LRP12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in labyrinthine layer morphogenesis (GO:0060670)6.00403399
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.65636586
3positive regulation by organism of defense response of other organism involved in symbiotic interact4.65636586
4modulation by symbiont of host immune response (GO:0052553)4.65636586
5positive regulation by symbiont of host defense response (GO:0052509)4.65636586
6modulation by symbiont of host defense response (GO:0052031)4.65636586
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.65636586
8positive regulation of heat generation (GO:0031652)4.17070220
9regulation of heat generation (GO:0031650)3.96230005
10neutrophil activation involved in immune response (GO:0002283)3.71422132
11negative regulation of mast cell activation (GO:0033004)3.68350365
12macrophage activation involved in immune response (GO:0002281)3.66137294
13regulation of fever generation (GO:0031620)3.63912851
14regulation of vitamin D biosynthetic process (GO:0060556)3.62829043
15negative regulation of axon guidance (GO:1902668)3.61878016
16negative regulation of axon extension involved in axon guidance (GO:0048843)3.56928880
17negative regulation of systemic arterial blood pressure (GO:0003085)3.55032984
18synaptic vesicle maturation (GO:0016188)3.53612416
19negative chemotaxis (GO:0050919)3.50511306
20ganglion development (GO:0061548)3.47885594
21synaptic vesicle exocytosis (GO:0016079)3.45908409
22phagosome maturation (GO:0090382)3.44648011
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.42869855
24substrate-dependent cell migration (GO:0006929)3.41350392
25cell adhesion mediated by integrin (GO:0033627)3.38039744
26presynaptic membrane assembly (GO:0097105)3.36046539
27platelet dense granule organization (GO:0060155)3.30549922
28limb bud formation (GO:0060174)3.30037616
29neuron projection extension involved in neuron projection guidance (GO:1902284)3.26050302
30axon extension involved in axon guidance (GO:0048846)3.26050302
31positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.25856866
32regulation of short-term neuronal synaptic plasticity (GO:0048172)3.24789894
33tryptophan catabolic process (GO:0006569)3.12329153
34indole-containing compound catabolic process (GO:0042436)3.12329153
35indolalkylamine catabolic process (GO:0046218)3.12329153
36proline transport (GO:0015824)3.11556312
37response to host immune response (GO:0052572)3.10310280
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.10310280
39layer formation in cerebral cortex (GO:0021819)3.10286355
40kynurenine metabolic process (GO:0070189)3.08328202
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.01988790
42negative regulation of cell killing (GO:0031342)3.01988790
43presynaptic membrane organization (GO:0097090)2.99853188
44locomotory exploration behavior (GO:0035641)2.99558882
45positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.98597828
46positive regulation of synaptic transmission, GABAergic (GO:0032230)2.98352246
47amine catabolic process (GO:0009310)2.97581712
48cellular biogenic amine catabolic process (GO:0042402)2.97581712
49regulation of action potential (GO:0098900)2.94107792
50negative regulation of nitric-oxide synthase activity (GO:0051001)2.92310127
51clathrin coat assembly (GO:0048268)2.90431590
52negative regulation of lipid storage (GO:0010888)2.90354139
53regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.87690159
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.84546918
55regulation of integrin-mediated signaling pathway (GO:2001044)2.84471834
56response to pheromone (GO:0019236)2.83562608
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83502957
58tryptophan metabolic process (GO:0006568)2.82229221
59pyrimidine nucleobase catabolic process (GO:0006208)2.81086791
60transferrin transport (GO:0033572)2.80675997
61ionotropic glutamate receptor signaling pathway (GO:0035235)2.80344955
62positive regulation of protein autophosphorylation (GO:0031954)2.79741762
63regulation of glutamate receptor signaling pathway (GO:1900449)2.79191841
64response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77860958
65response to host (GO:0075136)2.77860958
66response to host defenses (GO:0052200)2.77860958
67negative regulation of Rho protein signal transduction (GO:0035024)2.77115907
68regulation of interferon-beta biosynthetic process (GO:0045357)2.76894839
69L-amino acid import (GO:0043092)2.75939123
70positive regulation of mast cell activation involved in immune response (GO:0033008)2.75623885
71positive regulation of mast cell degranulation (GO:0043306)2.75623885
72regulation of axon guidance (GO:1902667)2.74921895
73magnesium ion transport (GO:0015693)2.74735978
74negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.73239517
75positive regulation of cardiac muscle cell differentiation (GO:2000727)2.73103479
76positive regulation of cAMP-mediated signaling (GO:0043950)2.72855631
77regulation of synapse structural plasticity (GO:0051823)2.72596825
78microglial cell activation (GO:0001774)2.72581314
79regulation of synaptic vesicle exocytosis (GO:2000300)2.72048153
80neuron cell-cell adhesion (GO:0007158)2.71705737
81behavioral response to nicotine (GO:0035095)2.69902928
82positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.68208820
83regulation of chronic inflammatory response (GO:0002676)2.67971675
84positive regulation of mast cell activation (GO:0033005)2.67654756
85anterior/posterior axis specification, embryo (GO:0008595)2.67631359
86protein localization to synapse (GO:0035418)2.65791718
87dendrite morphogenesis (GO:0048813)2.65040270
88prostate gland growth (GO:0060736)2.65027643
89vocalization behavior (GO:0071625)2.63698416
90indolalkylamine metabolic process (GO:0006586)2.63044321
91cellular potassium ion homeostasis (GO:0030007)2.62743245
92regulation of hippo signaling (GO:0035330)2.61952718
93positive regulation of mitochondrial fission (GO:0090141)2.61896189
94energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.61259460
95ATP hydrolysis coupled proton transport (GO:0015991)2.61259460
96regulation of axon extension involved in axon guidance (GO:0048841)2.60358264
