LRP11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.45930776
2cilium or flagellum-dependent cell motility (GO:0001539)6.56884544
3cilium movement (GO:0003341)6.15726897
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.84395188
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.83155659
6motile cilium assembly (GO:0044458)5.74293898
7synaptic vesicle maturation (GO:0016188)5.58089412
8synaptic vesicle exocytosis (GO:0016079)5.20424122
9epithelial cilium movement (GO:0003351)5.15409058
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.96882307
11regulation of synaptic vesicle exocytosis (GO:2000300)4.96309567
12locomotory exploration behavior (GO:0035641)4.94774911
13glutamate secretion (GO:0014047)4.88500788
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.51655396
15desmosome organization (GO:0002934)4.51364930
16vocalization behavior (GO:0071625)4.48781005
17regulation of synaptic vesicle transport (GO:1902803)4.40051773
18neuronal action potential propagation (GO:0019227)4.37979143
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.29818885
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.22664037
21neurotransmitter secretion (GO:0007269)4.18435546
22protein localization to synapse (GO:0035418)4.17091449
23regulation of glutamate receptor signaling pathway (GO:1900449)4.11986441
24neuron cell-cell adhesion (GO:0007158)4.10458209
25primary alcohol catabolic process (GO:0034310)4.06897117
26axoneme assembly (GO:0035082)4.01182566
27regulation of neuronal synaptic plasticity (GO:0048168)3.92646158
28exploration behavior (GO:0035640)3.90784257
29layer formation in cerebral cortex (GO:0021819)3.87000959
30activation of protein kinase A activity (GO:0034199)3.84872846
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.83900222
32left/right pattern formation (GO:0060972)3.82587583
33detection of calcium ion (GO:0005513)3.82126226
34proline transport (GO:0015824)3.78517568
35hemidesmosome assembly (GO:0031581)3.73971553
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.73052460
37vitamin transmembrane transport (GO:0035461)3.66108775
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.64000910
39synaptic transmission, glutamatergic (GO:0035249)3.56389330
40establishment of apical/basal cell polarity (GO:0035089)3.55906840
41lung epithelium development (GO:0060428)3.48062488
42innervation (GO:0060384)3.45898935
43glomerular epithelial cell development (GO:0072310)3.44541806
44neuron-neuron synaptic transmission (GO:0007270)3.43802763
45regulation of vesicle fusion (GO:0031338)3.43493867
46regulation of synapse structural plasticity (GO:0051823)3.40777169
47cellular potassium ion homeostasis (GO:0030007)3.39697255
48neurotransmitter transport (GO:0006836)3.38738008
49ethanol metabolic process (GO:0006067)3.38716663
50glutamate receptor signaling pathway (GO:0007215)3.38670637
51vesicle transport along microtubule (GO:0047496)3.36636578
52positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30974135
53gamma-aminobutyric acid transport (GO:0015812)3.29680592
54dendritic spine morphogenesis (GO:0060997)3.29473199
55positive regulation of synapse maturation (GO:0090129)3.29102330
56positive regulation of membrane potential (GO:0045838)3.28218038
57membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28140801
58neuromuscular process controlling posture (GO:0050884)3.28105924
59long-term memory (GO:0007616)3.25800743
60neuron recognition (GO:0008038)3.25051532
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24842052
62regulation of calcium ion-dependent exocytosis (GO:0017158)3.23942890
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.23897763
64regulation of neurotransmitter secretion (GO:0046928)3.21696048
65regulation of synaptic plasticity (GO:0048167)3.21043758
66insulin secretion (GO:0030073)3.20468333
67synaptic vesicle endocytosis (GO:0048488)3.20405790
68chemosensory behavior (GO:0007635)3.16865125
69diterpenoid biosynthetic process (GO:0016102)3.15694383
70cerebellar Purkinje cell layer development (GO:0021680)3.14776698
71regulation of postsynaptic membrane potential (GO:0060078)3.11660152
72cerebellar Purkinje cell differentiation (GO:0021702)3.09890236
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.09473630
74negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.07950227
75long-term synaptic potentiation (GO:0060291)3.07859174
76regulation of neurotransmitter levels (GO:0001505)3.06941304
77mating behavior (GO:0007617)3.06050453
78regulation of type B pancreatic cell apoptotic process (GO:2000674)3.03008554
79positive regulation of vesicle fusion (GO:0031340)3.01836455
80transmission of nerve impulse (GO:0019226)3.01768967
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01523765
82positive regulation of exocytosis (GO:0045921)3.01344861
83organelle transport along microtubule (GO:0072384)3.01226672
84cytoskeletal anchoring at plasma membrane (GO:0007016)3.00800014
85membrane depolarization during action potential (GO:0086010)3.00400735
86cell communication by electrical coupling (GO:0010644)2.99499965
87axonal fasciculation (GO:0007413)2.98483992
88microtubule bundle formation (GO:0001578)2.97385971
89neuromuscular process controlling balance (GO:0050885)2.97087680
90establishment of planar polarity (GO:0001736)2.96384641
91establishment of tissue polarity (GO:0007164)2.96384641
92gamma-aminobutyric acid signaling pathway (GO:0007214)2.95188550
93regulation of neurotransmitter transport (GO:0051588)2.94947947
94regulation of cilium movement (GO:0003352)2.94280991
95retinol metabolic process (GO:0042572)2.94033803
96establishment or maintenance of monopolar cell polarity (GO:0061339)2.93939852
97establishment of monopolar cell polarity (GO:0061162)2.93939852
98sodium ion export (GO:0071436)2.92731838
99Golgi transport vesicle coating (GO:0048200)2.92167688
100COPI coating of Golgi vesicle (GO:0048205)2.92167688
101neurotransmitter-gated ion channel clustering (GO:0072578)2.89704877
102glycine transport (GO:0015816)2.89644418
103positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89299276
104signal release (GO:0023061)2.87109718
105regulation of synaptic transmission, glutamatergic (GO:0051966)2.86789391
