LRIT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has a fibronectin type III domain and a C-terminal transmembrane domain, as well as a leucine-rich repeat domain and immunoglobulin-like domain near the N-terminus. The encoded protein may regulate fibroblast growth factor receptors and affect the modification of these receptors, which are glycosylated differently in the Golgi and endoplasmic reticulum. Mutations in this gene are associated with congenital stationary night blindness, type 1F. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of visible light (GO:0009584)9.97065584
2protein-chromophore linkage (GO:0018298)9.90299298
3visual perception (GO:0007601)8.45454745
4GMP metabolic process (GO:0046037)8.37963224
5sensory perception of light stimulus (GO:0050953)8.35707134
6retinal rod cell development (GO:0046548)7.77245251
7detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)7.57987625
8regulation of cGMP metabolic process (GO:0030823)7.28237583
9cellular response to light stimulus (GO:0071482)7.19931924
10detection of external stimulus (GO:0009581)7.14285669
11detection of abiotic stimulus (GO:0009582)7.00788791
12positive regulation of cGMP biosynthetic process (GO:0030828)6.76449303
13photoreceptor cell differentiation (GO:0046530)6.65333611
14eye photoreceptor cell differentiation (GO:0001754)6.65333611
15regulation of cGMP biosynthetic process (GO:0030826)6.37314603
16negative regulation of translation, ncRNA-mediated (GO:0040033)6.36166333
17regulation of translation, ncRNA-mediated (GO:0045974)6.36166333
18negative regulation of translation involved in gene silencing by miRNA (GO:0035278)6.36166333
19retina development in camera-type eye (GO:0060041)6.08691692
20positive regulation of cGMP metabolic process (GO:0030825)5.98982269
21synapsis (GO:0007129)5.90439680
22positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.82387554
23positive regulation of catecholamine secretion (GO:0033605)5.78760667
24regulation of glucocorticoid secretion (GO:2000849)5.62162620
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.62064239
26maturation of SSU-rRNA (GO:0030490)5.44546304
27locomotory exploration behavior (GO:0035641)5.29815877
28receptor guanylyl cyclase signaling pathway (GO:0007168)5.20728791
29male meiosis (GO:0007140)5.18201057
30cell morphogenesis involved in neuron differentiation (GO:0048667)5.09501031
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.97306221
32regulation of mitotic spindle checkpoint (GO:1903504)4.97306221
33DNA synthesis involved in DNA repair (GO:0000731)4.87370120
34regulation of corticosteroid hormone secretion (GO:2000846)4.65556337
35cellular response to radiation (GO:0071478)4.65275374
36positive regulation of calcium ion import (GO:0090280)4.56633624
37short-term memory (GO:0007614)4.47540813
38chromosome organization involved in meiosis (GO:0070192)4.43181744
39regulation of voltage-gated calcium channel activity (GO:1901385)4.43130820
40deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.42488798
41nonmotile primary cilium assembly (GO:0035058)4.38913986
42regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.34940758
43detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.33953059
44positive regulation of sodium ion transmembrane transporter activity (GO:2000651)4.28689590
45regulation of penile erection (GO:0060405)4.27650843
46germ cell migration (GO:0008354)4.24929352
47regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.23826244
48regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.23826244
49chemosensory behavior (GO:0007635)4.23429039
50transcription from mitochondrial promoter (GO:0006390)4.17808409
51piRNA metabolic process (GO:0034587)4.10713073
52parturition (GO:0007567)4.08428188
53behavioral response to ethanol (GO:0048149)4.08390798
54deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.03062519
55sensory perception (GO:0007600)3.97984013
56exploration behavior (GO:0035640)3.97544385
57male meiosis I (GO:0007141)3.97324328
58detection of chemical stimulus involved in sensory perception (GO:0050907)3.95948515
59response to histamine (GO:0034776)3.91768775
60response to light stimulus (GO:0009416)3.86599562
61synaptonemal complex assembly (GO:0007130)3.81247225
62positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.81173878
63prenylation (GO:0097354)3.80594606
64protein prenylation (GO:0018342)3.80594606
65DNA methylation involved in gamete generation (GO:0043046)3.72286478
66retina homeostasis (GO:0001895)3.72043248
67adaptation of signaling pathway (GO:0023058)3.71294128
68positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.68905640
69positive regulation of sodium ion transmembrane transport (GO:1902307)3.64973955
70regulation of gonadotropin secretion (GO:0032276)3.60427211
71meiosis I (GO:0007127)3.59777567
72regulation of clathrin-mediated endocytosis (GO:2000369)3.55721488
73neuron development (GO:0048666)3.54306503
74mitochondrial DNA replication (GO:0006264)3.54278374
75meiotic nuclear division (GO:0007126)3.51703382
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.49924860
77positive regulation of steroid hormone secretion (GO:2000833)3.47933948
78regulation of axon extension involved in axon guidance (GO:0048841)3.47751934
79regulation of spindle checkpoint (GO:0090231)3.46661487
80positive regulation of ERBB signaling pathway (GO:1901186)3.45782597
81phenylpropanoid metabolic process (GO:0009698)3.43644860
82positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.41925255
83interferon-gamma production (GO:0032609)3.39540476
84synaptonemal complex organization (GO:0070193)3.38569755
85alanine transport (GO:0032328)3.37581080
86positive regulation of neurotransmitter transport (GO:0051590)3.37213688
87response to misfolded protein (GO:0051788)3.34134418
88estrogen biosynthetic process (GO:0006703)3.28594578
89negative regulation of norepinephrine secretion (GO:0010700)3.24793145
90reciprocal DNA recombination (GO:0035825)3.24623487
91reciprocal meiotic recombination (GO:0007131)3.24623487
92negative regulation of circadian rhythm (GO:0042754)3.23042857
93pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.22935357
94pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.20382232
95regulation of cellular extravasation (GO:0002691)3.19801019
96positive regulation of digestive system process (GO:0060456)3.19091524
97behavioral response to cocaine (GO:0048148)3.18736622
982-deoxyribonucleotide biosynthetic process (GO:0009265)3.17182982
99deoxyribose phosphate biosynthetic process (GO:0046385)3.17182982
