LRP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.15093727
2locomotory exploration behavior (GO:0035641)5.13633215
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.94671390
4synaptic vesicle maturation (GO:0016188)4.91827920
5vocalization behavior (GO:0071625)4.79258352
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.63500773
7layer formation in cerebral cortex (GO:0021819)4.59528956
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.55261984
9synaptic vesicle exocytosis (GO:0016079)4.41965484
10glutamate secretion (GO:0014047)4.37831612
11regulation of glutamate receptor signaling pathway (GO:1900449)4.22392000
12neuron cell-cell adhesion (GO:0007158)4.21542481
13protein localization to synapse (GO:0035418)4.16495901
14regulation of synaptic vesicle exocytosis (GO:2000300)4.14907982
15gamma-aminobutyric acid transport (GO:0015812)4.13689520
16neurotransmitter secretion (GO:0007269)4.04111521
17exploration behavior (GO:0035640)3.97028786
18neurotransmitter-gated ion channel clustering (GO:0072578)3.95781329
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.93206156
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.92345506
21dendritic spine morphogenesis (GO:0060997)3.86347226
22regulation of synapse structural plasticity (GO:0051823)3.79184265
23proline transport (GO:0015824)3.77392950
24regulation of synaptic vesicle transport (GO:1902803)3.70727567
25regulation of neuronal synaptic plasticity (GO:0048168)3.69765267
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.66440830
27neuronal action potential propagation (GO:0019227)3.65358069
28cell communication by electrical coupling (GO:0010644)3.58387941
29glutamate receptor signaling pathway (GO:0007215)3.58237185
30neuron recognition (GO:0008038)3.56803314
31alanine transport (GO:0032328)3.55059469
32synaptic transmission, glutamatergic (GO:0035249)3.51742034
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.48422712
34cytoskeletal anchoring at plasma membrane (GO:0007016)3.46163701
35positive regulation of synapse maturation (GO:0090129)3.43225879
36dendrite morphogenesis (GO:0048813)3.41653067
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.41429905
38pyrimidine nucleobase catabolic process (GO:0006208)3.39919495
39axonal fasciculation (GO:0007413)3.39387578
40cell migration in hindbrain (GO:0021535)3.36824393
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34084892
42cellular potassium ion homeostasis (GO:0030007)3.33114121
43sodium ion export (GO:0071436)3.31411023
44regulation of mammary gland epithelial cell proliferation (GO:0033599)3.29660332
45neuron-neuron synaptic transmission (GO:0007270)3.25368584
46activation of protein kinase A activity (GO:0034199)3.21973885
47neurotransmitter transport (GO:0006836)3.21206594
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14249865
49long-term memory (GO:0007616)3.13621925
50positive regulation of synaptic transmission, GABAergic (GO:0032230)3.13002721
51transmission of nerve impulse (GO:0019226)3.08800200
52negative regulation of catenin import into nucleus (GO:0035414)3.07954845
53neuromuscular process controlling balance (GO:0050885)3.07425131
54postsynaptic membrane organization (GO:0001941)3.05820752
55regulation of dendritic spine morphogenesis (GO:0061001)3.05609020
56positive regulation of membrane potential (GO:0045838)3.04979391
57cerebellar Purkinje cell differentiation (GO:0021702)3.04623039
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.04369405
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.03484901
60regulation of neurotransmitter levels (GO:0001505)3.01888866
61auditory behavior (GO:0031223)3.00474763
62innervation (GO:0060384)2.93921135
63regulation of postsynaptic membrane potential (GO:0060078)2.93414140
64amino acid import (GO:0043090)2.92663969
65planar cell polarity pathway involved in neural tube closure (GO:0090179)2.91014980
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88649689
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88384002
68prepulse inhibition (GO:0060134)2.88131919
69nucleobase catabolic process (GO:0046113)2.87815193
70regulation of synaptic plasticity (GO:0048167)2.85977892
71cell-cell junction maintenance (GO:0045217)2.85938067
72protein retention in ER lumen (GO:0006621)2.85586705
73response to auditory stimulus (GO:0010996)2.85222712
74regulation of synaptic transmission, glutamatergic (GO:0051966)2.84400616
75synaptic vesicle endocytosis (GO:0048488)2.82976963
76dopamine receptor signaling pathway (GO:0007212)2.82929364
77neuromuscular process controlling posture (GO:0050884)2.82366621
78glycine transport (GO:0015816)2.81227988
79central nervous system projection neuron axonogenesis (GO:0021952)2.80755325
80regulation of ARF protein signal transduction (GO:0032012)2.80436217
81positive regulation of dendritic spine development (GO:0060999)2.79462685
82neuronal ion channel clustering (GO:0045161)2.79441950
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.79251259
84synapse assembly (GO:0007416)2.78860288
85cerebellar granule cell differentiation (GO:0021707)2.77877842
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77870771
87cerebellar Purkinje cell layer development (GO:0021680)2.77680428
88regulation of neurotransmitter secretion (GO:0046928)2.77205438
89L-amino acid import (GO:0043092)2.76625197
90establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.76528293
91mitochondrion transport along microtubule (GO:0047497)2.76528293
92negative regulation of cell size (GO:0045792)2.75984155
93membrane depolarization during action potential (GO:0086010)2.73108059
94positive regulation of dendrite development (GO:1900006)2.72806492
95protein targeting to plasma membrane (GO:0072661)2.72721675
96establishment of mitochondrion localization (GO:0051654)2.72405790
97cellular sodium ion homeostasis (GO:0006883)2.72391115
98adherens junction assembly (GO:0034333)2.72246665
99regulation of vesicle fusion (GO:0031338)2.71243652
100regulation of glycogen (starch) synthase activity (GO:2000465)2.69402384
101negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69276684
102G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.67655159
103response to dietary excess (GO:0002021)2.67046175
104synapse organization (GO:0050808)2.66368623
105regulation of synapse maturation (GO:0090128)2.66324914
106gamma-aminobutyric acid signaling pathway (GO:0007214)2.66201140
107presynaptic membrane assembly (GO:0097105)2.65965643
108membrane hyperpolarization (GO:0060081)2.63840772
109mating behavior (GO:0007617)2.62411931
110positive regulation of dendritic spine morphogenesis (GO:0061003)2.62382525
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.62020907
112positive regulation of neurotransmitter transport (GO:0051590)2.60934270
113intraspecies interaction between organisms (GO:0051703)2.60499122
114social behavior (GO:0035176)2.60499122
115skeletal muscle organ development (GO:0060538)2.60233252
116membrane depolarization (GO:0051899)2.59693156
117regulation of female receptivity (GO:0045924)2.58360224
118neuromuscular process (GO:0050905)2.58074944
119axon extension (GO:0048675)2.57445866
120regulation of early endosome to late endosome transport (GO:2000641)2.57215305
121dendritic spine organization (GO:0097061)2.56457092
122regulation of dendritic spine development (GO:0060998)2.56007429
123regulation of neurotransmitter transport (GO:0051588)2.55278742
124regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.54332817
125regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53981538
126positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.53307009
127regulation of cholesterol biosynthetic process (GO:0045540)2.50129568
128regulation of fatty acid beta-oxidation (GO:0031998)2.49025069
129regulation of voltage-gated calcium channel activity (GO:1901385)2.47695007
130negative regulation of fatty acid transport (GO:2000192)2.47631921
131neuron projection regeneration (GO:0031102)2.45517336
132neuron projection extension (GO:1990138)2.42027455
133protein localization to endosome (GO:0036010)2.40154565
134respiratory system process (GO:0003016)2.38904334
135positive regulation of neurotransmitter secretion (GO:0001956)2.38155971
136cellular response to monoamine stimulus (GO:0071868)2.37893367
137cellular response to catecholamine stimulus (GO:0071870)2.37893367
138negative regulation of microtubule polymerization (GO:0031115)2.37640355
139myelination in peripheral nervous system (GO:0022011)2.37512143
140peripheral nervous system axon ensheathment (GO:0032292)2.37512143
141axon ensheathment in central nervous system (GO:0032291)2.34565328
142central nervous system myelination (GO:0022010)2.34565328
143maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.33897267
144dicarboxylic acid transport (GO:0006835)2.31009093
145regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.30351960
146protein heterotrimerization (GO:0070208)2.30259895
147tooth mineralization (GO:0034505)2.28572642
148negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.27743272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29223366
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01742313
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00226749
4GBX2_23144817_ChIP-Seq_PC3_Human2.98846172
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97961792
6LXR_22292898_ChIP-Seq_THP-1_Human2.92115464
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.86049545
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76612990
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76612990
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67942194
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.59040189
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56244684
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.51527364
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48820841
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48558025
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47804086
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45195847
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.44265274
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40860641
20DROSHA_22980978_ChIP-Seq_HELA_Human2.38745288
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.33534552
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.32053016
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24926848
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24415428
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.21578782
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20100168
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.18771183