97cellular response to ATP (GO:0071318)2.60120025
98glutamate secretion (GO:0014047)2.59765446
99negative regulation of JAK-STAT cascade (GO:0046426)2.59512014
100negative regulation of interleukin-17 production (GO:0032700)2.59127478
101trivalent inorganic cation transport (GO:0072512)2.58881364
102ferric iron transport (GO:0015682)2.58881364
103myeloid cell activation involved in immune response (GO:0002275)2.58323497
104axonal fasciculation (GO:0007413)2.58117916
105heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.57525266
106peristalsis (GO:0030432)2.55645845
107microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.54948791
108positive regulation of leukocyte degranulation (GO:0043302)2.54683595
109positive regulation of macrophage cytokine production (GO:0060907)2.53991974
110negative regulation of monooxygenase activity (GO:0032769)2.52603386
111regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.51435277
112production of molecular mediator involved in inflammatory response (GO:0002532)2.50845921
113regulation of leukocyte degranulation (GO:0043300)2.50509982
114regulation of regulated secretory pathway (GO:1903305)2.49832171
115dendritic spine morphogenesis (GO:0060997)2.49733607
116respiratory burst (GO:0045730)2.48744783
117regulation of mast cell degranulation (GO:0043304)2.48506678
118neuron recognition (GO:0008038)2.48439191
119amino acid import (GO:0043090)2.46440862
120vesicle transport along microtubule (GO:0047496)2.45723366
121response to lipoprotein particle (GO:0055094)2.45621544
122macrophage activation (GO:0042116)2.44629360
123regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43921091
124activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.42828895
125cerebral cortex cell migration (GO:0021795)2.42738778
126nerve growth factor signaling pathway (GO:0038180)2.42160192
127glycosphingolipid biosynthetic process (GO:0006688)2.42127485
128granulocyte activation (GO:0036230)2.42028339
129cerebral cortex radially oriented cell migration (GO:0021799)2.41902077
130positive regulation of action potential (GO:0045760)2.41042044
131postsynaptic membrane organization (GO:0001941)2.40970208
132regulation of ARF protein signal transduction (GO:0032012)2.40662429
133glutamate receptor signaling pathway (GO:0007215)2.40534717
134regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.40225334
135negative regulation of axon extension (GO:0030517)2.39494308
136positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.39487061
137exploration behavior (GO:0035640)2.39383853
138regulation of long-term neuronal synaptic plasticity (GO:0048169)2.38716336
139sequestering of extracellular ligand from receptor (GO:0035581)2.37454769
140negative regulation of amino acid transport (GO:0051956)2.37305137
141spinal cord development (GO:0021510)2.37175183
142eosinophil chemotaxis (GO:0048245)2.37108966
143regulation of mononuclear cell migration (GO:0071675)2.36389428
144alanine transport (GO:0032328)2.36374207
145neurotransmitter secretion (GO:0007269)2.36049907
146regulation of mast cell activation involved in immune response (GO:0033006)2.35479028
147tachykinin receptor signaling pathway (GO:0007217)2.34230093
148regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.34185736
149regulation of neuronal synaptic plasticity (GO:0048168)2.33985733
150artery development (GO:0060840)2.33024713
151negative regulation of nitric oxide biosynthetic process (GO:0045019)2.32685719
152semaphorin-plexin signaling pathway (GO:0071526)2.32256569
153response to caffeine (GO:0031000)2.32237274
154retinal ganglion cell axon guidance (GO:0031290)2.32070433
155cellular response to nerve growth factor stimulus (GO:1990090)2.30956841
156response to nerve growth factor (GO:1990089)2.30956841
157regulation of axon extension (GO:0030516)2.30916515
158cellular response to vitamin D (GO:0071305)2.30732964
159negative regulation of synaptic transmission, GABAergic (GO:0032229)2.30497622
160gamma-aminobutyric acid transport (GO:0015812)2.30378043
161response to peptidoglycan (GO:0032494)2.30344778
162neuronal action potential propagation (GO:0019227)2.28435056
163regulation of vitamin metabolic process (GO:0030656)2.28137933
164regulation of synaptic transmission, GABAergic (GO:0032228)2.28012410
165sphingosine metabolic process (GO:0006670)2.27993743
166spindle assembly involved in mitosis (GO:0090307)2.27842258
167mating behavior (GO:0007617)2.27723657
168protein localization to endosome (GO:0036010)2.27200501
169lipopolysaccharide-mediated signaling pathway (GO:0031663)2.26698347
170chondrocyte proliferation (GO:0035988)2.26568797
171positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.26356397
172neutrophil chemotaxis (GO:0030593)2.25706037
173G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.25458845
174positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.25398440
175positive regulation of cellular amide metabolic process (GO:0034250)2.25052065
176neural tube formation (GO:0001841)2.24938790
177regulation of extent of cell growth (GO:0061387)2.24837221
178activation of protein kinase A activity (GO:0034199)2.24601927
179gamma-aminobutyric acid signaling pathway (GO:0007214)2.24333794
180positive regulation of muscle hypertrophy (GO:0014742)2.23737212
181positive regulation of cardiac muscle hypertrophy (GO:0010613)2.23737212
182urinary tract smooth muscle contraction (GO:0014848)2.23234089
183behavioral response to ethanol (GO:0048149)2.23198745
184neuromuscular process controlling balance (GO:0050885)2.22784611
185sympathetic nervous system development (GO:0048485)2.22753480
186heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.22679145
187cerebellar Purkinje cell layer development (GO:0021680)2.21869919
188regulation of glutamate secretion (GO:0014048)2.21357603
189positive regulation of chemokine biosynthetic process (GO:0045080)2.21325537
190regulation of synaptic vesicle transport (GO:1902803)2.21179789
191membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.21088092
192regulation of cell proliferation involved in kidney development (GO:1901722)2.20899068