106regulation of exocytosis (GO:0017157)2.85377403
107apical protein localization (GO:0045176)2.85306022
108suckling behavior (GO:0001967)2.84126516
109membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.83674350
110synaptic transmission (GO:0007268)2.80722288
111calcium ion-dependent exocytosis (GO:0017156)2.79935978
112membrane depolarization (GO:0051899)2.78649610
113dendritic spine organization (GO:0097061)2.78624427
114negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78432766
115synaptic vesicle transport (GO:0048489)2.77757970
116establishment of synaptic vesicle localization (GO:0097480)2.77757970
117synapse assembly (GO:0007416)2.76315350
118G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.76181274
119regulation of dendritic spine morphogenesis (GO:0061001)2.75116617
120dendrite morphogenesis (GO:0048813)2.74540283
121positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.74356042
122fear response (GO:0042596)2.73497503
123multicellular organismal water homeostasis (GO:0050891)2.73043052
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.73036953
125cellular response to glucagon stimulus (GO:0071377)2.71956852
126ethanol oxidation (GO:0006069)2.71151310
127establishment of vesicle localization (GO:0051650)2.71077001
128regulation of synaptic transmission (GO:0050804)2.70499366
129left/right axis specification (GO:0070986)2.69617590
130intraspecies interaction between organisms (GO:0051703)2.68946117
131ventricular system development (GO:0021591)2.68702052
132negative regulation of humoral immune response (GO:0002921)2.65026137
133intraciliary transport (GO:0042073)2.61866125
134cell adhesion mediated by integrin (GO:0033627)2.57204527
135iron ion import (GO:0097286)2.56163633
136cilium organization (GO:0044782)2.53266831
137cilium assembly (GO:0042384)2.52149966
138dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52136208
139protein retention in ER lumen (GO:0006621)2.51347364
140skin morphogenesis (GO:0043589)2.50973448
141regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.49368347
142macroautophagy (GO:0016236)2.48875869
143maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.48570068
144pyrimidine-containing compound transmembrane transport (GO:0072531)2.47809781
145cellular zinc ion homeostasis (GO:0006882)2.45672010
146asymmetric protein localization (GO:0008105)2.43315360
147protein localization to cilium (GO:0061512)2.40461184
148retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.37523536
149microtubule-based movement (GO:0007018)2.37321049
150COPII vesicle coating (GO:0048208)2.36291788
151primary alcohol metabolic process (GO:0034308)2.35171508
152water homeostasis (GO:0030104)2.33440166
153one-carbon compound transport (GO:0019755)2.29612765
154regulation of metalloenzyme activity (GO:0048552)2.28089032
155potassium ion homeostasis (GO:0055075)2.25751949
156intestinal epithelial cell development (GO:0060576)2.23505288
157bundle of His cell to Purkinje myocyte communication (GO:0086069)2.22933230
158regulation of water loss via skin (GO:0033561)2.22089100
159terpenoid biosynthetic process (GO:0016114)2.20900857
160positive regulation of smoothened signaling pathway (GO:0045880)2.20506876
161negative regulation of hormone metabolic process (GO:0032351)2.19253066
162regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.19223039
163regulation of extracellular matrix disassembly (GO:0010715)2.15802718
164regulation of autophagic vacuole assembly (GO:2000785)2.15674939
165negative regulation of dendrite morphogenesis (GO:0050774)2.15152336
166sphingomyelin metabolic process (GO:0006684)2.14378924
167establishment or maintenance of bipolar cell polarity (GO:0061245)2.13730273
168establishment or maintenance of apical/basal cell polarity (GO:0035088)2.13730273
169myelin maintenance (GO:0043217)2.11881995
170protein carboxylation (GO:0018214)2.09859865
171peptidyl-glutamic acid carboxylation (GO:0017187)2.09859865
172epithelial cell-cell adhesion (GO:0090136)2.09535167
173positive regulation of actin filament depolymerization (GO:0030836)2.09397283
174regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.08530953
175negative regulation of complement activation (GO:0045916)2.08289578
176O-glycan processing (GO:0016266)2.07703067
177cellular component assembly involved in morphogenesis (GO:0010927)2.07245577
178positive regulation of macroautophagy (GO:0016239)2.04533994
179protein localization to endosome (GO:0036010)2.04265840
180retinoic acid metabolic process (GO:0042573)2.03544128
181hypotonic response (GO:0006971)2.03060521
182zinc ion transmembrane transport (GO:0071577)2.02986636
183glandular epithelial cell differentiation (GO:0002067)2.02387851
184negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.02185788
185embryonic retina morphogenesis in camera-type eye (GO:0060059)2.01598639
186epithelial cell fate commitment (GO:0072148)2.01250467
187protein maturation by protein folding (GO:0022417)2.00944813
188negative regulation of hormone biosynthetic process (GO:0032353)2.00873830
189positive regulation of protein autophosphorylation (GO:0031954)2.00818425
190negative regulation of chondrocyte differentiation (GO:0032331)1.99612000
191polarized epithelial cell differentiation (GO:0030859)1.99388573
192sodium ion homeostasis (GO:0055078)1.98393461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.99352370
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.39252429
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.67697955
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.64479999
5GBX2_23144817_ChIP-Seq_PC3_Human3.34073203
6* REST_21632747_ChIP-Seq_MESCs_Mouse3.11445746
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09890618
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92359524
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88873163
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.69033760
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.67165204
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62378260
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59123449
14* REST_18959480_ChIP-ChIP_MESCs_Mouse2.56839544
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55209634
