LRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.00500665
2* apoptotic cell clearance (GO:0043277)3.95718459
3regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.93650664
4mannose metabolic process (GO:0006013)3.75916896
5barbed-end actin filament capping (GO:0051016)3.72103336
6neuron projection extension involved in neuron projection guidance (GO:1902284)3.68398306
7axon extension involved in axon guidance (GO:0048846)3.68398306
8protein carboxylation (GO:0018214)3.55321266
9peptidyl-glutamic acid carboxylation (GO:0017187)3.55321266
10extracellular matrix assembly (GO:0085029)3.55113281
11adhesion of symbiont to host cell (GO:0044650)3.53768859
12virion attachment to host cell (GO:0019062)3.53768859
13positive regulation of fatty acid beta-oxidation (GO:0032000)3.53059318
14complement activation, alternative pathway (GO:0006957)3.49790400
15cell migration involved in heart development (GO:0060973)3.45042732
16extracellular fibril organization (GO:0043206)3.40766445
17cell adhesion mediated by integrin (GO:0033627)3.30384918
18phospholipid homeostasis (GO:0055091)3.27948703
19adhesion of symbiont to host (GO:0044406)3.26572185
20negative regulation of fibrinolysis (GO:0051918)3.25203666
21collagen fibril organization (GO:0030199)3.24793209
22regulation of fatty acid beta-oxidation (GO:0031998)3.23923595
23endodermal cell differentiation (GO:0035987)3.21269472
24fibril organization (GO:0097435)3.21262748
25protein heterotrimerization (GO:0070208)3.21057138
26alpha-linolenic acid metabolic process (GO:0036109)3.19507763
27low-density lipoprotein particle clearance (GO:0034383)3.18527428
28positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.14957863
29positive regulation of p38MAPK cascade (GO:1900745)3.14124472
30regulation of extracellular matrix disassembly (GO:0010715)3.13833027
31regulation of cholesterol storage (GO:0010885)3.10264159
32regulation of protein activation cascade (GO:2000257)3.09643994
33regulation of complement activation (GO:0030449)3.05119159
34plasma membrane repair (GO:0001778)3.04759753
35positive regulation of extracellular matrix organization (GO:1903055)3.00659342
36regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.00149704
37positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.00066176
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.95023037
39regulation of integrin activation (GO:0033623)2.87968195
40plasma lipoprotein particle clearance (GO:0034381)2.86445321
41urea cycle (GO:0000050)2.81665106
42urea metabolic process (GO:0019627)2.81665106
43macroautophagy (GO:0016236)2.79591839
44positive regulation of fatty acid oxidation (GO:0046321)2.79324634
45protein localization to endosome (GO:0036010)2.78593742
46regulation of apoptotic cell clearance (GO:2000425)2.77561746
47cell-substrate junction assembly (GO:0007044)2.77065952
48regulation of fibrinolysis (GO:0051917)2.73566595
49insulin-like growth factor receptor signaling pathway (GO:0048009)2.73515017
50glomerular basement membrane development (GO:0032836)2.72849053
51venous blood vessel morphogenesis (GO:0048845)2.72609775
52positive regulation of endothelial cell apoptotic process (GO:2000353)2.72165187
53planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71184810
54positive regulation of lipid catabolic process (GO:0050996)2.70195315
55regulation of cholesterol homeostasis (GO:2000188)2.69545369
56tooth mineralization (GO:0034505)2.65548079
57dermatan sulfate metabolic process (GO:0030205)2.63877603
58positive regulation of receptor recycling (GO:0001921)2.63049776
59chondroitin sulfate catabolic process (GO:0030207)2.62968708
60positive regulation by organism of defense response of other organism involved in symbiotic interact2.60976901
61modulation by symbiont of host immune response (GO:0052553)2.60976901
62positive regulation by symbiont of host defense response (GO:0052509)2.60976901
63modulation by symbiont of host defense response (GO:0052031)2.60976901
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.60976901
65modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.60976901
66substrate-dependent cell migration (GO:0006929)2.60268001
67regulation of membrane protein ectodomain proteolysis (GO:0051043)2.60247876
68sequestering of extracellular ligand from receptor (GO:0035581)2.59427885
69alanine transport (GO:0032328)2.59035063
70cortical cytoskeleton organization (GO:0030865)2.58681349
71type B pancreatic cell proliferation (GO:0044342)2.58529752
72collagen metabolic process (GO:0032963)2.58309431
73skin morphogenesis (GO:0043589)2.57487231
74collagen catabolic process (GO:0030574)2.57457944
75regulation of p38MAPK cascade (GO:1900744)2.57342594
76response to fluid shear stress (GO:0034405)2.57245828
77positive regulation of fibroblast migration (GO:0010763)2.57137479
78cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.55388195
79fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.55064982