193regulation of membrane protein ectodomain proteolysis (GO:0051043)2.17464780
194regulation of collateral sprouting (GO:0048670)2.17318886
195regulation of telomere maintenance (GO:0032204)2.15522533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.21877127
2EZH2_22144423_ChIP-Seq_EOC_Human3.46237839
3IRF8_21731497_ChIP-ChIP_J774_Mouse2.88759553
4Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.80502294
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63467938
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41811357
7GBX2_23144817_ChIP-Seq_PC3_Human2.29400931
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.26053595
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.22565871
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14476103
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12105124
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05840052
13FUS_26573619_Chip-Seq_HEK293_Human2.03004133
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00799156
15* IRF8_27001747_Chip-Seq_BMDM_Mouse2.00041199
16DROSHA_22980978_ChIP-Seq_HELA_Human1.97343775
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96097272
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95283030
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88179258
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87665139
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87365962
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85664102
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85664102
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80922194
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.80603096
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80410317
27EWS_26573619_Chip-Seq_HEK293_Human1.78928531
28REST_21632747_ChIP-Seq_MESCs_Mouse1.75785549
29VDR_22108803_ChIP-Seq_LS180_Human1.74470500
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73910192
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.73210910
32CJUN_26792858_Chip-Seq_BT549_Human1.73051821
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71952255
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.71577439
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.68588968
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.68097136
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63600557
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.60000006
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58425628
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57560557
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52698612
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.51573024
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.50879527
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48848772
45IGF1R_20145208_ChIP-Seq_DFB_Human1.47454922
46EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46769808
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46381537
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.44224747
49* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.44174263
50* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.44174263
51BRD4_25478319_ChIP-Seq_HGPS_Human1.43772087
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.43474511
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43193485
54AR_21572438_ChIP-Seq_LNCaP_Human1.42520265
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42054200
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41950908
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.40787262
58* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40270273
59P53_22387025_ChIP-Seq_ESCs_Mouse1.39304821
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.38488620
61* VDR_24787735_ChIP-Seq_THP-1_Human1.38204675
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38144049
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.37303486
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.34880663
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33160334
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.32682349
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32533836
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32301776
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31064742
70* TCF4_23295773_ChIP-Seq_U87_Human1.30375833
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30285923
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.29934545
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27783098
74BCAT_22108803_ChIP-Seq_LS180_Human1.27294016
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27276194
76CBP_20019798_ChIP-Seq_JUKART_Human1.27276194
77RXR_22108803_ChIP-Seq_LS180_Human1.26822676
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.26028826
79SPI1_23127762_ChIP-Seq_K562_Human1.25200404
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25074461
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24915704
82EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24472677
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24162743
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22817131
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21375248
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.20873964
87* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20649771
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19714637
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19493645
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.19366047
91JUN_21703547_ChIP-Seq_K562_Human1.19182323
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19153493
93SMAD4_21799915_ChIP-Seq_A2780_Human1.18076320
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17026726
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16583029
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.16103693
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15916944
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.15017083
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14863739
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14863739
101KDM2B_26808549_Chip-Seq_REH_Human1.14520065
