LRP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.50797341
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.50797341
3antigen processing and presentation of endogenous antigen (GO:0019883)5.82930692
4positive regulation of gamma-delta T cell activation (GO:0046645)4.54364674
5negative regulation of cell killing (GO:0031342)4.22615538
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.22615538
7regulation of gamma-delta T cell differentiation (GO:0045586)4.21843258
8positive thymic T cell selection (GO:0045059)3.89956195
9regulation of gamma-delta T cell activation (GO:0046643)3.79858844
10detection of other organism (GO:0098543)3.66931718
11detection of bacterium (GO:0016045)3.57206433
12regulation of interleukin-12 biosynthetic process (GO:0045075)3.53078868
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.47478918
14antigen processing and presentation via MHC class Ib (GO:0002475)3.39229137
15positive regulation of histone deacetylation (GO:0031065)3.39196737
16JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.38999889
17macrophage activation involved in immune response (GO:0002281)3.35678690
18detection of external biotic stimulus (GO:0098581)3.28641189
19response to peptidoglycan (GO:0032494)3.25601433
20Arp2/3 complex-mediated actin nucleation (GO:0034314)3.24245356
21negative regulation of erythrocyte differentiation (GO:0045647)3.22444783
22neutrophil activation involved in immune response (GO:0002283)3.21796887
23detection of molecule of bacterial origin (GO:0032490)3.18471898
24protein localization to endosome (GO:0036010)3.13480754
25positive regulation of Cdc42 GTPase activity (GO:0043089)3.11977411
26thymic T cell selection (GO:0045061)3.10307740
27leukocyte aggregation (GO:0070486)3.08938057
28COPI coating of Golgi vesicle (GO:0048205)3.07795794
29Golgi transport vesicle coating (GO:0048200)3.07795794
30tolerance induction (GO:0002507)3.03412151
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01590365
32positive regulation of natural killer cell differentiation (GO:0032825)3.00159981
33response to laminar fluid shear stress (GO:0034616)2.93833856
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.81705409
35response to host (GO:0075136)2.81705409
36response to host defenses (GO:0052200)2.81705409
37negative thymic T cell selection (GO:0045060)2.80875611
38regulation of T-helper 2 cell differentiation (GO:0045628)2.80153143
39positive regulation of lamellipodium assembly (GO:0010592)2.79240142
40negative T cell selection (GO:0043383)2.76942954
41detection of biotic stimulus (GO:0009595)2.75683705
42cellular extravasation (GO:0045123)2.75264924
43positive T cell selection (GO:0043368)2.75049755
44response to interleukin-15 (GO:0070672)2.74098965
45hepatocyte apoptotic process (GO:0097284)2.73684204
46response to host immune response (GO:0052572)2.70701483
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.70701483
48regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70556501
49barbed-end actin filament capping (GO:0051016)2.69855863
50regulation of T cell tolerance induction (GO:0002664)2.67590743
51natural killer cell differentiation (GO:0001779)2.66363514
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.66344426
53leukocyte cell-cell adhesion (GO:0007159)2.66311847
54germinal center formation (GO:0002467)2.65341165
55apoptotic cell clearance (GO:0043277)2.64090559
56negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.63255121
57morphogenesis of an endothelium (GO:0003159)2.62974464
58endothelial tube morphogenesis (GO:0061154)2.62974464
59T cell selection (GO:0045058)2.61638265
60positive regulation of protein deacetylation (GO:0090312)2.61613039
61regulation of leukocyte degranulation (GO:0043300)2.61158204
62stress fiber assembly (GO:0043149)2.59057634
63regulation of dendritic cell antigen processing and presentation (GO:0002604)2.58595332
64growth hormone receptor signaling pathway (GO:0060396)2.58291740
65response to type I interferon (GO:0034340)2.57003304
66positive regulation of lamellipodium organization (GO:1902745)2.55817052
67negative regulation of lymphocyte mediated immunity (GO:0002707)2.55791526
68lipopolysaccharide-mediated signaling pathway (GO:0031663)2.55160262
69hypotonic response (GO:0006971)2.54391347
70pentose-phosphate shunt (GO:0006098)2.54166120
71positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.52726598
72regulation of interferon-beta biosynthetic process (GO:0045357)2.52661049
73neutrophil activation (GO:0042119)2.52651050
74positive regulation of tolerance induction (GO:0002645)2.52531155
75regulation of mast cell degranulation (GO:0043304)2.51859327
76positive regulation of receptor recycling (GO:0001921)2.51835291
77regulation of B cell receptor signaling pathway (GO:0050855)2.51278459
78NIK/NF-kappaB signaling (GO:0038061)2.50413068
79response to muramyl dipeptide (GO:0032495)2.49350930
80negative regulation of leukocyte mediated immunity (GO:0002704)2.48962744
81negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.47503882