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09687213
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.08361021
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99882802
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97291111
32VDR_21846776_ChIP-Seq_THP-1_Human1.94155414
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91766009
34RACK7_27058665_Chip-Seq_MCF-7_Human1.90401870
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.88460277
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.83479117
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.82742665
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81940688
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81655661
40* KDM2B_26808549_Chip-Seq_DND41_Human1.81025788
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80522571
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78305565
43P68_20966046_ChIP-Seq_HELA_Human1.77268320
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.76568156
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.70898000
46AR_21572438_ChIP-Seq_LNCaP_Human1.66812781
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64868826
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.64597538
49SMC4_20622854_ChIP-Seq_HELA_Human1.62679831
50UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.60470965
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60152574
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.58039354
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51960593
54CREB1_26743006_Chip-Seq_LNCaP_Human1.51829662
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.46284015
56SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45086233
57ZNF274_21170338_ChIP-Seq_K562_Hela1.41709095
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41419030
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40852220
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40344778
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40039967
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.39044824
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37190121
64SMAD4_21799915_ChIP-Seq_A2780_Human1.36647346
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35608501
66TCF7_22412390_ChIP-Seq_EML_Mouse1.35257988
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.35253977
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.34542983
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31654676
70TRIM28_21343339_ChIP-Seq_HEK293_Human1.29969747
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29013281
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28474592
73ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28369990
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28181251
75MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27595779
76TAF15_26573619_Chip-Seq_HEK293_Human1.27510539
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.25639741
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.25414478
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24907197
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23130957
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22847039
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22547507
83AR_19668381_ChIP-Seq_PC3_Human1.22481025
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22273002
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21664666
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21027136
87SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20952081
88* KDM2B_26808549_Chip-Seq_K562_Human1.20592289
89* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19611209
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18002624
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17036219
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15804346
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15664028
94ZNF263_19887448_ChIP-Seq_K562_Human1.15424058
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14957153
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14809578
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.12950037
98* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11175498
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.11041258
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09481098
101P300_19829295_ChIP-Seq_ESCs_Human1.09149453
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08417935
103AR_25329375_ChIP-Seq_VCAP_Human1.08278115
104ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07284979
105STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.06743376
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05483490
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04983335
108* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04721421
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03534020
110CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03425171
111STAT3_23295773_ChIP-Seq_U87_Human1.02892304
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02308032
113* ELF1_20517297_ChIP-Seq_JURKAT_Human1.01257719
114TP53_20018659_ChIP-ChIP_R1E_Mouse1.00650611
115MYC_22102868_ChIP-Seq_BL_Human1.00281765
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00135565
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00038026
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00013884
