LRIT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)9.94934419
2detection of light stimulus involved in visual perception (GO:0050908)9.94934419
3retinal rod cell development (GO:0046548)9.94016121
4photoreceptor cell development (GO:0042461)9.51046241
5photoreceptor cell maintenance (GO:0045494)9.13241387
6eye photoreceptor cell development (GO:0042462)9.06108668
7protein-chromophore linkage (GO:0018298)8.55809447
8phototransduction, visible light (GO:0007603)8.18012282
9phototransduction (GO:0007602)8.12072653
10detection of visible light (GO:0009584)7.98400262
11detection of light stimulus (GO:0009583)7.88719850
12visual perception (GO:0007601)6.92908586
13sensory perception of light stimulus (GO:0050953)6.85898654
14GMP metabolic process (GO:0046037)6.74800872
15positive regulation of guanylate cyclase activity (GO:0031284)5.81376482
16detection of external stimulus (GO:0009581)5.53845987
17cellular response to light stimulus (GO:0071482)5.53158441
18detection of abiotic stimulus (GO:0009582)5.43407738
19regulation of guanylate cyclase activity (GO:0031282)5.20078072
20eye photoreceptor cell differentiation (GO:0001754)5.15559921
21photoreceptor cell differentiation (GO:0046530)5.15559921
22retina development in camera-type eye (GO:0060041)4.81429197
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.59897588
24detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.38534223
25regulation of cGMP metabolic process (GO:0030823)4.33588046
26regulation of bile acid biosynthetic process (GO:0070857)4.12586205
27positive regulation of cGMP biosynthetic process (GO:0030828)4.07839797
28L-phenylalanine catabolic process (GO:0006559)3.94255887
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.94255887
30regulation of cGMP biosynthetic process (GO:0030826)3.80020585
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.66320982
32L-phenylalanine metabolic process (GO:0006558)3.66320982
33peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.64604016
34positive regulation of cGMP metabolic process (GO:0030825)3.51898656
35aromatic amino acid family catabolic process (GO:0009074)3.49672338
36nonmotile primary cilium assembly (GO:0035058)3.42891070
37cellular response to radiation (GO:0071478)3.41595781
38estrogen biosynthetic process (GO:0006703)3.40283835
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.34754812
40regulation of clathrin-mediated endocytosis (GO:2000369)3.33493333
41retinoid metabolic process (GO:0001523)3.31693942
42adaptation of signaling pathway (GO:0023058)3.28434149
43kynurenine metabolic process (GO:0070189)3.25890717
44sensory perception (GO:0007600)3.23788019
45alpha-linolenic acid metabolic process (GO:0036109)3.22363713
46diterpenoid metabolic process (GO:0016101)3.21037730
47dicarboxylic acid biosynthetic process (GO:0043650)3.20663721
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.19396292
49indole-containing compound catabolic process (GO:0042436)3.15770098
50indolalkylamine catabolic process (GO:0046218)3.15770098
51tryptophan catabolic process (GO:0006569)3.15770098
52bile acid biosynthetic process (GO:0006699)3.09241573
53regulation of short-term neuronal synaptic plasticity (GO:0048172)3.07917061
54terpenoid metabolic process (GO:0006721)3.05400940
55regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.01199259
56response to light stimulus (GO:0009416)3.01129420
57regulation of cholesterol homeostasis (GO:2000188)2.99731497
58negative regulation of receptor-mediated endocytosis (GO:0048261)2.99712844
59high-density lipoprotein particle remodeling (GO:0034375)2.99200738
60triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.98339487
61receptor guanylyl cyclase signaling pathway (GO:0007168)2.97613716
62negative regulation of cytosolic calcium ion concentration (GO:0051481)2.96856202
63urea cycle (GO:0000050)2.96056230
64urea metabolic process (GO:0019627)2.96056230
65response to pheromone (GO:0019236)2.94859803
66cellular potassium ion homeostasis (GO:0030007)2.91280442
67CDP-diacylglycerol biosynthetic process (GO:0016024)2.89807065
68tryptophan metabolic process (GO:0006568)2.88846689
69lipoprotein transport (GO:0042953)2.87561272
