LRMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.50589795
2B cell receptor signaling pathway (GO:0050853)5.82808422
3positive regulation of B cell differentiation (GO:0045579)5.47730557
4antigen processing and presentation of endogenous antigen (GO:0019883)4.96405039
5regulation of gamma-delta T cell differentiation (GO:0045586)4.88982838
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.76773419
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.76773419
8regulation of B cell receptor signaling pathway (GO:0050855)4.74079866
9regulation of B cell differentiation (GO:0045577)4.73223571
10regulation of gamma-delta T cell activation (GO:0046643)4.52334694
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.37825165
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.26723132
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.26723132
14modulation by symbiont of host immune response (GO:0052553)4.26723132
15positive regulation by symbiont of host defense response (GO:0052509)4.26723132
16modulation by symbiont of host defense response (GO:0052031)4.26723132
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.26723132
18macrophage activation involved in immune response (GO:0002281)4.04396296
19regulation of interferon-beta biosynthetic process (GO:0045357)3.99774401
20negative regulation of phagocytosis (GO:0050765)3.98248843
21ribosomal small subunit assembly (GO:0000028)3.94854673
22V(D)J recombination (GO:0033151)3.90653345
23mast cell activation (GO:0045576)3.76492884
24detection of other organism (GO:0098543)3.76220452
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.72522281
26T cell homeostasis (GO:0043029)3.71966452
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.71171464
28detection of bacterium (GO:0016045)3.69679100
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.67989713
30positive thymic T cell selection (GO:0045059)3.65631600
31leukocyte aggregation (GO:0070486)3.52523154
32mast cell degranulation (GO:0043303)3.43979652
33mast cell activation involved in immune response (GO:0002279)3.43979652
34neutrophil activation involved in immune response (GO:0002283)3.42887617
35antigen receptor-mediated signaling pathway (GO:0050851)3.42676262
36T cell migration (GO:0072678)3.42376059
37negative regulation of cell killing (GO:0031342)3.36116109
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.36116109
39hepatocyte apoptotic process (GO:0097284)3.36024800
40negative thymic T cell selection (GO:0045060)3.33803322
41lymphocyte homeostasis (GO:0002260)3.32496461
42cellular extravasation (GO:0045123)3.31706765
43negative T cell selection (GO:0043383)3.31656557
44regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.31285102
45regulation of histone H3-K9 methylation (GO:0051570)3.30803639
46detection of external biotic stimulus (GO:0098581)3.26943346
47interferon-gamma-mediated signaling pathway (GO:0060333)3.26299688
48negative regulation of T-helper cell differentiation (GO:0045623)3.24388811
49negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.24388811
50DNA unwinding involved in DNA replication (GO:0006268)3.22834541
51positive regulation of B cell proliferation (GO:0030890)3.22298409
52regulation of germinal center formation (GO:0002634)3.22035252
53immunoglobulin mediated immune response (GO:0016064)3.18867882
54B cell proliferation (GO:0042100)3.18331267
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.17846664
56positive regulation of interferon-alpha production (GO:0032727)3.17575084
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.16902519
58response to host immune response (GO:0052572)3.16902519
59cellular response to zinc ion (GO:0071294)3.15317227
60production of molecular mediator involved in inflammatory response (GO:0002532)3.14232368
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13738369
62response to peptidoglycan (GO:0032494)3.11943960
63negative regulation of lymphocyte mediated immunity (GO:0002707)3.11369526
64regulation of antigen processing and presentation (GO:0002577)3.10189300
65telomere maintenance via semi-conservative replication (GO:0032201)3.10180957
66respiratory burst (GO:0045730)3.09119141
67cellular response to type I interferon (GO:0071357)3.09041794
68type I interferon signaling pathway (GO:0060337)3.09041794
69CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.08535510
70neutrophil activation (GO:0042119)3.08268414
71regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07909372
72positive regulation of granulocyte differentiation (GO:0030854)3.07538804
73defense response to protozoan (GO:0042832)3.07391998