82positive regulation of B cell differentiation (GO:0045579)2.47410078
83type I interferon signaling pathway (GO:0060337)2.47291501
84cellular response to type I interferon (GO:0071357)2.47291501
85regulation of B cell differentiation (GO:0045577)2.47231040
86regulation of myeloid leukocyte mediated immunity (GO:0002886)2.46935333
87regulation of response to interferon-gamma (GO:0060330)2.46323558
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.45813632
89negative regulation of type 2 immune response (GO:0002829)2.45663830
90positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.45537906
91granulocyte activation (GO:0036230)2.44378796
92skin morphogenesis (GO:0043589)2.43047568
93leukocyte migration involved in inflammatory response (GO:0002523)2.42290674
94valine metabolic process (GO:0006573)2.40903670
95regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.37913871
96T cell apoptotic process (GO:0070231)2.37668558
97regulation of extracellular matrix disassembly (GO:0010715)2.37118204
98production of molecular mediator involved in inflammatory response (GO:0002532)2.36821560
99modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.36106702
100positive regulation by organism of defense response of other organism involved in symbiotic interact2.36106702
101modulation by symbiont of host immune response (GO:0052553)2.36106702
102positive regulation by symbiont of host defense response (GO:0052509)2.36106702
103modulation by symbiont of host defense response (GO:0052031)2.36106702
104modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.36106702
105positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.35565051
106mannose metabolic process (GO:0006013)2.35259518
107negative regulation of interleukin-12 production (GO:0032695)2.34652153
108regulation of cholesterol homeostasis (GO:2000188)2.34236239
109actin nucleation (GO:0045010)2.34101779
110regulation of cholesterol storage (GO:0010885)2.33383096
111establishment of endothelial barrier (GO:0061028)2.33116502
112negative regulation of phagocytosis (GO:0050765)2.33058457
113maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.31204677
114regulation of natural killer cell differentiation (GO:0032823)2.30871998
115regulation of macrophage cytokine production (GO:0010935)2.30341157
116regulation of necroptotic process (GO:0060544)2.29582362
117negative regulation of interleukin-6 production (GO:0032715)2.29499201
118T cell migration (GO:0072678)2.29199233
119activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.29137092
120respiratory burst (GO:0045730)2.28692444
121B cell receptor signaling pathway (GO:0050853)2.28162866
122macrophage activation (GO:0042116)2.27929435
123T cell costimulation (GO:0031295)2.27688016
124immunoglobulin mediated immune response (GO:0016064)2.27339873
125lymphocyte apoptotic process (GO:0070227)2.26875815
126regulation of type 2 immune response (GO:0002828)2.26853974
127low-density lipoprotein particle clearance (GO:0034383)2.25666452
128cellular response to growth hormone stimulus (GO:0071378)2.25140944
129positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.24967874
130positive regulation of blood vessel endothelial cell migration (GO:0043536)2.24437886
131response to interferon-alpha (GO:0035455)2.24028939
132membrane protein intracellular domain proteolysis (GO:0031293)2.23699905
133maternal placenta development (GO:0001893)2.23503401
134regulation of mast cell activation involved in immune response (GO:0033006)2.23005554
135positive regulation of nuclease activity (GO:0032075)2.22920091
136negative regulation of toll-like receptor signaling pathway (GO:0034122)2.22878733
137lymphocyte costimulation (GO:0031294)2.22190830
138interferon-gamma-mediated signaling pathway (GO:0060333)2.21784735
139pinocytosis (GO:0006907)2.21631550
140positive regulation of cellular amide metabolic process (GO:0034250)2.21559429
141negative regulation of stress fiber assembly (GO:0051497)2.21061481
142regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.20998225
143tricarboxylic acid metabolic process (GO:0072350)2.20966079
144interferon-gamma production (GO:0032609)2.20774027
145hemidesmosome assembly (GO:0031581)2.20723206
146regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.20259440
147protein retention in ER lumen (GO:0006621)2.19996784
148regulation of tolerance induction (GO:0002643)2.19791282
149negative regulation of fatty acid transport (GO:2000192)2.19669796
150modulation by symbiont of host cellular process (GO:0044068)2.19320415
151regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.19184152
152negative regulation of bone resorption (GO:0045779)2.19132765
153regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.18348710
154positive regulation of extracellular matrix organization (GO:1903055)2.18220843
155cell-substrate junction assembly (GO:0007044)2.17864041
156positive regulation of T cell mediated cytotoxicity (GO:0001916)2.17668636
157negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.17566234