100membrane hyperpolarization (GO:0060081)3.13404608
101synaptic transmission, dopaminergic (GO:0001963)3.12141160
102regulation of mRNA 3-end processing (GO:0031440)3.10208705
103positive regulation of mRNA 3-end processing (GO:0031442)3.09483125
104regulation of dopamine secretion (GO:0014059)3.08065677
105icosanoid secretion (GO:0032309)3.05298742
106arachidonic acid secretion (GO:0050482)3.05298742
107positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.98512745
108regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.98512745
109peptidyl-histidine modification (GO:0018202)2.97162288
110somite development (GO:0061053)2.96732480
111retinoid metabolic process (GO:0001523)2.95800577
112regulation of axon guidance (GO:1902667)2.94354896
113regulation of neurotransmitter uptake (GO:0051580)2.94251149
114positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.93072585
115CDP-diacylglycerol biosynthetic process (GO:0016024)2.92340491
116glucocorticoid biosynthetic process (GO:0006704)2.90180022
117mitotic sister chromatid cohesion (GO:0007064)2.89481888
118retina layer formation (GO:0010842)2.89355694
119DNA-dependent DNA replication (GO:0006261)2.87152881
120regulation of steroid hormone secretion (GO:2000831)2.86407095
121positive regulation of mRNA processing (GO:0050685)2.86321212
122negative regulation of cation channel activity (GO:2001258)2.84675419
123negative regulation of gluconeogenesis (GO:0045721)2.83608687
124negative regulation of calcium ion transmembrane transport (GO:1903170)2.82781046
125negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.82781046
126protein heterotetramerization (GO:0051290)2.81754665
127positive regulation of cyclase activity (GO:0031281)2.80924175
128peptidyl-threonine dephosphorylation (GO:0035970)2.77137674
129translesion synthesis (GO:0019985)2.76775744
130meiotic cell cycle process (GO:1903046)2.75443330
131positive regulation of monocyte chemotaxis (GO:0090026)2.74855550
132diterpenoid metabolic process (GO:0016101)2.74730362
133positive regulation of protein homooligomerization (GO:0032464)2.74357212
134CDP-diacylglycerol metabolic process (GO:0046341)2.74218289
135regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.73805762
136regulation of catecholamine metabolic process (GO:0042069)2.72571807
137regulation of dopamine metabolic process (GO:0042053)2.72571807
138negative regulation of receptor-mediated endocytosis (GO:0048261)2.70969786
139protein targeting to mitochondrion (GO:0006626)2.69035857
140positive regulation of T cell cytokine production (GO:0002726)2.68819744
141DNA biosynthetic process (GO:0071897)2.68713863
142response to radiation (GO:0009314)2.68396933
143dopamine receptor signaling pathway (GO:0007212)2.68316958
144response to insecticide (GO:0017085)2.65480076
145mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.65303762
146regulation of short-term neuronal synaptic plasticity (GO:0048172)2.64900999
147pseudouridine synthesis (GO:0001522)2.62795494
148mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62211892
149mitochondrial respiratory chain complex I assembly (GO:0032981)2.62211892
150NADH dehydrogenase complex assembly (GO:0010257)2.62211892
151negative regulation of T cell mediated immunity (GO:0002710)2.60801258
152negative regulation of translational initiation (GO:0045947)2.60237949
153monoubiquitinated protein deubiquitination (GO:0035520)2.60161660
154meiotic chromosome segregation (GO:0045132)2.59901798
155negative regulation of catecholamine secretion (GO:0033604)2.59480833
156toxin metabolic process (GO:0009404)2.59384198
157negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.59155675
158resolution of meiotic recombination intermediates (GO:0000712)2.56904772
159protein neddylation (GO:0045116)2.56857337
160positive regulation of lyase activity (GO:0051349)2.54881901
161regulation of calcium ion import (GO:0090279)2.54370704
162regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.53533642
163positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.53533642
164histone H3-K4 methylation (GO:0051568)2.53329976
165terpenoid metabolic process (GO:0006721)2.51088381
166gene silencing by RNA (GO:0031047)2.50274174
167sister chromatid cohesion (GO:0007062)2.48167226
168microtubule nucleation (GO:0007020)2.47921779
169female gamete generation (GO:0007292)2.47635885
170fatty acid derivative transport (GO:1901571)2.47509267
171icosanoid transport (GO:0071715)2.47509267
172cellular response to electrical stimulus (GO:0071257)2.43400406
173retinol metabolic process (GO:0042572)2.43289947
174regulation of synaptic transmission, dopaminergic (GO:0032225)2.42837256
175protein localization to synapse (GO:0035418)2.42432471
176lipid translocation (GO:0034204)2.38982370
177phospholipid translocation (GO:0045332)2.38982370
178righting reflex (GO:0060013)2.37050748
179positive regulation of membrane potential (GO:0045838)2.37044014
180sensory perception of smell (GO:0007608)2.36629646
181cellular response to abiotic stimulus (GO:0071214)2.36176000
182regulation of rhodopsin mediated signaling pathway (GO:0022400)18.0879243
183retinal cone cell development (GO:0046549)18.0775688
184rhodopsin mediated signaling pathway (GO:0016056)17.4536414
185photoreceptor cell development (GO:0042461)12.0155738
186positive regulation of guanylate cyclase activity (GO:0031284)11.6660378
187eye photoreceptor cell development (GO:0042462)11.6653831
188detection of light stimulus involved in sensory perception (GO:0050962)11.2069668
189detection of light stimulus involved in visual perception (GO:0050908)11.2069668
190phototransduction (GO:0007602)10.8009934
191regulation of guanylate cyclase activity (GO:0031282)10.5800568
192photoreceptor cell maintenance (GO:0045494)10.5782853
193phototransduction, visible light (GO:0007603)10.4589009
194detection of light stimulus (GO:0009583)10.1712659

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.15484324
2E2F7_22180533_ChIP-Seq_HELA_Human4.63049557
3CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse4.05038572
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.40551479
5ZNF274_21170338_ChIP-Seq_K562_Hela3.39393765
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.39072048
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.16512809
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.16512809
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.16512809
10EZH2_22144423_ChIP-Seq_EOC_Human3.11578744
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.02801285
