LRP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)4.64425036
2triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.24940596
3alpha-linolenic acid metabolic process (GO:0036109)4.24225314
4proline biosynthetic process (GO:0006561)4.15007878
5regulation of cholesterol biosynthetic process (GO:0045540)4.03952933
6epithelial cell-cell adhesion (GO:0090136)4.03859076
7sulfur amino acid catabolic process (GO:0000098)4.01249134
8complement activation, alternative pathway (GO:0006957)4.00881098
9negative regulation of fibrinolysis (GO:0051918)3.96395337
10peptidyl-glutamic acid carboxylation (GO:0017187)3.95866830
11protein carboxylation (GO:0018214)3.95866830
12L-phenylalanine metabolic process (GO:0006558)3.95764072
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.95764072
14COPI coating of Golgi vesicle (GO:0048205)3.95315379
15Golgi transport vesicle coating (GO:0048200)3.95315379
16L-phenylalanine catabolic process (GO:0006559)3.94848181
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.94848181
18positive regulation of fatty acid beta-oxidation (GO:0032000)3.85621507
19urea metabolic process (GO:0019627)3.81080545
20urea cycle (GO:0000050)3.81080545
21kynurenine metabolic process (GO:0070189)3.73466113
22proline metabolic process (GO:0006560)3.70961141
23regulation of protein activation cascade (GO:2000257)3.69872947
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.69864998
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.68265556
26regulation of triglyceride catabolic process (GO:0010896)3.68224031
27protein retention in ER lumen (GO:0006621)3.67094854
28aromatic amino acid family catabolic process (GO:0009074)3.64758119
29glyoxylate metabolic process (GO:0046487)3.62931622
30regulation of fibrinolysis (GO:0051917)3.60845414
31low-density lipoprotein particle clearance (GO:0034383)3.59821185
32nitrogen cycle metabolic process (GO:0071941)3.57821118
33regulation of complement activation (GO:0030449)3.52746455
34high-density lipoprotein particle remodeling (GO:0034375)3.51732956
35regulation of cholesterol homeostasis (GO:2000188)3.51381283
36plasma lipoprotein particle clearance (GO:0034381)3.50968643
37negative regulation of fatty acid transport (GO:2000192)3.49275329
38lung epithelium development (GO:0060428)3.48492568
39homocysteine metabolic process (GO:0050667)3.46438269
40lysine metabolic process (GO:0006553)3.45186853
41lysine catabolic process (GO:0006554)3.45186853
42indole-containing compound catabolic process (GO:0042436)3.42284024
43indolalkylamine catabolic process (GO:0046218)3.42284024
44tryptophan catabolic process (GO:0006569)3.42284024
45very-low-density lipoprotein particle assembly (GO:0034379)3.39322027
46cell-substrate junction assembly (GO:0007044)3.38924749
47regulation of fatty acid beta-oxidation (GO:0031998)3.38064498
48triglyceride homeostasis (GO:0070328)3.38039417
49acylglycerol homeostasis (GO:0055090)3.38039417
50regulation of glucose import in response to insulin stimulus (GO:2001273)3.37812359
51amino-acid betaine metabolic process (GO:0006577)3.37548653
52activation of Rac GTPase activity (GO:0032863)3.35127390
53cysteine metabolic process (GO:0006534)3.32978647
54regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.31475525
55reverse cholesterol transport (GO:0043691)3.30356649
56tryptophan metabolic process (GO:0006568)3.26829189
57regulation of apoptotic cell clearance (GO:2000425)3.25268021
58serine family amino acid catabolic process (GO:0009071)3.23482711
59regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.21104476
60planar cell polarity pathway involved in neural tube closure (GO:0090179)3.20812127
61bile acid biosynthetic process (GO:0006699)3.20211316
62phospholipid homeostasis (GO:0055091)3.19871222
63semaphorin-plexin signaling pathway (GO:0071526)3.17827796
64adherens junction assembly (GO:0034333)3.16864887
65cell-substrate adherens junction assembly (GO:0007045)3.15344347
66focal adhesion assembly (GO:0048041)3.15344347
67hemidesmosome assembly (GO:0031581)3.13876648
68positive regulation of lipid catabolic process (GO:0050996)3.13567301
69regulation of cholesterol metabolic process (GO:0090181)3.12448083
70phospholipid efflux (GO:0033700)3.12299753
71bundle of His cell to Purkinje myocyte communication (GO:0086069)3.11979606
72negative regulation of fatty acid biosynthetic process (GO:0045717)3.10121213
73lipoprotein metabolic process (GO:0042157)3.09941163
74basement membrane organization (GO:0071711)3.06802425
75positive regulation of triglyceride metabolic process (GO:0090208)3.06015813
76ethanol oxidation (GO:0006069)3.05514455
77atrioventricular valve morphogenesis (GO:0003181)3.03658474
78negative regulation of sterol transport (GO:0032372)3.03605128
79negative regulation of cholesterol transport (GO:0032375)3.03605128
80plasma lipoprotein particle remodeling (GO:0034369)3.02718131
81protein-lipid complex remodeling (GO:0034368)3.02718131
82macromolecular complex remodeling (GO:0034367)3.02718131
83positive regulation of fatty acid oxidation (GO:0046321)3.01947470
84intestinal absorption (GO:0050892)2.98958435
85NADH metabolic process (GO:0006734)2.96032060
