LRP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)6.59844850
2regulation of type B pancreatic cell apoptotic process (GO:2000674)5.53020635
3endocrine pancreas development (GO:0031018)5.31500885
4cellular potassium ion homeostasis (GO:0030007)5.06973449
5axon ensheathment in central nervous system (GO:0032291)5.06907934
6central nervous system myelination (GO:0022010)5.06907934
7sodium ion export (GO:0071436)4.98939771
8L-amino acid import (GO:0043092)4.98398075
9amino acid import (GO:0043090)4.75755982
10* postsynaptic membrane organization (GO:0001941)4.53576182
11positive regulation of hormone metabolic process (GO:0032352)4.51068683
12glandular epithelial cell differentiation (GO:0002067)4.48235617
13negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.45340443
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.44447448
15positive regulation of cellular amine metabolic process (GO:0033240)4.37649756
16locomotory exploration behavior (GO:0035641)4.16808661
17* presynaptic membrane assembly (GO:0097105)4.11065045
18potassium ion import (GO:0010107)4.10893364
19neuron cell-cell adhesion (GO:0007158)4.06395127
20vocalization behavior (GO:0071625)4.06293899
21negative regulation of osteoblast proliferation (GO:0033689)3.95145576
22potassium ion homeostasis (GO:0055075)3.91279589
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.86529275
24cell communication by electrical coupling (GO:0010644)3.85657775
25* presynaptic membrane organization (GO:0097090)3.77403103
26negative regulation of transcription by competitive promoter binding (GO:0010944)3.77044443
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70647491
28respiratory chain complex IV assembly (GO:0008535)3.68272683
29synaptic vesicle maturation (GO:0016188)3.67718013
30nucleotide transmembrane transport (GO:1901679)3.66827137
313-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.66488254
32purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.66488254
33regulation of synaptic vesicle exocytosis (GO:2000300)3.63471350
34protein maturation by protein folding (GO:0022417)3.61844868
35peptide hormone processing (GO:0016486)3.61822804
36GDP-mannose metabolic process (GO:0019673)3.58861270
37neurotransmitter uptake (GO:0001504)3.57022148
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.56829320
39positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.56285989
40mannosylation (GO:0097502)3.53225365
41regulation of short-term neuronal synaptic plasticity (GO:0048172)3.50263371
42cellular sodium ion homeostasis (GO:0006883)3.48646846
43positive regulation of hormone biosynthetic process (GO:0046886)3.48249872
44exploration behavior (GO:0035640)3.43673440
45cerebellar granule cell differentiation (GO:0021707)3.42356334
46neuronal action potential propagation (GO:0019227)3.39678881
47regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.39482001
48glutamate secretion (GO:0014047)3.36649548
49regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.34968680
50sequestering of metal ion (GO:0051238)3.34595853
51nucleoside diphosphate catabolic process (GO:0009134)3.32781478
52cornea development in camera-type eye (GO:0061303)3.26455793
53negative regulation of keratinocyte proliferation (GO:0010839)3.26268980
54ionotropic glutamate receptor signaling pathway (GO:0035235)3.25777812
55dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.23497761
56regulation of neuronal synaptic plasticity (GO:0048168)3.23365629
57photoreceptor cell maintenance (GO:0045494)3.23296220
58astrocyte differentiation (GO:0048708)3.22614460
59astrocyte development (GO:0014002)3.20827526
60androgen biosynthetic process (GO:0006702)3.20465660
61layer formation in cerebral cortex (GO:0021819)3.20293161
62neuronal ion channel clustering (GO:0045161)3.19590601
63photoreceptor cell differentiation (GO:0046530)3.17300825
64eye photoreceptor cell differentiation (GO:0001754)3.17300825
65positive regulation of protein kinase C signaling (GO:0090037)3.14577997
66neurotransmitter-gated ion channel clustering (GO:0072578)3.13144354
67facial nerve structural organization (GO:0021612)3.12949684
68negative regulation of myotube differentiation (GO:0010832)3.11859445
69dermatan sulfate biosynthetic process (GO:0030208)3.10744210
70nephron tubule formation (GO:0072079)3.08003502
71magnesium ion transport (GO:0015693)3.07324473
72cytochrome complex assembly (GO:0017004)3.06572812
73neuromuscular process controlling balance (GO:0050885)3.05115163
74myelination in peripheral nervous system (GO:0022011)3.04346666
75peripheral nervous system axon ensheathment (GO:0032292)3.04346666
76photoreceptor cell development (GO:0042461)3.03870560
77regulation of pigment cell differentiation (GO:0050932)3.03424712
78synaptic vesicle exocytosis (GO:0016079)3.02484536
79acidic amino acid transport (GO:0015800)3.01614000
80GMP metabolic process (GO:0046037)3.01206135
81regulation of synaptic vesicle transport (GO:1902803)3.00594793
82metanephric nephron tubule development (GO:0072234)3.00034760
83metanephric tubule development (GO:0072170)3.00034760
84eye photoreceptor cell development (GO:0042462)2.99606505
85negative regulation of norepinephrine secretion (GO:0010700)2.98851103
86positive regulation of insulin secretion (GO:0032024)2.97440276
87regulation of glucokinase activity (GO:0033131)2.96728637
88regulation of hexokinase activity (GO:1903299)2.96728637
89protein localization to synapse (GO:0035418)2.95897936
90cell differentiation involved in metanephros development (GO:0072202)2.95798460
91regulation of glutamate receptor signaling pathway (GO:1900449)2.95691492
92cell communication involved in cardiac conduction (GO:0086065)2.94973626
93omega-hydroxylase P450 pathway (GO:0097267)2.94744098
94response to auditory stimulus (GO:0010996)2.93845076
95retinal rod cell development (GO:0046548)2.93415836
96pattern specification involved in kidney development (GO:0061004)2.93060453
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.92852799
98glandular epithelial cell development (GO:0002068)2.92045897
99glycoside metabolic process (GO:0016137)2.91793103
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90356181
101auditory behavior (GO:0031223)2.90118949
102prenylation (GO:0097354)2.90096346
103protein prenylation (GO:0018342)2.90096346
104negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.89982771
105cranial nerve morphogenesis (GO:0021602)2.87627598
106nephron epithelium development (GO:0072009)2.86703853
107C-terminal protein lipidation (GO:0006501)2.85953887
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.84853825
109epithelial cell fate commitment (GO:0072148)2.84206204