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.78315853
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.59616424
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55897295
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55743807
16DROSHA_22980978_ChIP-Seq_HELA_Human2.38585033
17GBX2_23144817_ChIP-Seq_PC3_Human2.35547466
18DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.27086687
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24763936
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.23650318
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22688511
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16909853
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.15955740
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04853505
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.03368059
26* VDR_22108803_ChIP-Seq_LS180_Human2.01242088
27BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.94728149
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87400092
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79163312
30SMAD3_21741376_ChIP-Seq_HESCs_Human1.77941627
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77192163
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75539681
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73269046
34TTF2_22483619_ChIP-Seq_HELA_Human1.72562625
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71384929
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.68136039
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.67080911
38AR_21572438_ChIP-Seq_LNCaP_Human1.66351187
39KDM2B_26808549_Chip-Seq_K562_Human1.65867421
40FOXP3_21729870_ChIP-Seq_TREG_Human1.63870214
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.62903605
42VDR_23849224_ChIP-Seq_CD4+_Human1.61941011
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59167862
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.58567983
45IGF1R_20145208_ChIP-Seq_DFB_Human1.58360952
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58237656
47RNF2_27304074_Chip-Seq_NSC_Mouse1.57143469
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.55333711
49KDM5A_27292631_Chip-Seq_BREAST_Human1.52240039
50NFYB_21822215_ChIP-Seq_K562_Human1.52115445
51REST_21632747_ChIP-Seq_MESCs_Mouse1.51900828
52ETV1_20927104_ChIP-Seq_GIST48_Human1.51607957
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50355148
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49049817
55PHF8_20622853_ChIP-Seq_HELA_Human1.48817224
56AR_19668381_ChIP-Seq_PC3_Human1.47587509
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43400268
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40939066
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40349433
60GABP_19822575_ChIP-Seq_HepG2_Human1.39981807
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.39801379
62CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.39728808
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.39288527
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39057148
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38603967
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38084586
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.36970028
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36731775
69EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36289751
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36289751
71TAF15_26573619_Chip-Seq_HEK293_Human1.36065707
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35751644
73RBPJ_21746931_ChIP-Seq_IB4_Human1.35724527
74RARB_27405468_Chip-Seq_BRAIN_Mouse1.35043960
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35011738
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34692103
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34634441
78NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.34472520
79TP53_22573176_ChIP-Seq_HFKS_Human1.33507733
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33027014
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32431887
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.31341491
83CTCF_27219007_Chip-Seq_Bcells_Human1.29605754
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.28383883
85SMC4_20622854_ChIP-Seq_HELA_Human1.28019365
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27186812
87TBL1_22424771_ChIP-Seq_293T_Human1.27080364
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.26849122
89POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24031951
90MYC_18940864_ChIP-ChIP_HL60_Human1.23270174
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.22594916
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21577054
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20930186
94ER_23166858_ChIP-Seq_MCF-7_Human1.19735477
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.19468179
96NFYA_21822215_ChIP-Seq_K562_Human1.18899731
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18514310
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18514310
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18133882
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.16126022
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.15298637
102PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15099014
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14469601
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13743450
105SMAD4_21799915_ChIP-Seq_A2780_Human1.13178026
106HNFA_21074721_ChIP-Seq_CACO-2_Human1.12586615
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11979877
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11271890
109CREB1_26743006_Chip-Seq_LNCaP_Human1.10577450
110GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10536312
111SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08943944
112WDR5_24793694_ChIP-Seq_LNCAP_Human1.08724742
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08389174
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08104496
115XRN2_22483619_ChIP-Seq_HELA_Human1.07570752
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.07425072
117EED_16625203_ChIP-ChIP_MESCs_Mouse1.06573910
118DCP1A_22483619_ChIP-Seq_HELA_Human1.06377718
119JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05802408
120ERG_20517297_ChIP-Seq_VCAP_Human1.05694337
121GATA2_21666600_ChIP-Seq_HMVEC_Human1.04811107
122STAT3_23295773_ChIP-Seq_U87_Human1.03815814
123ISL1_27105846_Chip-Seq_CPCs_Mouse1.03151702
124CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02897774
125OCT4_20526341_ChIP-Seq_ESCs_Human1.02788863
126PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02277902
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02137274
128THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01890816
129E2F1_20622854_ChIP-Seq_HELA_Human1.01813825
130TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01812368
131SRF_21415370_ChIP-Seq_HL-1_Mouse1.01807766
132GATA6_21074721_ChIP-Seq_CACO-2_Human1.01368050
133KDM2B_26808549_Chip-Seq_JURKAT_Human1.00612950
134* BCAT_22108803_ChIP-Seq_LS180_Human0.99608266
135MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98889673
136CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98081248
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97990679
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97720938
139RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97372644
140RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96897979
141TP63_19390658_ChIP-ChIP_HaCaT_Human0.96815511
142YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96765144
143CBX2_27304074_Chip-Seq_ESCs_Mouse0.96745199
144BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.96453843
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.96294883
146TAF2_19829295_ChIP-Seq_ESCs_Human0.95531209
147PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95110738
148CBP_21632823_ChIP-Seq_H3396_Human0.95037787
149YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94781232
150OCT4_19829295_ChIP-Seq_ESCs_Human0.94698578
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93990336
152* NANOG_20526341_ChIP-Seq_ESCs_Human0.93293668
153GF1_26923725_Chip-Seq_HPCs_Mouse0.93213386
154OCT1_27270436_Chip-Seq_PROSTATE_Human0.92586325
155CBX2_22325352_ChIP-Seq_293T-Rex_Human0.92496232
156VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92468636
157SA1_27219007_Chip-Seq_Bcells_Human0.92197401
158CTCF_20526341_ChIP-Seq_ESCs_Human0.91668262
159GATA1_26923725_Chip-Seq_HPCs_Mouse0.91424067
160HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91220337
161MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91155073
162MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90403875
163HTT_18923047_ChIP-ChIP_STHdh_Human0.90219244
164STAT1_17558387_ChIP-Seq_HELA_Human0.90047421
165DPY_21335234_ChIP-Seq_ESCs_Mouse0.89122435
166TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88910784
167FUS_26573619_Chip-Seq_HEK293_Human0.88592507
168TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88350705
169P300_19829295_ChIP-Seq_ESCs_Human0.88022676
170TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87731056
171CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87547727
172* NCOR_22424771_ChIP-Seq_293T_Human0.87320265
173ELF1_20517297_ChIP-Seq_JURKAT_Human0.87211306
174RING1B_27294783_Chip-Seq_ESCs_Mouse0.86865616
175* ERA_21632823_ChIP-Seq_H3396_Human0.86758462
176MYC_19079543_ChIP-ChIP_MESCs_Mouse0.86413162
177DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86190344
178STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.86141386
179VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85019199
180NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82650274
181P68_20966046_ChIP-Seq_HELA_Human0.82472988
182TCF4_23295773_ChIP-Seq_U87_Human0.81213305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.91904404
2MP0005253_abnormal_eye_physiology6.96471459
3MP0006072_abnormal_retinal_apoptosis6.58860215
4MP0009278_abnormal_bone_marrow4.20613482
5MP0008877_abnormal_DNA_methylation3.85987978
6MP0005195_abnormal_posterior_eye3.83057491
7MP0003950_abnormal_plasma_membrane3.59402348
8MP0008057_abnormal_DNA_replication3.45444961
9MP0001986_abnormal_taste_sensitivity3.38345941
10MP0003718_maternal_effect3.37066942
11MP0005391_vision/eye_phenotype3.34341982
12MP0005423_abnormal_somatic_nervous3.33509411
13MP0003123_paternal_imprinting3.24774865
14MP0001324_abnormal_eye_pigmentation3.19607511
15MP0002090_abnormal_vision2.91977123
16MP0002229_neurodegeneration2.52880380
17MP0008007_abnormal_cellular_replicative2.46960153
18MP0006276_abnormal_autonomic_nervous2.43003585
19MP0003693_abnormal_embryo_hatching2.40961846
20MP0002638_abnormal_pupillary_reflex2.36743308
21MP0001501_abnormal_sleep_pattern2.22635453
22MP0003121_genomic_imprinting2.15271967
23MP0003786_premature_aging2.06945792
24MP0003011_delayed_dark_adaptation10.8086875
25MP0002752_abnormal_somatic_nervous1.91378638
26MP0001764_abnormal_homeostasis1.83621889
27MP0003787_abnormal_imprinting1.79614000
28MP0002736_abnormal_nociception_after1.78674100
29MP0001545_abnormal_hematopoietic_system1.75332337
30MP0005397_hematopoietic_system_phenotyp1.75332337
31MP0002735_abnormal_chemical_nociception1.59313465
32MP0002249_abnormal_larynx_morphology1.59304280
33MP0005647_abnormal_sex_gland1.58043482
34MP0001919_abnormal_reproductive_system1.47643425
35MP0006036_abnormal_mitochondrial_physio1.47053542
36MP0000566_synostosis1.46848347
37MP0004019_abnormal_vitamin_homeostasis1.45813465
38MP0004808_abnormal_hematopoietic_stem1.43816480
39MP0006035_abnormal_mitochondrial_morpho1.38992225
40MP0002882_abnormal_neuron_morphology1.35186768
41MP0008995_early_reproductive_senescence1.35086251
42MP0002396_abnormal_hematopoietic_system1.35083521
43MP0003698_abnormal_male_reproductive1.32193868
44MP0002210_abnormal_sex_determination1.32051207
45MP0001929_abnormal_gametogenesis1.30251647
46MP0005395_other_phenotype1.27308520
47MP0010094_abnormal_chromosome_stability1.26235653
48MP0003077_abnormal_cell_cycle1.25136466
49MP0002653_abnormal_ependyma_morphology1.24171187
50MP0003136_yellow_coat_color1.23324831
51MP0005670_abnormal_white_adipose1.20870821
52MP0002733_abnormal_thermal_nociception1.20417195
53MP0000653_abnormal_sex_gland1.18243962
54MP0002876_abnormal_thyroid_physiology1.16640006
55MP0000372_irregular_coat_pigmentation1.16474879
56MP0001145_abnormal_male_reproductive1.16128912
57MP0000538_abnormal_urinary_bladder1.13508973
58MP0000639_abnormal_adrenal_gland1.12182651
59MP0003111_abnormal_nucleus_morphology1.09757441
60MP0005197_abnormal_uvea_morphology1.08439045
61MP0002127_abnormal_cardiovascular_syste1.05669306
62MP0004858_abnormal_nervous_system1.04100044
63MP0001984_abnormal_olfaction1.01254640
64MP0004233_abnormal_muscle_weight1.01064878
65MP0001970_abnormal_pain_threshold0.96547655
66MP0002332_abnormal_exercise_endurance0.92800964
67MP0003122_maternal_imprinting0.91565434
68MP0005410_abnormal_fertilization0.90076991
69MP0001119_abnormal_female_reproductive0.90001685
70MP0001346_abnormal_lacrimal_gland0.87693400