80dermatan sulfate biosynthetic process (GO:0030208)2.54747842
81adherens junction assembly (GO:0034333)2.54151042
82retina vasculature morphogenesis in camera-type eye (GO:0061299)2.53622795
83dicarboxylic acid biosynthetic process (GO:0043650)2.52735958
84kidney mesenchyme development (GO:0072074)2.52152156
85regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.51162216
86multicellular organismal macromolecule metabolic process (GO:0044259)2.50053250
87positive regulation of blood coagulation (GO:0030194)2.48221619
88positive regulation of hemostasis (GO:1900048)2.48221619
89basement membrane organization (GO:0071711)2.48192406
90chondroitin sulfate biosynthetic process (GO:0030206)2.47734257
91metanephric mesenchyme development (GO:0072075)2.47207413
92phospholipid efflux (GO:0033700)2.47092547
93cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.46465294
94nitrogen cycle metabolic process (GO:0071941)2.44461748
95heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.43770560
96extracellular matrix organization (GO:0030198)2.43257640
97protein-lipid complex assembly (GO:0065005)2.42748462
98extracellular structure organization (GO:0043062)2.42191119
99cellular response to vitamin (GO:0071295)2.40447058
100negative regulation of fatty acid transport (GO:2000192)2.40140577
101cytoskeletal anchoring at plasma membrane (GO:0007016)2.39701527
102macrophage activation involved in immune response (GO:0002281)2.38482237
103semaphorin-plexin signaling pathway (GO:0071526)2.37952076
104multicellular organismal catabolic process (GO:0044243)2.36706043
105chondrocyte proliferation (GO:0035988)2.36615857
106multicellular organismal metabolic process (GO:0044236)2.36464553
107cholesterol efflux (GO:0033344)2.36350195
108reverse cholesterol transport (GO:0043691)2.35064637
109stress fiber assembly (GO:0043149)2.35051223
110positive regulation of glycogen biosynthetic process (GO:0045725)2.34684862
111negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.34601887
112keratan sulfate catabolic process (GO:0042340)2.34005128
113regulation of interferon-beta biosynthetic process (GO:0045357)2.32274744
114dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.32145468
115regulation of extracellular matrix organization (GO:1903053)2.31479224
116focal adhesion assembly (GO:0048041)2.31374070
117cell-substrate adherens junction assembly (GO:0007045)2.31374070
118regulation of early endosome to late endosome transport (GO:2000641)2.31232259
119regulation of macrophage chemotaxis (GO:0010758)2.31205513
120positive regulation of coagulation (GO:0050820)2.30873476
121positive regulation of axon extension (GO:0045773)2.30120717
122positive regulation of blood vessel endothelial cell migration (GO:0043536)2.29883117
123phagocytosis, recognition (GO:0006910)2.28303939
124endothelial cell morphogenesis (GO:0001886)2.26902847
125pinocytosis (GO:0006907)2.26456770
126endothelial cell chemotaxis (GO:0035767)2.26312611
127peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.26231417
128blood vessel maturation (GO:0001955)2.26166502
129glial cell migration (GO:0008347)2.25741902
130fibrinolysis (GO:0042730)2.25277227
131vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.24735549
132high-density lipoprotein particle remodeling (GO:0034375)2.23911305
133cortical actin cytoskeleton organization (GO:0030866)2.23215332
134hyaluronan catabolic process (GO:0030214)2.21673763
135heparan sulfate proteoglycan metabolic process (GO:0030201)2.21319906
136regulation of plasminogen activation (GO:0010755)2.21108886
137response to laminar fluid shear stress (GO:0034616)2.20857377
138positive regulation of fatty acid metabolic process (GO:0045923)2.20716819
139extracellular matrix disassembly (GO:0022617)2.20250749
140negative regulation of lipid transport (GO:0032369)2.19642211
141vascular endothelial growth factor signaling pathway (GO:0038084)2.17576140
142embryonic retina morphogenesis in camera-type eye (GO:0060059)2.17311622
143protein retention in ER lumen (GO:0006621)2.17246452
144regulation of fatty acid oxidation (GO:0046320)2.17189578
145complement activation (GO:0006956)2.17014116
146hypotonic response (GO:0006971)2.16345703
147L-phenylalanine catabolic process (GO:0006559)2.15969120
148erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.15969120
149negative regulation of granulocyte differentiation (GO:0030853)2.15527056
150plasma lipoprotein particle assembly (GO:0034377)2.15303828
151detection of molecule of bacterial origin (GO:0032490)2.15225398
152regulation of axon extension involved in axon guidance (GO:0048841)2.15210507
153mesenchymal-epithelial cell signaling (GO:0060638)2.14980024
154cell proliferation involved in metanephros development (GO:0072203)2.14877963
155glycosaminoglycan catabolic process (GO:0006027)2.13836421
156epithelial cell-cell adhesion (GO:0090136)2.13480171