110dermatan sulfate metabolic process (GO:0030205)2.83105337
111myelination (GO:0042552)2.82571923
112regulation of timing of cell differentiation (GO:0048505)2.82410951
113GPI anchor biosynthetic process (GO:0006506)2.82253259
114intraciliary transport (GO:0042073)2.81222614
115neuron recognition (GO:0008038)2.81216719
116regulation of synapse structural plasticity (GO:0051823)2.80056887
117protein localization to Golgi apparatus (GO:0034067)2.79288180
118maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.75915063
119exocrine pancreas development (GO:0031017)2.75676004
120toxin metabolic process (GO:0009404)2.75675140
121regulation of long-term neuronal synaptic plasticity (GO:0048169)2.74637501
122axonal fasciculation (GO:0007413)2.74027052
123L-glutamate transport (GO:0015813)2.73104211
124mesenchymal cell differentiation involved in kidney development (GO:0072161)2.72694135
125mesenchymal cell differentiation involved in renal system development (GO:2001012)2.72694135
126axon ensheathment (GO:0008366)2.72675596
127ensheathment of neurons (GO:0007272)2.72675596
128auditory receptor cell differentiation (GO:0042491)2.70834414
129negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.70128866
130regulation of oxidative phosphorylation (GO:0002082)2.69824587
131synaptic transmission, glutamatergic (GO:0035249)2.69236959
132cranial nerve development (GO:0021545)2.68795929
133notochord development (GO:0030903)2.68536190
134type B pancreatic cell development (GO:0003323)2.68328247
135regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.68098972
136mechanosensory behavior (GO:0007638)2.65897313
137metanephric nephron epithelium development (GO:0072243)2.64981089
138chondroitin sulfate catabolic process (GO:0030207)2.63637782
139regulation of cardiac muscle cell contraction (GO:0086004)2.63008021
140ER overload response (GO:0006983)2.62917695
141renal tubule development (GO:0061326)2.62560068
142neurotransmitter secretion (GO:0007269)2.61572238
143regulation of respiratory system process (GO:0044065)2.61483621
144positive regulation of protein sumoylation (GO:0033235)2.60424007
145C4-dicarboxylate transport (GO:0015740)2.59880717
146cerebellar Purkinje cell layer development (GO:0021680)2.59621410
147apical protein localization (GO:0045176)2.59599956
148endothelium development (GO:0003158)2.59062060
149oligodendrocyte differentiation (GO:0048709)2.58911995
150metanephric epithelium development (GO:0072207)2.58694643
151positive regulation of glycolytic process (GO:0045821)2.58284879
152regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.58146616
153sphingoid metabolic process (GO:0046519)2.58012078
154glycosphingolipid catabolic process (GO:0046479)2.56412365
155GPI anchor metabolic process (GO:0006505)2.56275986
156negative regulation of astrocyte differentiation (GO:0048712)2.53917271
157nephron tubule development (GO:0072080)2.53472233
158regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.52509090
159embryonic retina morphogenesis in camera-type eye (GO:0060059)2.51850262
160positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.51457002
161regulation of development, heterochronic (GO:0040034)2.51319762
162positive regulation of dendritic spine development (GO:0060999)2.51256752
163cGMP-mediated signaling (GO:0019934)2.51151093
164Golgi transport vesicle coating (GO:0048200)2.50424686
165COPI coating of Golgi vesicle (GO:0048205)2.50424686
166cranial nerve structural organization (GO:0021604)2.50386408
167pharyngeal system development (GO:0060037)2.50344037
168negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50155373
169long-chain fatty acid biosynthetic process (GO:0042759)2.48432308
170protein retention in ER lumen (GO:0006621)2.48246078
171positive regulation of steroid hormone secretion (GO:2000833)2.48130762
172developmental pigmentation (GO:0048066)2.47916497
173interleukin-1-mediated signaling pathway (GO:0070498)2.46672883
174blood coagulation, intrinsic pathway (GO:0007597)2.46448348
175regulation of hormone metabolic process (GO:0032350)2.45655905
176regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.45555952
177insulin secretion (GO:0030073)2.44619152
178inner ear receptor cell differentiation (GO:0060113)2.44572896
179cellular response to cholesterol (GO:0071397)2.43967338
180positive regulation of synapse maturation (GO:0090129)2.42365020
181regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.41749422
182neurotransmitter transport (GO:0006836)2.41432999
183paraxial mesoderm development (GO:0048339)2.41091182
184positive regulation of dendrite development (GO:1900006)2.38307711
185synaptic vesicle endocytosis (GO:0048488)2.38028830
186neuron projection regeneration (GO:0031102)2.36682334
187regulation of synaptic plasticity (GO:0048167)2.35576414
188* membrane assembly (GO:0071709)2.35078680
189glutamate receptor signaling pathway (GO:0007215)2.34970806
190transmission of nerve impulse (GO:0019226)2.33674310
191dendritic spine morphogenesis (GO:0060997)2.32392783
192regulation of respiratory gaseous exchange (GO:0043576)2.32209642
193regulation of axon extension involved in axon guidance (GO:0048841)2.32169510
194regulation of dendritic spine morphogenesis (GO:0061001)2.31697840
195* dendrite morphogenesis (GO:0048813)2.31641945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.84665744
2GBX2_23144817_ChIP-Seq_PC3_Human3.13383556
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.61286046
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50033418
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29212936
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.17003793
7DROSHA_22980978_ChIP-Seq_HELA_Human2.16387460
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14588474
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06556367
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05876710
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05306821
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03353102
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01324622
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.00849176
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.00533154
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.99638471
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98527851
18GATA1_22025678_ChIP-Seq_K562_Human1.97962427
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97255126
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92085914
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.90162448
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88893162
23REST_21632747_ChIP-Seq_MESCs_Mouse1.88178292