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55209634
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49461011
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49443738
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48564249
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.43626079
21ZNF263_19887448_ChIP-Seq_K562_Human2.35325911
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32759326
23DROSHA_22980978_ChIP-Seq_HELA_Human2.31918874
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.30269018
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27368592
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.20711220
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18677208
28ESR1_21235772_ChIP-Seq_MCF-7_Human2.12106781
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.11216250
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.10906863
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06628233
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04973152
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88788109
34FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.87391241
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83405269
36SOX2_20726797_ChIP-Seq_SW620_Human1.82920448
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80503362
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73860649
39ZNF274_21170338_ChIP-Seq_K562_Hela1.73194631
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.72807573
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.70702188
42SMAD4_21799915_ChIP-Seq_A2780_Human1.68253569
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67503640
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.61914436
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61024315
46IGF1R_20145208_ChIP-Seq_DFB_Human1.60595072
47TP53_18474530_ChIP-ChIP_U2OS_Human1.58916855
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57589184
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57545529
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.57031162
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56373973
52CLOCK_20551151_ChIP-Seq_293T_Human1.55774933
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53128833
54* FOXO3_23340844_ChIP-Seq_DLD1_Human1.52375839
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51927976
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50956430
57* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49502672
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.48239266
59FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.48056137
60TAF15_26573619_Chip-Seq_HEK293_Human1.45154377
61CDX2_20551321_ChIP-Seq_CACO-2_Human1.43854672
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43652127
63CTNNB1_20460455_ChIP-Seq_HCT116_Human1.42342911
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.39327644
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.39217742
66* FOXA2_19822575_ChIP-Seq_HepG2_Human1.38512866
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36826817
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36538549
69AR_21572438_ChIP-Seq_LNCaP_Human1.36119399
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35607387
71* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35567946
72* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35567946
73TP63_23658742_ChIP-Seq_EP156T_Human1.34408976
74* STAT3_23295773_ChIP-Seq_U87_Human1.31778658
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31598166
76P300_19829295_ChIP-Seq_ESCs_Human1.26281306
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26155559
78* CJUN_26792858_Chip-Seq_BT549_Human1.25681313
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24977054
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.24652867
81AR_19668381_ChIP-Seq_PC3_Human1.24606359
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24290897
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23858594
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23795373
85GATA3_24758297_ChIP-Seq_MCF-7_Human1.23009304
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22858647
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21929442
88P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20920387
89* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20069766
90* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19485565
91FOXA1_25552417_ChIP-Seq_VCAP_Human1.19448063
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19253056
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.18519954
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17971734
95* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17939972
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.17267594
97AR_25329375_ChIP-Seq_VCAP_Human1.16705127
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16635720
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15045496
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14179510
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13775813
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13286996
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13193721
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13014654
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12593627
106KDM2B_26808549_Chip-Seq_K562_Human1.11391283
107NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11364585
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11364585
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11257300
110RACK7_27058665_Chip-Seq_MCF-7_Human1.11069572
111RUNX1_27514584_Chip-Seq_MCF-7_Human1.09477902
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09330036
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09225634
114SMAD3_21741376_ChIP-Seq_ESCs_Human1.09076332
115EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08930455
116AR_21909140_ChIP-Seq_LNCAP_Human1.08826522
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07577179
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07544683
119VDR_22108803_ChIP-Seq_LS180_Human1.07233806
120RING1B_27294783_Chip-Seq_NPCs_Mouse1.06807854
121* KLF5_25053715_ChIP-Seq_YYC3_Human1.06573350
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06452508