157bile acid biosynthetic process (GO:0006699)2.13372354
158bone trabecula formation (GO:0060346)2.11907022
159embryo implantation (GO:0007566)2.11594719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.63645131
2* RXR_22158963_ChIP-Seq_LIVER_Mouse2.89112268
3* LXR_22158963_ChIP-Seq_LIVER_Mouse2.66610860
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58807443
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.44388856
6* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.39547503
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.28808768
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.23535168
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19619662
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.13951213
11* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.00457661
12* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.87106501
13SMAD_19615063_ChIP-ChIP_OVARY_Human1.83435545
14CLOCK_20551151_ChIP-Seq_293T_Human1.82864091
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78573594
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77929254
17DROSHA_22980978_ChIP-Seq_HELA_Human1.72960065
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72234333
19* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67185343
20KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67004478
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.66309469
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63490367
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60078777
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59241705
25* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52933442
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52821152
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.51480458
28* FOXA2_19822575_ChIP-Seq_HepG2_Human1.46014257
29LXR_22292898_ChIP-Seq_THP-1_Human1.44686497
30* KDM2B_26808549_Chip-Seq_K562_Human1.41484323
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40604404
32* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39997834
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39908529
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39859718
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.38693328
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.38534850
37TP53_16413492_ChIP-PET_HCT116_Human1.38425484
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.36275634
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.34472713
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34386035
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34258740
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34258740
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.34227618
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33078216
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32949205
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31783507
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.31428514
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.30806342
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30354108
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27724404
51KDM2B_26808549_Chip-Seq_DND41_Human1.27355373
52CJUN_26792858_Chip-Seq_BT549_Human1.25406616
53SPI1_23127762_ChIP-Seq_K562_Human1.22700112
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22252719
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22051809
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20973842
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20005886
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.19418033
59* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19328106
60SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19126956
61* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18391781
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18291681
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15656400
64VDR_24787735_ChIP-Seq_THP-1_Human1.14911820
65NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14271224
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13651078
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13292511
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.12588229
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12423804
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.12062930
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.11908459
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09690608
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09520982
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09037637
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09037637
76* TP53_23651856_ChIP-Seq_MEFs_Mouse1.08903193
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07899813
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07796423
79AHR_22903824_ChIP-Seq_MCF-7_Human1.07041580