158positive regulation of interferon-alpha production (GO:0032727)2.16997206
159angiogenesis involved in wound healing (GO:0060055)2.16965205
160negative regulation of cytokine production involved in immune response (GO:0002719)2.16216630
161negative regulation of glycoprotein biosynthetic process (GO:0010561)2.14670569
162positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.14427059
163regulation of T cell mediated cytotoxicity (GO:0001914)2.14304863
164negative regulation of viral entry into host cell (GO:0046597)2.13954580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.56820139
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.24146732
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.04579104
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02253857
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.85490762
6MYC_22102868_ChIP-Seq_BL_Human2.81906353
7VDR_21846776_ChIP-Seq_THP-1_Human2.50647277
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.44346745
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.39201737
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26073543
11MAF_26560356_Chip-Seq_TH1_Human2.17586339
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.14625545
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08555519
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.07374944
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05565952
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01212961
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.99564504
18* TCF7_22412390_ChIP-Seq_EML_Mouse1.97760118
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97614315
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95906731
21UTX_26944678_Chip-Seq_JUKART_Human1.88886347
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.86407962
23VDR_24763502_ChIP-Seq_THP-1_Human1.85088960
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83770403
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.83697731
26CLOCK_20551151_ChIP-Seq_293T_Human1.83620842
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82818346
28MYB_26560356_Chip-Seq_TH2_Human1.82656382
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.81386896
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80889801
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.80563859
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80436446
33LXR_22292898_ChIP-Seq_THP-1_Human1.78589826
34* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77364644
35RUNX_20019798_ChIP-Seq_JUKART_Human1.76735121
36KDM2B_26808549_Chip-Seq_DND41_Human1.75306283
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.74662013
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.72397235
39STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68124557
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65451151
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64347821
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63651133
43* MYB_26560356_Chip-Seq_TH1_Human1.63478741
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.61955959
45SCL_19346495_ChIP-Seq_HPC-7_Human1.59206319
46* RACK7_27058665_Chip-Seq_MCF-7_Human1.58585881
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.58211585
48* RUNX1_22412390_ChIP-Seq_EML_Mouse1.57538626
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56797021
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56583477
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53920457
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53708726
53* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53115479
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53098693
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.50030898
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46411663
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43788096
58* SPI1_23127762_ChIP-Seq_K562_Human1.40811057
59ATF3_27146783_Chip-Seq_COLON_Human1.40294914
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.39796084
61KDM2B_26808549_Chip-Seq_K562_Human1.38509360
62MAF_26560356_Chip-Seq_TH2_Human1.38023635
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35945311
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34095602
65* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30941957
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30276715
67* SPI1_23547873_ChIP-Seq_NB4_Human1.30165625
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.29896989
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.29234223
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27639923
71GATA1_22025678_ChIP-Seq_K562_Human1.26325680
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25559353
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25000103
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.24265411
75* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23285645
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22826770
77* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18996612