70regulation of voltage-gated calcium channel activity (GO:1901385)2.83187735
71neuron development (GO:0048666)2.82360656
72retina layer formation (GO:0010842)2.81950179
73protein localization to synapse (GO:0035418)2.79444187
74sodium ion export (GO:0071436)2.77704348
75regulation of protein activation cascade (GO:2000257)2.76326469
76retinol metabolic process (GO:0042572)2.75493635
77cell morphogenesis involved in neuron differentiation (GO:0048667)2.73542211
78triglyceride homeostasis (GO:0070328)2.70249582
79acylglycerol homeostasis (GO:0055090)2.70249582
80potassium ion homeostasis (GO:0055075)2.68564274
81glyoxylate metabolic process (GO:0046487)2.68102925
82glutamate metabolic process (GO:0006536)2.67247866
83membrane hyperpolarization (GO:0060081)2.64876164
84cholesterol efflux (GO:0033344)2.63615627
85bile acid metabolic process (GO:0008206)2.63454481
86complement activation, alternative pathway (GO:0006957)2.62745914
87nitrogen cycle metabolic process (GO:0071941)2.62649113
88detection of chemical stimulus involved in sensory perception (GO:0050907)2.62606073
89CDP-diacylglycerol metabolic process (GO:0046341)2.61956987
90fatty acid elongation (GO:0030497)2.61714921
91negative regulation of fibrinolysis (GO:0051918)2.60405435
92peptidyl-glutamic acid carboxylation (GO:0017187)2.60164093
93protein carboxylation (GO:0018214)2.60164093
94regulation of complement activation (GO:0030449)2.59789543
95reverse cholesterol transport (GO:0043691)2.55649170
96retina homeostasis (GO:0001895)2.53686302
97regulation of fibrinolysis (GO:0051917)2.52369812
98regulation of rhodopsin mediated signaling pathway (GO:0022400)12.7702238
99rhodopsin mediated signaling pathway (GO:0016056)12.7429730
100retinal cone cell development (GO:0046549)11.8341804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.57407655
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.44443427
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.41973385
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.28271552
5EGR1_23403033_ChIP-Seq_LIVER_Mouse2.86223296
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.74218396
7GBX2_23144817_ChIP-Seq_PC3_Human2.64544826
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.63412167
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.54280653
10CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.35740969
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81268576
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80038235
13DROSHA_22980978_ChIP-Seq_HELA_Human1.79753078
14AR_21572438_ChIP-Seq_LNCaP_Human1.70685087
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63914741
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.63145514
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55250765
18P53_22127205_ChIP-Seq_FIBROBLAST_Human1.54967415
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54289988
20REST_21632747_ChIP-Seq_MESCs_Mouse1.45834752
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42317974
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.42260837
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.42255729
24SMAD3_21741376_ChIP-Seq_HESCs_Human1.39949508
25HTT_18923047_ChIP-ChIP_STHdh_Human1.39734227
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39318253
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.38341920
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38157291
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37488261
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36090633
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35327452
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34733520
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34663088
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31762902
35VDR_22108803_ChIP-Seq_LS180_Human1.28275038
36SMAD4_21799915_ChIP-Seq_A2780_Human1.25427745
37AR_19668381_ChIP-Seq_PC3_Human1.24966239
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.23961752
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22738992
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18720348
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18291410