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14198149
103AHR_22903824_ChIP-Seq_MCF-7_Human1.13612506
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13525640
105* SMAD4_21741376_ChIP-Seq_EPCs_Human1.13464765
106P300_18555785_Chip-Seq_ESCs_Mouse1.13298057
107* PRDM14_20953172_ChIP-Seq_ESCs_Human1.13109289
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12088064
109* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11507692
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.11226415
111* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10133420
112* TP53_18474530_ChIP-ChIP_U2OS_Human1.09861800
113ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09561671
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08062909
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07915745
116KDM2B_26808549_Chip-Seq_K562_Human1.07909930
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.07846800
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07449786
119CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07039381
120P300_19829295_ChIP-Seq_ESCs_Human1.06861054
121* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06324539
122WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06217163
123TAF15_26573619_Chip-Seq_HEK293_Human1.06066374
124MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06008498
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.05476150
126* RUNX2_22187159_ChIP-Seq_PCA_Human1.05323738
127POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04667475
128NANOG_19829295_ChIP-Seq_ESCs_Human1.04012367
129AR_25329375_ChIP-Seq_VCAP_Human1.03718358
130* SOX2_21211035_ChIP-Seq_LN229_Gbm1.02996693
131BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02771057
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02716346
133PIAS1_25552417_ChIP-Seq_VCAP_Human1.02425684
134* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02068419
135TP53_16413492_ChIP-PET_HCT116_Human1.01316465
136CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01208021
137* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00941112
138* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99617942
139P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99556658
140GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99420651
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99175138
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99098224
143* ER_23166858_ChIP-Seq_MCF-7_Human0.97183019
144STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97108632
145STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95462697
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95270658
147EGR1_19374776_ChIP-ChIP_THP-1_Human0.93565496
148KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90780116
149* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90612213
150STAT3_23295773_ChIP-Seq_U87_Human0.89527510
151* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89152154
152ZNF274_21170338_ChIP-Seq_K562_Hela0.89123699
153PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88028027
154WT1_19549856_ChIP-ChIP_CCG9911_Human0.87564397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.50595726
2MP0006054_spinal_hemorrhage3.64575796
3MP0000569_abnormal_digit_pigmentation3.43492433
4MP0003172_abnormal_lysosome_physiology3.35854987
5MP0005058_abnormal_lysosome_morphology3.34075675
6MP0003303_peritoneal_inflammation3.29300872
7MP0003880_abnormal_central_pattern3.10893936
8MP0004270_analgesia2.79659889
9MP0003635_abnormal_synaptic_transmissio2.67584305
10MP0006082_CNS_inflammation2.54050290
11MP0009046_muscle_twitch2.52116869
12MP0003950_abnormal_plasma_membrane2.49349885
13MP0002102_abnormal_ear_morphology2.45779728
14MP0002064_seizures2.41260309
15MP0003690_abnormal_glial_cell2.36667447
16MP0004510_myositis2.19838572
17MP0000604_amyloidosis2.16897650
18MP0004858_abnormal_nervous_system2.16344815
19MP0002063_abnormal_learning/memory/cond2.16229380
20MP0005367_renal/urinary_system_phenotyp2.14632131
21MP0000516_abnormal_urinary_system2.14632131
22MP0010386_abnormal_urinary_bladder2.13358774
23MP0009745_abnormal_behavioral_response2.10958254
24MP0003183_abnormal_peptide_metabolism2.08117037
25MP0003195_calcinosis2.06684372
26MP0003436_decreased_susceptibility_to2.02928174
27MP0002653_abnormal_ependyma_morphology2.01804743
28MP0003279_aneurysm1.99641181
29MP0000920_abnormal_myelination1.94111678
30MP0002751_abnormal_autonomic_nervous1.88642781
31MP0002837_dystrophic_cardiac_calcinosis1.87698417
32MP0002090_abnormal_vision1.83086469
33MP0002419_abnormal_innate_immunity1.80620077
34MP0002734_abnormal_mechanical_nocicepti1.77184457
35MP0003634_abnormal_glial_cell1.75470229
36MP0002572_abnormal_emotion/affect_behav1.73794729
37MP0002295_abnormal_pulmonary_circulatio1.73644419
38MP0003075_altered_response_to1.71260005
39MP0009384_cardiac_valve_regurgitation1.69843461
40MP0005257_abnormal_intraocular_pressure1.68562807
41MP0005171_absent_coat_pigmentation1.63383885
42MP0001486_abnormal_startle_reflex1.62407583
43MP0009053_abnormal_anal_canal1.62030792
44MP0003329_amyloid_beta_deposits1.58890751
45MP0002735_abnormal_chemical_nociception1.57367146
46MP0005000_abnormal_immune_tolerance1.53085001
47MP0001968_abnormal_touch/_nociception1.51407237
48MP0004811_abnormal_neuron_physiology1.51026010
49MP0001440_abnormal_grooming_behavior1.49712388
50MP0002733_abnormal_thermal_nociception1.44867753
51MP0001542_abnormal_bone_strength1.44378673
52MP0002282_abnormal_trachea_morphology1.44133505
53MP0009780_abnormal_chondrocyte_physiolo1.43964612
54MP0002332_abnormal_exercise_endurance1.43676768
55MP0001501_abnormal_sleep_pattern1.41946091
56MP0000778_abnormal_nervous_system1.41212363
57MP0001849_ear_inflammation1.38541699
58MP0003283_abnormal_digestive_organ1.37372224
59MP0001970_abnormal_pain_threshold1.37001310
60MP0005423_abnormal_somatic_nervous1.34937782
61MP0001835_abnormal_antigen_presentation1.33814203
62MP0002254_reproductive_system_inflammat1.31679146
63MP0001529_abnormal_vocalization1.31540826
64MP0002148_abnormal_hypersensitivity_rea1.31082063
65MP0001299_abnormal_eye_distance/1.30107541
66MP0009764_decreased_sensitivity_to1.29168038