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.18433688
79ZNF263_19887448_ChIP-Seq_K562_Human1.18320911
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18274576
81ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18137468
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17160264
83SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16381495
84GATA3_27048872_Chip-Seq_THYMUS_Human1.14976389
85* NCOR1_26117541_ChIP-Seq_K562_Human1.14789434
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.12988980
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12739124
88P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12639871
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11679992
90GATA1_19941826_ChIP-Seq_K562_Human1.10944419
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09767736
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09426987
93* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08804147
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.08776588
95* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08219324
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06600468
97* GATA6_25053715_ChIP-Seq_YYC3_Human1.06211685
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.06090009
99VDR_24787735_ChIP-Seq_THP-1_Human1.04350601
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.03675287
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02987409
102* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02352787
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01813667
104SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01813667
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01715272
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01628560
107* KDM2B_26808549_Chip-Seq_JURKAT_Human1.01283382
108EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00676894
109GATA2_19941826_ChIP-Seq_K562_Human1.00172892
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98338695
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97752975
112PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97706696
113SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97268501
114CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97214004
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96062110
116* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95948507
117RUNX1_27514584_Chip-Seq_MCF-7_Human0.95710842
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.95372428
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95099355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.32622411
2MP0003303_peritoneal_inflammation2.49020944
3MP0003705_abnormal_hypodermis_morpholog2.43354471
4MP0000685_abnormal_immune_system2.41473272
5MP0003436_decreased_susceptibility_to2.22316430
6MP0010234_abnormal_vibrissa_follicle2.18093705
7MP0001835_abnormal_antigen_presentation2.16486048
8MP0005387_immune_system_phenotype2.14219520
9MP0001790_abnormal_immune_system2.14219520
10MP0004947_skin_inflammation2.04489388
11MP0003763_abnormal_thymus_physiology2.02386673
12MP0005451_abnormal_body_composition1.94659621
13MP0008260_abnormal_autophagy1.89348243
14MP0009840_abnormal_foam_cell1.89042120
15MP0001800_abnormal_humoral_immune1.87325579
16MP0010155_abnormal_intestine_physiology1.86907162
17MP0001873_stomach_inflammation1.86150551
18MP0003566_abnormal_cell_adhesion1.86143062
19MP0005058_abnormal_lysosome_morphology1.83422961
20MP0003724_increased_susceptibility_to1.83311046
21MP0010352_gastrointestinal_tract_polyps1.81599951
22MP0005000_abnormal_immune_tolerance1.79530271
23MP0002166_altered_tumor_susceptibility1.79313705
24MP0005671_abnormal_response_to1.77359874
25MP0008438_abnormal_cutaneous_collagen1.74037170
26MP0003866_abnormal_defecation1.73598731
27MP0003191_abnormal_cellular_cholesterol1.73450059
28MP0009785_altered_susceptibility_to1.73291442
29MP0006054_spinal_hemorrhage1.71077635
30MP0002452_abnormal_antigen_presenting1.69437564
31MP0005025_abnormal_response_to1.68713175
32MP0006082_CNS_inflammation1.64188094
33MP0004858_abnormal_nervous_system1.63978520
34MP0002723_abnormal_immune_serum1.60772656
35MP0009333_abnormal_splenocyte_physiolog1.60073138
36MP0002420_abnormal_adaptive_immunity1.57255704
37MP0001819_abnormal_immune_cell1.56570460
38MP0005464_abnormal_platelet_physiology1.54108265
39MP0001958_emphysema1.51409196
40MP0002405_respiratory_system_inflammati1.51384000
41MP0002933_joint_inflammation1.49612395
42MP0003183_abnormal_peptide_metabolism1.49586277
43MP0004510_myositis1.49030534
44MP0002419_abnormal_innate_immunity1.47441125
45MP0001533_abnormal_skeleton_physiology1.43756214
46MP0000465_gastrointestinal_hemorrhage1.42368159
47MP0005023_abnormal_wound_healing1.41557745
48MP0001845_abnormal_inflammatory_respons1.40835109
49MP0002398_abnormal_bone_marrow1.39178570
50MP0005164_abnormal_response_to1.38002078
51MP0004272_abnormal_basement_membrane1.34078407
52MP0000716_abnormal_immune_system1.31116168
53MP0002138_abnormal_hepatobiliary_system1.30607862