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.94230697
874-hydroxyproline metabolic process (GO:0019471)2.93241539
88bile acid metabolic process (GO:0008206)2.92128044
89regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.91744558
90retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.91311895
91regulation of cholesterol esterification (GO:0010872)2.90750683
92regulation of extracellular matrix disassembly (GO:0010715)2.88752064
93fatty acid beta-oxidation (GO:0006635)2.88150428
94epoxygenase P450 pathway (GO:0019373)2.87891114
95glycine metabolic process (GO:0006544)2.86571238
96glucose 6-phosphate metabolic process (GO:0051156)2.86551082
97cell-cell junction maintenance (GO:0045217)2.85145416
98regulation of cholesterol storage (GO:0010885)2.85137637
99fibrinolysis (GO:0042730)2.84516077
100* cholesterol homeostasis (GO:0042632)2.81227651
101plasma lipoprotein particle assembly (GO:0034377)2.80957267
102fatty acid transmembrane transport (GO:1902001)2.80942066
103positive regulation of triglyceride lipase activity (GO:0061365)2.79548217
104positive regulation of lipoprotein lipase activity (GO:0051006)2.79548217
105* sterol homeostasis (GO:0055092)2.78708990
106valine metabolic process (GO:0006573)2.78579505
107bile acid and bile salt transport (GO:0015721)2.78457311
108negative regulation of lipase activity (GO:0060192)2.78347672
109glutamine family amino acid biosynthetic process (GO:0009084)2.78293414
110regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.76850856
111cellular modified amino acid catabolic process (GO:0042219)2.76743750
112skin morphogenesis (GO:0043589)2.76412960
113paraxial mesoderm development (GO:0048339)2.76317048
114cholesterol efflux (GO:0033344)2.76094007
115regulation of triglyceride metabolic process (GO:0090207)2.76022942
116acetyl-CoA metabolic process (GO:0006084)2.74771421
117alpha-amino acid catabolic process (GO:1901606)2.74615685
118fatty acid oxidation (GO:0019395)2.74604404
119endothelial cell morphogenesis (GO:0001886)2.74435699
120insulin-like growth factor receptor signaling pathway (GO:0048009)2.73259968
121regulation of sequestering of triglyceride (GO:0010889)2.73084631
1222-oxoglutarate metabolic process (GO:0006103)2.73063798
123positive regulation of extracellular matrix organization (GO:1903055)2.72184576
124regulation of plasminogen activation (GO:0010755)2.72010328
125intestinal cholesterol absorption (GO:0030299)2.71989463
126regulation of extracellular matrix organization (GO:1903053)2.71165312
127protein-lipid complex assembly (GO:0065005)2.69590926
128carnitine metabolic process (GO:0009437)2.69018544
129tyrosine metabolic process (GO:0006570)2.68416026
130negative regulation of cell size (GO:0045792)2.66928962
131linoleic acid metabolic process (GO:0043651)2.66858031
132lipid oxidation (GO:0034440)2.66818336
133renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.64690287
134negative regulation of fatty acid metabolic process (GO:0045922)2.62319488
135positive regulation of triglyceride biosynthetic process (GO:0010867)2.61965819
136regulation of bile acid biosynthetic process (GO:0070857)2.61717355
137apoptotic cell clearance (GO:0043277)2.59404572
138aromatic amino acid family metabolic process (GO:0009072)2.59281517
139regulation of triglyceride biosynthetic process (GO:0010866)2.56167069
140cellular amino acid catabolic process (GO:0009063)2.54399665
141establishment of apical/basal cell polarity (GO:0035089)2.51091722
142biotin metabolic process (GO:0006768)2.50779154
143plasma lipoprotein particle organization (GO:0071827)2.46638192
144endothelial cell chemotaxis (GO:0035767)2.46484266
145branching involved in salivary gland morphogenesis (GO:0060445)2.45777403
146diacylglycerol metabolic process (GO:0046339)2.45316177
147regulation of mammary gland epithelial cell proliferation (GO:0033599)2.44435327
148negative regulation of lipid transport (GO:0032369)2.43738908
149* branching involved in mammary gland duct morphogenesis (GO:0060444)2.42607270
150ethanol metabolic process (GO:0006067)2.40674750
151positive regulation of steroid metabolic process (GO:0045940)2.39687441
152maternal placenta development (GO:0001893)2.39453971
153protein-lipid complex subunit organization (GO:0071825)2.38987904
154activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38424849
155renal system development (GO:0072001)2.37044231
156cellular response to epidermal growth factor stimulus (GO:0071364)2.36602055
157low-density lipoprotein particle remodeling (GO:0034374)2.35174200
158receptor catabolic process (GO:0032801)2.34249623
159gap junction assembly (GO:0016264)2.33727594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.85467211
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.15817390
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.04234970
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.86004928
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.68229242
6* LXR_22158963_ChIP-Seq_LIVER_Mouse4.23462964
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.18705881
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.09817170
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.96721299