67MP0002272_abnormal_nervous_system1.28460261
68MP0005595_abnormal_vascular_smooth1.26803633
69MP0003633_abnormal_nervous_system1.26236084
70MP0009250_abnormal_appendicular_skeleto1.26032374
71MP0002938_white_spotting1.25670724
72MP0002998_abnormal_bone_remodeling1.25051618
73MP0005084_abnormal_gallbladder_morpholo1.24239687
74MP0008004_abnormal_stomach_pH1.23757103
75MP0005167_abnormal_blood-brain_barrier1.23150621
76MP0003937_abnormal_limbs/digits/tail_de1.21866295
77MP0003755_abnormal_palate_morphology1.21702202
78MP0001533_abnormal_skeleton_physiology1.21413878
79MP0008789_abnormal_olfactory_epithelium1.20824800
80MP0005310_abnormal_salivary_gland1.20558992
81MP0005187_abnormal_penis_morphology1.20299580
82MP0002184_abnormal_innervation1.19931860
83MP0005275_abnormal_skin_tensile1.18841289
84MP0002067_abnormal_sensory_capabilities1.17237356
85MP0002909_abnormal_adrenal_gland1.17230933
86MP0000955_abnormal_spinal_cord1.17153490
87MP0004272_abnormal_basement_membrane1.16190018
88MP0003300_gastrointestinal_ulcer1.14248519
89MP0008569_lethality_at_weaning1.12952084
90MP0005166_decreased_susceptibility_to1.11374488
91MP0001485_abnormal_pinna_reflex1.10308297
92MP0003448_altered_tumor_morphology1.07271360
93MP0002736_abnormal_nociception_after1.06142069
94MP0000749_muscle_degeneration1.06079370
95MP0001879_abnormal_lymphatic_vessel1.05061138
96MP0003385_abnormal_body_wall1.04086497
97MP0003890_abnormal_embryonic-extraembry1.04002735
98MP0000383_abnormal_hair_follicle1.03442098
99MP0002882_abnormal_neuron_morphology1.02489416
100MP0005464_abnormal_platelet_physiology1.01929749
101MP0004742_abnormal_vestibular_system1.01811443
102MP0008260_abnormal_autophagy1.00410936
103MP0004924_abnormal_behavior0.99982035
104MP0005386_behavior/neurological_phenoty0.99982035
105MP0000230_abnormal_systemic_arterial0.99435058
106MP0004215_abnormal_myocardial_fiber0.98570205
107MP0000049_abnormal_middle_ear0.98407394
108MP0002896_abnormal_bone_mineralization0.98141635
109MP0003631_nervous_system_phenotype0.97720726
110MP0005174_abnormal_tail_pigmentation0.97607642
111MP0002452_abnormal_antigen_presenting0.97559400
112MP0002557_abnormal_social/conspecific_i0.97417240
113MP0005623_abnormal_meninges_morphology0.96626576
114MP0002066_abnormal_motor_capabilities/c0.96064933
115MP0006072_abnormal_retinal_apoptosis0.95945384
116MP0005620_abnormal_muscle_contractility0.95878515
117MP0004134_abnormal_chest_morphology0.95660967
118MP0005253_abnormal_eye_physiology0.94888563
119MP0001851_eye_inflammation0.93494271
120MP0005195_abnormal_posterior_eye0.91666427
121MP0000013_abnormal_adipose_tissue0.91219970
122MP0005025_abnormal_response_to0.90654739
123MP0003632_abnormal_nervous_system0.90234874
124MP0004084_abnormal_cardiac_muscle0.89841631
125MP0002233_abnormal_nose_morphology0.86496975
126MP0006276_abnormal_autonomic_nervous0.84935675
127MP0009697_abnormal_copulation0.84896170
128MP0005248_abnormal_Harderian_gland0.83437842
129MP0001502_abnormal_circadian_rhythm0.81203823
130MP0002723_abnormal_immune_serum0.80742601
131MP0002177_abnormal_outer_ear0.79644711
132MP0005508_abnormal_skeleton_morphology0.79547485
133MP0002229_neurodegeneration0.79335314
134MP0009840_abnormal_foam_cell0.79306179
135MP0002234_abnormal_pharynx_morphology0.78329758
136MP0008775_abnormal_heart_ventricle0.77499545
137MP0010352_gastrointestinal_tract_polyps0.77412876
138MP0005646_abnormal_pituitary_gland0.77277792
139MP0000647_abnormal_sebaceous_gland0.76869809
140MP0008877_abnormal_DNA_methylation0.76475687
141MP0005394_taste/olfaction_phenotype0.75616260
142MP0001177_atelectasis0.75551754
143MP0005076_abnormal_cell_differentiation0.75167726
144MP0001819_abnormal_immune_cell0.72053828
145MP0009785_altered_susceptibility_to0.71773461
146MP0004947_skin_inflammation0.70741916
147MP0000015_abnormal_ear_pigmentation0.70262143
148MP0001958_emphysema0.70145279
149MP0003091_abnormal_cell_migration0.69971493
150MP0005387_immune_system_phenotype0.69630915
151MP0001790_abnormal_immune_system0.69630915
152MP0002420_abnormal_adaptive_immunity0.67921474
153MP0008438_abnormal_cutaneous_collagen0.67824386
154MP0005197_abnormal_uvea_morphology0.67374598
155MP0002152_abnormal_brain_morphology0.67337585
156MP0008961_abnormal_basal_metabolism0.67299040
157MP0004885_abnormal_endolymph0.66437665
158MP0003879_abnormal_hair_cell0.66254514
159MP0000343_altered_response_to0.66053554
160MP0010307_abnormal_tumor_latency0.64814361
161MP0001984_abnormal_olfaction0.62651680
162MP0005535_abnormal_body_temperature0.61902410
163MP0005164_abnormal_response_to0.61374331

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.82898747
2Increased neuronal autofluorescent lipopigment (HP:0002074)4.83481150
3Recurrent abscess formation (HP:0002722)4.38391974
4Eczematoid dermatitis (HP:0000976)4.22553648
5Supranuclear gaze palsy (HP:0000605)4.17270700
6Recurrent bacterial skin infections (HP:0005406)3.91032751
7Disinhibition (HP:0000734)3.87227061
8Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.81801757
9Short 1st metacarpal (HP:0010034)3.81801757
10Recurrent gram-negative bacterial infections (HP:0005420)3.70477772
11Abnormality of liposaccharide metabolism (HP:0010968)3.62893693
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.62893693
13Abnormality of glycolipid metabolism (HP:0010969)3.62893693
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.55807500
15Neurofibrillary tangles (HP:0002185)3.52695486
16Focal motor seizures (HP:0011153)3.52507678
17Mutism (HP:0002300)3.45192571
18Abnormality of macrophages (HP:0004311)3.43045474
19Increased corneal curvature (HP:0100692)3.34496261
20Keratoconus (HP:0000563)3.34496261
21Vacuolated lymphocytes (HP:0001922)3.31207302
22Dysostosis multiplex (HP:0000943)3.27531759
23Abnormality of the 1st metacarpal (HP:0010009)3.17893915
24Cerebral inclusion bodies (HP:0100314)3.12600959
25Neuronal loss in central nervous system (HP:0002529)3.11771151
26Inappropriate behavior (HP:0000719)3.09776429
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.07144976
28Focal seizures (HP:0007359)3.00509697
29Apathy (HP:0000741)2.94697228
30Axonal loss (HP:0003447)2.92711973