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85055823
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.84759936
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83629301
27AR_21572438_ChIP-Seq_LNCaP_Human1.80887258
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79239771
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.78021211
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75447587
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73380217
32* EZH2_27294783_Chip-Seq_ESCs_Mouse1.71274992
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.68881833
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.67177897
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.65894839
36P53_22387025_ChIP-Seq_ESCs_Mouse1.63829443
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.62824875
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62612018
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61587663
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.61317037
41* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.60576564
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58895930
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.58877497
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58585567
45* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57766046
46* RING1B_27294783_Chip-Seq_ESCs_Mouse1.57391967
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57173611
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55669949
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.55330701
50STAT3_18555785_Chip-Seq_ESCs_Mouse1.55288602
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54957718
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54218880
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54117006
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54117006
55CTNNB1_20460455_ChIP-Seq_HCT116_Human1.52960808
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51413442
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.51308545
58* NMYC_18555785_Chip-Seq_ESCs_Mouse1.50421047
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49781561
60SUZ12_18555785_Chip-Seq_ESCs_Mouse1.48755030
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47943101
62YAP1_20516196_ChIP-Seq_MESCs_Mouse1.47723154
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47167817
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45893298
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45124861
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.45086437
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.45045934
68* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.43393746
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42665042
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.42111188
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42049209
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39642058
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38750901
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.37579623
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36548565
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35411300
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34938949
78* SOX2_18555785_Chip-Seq_ESCs_Mouse1.34803526
79* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.34506240
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.34099224
81VDR_22108803_ChIP-Seq_LS180_Human1.33842760
82* P300_18555785_Chip-Seq_ESCs_Mouse1.32909282
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31753897
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.31362009
85IGF1R_20145208_ChIP-Seq_DFB_Human1.30565283
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28902673
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24943915
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24278336
89KLF4_18555785_Chip-Seq_ESCs_Mouse1.24189159
90* ZFX_18555785_Chip-Seq_ESCs_Mouse1.23642323
91P300_19829295_ChIP-Seq_ESCs_Human1.23079171
92ESRRB_18555785_Chip-Seq_ESCs_Mouse1.23020850
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22017165
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.21873626
95* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20544933
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20215827
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19841623
98OCT4_18555785_Chip-Seq_ESCs_Mouse1.19238087
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.19129325
100* KDM2B_26808549_Chip-Seq_K562_Human1.18995947
101* PU1_27457419_Chip-Seq_LIVER_Mouse1.18853465
102* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.18789171
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.18335969
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18023259
105BCAT_22108803_ChIP-Seq_LS180_Human1.17869725
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.17685610
107AR_19668381_ChIP-Seq_PC3_Human1.16820390
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16584547
109TP53_18474530_ChIP-ChIP_U2OS_Human1.15747286
110CTCF_18555785_Chip-Seq_ESCs_Mouse1.14698249
111CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13009419
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12279654
113GATA1_26923725_Chip-Seq_HPCs_Mouse1.12099485
114RUNX2_22187159_ChIP-Seq_PCA_Human1.12012404
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.11985312
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11575256
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11570396
118SMAD3_21741376_ChIP-Seq_HESCs_Human1.11249269
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10902979
120RNF2_27304074_Chip-Seq_NSC_Mouse1.09981790
121SOX9_26525672_Chip-Seq_HEART_Mouse1.08388971
122OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07571925
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07482101
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07247018
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07065598
126KDM2B_26808549_Chip-Seq_REH_Human1.06987948
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06504803
128SMAD4_21799915_ChIP-Seq_A2780_Human1.06377449
129SMAD3_21741376_ChIP-Seq_EPCs_Human1.05781332
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05253843
131NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05161188
132SMAD4_21741376_ChIP-Seq_HESCs_Human1.04595012
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04309679
134POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02631058
135TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01859131
136IRF1_19129219_ChIP-ChIP_H3396_Human1.01689936
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01304936
138NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01284223
139POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01198591
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01167677
141TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01002234
142SMAD3_21741376_ChIP-Seq_ESCs_Human1.00414869
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00189149
144LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00140984
145SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99733353
146NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98666135
147POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97913073
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97714442
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97473326
150P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94513338
151OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94432991
152NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.94332301
153PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.93971694
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93633898
155TP53_20018659_ChIP-ChIP_R1E_Mouse0.92859453
156TP63_17297297_ChIP-ChIP_HaCaT_Human0.92607547
157PHF8_20622853_ChIP-Seq_HELA_Human0.92316768
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91669651
159TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91666311
160ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90610675
161CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89873579
162* RING1B_27294783_Chip-Seq_NPCs_Mouse0.89368873
163ERG_20517297_ChIP-Seq_VCAP_Human0.88240461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.38700050
2MP0003136_yellow_coat_color4.35260936
3MP0009379_abnormal_foot_pigmentation3.80269176
4MP0004270_analgesia3.73567727
5MP0005409_darkened_coat_color3.73203390
6MP0001188_hyperpigmentation3.60714059
7MP0006292_abnormal_olfactory_placode3.46642462
8MP0004043_abnormal_pH_regulation3.43800793
9MP0003880_abnormal_central_pattern3.15190974
10MP0005423_abnormal_somatic_nervous2.98899075
11MP0006072_abnormal_retinal_apoptosis2.96632501
12MP0002877_abnormal_melanocyte_morpholog2.96130290
13MP0001986_abnormal_taste_sensitivity2.78406257
14MP0002638_abnormal_pupillary_reflex2.76149949
15MP0004381_abnormal_hair_follicle2.75237998
16MP0003635_abnormal_synaptic_transmissio2.58708459
17MP0010386_abnormal_urinary_bladder2.52583494
18MP0002876_abnormal_thyroid_physiology2.51662671
19MP0002693_abnormal_pancreas_physiology2.48789583
20MP0005379_endocrine/exocrine_gland_phen2.46753324
21MP0001944_abnormal_pancreas_morphology2.39867252
22MP0001486_abnormal_startle_reflex2.33145902
23MP0003183_abnormal_peptide_metabolism2.27656845
24MP0002064_seizures2.24865965
25MP0009780_abnormal_chondrocyte_physiolo2.24538474
26MP0002734_abnormal_mechanical_nocicepti2.20237063
27MP0003868_abnormal_feces_composition2.17060585
28MP0000566_synostosis2.16533507
29MP0005174_abnormal_tail_pigmentation2.16129146
30MP0000778_abnormal_nervous_system2.14584570
31MP0000678_abnormal_parathyroid_gland2.14361146
32MP0003690_abnormal_glial_cell2.06747574
33MP0002063_abnormal_learning/memory/cond2.06600265
34MP0005257_abnormal_intraocular_pressure2.01769490
35MP0001984_abnormal_olfaction2.00654414
36MP0000015_abnormal_ear_pigmentation2.00056099
37MP0001502_abnormal_circadian_rhythm1.99810110
38MP0001346_abnormal_lacrimal_gland1.90534194
39MP0002272_abnormal_nervous_system1.83728492
40MP0008569_lethality_at_weaning1.82301150
41MP0005220_abnormal_exocrine_pancreas1.80091020
42MP0005646_abnormal_pituitary_gland1.79137609
43MP0005253_abnormal_eye_physiology1.79100396
44MP0003329_amyloid_beta_deposits1.78455104
45MP0005551_abnormal_eye_electrophysiolog1.76085707
46MP0009745_abnormal_behavioral_response1.75322316
47MP0002572_abnormal_emotion/affect_behav1.70922651
48MP0002177_abnormal_outer_ear1.66870094
49MP0002736_abnormal_nociception_after1.65868905
50MP0002139_abnormal_hepatobiliary_system1.65438077
51MP0000613_abnormal_salivary_gland1.61479785
52MP0003724_increased_susceptibility_to1.60466065
53MP0000920_abnormal_myelination1.59198860
54MP0003634_abnormal_glial_cell1.56842983
55MP0000955_abnormal_spinal_cord1.55698778
56MP0002822_catalepsy1.55614502
57MP0003283_abnormal_digestive_organ1.55124141
58MP0000049_abnormal_middle_ear1.48658717
59MP0001968_abnormal_touch/_nociception1.48191295
60MP0002735_abnormal_chemical_nociception1.45865276
61MP0000681_abnormal_thyroid_gland1.44261340
62MP0002277_abnormal_respiratory_mucosa1.43731371
63MP0000631_abnormal_neuroendocrine_gland1.43102970
64MP0003011_delayed_dark_adaptation1.41684862
65MP0002837_dystrophic_cardiac_calcinosis1.41142670
66MP0003705_abnormal_hypodermis_morpholog1.41124058
67MP0001501_abnormal_sleep_pattern1.41106876
68MP0005171_absent_coat_pigmentation1.37975384
69MP0004858_abnormal_nervous_system1.35025446
70MP0003632_abnormal_nervous_system1.34492448
71MP0002938_white_spotting1.33487444
72MP0002095_abnormal_skin_pigmentation1.31465143
73MP0009046_muscle_twitch1.29303758
74* MP0001177_atelectasis1.28310421
75MP0008789_abnormal_olfactory_epithelium1.27336133
76MP0001970_abnormal_pain_threshold1.25653281
77* MP0000579_abnormal_nail_morphology1.25083992
78MP0002152_abnormal_brain_morphology1.24983840
79* MP0002882_abnormal_neuron_morphology1.24320050
80MP0002067_abnormal_sensory_capabilities1.20258298
81MP0000372_irregular_coat_pigmentation1.19458819
82MP0000013_abnormal_adipose_tissue1.19139040
83MP0002733_abnormal_thermal_nociception1.18031261
84MP0004811_abnormal_neuron_physiology1.18025514
85MP0003633_abnormal_nervous_system1.15780017
86* MP0002557_abnormal_social/conspecific_i1.14632091
87MP0001270_distended_abdomen1.13360479
88MP0000751_myopathy1.13318467
89MP0010368_abnormal_lymphatic_system1.12551706
90MP0000537_abnormal_urethra_morphology1.12130027
91MP0003941_abnormal_skin_development1.10565882
92MP0003195_calcinosis1.09977506
93MP0003861_abnormal_nervous_system1.09342937
94MP0001919_abnormal_reproductive_system1.08858376
95MP0003631_nervous_system_phenotype1.08488480
96MP0010030_abnormal_orbit_morphology1.08473652
97MP0003879_abnormal_hair_cell1.08355156
98MP0000428_abnormal_craniofacial_morphol1.08315245
99MP0002254_reproductive_system_inflammat1.08295517
100MP0002009_preneoplasia1.05210191
101MP0000762_abnormal_tongue_morphology1.04630612
102* MP0002066_abnormal_motor_capabilities/c1.03619036
103MP0002078_abnormal_glucose_homeostasis1.03138888
104MP0002184_abnormal_innervation1.02303186
105MP0003119_abnormal_digestive_system0.99451312
106MP0002751_abnormal_autonomic_nervous0.96518471
107MP0000534_abnormal_ureter_morphology0.96244898
108MP0005248_abnormal_Harderian_gland0.96037888