123TCF4_23295773_ChIP-Seq_U87_Human1.05613502
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05333737
125* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04980164
126WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04868353
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04562126
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03803667
129RNF2_27304074_Chip-Seq_NSC_Mouse1.03098147
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02251686
131GATA4_25053715_ChIP-Seq_YYC3_Human1.01551208
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00082834
133RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98713591
134* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98033270
135RUNX2_22187159_ChIP-Seq_PCA_Human0.97616721
136TET1_21490601_ChIP-Seq_MESCs_Mouse0.97461388
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97300402
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97151811
139POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95006930
140ARNT_22903824_ChIP-Seq_MCF-7_Human0.94910550
141TP53_16413492_ChIP-PET_HCT116_Human0.94901536
142CBX2_27304074_Chip-Seq_ESCs_Mouse0.94849485
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93284514
144P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92946592
145BCAT_22108803_ChIP-Seq_LS180_Human0.92911890
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.92716248
147LXR_22158963_ChIP-Seq_LIVER_Mouse0.92474343
148RXR_22158963_ChIP-Seq_LIVER_Mouse0.92404718
149AHR_22903824_ChIP-Seq_MCF-7_Human0.91140750
150CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90274688
151GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87005400
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86204537
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85905047
154TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85147884
155MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84590719
156TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84422494
157CTCF_27219007_Chip-Seq_Bcells_Human0.83943608
158BRD4_25478319_ChIP-Seq_HGPS_Human0.83859899
159SMAD3_21741376_ChIP-Seq_HESCs_Human0.83796718
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83210334
161STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.81776830
162TCF4_18268006_ChIP-ChIP_LS174T_Human0.81663185
163SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80306751
164WT1_19549856_ChIP-ChIP_CCG9911_Human0.79411084

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.53185917
2MP0003880_abnormal_central_pattern3.84002671
3MP0004270_analgesia3.72920459
4MP0003635_abnormal_synaptic_transmissio3.70970402
5MP0000566_synostosis3.02908656
6MP0002063_abnormal_learning/memory/cond2.93669588
7MP0009745_abnormal_behavioral_response2.90418699
8MP0002909_abnormal_adrenal_gland2.89129848
9MP0009780_abnormal_chondrocyte_physiolo2.81126856
10MP0002064_seizures2.71160787
11MP0005623_abnormal_meninges_morphology2.69805382
12MP0002734_abnormal_mechanical_nocicepti2.69156308
13MP0001968_abnormal_touch/_nociception2.65585876
14MP0002572_abnormal_emotion/affect_behav2.49297871
15MP0009046_muscle_twitch2.48289730
16MP0003283_abnormal_digestive_organ2.42985247
17MP0002822_catalepsy2.39460119
18MP0002272_abnormal_nervous_system2.35907429
19MP0002735_abnormal_chemical_nociception2.35193274
20MP0010678_abnormal_skin_adnexa2.32530145
21MP0002733_abnormal_thermal_nociception2.28667712
22MP0000579_abnormal_nail_morphology2.26957053
23MP0008875_abnormal_xenobiotic_pharmacok2.22389008
24MP0000013_abnormal_adipose_tissue2.12400022
25MP0005423_abnormal_somatic_nervous2.12048889
26MP0001970_abnormal_pain_threshold2.06913396
27MP0001501_abnormal_sleep_pattern1.99208636
28MP0004858_abnormal_nervous_system1.98819830
29MP0002736_abnormal_nociception_after1.94851185
30MP0008438_abnormal_cutaneous_collagen1.94785793
31MP0001486_abnormal_startle_reflex1.93861454
32MP0010386_abnormal_urinary_bladder1.92432875
33MP0004272_abnormal_basement_membrane1.89638448
34MP0001440_abnormal_grooming_behavior1.88545242
35MP0005646_abnormal_pituitary_gland1.87269559
36MP0003941_abnormal_skin_development1.85343358
37MP0002184_abnormal_innervation1.85227638
38MP0003566_abnormal_cell_adhesion1.82076969
39MP0001984_abnormal_olfaction1.81742612
40MP0006276_abnormal_autonomic_nervous1.80850114
41MP0003329_amyloid_beta_deposits1.79827995
42MP0005645_abnormal_hypothalamus_physiol1.79039446
43MP0000383_abnormal_hair_follicle1.77925525
44MP0002067_abnormal_sensory_capabilities1.77846151
45MP0003122_maternal_imprinting1.75525319
46MP0002060_abnormal_skin_morphology1.68741366
47MP0004811_abnormal_neuron_physiology1.67974345
48MP0002557_abnormal_social/conspecific_i1.64458904
49MP0010352_gastrointestinal_tract_polyps1.64113221
50MP0000955_abnormal_spinal_cord1.62237327
51MP0003705_abnormal_hypodermis_morpholog1.60632666
52MP0005257_abnormal_intraocular_pressure1.59721883
53MP0008569_lethality_at_weaning1.57267057
54MP0002796_impaired_skin_barrier1.56582204
55MP0005409_darkened_coat_color1.55853423
56MP0003879_abnormal_hair_cell1.54399928
57MP0004043_abnormal_pH_regulation1.54111504
58MP0005275_abnormal_skin_tensile1.53737976
59MP0002837_dystrophic_cardiac_calcinosis1.52376883
60MP0005386_behavior/neurological_phenoty1.50985241
61MP0004924_abnormal_behavior1.50985241
62MP0000778_abnormal_nervous_system1.47636811
63MP0004019_abnormal_vitamin_homeostasis1.42260733
64MP0005248_abnormal_Harderian_gland1.41776520
65MP0000762_abnormal_tongue_morphology1.40758269
66MP0003787_abnormal_imprinting1.36833175
67MP0002693_abnormal_pancreas_physiology1.35233771
68MP0002877_abnormal_melanocyte_morpholog1.33842080
69MP0002638_abnormal_pupillary_reflex1.33386785
70MP0002896_abnormal_bone_mineralization1.32396627
71MP0002882_abnormal_neuron_morphology1.32019822
72MP0002066_abnormal_motor_capabilities/c1.29254229
73MP0001502_abnormal_circadian_rhythm1.29072528
74MP0005379_endocrine/exocrine_gland_phen1.25352943
75MP0008961_abnormal_basal_metabolism1.24798639
76MP0001944_abnormal_pancreas_morphology1.24587265
77MP0003633_abnormal_nervous_system1.23270399
78MP0006072_abnormal_retinal_apoptosis1.16178314
79MP0003453_abnormal_keratinocyte_physiol1.15067835
80MP0004885_abnormal_endolymph1.13561745
81MP0001529_abnormal_vocalization1.12799556