31Myokymia (HP:0002411)2.82127289
32Disproportionate short-trunk short stature (HP:0003521)2.79221148
33Type II lissencephaly (HP:0007260)2.79103699
34Follicular hyperkeratosis (HP:0007502)2.79098136
35Diminished motivation (HP:0000745)2.78550461
36Molar tooth sign on MRI (HP:0002419)2.76164604
37Abnormality of midbrain morphology (HP:0002418)2.76164604
38Visual hallucinations (HP:0002367)2.73778205
39Delayed gross motor development (HP:0002194)2.71129110
40Ectopic kidney (HP:0000086)2.67960590
41Abnormality of binocular vision (HP:0011514)2.62993606
42Diplopia (HP:0000651)2.62993606
43Mucopolysacchariduria (HP:0008155)2.61149319
44Urinary glycosaminoglycan excretion (HP:0003541)2.61149319
45J-shaped sella turcica (HP:0002680)2.58798256
46Gingivitis (HP:0000230)2.51892541
47Akinesia (HP:0002304)2.51862359
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.50759245
49Abnormality of polysaccharide metabolism (HP:0011012)2.50759245
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.50759245
51Chorioretinal atrophy (HP:0000533)2.50036058
52Pancreatic cysts (HP:0001737)2.49269950
53Pancreatic fibrosis (HP:0100732)2.48247631
54Action tremor (HP:0002345)2.44870341
55Loss of speech (HP:0002371)2.42991335
56Short phalanx of the thumb (HP:0009660)2.42734446
57Fused cervical vertebrae (HP:0002949)2.41298085
58Retinal atrophy (HP:0001105)2.39542398
59Pendular nystagmus (HP:0012043)2.38049692
60Premature rupture of membranes (HP:0001788)2.37360117
61Papilledema (HP:0001085)2.35013224
62Mediastinal lymphadenopathy (HP:0100721)2.34545646
63Nephronophthisis (HP:0000090)2.33921325
64Agitation (HP:0000713)2.33770287
65Atonic seizures (HP:0010819)2.30707231
66Broad ribs (HP:0000885)2.30151878
67Lissencephaly (HP:0001339)2.29275478
68Small hand (HP:0200055)2.28585710
69Hyperventilation (HP:0002883)2.24833784
70True hermaphroditism (HP:0010459)2.21781753
71Absent frontal sinuses (HP:0002688)2.18902490
72Epileptic encephalopathy (HP:0200134)2.18493847
73Recurrent skin infections (HP:0001581)2.17838831
74Gaze-evoked nystagmus (HP:0000640)2.17495236
75Pachygyria (HP:0001302)2.17328619
76Chronic obstructive pulmonary disease (HP:0006510)2.17179162
77Obstructive lung disease (HP:0006536)2.17179162
78Protruding tongue (HP:0010808)2.16643185
79Insidious onset (HP:0003587)2.16241480
80Termporal pattern (HP:0011008)2.16241480
81Absent speech (HP:0001344)2.16044713
82Progressive cerebellar ataxia (HP:0002073)2.14099441
83Clumsiness (HP:0002312)2.13094490
84Dialeptic seizures (HP:0011146)2.10815272
85Aplasia/Hypoplasia of the hallux (HP:0008362)2.10658960
86Metaphyseal irregularity (HP:0003025)2.09672507
87Stomatitis (HP:0010280)2.08508191
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06361410
89Thyroiditis (HP:0100646)2.05734486
90Short hallux (HP:0010109)2.05605711
91Absence seizures (HP:0002121)2.05183963
92Hypoplasia of the odontoid process (HP:0003311)2.01552192
93Generalized tonic-clonic seizures (HP:0002069)2.00780558
94Soft skin (HP:0000977)2.00487373
95Spastic tetraparesis (HP:0001285)2.00113835
96Abnormality of the frontal sinuses (HP:0002687)1.98675332
97Tented upper lip vermilion (HP:0010804)1.98118259
98Abnormality of the renal medulla (HP:0100957)1.96966002
99Abolished electroretinogram (ERG) (HP:0000550)1.96718779
100Hip dysplasia (HP:0001385)1.96602904
101Neoplasm of the oral cavity (HP:0100649)1.96346526
102Hypoplastic iliac wings (HP:0002866)1.95115324
103Urinary bladder sphincter dysfunction (HP:0002839)1.93082311
104Truncal ataxia (HP:0002078)1.91066000
105Arterial tortuosity (HP:0005116)1.91062435
106Febrile seizures (HP:0002373)1.90936849
107Global brain atrophy (HP:0002283)1.90671854
108Progressive inability to walk (HP:0002505)1.90393058
109Vitreoretinal degeneration (HP:0000655)1.90161072
110Peripheral demyelination (HP:0011096)1.89181986
111Abnormality of the odontoid process (HP:0003310)1.88906421
112Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88591500
113Medial flaring of the eyebrow (HP:0010747)1.88115340
114Albinism (HP:0001022)1.86675419
115Macroglossia (HP:0000158)1.85070325
116Macroorchidism (HP:0000053)1.84609675
117Hemiparesis (HP:0001269)1.83866703
118Inability to walk (HP:0002540)1.83630334
119Irregular vertebral endplates (HP:0003301)1.83248817
120Increased CSF protein (HP:0002922)1.82818007
121Choroideremia (HP:0001139)1.82435749
122Chronic hepatic failure (HP:0100626)1.82434626
123Aortic dissection (HP:0002647)1.82259553
124Polyphagia (HP:0002591)1.81141649
125Carpal bone hypoplasia (HP:0001498)1.80575471
126Congenital sensorineural hearing impairment (HP:0008527)1.80234166
127Barrel-shaped chest (HP:0001552)1.79380392
128Depression (HP:0000716)1.78848731
129Abnormal eating behavior (HP:0100738)1.78747195
130Slow saccadic eye movements (HP:0000514)1.78513438
131Esotropia (HP:0000565)1.78447336
132Rapidly progressive (HP:0003678)1.78422926
133Adactyly (HP:0009776)1.77996053
134Lower limb amyotrophy (HP:0007210)1.76723267
135Broad-based gait (HP:0002136)1.76519197
136Agnosia (HP:0010524)1.76340896
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.75610148
138Widely spaced teeth (HP:0000687)1.74158017
139Aplasia/Hypoplasia of the uvula (HP:0010293)1.73434817
140Thick nail (HP:0001805)1.72373400
141Drooling (HP:0002307)1.71809543
142Excessive salivation (HP:0003781)1.71809543
143Abnormality of the parathyroid morphology (HP:0011766)1.71799455
144Dementia (HP:0000726)1.71758575
145Severe muscular hypotonia (HP:0006829)1.71612823
146Retinal dysplasia (HP:0007973)1.71069831
147Abnormality of the corticospinal tract (HP:0002492)1.71024970
148Erythroderma (HP:0001019)1.69222710
149Hematochezia (HP:0002573)1.69128655
150Cerebellar dysplasia (HP:0007033)1.68723451
151Genetic anticipation (HP:0003743)1.67950808
152Stenosis of the external auditory canal (HP:0000402)1.67096153
153Mesomelia (HP:0003027)1.66819805
154Vascular tortuosity (HP:0004948)1.65930965
155Decreased muscle mass (HP:0003199)1.65816511
156Stereotypic behavior (HP:0000733)1.65494162
157Ankle clonus (HP:0011448)1.64768142
158Prostate neoplasm (HP:0100787)1.63868116
159Optic nerve hypoplasia (HP:0000609)1.63842224