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.74668586
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.65060857
12CLOCK_20551151_ChIP-Seq_293T_Human2.57110167
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36106159
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.32622153
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31172466
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30663139
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25703780
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03975906
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.00274930
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.95937443
21ZNF263_19887448_ChIP-Seq_K562_Human1.91978829
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.83239575
23TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76662994
24* KDM2B_26808549_Chip-Seq_K562_Human1.67624212
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64589840
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62742806
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.61319591
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57782467
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57351291
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55956728
31MYC_22102868_ChIP-Seq_BL_Human1.54858699
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53628928
33* ELK3_25401928_ChIP-Seq_HUVEC_Human1.53395531
34* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50470659
35VDR_21846776_ChIP-Seq_THP-1_Human1.50134868
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47468285
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47432978
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.47373833
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45057208
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44279930
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.43976568
42* FOXA2_19822575_ChIP-Seq_HepG2_Human1.43199531
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42403424
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40350666
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39565760
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.39397010
47KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.39397010
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.39397010
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36567282
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35642024
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.33569428
52SMC4_20622854_ChIP-Seq_HELA_Human1.33403925
53CREB1_26743006_Chip-Seq_LNCaP_Human1.32985333
54TBX20_22080862_ChIP-Seq_HEART_Mouse1.32541619
55TBX20_22328084_ChIP-Seq_HEART_Mouse1.32541619
56* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31523855
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.30766490
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30245993
59P68_20966046_ChIP-Seq_HELA_Human1.29874642
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29813365
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27177880
62* CDX2_20551321_ChIP-Seq_CACO-2_Human1.26135033
63LXR_22292898_ChIP-Seq_THP-1_Human1.26105189
64* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24705551
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23985391
66TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.23505651
67* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23384498
68* GATA6_25053715_ChIP-Seq_YYC3_Human1.23112393
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23027742
70GATA4_25053715_ChIP-Seq_YYC3_Human1.21396780
71* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21071074
72* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20966262
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20615462
74ATF3_27146783_Chip-Seq_COLON_Human1.19181224
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19064371
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18967695
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17080151
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16277031
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16157556
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11665490
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.10055097
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.09907671
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.08277062
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05474897
85* HNF4A_19822575_ChIP-Seq_HepG2_Human1.05006952
86* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04842933
87* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04677234
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04669376
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04576143
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04129033
91TCF7_22412390_ChIP-Seq_EML_Mouse1.03481993
92CTCF_27219007_Chip-Seq_Bcells_Human1.02724112
93P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02571280
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02478399
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01739660
96BP1_19119308_ChIP-ChIP_Hs578T_Human1.01240086
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01081128