82MP0003183_abnormal_peptide_metabolism1.11458120
83MP0004145_abnormal_muscle_electrophysio1.11112726
84MP0002098_abnormal_vibrissa_morphology1.10770259
85MP0010771_integument_phenotype1.04305297
86MP0000467_abnormal_esophagus_morphology1.02852783
87MP0002160_abnormal_reproductive_system1.02073914
88MP0000631_abnormal_neuroendocrine_gland1.00647111
89MP0004133_heterotaxia1.00468283
90MP0005501_abnormal_skin_physiology0.99619164
91MP0005535_abnormal_body_temperature0.99539559
92MP0002152_abnormal_brain_morphology0.99111784
93MP0005365_abnormal_bile_salt0.98709614
94MP0002168_other_aberrant_phenotype0.98580624
95MP0003950_abnormal_plasma_membrane0.98169579
96MP0002069_abnormal_eating/drinking_beha0.97295028
97MP0003631_nervous_system_phenotype0.96880478
98MP0002229_neurodegeneration0.95887716
99MP0001346_abnormal_lacrimal_gland0.95874865
100MP0002295_abnormal_pulmonary_circulatio0.94699441
101MP0000427_abnormal_hair_cycle0.94334487
102MP0001905_abnormal_dopamine_level0.93376545
103MP0002139_abnormal_hepatobiliary_system0.91805404
104MP0001216_abnormal_epidermal_layer0.91583778
105MP0005083_abnormal_biliary_tract0.91289791
106MP0005220_abnormal_exocrine_pancreas0.90817332
107MP0003172_abnormal_lysosome_physiology0.90813130
108MP0001849_ear_inflammation0.90624734
109MP0010030_abnormal_orbit_morphology0.90498977
110MP0001986_abnormal_taste_sensitivity0.90120319
111MP0001188_hyperpigmentation0.88465780
112MP0004142_abnormal_muscle_tone0.88240978
113MP0000003_abnormal_adipose_tissue0.88073301
114MP0002282_abnormal_trachea_morphology0.87953751
115MP0000537_abnormal_urethra_morphology0.87808513
116MP0002078_abnormal_glucose_homeostasis0.87787123
117MP0005187_abnormal_penis_morphology0.87455404
118MP0000462_abnormal_digestive_system0.86807983
119MP0005023_abnormal_wound_healing0.86610485
120MP0005503_abnormal_tendon_morphology0.86121167
121MP0001756_abnormal_urination0.85618220
122MP0004264_abnormal_extraembryonic_tissu0.85264828
123MP0002234_abnormal_pharynx_morphology0.85235685
124MP0003634_abnormal_glial_cell0.84699639
125MP0010234_abnormal_vibrissa_follicle0.84684918
126MP0005499_abnormal_olfactory_system0.84290171
127MP0005394_taste/olfaction_phenotype0.84290171
128MP0001299_abnormal_eye_distance/0.84069606
129MP0003868_abnormal_feces_composition0.80278423
130MP0000678_abnormal_parathyroid_gland0.78810419
131MP0003942_abnormal_urinary_system0.78774056
132MP0005408_hypopigmentation0.78606467
133MP0002876_abnormal_thyroid_physiology0.77776683
134MP0005551_abnormal_eye_electrophysiolog0.75924622
135MP0002751_abnormal_autonomic_nervous0.75540836
136MP0004782_abnormal_surfactant_physiolog0.75363360
137MP0000639_abnormal_adrenal_gland0.74701164
138MP0002233_abnormal_nose_morphology0.74523978
139MP0004085_abnormal_heartbeat0.74469344
140MP0004233_abnormal_muscle_weight0.74006166
141MP0000377_abnormal_hair_follicle0.72850398
142MP0000647_abnormal_sebaceous_gland0.71869709
143MP0005636_abnormal_mineral_homeostasis0.71653751
144MP0001270_distended_abdomen0.69593828
145MP0003953_abnormal_hormone_level0.69519171
146MP0005165_increased_susceptibility_to0.69129863
147MP0002090_abnormal_vision0.69079698
148MP0003937_abnormal_limbs/digits/tail_de0.68573731
149MP0003123_paternal_imprinting0.68345177
150MP0002752_abnormal_somatic_nervous0.68086693
151MP0001963_abnormal_hearing_physiology0.67779326
152MP0001765_abnormal_ion_homeostasis0.67716236
153MP0000534_abnormal_ureter_morphology0.67500384
154MP0001664_abnormal_digestion0.67327950
155MP0002653_abnormal_ependyma_morphology0.66689363
156MP0000604_amyloidosis0.66547239
157MP0002249_abnormal_larynx_morphology0.65716161
158MP0003632_abnormal_nervous_system0.65367978
159MP0008872_abnormal_physiological_respon0.63619504
160MP0008789_abnormal_olfactory_epithelium0.63408129
161MP0001958_emphysema0.62282130
162MP0003195_calcinosis0.61863328
163MP0003119_abnormal_digestive_system0.61457130
164MP0000627_abnormal_mammary_gland0.58780562
165MP0003755_abnormal_palate_morphology0.57696125

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.12731746
2Abnormal respiratory motile cilium morphology (HP:0005938)7.00496537
3Abnormal respiratory epithelium morphology (HP:0012253)7.00496537
4Abnormal respiratory motile cilium physiology (HP:0012261)6.99244182
5Rhinitis (HP:0012384)6.92612921
6Abnormal ciliary motility (HP:0012262)6.77029068
7Dynein arm defect of respiratory motile cilia (HP:0012255)6.61543247
8Absent/shortened dynein arms (HP:0200106)6.61543247
9Focal motor seizures (HP:0011153)6.15672472
10Visual hallucinations (HP:0002367)5.45113167
11Myokymia (HP:0002411)5.35611215
12Chronic bronchitis (HP:0004469)5.24706578
13Focal seizures (HP:0007359)4.75883118
14Bronchiectasis (HP:0002110)4.50863002
15Atonic seizures (HP:0010819)4.50673449
16Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.23412590
17Epileptic encephalopathy (HP:0200134)4.06387388
18Absence seizures (HP:0002121)3.98274641
19Nasal polyposis (HP:0100582)3.86311543
20Febrile seizures (HP:0002373)3.60848611
21Dialeptic seizures (HP:0011146)3.55787437
22Progressive cerebellar ataxia (HP:0002073)3.54641340
23Generalized tonic-clonic seizures (HP:0002069)3.48598200
24Action tremor (HP:0002345)3.42977762
25Supranuclear gaze palsy (HP:0000605)3.34947304
26Papilledema (HP:0001085)3.28407120
27Agitation (HP:0000713)3.21606374
28Depression (HP:0000716)3.18756891
29Abnormality of the nasal mucosa (HP:0000433)3.15438801
30Pheochromocytoma (HP:0002666)3.10785349
31Epileptiform EEG discharges (HP:0011182)3.08063510
32EEG with generalized epileptiform discharges (HP:0011198)3.04030433
33Hyperinsulinemic hypoglycemia (HP:0000825)3.03740576
34Ankle clonus (HP:0011448)3.01904046
35Truncal ataxia (HP:0002078)2.92650194
36Hypsarrhythmia (HP:0002521)2.91190480
37Infertility (HP:0000789)2.89984897
38Anxiety (HP:0000739)2.89617940
39Poor eye contact (HP:0000817)2.83907775
40Abnormality of calcium-phosphate metabolism (HP:0100530)2.83625460
41Amblyopia (HP:0000646)2.81596134
42Vascular calcification (HP:0004934)2.80066005
43Cardiovascular calcification (HP:0011915)2.73413100
44Male infertility (HP:0003251)2.70919992
45Impaired smooth pursuit (HP:0007772)2.69212201
46Neuroendocrine neoplasm (HP:0100634)2.68801043