74natural killer cell differentiation (GO:0001779)3.07117540
75response to type I interferon (GO:0034340)3.07088451
76detection of molecule of bacterial origin (GO:0032490)3.07084224
77viral transcription (GO:0019083)3.03754576
78DNA strand elongation involved in DNA replication (GO:0006271)3.03397926
79leukocyte homeostasis (GO:0001776)3.03309526
80Peyers patch development (GO:0048541)3.01279794
81mucosal-associated lymphoid tissue development (GO:0048537)3.01279794
82response to interleukin-15 (GO:0070672)3.00635992
83positive regulation of protein homooligomerization (GO:0032464)2.99987624
84negative regulation of T cell mediated immunity (GO:0002710)2.99814035
85microglial cell activation (GO:0001774)2.98777178
86NIK/NF-kappaB signaling (GO:0038061)2.97407091
87T cell selection (GO:0045058)2.96393627
88myeloid dendritic cell activation (GO:0001773)2.95316953
89regulation of interferon-alpha production (GO:0032647)2.94679825
90regulation of alpha-beta T cell proliferation (GO:0046640)2.93565402
91positive regulation of mast cell activation (GO:0033005)2.92912033
92mature B cell differentiation (GO:0002335)2.92735189
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91619307
94response to host (GO:0075136)2.91619307
95response to host defenses (GO:0052200)2.91619307
96response to protozoan (GO:0001562)2.91497241
97DNA strand elongation (GO:0022616)2.90806139
98regulation of B cell activation (GO:0050864)2.88429581
99B cell homeostasis (GO:0001782)2.88308819
100positive T cell selection (GO:0043368)2.87426300
101regulation of interleukin-12 biosynthetic process (GO:0045075)2.86846012
102somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.85955087
103somatic cell DNA recombination (GO:0016444)2.85955087
104B cell activation (GO:0042113)2.85059226
105translational termination (GO:0006415)2.84825043
106tolerance induction (GO:0002507)2.84158717
107adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.83766010
108somatic diversification of immune receptors (GO:0002200)2.83697584
109regulation of mast cell degranulation (GO:0043304)2.83555986
110regulation of T cell receptor signaling pathway (GO:0050856)2.83349101
111detection of biotic stimulus (GO:0009595)2.82702508
112regulation of dendritic cell antigen processing and presentation (GO:0002604)2.81826332
113telomere maintenance via recombination (GO:0000722)2.81752252
114negative regulation of interleukin-12 production (GO:0032695)2.80794902
115thymic T cell selection (GO:0045061)2.78103756
116mitotic recombination (GO:0006312)2.77897593
117germinal center formation (GO:0002467)2.77342865
118regulation of B cell apoptotic process (GO:0002902)2.76627335
119B cell differentiation (GO:0030183)2.76479538
120immune response-activating cell surface receptor signaling pathway (GO:0002429)2.75846778
121positive regulation of B cell activation (GO:0050871)2.75052276
122cellular response to interleukin-15 (GO:0071350)2.73057928
123granulocyte activation (GO:0036230)2.72948080
124DNA topological change (GO:0006265)2.72272658
125mononuclear cell proliferation (GO:0032943)2.69739192
126negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.68872253
127lymphocyte proliferation (GO:0046651)2.68536548
128ribosomal small subunit biogenesis (GO:0042274)2.68149565
129negative regulation of B cell proliferation (GO:0030889)2.66319486
130cellular hyperosmotic response (GO:0071474)2.66056133
131B cell mediated immunity (GO:0019724)2.65843958
132T cell costimulation (GO:0031295)2.65743564
133regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.65529100
134regulation of B cell proliferation (GO:0030888)2.65367912
135protein localization to kinetochore (GO:0034501)2.63453415
136myeloid cell activation involved in immune response (GO:0002275)2.63434381
137antigen processing and presentation via MHC class Ib (GO:0002475)2.62831697
138positive regulation of interleukin-2 production (GO:0032743)2.62820218
139T cell receptor signaling pathway (GO:0050852)2.62205722
140negative regulation of histone methylation (GO:0031061)2.62189768
141lymphocyte costimulation (GO:0031294)2.61142790
142positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.60240819
143positive regulation of alpha-beta T cell proliferation (GO:0046641)2.58337809
144mature B cell differentiation involved in immune response (GO:0002313)2.58156390
145natural killer cell activation (GO:0030101)2.57480031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.79234524
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.25284335
3MYC_22102868_ChIP-Seq_BL_Human3.67071954
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.59534945