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00609354
99AR_21909140_ChIP-Seq_LNCAP_Human1.00026963
100* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99082661
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98692079
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97916623
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97916623
104* RUNX1_27514584_Chip-Seq_MCF-7_Human0.97791541
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97635283
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97504104
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97080261
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96664649
109KDM2B_26808549_Chip-Seq_JURKAT_Human0.95819337
110EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95352766
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95212978
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.94823303
113GATA2_21666600_ChIP-Seq_HMVEC_Human0.94301232
114* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94107474
115NCOR1_26117541_ChIP-Seq_K562_Human0.93278502
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93195399
117TP53_22127205_ChIP-Seq_IMR90_Human0.91189216
118* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89344953
119* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88980042
120CJUN_26792858_Chip-Seq_BT549_Human0.88186049
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86897350
122* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84795650
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84542874
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.83629539
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83173475
126TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83035839
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82899922
128* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82178313
129* KDM2B_26808549_Chip-Seq_DND41_Human0.81746741
130BRD4_25478319_ChIP-Seq_HGPS_Human0.79633721
131* UBF1/2_26484160_Chip-Seq_HMECs_Human0.79616851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.21510666
2MP0005360_urolithiasis4.09557910
3MP0003705_abnormal_hypodermis_morpholog3.91941174
4MP0005085_abnormal_gallbladder_physiolo3.44093648
5MP0005365_abnormal_bile_salt3.39782559
6MP0008438_abnormal_cutaneous_collagen3.11533762
7MP0003252_abnormal_bile_duct2.77114749
8MP0005275_abnormal_skin_tensile2.33510088
9MP0009840_abnormal_foam_cell2.23705013
10MP0004272_abnormal_basement_membrane2.18742095
11* MP0010329_abnormal_lipoprotein_level2.13676343
12MP0008875_abnormal_xenobiotic_pharmacok2.11358500
13MP0005409_darkened_coat_color2.10973915
14MP0003191_abnormal_cellular_cholesterol2.10281668
15MP0004858_abnormal_nervous_system2.06091366
16MP0005670_abnormal_white_adipose2.04093979
17MP0010368_abnormal_lymphatic_system1.99841616
18MP0003806_abnormal_nucleotide_metabolis1.88921573
19MP0003566_abnormal_cell_adhesion1.86866363
20MP0005058_abnormal_lysosome_morphology1.78480365
21MP0002089_abnormal_postnatal_growth/wei1.71893193
22MP0005083_abnormal_biliary_tract1.68213356
23MP0000751_myopathy1.62865729
24MP0000678_abnormal_parathyroid_gland1.60088843
25MP0002060_abnormal_skin_morphology1.56330265
26MP0009780_abnormal_chondrocyte_physiolo1.52985994
27MP0001666_abnormal_nutrient_absorption1.49199655
28MP0004782_abnormal_surfactant_physiolog1.45349096
29MP0004185_abnormal_adipocyte_glucose1.44998169
30MP0005666_abnormal_adipose_tissue1.44996357
31MP0000003_abnormal_adipose_tissue1.43355197
32MP0002877_abnormal_melanocyte_morpholog1.43169738
33* MP0000609_abnormal_liver_physiology1.42521305
34MP0002254_reproductive_system_inflammat1.40973560
35MP0009053_abnormal_anal_canal1.35137341
36MP0010234_abnormal_vibrissa_follicle1.32583974
37MP0005023_abnormal_wound_healing1.32379369
38MP0010352_gastrointestinal_tract_polyps1.29083261
39MP0004264_abnormal_extraembryonic_tissu1.28505991
40MP0003279_aneurysm1.27700896
41MP0002796_impaired_skin_barrier1.25108496
42MP0001849_ear_inflammation1.22930649
43MP0004019_abnormal_vitamin_homeostasis1.22856930
44MP0003123_paternal_imprinting1.22184321
45MP0002138_abnormal_hepatobiliary_system1.21495812
46MP0005503_abnormal_tendon_morphology1.20989077
47MP0005248_abnormal_Harderian_gland1.20207681
48MP0005332_abnormal_amino_acid1.19192394
49MP0001661_extended_life_span1.18983113
50* MP0002118_abnormal_lipid_homeostasis1.16875801
51MP0003300_gastrointestinal_ulcer1.16469215
52MP0003283_abnormal_digestive_organ1.14889022
53MP0005319_abnormal_enzyme/_coenzyme1.12964762
54MP0005076_abnormal_cell_differentiation1.12682841
55MP0010030_abnormal_orbit_morphology1.09037528
56MP0000534_abnormal_ureter_morphology1.08607468
57MP0000462_abnormal_digestive_system1.08424548
58MP0005257_abnormal_intraocular_pressure1.07143638
59MP0004233_abnormal_muscle_weight1.06724476
60MP0003942_abnormal_urinary_system1.06295517
61MP0003453_abnormal_keratinocyte_physiol1.05815352
62MP0000767_abnormal_smooth_muscle1.03047361
63MP0001958_emphysema1.01720100
64MP0000579_abnormal_nail_morphology1.00708717
65MP0003941_abnormal_skin_development0.98304109
66MP0000858_altered_metastatic_potential0.98190956
67* MP0002896_abnormal_bone_mineralization0.97228092