109MP0002089_abnormal_postnatal_growth/wei0.95452809
110MP0003122_maternal_imprinting0.95434538
111MP0003123_paternal_imprinting0.95259286
112MP0002653_abnormal_ependyma_morphology0.94101919
113MP0002697_abnormal_eye_size0.92091245
114MP0000026_abnormal_inner_ear0.91614721
115MP0003385_abnormal_body_wall0.91389798
116MP0000462_abnormal_digestive_system0.91240440
117MP0008875_abnormal_xenobiotic_pharmacok0.91139454
118MP0003938_abnormal_ear_development0.90978592
119MP0005408_hypopigmentation0.89820451
120MP0002163_abnormal_gland_morphology0.89155763
121MP0002233_abnormal_nose_morphology0.87718448
122MP0002249_abnormal_larynx_morphology0.86232431
123MP0005499_abnormal_olfactory_system0.85687269
124MP0005394_taste/olfaction_phenotype0.85687269
125MP0000749_muscle_degeneration0.85112448
126MP0001186_pigmentation_phenotype0.84251017
127MP0005623_abnormal_meninges_morphology0.83821853
128MP0004272_abnormal_basement_membrane0.83682969
129MP0003252_abnormal_bile_duct0.83497471
130MP0000747_muscle_weakness0.82206681
131MP0001661_extended_life_span0.81777226
132MP0005595_abnormal_vascular_smooth0.81406062
133MP0002928_abnormal_bile_duct0.79756368
134MP0005391_vision/eye_phenotype0.79200591
135MP0001440_abnormal_grooming_behavior0.78534198
136MP0009053_abnormal_anal_canal0.78381922
137MP0004924_abnormal_behavior0.77624666
138MP0005386_behavior/neurological_phenoty0.77624666
139MP0002138_abnormal_hepatobiliary_system0.76970549
140MP0003115_abnormal_respiratory_system0.76052424
141MP0005058_abnormal_lysosome_morphology0.74792633
142MP0000383_abnormal_hair_follicle0.74710877
143MP0001324_abnormal_eye_pigmentation0.73976640
144MP0001963_abnormal_hearing_physiology0.73868311
145MP0003942_abnormal_urinary_system0.73651403
146MP0004782_abnormal_surfactant_physiolog0.73492198
147* MP0002752_abnormal_somatic_nervous0.73483783
148MP0001849_ear_inflammation0.73235308
149MP0002116_abnormal_craniofacial_bone0.72300516
150MP0001485_abnormal_pinna_reflex0.70850197
151MP0005195_abnormal_posterior_eye0.70577762
152MP0004885_abnormal_endolymph0.70562347
153MP0001299_abnormal_eye_distance/0.70312856
154MP0000538_abnormal_urinary_bladder0.70138866
155MP0005645_abnormal_hypothalamus_physiol0.69975981
156* MP0003937_abnormal_limbs/digits/tail_de0.69392491
157MP0005167_abnormal_blood-brain_barrier0.69128774
158MP0005084_abnormal_gallbladder_morpholo0.68057865
159MP0002896_abnormal_bone_mineralization0.66714340
160MP0000467_abnormal_esophagus_morphology0.65829127
161MP0009250_abnormal_appendicular_skeleto0.63988217
162MP0003953_abnormal_hormone_level0.63921263
163MP0001664_abnormal_digestion0.63042992
164MP0002229_neurodegeneration0.62216456
165MP0001765_abnormal_ion_homeostasis0.59839691
166MP0002909_abnormal_adrenal_gland0.57634854
167MP0005389_reproductive_system_phenotype0.56897500
168MP0009384_cardiac_valve_regurgitation0.56095790
169MP0002075_abnormal_coat/hair_pigmentati0.55796984
170* MP0002098_abnormal_vibrissa_morphology0.54958355
171MP0005085_abnormal_gallbladder_physiolo0.54955536
172MP0002998_abnormal_bone_remodeling0.54729939
173MP0009643_abnormal_urine_homeostasis0.52171359
174MP0008995_early_reproductive_senescence0.50250875
175MP0005636_abnormal_mineral_homeostasis0.49613752

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)5.79486956
2Prolonged partial thromboplastin time (HP:0003645)5.56244714
3Reduced antithrombin III activity (HP:0001976)5.40339982
4Hypothermia (HP:0002045)5.13434435
5Absent rod-and cone-mediated responses on ERG (HP:0007688)5.08054545
6Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.64081906
7Abnormal protein N-linked glycosylation (HP:0012347)4.64081906
8Abnormal protein glycosylation (HP:0012346)4.64081906
9Abnormal glycosylation (HP:0012345)4.64081906
10Abnormal rod and cone electroretinograms (HP:0008323)4.20926875
11Myokymia (HP:0002411)3.80755128
12Symptomatic seizures (HP:0011145)3.71664530
13Hypoglycemic seizures (HP:0002173)3.65775355
14Focal motor seizures (HP:0011153)3.62103495
15Hyperinsulinemic hypoglycemia (HP:0000825)3.56458249
16Attenuation of retinal blood vessels (HP:0007843)3.43065696
17Action tremor (HP:0002345)3.41188157
18Aplasia involving bones of the extremities (HP:0009825)3.37587690
19Aplasia involving bones of the upper limbs (HP:0009823)3.37587690
20Aplasia of the phalanges of the hand (HP:0009802)3.37587690
21Megalencephaly (HP:0001355)3.32856181
22Neurofibrillary tangles (HP:0002185)3.31746641
23Late onset (HP:0003584)3.30150796
24Decreased circulating renin level (HP:0003351)3.24366915
25Congenital sensorineural hearing impairment (HP:0008527)3.21154637
26Abnormality of calcium-phosphate metabolism (HP:0100530)3.16940891
27Focal seizures (HP:0007359)3.12654119
28Cortical visual impairment (HP:0100704)3.12475115
29True hermaphroditism (HP:0010459)3.11898528
30Thyroid-stimulating hormone excess (HP:0002925)3.10237449
31Abnormal sex determination (HP:0012244)3.06556022
32Sex reversal (HP:0012245)3.06556022
33Hypoglycemic coma (HP:0001325)3.04532122
34Abnormality of binocular vision (HP:0011514)3.03974806
35Diplopia (HP:0000651)3.03974806
36Osteomalacia (HP:0002749)3.01579645
37Aplasia/Hypoplasia of the fovea (HP:0008060)2.97509671
38Hypoplasia of the fovea (HP:0007750)2.97509671
39Decreased central vision (HP:0007663)2.96860824
40Aplasia/hypoplasia of the uterus (HP:0008684)2.90570830
41Tubulointerstitial nephritis (HP:0001970)2.78973654
42Neonatal short-limb short stature (HP:0008921)2.75907274
43Joint hemorrhage (HP:0005261)2.75455092
44Bronchomalacia (HP:0002780)2.74630151
45Abnormality of aromatic amino acid family metabolism (HP:0004338)2.72684742
46Abnormality of the fovea (HP:0000493)2.71883866
47Abnormality of secondary sexual hair (HP:0009888)2.69679258
48Abnormality of the axillary hair (HP:0100134)2.69679258
49Ankle clonus (HP:0011448)2.61480345
50Hemiplegia (HP:0002301)2.59227214
51Hemiparesis (HP:0001269)2.56199635
52Atonic seizures (HP:0010819)2.54222746
53Severe visual impairment (HP:0001141)2.53528892
54Hyperactive renin-angiotensin system (HP:0000841)2.53338557
55Turricephaly (HP:0000262)2.52698613
56Increased circulating renin level (HP:0000848)2.48650135
57Coronal craniosynostosis (HP:0004440)2.47744028
58Pancreatic cysts (HP:0001737)2.46457343
59Partial duplication of thumb phalanx (HP:0009944)2.45974637
60Pancreatic fibrosis (HP:0100732)2.45830962
61Shallow orbits (HP:0000586)2.45807049
62Alacrima (HP:0000522)2.43047672
63Peripheral hypomyelination (HP:0007182)2.42786610
64Optic nerve hypoplasia (HP:0000609)2.42560535
65Generalized aminoaciduria (HP:0002909)2.39577925
66Dysostosis multiplex (HP:0000943)2.34826289
67Hyperkalemia (HP:0002153)2.34213312