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.56233133
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.46478713
7* SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.35160023
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14637563
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.11357903
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.01051916
11VDR_21846776_ChIP-Seq_THP-1_Human3.00124786
12* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65229112
13* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.60487321
14SCL_19346495_ChIP-Seq_HPC-7_Human2.60206976
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.58635463
16* MYB_26560356_Chip-Seq_TH2_Human2.34570722
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32031512
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19840679
19* SPI1_23547873_ChIP-Seq_NB4_Human2.17318289
20MAF_26560356_Chip-Seq_TH1_Human2.16969648
21* IRF8_27001747_Chip-Seq_BMDM_Mouse2.15238018
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10324343
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10271959
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09802834
25RUNX_20019798_ChIP-Seq_JUKART_Human2.09317045
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.08322665
27UTX_26944678_Chip-Seq_JUKART_Human2.08263097
28* MYB_26560356_Chip-Seq_TH1_Human2.08229575
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06046608
30* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05967571
31MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04543017
32VDR_24763502_ChIP-Seq_THP-1_Human2.04528037
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.03012393
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98720106
35CIITA_25753668_ChIP-Seq_RAJI_Human1.97340079
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95147248
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.92368002
38* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92279545
39* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.92250835
40* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91290079
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90401799
42* RUNX1_22412390_ChIP-Seq_EML_Mouse1.80552270
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.72028416
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69845500
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.69544117
46TCF7_22412390_ChIP-Seq_EML_Mouse1.67712276
47* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65769700
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62701903
49* FOXP3_21729870_ChIP-Seq_TREG_Human1.55639292
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53319245
51* VDR_23849224_ChIP-Seq_CD4+_Human1.53062339
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48848089
53* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44203538
54SPI1_23127762_ChIP-Seq_K562_Human1.43516088
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.42146330
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41161734
57* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41144512
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.39181090
59MAF_26560356_Chip-Seq_TH2_Human1.38667119
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38039040
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36393347
62VDR_24787735_ChIP-Seq_THP-1_Human1.31259776
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.29128351
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.28825214
65* GATA3_27048872_Chip-Seq_THYMUS_Human1.27575684
66* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27358435
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25040194
68* GATA1_19941827_ChIP-Seq_MEL_Mouse1.24645371
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23905503
70* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22380012
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.20159156
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14311374
73GATA1_22025678_ChIP-Seq_K562_Human1.14136559
74XRN2_22483619_ChIP-Seq_HELA_Human1.11144339
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10221673
76PU_27001747_Chip-Seq_BMDM_Mouse1.09657246
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09244938
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09202268
79KDM2B_26808549_Chip-Seq_DND41_Human1.08897533
80* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08206291
81SMRT_27268052_Chip-Seq_Bcells_Human1.07776414
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.07312441
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06888507
84ELK1_19687146_ChIP-ChIP_HELA_Human1.04282043
85* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.03473180
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03298690
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.02272324
88NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02068875
89ETS1_20019798_ChIP-Seq_JURKAT_Human0.98806304
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98353194
91KDM5A_27292631_Chip-Seq_BREAST_Human0.97885966
92MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96988623
93NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96525944
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96042962
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95354103
96CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95200315
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94736732
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94377975
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93480556
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93049296
101TP63_19390658_ChIP-ChIP_HaCaT_Human0.92630941
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92512037
103CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91842710
104ELK3_25401928_ChIP-Seq_HUVEC_Human0.90208378
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89733058
106* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89149698
107RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88549159
108PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88163492
109GATA3_26560356_Chip-Seq_TH1_Human0.87643439
110GATA3_26560356_Chip-Seq_TH2_Human0.87471413
111PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86825214
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86004089
113* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85671832
114ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85427318
115FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84481310
116* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83786605
117CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82414667
118GATA1_19941826_ChIP-Seq_K562_Human0.81469009
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80111740
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75767041
121* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75654790
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74982961
123NCOR1_26117541_ChIP-Seq_K562_Human0.73794912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.35512090
2MP0001800_abnormal_humoral_immune3.72066882
3MP0000685_abnormal_immune_system3.48219884
4MP0005671_abnormal_response_to3.31941567
5MP0002396_abnormal_hematopoietic_system3.27913436
6MP0001790_abnormal_immune_system3.17657670
7MP0005387_immune_system_phenotype3.17657670
8MP0002452_abnormal_antigen_presenting3.07962094
9MP0003763_abnormal_thymus_physiology2.92728650
10MP0002398_abnormal_bone_marrow2.89173402
11MP0005000_abnormal_immune_tolerance2.88721983
12MP0002420_abnormal_adaptive_immunity2.82296231
13MP0002723_abnormal_immune_serum2.79851873
14MP0001819_abnormal_immune_cell2.77798567
15MP0003436_decreased_susceptibility_to2.73330037
16MP0009785_altered_susceptibility_to2.58314235
17MP0000689_abnormal_spleen_morphology2.53009546
18MP0000716_abnormal_immune_system2.50609323
19MP0003303_peritoneal_inflammation2.47718370
20MP0005025_abnormal_response_to2.41588449
21MP0002166_altered_tumor_susceptibility2.39502840
22MP0002722_abnormal_immune_system2.36348965
23MP0004808_abnormal_hematopoietic_stem2.26289677
24MP0010094_abnormal_chromosome_stability2.23421947
25MP0002148_abnormal_hypersensitivity_rea2.19887659
26MP0002419_abnormal_innate_immunity2.17621269
27MP0000703_abnormal_thymus_morphology2.16971718
28MP0002429_abnormal_blood_cell2.14588636
29MP0008057_abnormal_DNA_replication2.10772836
30MP0002405_respiratory_system_inflammati2.07244842
31MP0005464_abnormal_platelet_physiology2.06903889
32MP0003693_abnormal_embryo_hatching1.88470885
33MP0010155_abnormal_intestine_physiology1.87721825
34MP0009333_abnormal_splenocyte_physiolog1.83928767
35MP0002006_tumorigenesis1.82775312
36MP0001873_stomach_inflammation1.76363176
37MP0001853_heart_inflammation1.66790399
38MP0009278_abnormal_bone_marrow1.65788571
39MP0000465_gastrointestinal_hemorrhage1.64361927
40MP0000490_abnormal_crypts_of1.63668129
41MP0001545_abnormal_hematopoietic_system1.61744709
42MP0005397_hematopoietic_system_phenotyp1.61744709
43MP0003077_abnormal_cell_cycle1.60408958
44MP0003300_gastrointestinal_ulcer1.59508825
45MP0001845_abnormal_inflammatory_respons1.59140890
46MP0004947_skin_inflammation1.58642840
47MP0003111_abnormal_nucleus_morphology1.56180828
48MP0003866_abnormal_defecation1.54163077