68MP0005375_adipose_tissue_phenotype0.95488167
69MP0003045_fibrosis0.94199887
70MP0004130_abnormal_muscle_cell0.92711913
71MP0001348_abnormal_lacrimal_gland0.92072072
72MP0000733_abnormal_muscle_development0.91887306
73MP0003315_abnormal_perineum_morphology0.91477844
74MP0004084_abnormal_cardiac_muscle0.91420679
75MP0010630_abnormal_cardiac_muscle0.90184975
76MP0000598_abnormal_liver_morphology0.89468781
77MP0001730_embryonic_growth_arrest0.88946276
78MP0003115_abnormal_respiratory_system0.88182283
79MP0002837_dystrophic_cardiac_calcinosis0.87476336
80MP0000013_abnormal_adipose_tissue0.86778701
81MP0002168_other_aberrant_phenotype0.86608856
82MP0009384_cardiac_valve_regurgitation0.86433990
83MP0009643_abnormal_urine_homeostasis0.85849522
84MP0009278_abnormal_bone_marrow0.85183017
85MP0005501_abnormal_skin_physiology0.84350440
86MP0001243_abnormal_dermal_layer0.82267879
87MP0006138_congestive_heart_failure0.82051192
88MP0002970_abnormal_white_adipose0.80530706
89MP0000537_abnormal_urethra_morphology0.80224736
90MP0002249_abnormal_larynx_morphology0.79327152
91MP0001915_intracranial_hemorrhage0.78942840
92MP0000477_abnormal_intestine_morphology0.77533359
93MP0003868_abnormal_feces_composition0.77454390
94MP0005451_abnormal_body_composition0.76635068
95MP0002697_abnormal_eye_size0.76565056
96MP0000750_abnormal_muscle_regeneration0.75488902
97MP0009115_abnormal_fat_cell0.75048378
98MP0002098_abnormal_vibrissa_morphology0.74951970
99* MP0002086_abnormal_extraembryonic_tissu0.74832585
100MP0002932_abnormal_joint_morphology0.74575034
101MP0003195_calcinosis0.74450722
102MP0008260_abnormal_autophagy0.73772366
103MP0003385_abnormal_body_wall0.73770433
104MP0002128_abnormal_blood_circulation0.73310146
105MP0005623_abnormal_meninges_morphology0.73115102
106MP0005330_cardiomyopathy0.73059685
107MP0003329_amyloid_beta_deposits0.72415870
108MP0003828_pulmonary_edema0.71828258
109MP0009672_abnormal_birth_weight0.71271942
110MP0000762_abnormal_tongue_morphology0.70411103
111MP0005647_abnormal_sex_gland0.70325421
112MP0000467_abnormal_esophagus_morphology0.69778566
113MP0004087_abnormal_muscle_fiber0.68287019
114MP0001879_abnormal_lymphatic_vessel0.67987304
115MP0002092_abnormal_eye_morphology0.67591893
116MP0001216_abnormal_epidermal_layer0.67020588
117MP0000538_abnormal_urinary_bladder0.66857863
118* MP0001614_abnormal_blood_vessel0.66433406
119MP0010771_integument_phenotype0.65893517
120MP0009931_abnormal_skin_appearance0.65885649
121MP0003172_abnormal_lysosome_physiology0.65884187
122MP0002108_abnormal_muscle_morphology0.65751841
123MP0005334_abnormal_fat_pad0.65176271
124MP0003091_abnormal_cell_migration0.65174556
125MP0002971_abnormal_brown_adipose0.64345629
126MP0003567_abnormal_fetal_cardiomyocyte0.63744286
127MP0002282_abnormal_trachea_morphology0.63599940
128* MP0004197_abnormal_fetal_growth/weight/0.62940851
129* MP0002925_abnormal_cardiovascular_devel0.62386844
130* MP0005508_abnormal_skeleton_morphology0.61037779
131MP0005220_abnormal_exocrine_pancreas0.60681110
132MP0002111_abnormal_tail_morphology0.59918114
133MP0002269_muscular_atrophy0.59753448
134MP0009763_increased_sensitivity_to0.59455225
135MP0000377_abnormal_hair_follicle0.59057753

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.87016805
2Intrahepatic cholestasis (HP:0001406)4.09694748
3Complement deficiency (HP:0004431)4.07213450
4Xanthomatosis (HP:0000991)3.99324558
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.91419626
6Protrusio acetabuli (HP:0003179)3.78310606
7Right ventricular cardiomyopathy (HP:0011663)3.47670928
8Increased connective tissue (HP:0009025)3.30723435
9Premature rupture of membranes (HP:0001788)3.24317546
10Ankle contracture (HP:0006466)3.21352115
11Abnormality of complement system (HP:0005339)3.21311016
12Flat acetabular roof (HP:0003180)3.19608335
13Cerebral aneurysm (HP:0004944)3.10459961
14Hypoalphalipoproteinemia (HP:0003233)3.09728053
15Broad metatarsal (HP:0001783)3.08983361
16Atrophic scars (HP:0001075)3.08612327
17Broad face (HP:0000283)3.07838448
18Myocardial infarction (HP:0001658)3.04578666
19Shallow orbits (HP:0000586)3.02478368
20Hyperacusis (HP:0010780)3.00460638
21Hypobetalipoproteinemia (HP:0003563)2.98382471
22Prolonged partial thromboplastin time (HP:0003645)2.96493377
23Hyperlipoproteinemia (HP:0010980)2.94254675
24Esophageal varix (HP:0002040)2.91000718
25Hypolipoproteinemia (HP:0010981)2.87802645
26Epidermoid cyst (HP:0200040)2.87570424
27Abnormality of aromatic amino acid family metabolism (HP:0004338)2.86670557
28Abnormality of glutamine family amino acid metabolism (HP:0010902)2.75133206
29Joint hemorrhage (HP:0005261)2.74275260
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.71797361
31Abnormality of carpal bone ossification (HP:0006257)2.70889671
32Abnormality of the common coagulation pathway (HP:0010990)2.61896580
33Peritonitis (HP:0002586)2.61487227
34Hyperglycinuria (HP:0003108)2.61279481
35Asymmetry of the thorax (HP:0001555)2.60805219
36Hyperammonemia (HP:0001987)2.59077276
37Distal lower limb amyotrophy (HP:0008944)2.55318523
38Hypercholesterolemia (HP:0003124)2.53433494
39Hypoglycemic coma (HP:0001325)2.52711666
40Vertebral compression fractures (HP:0002953)2.48528734