80IRF8_21731497_ChIP-ChIP_J774_Mouse1.07006440
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06763437
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05516251
83* KDM2B_26808549_Chip-Seq_JURKAT_Human1.05089330
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.04105120
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.04105120
86* TP53_22127205_ChIP-Seq_IMR90_Human1.03904245
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03018321
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02903629
89BRD4_25478319_ChIP-Seq_HGPS_Human1.01217443
90TCF7_22412390_ChIP-Seq_EML_Mouse1.00235455
91* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.00153537
92RXR_22108803_ChIP-Seq_LS180_Human0.99733983
93* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99669080
94STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98349880
95IRF8_22096565_ChIP-ChIP_GC-B_Human0.97839282
96UBF1/2_26484160_Chip-Seq_HMECs_Human0.96832875
97GATA1_19941826_ChIP-Seq_K562_Human0.96804725
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96799017
99* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96258685
100ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95271216
101RACK7_27058665_Chip-Seq_MCF-7_Human0.94432722
102EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93986329
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93663877
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93660133
105TP53_20018659_ChIP-ChIP_R1E_Mouse0.93524015
106ERG_21242973_ChIP-ChIP_JURKAT_Human0.92857426
107PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92658321
108* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92539590
109* SA1_22415368_ChIP-Seq_MEFs_Mouse0.92172475
110SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.91187300
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.90994397
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90883566
113SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90737969
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89689910
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89482397
116SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88996430
117ISL1_27105846_Chip-Seq_CPCs_Mouse0.88804278
118GATA2_19941826_ChIP-Seq_K562_Human0.88679693
119SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87918600
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87217063
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85291240

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.70826473
2MP0000569_abnormal_digit_pigmentation4.54152307
3MP0003705_abnormal_hypodermis_morpholog4.49377962
4MP0005275_abnormal_skin_tensile3.46339576
5MP0001958_emphysema3.01796566
6MP0003279_aneurysm2.83577878
7MP0005503_abnormal_tendon_morphology2.76269399
8MP0005058_abnormal_lysosome_morphology2.72825663
9MP0003172_abnormal_lysosome_physiology2.57329474
10MP0009840_abnormal_foam_cell2.55821167
11MP0005360_urolithiasis2.52336019
12MP0002139_abnormal_hepatobiliary_system2.51806529
13MP0005257_abnormal_intraocular_pressure2.46154946
14MP0003252_abnormal_bile_duct2.10033650
15MP0003191_abnormal_cellular_cholesterol2.07218723
16MP0003300_gastrointestinal_ulcer1.98222856
17MP0005365_abnormal_bile_salt1.96841859
18MP0001542_abnormal_bone_strength1.95811097
19MP0003566_abnormal_cell_adhesion1.86387982
20MP0003091_abnormal_cell_migration1.83611614
21MP0010329_abnormal_lipoprotein_level1.76467735
22MP0003045_fibrosis1.73046217
23MP0005076_abnormal_cell_differentiation1.67422358
24MP0005023_abnormal_wound_healing1.65048170
25MP0000604_amyloidosis1.61769089
26MP0005670_abnormal_white_adipose1.61112670
27MP0002060_abnormal_skin_morphology1.56476747
28MP0003690_abnormal_glial_cell1.55970057
29MP0004510_myositis1.52881477
30MP0005085_abnormal_gallbladder_physiolo1.49912943
31MP0004272_abnormal_basement_membrane1.47427701
32MP0002168_other_aberrant_phenotype1.47033490
33MP0009384_cardiac_valve_regurgitation1.45094970
34MP0003303_peritoneal_inflammation1.38849019
35MP0004130_abnormal_muscle_cell1.37743918
36MP0005623_abnormal_meninges_morphology1.37273913
37MP0003283_abnormal_digestive_organ1.37048330
38MP0002295_abnormal_pulmonary_circulatio1.31268624
39MP0005083_abnormal_biliary_tract1.27821053
40MP0009278_abnormal_bone_marrow1.25612380
41MP0002108_abnormal_muscle_morphology1.23852314
42MP0002998_abnormal_bone_remodeling1.22094785
43MP0000751_myopathy1.21942621
44MP0003075_altered_response_to1.21664359
45MP0005409_darkened_coat_color1.20303794
46MP0000767_abnormal_smooth_muscle1.17369420
47MP0005508_abnormal_skeleton_morphology1.16626171
48MP0004858_abnormal_nervous_system1.16250964
49MP0004859_abnormal_synaptic_plasticity1.15186956
50MP0001243_abnormal_dermal_layer1.11836668
51MP0009780_abnormal_chondrocyte_physiolo1.11788627
52MP0008875_abnormal_xenobiotic_pharmacok1.11683248
53MP0000733_abnormal_muscle_development1.10932904
54MP0002896_abnormal_bone_mineralization1.09485052
55MP0003828_pulmonary_edema1.09005559