160Atrophic scars (HP:0001075)1.63504624
161Spondylolisthesis (HP:0003302)1.63410289
162Abnormality of the carotid arteries (HP:0005344)1.60787801
163Dysmetria (HP:0001310)1.60636022
164Retrobulbar optic neuritis (HP:0100654)1.60607616
165Optic neuritis (HP:0100653)1.60607616
166Postural instability (HP:0002172)1.60281920
167Bladder diverticulum (HP:0000015)1.60203503
168Upper motor neuron abnormality (HP:0002127)1.60149804
169Aplasia/Hypoplasia of the tibia (HP:0005772)1.59835711
170Thoracolumbar scoliosis (HP:0002944)1.59611020
171Dandy-Walker malformation (HP:0001305)1.59475610
172Lower limb muscle weakness (HP:0007340)1.58325159
173Lower limb asymmetry (HP:0100559)1.58110201
174Intention tremor (HP:0002080)1.57754378
175Abnormality of the periventricular white matter (HP:0002518)1.57704748

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.11377102
2ADRBK23.24426317
3FRK3.20436164
4MAP3K92.83551385
5MARK12.63732573
6CASK2.59548166
7NTRK32.53826957
8TNIK2.48719512
9EPHA42.48524737
10TRIM282.41821087
11DAPK22.27413853
12GRK72.20020938
13KSR22.19805190
14PAK62.16960533
15MAP4K22.09375468
16NTRK11.96835863
17BMPR1B1.95768805
18MAPK131.93072961
19GRK11.91505740
20SIK21.90519294
21FES1.87940307
22MINK11.87807290
23EPHB21.78718927
24FGR1.71087799
25WNK31.71010553
26CAMKK11.64547496
27MAP3K131.62384007
28NTRK21.61220580
29BMX1.56701467
30PBK1.56591325
31PINK11.55939874
32MAP3K41.40929581
33ARAF1.37616038
34CDK51.37284784
35ACVR1B1.37192015
36KSR11.35909682
37TBK11.30723702
38STK31.30532047
39MKNK21.28166444
40PLK21.26862041
41DYRK31.24986288
42PNCK1.23660056
43LIMK11.23121544
44TGFBR21.21310322
45RET1.21128297
46EPHB11.19202567
47BRSK21.18731978
48PRKCH1.17664326
49MYLK1.16480221
50CSNK1G31.15230372
51SCYL21.13226537
52MAP3K21.12157713
53CSNK1G11.10623954
54TRIB31.09956066
55LATS21.09869792
56CAMK1G1.09363434
57KIT1.08979570
58STK38L1.06822021
59CAMKK21.05943591
60NUAK11.05427918
61AKT31.04280219
62BLK1.04108142
63MAP3K141.02943681
64ERBB31.00778258
65NEK10.96755673
66PIM20.95298803
67FLT30.94544491
68HCK0.92450484
69ICK0.92391766
70ZAK0.92381188
71TYRO30.90297361
72NEK90.89876403
73PDGFRB0.89038538
74PRKD30.87710558
75FYN0.87659628
76RIPK10.87457665
77FGFR20.87273605
78IRAK20.86482896
79CCNB10.86118577
80UHMK10.82432168
81DDR20.82341286
82IRAK30.81872137
83MKNK10.81323998
84EIF2AK30.81002973
85MAP2K70.80785170
86CSNK1G20.79012413
87SIK30.78963215
88TGFBR10.78766344
89CDK140.78075589
90LATS10.77914317
91PDPK10.76529798
92JAK10.76275006
93IRAK40.76005969
94GRK50.75607472
95PLK30.75322334
96ALK0.75235534
97MOS0.74808297
98MUSK0.74329002
99PDGFRA0.73087967
100BMPR20.71778279
101ADRBK10.70664004
102SYK0.69723437
103CDK180.69224524
104PDK10.68588407
105DAPK10.68464616
106ABL20.68175335
107PRPF4B0.68041412
108PTK2B0.67943850
109CDK150.67791138
110DYRK20.67698984
111MAP3K10.67265726
112EGFR0.66327989
113PRKCE0.66151748
114CAMK1D0.65400097
115PTK60.62491385
116CAMK2D0.60886087
117MATK0.60847476
118PRKCG0.59386241
119ROCK10.59154884
120CAMK2A0.58878180
121BCR0.58535344
122JAK20.58383411
123WNK10.57816056
124RPS6KA20.57784586
125SGK10.56023699
126ERBB40.55915802
127TTN0.55515609
128PAK30.54848531
129CLK10.54143146
130PHKG10.53965894
131PHKG20.53965894
132WEE10.53816596
133CDK11A0.53758146
134MAP2K40.52437371
135PAK20.52063039
136DMPK0.51953248
137INSRR0.51467853
138SRC0.50861531
139HIPK20.50120270
140CAMK2B0.49630618
141PRKCZ0.49221004
142MAP3K120.48724708
143TAOK10.48202789
144PLK40.48066110
145TAF10.47881617
146CSNK1A1L0.47640865
147CHUK0.46389359
148EPHA30.45388788
149GSK3A0.44016446
150STK390.42309277
151ABL10.42213990
152PRKCD0.41988048
153MAP2K10.41933367
154CSF1R0.41546980
155CDC42BPA0.41390279
156MAPK100.40730315
157MARK20.40707111
158PKN10.40443526
159MARK30.38795687
160CSNK1D0.37174657
161IKBKB0.36782037
162CAMK2G0.36226063
163TAOK30.35011647
164CSNK1A10.33832520
165MET0.33633883

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.56872785
2Collecting duct acid secretion_Homo sapiens_hsa049662.25268075
3Lysosome_Homo sapiens_hsa041422.08988758
4Sulfur metabolism_Homo sapiens_hsa009201.98127433
5Rheumatoid arthritis_Homo sapiens_hsa053231.82149220
6Phagosome_Homo sapiens_hsa041451.80792043
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73183941
8ECM-receptor interaction_Homo sapiens_hsa045121.70241797
9Phototransduction_Homo sapiens_hsa047441.69606305
10Vibrio cholerae infection_Homo sapiens_hsa051101.63176706
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.62462431
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59844063
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57786479
14GABAergic synapse_Homo sapiens_hsa047271.57704052
15Nicotine addiction_Homo sapiens_hsa050331.56215669
16Tuberculosis_Homo sapiens_hsa051521.55843863
17Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.55148481
18Osteoclast differentiation_Homo sapiens_hsa043801.51251772
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.49309515
20Morphine addiction_Homo sapiens_hsa050321.46230839
21Protein export_Homo sapiens_hsa030601.45583155
22Leishmaniasis_Homo sapiens_hsa051401.45402584
23Type II diabetes mellitus_Homo sapiens_hsa049301.44606755
24Type I diabetes mellitus_Homo sapiens_hsa049401.44509506
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42042491
26Circadian entrainment_Homo sapiens_hsa047131.38167586
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36419717
28Glutamatergic synapse_Homo sapiens_hsa047241.36386482
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34862069
30Cholinergic synapse_Homo sapiens_hsa047251.34527159
31TGF-beta signaling pathway_Homo sapiens_hsa043501.33573016
32Olfactory transduction_Homo sapiens_hsa047401.33566940
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32269288
34Hippo signaling pathway_Homo sapiens_hsa043901.28141368
35Salmonella infection_Homo sapiens_hsa051321.26716392
36Long-term potentiation_Homo sapiens_hsa047201.26595845
37Selenocompound metabolism_Homo sapiens_hsa004501.25947149
38Dilated cardiomyopathy_Homo sapiens_hsa054141.24186899
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24118700
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21717597