49MP0002138_abnormal_hepatobiliary_system1.54144150
50MP0006082_CNS_inflammation1.44233141
51MP0002019_abnormal_tumor_incidence1.43090387
52MP0005174_abnormal_tail_pigmentation1.37248625
53MP0008058_abnormal_DNA_repair1.31813317
54MP0002933_joint_inflammation1.28604310
55MP0006054_spinal_hemorrhage1.24202547
56MP0005451_abnormal_body_composition1.23552697
57MP0003724_increased_susceptibility_to1.21149070
58MP0005310_abnormal_salivary_gland1.20244665
59MP0004957_abnormal_blastocyst_morpholog1.19930877
60MP0008007_abnormal_cellular_replicative1.17194214
61MP0010307_abnormal_tumor_latency1.15620150
62MP0005075_abnormal_melanosome_morpholog1.14402002
63MP0002095_abnormal_skin_pigmentation1.13877574
64MP0001533_abnormal_skeleton_physiology1.08916996
65MP0008260_abnormal_autophagy1.05948783
66MP0010352_gastrointestinal_tract_polyps1.04766120
67MP0008469_abnormal_protein_level1.01368470
68MP0000015_abnormal_ear_pigmentation1.00131667
69MP0003183_abnormal_peptide_metabolism0.94632399
70MP0002132_abnormal_respiratory_system0.90409145
71MP0004510_myositis0.89237458
72MP0000858_altered_metastatic_potential0.88675376
73MP0003045_fibrosis0.88206491
74MP0005645_abnormal_hypothalamus_physiol0.87630227
75MP0000313_abnormal_cell_death0.85495381
76MP0008004_abnormal_stomach_pH0.83761730
77MP0003172_abnormal_lysosome_physiology0.83722538
78MP0000350_abnormal_cell_proliferation0.80037116
79MP0003787_abnormal_imprinting0.78248139
80MP0003448_altered_tumor_morphology0.76676680
81MP0001986_abnormal_taste_sensitivity0.74454535
82MP0005166_decreased_susceptibility_to0.71901005
83MP0008877_abnormal_DNA_methylation0.69420644
84MP0001663_abnormal_digestive_system0.66550092
85MP0009763_increased_sensitivity_to0.63802344
86MP0005058_abnormal_lysosome_morphology0.63519227
87MP0003786_premature_aging0.63287276
88MP0001851_eye_inflammation0.61402993
89MP0003191_abnormal_cellular_cholesterol0.60775688
90MP0009765_abnormal_xenobiotic_induced0.60442138
91MP0004883_abnormal_blood_vessel0.60006153
92MP0003091_abnormal_cell_migration0.59065344
93MP0008874_decreased_physiological_sensi0.58025973
94MP0005076_abnormal_cell_differentiation0.57741694
95MP0000569_abnormal_digit_pigmentation0.57703829
96MP0003943_abnormal_hepatobiliary_system0.57599799
97MP0001879_abnormal_lymphatic_vessel0.57070646
98MP0003221_abnormal_cardiomyocyte_apopto0.56645922
99MP0002136_abnormal_kidney_physiology0.55606259
100MP0000477_abnormal_intestine_morphology0.55376068
101MP0002693_abnormal_pancreas_physiology0.54762120
102MP0001730_embryonic_growth_arrest0.54578395
103MP0002009_preneoplasia0.53702058
104MP0003075_altered_response_to0.52859491
105MP0009931_abnormal_skin_appearance0.52437387
106MP0008873_increased_physiological_sensi0.51508407
107MP0009764_decreased_sensitivity_to0.50404790
108MP0000249_abnormal_blood_vessel0.49344229
109MP0005621_abnormal_cell_physiology0.49305081
110MP0005266_abnormal_metabolism0.48375821
111MP0003828_pulmonary_edema0.47886264
112MP0002083_premature_death0.47862221
113MP0003252_abnormal_bile_duct0.46652564
114MP0004381_abnormal_hair_follicle0.45207100
115MP0000609_abnormal_liver_physiology0.44860392
116MP0006035_abnormal_mitochondrial_morpho0.44671392
117MP0003656_abnormal_erythrocyte_physiolo0.44600843
118MP0001915_intracranial_hemorrhage0.44589120
119MP0002998_abnormal_bone_remodeling0.44213877

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)7.51203012
2Cellulitis (HP:0100658)5.99363048
3Papilloma (HP:0012740)5.18345787
4Verrucae (HP:0200043)5.18345787
5Abnormality of B cell number (HP:0010975)5.17676004
6B lymphocytopenia (HP:0010976)5.17676004
7Panhypogammaglobulinemia (HP:0003139)5.16861507
8Recurrent viral infections (HP:0004429)5.01657840
9Recurrent bronchitis (HP:0002837)4.82100295
10Thyroiditis (HP:0100646)4.77458320
11Meningitis (HP:0001287)4.70386258
12IgM deficiency (HP:0002850)4.62694415
13Recurrent fungal infections (HP:0002841)4.09038968
14Chronic otitis media (HP:0000389)4.03202779
15Recurrent abscess formation (HP:0002722)3.99723885
16Chronic sinusitis (HP:0011109)3.92502880
17T lymphocytopenia (HP:0005403)3.92408389
18Severe combined immunodeficiency (HP:0004430)3.85811143
19Osteomyelitis (HP:0002754)3.85620025
20Colitis (HP:0002583)3.84349886
21Gastrointestinal stroma tumor (HP:0100723)3.84030054
22Abnormality of T cell number (HP:0011839)3.76855322
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.73251048
24Inflammation of the large intestine (HP:0002037)3.69829425
25Gastrointestinal inflammation (HP:0004386)3.66362935
26Recurrent bacterial skin infections (HP:0005406)3.64001035
27Combined immunodeficiency (HP:0005387)3.55392197