41Distal upper limb amyotrophy (HP:0007149)2.47584968
42Upper limb amyotrophy (HP:0009129)2.47584968
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.43684062
44Abnormal ossification of hand bones (HP:0005921)2.42357944
45Systemic lupus erythematosus (HP:0002725)2.37881842
46* Hemorrhage of the eye (HP:0011885)2.37580034
47Advanced eruption of teeth (HP:0006288)2.36818376
48Arterial tortuosity (HP:0005116)2.35944185
49Bronchomalacia (HP:0002780)2.35730259
50Pterygium (HP:0001059)2.34940897
51Alopecia of scalp (HP:0002293)2.34856337
52Ketosis (HP:0001946)2.31907994
53Mitral valve prolapse (HP:0001634)2.31743819
54Abnormality of the intrinsic pathway (HP:0010989)2.30094940
55Cardiovascular calcification (HP:0011915)2.29066064
56Lymphangioma (HP:0100764)2.28699950
57Skin nodule (HP:0200036)2.27335980
58Short nail (HP:0001799)2.27155197
59Type 1 muscle fiber predominance (HP:0003803)2.27098714
60Abnormality of glycine metabolism (HP:0010895)2.22767528
61Abnormality of serine family amino acid metabolism (HP:0010894)2.22767528
62Abnormality of the Achilles tendon (HP:0005109)2.22319898
63Thin bony cortex (HP:0002753)2.20504599
64Vascular tortuosity (HP:0004948)2.19693691
65Fragile skin (HP:0001030)2.19202252
66Turricephaly (HP:0000262)2.17582966
67Nephritis (HP:0000123)2.17438130
68Aortic dissection (HP:0002647)2.17182927
69Hepatocellular carcinoma (HP:0001402)2.12288669
70Ventricular tachycardia (HP:0004756)2.12149031
71Vascular calcification (HP:0004934)2.10991471
72Abnormality of pyrimidine metabolism (HP:0004353)2.09878960
73Glomerulonephritis (HP:0000099)2.07173472
74Focal segmental glomerulosclerosis (HP:0000097)2.05503122
75Abnormality of the acetabulum (HP:0003170)2.04926707
76Achilles tendon contracture (HP:0001771)2.03537796
77Premature skin wrinkling (HP:0100678)2.02820268
78Wormian bones (HP:0002645)2.02753028
79Fat malabsorption (HP:0002630)2.02610068
80Coxa vara (HP:0002812)2.02223659
81Biconcave vertebral bodies (HP:0004586)2.00975781
82Ulnar bowing (HP:0003031)2.00094765
83Blue sclerae (HP:0000592)1.99715540
84Milia (HP:0001056)1.99453465
85Hyperglycinemia (HP:0002154)1.99399251
86Pseudobulbar signs (HP:0002200)1.97297463
87Rectal prolapse (HP:0002035)1.97215051
88* Aneurysm (HP:0002617)1.96157509
89Abnormal hand bone ossification (HP:0010660)1.95905134
90Stridor (HP:0010307)1.95835880
91Bladder diverticulum (HP:0000015)1.95140070
92Trismus (HP:0000211)1.95093197
93Spinal rigidity (HP:0003306)1.95062380
94Follicular hyperkeratosis (HP:0007502)1.94331243
95Abnormality of the distal phalanges of the toes (HP:0010182)1.93658178
96Abnormality of the distal phalanx of the thumb (HP:0009617)1.91969693
97Mildly elevated creatine phosphokinase (HP:0008180)1.91428141
98Abnormality of proline metabolism (HP:0010907)1.91204785
99Hydroxyprolinuria (HP:0003080)1.91204785
100Aortic aneurysm (HP:0004942)1.91117350
101Polycythemia (HP:0001901)1.90707087
102Abnormality of fatty-acid metabolism (HP:0004359)1.88674753
103Disproportionate tall stature (HP:0001519)1.88554065
104Spastic diplegia (HP:0001264)1.86030530
105Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84283265
106Ectopia lentis (HP:0001083)1.82671760
107Malnutrition (HP:0004395)1.82413469
108Obstructive sleep apnea (HP:0002870)1.82318449
109Abnormality of nucleobase metabolism (HP:0010932)1.81754726
110Distal lower limb muscle weakness (HP:0009053)1.81345428
111Cervical subluxation (HP:0003308)1.81193520
112Hyporeflexia of lower limbs (HP:0002600)1.80515658
113Glomerulosclerosis (HP:0000096)1.79633161
114Neonatal short-limb short stature (HP:0008921)1.79456876
115Abnormal cartilage morphology (HP:0002763)1.78629195
116Menorrhagia (HP:0000132)1.76851018
117J-shaped sella turcica (HP:0002680)1.75230043
118Ketoacidosis (HP:0001993)1.74602942
119Hematochezia (HP:0002573)1.74122313
120Mitral stenosis (HP:0001718)1.73047383
121Renovascular hypertension (HP:0100817)1.72973785
122Natal tooth (HP:0000695)1.72939606
123Back pain (HP:0003418)1.72867556
124Hypoplastic ischia (HP:0003175)1.72013920
125Renal duplication (HP:0000075)1.71842227
126Cupped ribs (HP:0000887)1.71361732
127Acanthosis nigricans (HP:0000956)1.70769314
128Neonatal death (HP:0003811)1.70094398
129Slender build (HP:0001533)1.69552372
130Mitral regurgitation (HP:0001653)1.69488980
131Abnormality of dentin (HP:0010299)1.68725342
132Conjugated hyperbilirubinemia (HP:0002908)1.68651344
133Abnormality of the 4th metacarpal (HP:0010012)1.68462709
134Aplasia involving bones of the upper limbs (HP:0009823)1.68313671
135Aplasia of the phalanges of the hand (HP:0009802)1.68313671
136Aplasia involving bones of the extremities (HP:0009825)1.68313671
137Abnormality of purine metabolism (HP:0004352)1.67692609
138Abnormality of methionine metabolism (HP:0010901)1.67677933
139Osteolytic defects of the hand bones (HP:0009699)1.67634497
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.67634497
141Abnormal vertebral ossification (HP:0100569)1.66333453
142Muscle fiber splitting (HP:0003555)1.66188292
143Abnormal tarsal ossification (HP:0008369)1.65177533
144Abdominal distention (HP:0003270)1.64598623
145Hyperglycemia (HP:0003074)1.64461118