71MP0005499_abnormal_olfactory_system0.87037503
72MP0005394_taste/olfaction_phenotype0.87037503
73MP0000681_abnormal_thyroid_gland0.84877032
74MP0003632_abnormal_nervous_system0.84725536
75MP0004885_abnormal_endolymph0.84406896
76MP0004130_abnormal_muscle_cell0.84401193
77MP0000537_abnormal_urethra_morphology0.83341903
78MP0004270_analgesia0.83200091
79MP0005389_reproductive_system_phenotype0.81663588
80MP0000579_abnormal_nail_morphology0.81250659
81MP0002272_abnormal_nervous_system0.79597313
82MP0008789_abnormal_olfactory_epithelium0.78831945
83MP0002163_abnormal_gland_morphology0.78459809
84MP0001502_abnormal_circadian_rhythm0.78261127
85MP0001486_abnormal_startle_reflex0.77457759
86MP0004133_heterotaxia0.77422685
87MP0000955_abnormal_spinal_cord0.75366729
88MP0000049_abnormal_middle_ear0.74823790
89MP0000750_abnormal_muscle_regeneration0.74254024
90MP0004185_abnormal_adipocyte_glucose0.70141678
91MP0006292_abnormal_olfactory_placode0.69906900
92MP0002161_abnormal_fertility/fecundity0.69807479
93MP0001765_abnormal_ion_homeostasis0.69482539
94MP0009672_abnormal_birth_weight0.69297563
95MP0003119_abnormal_digestive_system0.69253623
96MP0002822_catalepsy0.69047595
97MP0005266_abnormal_metabolism0.68254388
98MP0005666_abnormal_adipose_tissue0.67291000
99MP0002970_abnormal_white_adipose0.66435565
100MP0003699_abnormal_female_reproductive0.65679875
101MP0005187_abnormal_penis_morphology0.65316598
102MP0003634_abnormal_glial_cell0.65250201
103MP0002734_abnormal_mechanical_nocicepti0.58558906
104MP0000465_gastrointestinal_hemorrhage0.56169001
105MP0008004_abnormal_stomach_pH0.55773472
106MP0004859_abnormal_synaptic_plasticity0.54136020
107MP0003880_abnormal_central_pattern0.54037556
108MP0003045_fibrosis0.51560758
109MP0004145_abnormal_muscle_electrophysio0.51041789
110MP0001905_abnormal_dopamine_level0.46459200
111MP0003635_abnormal_synaptic_transmissio0.44309892
112MP0002064_seizures0.44162397
113MP0003646_muscle_fatigue0.42684456
114MP0001963_abnormal_hearing_physiology0.42667619
115MP0001286_abnormal_eye_development0.42555036
116MP0005620_abnormal_muscle_contractility0.41450699
117MP0002572_abnormal_emotion/affect_behav0.39057485
118MP0009046_muscle_twitch0.38965789
119MP0005376_homeostasis/metabolism_phenot0.38920622
120MP0001968_abnormal_touch/_nociception0.38651938
121MP0005595_abnormal_vascular_smooth0.36833259
122MP0002063_abnormal_learning/memory/cond0.36049512
123MP0009745_abnormal_behavioral_response0.35637452
124MP0002067_abnormal_sensory_capabilities0.34931022
125MP0004215_abnormal_myocardial_fiber0.34176689
126MP0004085_abnormal_heartbeat0.33989915
127MP0004924_abnormal_behavior0.32871014
128MP0005386_behavior/neurological_phenoty0.32871014
129MP0004043_abnormal_pH_regulation0.32719406
130MP0001661_extended_life_span0.32410421
131MP0004782_abnormal_surfactant_physiolog0.32062176
132MP0003638_abnormal_response/metabolism_0.31513384
133MP0004142_abnormal_muscle_tone0.30896022
134MP0004742_abnormal_vestibular_system0.26569395
135MP0002168_other_aberrant_phenotype0.25967317
136MP0000631_abnormal_neuroendocrine_gland0.24682450
137MP0002108_abnormal_muscle_morphology0.24123043
138MP0000751_myopathy0.23489871
139MP0010386_abnormal_urinary_bladder0.22969626
140MP0003252_abnormal_bile_duct0.22224966
141MP0005076_abnormal_cell_differentiation0.21709977
142MP0005310_abnormal_salivary_gland0.20658793
143MP0005193_abnormal_anterior_eye0.19367392
144MP0002102_abnormal_ear_morphology0.18769595
145MP0005084_abnormal_gallbladder_morpholo0.18014606
146MP0000026_abnormal_inner_ear0.17875204
147MP0002152_abnormal_brain_morphology0.17489868
148MP0000767_abnormal_smooth_muscle0.16997103
149MP0002066_abnormal_motor_capabilities/c0.16728456
150MP0004811_abnormal_neuron_physiology0.16687129
151MP0000230_abnormal_systemic_arterial0.16198060
152MP0008569_lethality_at_weaning0.15402594
153MP0005330_cardiomyopathy0.15165488
154MP0005646_abnormal_pituitary_gland0.14795030
155MP0001915_intracranial_hemorrhage0.12351356
156MP0005365_abnormal_bile_salt0.12102207
157MP0002234_abnormal_pharynx_morphology0.12039702
158MP0002089_abnormal_postnatal_growth/wei0.11837864
159MP0004036_abnormal_muscle_relaxation0.11568723
160MP0001614_abnormal_blood_vessel0.11240429
161MP0009780_abnormal_chondrocyte_physiolo0.11122910
162MP0001177_atelectasis0.10802739
163MP0010030_abnormal_orbit_morphology0.10796412
164MP0002972_abnormal_cardiac_muscle0.10598846
165MP0010368_abnormal_lymphatic_system0.10478430
166MP0008875_abnormal_xenobiotic_pharmacok0.10153502
167MP0008058_abnormal_DNA_repair0.10033218
168MP0002557_abnormal_social/conspecific_i0.09383936

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)9.93607419
2Abnormality of macular pigmentation (HP:0008002)8.19136409
3Central scotoma (HP:0000603)7.68608534
4Attenuation of retinal blood vessels (HP:0007843)7.68494277
5Pendular nystagmus (HP:0012043)7.65993560
6Chorioretinal atrophy (HP:0000533)7.42043530
7Decreased central vision (HP:0007663)7.03834908
8Scotoma (HP:0000575)6.85026738
9Abolished electroretinogram (ERG) (HP:0000550)6.24293187
10Photophobia (HP:0000613)5.98277075
11Vitreoretinal degeneration (HP:0000655)5.75989879
12Type II diabetes mellitus (HP:0005978)5.67636701
13Macular degeneration (HP:0000608)5.55411685
14Severe visual impairment (HP:0001141)4.76063002
15Choroideremia (HP:0001139)4.73596617
16Increased corneal curvature (HP:0100692)4.50491617
17Keratoconus (HP:0000563)4.50491617
18Posterior subcapsular cataract (HP:0007787)4.44485114
19Abnormality of the labia minora (HP:0012880)4.43197243
20Type II lissencephaly (HP:0007260)4.42519821
21Retinitis pigmentosa (HP:0000510)4.25712250
22Cone-rod dystrophy (HP:0000548)4.05146476
23Cerebral hypomyelination (HP:0006808)3.85238897
24Constricted visual fields (HP:0001133)3.73437225
25Decreased electroretinogram (ERG) amplitude (HP:0000654)3.70445232
26Metaphyseal cupping (HP:0003021)3.48258195
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22093593
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22093593
29Metaphyseal dysplasia (HP:0100255)3.19819260
30Retinal dysplasia (HP:0007973)3.15188337
31Progressive visual loss (HP:0000529)2.98346168
32Abnormality of lateral ventricle (HP:0030047)2.92970634
33Abnormal tarsal ossification (HP:0008369)2.84071762
34Hypoplasia of the thymus (HP:0000778)2.81039943
35Osteomalacia (HP:0002749)2.78332722
36Panhypogammaglobulinemia (HP:0003139)2.76433345
37Polyphagia (HP:0002591)2.76011509
38Abnormality of the fingertips (HP:0001211)2.74344686
39Optic disc pallor (HP:0000543)2.72404265
40Azoospermia (HP:0000027)2.69078499