28IgG deficiency (HP:0004315)3.52190666
29Recurrent pneumonia (HP:0006532)3.50868999
30Lymphopenia (HP:0001888)3.49303231
31Recurrent sinusitis (HP:0011108)3.48901880
32Abnormality of T cells (HP:0002843)3.47993911
33Abnormality of cells of the lymphoid lineage (HP:0012140)3.40784047
34Sepsis (HP:0100806)3.40012042
35Eczematoid dermatitis (HP:0000976)3.23442282
36Recurrent lower respiratory tract infections (HP:0002783)3.20907854
37Optic neuritis (HP:0100653)3.13246229
38Retrobulbar optic neuritis (HP:0100654)3.13246229
39Chronic mucocutaneous candidiasis (HP:0002728)3.11212081
40Recurrent cutaneous fungal infections (HP:0011370)3.11212081
41Hypoplasia of the thymus (HP:0000778)3.10940283
42Gastrointestinal infarctions (HP:0005244)3.09556464
43Thrombocytosis (HP:0001894)3.06489324
44Viral hepatitis (HP:0006562)3.04438730
45Eosinophilia (HP:0001880)3.03457124
46Abnormality of T cell physiology (HP:0011840)3.00153177
47Orchitis (HP:0100796)2.98691597
48Small epiphyses (HP:0010585)2.95255007
49Vasculitis (HP:0002633)2.91975012
50Keratoconjunctivitis sicca (HP:0001097)2.91758768
51Abnormality of the fingertips (HP:0001211)2.88625337
52Elevated erythrocyte sedimentation rate (HP:0003565)2.86027880
53Recurrent skin infections (HP:0001581)2.84012365
54Lymphoma (HP:0002665)2.83831016
55Granulocytopenia (HP:0001913)2.83603045
56Chest pain (HP:0100749)2.80836432
57Mediastinal lymphadenopathy (HP:0100721)2.80567694
58Obstructive lung disease (HP:0006536)2.73148727
59Chronic obstructive pulmonary disease (HP:0006510)2.73148727
60Abnormality of eosinophils (HP:0001879)2.72896147
61Keratoconjunctivitis (HP:0001096)2.69389742
62Pulmonary infiltrates (HP:0002113)2.67155896
63Bronchitis (HP:0012387)2.64401763
64Urticaria (HP:0001025)2.63412342
65IgA deficiency (HP:0002720)2.62668644
66Recurrent otitis media (HP:0000403)2.61029931
67Skin rash (HP:0000988)2.54940225
68Autoimmune thrombocytopenia (HP:0001973)2.48831182
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.48698931
70Prolonged bleeding time (HP:0003010)2.46939463
71Increased IgM level (HP:0003496)2.46932901
72Petechiae (HP:0000967)2.46708769
73Gingival bleeding (HP:0000225)2.46593016
74Leukocytosis (HP:0001974)2.43907764
75Reticulocytopenia (HP:0001896)2.42988407
76Neutropenia (HP:0001875)2.42154434
77Myositis (HP:0100614)2.41482977
78Encephalitis (HP:0002383)2.37939201
79Emphysema (HP:0002097)2.37832933
80Hemoptysis (HP:0002105)2.33189439
81Arterial thrombosis (HP:0004420)2.32222909
82Nasal polyposis (HP:0100582)2.29744892
83Abnormality of the pleura (HP:0002103)2.29173551
84Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28945988
85Gingivitis (HP:0000230)2.28722134
86Abnormality of the peritoneum (HP:0002585)2.26535174
87Spontaneous hematomas (HP:0007420)2.24478898
88Skin ulcer (HP:0200042)2.24188885
89Acute hepatic failure (HP:0006554)2.22842459
90Abnormality of the intervertebral disk (HP:0005108)2.22734103
91Pustule (HP:0200039)2.22251102
92Abnormality of the prostate (HP:0008775)2.20122844
93Aplasia/Hypoplasia of the thymus (HP:0010515)2.19880698
94Leukopenia (HP:0001882)2.18383089
95Abnormality of cells of the erythroid lineage (HP:0012130)2.17211048
96Hypoproteinemia (HP:0003075)2.14013370
97Acute lymphatic leukemia (HP:0006721)2.11756785
98Pulmonary embolism (HP:0002204)2.11188709
99Restrictive lung disease (HP:0002091)2.10408499
100Abnormal number of erythroid precursors (HP:0012131)2.09707996
101Increased IgE level (HP:0003212)2.08901874
102Recurrent gram-negative bacterial infections (HP:0005420)2.01689169
103Abnormality of macrophages (HP:0004311)2.01017345
104Vertebral arch anomaly (HP:0008438)1.98472474
105Abnormality of male internal genitalia (HP:0000022)1.96584398
106Gangrene (HP:0100758)1.96421524
107Fatigue (HP:0012378)1.96381093
108Interstitial pulmonary disease (HP:0006530)1.94989422
109Amaurosis fugax (HP:0100576)1.94878274
110Periodontitis (HP:0000704)1.93183352
111Abnormality of the nasal mucosa (HP:0000433)1.91637161
112Stomatitis (HP:0010280)1.91583919
113Basal cell carcinoma (HP:0002671)1.90033215
114Hypochromic anemia (HP:0001931)1.89704835
115Chronic diarrhea (HP:0002028)1.85111728
116Agnosia (HP:0010524)1.83913815
117Epistaxis (HP:0000421)1.83446093
118Abnormality of the thymus (HP:0000777)1.82485996
119Poikiloderma (HP:0001029)1.81743002
120Abnormal platelet volume (HP:0011876)1.80300157
121Flattened epiphyses (HP:0003071)1.80067659
122Absent epiphyses (HP:0010577)1.77552161
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77552161
124Myelodysplasia (HP:0002863)1.76640038
125Autoimmune hemolytic anemia (HP:0001890)1.76588066