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.99972620
120CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99881072
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99725473
122SOX3_22085726_ChIP-Seq_NPCs_Mouse0.99508748
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99370954
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98864248
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98411600
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.98141055
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97559521
128YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97192987
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96691312
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95923186
131CTCF_27219007_Chip-Seq_Bcells_Human0.95652690
132AHR_22903824_ChIP-Seq_MCF-7_Human0.95351188
133IGF1R_20145208_ChIP-Seq_DFB_Human0.95298240
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93628275
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91019466
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90482201
137ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88954767
138P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87918140
139TCF4_23295773_ChIP-Seq_U87_Human0.87164014
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86558171
141RUNX2_22187159_ChIP-Seq_PCA_Human0.86364059
142SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86016628
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.85793321
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84828466
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84072009
146TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83312465
147POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83312465
148* TET1_21490601_ChIP-Seq_MESCs_Mouse0.82929822
149RNF2_27304074_Chip-Seq_NSC_Mouse0.82496393
150DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82197776
151NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.81549124
152SMAD3_21741376_ChIP-Seq_HESCs_Human0.81327444
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80834529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.55634352
2MP0003880_abnormal_central_pattern3.85584891
3MP0003635_abnormal_synaptic_transmissio3.70455429
4MP0003705_abnormal_hypodermis_morpholog3.65656787
5MP0004270_analgesia3.51090735
6MP0002063_abnormal_learning/memory/cond2.95397142
7MP0009745_abnormal_behavioral_response2.91826885
8MP0002249_abnormal_larynx_morphology2.72789414
9MP0005423_abnormal_somatic_nervous2.68400960
10MP0002064_seizures2.67673767
11MP0009046_muscle_twitch2.59862554
12MP0001968_abnormal_touch/_nociception2.56220811
13MP0009780_abnormal_chondrocyte_physiolo2.46572706
14MP0002734_abnormal_mechanical_nocicepti2.42511574
15MP0002572_abnormal_emotion/affect_behav2.39685181
16MP0001486_abnormal_startle_reflex2.33147380
17MP0002272_abnormal_nervous_system2.16483142
18MP0004185_abnormal_adipocyte_glucose2.15614060
19MP0002822_catalepsy2.12522366
20MP0000778_abnormal_nervous_system2.04894456
21MP0004858_abnormal_nervous_system2.04533286
22MP0005623_abnormal_meninges_morphology1.97403350
23MP0002733_abnormal_thermal_nociception1.97311455
24MP0003329_amyloid_beta_deposits1.96773163
25MP0002909_abnormal_adrenal_gland1.95575112
26MP0006276_abnormal_autonomic_nervous1.93285262
27MP0002736_abnormal_nociception_after1.92425122
28MP0002735_abnormal_chemical_nociception1.89305262
29MP0001440_abnormal_grooming_behavior1.88200288
30MP0001501_abnormal_sleep_pattern1.86959551
31MP0003123_paternal_imprinting1.84549902
32MP0000566_synostosis1.83878172
33MP0002067_abnormal_sensory_capabilities1.78197621
34MP0002184_abnormal_innervation1.76938394
35MP0005058_abnormal_lysosome_morphology1.72263069
36MP0002557_abnormal_social/conspecific_i1.70399527
37MP0001970_abnormal_pain_threshold1.67540283
38MP0005666_abnormal_adipose_tissue1.64669487
39MP0000955_abnormal_spinal_cord1.63898121
40MP0005670_abnormal_white_adipose1.61002189
41MP0000537_abnormal_urethra_morphology1.59209004
42MP0008569_lethality_at_weaning1.58586314
43MP0008438_abnormal_cutaneous_collagen1.57577188
44MP0004885_abnormal_endolymph1.57302229
45MP0004924_abnormal_behavior1.56699420
46MP0005386_behavior/neurological_phenoty1.56699420
47MP0004811_abnormal_neuron_physiology1.56458807
48MP0005646_abnormal_pituitary_gland1.44967020
49MP0002837_dystrophic_cardiac_calcinosis1.44779245
50MP0009379_abnormal_foot_pigmentation1.44272441
51MP0005409_darkened_coat_color1.43015331
52MP0005645_abnormal_hypothalamus_physiol1.42719648
53MP0005375_adipose_tissue_phenotype1.40731813
54MP0001346_abnormal_lacrimal_gland1.39393647
55MP0003122_maternal_imprinting1.37472491
56MP0000003_abnormal_adipose_tissue1.37035640
57MP0010030_abnormal_orbit_morphology1.36914826
58MP0002882_abnormal_neuron_morphology1.36160058
59MP0003283_abnormal_digestive_organ1.35705828
60MP0001984_abnormal_olfaction1.33770901
61MP0002066_abnormal_motor_capabilities/c1.32004468
62MP0003633_abnormal_nervous_system1.28117140
63MP0005076_abnormal_cell_differentiation1.26622799
64MP0001502_abnormal_circadian_rhythm1.24899613
65MP0000534_abnormal_ureter_morphology1.23539802
66MP0005503_abnormal_tendon_morphology1.22842080
67MP0003879_abnormal_hair_cell1.22290285
68MP0002139_abnormal_hepatobiliary_system1.20017891
69MP0000751_myopathy1.19701828
70MP0001849_ear_inflammation1.17484733