42EGR1_19032775_ChIP-ChIP_M12_Human1.17882771
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16753804
44BCAT_22108803_ChIP-Seq_LS180_Human1.15335755
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14669551
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13553458
47TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11435854
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.09621428
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09320423
50STAT3_23295773_ChIP-Seq_U87_Human1.08346627
51CTCF_27219007_Chip-Seq_Bcells_Human1.06751800
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.05798040
53TBL1_22424771_ChIP-Seq_293T_Human1.05483833
54P300_19829295_ChIP-Seq_ESCs_Human1.04420437
55IGF1R_20145208_ChIP-Seq_DFB_Human1.04318684
56SMAD4_21741376_ChIP-Seq_HESCs_Human1.04041580
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02966396
58* CBP_21632823_ChIP-Seq_H3396_Human1.02190341
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01832109
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01832109
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01362044
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01184893
63NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.99298705
64ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99121001
65HNF4A_19822575_ChIP-Seq_HepG2_Human0.97836744
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93994890
67KDM2B_26808549_Chip-Seq_K562_Human0.93806538
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93540099
69CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92232146
70CBP_20019798_ChIP-Seq_JUKART_Human0.91409797
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91409797
72EZH2_27304074_Chip-Seq_ESCs_Mouse0.88319851
73RING1B_27294783_Chip-Seq_NPCs_Mouse0.88039797
74FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86443266
75RNF2_27304074_Chip-Seq_ESCs_Mouse0.86431613
76FLI1_21867929_ChIP-Seq_TH2_Mouse0.86172825
77TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86125632
78NCOR_22424771_ChIP-Seq_293T_Human0.86115508
79TCF4_23295773_ChIP-Seq_U87_Human0.84980686
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84941993
81TCF4_18268006_ChIP-ChIP_LS174T_Human0.83578765
82SOX2_21211035_ChIP-Seq_LN229_Gbm0.82580185
83WDR5_24793694_ChIP-Seq_LNCAP_Human0.82141724
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81450208
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.81404223
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.80432501
87ER_23166858_ChIP-Seq_MCF-7_Human0.78638835
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78610382
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78422627
90TAF15_26573619_Chip-Seq_HEK293_Human0.77463248
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77310356
92JARID2_20064375_ChIP-Seq_MESCs_Mouse0.76957380
93EP300_21415370_ChIP-Seq_HL-1_Mouse0.76782663
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.76245492
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.75800594
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.75088172
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74948272
98ELK4_26923725_Chip-Seq_MESODERM_Mouse0.74879756
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74683701
100SMAD3_21741376_ChIP-Seq_EPCs_Human0.74506473

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation9.73782466
2MP0005551_abnormal_eye_electrophysiolog8.75267056
3MP0005253_abnormal_eye_physiology5.90925924
4MP0006072_abnormal_retinal_apoptosis5.57414507
5MP0002090_abnormal_vision3.56255063
6MP0005195_abnormal_posterior_eye3.51919369
7MP0001324_abnormal_eye_pigmentation3.17670062
8MP0002139_abnormal_hepatobiliary_system3.05715281
9MP0003950_abnormal_plasma_membrane3.01026648
10MP0005360_urolithiasis2.97893279
11MP0005391_vision/eye_phenotype2.86510564
12MP0005365_abnormal_bile_salt2.78269448
13MP0002229_neurodegeneration2.41366056
14MP0005085_abnormal_gallbladder_physiolo2.41049033
15MP0008875_abnormal_xenobiotic_pharmacok2.25823478
16MP0001764_abnormal_homeostasis2.24620061
17MP0002638_abnormal_pupillary_reflex2.17438457
18MP0004019_abnormal_vitamin_homeostasis2.01785751
19MP0003252_abnormal_bile_duct1.82224338