54MP0002148_abnormal_hypersensitivity_rea1.30393738
55MP0005390_skeleton_phenotype1.30025195
56MP0009278_abnormal_bone_marrow1.27412464
57MP0003279_aneurysm1.27044014
58MP0003075_altered_response_to1.26444125
59MP0002006_tumorigenesis1.25942632
60MP0009643_abnormal_urine_homeostasis1.25897063
61MP0005275_abnormal_skin_tensile1.24036673
62MP0000767_abnormal_smooth_muscle1.23974915
63MP0000689_abnormal_spleen_morphology1.22508241
64MP0005360_urolithiasis1.21940485
65MP0002722_abnormal_immune_system1.21816738
66MP0002396_abnormal_hematopoietic_system1.21466162
67MP0002877_abnormal_melanocyte_morpholog1.21360048
68MP0004883_abnormal_blood_vessel1.20397313
69MP0000490_abnormal_crypts_of1.19946327
70MP0000858_altered_metastatic_potential1.18487116
71MP0003453_abnormal_keratinocyte_physiol1.16435524
72MP0005409_darkened_coat_color1.14123340
73MP0005503_abnormal_tendon_morphology1.13909551
74MP0005257_abnormal_intraocular_pressure1.13313305
75MP0002429_abnormal_blood_cell1.13169735
76MP0001542_abnormal_bone_strength1.11169681
77MP0008469_abnormal_protein_level1.10207673
78MP0004185_abnormal_adipocyte_glucose1.09085621
79MP0005076_abnormal_cell_differentiation1.08274272
80MP0001853_heart_inflammation1.08005427
81MP0008004_abnormal_stomach_pH1.06469668
82MP0003045_fibrosis1.05459888
83MP0001545_abnormal_hematopoietic_system1.03403852
84MP0005397_hematopoietic_system_phenotyp1.03403852
85MP0002136_abnormal_kidney_physiology1.02465038
86MP0003091_abnormal_cell_migration1.02012283
87MP0004808_abnormal_hematopoietic_stem1.01801931
88MP0002998_abnormal_bone_remodeling1.01204826
89MP0008961_abnormal_basal_metabolism0.99810120
90MP0003172_abnormal_lysosome_physiology0.98860526
91MP0000604_amyloidosis0.98231196
92MP0005310_abnormal_salivary_gland0.97404527
93MP0000343_altered_response_to0.96170901
94MP0000703_abnormal_thymus_morphology0.96007868
95MP0002132_abnormal_respiratory_system0.95872020
96MP0000609_abnormal_liver_physiology0.95659419
97MP0003448_altered_tumor_morphology0.94693164
98MP0001851_eye_inflammation0.93283754
99MP0002060_abnormal_skin_morphology0.93170569
100MP0001666_abnormal_nutrient_absorption0.92922329
101MP0003329_amyloid_beta_deposits0.92285815
102MP0005666_abnormal_adipose_tissue0.88150996
103MP0001849_ear_inflammation0.87546591
104MP0004264_abnormal_extraembryonic_tissu0.87225752
105MP0000477_abnormal_intestine_morphology0.87013315
106MP0000678_abnormal_parathyroid_gland0.86820807
107MP0001663_abnormal_digestive_system0.86198894
108MP0004381_abnormal_hair_follicle0.84710193
109MP0002796_impaired_skin_barrier0.84568752
110MP0001216_abnormal_epidermal_layer0.83734131
111MP0009384_cardiac_valve_regurgitation0.82829689
112MP0010368_abnormal_lymphatic_system0.82594193
113MP0002896_abnormal_bone_mineralization0.81880878
114MP0000249_abnormal_blood_vessel0.80974456
115MP0003795_abnormal_bone_structure0.80605411
116MP0001879_abnormal_lymphatic_vessel0.80521613
117MP0003252_abnormal_bile_duct0.80487961
118MP0005083_abnormal_biliary_tract0.79746486
119MP0005166_decreased_susceptibility_to0.77572767
120MP0003828_pulmonary_edema0.77381926
121MP0005375_adipose_tissue_phenotype0.76069014
122MP0009764_decreased_sensitivity_to0.75699500

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)3.51912014
2Abnormality of the nasal mucosa (HP:0000433)3.42951252
3Eczematoid dermatitis (HP:0000976)3.38743743
4Chronic otitis media (HP:0000389)3.33369271
5Nasal polyposis (HP:0100582)3.31677947
6Elevated erythrocyte sedimentation rate (HP:0003565)3.03830867
7Vascular tortuosity (HP:0004948)2.96989235
8Dysostosis multiplex (HP:0000943)2.88045785
9Cerebral aneurysm (HP:0004944)2.87552251
10Arterial tortuosity (HP:0005116)2.84882248
11Recurrent bronchitis (HP:0002837)2.80596450
12Autoimmune thrombocytopenia (HP:0001973)2.75123203
13IgM deficiency (HP:0002850)2.72506730
14Vacuolated lymphocytes (HP:0001922)2.72280655
15Pustule (HP:0200039)2.66955145
16Recurrent gram-negative bacterial infections (HP:0005420)2.66919006
17Aortic aneurysm (HP:0004942)2.65253077
18Urinary glycosaminoglycan excretion (HP:0003541)2.65141055
19Mucopolysacchariduria (HP:0008155)2.65141055
20Gingivitis (HP:0000230)2.63176386
21Recurrent fungal infections (HP:0002841)2.61021759
22Gastrointestinal infarctions (HP:0005244)2.60599577
23Recurrent viral infections (HP:0004429)2.60485394
24Spontaneous hematomas (HP:0007420)2.59302515
25Increased IgE level (HP:0003212)2.57150463
26Gastrointestinal inflammation (HP:0004386)2.56873151
27Protrusio acetabuli (HP:0003179)2.54999579
28Inflammation of the large intestine (HP:0002037)2.54847013
29Hematochezia (HP:0002573)2.50798672
30Increased connective tissue (HP:0009025)2.45770043
31Colitis (HP:0002583)2.44417728
32Retrobulbar optic neuritis (HP:0100654)2.43935736
33Optic neuritis (HP:0100653)2.43935736
34Cellulitis (HP:0100658)2.43105551
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.39841902
36Abnormality of polysaccharide metabolism (HP:0011012)2.39841902
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.39841902