47Occipital encephalocele (HP:0002085)2.64757372
48Abnormal social behavior (HP:0012433)2.61053009
49Impaired social interactions (HP:0000735)2.61053009
50Cerebral inclusion bodies (HP:0100314)2.60839479
51Hyperactive renin-angiotensin system (HP:0000841)2.60468493
52Atelectasis (HP:0100750)2.60065798
53Failure to thrive in infancy (HP:0001531)2.58675977
54Hypercortisolism (HP:0001578)2.57006767
55Impaired vibration sensation in the lower limbs (HP:0002166)2.56899266
56Short nail (HP:0001799)2.49652479
57Hyperventilation (HP:0002883)2.45622617
58Gaze-evoked nystagmus (HP:0000640)2.43363490
59Hemiparesis (HP:0001269)2.43354436
60Hypoglycemic seizures (HP:0002173)2.43240814
61Drooling (HP:0002307)2.42865066
62Excessive salivation (HP:0003781)2.42865066
63Dysdiadochokinesis (HP:0002075)2.42405942
64Limb dystonia (HP:0002451)2.41649766
65Abnormality of dentin (HP:0010299)2.41571595
66Premature rupture of membranes (HP:0001788)2.41012133
67Dysmetria (HP:0001310)2.38504371
68Neurofibrillary tangles (HP:0002185)2.35457431
69Broad-based gait (HP:0002136)2.34589588
70Abnormal eating behavior (HP:0100738)2.34295068
71Menstrual irregularities (HP:0000858)2.29988546
72Atrophic scars (HP:0001075)2.29106588
73Abnormality of the lower motor neuron (HP:0002366)2.28848947
74Urinary bladder sphincter dysfunction (HP:0002839)2.28176212
75Hand muscle atrophy (HP:0009130)2.23179975
76Bradykinesia (HP:0002067)2.22634366
77Postural instability (HP:0002172)2.22340954
78Ventricular fibrillation (HP:0001663)2.21646384
79Abnormality of ocular smooth pursuit (HP:0000617)2.20793429
80Resting tremor (HP:0002322)2.19126690
81Insidious onset (HP:0003587)2.18191198
82Termporal pattern (HP:0011008)2.18191198
83Megalencephaly (HP:0001355)2.17796495
84Symptomatic seizures (HP:0011145)2.16322498
85Spastic gait (HP:0002064)2.16026181
86Genetic anticipation (HP:0003743)2.11300969
87Arterial tortuosity (HP:0005116)2.08312664
88Dysautonomia (HP:0002459)2.06258022
89Hypoventilation (HP:0002791)2.05675299
90Postural tremor (HP:0002174)2.05338340
91Mitral stenosis (HP:0001718)2.02683581
92Abnormality of permanent molar morphology (HP:0011071)2.00986786
93Abnormality of the dental root (HP:0006486)2.00986786
94Taurodontia (HP:0000679)2.00986786
95Absent speech (HP:0001344)2.00886673
96Protrusio acetabuli (HP:0003179)2.00346679
97Restlessness (HP:0000711)1.99590694
98Vascular tortuosity (HP:0004948)1.98645728
99Retinal dysplasia (HP:0007973)1.98067794
100Hyperparathyroidism (HP:0000843)1.97930322
101Abnormality of molar (HP:0011077)1.97256751
102Abnormality of molar morphology (HP:0011070)1.97256751
103Upper limb amyotrophy (HP:0009129)1.96507461
104Distal upper limb amyotrophy (HP:0007149)1.96507461
105Diplopia (HP:0000651)1.95411139
106Abnormality of binocular vision (HP:0011514)1.95411139
107Torticollis (HP:0000473)1.94939253
108Type II lissencephaly (HP:0007260)1.94897263
109Decreased circulating renin level (HP:0003351)1.94261556
110Progressive inability to walk (HP:0002505)1.93183291
111Mutism (HP:0002300)1.93058774
112Urinary urgency (HP:0000012)1.92226193
113Scanning speech (HP:0002168)1.92005708
114Bronchitis (HP:0012387)1.89985507
115Recurrent otitis media (HP:0000403)1.89936421
116Bifid scrotum (HP:0000048)1.89759452
117Focal dystonia (HP:0004373)1.89076040
118Bell-shaped thorax (HP:0001591)1.87611737
119Gait ataxia (HP:0002066)1.86580086
120Neoplasm of the peripheral nervous system (HP:0100007)1.85861564
121Clonus (HP:0002169)1.85670134
122Popliteal pterygium (HP:0009756)1.85260349
123Global brain atrophy (HP:0002283)1.85068775
124Abnormality of the distal phalanges of the toes (HP:0010182)1.84766199
125True hermaphroditism (HP:0010459)1.84443261
126Stereotypic behavior (HP:0000733)1.84199879
127Psychosis (HP:0000709)1.83581340
128Glucose intolerance (HP:0000833)1.82383910
129Pancreatic fibrosis (HP:0100732)1.81722098
130Retinal atrophy (HP:0001105)1.80544218
131Onycholysis (HP:0001806)1.80352162
132Abnormality of the dental pulp (HP:0006479)1.77916184
133Insomnia (HP:0100785)1.77748729
134Insulin-resistant diabetes mellitus (HP:0000831)1.77696165
135Intention tremor (HP:0002080)1.77679581
136Cystic liver disease (HP:0006706)1.77525657
137Bundle branch block (HP:0011710)1.77341570
138Generalized myoclonic seizures (HP:0002123)1.77165667
139Hypoplasia of dental enamel (HP:0006297)1.76048209
140Amyotrophic lateral sclerosis (HP:0007354)1.76014618
141Delusions (HP:0000746)1.75942861
142Right ventricular cardiomyopathy (HP:0011663)1.74397598
143Neuronal loss in central nervous system (HP:0002529)1.73798924
144Rapidly progressive (HP:0003678)1.73635754
145Blue irides (HP:0000635)1.73258459
146Ketoacidosis (HP:0001993)1.73148730
147Lower limb muscle weakness (HP:0007340)1.73035859
148Nuclear cataract (HP:0100018)1.72411974
149Status epilepticus (HP:0002133)1.72214984
150Ankyloglossia (HP:0010296)1.71503313
151Abnormality of aromatic amino acid family metabolism (HP:0004338)1.70963549
152Buphthalmos (HP:0000557)1.69596486
153Spinal cord compression (HP:0002176)1.68677929
154Absent frontal sinuses (HP:0002688)1.65194922
155Hyperaldosteronism (HP:0000859)1.64515768
156Congenital glaucoma (HP:0001087)1.63822410
157Plantar hyperkeratosis (HP:0007556)1.62720179
158Pterygium (HP:0001059)1.59964886
159Chronic sinusitis (HP:0011109)1.58223932
160Long toe (HP:0010511)1.57921129
161Natal tooth (HP:0000695)1.57327563
162Renal salt wasting (HP:0000127)1.56647001
163Bronchomalacia (HP:0002780)1.56228862
164Advanced eruption of teeth (HP:0006288)1.56114636
165Aplasia involving bones of the upper limbs (HP:0009823)1.52980211
166Aplasia of the phalanges of the hand (HP:0009802)1.52980211
167Aplasia involving bones of the extremities (HP:0009825)1.52980211
168Pili torti (HP:0003777)1.51968097
169Cervical subluxation (HP:0003308)1.51757861
170Postaxial foot polydactyly (HP:0001830)1.48345141
171Flat acetabular roof (HP:0003180)1.48300662
172Hyperphosphatemia (HP:0002905)1.48068381
173Furrowed tongue (HP:0000221)1.47320063
174Coronal craniosynostosis (HP:0004440)1.46089467
175Milia (HP:0001056)1.44275096
176Hypotension (HP:0002615)1.43703637
177Hypoplastic labia majora (HP:0000059)1.41138803
178Short thorax (HP:0010306)1.41017871
179Hyperglycemia (HP:0003074)1.40767552