71MP0002089_abnormal_postnatal_growth/wei1.17420480
72MP0000678_abnormal_parathyroid_gland1.17149916
73MP0003279_aneurysm1.16307554
74MP0000747_muscle_weakness1.16147822
75MP0002152_abnormal_brain_morphology1.15668140
76MP0003942_abnormal_urinary_system1.15188416
77MP0003690_abnormal_glial_cell1.13429248
78MP0001958_emphysema1.13396499
79MP0000013_abnormal_adipose_tissue1.12247532
80MP0000681_abnormal_thyroid_gland1.08591268
81MP0000733_abnormal_muscle_development1.07752080
82MP0004142_abnormal_muscle_tone1.07030756
83MP0003631_nervous_system_phenotype1.04715790
84MP0002069_abnormal_eating/drinking_beha1.04619463
85MP0001529_abnormal_vocalization1.04541010
86MP0008961_abnormal_basal_metabolism1.04030986
87MP0003787_abnormal_imprinting1.02509642
88MP0005535_abnormal_body_temperature0.99819698
89MP0000049_abnormal_middle_ear0.97876965
90MP0000920_abnormal_myelination0.97226464
91MP0009053_abnormal_anal_canal0.96335977
92MP0009672_abnormal_birth_weight0.95648903
93MP0004145_abnormal_muscle_electrophysio0.94702604
94MP0004130_abnormal_muscle_cell0.94581875
95MP0000759_abnormal_skeletal_muscle0.92092174
96MP0004085_abnormal_heartbeat0.91615216
97MP0000631_abnormal_neuroendocrine_gland0.90786522
98MP0005187_abnormal_penis_morphology0.90234264
99MP0001177_atelectasis0.89829800
100MP0003137_abnormal_impulse_conducting0.88659744
101MP0000604_amyloidosis0.88336981
102MP0005551_abnormal_eye_electrophysiolog0.86916879
103MP0003634_abnormal_glial_cell0.86549614
104MP0001905_abnormal_dopamine_level0.86165183
105MP0005360_urolithiasis0.84279628
106MP0003938_abnormal_ear_development0.82865410
107MP0002229_neurodegeneration0.82233274
108MP0003172_abnormal_lysosome_physiology0.81629899
109MP0000462_abnormal_digestive_system0.81433857
110MP0005451_abnormal_body_composition0.81108421
111MP0001299_abnormal_eye_distance/0.80672616
112MP0010329_abnormal_lipoprotein_level0.80509068
113MP0002116_abnormal_craniofacial_bone0.79593266
114MP0005508_abnormal_skeleton_morphology0.79115607
115MP0008260_abnormal_autophagy0.79055226
116MP0005085_abnormal_gallbladder_physiolo0.78647303
117MP0001348_abnormal_lacrimal_gland0.78630924
118MP0002638_abnormal_pupillary_reflex0.78625563
119MP0004215_abnormal_myocardial_fiber0.76813386
120MP0003632_abnormal_nervous_system0.76412914
121MP0000569_abnormal_digit_pigmentation0.76363480
122MP0005248_abnormal_Harderian_gland0.76363449
123MP0009250_abnormal_appendicular_skeleto0.76066605
124MP0005394_taste/olfaction_phenotype0.75865434
125MP0005499_abnormal_olfactory_system0.75865434
126MP0002752_abnormal_somatic_nervous0.75454461
127MP0005365_abnormal_bile_salt0.75061325
128MP0002876_abnormal_thyroid_physiology0.73906615
129MP0008872_abnormal_physiological_respon0.73069470
130MP0002090_abnormal_vision0.72618339
131MP0009840_abnormal_foam_cell0.72331095
132MP0002971_abnormal_brown_adipose0.71801798
133MP0002108_abnormal_muscle_morphology0.71274598
134MP0001963_abnormal_hearing_physiology0.70486175
135MP0003861_abnormal_nervous_system0.70035910
136MP0008874_decreased_physiological_sensi0.69335396
137MP0005257_abnormal_intraocular_pressure0.68413163
138MP0002114_abnormal_axial_skeleton0.67390402
139MP0010386_abnormal_urinary_bladder0.65890096
140MP0002234_abnormal_pharynx_morphology0.65525539
141MP0001188_hyperpigmentation0.62416333
142MP0004742_abnormal_vestibular_system0.61812271
143MP0004043_abnormal_pH_regulation0.60867675
144MP0004233_abnormal_muscle_weight0.60579484
145MP0003075_altered_response_to0.59643002
146MP0006072_abnormal_retinal_apoptosis0.57165168
147MP0008875_abnormal_xenobiotic_pharmacok0.56716426
148MP0002078_abnormal_glucose_homeostasis0.56236812

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.62193968
2Myokymia (HP:0002411)5.43838767
3Focal seizures (HP:0007359)4.56684915
4Visual hallucinations (HP:0002367)4.21697357
5Epileptic encephalopathy (HP:0200134)3.88616227
6Progressive cerebellar ataxia (HP:0002073)3.48540620
7Atonic seizures (HP:0010819)3.48405508
8Action tremor (HP:0002345)3.47216547
9Supranuclear gaze palsy (HP:0000605)3.46695445
10Generalized tonic-clonic seizures (HP:0002069)3.26236573
11Absence seizures (HP:0002121)3.24414514
12Febrile seizures (HP:0002373)3.22869343
13Hyperacusis (HP:0010780)3.19724032
14Ankle clonus (HP:0011448)3.00215936
15Poor eye contact (HP:0000817)2.99839536
16Shallow orbits (HP:0000586)2.98982581
17Megalencephaly (HP:0001355)2.97345172
18Neurofibrillary tangles (HP:0002185)2.96467645
19Hyperventilation (HP:0002883)2.94476303
20Abnormality of the lower motor neuron (HP:0002366)2.94295200
21Impaired vibration sensation in the lower limbs (HP:0002166)2.94173545
22Impaired social interactions (HP:0000735)2.93035044
23Abnormal social behavior (HP:0012433)2.93035044
24Cerebral inclusion bodies (HP:0100314)2.90845123
25Dialeptic seizures (HP:0011146)2.88081287
26Hemiparesis (HP:0001269)2.86429776
27Ulnar bowing (HP:0003031)2.85564612
28Protrusio acetabuli (HP:0003179)2.82625473
29Abnormal eating behavior (HP:0100738)2.80932676
30Annular pancreas (HP:0001734)2.79613596
31Depression (HP:0000716)2.77998131
32Dysdiadochokinesis (HP:0002075)2.69957356
33Broad-based gait (HP:0002136)2.68999000
34Cerebral aneurysm (HP:0004944)2.65416710
35Epileptiform EEG discharges (HP:0011182)2.64398099
36EEG with generalized epileptiform discharges (HP:0011198)2.63772483
37Status epilepticus (HP:0002133)2.62527597