56MP0001533_abnormal_skeleton_physiology1.08388536
57MP0001299_abnormal_eye_distance/1.07610770
58MP0000343_altered_response_to1.00434945
59MP0003950_abnormal_plasma_membrane1.00187834
60MP0000609_abnormal_liver_physiology0.96401811
61* MP0002118_abnormal_lipid_homeostasis0.93521801
62MP0000920_abnormal_myelination0.92880191
63MP0005390_skeleton_phenotype0.92868915
64MP0005375_adipose_tissue_phenotype0.91582447
65MP0005666_abnormal_adipose_tissue0.90178455
66MP0003634_abnormal_glial_cell0.89500254
67MP0000534_abnormal_ureter_morphology0.88515612
68MP0002254_reproductive_system_inflammat0.88004927
69MP0004185_abnormal_adipocyte_glucose0.87247905
70MP0002877_abnormal_melanocyte_morpholog0.85019761
71MP0006082_CNS_inflammation0.84530722
72MP0010386_abnormal_urinary_bladder0.84109683
73MP0005197_abnormal_uvea_morphology0.84037861
74MP0008004_abnormal_stomach_pH0.83922509
75MP0003115_abnormal_respiratory_system0.83041552
76MP0001348_abnormal_lacrimal_gland0.82444489
77MP0001915_intracranial_hemorrhage0.82421304
78MP0002933_joint_inflammation0.81166434
79MP0003436_decreased_susceptibility_to0.81028157
80MP0000371_diluted_coat_color0.81010306
81MP0005464_abnormal_platelet_physiology0.80342837
82MP0000759_abnormal_skeletal_muscle0.79585329
83MP0006138_congestive_heart_failure0.79300950
84MP0003329_amyloid_beta_deposits0.78051738
85MP0002971_abnormal_brown_adipose0.77458086
86MP0001614_abnormal_blood_vessel0.75779654
87MP0000428_abnormal_craniofacial_morphol0.75482563
88MP0002089_abnormal_postnatal_growth/wei0.75344767
89MP0000003_abnormal_adipose_tissue0.75169235
90MP0004947_skin_inflammation0.74418020
91MP0003879_abnormal_hair_cell0.74237744
92MP0000249_abnormal_blood_vessel0.74133770
93MP0000858_altered_metastatic_potential0.72945782
94MP0010368_abnormal_lymphatic_system0.72624242
95MP0000013_abnormal_adipose_tissue0.72599159
96MP0000163_abnormal_cartilage_morphology0.72120636
97MP0003795_abnormal_bone_structure0.71731570
98MP0008961_abnormal_basal_metabolism0.71636842
99MP0002090_abnormal_vision0.71460105
100MP0010352_gastrointestinal_tract_polyps0.71218329
101MP0000747_muscle_weakness0.70402644
102MP0005165_increased_susceptibility_to0.69642013
103MP0001849_ear_inflammation0.69582677
104MP0002113_abnormal_skeleton_development0.68776923
105MP0005171_absent_coat_pigmentation0.68549831
106MP0006054_spinal_hemorrhage0.68124060
107MP0002115_abnormal_skeleton_extremities0.68049914
108MP0009250_abnormal_appendicular_skeleto0.67562530
109MP0002419_abnormal_innate_immunity0.67280489
110MP0003448_altered_tumor_morphology0.66936396
111MP0010307_abnormal_tumor_latency0.66589876
112MP0001177_atelectasis0.66397283
113MP0008260_abnormal_autophagy0.66236814
114MP0009115_abnormal_fat_cell0.66108796
115MP0003385_abnormal_body_wall0.65376287
116MP0002928_abnormal_bile_duct0.63941408
117MP0003453_abnormal_keratinocyte_physiol0.63717668
118* MP0002128_abnormal_blood_circulation0.63411774
119MP0003941_abnormal_skin_development0.63393291
120MP0005164_abnormal_response_to0.62593902
121MP0004087_abnormal_muscle_fiber0.61021227
122MP0002133_abnormal_respiratory_system0.61014396
123MP0005388_respiratory_system_phenotype0.61014396
124MP0005167_abnormal_blood-brain_barrier0.60994963
125MP0004883_abnormal_blood_vessel0.60764307
126MP0005595_abnormal_vascular_smooth0.59847732
127MP0005334_abnormal_fat_pad0.57698672
128MP0003195_calcinosis0.57613441
129MP0005332_abnormal_amino_acid0.57043985
130MP0005319_abnormal_enzyme/_coenzyme0.56065326

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.51655278
2Premature rupture of membranes (HP:0001788)4.98602980
3Cerebral aneurysm (HP:0004944)4.49183074
4Shallow orbits (HP:0000586)4.27500006
5Broad metatarsal (HP:0001783)4.16917603
6Ankle contracture (HP:0006466)3.73337470
7Peritonitis (HP:0002586)3.60252080
8Aortic dissection (HP:0002647)3.44102756
9Deep venous thrombosis (HP:0002625)3.29012813
10Mitral valve prolapse (HP:0001634)3.25269136
11Complement deficiency (HP:0004431)3.24155203
12Cervical subluxation (HP:0003308)3.21916320
13Aortic aneurysm (HP:0004942)3.06794699
14Systemic lupus erythematosus (HP:0002725)3.02311205
15Dilatation of the ascending aorta (HP:0005111)2.86758040
16Turricephaly (HP:0000262)2.85453049
17Bladder diverticulum (HP:0000015)2.83568419
18Myocardial infarction (HP:0001658)2.79870077
19Genu recurvatum (HP:0002816)2.76328858
20Abnormality of dentin (HP:0010299)2.74034254
21Mitral stenosis (HP:0001718)2.71240942
22Atrophic scars (HP:0001075)2.71097120
23Abnormality of complement system (HP:0005339)2.68238413
24Fragile skin (HP:0001030)2.67436670
25Increased connective tissue (HP:0009025)2.66502913
26Wrist flexion contracture (HP:0001239)2.57369304
27Mitral regurgitation (HP:0001653)2.57198384
28Striae distensae (HP:0001065)2.56238484
29Vertebral compression fractures (HP:0002953)2.54648875
30Xanthomatosis (HP:0000991)2.54564866
31Soft skin (HP:0000977)2.54143143