146Wrist flexion contracture (HP:0001239)1.64158220
147Increased mean platelet volume (HP:0011877)1.63932752
148Growth hormone excess (HP:0000845)1.62608406
149Hypertriglyceridemia (HP:0002155)1.61773754
150Abnormal delivery (HP:0001787)1.61376601
151Reticulocytosis (HP:0001923)1.60863612
152Ankyloglossia (HP:0010296)1.59953767
153Hand muscle atrophy (HP:0009130)1.57773423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.72762524
2EPHA23.53871195
3LATS13.51780549
4TRIB33.32930293
5ERN13.21793304
6PKN23.05124624
7SMG12.72279651
8CDK122.61504432
9TGFBR22.47234043
10TTN2.37734820
11RIPK12.19112197
12FGFR42.08870137
13TIE12.03838958
14EEF2K2.02927705
15BCKDK1.99224267
16PDGFRA1.90029282
17PTK61.89085283
18CAMK1D1.85484371
19PAK41.72427437
20MAP3K101.70422956
21ICK1.65641734
22EPHB21.59702716
23DDR21.58543913
24EPHB11.55998690
25MST1R1.44319134
26FLT31.34699084
27STK38L1.33726519
28BMX1.30955381
29MTOR1.27975694
30STK31.27302564
31LATS21.21763159
32CDK61.15102429
33MET1.15002165
34PRPF4B1.14894478
35CAMK1G1.14849588
36KDR1.12753901
37PTK21.09628656
38TESK11.07628460
39INSRR1.07604357
40FER1.02401252
41MAP2K31.02186926
42NTRK11.01088644
43EPHA30.99527285
44PAK20.90908369
45TAOK30.89081838
46MAP3K30.89041695
47STK100.87255373
48LMTK20.87094712
49NEK90.86822532
50MAPK150.86028112
51NME20.84693360
52RPS6KB20.83699859
53IRAK30.82461944
54MAPK110.80230539
55FGFR20.79441491
56ERBB40.78254722
57PRKD30.77185059
58PDGFRB0.75951944
59PRKAA20.74374283
60TTK0.74050839
61CDK80.73244414
62CDK40.73022159
63ERBB20.71975065
64FRK0.71843911
65MARK20.71605730
66WNK40.71219981
67PDPK10.70458969
68LRRK20.70235332
69TGFBR10.69807513
70TRPM70.69693041
71DMPK0.69229758
72FGFR30.66684481
73RPS6KA20.66471834
74FGFR10.65159764
75MAP3K70.63200062
76TYK20.61623897
77CSF1R0.60834362
78CDK70.60139868
79MAPKAPK30.59917967
80GSK3A0.59738755
81SCYL20.57717301
82CHUK0.57642845
83CSK0.56595138
84STK40.56525584
85IRAK20.56315739
86MATK0.54130785
87TYRO30.53416768
88MAP2K20.51315300
89DYRK1B0.50178831
90JAK10.49933491
91MAP3K20.48219382
92BRD40.48206331
93PDK30.47465438
94PDK40.47465438
95PRKD10.47138541
96MAP3K80.45901060
97MAP3K10.43080376
98PIK3CG0.42890212
99STK380.42308213
100JAK20.41742042
101ILK0.41714073
102RPS6KA40.39686065
103AKT20.39495010
104NEK20.39400128
105MAP3K60.39392070
106RPS6KL10.38973937
107TAOK10.38478828
108PRKG20.37379667
109PRKAA10.36984837
110PRKD20.36730452
111CDK90.36602217
112HIPK20.36185717
113TAOK20.35622796
114CDC42BPA0.33740314
115PDK20.32948314
116ARAF0.31963672
117KSR20.31829763
118PRKCI0.31241219
119RET0.30523496
120MYLK0.29128592
121MELK0.28377442
122MAPK10.27909908
123MAPKAPK20.27907644
124CAMK40.27131765
125PIM20.27022352
126WNK10.26377557
127ABL20.26004465
128RPS6KA10.26000537
129RPS6KC10.25849954
130MAP2K10.22925992
131MAP3K110.22343908
132TESK20.21721053
133SRC0.21374473
134NME10.21315499
135RPS6KA60.20585734

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.11165468
2Nitrogen metabolism_Homo sapiens_hsa009102.76652647
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.70658933
4Fatty acid degradation_Homo sapiens_hsa000712.67189157
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.60549674
6Complement and coagulation cascades_Homo sapiens_hsa046102.52182374
7Arginine biosynthesis_Homo sapiens_hsa002202.45663091
8Tryptophan metabolism_Homo sapiens_hsa003802.35507844
9PPAR signaling pathway_Homo sapiens_hsa033202.23320384
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20311896
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.07775965
12Fatty acid metabolism_Homo sapiens_hsa012122.03315723
13Staphylococcus aureus infection_Homo sapiens_hsa051501.94399779
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94397366
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83037972
16Propanoate metabolism_Homo sapiens_hsa006401.82521400
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80991631
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80409833
19Caffeine metabolism_Homo sapiens_hsa002321.80362561
20Lysine degradation_Homo sapiens_hsa003101.71946272
21Fat digestion and absorption_Homo sapiens_hsa049751.63857352
22beta-Alanine metabolism_Homo sapiens_hsa004101.58512548
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55091347
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55008662
25Peroxisome_Homo sapiens_hsa041461.53886207
26Selenocompound metabolism_Homo sapiens_hsa004501.50863957
27Chemical carcinogenesis_Homo sapiens_hsa052041.49585226
28Histidine metabolism_Homo sapiens_hsa003401.46737864
29ECM-receptor interaction_Homo sapiens_hsa045121.43969443
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39226041
31Starch and sucrose metabolism_Homo sapiens_hsa005001.34966264
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.34944604
33Bile secretion_Homo sapiens_hsa049761.33536442
34Butanoate metabolism_Homo sapiens_hsa006501.33485923
35Phenylalanine metabolism_Homo sapiens_hsa003601.31173094
36Fatty acid biosynthesis_Homo sapiens_hsa000611.24152932
37Retinol metabolism_Homo sapiens_hsa008301.22924575
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.21312099
39Carbon metabolism_Homo sapiens_hsa012001.21284786
40Pyruvate metabolism_Homo sapiens_hsa006201.17792563