41Retinal atrophy (HP:0001105)2.68421653
42Microvesicular hepatic steatosis (HP:0001414)2.67926896
43Subcapsular cataract (HP:0000523)2.67777300
44Rimmed vacuoles (HP:0003805)2.59983998
45Abnormal hair whorl (HP:0010721)2.57536936
46Acute lymphatic leukemia (HP:0006721)2.57155068
47Generalized aminoaciduria (HP:0002909)2.57048689
48Abnormality of magnesium homeostasis (HP:0004921)2.54987498
49Congenital sensorineural hearing impairment (HP:0008527)2.54880385
50Wide nasal bridge (HP:0000431)2.52827599
51Failure to thrive in infancy (HP:0001531)2.43119733
52Hypomagnesemia (HP:0002917)2.35523653
53Growth hormone deficiency (HP:0000824)2.23117799
54Gait imbalance (HP:0002141)2.21880768
55Progressive external ophthalmoplegia (HP:0000590)2.21396145
56Limb dystonia (HP:0002451)2.19469281
57Congenital primary aphakia (HP:0007707)2.19321312
58Chromsome breakage (HP:0040012)2.16342935
59Keratoconjunctivitis (HP:0001096)2.15965729
60Keratoconjunctivitis sicca (HP:0001097)2.15136127
61Abnormal pupillary function (HP:0007686)2.09767521
62Retrobulbar optic neuritis (HP:0100654)2.08433074
63Optic neuritis (HP:0100653)2.08433074
64B lymphocytopenia (HP:0010976)2.07908113
65Volvulus (HP:0002580)2.07707339
66Orchitis (HP:0100796)2.01027116
67Protruding tongue (HP:0010808)2.00290260
68* Congenital stationary night blindness (HP:0007642)15.1295013
69Absent rod-and cone-mediated responses on ERG (HP:0007688)11.1335678
70Bony spicule pigmentary retinopathy (HP:0007737)11.0956633
71Dyschromatopsia (HP:0007641)11.0193926
72Abnormal rod and cone electroretinograms (HP:0008323)10.1578197
73Oligodontia (HP:0000677)1.96375345
74Gaze-evoked nystagmus (HP:0000640)1.96013212
75Intellectual disability, progressive (HP:0006887)1.95734472
76Prominent supraorbital ridges (HP:0000336)1.94965136
77Abnormal number of erythroid precursors (HP:0012131)1.94667452
78Clumsiness (HP:0002312)1.94632031
79Hepatocellular necrosis (HP:0001404)1.94559448
80Amyotrophic lateral sclerosis (HP:0007354)1.94030880
81Unsteady gait (HP:0002317)1.91852805
82Nephrogenic diabetes insipidus (HP:0009806)1.91755752
83Small hand (HP:0200055)1.91157881
84Abnormality of B cell number (HP:0010975)1.90435273
85Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88866055
86Sensory axonal neuropathy (HP:0003390)1.88833347
87CNS hypomyelination (HP:0003429)1.87729670
88Abnormality of calcium-phosphate metabolism (HP:0100530)1.87486526
89Hepatic necrosis (HP:0002605)1.86306210
90Testicular atrophy (HP:0000029)1.85625366
91Medial flaring of the eyebrow (HP:0010747)1.85175407
92Premature ovarian failure (HP:0008209)1.84627312
93Dysautonomia (HP:0002459)1.83567151
94Non-midline cleft lip (HP:0100335)1.82766531
95Sleep apnea (HP:0010535)1.82746439
96Widely patent fontanelles and sutures (HP:0004492)1.82697178
97Absent radius (HP:0003974)1.80859397
98External ophthalmoplegia (HP:0000544)1.80260915
99Self-mutilation (HP:0000742)1.80191974
100Stomach cancer (HP:0012126)1.80105256
101Pheochromocytoma (HP:0002666)1.79417033
102Abnormality of permanent molar morphology (HP:0011071)1.79045118
103Abnormality of the dental root (HP:0006486)1.79045118
104Taurodontia (HP:0000679)1.79045118
105Metabolic alkalosis (HP:0200114)1.78761672
106Delayed epiphyseal ossification (HP:0002663)1.78399319
107Anteriorly placed anus (HP:0001545)1.77781921
108Optic nerve coloboma (HP:0000588)1.77758795
109Areflexia of lower limbs (HP:0002522)1.74639237
110Hypercalciuria (HP:0002150)1.72824734
111Aplasia involving forearm bones (HP:0009822)1.71681147
112Absent forearm bone (HP:0003953)1.71681147
113Abnormal spermatogenesis (HP:0008669)1.71520468
114Increased circulating renin level (HP:0000848)1.71238102
115Impaired smooth pursuit (HP:0007772)1.70369791
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69336540
117Poor coordination (HP:0002370)1.67336342
118Alacrima (HP:0000522)1.66390957
119Abnormality of abdominal situs (HP:0011620)1.66135312
120Abdominal situs inversus (HP:0003363)1.66135312
121Postural instability (HP:0002172)1.65300202
122Pulmonary artery stenosis (HP:0004415)1.65167657
123Interstitial pulmonary disease (HP:0006530)1.60999796
124Optic atrophy (HP:0000648)1.59778270
125Horizontal nystagmus (HP:0000666)1.57458927
126True hermaphroditism (HP:0010459)1.55706106
127Vaginal atresia (HP:0000148)1.51968885
128Genital tract atresia (HP:0001827)1.45407883
129Polar cataract (HP:0010696)1.42862265
130Severe Myopia (HP:0011003)1.40980289
131Aplasia/Hypoplasia of the lens (HP:0008063)1.24122555
132Dysdiadochokinesis (HP:0002075)1.22597748
133Retinal detachment (HP:0000541)1.19209659
134Epileptic encephalopathy (HP:0200134)1.02833018
135Pancreatic fibrosis (HP:0100732)1.00223957
136Recurrent sinusitis (HP:0011108)0.96281270
137Abnormality of the fovea (HP:0000493)0.94912361
138Hypoplasia of the fovea (HP:0007750)0.94500628
139Aplasia/Hypoplasia of the fovea (HP:0008060)0.94500628
140Febrile seizures (HP:0002373)0.94427152
141Broad foot (HP:0001769)0.94225483
142Left ventricular hypertrophy (HP:0001712)0.94166369
143Astigmatism (HP:0000483)0.90478628
144Cerebellar dysplasia (HP:0007033)0.89980630
145Truncal ataxia (HP:0002078)0.89856189
146Specific learning disability (HP:0001328)0.87727488
147Decreased testicular size (HP:0008734)0.86432685
148Cystic liver disease (HP:0006706)0.85418625
149Progressive cerebellar ataxia (HP:0002073)0.83513411
150Sex reversal (HP:0012245)0.78636614
151Abnormal sex determination (HP:0012244)0.78636614
152Asthma (HP:0002099)0.77993285
153Aplasia/Hypoplasia of the macula (HP:0008059)0.77871916
154Visual hallucinations (HP:0002367)0.76202765
155Pancreatic cysts (HP:0001737)0.74167548
156Hypermetropia (HP:0000540)0.73204792
157Aplasia/Hypoplasia of the tongue (HP:0010295)0.72688962
158Chorioretinal coloboma (HP:0000567)0.72270829
159Sclerocornea (HP:0000647)0.71642594
160Aplasia/Hypoplasia affecting the retina (HP:0008061)0.71313212
161Partial agenesis of the corpus callosum (HP:0001338)0.70547759
162Aqueductal stenosis (HP:0002410)0.69437978
163Prolonged QT interval (HP:0001657)0.69220687
164Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.68262562
165Abnormality of dental color (HP:0011073)0.66628849
166Broad-based gait (HP:0002136)0.65855474
167Oligodactyly (hands) (HP:0001180)0.64735205
168Lymphopenia (HP:0001888)0.62027326
169Hypoventilation (HP:0002791)0.61490122
170Action tremor (HP:0002345)0.61008283
171Heterotopia (HP:0002282)0.60843855
172Dental crowding (HP:0000678)0.60398330
173Polycystic ovaries (HP:0000147)0.59853468