20MP0005423_abnormal_somatic_nervous1.79663262
21MP0002752_abnormal_somatic_nervous1.66228761
22MP0001502_abnormal_circadian_rhythm1.59921695
23MP0001984_abnormal_olfaction1.44340152
24MP0010329_abnormal_lipoprotein_level1.43952574
25MP0004233_abnormal_muscle_weight1.24230899
26MP0002653_abnormal_ependyma_morphology1.14108337
27MP0006292_abnormal_olfactory_placode1.13260761
28MP0002882_abnormal_neuron_morphology1.12523154
29MP0003868_abnormal_feces_composition1.11001544
30MP0009840_abnormal_foam_cell1.06773609
31MP0010368_abnormal_lymphatic_system0.95384372
32MP0001666_abnormal_nutrient_absorption0.94693913
33MP0001486_abnormal_startle_reflex0.94485809
34MP0005248_abnormal_Harderian_gland0.94061012
35MP0004782_abnormal_surfactant_physiolog0.93376941
36MP0004885_abnormal_endolymph0.87778934
37MP0005332_abnormal_amino_acid0.87664079
38MP0002332_abnormal_exercise_endurance0.87621481
39MP0005197_abnormal_uvea_morphology0.85656821
40MP0003806_abnormal_nucleotide_metabolis0.84188948
41MP0001986_abnormal_taste_sensitivity0.83412517
42MP0002118_abnormal_lipid_homeostasis0.80142429
43MP0005394_taste/olfaction_phenotype0.73128109
44MP0005499_abnormal_olfactory_system0.73128109
45MP0003195_calcinosis0.72958309
46MP0000609_abnormal_liver_physiology0.70792330
47MP0005083_abnormal_biliary_tract0.66255261
48MP0002272_abnormal_nervous_system0.64610973
49MP0005376_homeostasis/metabolism_phenot0.63998808
50MP0005319_abnormal_enzyme/_coenzyme0.63914943
51MP0004270_analgesia0.63139772
52MP0008789_abnormal_olfactory_epithelium0.61761468
53MP0003634_abnormal_glial_cell0.60599315
54MP0009697_abnormal_copulation0.57404082
55MP0002127_abnormal_cardiovascular_syste0.57187751
56MP0003880_abnormal_central_pattern0.56077952
57MP0005584_abnormal_enzyme/coenzyme_acti0.54467196
58MP0010386_abnormal_urinary_bladder0.53102491
59MP0005187_abnormal_penis_morphology0.52402063
60MP0002064_seizures0.52100963
61MP0003890_abnormal_embryonic-extraembry0.50445111
62MP0005220_abnormal_exocrine_pancreas0.47742708
63MP0005595_abnormal_vascular_smooth0.46742485
64MP0001286_abnormal_eye_development0.46563977
65MP0005670_abnormal_white_adipose0.44363222
66MP0004130_abnormal_muscle_cell0.43789481
67MP0002909_abnormal_adrenal_gland0.43339337
68MP0002067_abnormal_sensory_capabilities0.42880762
69MP0009046_muscle_twitch0.42045858
70MP0003635_abnormal_synaptic_transmissio0.41060124
71MP0002928_abnormal_bile_duct0.40603475
72MP0003191_abnormal_cellular_cholesterol0.39981216
73MP0009764_decreased_sensitivity_to0.39838818
74MP0001661_extended_life_span0.39827935
75MP0002078_abnormal_glucose_homeostasis0.38679231
76MP0002822_catalepsy0.38165120
77MP0004036_abnormal_muscle_relaxation0.37870233
78MP0004215_abnormal_myocardial_fiber0.37725514
79MP0005334_abnormal_fat_pad0.37700343
80MP0001963_abnormal_hearing_physiology0.37524552
81MP0002734_abnormal_mechanical_nocicepti0.37202175
82MP0004924_abnormal_behavior0.36389468
83MP0005386_behavior/neurological_phenoty0.36389468
84MP0000465_gastrointestinal_hemorrhage0.36371800
85MP0005535_abnormal_body_temperature0.35641593
86MP0001346_abnormal_lacrimal_gland0.35215914
87MP0002697_abnormal_eye_size0.35134831
88MP0002063_abnormal_learning/memory/cond0.34610982
89MP0005266_abnormal_metabolism0.34147174
90MP0001968_abnormal_touch/_nociception0.32709542
91MP0002138_abnormal_hepatobiliary_system0.31903684
92MP0008872_abnormal_physiological_respon0.31759323
93MP0004085_abnormal_heartbeat0.31427622
94MP0002971_abnormal_brown_adipose0.30667447
95MP0002572_abnormal_emotion/affect_behav0.28871571
96MP0004742_abnormal_vestibular_system0.28377168
97MP0008775_abnormal_heart_ventricle0.28194950
98MP0010030_abnormal_orbit_morphology0.27249875
99MP0003705_abnormal_hypodermis_morpholog0.27241108
100MP0003633_abnormal_nervous_system0.27197632

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.64848725
2Abnormal rod and cone electroretinograms (HP:0008323)9.23828721
3Central scotoma (HP:0000603)8.53161205
4Pigmentary retinal degeneration (HP:0001146)8.24560042
5Dyschromatopsia (HP:0007641)8.09161041
6Chorioretinal atrophy (HP:0000533)8.00435309
7Abnormality of macular pigmentation (HP:0008002)7.99248421