68Popliteal pterygium (HP:0009756)2.32038941
69Generalized tonic-clonic seizures (HP:0002069)2.30863838
70Cerebral inclusion bodies (HP:0100314)2.30339335
71Vacuolated lymphocytes (HP:0001922)2.28660438
72Dysdiadochokinesis (HP:0002075)2.26825028
73Abnormality of magnesium homeostasis (HP:0004921)2.24038004
74Renal cortical cysts (HP:0000803)2.23966739
75Insulin-resistant diabetes mellitus (HP:0000831)2.22812059
76Morphological abnormality of the inner ear (HP:0011390)2.22653239
77Choanal stenosis (HP:0000452)2.20904503
78Bradycardia (HP:0001662)2.19895848
79Abolished electroretinogram (ERG) (HP:0000550)2.17179342
80Overriding aorta (HP:0002623)2.14039593
81Insomnia (HP:0100785)2.13936511
82Lip pit (HP:0100267)2.11836192
83Increased corneal curvature (HP:0100692)2.10937846
84Keratoconus (HP:0000563)2.10937846
85Cystic liver disease (HP:0006706)2.10361583
86Abnormality of cochlea (HP:0000375)2.07693203
87Abnormality of the diencephalon (HP:0010662)2.06244967
88Vertebral arch anomaly (HP:0008438)2.05477786
89Partial duplication of the phalanx of hand (HP:0009999)2.04557060
90Supranuclear gaze palsy (HP:0000605)2.04219808
91Nonprogressive disorder (HP:0003680)2.04077388
92Abnormality of the ischium (HP:0003174)2.02995534
93Intestinal atresia (HP:0011100)2.02382633
94Obstructive sleep apnea (HP:0002870)2.02204765
95Cerebral palsy (HP:0100021)1.98190019
96Tracheomalacia (HP:0002779)1.97267316
97Febrile seizures (HP:0002373)1.96451655
98Truncal ataxia (HP:0002078)1.96273035
99Abnormal pancreas size (HP:0012094)1.95585195
100Progressive neurologic deterioration (HP:0002344)1.95224050
101Menorrhagia (HP:0000132)1.95200711
102Abnormality of renal resorption (HP:0011038)1.93833300
103Median cleft lip (HP:0000161)1.93391636
104Epileptic encephalopathy (HP:0200134)1.93347997
105Abnormality of renin-angiotensin system (HP:0000847)1.93344731
106Patchy hypopigmentation of hair (HP:0011365)1.91807412
107Hyperacusis (HP:0010780)1.91493467
108Abnormal eating behavior (HP:0100738)1.91490637
109Renal Fanconi syndrome (HP:0001994)1.90736686
110Male pseudohermaphroditism (HP:0000037)1.90726694
111Hepatic necrosis (HP:0002605)1.90680450
112Mucopolysacchariduria (HP:0008155)1.90249557
113Urinary glycosaminoglycan excretion (HP:0003541)1.90249557
114Abnormality of the intrinsic pathway (HP:0010989)1.89574292
115Abnormality of urine glucose concentration (HP:0011016)1.89099784
116Glycosuria (HP:0003076)1.89099784
117Abnormality of dental color (HP:0011073)1.89047571
118Scanning speech (HP:0002168)1.88157046
119Hypoplasia of the uterus (HP:0000013)1.87894921
120Intention tremor (HP:0002080)1.87246465
121Dysmetria (HP:0001310)1.86197244
122Spastic gait (HP:0002064)1.85962007
123* Cutaneous syndactyly (HP:0012725)1.84128301
124* Split foot (HP:0001839)1.83808649
125Thin ribs (HP:0000883)1.83024149
126Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82148730
127Hypokalemia (HP:0002900)1.82140282
128Decreased lacrimation (HP:0000633)1.80860729
129Thickened helices (HP:0000391)1.79985316
130Optic disc pallor (HP:0000543)1.79645105
131Renovascular hypertension (HP:0100817)1.79272251
132Abdominal distention (HP:0003270)1.79146442
133Morphological abnormality of the middle ear (HP:0008609)1.79096241
134* Cutaneous finger syndactyly (HP:0010554)1.78964250
135Bony spicule pigmentary retinopathy (HP:0007737)1.78958846
136Hammertoe (HP:0001765)1.78742723
137Renal tubular dysfunction (HP:0000124)1.77342339
138Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76958384
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.76199714
140Overgrowth (HP:0001548)1.75264454
141Akinesia (HP:0002304)1.74860186
142Ulnar bowing (HP:0003031)1.74761336
143Acne (HP:0001061)1.74751951
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74605384
145Abnormality of polysaccharide metabolism (HP:0011012)1.74605384
146Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74605384
147Hyporeflexia of lower limbs (HP:0002600)1.74179989
148Testicular atrophy (HP:0000029)1.74149572
149Papilledema (HP:0001085)1.74027050
150Hyperglycemia (HP:0003074)1.73583679
151Abnormality of potassium homeostasis (HP:0011042)1.73340441
152Flat capital femoral epiphysis (HP:0003370)1.72664837
153Bifid tongue (HP:0010297)1.72663348
154Flared iliac wings (HP:0002869)1.72646118
155Arnold-Chiari malformation (HP:0002308)1.71609191
156Anencephaly (HP:0002323)1.71163321
157Elfin facies (HP:0004428)1.70633941
158Urinary bladder sphincter dysfunction (HP:0002839)1.69578297
159Abnormality of the 4th metacarpal (HP:0010012)1.69530882
160Hyperphosphaturia (HP:0003109)1.69425308
161Congenital hepatic fibrosis (HP:0002612)1.69257209
162Broad metatarsal (HP:0001783)1.69128092
163Abnormality of liposaccharide metabolism (HP:0010968)1.68810214
164Abnormality of glycosphingolipid metabolism (HP:0004343)1.68810214
165Abnormality of glycolipid metabolism (HP:0010969)1.68810214
166Absent eyebrow (HP:0002223)1.68562751
167Sleep apnea (HP:0010535)1.67280732
168Omphalocele (HP:0001539)1.66339890
169Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65470300
170Hypoplasia of the iris (HP:0007676)1.64957472
171Preaxial foot polydactyly (HP:0001841)1.63719141
172Bowel incontinence (HP:0002607)1.63624408
173Wide anterior fontanel (HP:0000260)1.63257232
174Neoplasm of the heart (HP:0100544)1.62838226
175Limited hip movement (HP:0008800)1.62440096
176Tetraplegia (HP:0002445)1.61973121
177Ankyloglossia (HP:0010296)1.60208860
178Mixed hearing impairment (HP:0000410)1.59563455
179Urethral obstruction (HP:0000796)1.58131438
180Postural instability (HP:0002172)1.58120020
181Mild short stature (HP:0003502)1.57732007
182Bundle branch block (HP:0011710)1.56146246
183Increased nuchal translucency (HP:0010880)1.55988465
184Hepatoblastoma (HP:0002884)1.55928169
185Trigonocephaly (HP:0000243)1.54907331
186Bowel diverticulosis (HP:0005222)1.54330357
187Vitreoretinal degeneration (HP:0000655)1.53059634
188Dialeptic seizures (HP:0011146)1.51647881
189Urinary urgency (HP:0000012)1.51481923
190Absence seizures (HP:0002121)1.51432905
191Duplication of thumb phalanx (HP:0009942)1.50260136
192Difficulty running (HP:0009046)1.49806086
193Abnormality of the lower motor neuron (HP:0002366)1.48998719
194Pheochromocytoma (HP:0002666)1.47391003
195Myotonia (HP:0002486)1.45252912
196Renal duplication (HP:0000075)1.44901802
197Bladder diverticulum (HP:0000015)1.44672844
198Vertebral clefting (HP:0008428)1.43544955
199Lower limb muscle weakness (HP:0007340)1.43421229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.03147802
2CASK5.06377085
3MKNK24.37080869
4INSRR4.08153664
5MARK13.75977494
6EPHA43.75384607
7NTRK23.44928389
8EIF2AK33.44535549
9IRAK32.77632262