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.00350402
2MAP4K14.93868700
3BLK3.02924933
4EEF2K2.96463227
5GRK62.81452582
6BTK2.53209978
7SYK2.50323358
8CSF1R2.29404787
9PRPF4B2.08878967
10STK102.04595229
11KIT1.90021412
12RIPK41.86757615
13ERN11.85431827
14CLK11.84119281
15ZAP701.83877400
16TXK1.82062786
17TYK21.78370222
18TEC1.74508015
19MAP3K141.68926149
20BMPR21.66428830
21IRAK41.63290188
22ITK1.58226014
23STK41.56426118
24JAK31.52522076
25NEK21.51855740
26LYN1.48550911
27SIK21.48164081
28FES1.48009994
29CDC71.47446843
30HCK1.42970943
31LRRK21.39785358
32LCK1.36307171
33PIM11.30098183
34TLK11.29410331
35TBK11.27445490
36IKBKE1.22401108
37RPS6KB21.21972625
38CDK41.19403352
39PKN21.16865784
40TESK21.14091195
41IKBKB1.10372047
42FLT31.08262058
43CSK1.06117174
44BUB10.99202297
45SMG10.97904833
46EIF2AK30.97856017
47JAK10.96210896
48FGR0.95251091
49PIK3CG0.94460443
50CDK120.93888287
51NLK0.93446028
52MST40.92043201
53IRAK10.90791105
54TNK20.90770701
55NEK90.88848404
56PDK10.82885770
57NME20.81062053
58KSR20.80699590
59MAPK40.80647655
60IRAK20.79011204
61ATR0.77884581
62CDK190.75983732
63MAP3K130.74782493
64CDK90.74071456
65PRKCQ0.71237130
66FGFR30.69551970
67MAP2K30.68403754
68MAP3K80.68004788
69TRIB30.66498470
70MAPK110.65542764
71SCYL20.64599832
72BRD40.64518010
73RPS6KA40.63300968
74VRK10.62490080
75STK240.61434031
76CHUK0.61108421
77MARK30.60177998
78TGFBR10.58844974
79KDR0.58523183
80HIPK20.56466644
81TGFBR20.56062933
82PASK0.55878041
83MATK0.54114046
84RAF10.52863292
85TRPM70.51621986
86MAP3K10.50843201
87AURKB0.50194346
88PIM20.49961470
89WEE10.49837949
90DYRK30.49514539
91CDK60.47614106
92YES10.46446322
93TAOK30.46183801
94MAP3K70.44958559
95PDPK10.44002701
96FRK0.43737182
97MAPK120.43507630
98MAPKAPK20.43132492
99SIK30.43112482
100ARAF0.41935827
101FGFR40.40161937
102CHEK10.39734319
103MELK0.38350475
104FYN0.38262454
105CDC42BPA0.38226046
106JAK20.37999392
107MARK20.37586215
108RPS6KA50.37131001
109MAPK70.37080217
110CCNB10.36459291
111RPS6KA60.36014415
112MAPKAPK30.35552650
113SGK20.35442304
114TSSK60.35208934
115PRKCH0.34511849
116ABL10.33553566
117DYRK1B0.32413828
118EPHB10.32038320
119RPS6KB10.31955292
120MAP3K50.31816452
121SGK30.31587003
122MAPK30.28316037
123CDK70.27802012
124MAP3K110.26437117
125MAP3K30.24976914
126PTK2B0.22855548
127TAOK10.22854560

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.45544467
2B cell receptor signaling pathway_Homo sapiens_hsa046623.69613982
3DNA replication_Homo sapiens_hsa030303.09469043
4Non-homologous end-joining_Homo sapiens_hsa034502.67484914
5Mismatch repair_Homo sapiens_hsa034302.64362757
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.44716720
7Base excision repair_Homo sapiens_hsa034102.40582350
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.22538332
9Ribosome_Homo sapiens_hsa030102.03751713
10Hematopoietic cell lineage_Homo sapiens_hsa046402.00575087
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.00108824
12Antigen processing and presentation_Homo sapiens_hsa046121.96956800
13Leishmaniasis_Homo sapiens_hsa051401.96613104
14Osteoclast differentiation_Homo sapiens_hsa043801.92216756
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.92167336
16Measles_Homo sapiens_hsa051621.87770835
17Homologous recombination_Homo sapiens_hsa034401.76557775
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.75834058
19T cell receptor signaling pathway_Homo sapiens_hsa046601.69100081
20Spliceosome_Homo sapiens_hsa030401.52204901
21Herpes simplex infection_Homo sapiens_hsa051681.47766777
22Systemic lupus erythematosus_Homo sapiens_hsa053221.45845387
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44609000
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41193859
25Nucleotide excision repair_Homo sapiens_hsa034201.32935497
26Acute myeloid leukemia_Homo sapiens_hsa052211.28529379
27Cell cycle_Homo sapiens_hsa041101.25338795
28Fanconi anemia pathway_Homo sapiens_hsa034601.21976130
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21579616
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21236649
31Epstein-Barr virus infection_Homo sapiens_hsa051691.20346548
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17812095
33Viral carcinogenesis_Homo sapiens_hsa052031.17086200
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.16911216
35Allograft rejection_Homo sapiens_hsa053301.16845406
36Hepatitis B_Homo sapiens_hsa051611.13137476
37Chronic myeloid leukemia_Homo sapiens_hsa052201.11037017
38Apoptosis_Homo sapiens_hsa042101.10713277
39Non-small cell lung cancer_Homo sapiens_hsa052231.08171193
40Shigellosis_Homo sapiens_hsa051311.08048728
41Influenza A_Homo sapiens_hsa051641.06936781