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20442368
42Dopaminergic synapse_Homo sapiens_hsa047281.19916125
43Melanoma_Homo sapiens_hsa052181.17900362
44Basal transcription factors_Homo sapiens_hsa030221.17856653
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13863193
46Insulin secretion_Homo sapiens_hsa049111.11736222
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08907822
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08563483
49Basal cell carcinoma_Homo sapiens_hsa052171.07772537
50Cocaine addiction_Homo sapiens_hsa050301.06709861
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06191094
52Salivary secretion_Homo sapiens_hsa049701.06184767
53Long-term depression_Homo sapiens_hsa047301.05359199
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03112276
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02963579
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01958902
57Pertussis_Homo sapiens_hsa051331.01637056
58Sphingolipid signaling pathway_Homo sapiens_hsa040711.01506494
59Renin secretion_Homo sapiens_hsa049241.00563926
60Chemokine signaling pathway_Homo sapiens_hsa040621.00092306
61Serotonergic synapse_Homo sapiens_hsa047260.99990351
62Glioma_Homo sapiens_hsa052140.99290133
63Amphetamine addiction_Homo sapiens_hsa050310.98289930
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.98125004
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97668673
66Gastric acid secretion_Homo sapiens_hsa049710.97590150
67Steroid biosynthesis_Homo sapiens_hsa001000.97557723
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97210289
69Malaria_Homo sapiens_hsa051440.97110787
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94608593
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93086148
72Oxytocin signaling pathway_Homo sapiens_hsa049210.92392474
73Axon guidance_Homo sapiens_hsa043600.91886728
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91398897
75B cell receptor signaling pathway_Homo sapiens_hsa046620.90974278
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90720345
77Graft-versus-host disease_Homo sapiens_hsa053320.90326052
78Estrogen signaling pathway_Homo sapiens_hsa049150.90051442
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89876974
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89546777
81Hedgehog signaling pathway_Homo sapiens_hsa043400.89199566
82ErbB signaling pathway_Homo sapiens_hsa040120.88691312
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88519889
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.87642126
85TNF signaling pathway_Homo sapiens_hsa046680.84480837
86Endocytosis_Homo sapiens_hsa041440.84479914
87Gap junction_Homo sapiens_hsa045400.84381591
88Dorso-ventral axis formation_Homo sapiens_hsa043200.83837840
89Renal cell carcinoma_Homo sapiens_hsa052110.83320975
90Focal adhesion_Homo sapiens_hsa045100.82896865
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82408042
92GnRH signaling pathway_Homo sapiens_hsa049120.82248424
93VEGF signaling pathway_Homo sapiens_hsa043700.81527606
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80528756
95Shigellosis_Homo sapiens_hsa051310.79118018
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77713517
97Amoebiasis_Homo sapiens_hsa051460.77588025
98Legionellosis_Homo sapiens_hsa051340.74573626
99cAMP signaling pathway_Homo sapiens_hsa040240.73346373
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72719881
101Circadian rhythm_Homo sapiens_hsa047100.72373929
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71633185
103Staphylococcus aureus infection_Homo sapiens_hsa051500.70144329
104Asthma_Homo sapiens_hsa053100.67712171
105Platelet activation_Homo sapiens_hsa046110.67329180
106Chronic myeloid leukemia_Homo sapiens_hsa052200.66561110
107Calcium signaling pathway_Homo sapiens_hsa040200.66099826
108Tryptophan metabolism_Homo sapiens_hsa003800.66094834
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65794937
110African trypanosomiasis_Homo sapiens_hsa051430.65379246
111Ether lipid metabolism_Homo sapiens_hsa005650.65078896
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64919373
113Non-homologous end-joining_Homo sapiens_hsa034500.64833046
114Bladder cancer_Homo sapiens_hsa052190.64791258
115Taste transduction_Homo sapiens_hsa047420.63807569
116MicroRNAs in cancer_Homo sapiens_hsa052060.63253232
117Pancreatic cancer_Homo sapiens_hsa052120.63112733
118MAPK signaling pathway_Homo sapiens_hsa040100.62877889
119Toxoplasmosis_Homo sapiens_hsa051450.62518142
120p53 signaling pathway_Homo sapiens_hsa041150.60955781
121mTOR signaling pathway_Homo sapiens_hsa041500.60792411
122Proteoglycans in cancer_Homo sapiens_hsa052050.60736232
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60344744
124Fanconi anemia pathway_Homo sapiens_hsa034600.60081947
125Choline metabolism in cancer_Homo sapiens_hsa052310.59606434
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59142204
127Other glycan degradation_Homo sapiens_hsa005110.59016887
128Prion diseases_Homo sapiens_hsa050200.58725127
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57928271
130Pathways in cancer_Homo sapiens_hsa052000.57486015
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56968826
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56078382
133Melanogenesis_Homo sapiens_hsa049160.55735736
134Sphingolipid metabolism_Homo sapiens_hsa006000.55414421
135Rap1 signaling pathway_Homo sapiens_hsa040150.55235274
136T cell receptor signaling pathway_Homo sapiens_hsa046600.54465875
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54297478
138NF-kappa B signaling pathway_Homo sapiens_hsa040640.53253147
139Nitrogen metabolism_Homo sapiens_hsa009100.52867241
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51906646
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.50660849
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47530261
143Ras signaling pathway_Homo sapiens_hsa040140.45957080
144Mineral absorption_Homo sapiens_hsa049780.45241027
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44837380
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.44549874

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