8Scotoma (HP:0000575)7.39349060
9Pendular nystagmus (HP:0012043)7.08054265
10Decreased central vision (HP:0007663)6.63129246
11Abolished electroretinogram (ERG) (HP:0000550)6.61436570
12Attenuation of retinal blood vessels (HP:0007843)6.39473412
13Photophobia (HP:0000613)5.06444948
14Type II diabetes mellitus (HP:0005978)5.04075159
15Cone-rod dystrophy (HP:0000548)5.03890923
16Posterior subcapsular cataract (HP:0007787)5.00984492
17Severe visual impairment (HP:0001141)4.91469422
18Macular degeneration (HP:0000608)4.89981009
19Vitreoretinal degeneration (HP:0000655)4.86456998
20Increased corneal curvature (HP:0100692)4.65190601
21Keratoconus (HP:0000563)4.65190601
22Constricted visual fields (HP:0001133)4.32540088
23Retinitis pigmentosa (HP:0000510)3.95189911
24Choroideremia (HP:0001139)3.84255520
25Decreased electroretinogram (ERG) amplitude (HP:0000654)3.54653639
26Subcapsular cataract (HP:0000523)3.20894706
27Progressive visual loss (HP:0000529)2.97488668
28Retinal atrophy (HP:0001105)2.87020054
29Intrahepatic cholestasis (HP:0001406)2.43592133
30Congenital sensorineural hearing impairment (HP:0008527)2.39561287
31Optic disc pallor (HP:0000543)2.28137895
32Deep venous thrombosis (HP:0002625)2.18717156
33Abnormality of aromatic amino acid family metabolism (HP:0004338)2.15681477
34Wide nasal bridge (HP:0000431)2.14537740
35Abnormality of monocarboxylic acid metabolism (HP:0010996)2.01937475
36Congenital stationary night blindness (HP:0007642)14.1507694
37Bony spicule pigmentary retinopathy (HP:0007737)10.5565918
38Polar cataract (HP:0010696)1.86945404
39Prolonged partial thromboplastin time (HP:0003645)1.84557468
40Gait imbalance (HP:0002141)1.82468040
41Hyperlipoproteinemia (HP:0010980)1.80959903
42Xanthomatosis (HP:0000991)1.80889104
43Congenital primary aphakia (HP:0007707)1.80130929
44Hypobetalipoproteinemia (HP:0003563)1.72863733
45Severe Myopia (HP:0011003)1.70815447
46Abnormal gallbladder physiology (HP:0012438)1.58667279
47Cholecystitis (HP:0001082)1.58667279
48Nephrogenic diabetes insipidus (HP:0009806)1.56579220
49Complement deficiency (HP:0004431)1.52048618
50Hypoalphalipoproteinemia (HP:0003233)1.48941802
51Epileptic encephalopathy (HP:0200134)1.48366340
52Optic atrophy (HP:0000648)1.47958750
53Poor coordination (HP:0002370)1.47830954
54Dysdiadochokinesis (HP:0002075)1.46854108
55Hypolipoproteinemia (HP:0010981)1.46453966
56Epidermoid cyst (HP:0200040)1.45398963
57Horizontal nystagmus (HP:0000666)1.45322701
58Medial flaring of the eyebrow (HP:0010747)1.44895696
59Abnormality of the common coagulation pathway (HP:0010990)1.43018530
60Febrile seizures (HP:0002373)1.34954746
61Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.29839715
62Interstitial pulmonary disease (HP:0006530)1.26670342
63Hyperammonemia (HP:0001987)1.23420967
64Vaginal atresia (HP:0000148)1.18521644
65Ketosis (HP:0001946)1.18437725
66Joint hemorrhage (HP:0005261)1.18214753
67Aplasia/Hypoplasia of the fovea (HP:0008060)1.17755236
68Hypoplasia of the fovea (HP:0007750)1.17755236
69Abnormality of the fovea (HP:0000493)1.16498618
70Fat malabsorption (HP:0002630)1.14665860
71Septo-optic dysplasia (HP:0100842)1.12798944
72Genital tract atresia (HP:0001827)1.12522501
73Abnormality of sulfur amino acid metabolism (HP:0004339)1.11808277
74Aplasia/Hypoplasia of the macula (HP:0008059)1.11793469
75Abnormality of methionine metabolism (HP:0010901)1.10446206
76Hyperglycinemia (HP:0002154)1.09969650
77Abnormality of glutamine family amino acid metabolism (HP:0010902)1.09863363
78True hermaphroditism (HP:0010459)1.08723006
79Hypercholesterolemia (HP:0003124)1.08195943
80Abnormality of aspartate family amino acid metabolism (HP:0010899)1.06418565
81Hypochromic microcytic anemia (HP:0004840)1.05718910
82Chronic hepatic failure (HP:0100626)1.03336454
83Aplasia/Hypoplasia of the lens (HP:0008063)1.03039856
84Aplasia/Hypoplasia affecting the retina (HP:0008061)1.02569169
85Conjugated hyperbilirubinemia (HP:0002908)1.01240412
86Retinal detachment (HP:0000541)1.00767169
87Progressive cerebellar ataxia (HP:0002073)1.00244908
88Abnormality of complement system (HP:0005339)1.00164802
89Hypoglycemic coma (HP:0001325)0.98482300