10NLK2.65629914
11IRAK22.46708073
12MAPK152.42234633
13PAK62.40849198
14TYRO32.40304278
15MUSK2.28688381
16RIPK12.22696921
17MKNK12.09901581
18FGFR21.97406454
19IRAK41.95120194
20HIPK21.90146759
21IRAK11.90092630
22PDGFRA1.87446769
23PASK1.87261766
24LATS21.87233404
25CAMKK21.81542764
26PRPF4B1.74309088
27STK161.54320363
28PNCK1.42954231
29TLK11.33503759
30FES1.31448572
31PRKD21.27869931
32EIF2AK21.26479274
33PKN11.25816827
34BMPR21.24315290
35SRPK11.24280699
36PBK1.23172046
37MAP3K91.22969770
38MINK11.20927162
39LATS11.20566726
40DAPK21.17980635
41PLK21.17719515
42LMTK21.16968548
43STK38L1.13054489
44KSR21.12429151
45CAMKK11.10945890
46ZAK1.10758435
47FLT31.09790866
48CDK51.06679534
49ROCK21.04499012
50ICK1.03785024
51TEC1.02918294
52YES11.02713598
53TAOK31.01577610
54NME21.00925873
55NTRK30.99592703
56MAP2K20.98176656
57MST1R0.96788184
58PRKD30.92521720
59PHKG10.91746863
60PHKG20.91746863
61CAMK1G0.91285611
62BMX0.91190501
63WNK40.90893955
64CDK30.90397156
65PINK10.89674321
66EPHB20.89341560
67DYRK1A0.88432161
68FER0.88326890
69NME10.88191478
70MAPK100.85275034
71MARK20.85227866
72SGK30.85190301
73EEF2K0.84659308
74FGFR10.82795128
75ERBB20.80238301
76PIK3CG0.79795799
77BMPR1B0.79418568
78ERBB40.78756629
79PDGFRB0.76690863
80SGK10.76628024
81BCKDK0.76339146
82CDK150.75600930
83PRKCG0.75004111
84RET0.74901811
85GRK10.71640220
86CDK180.71033248
87ROCK10.70236743
88CDK120.69865004
89EPHA30.69214791
90VRK10.68818597
91NEK60.68344322
92STK390.67920628
93CDK11A0.67635759
94ADRBK20.66792414
95DMPK0.66304669
96CAMK10.66085897
97FGFR40.65477697
98MAP3K40.65406423
99PRKCE0.64910051
100STK380.63053820
101BRAF0.63046131
102PTK20.62342257
103DDR20.61729983
104WNK10.60886304
105CDK140.60417130
106MAP3K100.60111307
107MAP2K70.60043990
108CAMK2B0.59585858
109PRKAA20.59491279
110CDC42BPA0.58383313
111PRKCH0.57307389
112ALK0.57023039
113CSNK1G20.53803772
114MTOR0.53535145
115MAPK130.52947218
116MAP3K140.52752425
117RPS6KA30.52401105
118ERN10.52295886
119MOS0.51503585
120KSR10.51408313
121CAMK2D0.50563735
122MAP3K10.50181515
123MAPK120.49886139
124MAP3K70.49725181
125ARAF0.49485083
126BRSK10.49245106
127MAP3K20.48557180
128ERBB30.47530574
129RPS6KB10.45635313
130PRKDC0.44035715
131CAMK1D0.43763615
132FRK0.43242817
133DYRK1B0.43117887
134PAK20.42883961
135BRD40.42871703
136CDK80.41968801
137PIK3CA0.41831536
138FGFR30.41726808
139TIE10.41168385
140TRIB30.41059398
141CLK10.40330859
142MET0.40196965
143NTRK10.40193689
144PRKG20.40158714
145STK110.40076644
146CSNK1D0.39796904
147UHMK10.39619370
148AKT30.39222913
149DYRK30.38057472
150CSK0.35466143
151PRKG10.35291233
152SIK10.33832241
153PRKACA0.33757947
154PIM20.33533368
155CAMK2G0.33137629
156NUAK10.32623852
157IKBKE0.32393959
158GRK70.31133709
159PRKCI0.29687367
160CAMK2A0.29262406
161GSK3A0.28936577
162SGK20.28229052
163SGK4940.27778118
164SGK2230.27778118
165CAMK40.27738731
166PRKD10.27224024
167OBSCN0.23980974
168BTK0.23818626
169CSNK1A1L0.22854734
170ADRBK10.22509452
171CDK90.21924469
172CSNK1A10.21405217
173KIT0.21078088
174IGF1R0.20426931

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.90572735
2Protein export_Homo sapiens_hsa030606.78829045
3Sulfur metabolism_Homo sapiens_hsa009203.53819172
4Other glycan degradation_Homo sapiens_hsa005113.01858995
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.73870610
6Nicotine addiction_Homo sapiens_hsa050332.55944012
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.41252141
8N-Glycan biosynthesis_Homo sapiens_hsa005102.08024501
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07255911
10Gastric acid secretion_Homo sapiens_hsa049712.04140750
11Phototransduction_Homo sapiens_hsa047441.98840969
12Long-term potentiation_Homo sapiens_hsa047201.98374621
13Sphingolipid metabolism_Homo sapiens_hsa006001.97346241
14Insulin secretion_Homo sapiens_hsa049111.92159943
15Folate biosynthesis_Homo sapiens_hsa007901.79380273
16Circadian rhythm_Homo sapiens_hsa047101.75867396
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67515188
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65198925
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62448586
20Synaptic vesicle cycle_Homo sapiens_hsa047211.60408169
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56545842
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.50249468
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.50175631
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47012773
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46568238
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46462988
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46400464
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44903377
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.40920760
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39238398
31Dopaminergic synapse_Homo sapiens_hsa047281.39222686
32Bile secretion_Homo sapiens_hsa049761.36904603
33Histidine metabolism_Homo sapiens_hsa003401.35368073
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35042714
35ABC transporters_Homo sapiens_hsa020101.33904281
36Hippo signaling pathway_Homo sapiens_hsa043901.30884160
37Vibrio cholerae infection_Homo sapiens_hsa051101.30445774
38ECM-receptor interaction_Homo sapiens_hsa045121.30444069
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30418008
40Dilated cardiomyopathy_Homo sapiens_hsa054141.28958075
41Adherens junction_Homo sapiens_hsa045201.28172072
42Salivary secretion_Homo sapiens_hsa049701.27932691
43Axon guidance_Homo sapiens_hsa043601.27641253
44Estrogen signaling pathway_Homo sapiens_hsa049151.27035472
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26267770
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25699314
47Gap junction_Homo sapiens_hsa045401.21917730
48Glioma_Homo sapiens_hsa052141.18564842
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18253487
50Hedgehog signaling pathway_Homo sapiens_hsa043401.15711921
51Oxytocin signaling pathway_Homo sapiens_hsa049211.14803724
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14498315
53Starch and sucrose metabolism_Homo sapiens_hsa005001.14477728
54Renin secretion_Homo sapiens_hsa049241.13919781
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13628284
56Fatty acid elongation_Homo sapiens_hsa000621.13248234
57Phospholipase D signaling pathway_Homo sapiens_hsa040721.12467332
58Linoleic acid metabolism_Homo sapiens_hsa005911.11728670
59Long-term depression_Homo sapiens_hsa047301.11218351
60GnRH signaling pathway_Homo sapiens_hsa049121.08469551
61Arachidonic acid metabolism_Homo sapiens_hsa005901.08465023
62Retinol metabolism_Homo sapiens_hsa008301.07511028
63Selenocompound metabolism_Homo sapiens_hsa004501.06723420