32Abnormality of skeletal muscle fiber size (HP:0012084)2.53719376
33Aortic regurgitation (HP:0001659)2.49203746
34Distal upper limb amyotrophy (HP:0007149)2.49053857
35Upper limb amyotrophy (HP:0009129)2.49053857
36Aneurysm (HP:0002617)2.46221288
37Blue sclerae (HP:0000592)2.42236867
38Mildly elevated creatine phosphokinase (HP:0008180)2.39607258
39Obstructive sleep apnea (HP:0002870)2.39546009
40Increased cerebral lipofuscin (HP:0011813)2.39233045
41Dysostosis multiplex (HP:0000943)2.37415852
42Vascular tortuosity (HP:0004948)2.32913698
43Osteolytic defects of the hand bones (HP:0009699)2.30835430
44Osteolytic defects of the phalanges of the hand (HP:0009771)2.30835430
45Joint stiffness (HP:0001387)2.29499399
46Spondylolisthesis (HP:0003302)2.27198992
47Disproportionate tall stature (HP:0001519)2.26218316
48Biconcave vertebral bodies (HP:0004586)2.24788823
49Arterial tortuosity (HP:0005116)2.22985783
50Skin nodule (HP:0200036)2.22260850
51Long toe (HP:0010511)2.21747936
52Abnormality of polysaccharide metabolism (HP:0011012)2.20110967
53Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20110967
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20110967
55Ulnar bowing (HP:0003031)2.19288015
56Mucopolysacchariduria (HP:0008155)2.16813228
57Urinary glycosaminoglycan excretion (HP:0003541)2.16813228
58Neurofibrillary tangles (HP:0002185)2.15230421
59Glomerulonephritis (HP:0000099)2.13826634
60Absent frontal sinuses (HP:0002688)2.12505623
61Alopecia of scalp (HP:0002293)2.12422004
62Hand muscle atrophy (HP:0009130)2.11009829
63Hypoalphalipoproteinemia (HP:0003233)2.09427120
64Mild short stature (HP:0003502)2.09102775
65Bowel diverticulosis (HP:0005222)2.07733716
66Type 1 muscle fiber predominance (HP:0003803)2.06746162
67Slender build (HP:0001533)2.04811197
68Aortic valve stenosis (HP:0001650)2.04419847
69Hypoventilation (HP:0002791)2.03901855
70Wormian bones (HP:0002645)2.03253241
71Follicular hyperkeratosis (HP:0007502)2.02198572
72Hyperextensible skin (HP:0000974)2.02089302
73Nephritis (HP:0000123)2.01837848
74Urethral obstruction (HP:0000796)2.01167714
75Ectopia lentis (HP:0001083)2.00708120
76Axonal loss (HP:0003447)2.00014444
77Camptodactyly of toe (HP:0001836)1.98549686
78Abnormality of the Achilles tendon (HP:0005109)1.93222288
79Amyloidosis (HP:0011034)1.93047577
80Ovoid vertebral bodies (HP:0003300)1.92717529
81Hyperacusis (HP:0010780)1.91987910
82Joint hemorrhage (HP:0005261)1.91416470
83Hypoplasia of the iris (HP:0007676)1.91235533
84Overgrowth (HP:0001548)1.90948018
85Global brain atrophy (HP:0002283)1.88843582
86Elbow flexion contracture (HP:0002987)1.87819049
87Round ear (HP:0100830)1.85603695
88Achilles tendon contracture (HP:0001771)1.83333312
89Thin bony cortex (HP:0002753)1.82787170
90Spinal rigidity (HP:0003306)1.81492032
91Distal lower limb amyotrophy (HP:0008944)1.81002144
92Abnormality of the acetabulum (HP:0003170)1.78451961
93Flared iliac wings (HP:0002869)1.78238996
94Joint laxity (HP:0001388)1.77874336
95Syringomyelia (HP:0003396)1.77677452
96Spinal cord lesions (HP:0100561)1.77677452
97Narrow palate (HP:0000189)1.77545410
98Natal tooth (HP:0000695)1.77499708
99Flat cornea (HP:0007720)1.77190063
100Infantile muscular hypotonia (HP:0008947)1.77143422
101Osteoarthritis (HP:0002758)1.76696248
102Deviation of the hallux (HP:0010051)1.76528248
103Hyperlipoproteinemia (HP:0010980)1.76280892
104Cerebral inclusion bodies (HP:0100314)1.75210852
105Increased variability in muscle fiber diameter (HP:0003557)1.75093492
106Recurrent gram-negative bacterial infections (HP:0005420)1.74604819
107Asymmetric septal hypertrophy (HP:0001670)1.74355173
108Hypercholesterolemia (HP:0003124)1.73668124
109Lower limb amyotrophy (HP:0007210)1.73606649
110Wide anterior fontanel (HP:0000260)1.73094220
111Abnormality of the common coagulation pathway (HP:0010990)1.72696776
112Pulmonary artery stenosis (HP:0004415)1.72675160
113Lymphangioma (HP:0100764)1.72225975
114Neonatal short-limb short stature (HP:0008921)1.71746162
115Enlarged penis (HP:0000040)1.71687995
116Nuclear cataract (HP:0100018)1.70982042
117Broad ribs (HP:0000885)1.69967397
118Abnormal delivery (HP:0001787)1.69080826
119Abnormality of liposaccharide metabolism (HP:0010968)1.69006208
120Abnormality of glycosphingolipid metabolism (HP:0004343)1.69006208
121Abnormality of glycolipid metabolism (HP:0010969)1.69006208
122Generalized amyotrophy (HP:0003700)1.68167760
123Short nail (HP:0001799)1.68144891
124Coxa vara (HP:0002812)1.67845265
125Venous abnormality (HP:0002624)1.64831433
126Inguinal hernia (HP:0000023)1.63912108

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.87315300
2TTN3.29528067
3CAMK1D3.06262461
4RIPK13.00970381
5SIK12.99065462
6ERN12.90292613
7CAMK1G2.72816792
8DDR22.71750757
9PKN22.56277232
10PDGFRA2.55853120
11MYLK2.43524771
12DAPK22.02222685
13PRPF4B2.00440771
14TGFBR21.92964170
15PTK61.83603836
16SIK21.69618614