180Hyperkalemia (HP:0002153)1.40644866
181Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.40572726
182Tubular atrophy (HP:0000092)1.39573907
183Hypoglycemic coma (HP:0001325)1.38795883
184Palmoplantar hyperkeratosis (HP:0000972)1.37324425
185Fragile skin (HP:0001030)1.36875795
186Abnormality of nail color (HP:0100643)1.36675497
187Stridor (HP:0010307)1.36477211
188Hydroureter (HP:0000072)1.34660905
189Fetal akinesia sequence (HP:0001989)1.34016675
190Abnormality of carpal bone ossification (HP:0006257)1.32280746
191Fragile nails (HP:0001808)1.32208475
192Septate vagina (HP:0001153)1.32155293
193Aplasia/Hypoplasia of the tongue (HP:0010295)1.29459951
194Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.29314829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.73578730
2EPHA24.65816834
3MAP3K93.95672997
4EPHA43.33557415
5MST1R3.18455485
6MST42.96095976
7MAP3K42.83475880
8NTRK12.82167632
9PRKD32.79391003
10KSR22.57201415
11MINK12.51518836
12MARK12.51129554
13TESK12.47783536
14MAP3K22.32959086
15MET2.27203326
16DAPK22.19671839
17MAP2K72.16133417
18PAK62.07867114
19INSRR2.00282987
20LIMK11.90022565
21RIPK41.76508117
22CAMKK11.76086258
23LATS11.74490311
24PNCK1.73400545
25MAP2K41.72087759
26GRK51.71524366
27ARAF1.69882395
28CAMKK21.68764006
29EEF2K1.63622040
30MAPKAPK31.62497374
31UHMK11.58981005
32STK241.57381263
33NTRK21.56412824
34MAP3K121.56404427
35TRIB31.53468414
36TRPM71.52231585
37CDK51.48614100
38KSR11.46427134
39DAPK11.40694389
40SCYL21.35675891
41WNK31.35060224
42ICK1.33652289
43FGFR21.31445993
44PLK21.29265822
45STK38L1.29218532
46ERBB31.26147444
47MAP3K11.21428841
48PRKCG1.20805096
49PAK41.19200967
50RET1.16606212
51CASK1.14394115
52MAPK151.13727141
53PAK31.11857651
54EIF2AK11.11713868
55STK391.10934332
56PASK1.07257468
57STK381.05937654
58HIPK21.05401036
59FGFR31.03956962
60MAPK130.98064320
61PRKCH0.95213055
62PHKG20.93551786
63PHKG10.93551786
64FER0.91558185
65SIK20.91058048
66CAMK2A0.90304412
67BCR0.90246994
68MYLK0.89947025
69NEK60.88556887
70CDK140.87857405
71CAMK2B0.85760930
72LATS20.81063245
73SMG10.80325565
74MAP3K130.80304744
75CDK180.80024109
76CDK150.79436689
77ALK0.78219376
78TYRO30.77678831
79BMPR20.76251158
80ROCK20.75663499
81SGK4940.75655871
82SGK2230.75655871
83STK30.74795588
84SIK10.74754032
85CDK190.74493868
86BRSK10.73354264
87CSNK1G20.72787204
88TTK0.72189765
89CDC42BPA0.71739139
90PRKCI0.71596654
91WNK40.71567163
92FES0.69193128
93TAOK10.68347946
94CDK11A0.68053006
95BRAF0.68032880
96RAF10.67065331
97STK110.66847526
98PRPF4B0.66269636
99DYRK1A0.66214720
100CCNB10.65924985
101WNK10.65065428
102PDGFRA0.63474198
103MAP2K10.63171945
104CAMK1G0.62044469
105PRKCE0.61690770
106CAMK2D0.61365392
107EPHB20.60379131
108CAMK10.60211388
109ROCK10.60171759
110FRK0.59644053
111MAP3K30.59489132
112PTK2B0.59219863
113EPHB10.58943899
114TNIK0.58507245
115MARK20.58325916
116PTK20.57343598
117NEK10.57266597
118NME10.55396986
119AKT30.54338230
120SGK10.54155321
121SGK20.52906110
122FGFR40.52660032
123LMTK20.52235538
124PINK10.51731738
125ILK0.51470964
126PDPK10.51168599
127ERBB40.50446715
128BRSK20.50107106
129IRAK30.47502382
130PRKG20.47062823
131MAPK100.46988527
132PDK10.46426106
133RPS6KB20.45110008
134AKT20.44181519
135RPS6KA30.43504365
136CAMK2G0.42401445
137PTK60.42034485
138PRKAA20.41626327
139TSSK60.41616331
140MAP2K60.41430659
141RPS6KA20.40898077
142SGK30.40059819
143CSNK1G10.38236793
144PRKCZ0.38019109
145FGFR10.37451097
146DMPK0.36497648
147PRKAA10.34827960
148MAPKAPK50.34704926
149PRKD20.32583162
150RIPK10.32421536
151ADRBK10.31150239

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.27779721
2Nicotine addiction_Homo sapiens_hsa050332.95138166
3Insulin secretion_Homo sapiens_hsa049112.77719619
4Long-term potentiation_Homo sapiens_hsa047202.62043653
5Amphetamine addiction_Homo sapiens_hsa050312.53631899
6Olfactory transduction_Homo sapiens_hsa047402.51395785
7Circadian entrainment_Homo sapiens_hsa047132.49396342
8GABAergic synapse_Homo sapiens_hsa047272.48592915
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.46721037
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37663594
11Phenylalanine metabolism_Homo sapiens_hsa003602.25789079
12Glutamatergic synapse_Homo sapiens_hsa047242.24737666
13Vitamin B6 metabolism_Homo sapiens_hsa007502.23593218
14Dopaminergic synapse_Homo sapiens_hsa047282.22557749
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.22089468
16Morphine addiction_Homo sapiens_hsa050322.16966804
17Histidine metabolism_Homo sapiens_hsa003402.03269379
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.02392910
19Taste transduction_Homo sapiens_hsa047421.99135444
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.88983884
21Cocaine addiction_Homo sapiens_hsa050301.88323737
22Cholinergic synapse_Homo sapiens_hsa047251.88173711
23Salivary secretion_Homo sapiens_hsa049701.87830463
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80401708
25Sphingolipid metabolism_Homo sapiens_hsa006001.75678066
26Collecting duct acid secretion_Homo sapiens_hsa049661.75143404
27Type II diabetes mellitus_Homo sapiens_hsa049301.73577224
28Gastric acid secretion_Homo sapiens_hsa049711.66252673
29Vibrio cholerae infection_Homo sapiens_hsa051101.66023932
30Serotonergic synapse_Homo sapiens_hsa047261.65357442
31Tyrosine metabolism_Homo sapiens_hsa003501.63404938
32Long-term depression_Homo sapiens_hsa047301.57371619
33Renin secretion_Homo sapiens_hsa049241.56897312
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56459854
35beta-Alanine metabolism_Homo sapiens_hsa004101.54907045
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52215268
37Chemical carcinogenesis_Homo sapiens_hsa052041.49875810
38Oxytocin signaling pathway_Homo sapiens_hsa049211.41365669
39Folate biosynthesis_Homo sapiens_hsa007901.40211517
40GnRH signaling pathway_Homo sapiens_hsa049121.39118261
41Glutathione metabolism_Homo sapiens_hsa004801.38669756
42Tight junction_Homo sapiens_hsa045301.35694325
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35612474
44ECM-receptor interaction_Homo sapiens_hsa045121.33356174
45Calcium signaling pathway_Homo sapiens_hsa040201.32664447
46Gap junction_Homo sapiens_hsa045401.30395815
47Estrogen signaling pathway_Homo sapiens_hsa049151.29695361