38Torticollis (HP:0000473)2.61382879
39Anxiety (HP:0000739)2.60971596
40Postural instability (HP:0002172)2.60510431
41Drooling (HP:0002307)2.59768352
42Excessive salivation (HP:0003781)2.59768352
43Hypsarrhythmia (HP:0002521)2.58701722
44Hemiplegia (HP:0002301)2.58101043
45Urinary bladder sphincter dysfunction (HP:0002839)2.57701924
46Amblyopia (HP:0000646)2.49340551
47Increased variability in muscle fiber diameter (HP:0003557)2.47896891
48Achilles tendon contracture (HP:0001771)2.47541288
49Insidious onset (HP:0003587)2.46862991
50Termporal pattern (HP:0011008)2.46862991
51Stridor (HP:0010307)2.46231429
52Focal dystonia (HP:0004373)2.43851098
53Insomnia (HP:0100785)2.43248604
54Agitation (HP:0000713)2.41323887
55Dysmetria (HP:0001310)2.39506174
56Broad distal phalanx of finger (HP:0009836)2.38301821
57Pheochromocytoma (HP:0002666)2.36403786
58Truncal ataxia (HP:0002078)2.34126430
59Genetic anticipation (HP:0003743)2.32995685
60Abnormality of the Achilles tendon (HP:0005109)2.31633691
61Spastic gait (HP:0002064)2.29644753
62Mutism (HP:0002300)2.29288343
63Abnormality of the aortic arch (HP:0012303)2.27854047
64Urinary urgency (HP:0000012)2.26080059
65Craniofacial dystonia (HP:0012179)2.25941770
66Polyphagia (HP:0002591)2.25466784
67Abnormality of the corticospinal tract (HP:0002492)2.23675333
68Intention tremor (HP:0002080)2.23626928
69Partial duplication of the phalanx of hand (HP:0009999)2.20803767
70Gaze-evoked nystagmus (HP:0000640)2.19894065
71Lower limb amyotrophy (HP:0007210)2.18270980
72Premature rupture of membranes (HP:0001788)2.17939367
73Mitral regurgitation (HP:0001653)2.16592550
74Partial duplication of thumb phalanx (HP:0009944)2.14709291
75Aplasia involving bones of the extremities (HP:0009825)2.14677777
76Aplasia involving bones of the upper limbs (HP:0009823)2.14677777
77Aplasia of the phalanges of the hand (HP:0009802)2.14677777
78Vertebral compression fractures (HP:0002953)2.11872647
79Bradykinesia (HP:0002067)2.10117981
80Hepatoblastoma (HP:0002884)2.09258806
81Lower limb muscle weakness (HP:0007340)2.08513963
82Lymphangioma (HP:0100764)2.07616699
83Limb dystonia (HP:0002451)2.07142225
84Broad metatarsal (HP:0001783)2.05694193
85Scanning speech (HP:0002168)2.03554743
86Amyotrophic lateral sclerosis (HP:0007354)2.03441224
87Bronchomalacia (HP:0002780)2.03080785
88Spinal rigidity (HP:0003306)2.00393837
89Abnormality of skeletal muscle fiber size (HP:0012084)2.00182027
90Abnormality of binocular vision (HP:0011514)1.98574765
91Diplopia (HP:0000651)1.98574765
92Papilledema (HP:0001085)1.97881125
93Genu recurvatum (HP:0002816)1.97749882
94Truncus arteriosus (HP:0001660)1.97024933
95Turricephaly (HP:0000262)1.94214719
96Stereotypic behavior (HP:0000733)1.93925785
97Neuroendocrine neoplasm (HP:0100634)1.93889703
98Spinal cord compression (HP:0002176)1.92529332
99Ventricular fibrillation (HP:0001663)1.90534879
100Type 1 muscle fiber predominance (HP:0003803)1.90195676
101Sleep apnea (HP:0010535)1.89894486
102Ketoacidosis (HP:0001993)1.88489502
103Hypercortisolism (HP:0001578)1.88288571
104Hyperparathyroidism (HP:0000843)1.87343000
105Coronal craniosynostosis (HP:0004440)1.87275253
106Impaired vibratory sensation (HP:0002495)1.86939900
107Impaired smooth pursuit (HP:0007772)1.86708015
108Hypoventilation (HP:0002791)1.86380106
109Pointed chin (HP:0000307)1.84536874
110Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.84531901
111Clonus (HP:0002169)1.84282686
112Morphological abnormality of the pyramidal tract (HP:0002062)1.82513360
113Precocious puberty (HP:0000826)1.82383348
114Neoplasm of the heart (HP:0100544)1.80767115
115Disproportionate tall stature (HP:0001519)1.80507620
116Abnormal ventriculo-arterial connection (HP:0011563)1.80404689
117Transposition of the great arteries (HP:0001669)1.80404689
118Abnormal connection of the cardiac segments (HP:0011545)1.80404689
119Spinal canal stenosis (HP:0003416)1.79538766
120Absent speech (HP:0001344)1.79064768
121Akinesia (HP:0002304)1.78567842
122Obstructive sleep apnea (HP:0002870)1.78270746
123Generalized myoclonic seizures (HP:0002123)1.77608958
124Elfin facies (HP:0004428)1.77603794
125Bladder diverticulum (HP:0000015)1.77133763
126Distal lower limb amyotrophy (HP:0008944)1.77129457
127Abnormality of the phalanges of the hallux (HP:0010057)1.76851583
128Germ cell neoplasia (HP:0100728)1.76502698
129Overriding aorta (HP:0002623)1.75016904
130Athetosis (HP:0002305)1.74515020
131Axonal loss (HP:0003447)1.74187308
132Hypercalcemia (HP:0003072)1.74053303
133Upper limb amyotrophy (HP:0009129)1.73842865
134Distal upper limb amyotrophy (HP:0007149)1.73842865
135Double outlet right ventricle (HP:0001719)1.73709109
136Congenital malformation of the right heart (HP:0011723)1.73709109
137Postural tremor (HP:0002174)1.73618205
138Arnold-Chiari malformation (HP:0002308)1.73399890
139Progressive inability to walk (HP:0002505)1.73327836
140Deep venous thrombosis (HP:0002625)1.71624510
141Blue irides (HP:0000635)1.71249852
142Hyperthyroidism (HP:0000836)1.70720216
143Apathy (HP:0000741)1.70564539
144Myopathic facies (HP:0002058)1.70209281
145Biconcave vertebral bodies (HP:0004586)1.69613958
146Increased connective tissue (HP:0009025)1.69125398
147Buphthalmos (HP:0000557)1.68735301
148Long palpebral fissure (HP:0000637)1.68529973
149Congenital glaucoma (HP:0001087)1.68078936
150Lower limb asymmetry (HP:0100559)1.67228483