41Tyrosine metabolism_Homo sapiens_hsa003501.14670734
42ABC transporters_Homo sapiens_hsa020101.14313208
43Biosynthesis of amino acids_Homo sapiens_hsa012301.12105280
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10879174
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07094292
46Thyroid cancer_Homo sapiens_hsa052161.03784174
47N-Glycan biosynthesis_Homo sapiens_hsa005101.02978958
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02767016
49Adherens junction_Homo sapiens_hsa045201.02562227
50Vitamin digestion and absorption_Homo sapiens_hsa049771.00126366
51One carbon pool by folate_Homo sapiens_hsa006700.99846404
52Arginine and proline metabolism_Homo sapiens_hsa003300.90565887
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90038933
54Protein digestion and absorption_Homo sapiens_hsa049740.87272238
55Small cell lung cancer_Homo sapiens_hsa052220.85602248
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83496867
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83381171
58Focal adhesion_Homo sapiens_hsa045100.82242048
59Insulin resistance_Homo sapiens_hsa049310.80788075
60Notch signaling pathway_Homo sapiens_hsa043300.79534554
61Glucagon signaling pathway_Homo sapiens_hsa049220.78225648
62Thyroid hormone synthesis_Homo sapiens_hsa049180.77761307
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.77733650
64Glycerolipid metabolism_Homo sapiens_hsa005610.77708695
65Bladder cancer_Homo sapiens_hsa052190.77326659
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77206003
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76628283
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75939512
69Tight junction_Homo sapiens_hsa045300.74077641
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73362846
71Endometrial cancer_Homo sapiens_hsa052130.72369564
72Sulfur metabolism_Homo sapiens_hsa009200.72313046
73Non-small cell lung cancer_Homo sapiens_hsa052230.71522773
74Basal cell carcinoma_Homo sapiens_hsa052170.71510114
75Fatty acid elongation_Homo sapiens_hsa000620.71173563
76Amoebiasis_Homo sapiens_hsa051460.68539152
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68369061
78Folate biosynthesis_Homo sapiens_hsa007900.68200977
79Pancreatic cancer_Homo sapiens_hsa052120.65701980
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.63622987
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.62687005
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62592458
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61480378
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.60026126
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59574761
86mTOR signaling pathway_Homo sapiens_hsa041500.58430618
87Sulfur relay system_Homo sapiens_hsa041220.57891960
88VEGF signaling pathway_Homo sapiens_hsa043700.56323912
89Pentose phosphate pathway_Homo sapiens_hsa000300.55630475
90Proteoglycans in cancer_Homo sapiens_hsa052050.54647903
91Galactose metabolism_Homo sapiens_hsa000520.54194528
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.54147049
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53993648
94Dilated cardiomyopathy_Homo sapiens_hsa054140.53259513
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53183123
96Renin-angiotensin system_Homo sapiens_hsa046140.51086615
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50508913
98Glutathione metabolism_Homo sapiens_hsa004800.50504468
99Axon guidance_Homo sapiens_hsa043600.50151020
100AMPK signaling pathway_Homo sapiens_hsa041520.49686521
101ErbB signaling pathway_Homo sapiens_hsa040120.49584625
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49525710
103Renal cell carcinoma_Homo sapiens_hsa052110.49219255
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.47204934
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47176883
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44604506
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44121519
108Prostate cancer_Homo sapiens_hsa052150.43713425
109MicroRNAs in cancer_Homo sapiens_hsa052060.43281808
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42206396
111Steroid biosynthesis_Homo sapiens_hsa001000.41675435
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40676361
113Fructose and mannose metabolism_Homo sapiens_hsa000510.39891079
114Chronic myeloid leukemia_Homo sapiens_hsa052200.37170989
115Hippo signaling pathway_Homo sapiens_hsa043900.36719338
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33638882
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33141899
118Vitamin B6 metabolism_Homo sapiens_hsa007500.32259811
119Prion diseases_Homo sapiens_hsa050200.31753393
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31696039
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31673305
122TGF-beta signaling pathway_Homo sapiens_hsa043500.28729952
123Other glycan degradation_Homo sapiens_hsa005110.27338412
124Acute myeloid leukemia_Homo sapiens_hsa052210.27140415
125Toxoplasmosis_Homo sapiens_hsa051450.26344080
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.26150558
127Insulin signaling pathway_Homo sapiens_hsa049100.24291663

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