90Skin nodule (HP:0200036)0.97206313
91Abnormality of the lower motor neuron (HP:0002366)0.96156486
92Pancreatic fibrosis (HP:0100732)0.95859434
93Prolonged QT interval (HP:0001657)0.95512029
94Recurrent sinusitis (HP:0011108)0.95334971
95Vascular calcification (HP:0004934)0.93618568
96Status epilepticus (HP:0002133)0.93564195
97Hyperventilation (HP:0002883)0.91636383
98Aplasia/Hypoplasia of the tongue (HP:0010295)0.91583160
99Absence seizures (HP:0002121)0.90953966
100Cholelithiasis (HP:0001081)0.90592139

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK19.10347944
2PBK5.46618602
3PINK13.55470716
4INSRR2.48821706
5IRAK22.25484644
6CAMK1D1.91639335
7SIK11.90035837
8CAMK1G1.87507542
9TAOK31.77210162
10NEK11.66733308
11MAP3K101.63777713
12MAP3K41.63733732
13PAK61.58435113
14STK381.57234647
15SGK2231.47876465
16SGK4941.47876465
17SIK21.42675261
18MARK11.31497479
19MAP2K41.30182363
20ERBB21.29596387
21MAP3K71.28414551
22MAPK121.28049232
23MAPK71.20560187
24PRKCZ1.20402077
25BCKDK1.14274749
26HIPK21.13091885
27PRKAA11.12601149
28LATS11.10099745
29FRK1.09271337
30SGK21.05704750
31RIPK11.02513962
32BRD41.01286716
33SGK31.00205739
34ICK0.99384670
35PRKAA20.98779073
36AKT30.97606168
37DYRK1A0.95506245
38ADRBK10.94895285
39CSNK1D0.91108073
40CAMK2D0.90962082
41DYRK1B0.88511180
42CDK120.87812639
43PRKCH0.86525657
44MAP2K70.86129317
45STK38L0.85861855
46CDK30.84825249
47FGFR40.82200103
48PKN10.82107778
49PHKG20.80394224
50PHKG10.80394224
51PRKCB0.77237875
52PRKACG0.73595665
53PKN20.71469695
54CAMKK10.71426701
55CDK90.65813967
56RPS6KA30.64334416
57FES0.62455311
58FGFR20.60801340
59ERN10.60093134
60MINK10.59751871
61PRKD30.52190484
62CAMK40.51202492
63CAMK10.48731504
64RPS6KA40.47959326
65SGK10.47953380
66EPHA30.47665620
67MAP3K130.47494034
68PRKCA0.46128411
69PRPF4B0.44760434
70GSK3B0.44160377
71PRKD20.43979325
72TAOK20.43805247
73PNCK0.43243862
74PAK30.42540186
75PRKACA0.41337481
76PRKCG0.40958030
77MAPK100.40824039
78CAMK2A0.40580281
79CSNK1G20.40025943
80CDK50.39952702
81PDK10.39192443
82PIK3CA0.38933177
83AKT20.37261311
84MAPK140.36213979
85CSNK1E0.35745251
86MAPK90.35650676
87MAP3K60.33722716
88JAK10.33062844
89GRK50.32494131
90RPS6KB10.32439248
91CSNK1A1L0.31323418
92WNK10.31067008
93PRKG10.31022293
94MAPK110.30891168
95STK110.30630298
96PRKACB0.30104870
97PRKDC0.29971208
98RET0.29844213
99PTK60.29521116
100PRKD10.29256448

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.73639014
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.45955845
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.41684175
4Arginine biosynthesis_Homo sapiens_hsa002202.04851678
5Phototransduction_Homo sapiens_hsa0474412.2317304
6Retinol metabolism_Homo sapiens_hsa008301.73363393
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.63687991
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42089787
9Synaptic vesicle cycle_Homo sapiens_hsa047211.41565972
10GABAergic synapse_Homo sapiens_hsa047271.40165940
11ABC transporters_Homo sapiens_hsa020101.30953249
12Complement and coagulation cascades_Homo sapiens_hsa046101.29784471
13Caffeine metabolism_Homo sapiens_hsa002321.27996694
14Tryptophan metabolism_Homo sapiens_hsa003801.27365652
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25508256
16Olfactory transduction_Homo sapiens_hsa047401.23386181
17Fatty acid degradation_Homo sapiens_hsa000711.15211636
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14500347
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14035039
20Circadian rhythm_Homo sapiens_hsa047101.11976414
21Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09028881
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.06170049
23Bile secretion_Homo sapiens_hsa049761.03874664
24Butanoate metabolism_Homo sapiens_hsa006501.02311989
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01502645
26Peroxisome_Homo sapiens_hsa041460.98004173
27Biosynthesis of amino acids_Homo sapiens_hsa012300.95632304
28PPAR signaling pathway_Homo sapiens_hsa033200.90095508
29Fatty acid metabolism_Homo sapiens_hsa012120.90012757
30Steroid hormone biosynthesis_Homo sapiens_hsa001400.89134586
31Chemical carcinogenesis_Homo sapiens_hsa052040.86473409