17BMX1.56503132
18CAMKK11.52695689
19KIT1.50733449
20LATS11.48694973
21JAK11.37517589
22PRKCH1.36129284
23ICK1.34551205
24MAP3K61.33466873
25LATS21.32556460
26NTRK11.23366783
27PTK21.20092949
28PDGFRB1.19876519
29PAK61.16432525
30AKT31.12961428
31MTOR1.12858388
32TESK11.11962357
33EPHB11.08947908
34BLK1.08564348
35FGFR41.08144571
36TAOK31.06928249
37PAK21.06791235
38STK381.02979639
39MAP3K91.02045295
40CDK121.00906343
41CSF1R0.99833201
42MAP3K100.99034418
43TYK20.98410830
44MAP3K30.97274233
45RET0.88736068
46CAMKK20.87858867
47RIPK40.86452226
48SGK30.86450316
49PAK40.85477982
50HCK0.82862444
51PRKD30.82625932
52MAP3K130.81635781
53MAP3K70.80609884
54TBK10.80412524
55SCYL20.80358568
56PTK2B0.79804830
57DMPK0.78526425
58KSR20.78104497
59MARK10.77812218
60MOS0.77550115
61ZAP700.77026579
62MST1R0.76080167
63SMG10.76052711
64FES0.73666007
65CDK60.73515984
66PIK3CG0.73389240
67EEF2K0.72236845
68WNK10.72210823
69FGFR20.71654943
70RPS6KC10.71261718
71RPS6KL10.71261718
72IRAK30.71195411
73TAOK10.70081218
74ROCK20.69597617
75TAOK20.67790091
76CAMK40.67772525
77ERBB20.67533872
78ABL20.66917770
79LIMK10.66664091
80NEK90.65461061
81JAK20.65354500
82RPS6KA20.64615407
83GRK70.64239206
84TRPM70.64215208
85JAK30.63197278
86FGFR10.62949374
87PDPK10.61940700
88EPHB20.61085888
89FGR0.60567138
90MAP2K40.60404130
91LMTK20.58657379
92CSK0.58477043
93MARK20.58154186
94FER0.57829858
95MAPK120.57602864
96MAP2K30.56487337
97EPHA30.56322939
98ROCK10.54215919
99MAP3K10.54067683
100MAPK40.53590514
101FGFR30.53443300
102FYN0.53108798
103PRKG20.52988041
104MET0.52940727
105GSK3A0.52482362
106RPS6KA60.50713120
107PRKD10.50047949
108DYRK1B0.49947861
109SGK4940.49603412
110SGK2230.49603412
111TYRO30.49061053
112EGFR0.48700024
113* SRC0.47273657
114MAPK70.46232181
115PRKD20.45964474
116PRKAA20.45821506
117HIPK20.45434260
118INSR0.44897331
119STK30.44859488
120DAPK30.44817522
121CAMK10.44602584
122ERBB40.43474720
123PAK30.42496746
124NTRK20.42337475
125MAP3K20.41106245
126PDK10.41101020
127GRK50.39820194
128CAMK2G0.39263101
129MAP2K10.39248568
130SGK20.38927747
131ARAF0.38766941
132INSRR0.38393923
133CDC42BPA0.38193648

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.49427924
2Staphylococcus aureus infection_Homo sapiens_hsa051502.66299734
3Complement and coagulation cascades_Homo sapiens_hsa046102.49361073
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.33567971
5Caffeine metabolism_Homo sapiens_hsa002322.29503318
6Glycosaminoglycan degradation_Homo sapiens_hsa005311.85009848
7Arginine biosynthesis_Homo sapiens_hsa002201.80121288
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65430054
9PPAR signaling pathway_Homo sapiens_hsa033201.57416536
10ECM-receptor interaction_Homo sapiens_hsa045121.52825720
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51309353
12Bile secretion_Homo sapiens_hsa049761.46596714
13Lysosome_Homo sapiens_hsa041421.44496660
14Lysine degradation_Homo sapiens_hsa003101.31250323
15Amoebiasis_Homo sapiens_hsa051461.25266442
16Focal adhesion_Homo sapiens_hsa045101.23366825
17Fatty acid degradation_Homo sapiens_hsa000711.20379665
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19839426
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17381444
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13638131
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08123990
22Type II diabetes mellitus_Homo sapiens_hsa049301.07367599
23Proteoglycans in cancer_Homo sapiens_hsa052051.05318282
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04603901
25Fatty acid metabolism_Homo sapiens_hsa012121.02773641
26Other glycan degradation_Homo sapiens_hsa005111.02709009
27Tryptophan metabolism_Homo sapiens_hsa003801.00559163
28ABC transporters_Homo sapiens_hsa020100.96306083
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95388997
30Insulin resistance_Homo sapiens_hsa049310.92236686
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90862916
32Adipocytokine signaling pathway_Homo sapiens_hsa049200.89574911
33Prion diseases_Homo sapiens_hsa050200.87769883
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87692805
35Glioma_Homo sapiens_hsa052140.87523576
36PI3K-Akt signaling pathway_Homo sapiens_hsa041510.86934963
37Osteoclast differentiation_Homo sapiens_hsa043800.86040079
38Gap junction_Homo sapiens_hsa045400.84498845
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84417703
40Chronic myeloid leukemia_Homo sapiens_hsa052200.83546870
41Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81858180
42Starch and sucrose metabolism_Homo sapiens_hsa005000.81105955
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.79981623
44Renal cell carcinoma_Homo sapiens_hsa052110.79279726
45Dilated cardiomyopathy_Homo sapiens_hsa054140.78144845
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75384491
47Axon guidance_Homo sapiens_hsa043600.75025164
48Acute myeloid leukemia_Homo sapiens_hsa052210.74654966