151Thin bony cortex (HP:0002753)1.67180126
152Hyperextensible skin (HP:0000974)1.66668638
153Ankle contracture (HP:0006466)1.66326150
154Premature skin wrinkling (HP:0100678)1.66114515
155Renovascular hypertension (HP:0100817)1.65670645
156Abnormality of ocular smooth pursuit (HP:0000617)1.64450698
157Choanal stenosis (HP:0000452)1.62649504
158Gait ataxia (HP:0002066)1.62471586
159Bowel diverticulosis (HP:0005222)1.62164239
160Ketosis (HP:0001946)1.62083482
161Asymmetry of the thorax (HP:0001555)1.62035140
162Dysmetric saccades (HP:0000641)1.61826167
163Neuronal loss in central nervous system (HP:0002529)1.61790999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.03904002
2NTRK33.81726287
3EPHA43.57530317
4MAP3K93.34881349
5EEF2K2.82017044
6MAP3K42.80589510
7MINK12.55575260
8SMG12.45713766
9DAPK22.37647906
10NTRK22.35684592
11PRKD32.30185505
12PAK62.13172163
13MAP2K72.08010480
14MAP2K41.97589574
15NTRK11.91260888
16PKN21.82646581
17CASK1.81951685
18PHKG21.79503304
19PHKG11.79503304
20KSR21.70583526
21MAPK131.65773029
22KSR11.65288730
23CAMKK11.61355638
24LATS21.60015081
25IRAK31.59026019
26TNIK1.50838103
27SIK21.48336681
28CDK51.47616091
29MAP3K111.44788116
30UHMK11.32471262
31RIPK11.28160096
32TYRO31.25600640
33TESK11.25333469
34PRKCG1.23762147
35STK381.17761732
36LMTK21.17742358
37NME21.15511722
38GRK51.11750207
39CAMK1G1.09231667
40PNCK1.08075218
41DAPK11.07059812
42BRAF1.06628031
43TTN1.03574845
44IRAK21.01548774
45SGK4941.00978776
46SGK2231.00978776
47RET0.99326123
48TRIB30.97496449
49MAP3K20.96889178
50PLK20.96184197
51TAOK10.93839500
52ILK0.93223520
53DAPK30.92718804
54PAK30.92260369
55PRKCH0.92001469
56CSNK1G20.90455423
57FGFR20.90023582
58INSRR0.89609475
59STK110.88774201
60CDK150.85325971
61CDK180.85301532
62TAOK20.84979352
63MAP3K120.84454305
64CDK140.83259501
65CAMK2A0.81917852
66ABL20.81141849
67SGK20.79680854
68MARK20.78193085
69MTOR0.76842689
70PDGFRA0.75598815
71DYRK1A0.75339958
72PRKCZ0.74489313
73WNK30.74369201
74FES0.74164733
75SGK30.74139516
76CAMKK20.73609977
77CDK11A0.73408682
78ERN10.72285219
79PINK10.71709139
80MAP2K30.70036064
81PRPF4B0.69732546
82PRKD20.69099057
83ICK0.68910760
84CAMK10.68435697
85EPHB20.66395426
86RPS6KL10.65689919
87RPS6KC10.65689919
88CDC42BPA0.64445175
89FER0.62702687
90BRSK10.62626628
91RIPK40.61889053
92CAMK2B0.61327554
93FGFR40.61064181
94SGK10.60627000
95PTK20.60489363
96ALK0.59040763
97ARAF0.58307467
98SIK10.54799653
99MAP3K70.53802518
100AURKA0.53248487
101DDR20.52946516
102RPS6KA30.52645681
103CAMK1D0.52191223
104MAP3K100.51442595
105DYRK20.50690871
106PRKCE0.50321587
107MAPK120.49214238
108PDPK10.47985775
109PKN10.47889808
110TNK20.47160681
111MAPK40.47159024
112MAP2K20.46870348
113MAP2K10.46737607
114AKT20.46531046
115RPS6KA20.46377969
116RPS6KA60.46258303
117CAMK40.44688205
118MAP3K10.44322874
119PAK20.44005089
120CDK190.43855995
121DYRK1B0.43447539
122LIMK10.43245869
123CDK120.43099232
124ROCK10.42336727
125CAMK2G0.42210262
126PIM20.41194776
127MAPK100.40971037
128FYN0.40568602
129WNK10.40541425
130PTK2B0.39846555
131MAP3K60.39582785
132DMPK0.38700154
133PRKAA10.37845971
134MAP3K130.37717053
135PDK10.37567158
136CAMK2D0.36437309

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.15235608
2Vitamin B6 metabolism_Homo sapiens_hsa007502.69852842
3Synaptic vesicle cycle_Homo sapiens_hsa047212.66474212
4GABAergic synapse_Homo sapiens_hsa047272.47643939
5Nitrogen metabolism_Homo sapiens_hsa009102.47211151
6Circadian entrainment_Homo sapiens_hsa047132.25438060
7Glutamatergic synapse_Homo sapiens_hsa047242.21710948
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19507178
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08796823
10Long-term potentiation_Homo sapiens_hsa047202.05343277
11Olfactory transduction_Homo sapiens_hsa047402.04317363
12Morphine addiction_Homo sapiens_hsa050322.03514252
13Amphetamine addiction_Homo sapiens_hsa050311.94512412
14Insulin secretion_Homo sapiens_hsa049111.93046007
15Sulfur relay system_Homo sapiens_hsa041221.87273225
16Dopaminergic synapse_Homo sapiens_hsa047281.82162253
17Salivary secretion_Homo sapiens_hsa049701.76363309
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75087406
19Cholinergic synapse_Homo sapiens_hsa047251.61762982
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60527173
21Cocaine addiction_Homo sapiens_hsa050301.55396912
22Gastric acid secretion_Homo sapiens_hsa049711.51650625
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47818403
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47619058
25Taste transduction_Homo sapiens_hsa047421.46589349
26Renin secretion_Homo sapiens_hsa049241.45661274
27Butanoate metabolism_Homo sapiens_hsa006501.39869951
28Long-term depression_Homo sapiens_hsa047301.34569465
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31813876
30Type II diabetes mellitus_Homo sapiens_hsa049301.29699062
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27118077
32Oxytocin signaling pathway_Homo sapiens_hsa049211.25484942
33Notch signaling pathway_Homo sapiens_hsa043301.23895352
34Bile secretion_Homo sapiens_hsa049761.22392154
35Serotonergic synapse_Homo sapiens_hsa047261.21957768
36Gap junction_Homo sapiens_hsa045401.20006869
37Axon guidance_Homo sapiens_hsa043601.19944472
38Calcium signaling pathway_Homo sapiens_hsa040201.19432619
39Arginine biosynthesis_Homo sapiens_hsa002201.19281880