38Abnormality of glycolipid metabolism (HP:0010969)2.39108742
39Abnormality of liposaccharide metabolism (HP:0010968)2.39108742
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.39108742
41Emphysema (HP:0002097)2.38953979
42Myositis (HP:0100614)2.34758047
43Polycythemia (HP:0001901)2.31498211
44Amyloidosis (HP:0011034)2.31269684
45Aortic dissection (HP:0002647)2.30925166
46Thin bony cortex (HP:0002753)2.29884216
47Spondylolisthesis (HP:0003302)2.29772331
48Cervical subluxation (HP:0003308)2.29307280
49Fragile skin (HP:0001030)2.28292483
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.27850191
51Peritonitis (HP:0002586)2.25746440
52Recurrent abscess formation (HP:0002722)2.22973940
53Increased density of long bones (HP:0006392)2.22496407
54Papilloma (HP:0012740)2.18663165
55Verrucae (HP:0200043)2.18663165
56Broad face (HP:0000283)2.18038411
57Obstructive lung disease (HP:0006536)2.17643143
58Chronic obstructive pulmonary disease (HP:0006510)2.17643143
59Hemorrhage of the eye (HP:0011885)2.14012126
60Blue sclerae (HP:0000592)2.13703764
61Right ventricular cardiomyopathy (HP:0011663)2.13403565
62Premature rupture of membranes (HP:0001788)2.12816624
63Mediastinal lymphadenopathy (HP:0100721)2.12250005
64Increased variability in muscle fiber diameter (HP:0003557)2.11568765
65Thrombocytosis (HP:0001894)2.11560776
66T lymphocytopenia (HP:0005403)2.11109873
67Abnormal platelet function (HP:0011869)2.10364775
68Impaired platelet aggregation (HP:0003540)2.10364775
69Urticaria (HP:0001025)2.10052109
70Abnormality of macrophages (HP:0004311)2.08485764
71Malnutrition (HP:0004395)2.08329644
72Myocardial infarction (HP:0001658)2.08322483
73Systemic lupus erythematosus (HP:0002725)2.07948230
74Ankle contracture (HP:0006466)2.06855567
75Increased cerebral lipofuscin (HP:0011813)2.06849900
76Abnormality of T cells (HP:0002843)2.06043693
77Gastrointestinal stroma tumor (HP:0100723)2.04670108
78Abnormality of T cell physiology (HP:0011840)2.03936693
79Aneurysm (HP:0002617)2.03432815
80Abnormality of T cell number (HP:0011839)2.02569762
81Asymmetric septal hypertrophy (HP:0001670)2.00638955
82Gingival bleeding (HP:0000225)2.00512689
83Petechiae (HP:0000967)1.98081573
84Prolonged bleeding time (HP:0003010)1.97147715
85Osteolytic defects of the hand bones (HP:0009699)1.96926683
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.96926683
87Wormian bones (HP:0002645)1.95384763
88Obstructive sleep apnea (HP:0002870)1.94893214
89Abnormality of the peritoneum (HP:0002585)1.94064140
90Recurrent bacterial skin infections (HP:0005406)1.93914035
91Fatigue (HP:0012378)1.92517458
92Dilatation of the ascending aorta (HP:0005111)1.91578162
93Vasculitis (HP:0002633)1.90410673
94Genu recurvatum (HP:0002816)1.90155628
95Distal lower limb muscle weakness (HP:0009053)1.89872082
96Keratoconjunctivitis sicca (HP:0001097)1.88772021
97Panhypogammaglobulinemia (HP:0003139)1.88479636
98Esophageal varix (HP:0002040)1.87769074
99Flat acetabular roof (HP:0003180)1.86449933
100Lymphopenia (HP:0001888)1.85858374
101Purpura (HP:0000979)1.85540904
102Abnormality of skeletal muscle fiber size (HP:0012084)1.85126122
103Segmental peripheral demyelination/remyelination (HP:0003481)1.84015935
104Atrophic scars (HP:0001075)1.83983793
105Pulmonary infiltrates (HP:0002113)1.83509563
106Arterial thrombosis (HP:0004420)1.82546145
107Ulnar bowing (HP:0003031)1.82294993
108Slender build (HP:0001533)1.81171896
109Mitral valve prolapse (HP:0001634)1.81027240
110Chronic mucocutaneous candidiasis (HP:0002728)1.80773996
111Recurrent cutaneous fungal infections (HP:0011370)1.80773996
112Abnormality of cells of the lymphoid lineage (HP:0012140)1.79961360
113Abnormal platelet volume (HP:0011876)1.78936616
114Vertebral compression fractures (HP:0002953)1.76447414
115Persistence of primary teeth (HP:0006335)1.75097679
116Epistaxis (HP:0000421)1.74767365
117Bladder diverticulum (HP:0000015)1.74696961
118Broad metatarsal (HP:0001783)1.73924925
119Increased serum ferritin (HP:0003281)1.73339475
120Restrictive lung disease (HP:0002091)1.73210359
121Episodic fever (HP:0001954)1.73169861
122Recurrent skin infections (HP:0001581)1.73163032
123Osteomyelitis (HP:0002754)1.73035777
124Chronic diarrhea (HP:0002028)1.72627443
125Mitral regurgitation (HP:0001653)1.72392051
126Hypochromic anemia (HP:0001931)1.71172300
127Spinal rigidity (HP:0003306)1.70971052
128Disproportionate tall stature (HP:0001519)1.70778641
129Loss of speech (HP:0002371)1.70551034
130Premature loss of primary teeth (HP:0006323)1.70432178
131Hemoptysis (HP:0002105)1.70091861
132Joint stiffness (HP:0001387)1.70017541
133Abnormality of the pericardium (HP:0001697)1.69921861
134Stomatitis (HP:0010280)1.69892299
135Frequent falls (HP:0002359)1.69314876
136Skin ulcer (HP:0200042)1.69108459
137Chest pain (HP:0100749)1.68432150
138Orchitis (HP:0100796)1.67963759
139Abnormality of the fingertips (HP:0001211)1.67953004
140Increased neuronal autofluorescent lipopigment (HP:0002074)1.67929974
141Autoimmune hemolytic anemia (HP:0001890)1.67902276