64Tight junction_Homo sapiens_hsa045301.06335721
65Calcium signaling pathway_Homo sapiens_hsa040201.04713252
66Protein digestion and absorption_Homo sapiens_hsa049741.04664068
67Notch signaling pathway_Homo sapiens_hsa043301.03036319
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02503074
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02347780
70Chemical carcinogenesis_Homo sapiens_hsa052041.01884827
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00519457
72ErbB signaling pathway_Homo sapiens_hsa040121.00112194
73Vitamin B6 metabolism_Homo sapiens_hsa007500.99493590
74Taste transduction_Homo sapiens_hsa047420.97915543
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94619427
76Prion diseases_Homo sapiens_hsa050200.93977223
77Tryptophan metabolism_Homo sapiens_hsa003800.93882693
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93101577
79Dorso-ventral axis formation_Homo sapiens_hsa043200.90493145
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90484134
81Lysosome_Homo sapiens_hsa041420.89787639
82Rap1 signaling pathway_Homo sapiens_hsa040150.88627406
83Focal adhesion_Homo sapiens_hsa045100.88367620
84Vitamin digestion and absorption_Homo sapiens_hsa049770.86633828
85Endometrial cancer_Homo sapiens_hsa052130.86545638
86Choline metabolism in cancer_Homo sapiens_hsa052310.86286345
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85208306
88Cocaine addiction_Homo sapiens_hsa050300.84495253
89Lysine degradation_Homo sapiens_hsa003100.81030484
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80253270
91Thyroid cancer_Homo sapiens_hsa052160.79633084
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79144757
93Oxidative phosphorylation_Homo sapiens_hsa001900.79028714
94MicroRNAs in cancer_Homo sapiens_hsa052060.77436179
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77124842
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76156234
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75877268
98Oocyte meiosis_Homo sapiens_hsa041140.75848692
99Arginine biosynthesis_Homo sapiens_hsa002200.73074461
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.71764124
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70758739
102Galactose metabolism_Homo sapiens_hsa000520.70056398
103Nitrogen metabolism_Homo sapiens_hsa009100.66263327
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65382853
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.65179012
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.64778733
107Ether lipid metabolism_Homo sapiens_hsa005650.64391431
108Ras signaling pathway_Homo sapiens_hsa040140.63353988
109Fatty acid metabolism_Homo sapiens_hsa012120.62285081
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61769345
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61570884
112Homologous recombination_Homo sapiens_hsa034400.60694978
113Peroxisome_Homo sapiens_hsa041460.60504176
114Regulation of autophagy_Homo sapiens_hsa041400.60055485
115Inositol phosphate metabolism_Homo sapiens_hsa005620.59617211
116Serotonergic synapse_Homo sapiens_hsa047260.57873203
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57787048
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57313381
119PPAR signaling pathway_Homo sapiens_hsa033200.56927141
120Olfactory transduction_Homo sapiens_hsa047400.56230021
121Proteoglycans in cancer_Homo sapiens_hsa052050.55655868
122Thyroid hormone synthesis_Homo sapiens_hsa049180.54970742
123Amphetamine addiction_Homo sapiens_hsa050310.54766890
124Fanconi anemia pathway_Homo sapiens_hsa034600.53187881
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52492703
126Cardiac muscle contraction_Homo sapiens_hsa042600.52257684
127Tyrosine metabolism_Homo sapiens_hsa003500.52043540
128Complement and coagulation cascades_Homo sapiens_hsa046100.51812397
129Colorectal cancer_Homo sapiens_hsa052100.51100486
130Fatty acid biosynthesis_Homo sapiens_hsa000610.50760260
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49752864
132Renal cell carcinoma_Homo sapiens_hsa052110.49748727
133VEGF signaling pathway_Homo sapiens_hsa043700.48166537
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47527993
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46498185
136Insulin signaling pathway_Homo sapiens_hsa049100.45510676
137Melanogenesis_Homo sapiens_hsa049160.45275555
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44966371
139AMPK signaling pathway_Homo sapiens_hsa041520.44734920
140beta-Alanine metabolism_Homo sapiens_hsa004100.42458672
141Drug metabolism - other enzymes_Homo sapiens_hsa009830.42258250
142Basal cell carcinoma_Homo sapiens_hsa052170.40749614
143Arginine and proline metabolism_Homo sapiens_hsa003300.40569888
144Metabolic pathways_Homo sapiens_hsa011000.40301805
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40257953
146Pancreatic secretion_Homo sapiens_hsa049720.40023376
147Cholinergic synapse_Homo sapiens_hsa047250.38029946
148Prostate cancer_Homo sapiens_hsa052150.36672087
149Type I diabetes mellitus_Homo sapiens_hsa049400.36063687
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35666699
151Alzheimers disease_Homo sapiens_hsa050100.33939409
152Wnt signaling pathway_Homo sapiens_hsa043100.32292108
153Ribosome_Homo sapiens_hsa030100.31412725
154NF-kappa B signaling pathway_Homo sapiens_hsa040640.31326064
155Butanoate metabolism_Homo sapiens_hsa006500.31067298
156Rheumatoid arthritis_Homo sapiens_hsa053230.30660594
157Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30617759
158Collecting duct acid secretion_Homo sapiens_hsa049660.30517671
159Primary bile acid biosynthesis_Homo sapiens_hsa001200.29613631
160Phenylalanine metabolism_Homo sapiens_hsa003600.29490111
161Circadian entrainment_Homo sapiens_hsa047130.28651817
162Purine metabolism_Homo sapiens_hsa002300.27867936
163Steroid biosynthesis_Homo sapiens_hsa001000.27286584
164Morphine addiction_Homo sapiens_hsa050320.27118025
165Glucagon signaling pathway_Homo sapiens_hsa049220.25953734
166Glutamatergic synapse_Homo sapiens_hsa047240.25810353
167RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25673606
168Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25395907
169GABAergic synapse_Homo sapiens_hsa047270.24830226
170Fatty acid degradation_Homo sapiens_hsa000710.23347883
171Type II diabetes mellitus_Homo sapiens_hsa049300.22532789
172Fat digestion and absorption_Homo sapiens_hsa049750.22325304
173cAMP signaling pathway_Homo sapiens_hsa040240.22119609
174Mineral absorption_Homo sapiens_hsa049780.21334187
175Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20127527

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