa030150.94483524
58PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94422638
59Axon guidance_Homo sapiens_hsa043600.93913740
60DNA replication_Homo sapiens_hsa030300.92875459
61Complement and coagulation cascades_Homo sapiens_hsa046100.90628411
62Dilated cardiomyopathy_Homo sapiens_hsa054140.89151077
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87949761
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.86170160
65Thyroid cancer_Homo sapiens_hsa052160.85372243
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83730647
67Fatty acid degradation_Homo sapiens_hsa000710.82561474
68Vitamin digestion and absorption_Homo sapiens_hsa049770.82259399
69Melanogenesis_Homo sapiens_hsa049160.81721646
70N-Glycan biosynthesis_Homo sapiens_hsa005100.81664587
71Biosynthesis of amino acids_Homo sapiens_hsa012300.81526834
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80050436
73Tyrosine metabolism_Homo sapiens_hsa003500.79706019
74Pyruvate metabolism_Homo sapiens_hsa006200.79678515
75Chronic myeloid leukemia_Homo sapiens_hsa052200.79563579
76Renin-angiotensin system_Homo sapiens_hsa046140.79392524
77HTLV-I infection_Homo sapiens_hsa051660.78929032
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.77262092
79Mineral absorption_Homo sapiens_hsa049780.76845186
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76436992
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75961361
82beta-Alanine metabolism_Homo sapiens_hsa004100.75123420
83Phenylalanine metabolism_Homo sapiens_hsa003600.75004405
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73933412
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73426221
86ABC transporters_Homo sapiens_hsa020100.73400619
87Fatty acid metabolism_Homo sapiens_hsa012120.72336832
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72059555
89Glutathione metabolism_Homo sapiens_hsa004800.70960553
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.70017479
91Folate biosynthesis_Homo sapiens_hsa007900.68040157
92Bile secretion_Homo sapiens_hsa049760.67969980
93PPAR signaling pathway_Homo sapiens_hsa033200.67300018
94Viral carcinogenesis_Homo sapiens_hsa052030.67032185
95Arginine and proline metabolism_Homo sapiens_hsa003300.66813022
96Vitamin B6 metabolism_Homo sapiens_hsa007500.63684329
97Fatty acid elongation_Homo sapiens_hsa000620.62265534
98Nucleotide excision repair_Homo sapiens_hsa034200.62203236
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60484291
100Glucagon signaling pathway_Homo sapiens_hsa049220.60255733
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59138829
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58172686
103Starch and sucrose metabolism_Homo sapiens_hsa005000.55940432
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55224743
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54282740
106Pancreatic secretion_Homo sapiens_hsa049720.53928434
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53890695
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53320158
109Colorectal cancer_Homo sapiens_hsa052100.53304495
110Ovarian steroidogenesis_Homo sapiens_hsa049130.52703849
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52543008
112Rap1 signaling pathway_Homo sapiens_hsa040150.52241421
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.51887759
114Endometrial cancer_Homo sapiens_hsa052130.51210993
115Caffeine metabolism_Homo sapiens_hsa002320.50986969
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50145323
117AMPK signaling pathway_Homo sapiens_hsa041520.50006024
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48740877
119Glycerolipid metabolism_Homo sapiens_hsa005610.48536820
120Butanoate metabolism_Homo sapiens_hsa006500.47170199
121Inositol phosphate metabolism_Homo sapiens_hsa005620.47115243
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.45403043
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44365996
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44269967
125Non-homologous end-joining_Homo sapiens_hsa034500.43605128
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43197867
127Base excision repair_Homo sapiens_hsa034100.42953661
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42433872
129Sulfur metabolism_Homo sapiens_hsa009200.41732783
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41709531
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.40495348

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