174Macroorchidism (HP:0000053)0.58663206
175Furrowed tongue (HP:0000221)0.57942629
176Genetic anticipation (HP:0003743)0.57885018
177Hypodontia (HP:0000668)0.57718618
178Cholecystitis (HP:0001082)0.57291383
179Abnormal gallbladder physiology (HP:0012438)0.57291383
180Short foot (HP:0001773)0.56771426
181Abnormality of cells of the lymphoid lineage (HP:0012140)0.55053530
182Postaxial hand polydactyly (HP:0001162)0.54835062
183Syncope (HP:0001279)0.53247098
184Abnormal EKG (HP:0003115)0.52989630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK7.11469012
2BUB15.07419429
3MKNK23.23572964
4CCNB13.00003201
5NUAK12.61586467
6INSRR2.50929536
7OXSR12.34069468
8MAPKAPK52.16982892
9DYRK32.08269628
10CDK192.03524139
11MAPK152.00156245
12GRK110.8501516
13PINK11.98396594
14TLK11.97016915
15ADRBK11.94740916
16ICK1.91465725
17ZAK1.87967965
18MKNK11.86250967
19CAMK1G1.83433297
20TAOK31.82993294
21MAPK71.77470138
22RPS6KA41.69988408
23IRAK21.67579847
24NEK91.66273510
25EIF2AK31.65169288
26MAP3K111.63074449
27CAMK1D1.59844185
28TGFBR21.50926085
29PLK11.48905981
30STK381.33784507
31CDK121.32365885
32ATR1.31472495
33WNK31.30167803
34SIK21.28986735
35PKN11.28616386
36STK101.28155950
37PRKCZ1.26307977
38TTK1.24572389
39CDK31.22770302
40HIPK21.17905506
41FGFR21.15443015
42PNCK1.15132356
43MAPK121.14605147
44EIF2AK21.13131064
45LATS11.12804763
46KIT1.10456843
47NEK21.10208400
48MARK11.08623719
49MYLK1.03693619
50TNK21.00822651
51NEK11.00437515
52CSNK1D1.00336893
53MAPKAPK30.99861201
54SGK4940.99798784
55SGK2230.99798784
56STK30.98951979
57CAMKK20.98903448
58CSF1R0.98714861
59TESK20.97927870
60EIF2AK10.97028353
61NME20.93772059
62MAP3K40.93422669
63BRD40.92458505
64MAP3K100.92427824
65PAK60.90820987
66CAMK2B0.87217022
67PHKG10.86510452
68PHKG20.86510452
69NME10.85791852
70UHMK10.84017877
71PAK10.80347575
72ADRBK20.79826126
73PRKCH0.78901734
74PRKD30.77063367
75WNK10.75822855
76ERBB20.75544616
77TRIM280.74147836
78CAMKK10.72029163
79PDK20.71362908
80MAPK110.70923216
81MAPK40.70209469
82EEF2K0.68657337
83PRKACG0.65511282
84PRKAA10.65455704
85DAPK20.65287501
86GRK50.64727840
87PRKCB0.61834703
88ILK0.61407511
89MAPKAPK20.61363810
90CHEK20.61334408
91GRK70.60628228
92RPS6KA50.58996990
93MAP3K90.58277801
94AKT20.56765376
95PDGFRB0.56365329
96SRPK10.55759164
97MOS0.55460402
98PRKAA20.54915148
99AKT30.54377289
100STK40.54360633
101CDK20.54042184
102RPS6KB20.53543570
103RPS6KA30.53490392
104SGK20.52861411
105PASK0.52763892
106ABL20.50813682
107CAMK2A0.50813336
108CAMK10.49497501
109TYK20.49249051
110SGK30.48408795
111STK110.47901761
112CAMK2D0.47550569
113PLK20.46925555
114PTK2B0.46913225
115DAPK10.46305636
116DYRK20.46249737
117PRKACB0.46220492
118AURKA0.43720490
119ATM0.43244838
120PRKDC0.43150490
121SCYL20.42840709
122FES0.42431118
123NEK60.42180808
124SGK10.41959863
125BRSK10.41669109
126PRKG10.40766144
127NTRK30.40576882
128TAOK10.40404296
129MAPK130.40085569
130STK38L0.38785743
131AURKB0.37774157
132DMPK0.36778634
133PRKD20.35372949
134PRKCG0.35302887
135GSK3B0.34805589
136DYRK1A0.34733266
137MAPK90.34031312
138CDK50.33592757
139PRKACA0.33415936
140MAPK140.33092054
141PLK30.32896593
142DYRK1B0.32895255
143MAP3K70.31297709
144FRK0.31062251
145CAMK40.30648462
146PRKCA0.28100686
147RPS6KB10.27430499
148CDK90.26696073
149MAPK100.26507523
150WNK40.24570350
151CDK10.23253037
152ALK0.22727077
153CSNK1E0.22660694
154MAP2K70.22086942
155MINK10.19983775
156IRAK10.19003702
157MAP2K40.17919655
158MAPK30.17389565
159NTRK20.16969585
160JAK10.16570180
161STK390.16284992
162CHEK10.15212526
163CDC42BPA0.14528717
164YES10.14204952
165PDK10.13132479
166SRC0.11968816

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.40681202
2Non-homologous end-joining_Homo sapiens_hsa034504.04886440
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.48992214
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.70381158
5Ribosome_Homo sapiens_hsa030102.44435640
6Folate biosynthesis_Homo sapiens_hsa007902.15327585
7Basal transcription factors_Homo sapiens_hsa030222.14362474
8RNA polymerase_Homo sapiens_hsa030202.01644279
9Phototransduction_Homo sapiens_hsa0474416.1370802
10Oxidative phosphorylation_Homo sapiens_hsa001901.96082615
11Sulfur relay system_Homo sapiens_hsa041221.95095129
12Parkinsons disease_Homo sapiens_hsa050121.89553095
13Selenocompound metabolism_Homo sapiens_hsa004501.86214230
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.82911139
15RNA transport_Homo sapiens_hsa030131.79186443
16Huntingtons disease_Homo sapiens_hsa050161.78021854
17Spliceosome_Homo sapiens_hsa030401.69595532
18Homologous recombination_Homo sapiens_hsa034401.63492037
19Pyrimidine metabolism_Homo sapiens_hsa002401.63487683
20Proteasome_Homo sapiens_hsa030501.55399359
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48760831
22Synaptic vesicle cycle_Homo sapiens_hsa047211.40324236
23Olfactory transduction_Homo sapiens_hsa047401.35209411
24Mismatch repair_Homo sapiens_hsa034301.34952042
25DNA replication_Homo sapiens_hsa030301.32685758
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30879151
27Alzheimers disease_Homo sapiens_hsa050101.30131171
28Oocyte meiosis_Homo sapiens_hsa041141.30055523
29Cell cycle_Homo sapiens_hsa041101.25155508
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25152261
31One carbon pool by folate_Homo sapiens_hsa006701.17993310
32Fanconi anemia pathway_Homo sapiens_hsa034601.04330357
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03476915
34GABAergic synapse_Homo sapiens_hsa047270.99149210
35Steroid biosynthesis_Homo sapiens_hsa001000.98542549
36Phenylalanine metabolism_Homo sapiens_hsa003600.95509609
37Regulation of autophagy_Homo sapiens_hsa041400.92090724
38Intestinal immune network for IgA production_Homo sapiens_hsa046720.91597888
39Nucleotide excision repair_Homo sapiens_hsa034200.91015691
40Retinol metabolism_Homo sapiens_hsa008300.88246776
41Butanoate metabolism_Homo sapiens_hsa006500.87872036
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87800194
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83905385
44Caffeine metabolism_Homo sapiens_hsa002320.80270214
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76332127
46Glutathione metabolism_Homo sapiens_hsa004800.73501191
47Cholinergic synapse_Homo sapiens_hsa047250.72861213
48Dopaminergic synapse_Homo sapiens_hsa047280.71162138
49Sphingolipid metabolism_Homo sapiens_hsa006000.70672304
50Arachidonic acid metabolism_Homo sapiens_hsa005900.70346036
51Primary immunodeficiency_Homo sapiens_hsa053400.69080611
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67837442