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19144029
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15994834
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.15170238
43GnRH signaling pathway_Homo sapiens_hsa049121.11050791
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10745858
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08059174
46cAMP signaling pathway_Homo sapiens_hsa040241.04953405
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.03601025
48Melanogenesis_Homo sapiens_hsa049161.03310278
49Fatty acid biosynthesis_Homo sapiens_hsa000611.01785834
50Estrogen signaling pathway_Homo sapiens_hsa049151.01111445
51Arginine and proline metabolism_Homo sapiens_hsa003301.00119316
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99611779
53Phenylalanine metabolism_Homo sapiens_hsa003600.97145419
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96339274
55Glioma_Homo sapiens_hsa052140.94847920
56Non-small cell lung cancer_Homo sapiens_hsa052230.94076259
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92140138
58Biosynthesis of amino acids_Homo sapiens_hsa012300.89866818
59Other glycan degradation_Homo sapiens_hsa005110.88813543
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88179997
61Bladder cancer_Homo sapiens_hsa052190.85506156
62Alcoholism_Homo sapiens_hsa050340.85203530
63Chronic myeloid leukemia_Homo sapiens_hsa052200.83336373
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83243875
65Glucagon signaling pathway_Homo sapiens_hsa049220.80124689
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.79825631
67ErbB signaling pathway_Homo sapiens_hsa040120.78420358
68Cardiac muscle contraction_Homo sapiens_hsa042600.77571032
69Thyroid hormone synthesis_Homo sapiens_hsa049180.76580681
70Fatty acid metabolism_Homo sapiens_hsa012120.76126727
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75541252
72Basal cell carcinoma_Homo sapiens_hsa052170.75463899
73Dorso-ventral axis formation_Homo sapiens_hsa043200.73290238
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.72182156
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71373905
76Collecting duct acid secretion_Homo sapiens_hsa049660.69541921
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.68676220
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.68488161
79PPAR signaling pathway_Homo sapiens_hsa033200.67229312
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66327046
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.66071655
82Dilated cardiomyopathy_Homo sapiens_hsa054140.64856511
83Focal adhesion_Homo sapiens_hsa045100.64321412
84Renal cell carcinoma_Homo sapiens_hsa052110.64279870
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63783589
86Hippo signaling pathway_Homo sapiens_hsa043900.63371790
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62610057
88Insulin signaling pathway_Homo sapiens_hsa049100.60657795
89Pancreatic secretion_Homo sapiens_hsa049720.58987803
90Prion diseases_Homo sapiens_hsa050200.58833667
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58317230
92Lysine degradation_Homo sapiens_hsa003100.57204983
93Inositol phosphate metabolism_Homo sapiens_hsa005620.56924616
94Choline metabolism in cancer_Homo sapiens_hsa052310.56832193
95Fatty acid degradation_Homo sapiens_hsa000710.56169402
96Pentose phosphate pathway_Homo sapiens_hsa000300.55761228
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53458563
98Endometrial cancer_Homo sapiens_hsa052130.53004879
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52062787
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51779572
101Galactose metabolism_Homo sapiens_hsa000520.51333854
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51086197
103Propanoate metabolism_Homo sapiens_hsa006400.50623330
104Acute myeloid leukemia_Homo sapiens_hsa052210.49371037
105Proteoglycans in cancer_Homo sapiens_hsa052050.49097786
106Endocytosis_Homo sapiens_hsa041440.48823895
107Melanoma_Homo sapiens_hsa052180.48225361
108Fructose and mannose metabolism_Homo sapiens_hsa000510.48082639
109Oocyte meiosis_Homo sapiens_hsa041140.47734033
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47195455
111Vibrio cholerae infection_Homo sapiens_hsa051100.46820006
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45118858
113Tryptophan metabolism_Homo sapiens_hsa003800.44597082
114Wnt signaling pathway_Homo sapiens_hsa043100.44369403
115mTOR signaling pathway_Homo sapiens_hsa041500.43899479
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43739062
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43633202
118Hedgehog signaling pathway_Homo sapiens_hsa043400.42990988
119MAPK signaling pathway_Homo sapiens_hsa040100.42986713
120Circadian rhythm_Homo sapiens_hsa047100.41438147
121Glycerolipid metabolism_Homo sapiens_hsa005610.40439026
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.40381951
123AMPK signaling pathway_Homo sapiens_hsa041520.39746165
124Rap1 signaling pathway_Homo sapiens_hsa040150.37567411
125Ras signaling pathway_Homo sapiens_hsa040140.36683191
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35176980
127Phototransduction_Homo sapiens_hsa047440.34533356
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.34141649
129VEGF signaling pathway_Homo sapiens_hsa043700.33716869

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