42Chemokine signaling pathway_Homo sapiens_hsa040621.06181794
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.05616483
44Tuberculosis_Homo sapiens_hsa051521.05273778
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04865450
46Toxoplasmosis_Homo sapiens_hsa051451.04320536
47Platelet activation_Homo sapiens_hsa046111.04141445
48Rheumatoid arthritis_Homo sapiens_hsa053231.03099860
49Graft-versus-host disease_Homo sapiens_hsa053321.02771198
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99413912
51Legionellosis_Homo sapiens_hsa051340.92782636
52Pancreatic cancer_Homo sapiens_hsa052120.91995268
53Pyrimidine metabolism_Homo sapiens_hsa002400.90137255
54HTLV-I infection_Homo sapiens_hsa051660.88488766
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87346864
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85685495
57Pertussis_Homo sapiens_hsa051330.82949456
58Viral myocarditis_Homo sapiens_hsa054160.82555073
59p53 signaling pathway_Homo sapiens_hsa041150.79402443
60Asthma_Homo sapiens_hsa053100.78958206
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78253004
62Phagosome_Homo sapiens_hsa041450.76081917
63One carbon pool by folate_Homo sapiens_hsa006700.75730551
64RNA transport_Homo sapiens_hsa030130.75140907
65RNA degradation_Homo sapiens_hsa030180.72537832
66mRNA surveillance pathway_Homo sapiens_hsa030150.68886280
67Malaria_Homo sapiens_hsa051440.67472520
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67400861
69Small cell lung cancer_Homo sapiens_hsa052220.65824411
70TNF signaling pathway_Homo sapiens_hsa046680.64718951
71Other glycan degradation_Homo sapiens_hsa005110.64472479
72Colorectal cancer_Homo sapiens_hsa052100.64153286
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63134316
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.62287485
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61925959
76Staphylococcus aureus infection_Homo sapiens_hsa051500.60821491
77RNA polymerase_Homo sapiens_hsa030200.59317009
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58331414
79Salmonella infection_Homo sapiens_hsa051320.57433936
80VEGF signaling pathway_Homo sapiens_hsa043700.55071891
81Renal cell carcinoma_Homo sapiens_hsa052110.54090415
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53693935
83Autoimmune thyroid disease_Homo sapiens_hsa053200.52918002
84Hepatitis C_Homo sapiens_hsa051600.52656239
85Alcoholism_Homo sapiens_hsa050340.50929263
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49286909
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49055372
88Dorso-ventral axis formation_Homo sapiens_hsa043200.48810735
89Pentose phosphate pathway_Homo sapiens_hsa000300.48710692
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.47899330
91Proteasome_Homo sapiens_hsa030500.45189912
92MicroRNAs in cancer_Homo sapiens_hsa052060.45119521
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45021330
94Inositol phosphate metabolism_Homo sapiens_hsa005620.44337167
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43740362
96Choline metabolism in cancer_Homo sapiens_hsa052310.39551856
97FoxO signaling pathway_Homo sapiens_hsa040680.38664592
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.38421124
99Endometrial cancer_Homo sapiens_hsa052130.36760797
100Prolactin signaling pathway_Homo sapiens_hsa049170.34858029
101HIF-1 signaling pathway_Homo sapiens_hsa040660.34576829
102Renin-angiotensin system_Homo sapiens_hsa046140.34450348
103Prostate cancer_Homo sapiens_hsa052150.33661158
104Glioma_Homo sapiens_hsa052140.33576062
105Notch signaling pathway_Homo sapiens_hsa043300.33571978
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33284337
107Basal transcription factors_Homo sapiens_hsa030220.31990293
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.29748364
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29538849
110N-Glycan biosynthesis_Homo sapiens_hsa005100.28620790
111Type I diabetes mellitus_Homo sapiens_hsa049400.27918283
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27613975
113mTOR signaling pathway_Homo sapiens_hsa041500.27352790
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27326617
115Purine metabolism_Homo sapiens_hsa002300.26658456
116African trypanosomiasis_Homo sapiens_hsa051430.26070710
117MAPK signaling pathway_Homo sapiens_hsa040100.24669194
118GnRH signaling pathway_Homo sapiens_hsa049120.23932782
119Insulin resistance_Homo sapiens_hsa049310.23555040
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.23409527
121Long-term potentiation_Homo sapiens_hsa047200.20574282

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