53Glutamatergic synapse_Homo sapiens_hsa047240.67048957
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66825353
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66691720
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65791978
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65377515
58Morphine addiction_Homo sapiens_hsa050320.65031126
59Circadian entrainment_Homo sapiens_hsa047130.62461707
60Nitrogen metabolism_Homo sapiens_hsa009100.62258391
61Tyrosine metabolism_Homo sapiens_hsa003500.61476529
62Circadian rhythm_Homo sapiens_hsa047100.59531116
63Base excision repair_Homo sapiens_hsa034100.58479747
64Tryptophan metabolism_Homo sapiens_hsa003800.57554705
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56368930
66Arginine biosynthesis_Homo sapiens_hsa002200.55881096
67Pyruvate metabolism_Homo sapiens_hsa006200.55515833
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54618457
69Serotonergic synapse_Homo sapiens_hsa047260.53165017
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52741656
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51076986
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50770710
73Linoleic acid metabolism_Homo sapiens_hsa005910.50151451
74Metabolic pathways_Homo sapiens_hsa011000.50066325
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50030740
76ABC transporters_Homo sapiens_hsa020100.49871453
77Insulin secretion_Homo sapiens_hsa049110.47408422
78Purine metabolism_Homo sapiens_hsa002300.46022669
79HTLV-I infection_Homo sapiens_hsa051660.45567587
80beta-Alanine metabolism_Homo sapiens_hsa004100.45564270
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45149343
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44322762
83RNA degradation_Homo sapiens_hsa030180.41234265
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38864282
85Nicotine addiction_Homo sapiens_hsa050330.35100365
86cAMP signaling pathway_Homo sapiens_hsa040240.34893102
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34231826
88Long-term depression_Homo sapiens_hsa047300.33875577
89mTOR signaling pathway_Homo sapiens_hsa041500.33455635
90Oxytocin signaling pathway_Homo sapiens_hsa049210.32127765
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32116548
92TGF-beta signaling pathway_Homo sapiens_hsa043500.31084434
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31083432
94Rheumatoid arthritis_Homo sapiens_hsa053230.31000583
95Herpes simplex infection_Homo sapiens_hsa051680.30899156
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29702265
97Dilated cardiomyopathy_Homo sapiens_hsa054140.29612145
98N-Glycan biosynthesis_Homo sapiens_hsa005100.28053214
99Gastric acid secretion_Homo sapiens_hsa049710.26542725
100Salivary secretion_Homo sapiens_hsa049700.26416246
101Fructose and mannose metabolism_Homo sapiens_hsa000510.26299234
102Inositol phosphate metabolism_Homo sapiens_hsa005620.26060794
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25005535
104Biosynthesis of amino acids_Homo sapiens_hsa012300.24391503
105Renin secretion_Homo sapiens_hsa049240.24001249
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22611119
107Cocaine addiction_Homo sapiens_hsa050300.22320485
108Cardiac muscle contraction_Homo sapiens_hsa042600.22233972
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.22011019
110Vitamin B6 metabolism_Homo sapiens_hsa007500.21594693
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21328142
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20073038
113Type II diabetes mellitus_Homo sapiens_hsa049300.19937614
114Glycerolipid metabolism_Homo sapiens_hsa005610.19910847
115Long-term potentiation_Homo sapiens_hsa047200.19529395
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.18665166
117Fatty acid elongation_Homo sapiens_hsa000620.18401933
118Glucagon signaling pathway_Homo sapiens_hsa049220.18183445
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.17770285
120Lysine degradation_Homo sapiens_hsa003100.16666721
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.16529543
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15676625
123Calcium signaling pathway_Homo sapiens_hsa040200.15032887
124HIF-1 signaling pathway_Homo sapiens_hsa040660.14467540
125Bile secretion_Homo sapiens_hsa049760.14130976
126Galactose metabolism_Homo sapiens_hsa000520.14104946
127AMPK signaling pathway_Homo sapiens_hsa041520.14049847
128Chemokine signaling pathway_Homo sapiens_hsa040620.13755270
129Amphetamine addiction_Homo sapiens_hsa050310.13729101
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13464209
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12157842
132Alcoholism_Homo sapiens_hsa050340.11315740
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.10527201
134Vitamin digestion and absorption_Homo sapiens_hsa049770.10291199
1352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.10013717
136Tight junction_Homo sapiens_hsa045300.08931159
137Taste transduction_Homo sapiens_hsa047420.08804804
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.08803402
139Insulin resistance_Homo sapiens_hsa049310.07905340
140Pancreatic secretion_Homo sapiens_hsa049720.07807640
141Ras signaling pathway_Homo sapiens_hsa040140.07612269
142Ovarian steroidogenesis_Homo sapiens_hsa049130.07291681
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.06813949
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.06765273
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06659397
146GnRH signaling pathway_Homo sapiens_hsa049120.06654173
147Thyroid hormone synthesis_Homo sapiens_hsa049180.06522805
148mRNA surveillance pathway_Homo sapiens_hsa030150.05893274
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.05696521
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.05696325
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.04863344
152Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.04676647
153Choline metabolism in cancer_Homo sapiens_hsa052310.04254440
154MAPK signaling pathway_Homo sapiens_hsa040100.03749740
155Collecting duct acid secretion_Homo sapiens_hsa049660.03629263
156Phospholipase D signaling pathway_Homo sapiens_hsa040720.03307000
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.03168705
158Adipocytokine signaling pathway_Homo sapiens_hsa049200.02756030
159Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.01993498
160Gap junction_Homo sapiens_hsa045400.01966496
161Hippo signaling pathway_Homo sapiens_hsa043900.01633465
162Glioma_Homo sapiens_hsa052140.01517938

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