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28886934
49Type I diabetes mellitus_Homo sapiens_hsa049401.24253700
50Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17537167
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16302002
52Adherens junction_Homo sapiens_hsa045201.13932517
53Pancreatic secretion_Homo sapiens_hsa049721.12974843
54cAMP signaling pathway_Homo sapiens_hsa040241.10589309
55Carbohydrate digestion and absorption_Homo sapiens_hsa049731.09625778
56Glioma_Homo sapiens_hsa052141.04746885
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04403334
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03677423
59Arginine biosynthesis_Homo sapiens_hsa002201.02379085
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01932451
61Glycosaminoglycan degradation_Homo sapiens_hsa005311.01848689
62Thyroid hormone synthesis_Homo sapiens_hsa049181.01467142
63Melanogenesis_Homo sapiens_hsa049161.00376436
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98965451
65Hippo signaling pathway_Homo sapiens_hsa043900.95705842
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.94970973
67Oocyte meiosis_Homo sapiens_hsa041140.94626210
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93731026
69Dorso-ventral axis formation_Homo sapiens_hsa043200.90778739
70Glucagon signaling pathway_Homo sapiens_hsa049220.89401806
71Retinol metabolism_Homo sapiens_hsa008300.88178550
72ABC transporters_Homo sapiens_hsa020100.88027797
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86870067
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84773985
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83837349
76ErbB signaling pathway_Homo sapiens_hsa040120.82768810
77Focal adhesion_Homo sapiens_hsa045100.79310605
78Cardiac muscle contraction_Homo sapiens_hsa042600.78758465
79Arginine and proline metabolism_Homo sapiens_hsa003300.77002870
80Phototransduction_Homo sapiens_hsa047440.74533816
81Proteoglycans in cancer_Homo sapiens_hsa052050.73905341
82Steroid biosynthesis_Homo sapiens_hsa001000.73380759
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73005354
84Axon guidance_Homo sapiens_hsa043600.72906666
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71808625
86Butanoate metabolism_Homo sapiens_hsa006500.71723858
87mTOR signaling pathway_Homo sapiens_hsa041500.69307185
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68353563
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68145984
90Alcoholism_Homo sapiens_hsa050340.68006202
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.67830335
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66138532
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.65761837
94Prion diseases_Homo sapiens_hsa050200.65600146
95Mineral absorption_Homo sapiens_hsa049780.64470136
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63754694
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63753850
98Circadian rhythm_Homo sapiens_hsa047100.63247735
99Complement and coagulation cascades_Homo sapiens_hsa046100.63220513
100Protein digestion and absorption_Homo sapiens_hsa049740.62811068
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62680152
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.60829531
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59092877
104Fatty acid degradation_Homo sapiens_hsa000710.58118459
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57865534
106MAPK signaling pathway_Homo sapiens_hsa040100.56808833
107AMPK signaling pathway_Homo sapiens_hsa041520.56753921
108Hedgehog signaling pathway_Homo sapiens_hsa043400.56558397
109Insulin signaling pathway_Homo sapiens_hsa049100.56555389
110Inositol phosphate metabolism_Homo sapiens_hsa005620.56441214
111Fatty acid biosynthesis_Homo sapiens_hsa000610.55967065
112Fatty acid elongation_Homo sapiens_hsa000620.55549908
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.55494679
114Choline metabolism in cancer_Homo sapiens_hsa052310.54529696
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54288919
116VEGF signaling pathway_Homo sapiens_hsa043700.53262110
117Dilated cardiomyopathy_Homo sapiens_hsa054140.51639223
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51193178
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50484512
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50072722
121Starch and sucrose metabolism_Homo sapiens_hsa005000.48580806
122Alzheimers disease_Homo sapiens_hsa050100.47407972
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46680114
124Peroxisome_Homo sapiens_hsa041460.46298193
125Protein export_Homo sapiens_hsa030600.45503332
126Ras signaling pathway_Homo sapiens_hsa040140.45470769
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45445326
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45357260
129Prolactin signaling pathway_Homo sapiens_hsa049170.45049054
130Amoebiasis_Homo sapiens_hsa051460.44747613
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44450393
132Pentose phosphate pathway_Homo sapiens_hsa000300.43489240
133Endocytosis_Homo sapiens_hsa041440.43328065
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.43077368
135Endometrial cancer_Homo sapiens_hsa052130.43063400
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42376792
137Basal cell carcinoma_Homo sapiens_hsa052170.41951548
138TGF-beta signaling pathway_Homo sapiens_hsa043500.41792890
139Regulation of autophagy_Homo sapiens_hsa041400.40947326
140Rap1 signaling pathway_Homo sapiens_hsa040150.39925699
141Ovarian steroidogenesis_Homo sapiens_hsa049130.38460465
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37786563
143N-Glycan biosynthesis_Homo sapiens_hsa005100.37252382
144Bile secretion_Homo sapiens_hsa049760.36460997
145Wnt signaling pathway_Homo sapiens_hsa043100.36291517
146Lysosome_Homo sapiens_hsa041420.35336395
147Renal cell carcinoma_Homo sapiens_hsa052110.34345687
148Non-small cell lung cancer_Homo sapiens_hsa052230.30984761
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30462434
150Sulfur metabolism_Homo sapiens_hsa009200.28487916
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.25874843
152Oxidative phosphorylation_Homo sapiens_hsa001900.25049677

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