142Ectopia lentis (HP:0001083)1.66691480
143Agammaglobulinemia (HP:0004432)1.66134359
144Hyperactive renin-angiotensin system (HP:0000841)1.65356164
145Mesangial abnormality (HP:0001966)1.65111015
146Periodontitis (HP:0000704)1.64877364
147Meningitis (HP:0001287)1.64797029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.08317475
2MAP4K13.81504990
3ERN13.80662926
4PKN22.73592808
5PRPF4B2.47055439
6RIPK42.45635875
7EEF2K2.44504508
8MAP3K102.42718881
9EPHB12.17423647
10JAK32.16791670
11STK102.11761540
12LRRK22.07239461
13ZAP702.03370517
14FGFR41.99568236
15TBK11.88936835
16TYK21.88415552
17TGFBR21.80593051
18PTK61.78792532
19TTN1.74718267
20SMG11.73855309
21KDR1.68315836
22SIK11.65547855
23BLK1.56302556
24GRK61.53125732
25RIPK11.47410742
26JAK11.42984588
27NME21.39830827
28MAP2K31.38456055
29BTK1.34007161
30ITK1.33314910
31IKBKE1.30402923
32CDC42BPA1.30305415
33CSK1.29960186
34TAOK21.28139950
35TAOK31.25000604
36EPHA31.24004630
37FLT31.22621693
38KIT1.22390195
39MAP3K141.22257128
40KSR21.18488418
41MST41.16623970
42RPS6KA41.14867607
43MAP3K31.14234129
44TXK1.13801171
45ICK1.11739754
46TNK21.08550738
47MARK21.05488156
48SCYL21.03429919
49STK381.03071921
50NLK1.02995074
51MAP3K61.02476123
52MAP3K111.01881741
53FES0.99624490
54TAOK10.97875451
55SIK30.97315580
56MAP2K20.96050995
57MAP3K70.95429443
58HCK0.94280379
59FGFR30.93282762
60PDPK10.91972097
61CSF1R0.90892015
62PIM20.90544495
63MYLK0.90509186
64MARK30.88990205
65LCK0.87581130
66TESK20.86500553
67PAK40.85664266
68DDR20.84420609
69SYK0.83769742
70JAK20.83367106
71FGR0.82326890
72IKBKB0.80181714
73TESK10.79994851
74MAP3K20.79986884
75TEC0.79914872
76RPS6KA20.79803765
77IRAK30.79564413
78PTK20.78744812
79CHUK0.76769039
80PDGFRA0.76515172
81DMPK0.73243267
82PRKG20.72432573
83PRKCH0.71266631
84LMTK20.70881561
85PTK2B0.70129571
86BMX0.68141372
87MAPKAPK30.67722810
88MST1R0.66770219
89MAPK70.66750021
90MAP3K10.66632638
91CDK120.66263483
92NEK90.65835319
93PIM10.65409617
94MAP3K80.64881118
95RPS6KC10.64545862
96RPS6KL10.64545862
97EPHB20.63890719
98PDK10.63126480
99HIPK20.62355559
100IRAK10.61755041
101IRAK20.58132256
102PRKD20.57881035
103TGFBR10.57561980
104MOS0.54972341
105ILK0.54018458
106PDGFRB0.53649277
107RPS6KB20.53034310
108MAPK150.51993412
109TRPM70.50141394
110PAK20.49899327
111TIE10.49799522
112CDK60.48850800
113RPS6KA60.48694426
114MAPK120.47731620
115YES10.47248972
116EPHA20.46864291
117MAP3K130.46783788
118MATK0.46209117
119FYN0.45581734
120MET0.45035435
121ARAF0.44790084
122MAPKAPK20.44627995
123DYRK1B0.44390858
124PRKD10.42629537
125CDK40.42448872
126LYN0.41231407
127MTOR0.40141144
128CAMK1D0.40108014
129RET0.38710008
130BCKDK0.38463628
131FRK0.37961335
132MAPK110.36707082
133ALK0.35469185
134IRAK40.35360740
135PRKCQ0.34400879

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.67595593
2Leishmaniasis_Homo sapiens_hsa051402.21961221
3B cell receptor signaling pathway_Homo sapiens_hsa046622.06673393
4Osteoclast differentiation_Homo sapiens_hsa043801.96707649
5Other glycan degradation_Homo sapiens_hsa005111.91952205
6Antigen processing and presentation_Homo sapiens_hsa046121.84608635
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.80147008
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79466659
9Leukocyte transendothelial migration_Homo sapiens_hsa046701.76745144
10Toxoplasmosis_Homo sapiens_hsa051451.74800007
11Measles_Homo sapiens_hsa051621.64260294
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.61334818
13Acute myeloid leukemia_Homo sapiens_hsa052211.57542969
14T cell receptor signaling pathway_Homo sapiens_hsa046601.56646547
15Chronic myeloid leukemia_Homo sapiens_hsa052201.56293253
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.54158201
17Hematopoietic cell lineage_Homo sapiens_hsa046401.51760887
18Lysosome_Homo sapiens_hsa041421.47568693
19Viral myocarditis_Homo sapiens_hsa054161.40957973
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40883890
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40159089
22Shigellosis_Homo sapiens_hsa051311.38457519
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36857560
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35388302
25Malaria_Homo sapiens_hsa051441.33668536
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.30920643
27Staphylococcus aureus infection_Homo sapiens_hsa051501.29407453
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27926595
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25478591
30Caffeine metabolism_Homo sapiens_hsa002321.23602205
31Small cell lung cancer_Homo sapiens_hsa052221.22829685
32Apoptosis_Homo sapiens_hsa042101.21497671
33Autoimmune thyroid disease_Homo sapiens_hsa053201.20967977
34TNF signaling pathway_Homo sapiens_hsa046681.19413220
35Pancreatic cancer_Homo sapiens_hsa052121.18655734
36Legionellosis_Homo sapiens_hsa051341.17579754
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16885188
38Pertussis_Homo sapiens_hsa051331.15741624
39Tuberculosis_Homo sapiens_hsa051521.14502428
40Phagosome_Homo sapiens_hsa041451.13144090