49Melanogenesis_Homo sapiens_hsa049160.74307977
50VEGF signaling pathway_Homo sapiens_hsa043700.73068118
51Protein digestion and absorption_Homo sapiens_hsa049740.72679936
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71889270
53Fatty acid biosynthesis_Homo sapiens_hsa000610.71632615
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71304905
55mTOR signaling pathway_Homo sapiens_hsa041500.70571029
56Long-term potentiation_Homo sapiens_hsa047200.68458811
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67519606
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67130492
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67122936
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66272197
61Endometrial cancer_Homo sapiens_hsa052130.66189749
62Butanoate metabolism_Homo sapiens_hsa006500.66188020
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65922100
64Phagosome_Homo sapiens_hsa041450.65445545
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65436995
66Platelet activation_Homo sapiens_hsa046110.65113009
67Salmonella infection_Homo sapiens_hsa051320.64918952
68Pathways in cancer_Homo sapiens_hsa052000.64879143
69Tuberculosis_Homo sapiens_hsa051520.64810670
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.64631476
71Pertussis_Homo sapiens_hsa051330.63804749
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.63390013
73* Malaria_Homo sapiens_hsa051440.63314690
74Prolactin signaling pathway_Homo sapiens_hsa049170.63229360
75Adherens junction_Homo sapiens_hsa045200.62851904
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62849147
77Choline metabolism in cancer_Homo sapiens_hsa052310.62690265
78Estrogen signaling pathway_Homo sapiens_hsa049150.61838884
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61429054
80Bladder cancer_Homo sapiens_hsa052190.59261063
81Insulin signaling pathway_Homo sapiens_hsa049100.58685099
82GnRH signaling pathway_Homo sapiens_hsa049120.58658682
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58090258
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.58001013
85Prostate cancer_Homo sapiens_hsa052150.57939148
86Melanoma_Homo sapiens_hsa052180.57665409
87Renin-angiotensin system_Homo sapiens_hsa046140.56682014
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56533746
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56285542
90Thyroid hormone synthesis_Homo sapiens_hsa049180.56069860
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55993568
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55260529
93ErbB signaling pathway_Homo sapiens_hsa040120.55235897
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.55131158
95Vibrio cholerae infection_Homo sapiens_hsa051100.55078144
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54480400
97Oxytocin signaling pathway_Homo sapiens_hsa049210.54251087
98Leishmaniasis_Homo sapiens_hsa051400.53323088
99Ras signaling pathway_Homo sapiens_hsa040140.53026972
100AMPK signaling pathway_Homo sapiens_hsa041520.53010576
101Pancreatic cancer_Homo sapiens_hsa052120.52939106
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52419183
103Dorso-ventral axis formation_Homo sapiens_hsa043200.51832943
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51484040
105Rap1 signaling pathway_Homo sapiens_hsa040150.51420501
106MAPK signaling pathway_Homo sapiens_hsa040100.50770018
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50717117
108Small cell lung cancer_Homo sapiens_hsa052220.48683517
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48588570
110Fat digestion and absorption_Homo sapiens_hsa049750.48354550
111Chemical carcinogenesis_Homo sapiens_hsa052040.47867141
112Toxoplasmosis_Homo sapiens_hsa051450.47863077
113Glycerolipid metabolism_Homo sapiens_hsa005610.47595279
114beta-Alanine metabolism_Homo sapiens_hsa004100.47012904
115Galactose metabolism_Homo sapiens_hsa000520.46736066
116TNF signaling pathway_Homo sapiens_hsa046680.46720373
117HIF-1 signaling pathway_Homo sapiens_hsa040660.46308630
118Salivary secretion_Homo sapiens_hsa049700.46180996
119Peroxisome_Homo sapiens_hsa041460.45221544
120cAMP signaling pathway_Homo sapiens_hsa040240.44975067
121MicroRNAs in cancer_Homo sapiens_hsa052060.43928437
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43312886
123Endocytosis_Homo sapiens_hsa041440.42594247
124B cell receptor signaling pathway_Homo sapiens_hsa046620.42143585
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.41785317
126Non-small cell lung cancer_Homo sapiens_hsa052230.41310789
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40720821
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.40597840
129Glucagon signaling pathway_Homo sapiens_hsa049220.40421368
130Gastric acid secretion_Homo sapiens_hsa049710.38989995
131Notch signaling pathway_Homo sapiens_hsa043300.37882436
132Renin secretion_Homo sapiens_hsa049240.37833185

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