32Fatty acid elongation_Homo sapiens_hsa000620.85238464
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84796104
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83643511
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83177156
36Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82314040
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81308459
38Morphine addiction_Homo sapiens_hsa050320.80341172
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77921244
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77521923
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77358579
42Phenylalanine metabolism_Homo sapiens_hsa003600.77337062
43Histidine metabolism_Homo sapiens_hsa003400.74188829
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73162929
45Lysine degradation_Homo sapiens_hsa003100.71029157
46Pyruvate metabolism_Homo sapiens_hsa006200.70429782
47Nicotine addiction_Homo sapiens_hsa050330.67779639
48Propanoate metabolism_Homo sapiens_hsa006400.67767333
49Glycerolipid metabolism_Homo sapiens_hsa005610.67240140
50beta-Alanine metabolism_Homo sapiens_hsa004100.66537375
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66190537
52Fructose and mannose metabolism_Homo sapiens_hsa000510.65186614
53Circadian entrainment_Homo sapiens_hsa047130.64278156
54Tyrosine metabolism_Homo sapiens_hsa003500.63849623
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62662925
56Starch and sucrose metabolism_Homo sapiens_hsa005000.62465199
57Glutamatergic synapse_Homo sapiens_hsa047240.62382111
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.61887767
59Carbon metabolism_Homo sapiens_hsa012000.60332011
60Fat digestion and absorption_Homo sapiens_hsa049750.60240030
61Staphylococcus aureus infection_Homo sapiens_hsa051500.60007997
62Cholinergic synapse_Homo sapiens_hsa047250.59984369
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.58113806
64Insulin secretion_Homo sapiens_hsa049110.53304914
65Selenocompound metabolism_Homo sapiens_hsa004500.50194152
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49594530
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49309771
68Dopaminergic synapse_Homo sapiens_hsa047280.43687593
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39878854
70Vitamin digestion and absorption_Homo sapiens_hsa049770.38856222
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.35947437
72Serotonergic synapse_Homo sapiens_hsa047260.35628310
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.33235342
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33099985
75Folate biosynthesis_Homo sapiens_hsa007900.32908041
76Arginine and proline metabolism_Homo sapiens_hsa003300.32814194
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32504632
78Pentose phosphate pathway_Homo sapiens_hsa000300.31995385
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31825265
80Galactose metabolism_Homo sapiens_hsa000520.29114660
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27131226
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26722477
83Salivary secretion_Homo sapiens_hsa049700.26446832
84Fatty acid biosynthesis_Homo sapiens_hsa000610.26315072
85Glucagon signaling pathway_Homo sapiens_hsa049220.26006698
86Renin secretion_Homo sapiens_hsa049240.23618233
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23487396
88Oxytocin signaling pathway_Homo sapiens_hsa049210.22919185
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.22768812
90Steroid biosynthesis_Homo sapiens_hsa001000.22007007
91Linoleic acid metabolism_Homo sapiens_hsa005910.21671343
92mTOR signaling pathway_Homo sapiens_hsa041500.21313544
93Sulfur metabolism_Homo sapiens_hsa009200.19575151
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19570677
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18323381
96AMPK signaling pathway_Homo sapiens_hsa041520.17878685
97Type II diabetes mellitus_Homo sapiens_hsa049300.17536236
98Insulin resistance_Homo sapiens_hsa049310.17087842
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14014950
100Inositol phosphate metabolism_Homo sapiens_hsa005620.13201989

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