41Insulin resistance_Homo sapiens_hsa049311.11294738
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06341119
43Hepatitis B_Homo sapiens_hsa051611.05707722
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.05414431
45Platelet activation_Homo sapiens_hsa046111.05390521
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05096634
47Amoebiasis_Homo sapiens_hsa051461.04603960
48Focal adhesion_Homo sapiens_hsa045101.04199189
49Influenza A_Homo sapiens_hsa051641.03328424
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02774306
51Hepatitis C_Homo sapiens_hsa051601.00157306
52Salmonella infection_Homo sapiens_hsa051320.97358612
53African trypanosomiasis_Homo sapiens_hsa051430.96462592
54VEGF signaling pathway_Homo sapiens_hsa043700.93968530
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93429289
56ECM-receptor interaction_Homo sapiens_hsa045120.91769225
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90256163
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90115792
59Proteoglycans in cancer_Homo sapiens_hsa052050.87646891
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87612531
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.87440314
62Bladder cancer_Homo sapiens_hsa052190.86436162
63Herpes simplex infection_Homo sapiens_hsa051680.84995097
64Endometrial cancer_Homo sapiens_hsa052130.84556146
65Fat digestion and absorption_Homo sapiens_hsa049750.83797473
66Fatty acid degradation_Homo sapiens_hsa000710.83020647
67Prolactin signaling pathway_Homo sapiens_hsa049170.82648533
68Chemokine signaling pathway_Homo sapiens_hsa040620.78574623
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77689839
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77500881
71GnRH signaling pathway_Homo sapiens_hsa049120.76752296
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.76258305
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74581925
74Sulfur relay system_Homo sapiens_hsa041220.73562607
75Protein digestion and absorption_Homo sapiens_hsa049740.73388801
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72679472
77HTLV-I infection_Homo sapiens_hsa051660.72507456
78Type I diabetes mellitus_Homo sapiens_hsa049400.71136586
79Renin-angiotensin system_Homo sapiens_hsa046140.71040460
80PPAR signaling pathway_Homo sapiens_hsa033200.70843773
81Adherens junction_Homo sapiens_hsa045200.70455848
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69109914
83Prion diseases_Homo sapiens_hsa050200.69086644
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.68953984
85Complement and coagulation cascades_Homo sapiens_hsa046100.67617563
86Choline metabolism in cancer_Homo sapiens_hsa052310.67232048
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65910426
88Non-small cell lung cancer_Homo sapiens_hsa052230.65555837
89Pentose phosphate pathway_Homo sapiens_hsa000300.65139417
90Sulfur metabolism_Homo sapiens_hsa009200.65138536
91Thyroid cancer_Homo sapiens_hsa052160.63382750
92mTOR signaling pathway_Homo sapiens_hsa041500.63095439
93HIF-1 signaling pathway_Homo sapiens_hsa040660.61405399
94Rap1 signaling pathway_Homo sapiens_hsa040150.60536806
95Rheumatoid arthritis_Homo sapiens_hsa053230.60339652
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60176626
97ABC transporters_Homo sapiens_hsa020100.59637797
98Viral carcinogenesis_Homo sapiens_hsa052030.58305231
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57897373
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57712360
101FoxO signaling pathway_Homo sapiens_hsa040680.57659239
102Insulin signaling pathway_Homo sapiens_hsa049100.57545897
103Inositol phosphate metabolism_Homo sapiens_hsa005620.57190534
104Estrogen signaling pathway_Homo sapiens_hsa049150.56851322
105Endocytosis_Homo sapiens_hsa041440.56530186
106ErbB signaling pathway_Homo sapiens_hsa040120.56311361
107Allograft rejection_Homo sapiens_hsa053300.56107501
108Fructose and mannose metabolism_Homo sapiens_hsa000510.54958544
109N-Glycan biosynthesis_Homo sapiens_hsa005100.54587143
110Glioma_Homo sapiens_hsa052140.53258885
111Notch signaling pathway_Homo sapiens_hsa043300.52746482
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52099105
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51710521
114Renal cell carcinoma_Homo sapiens_hsa052110.51487659
115Lysine degradation_Homo sapiens_hsa003100.51380634
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51323733
117Bile secretion_Homo sapiens_hsa049760.51247276
118Galactose metabolism_Homo sapiens_hsa000520.50270829
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.48888856
120Selenocompound metabolism_Homo sapiens_hsa004500.48739474
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.46070815
122Starch and sucrose metabolism_Homo sapiens_hsa005000.44470360
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43578700
124Prostate cancer_Homo sapiens_hsa052150.43576152
125Graft-versus-host disease_Homo sapiens_hsa053320.43149923
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42708478

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