LRP5L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 methylation (GO:0051568)4.49307263
2histone H3-K4 trimethylation (GO:0080182)4.42205301
3negative regulation of erythrocyte differentiation (GO:0045647)4.32599364
4positive regulation of gamma-delta T cell activation (GO:0046645)4.02791023
5negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.02586377
6negative regulation of granulocyte differentiation (GO:0030853)3.93586592
7regulation of granulocyte differentiation (GO:0030852)3.77294416
8positive regulation of granulocyte differentiation (GO:0030854)3.76193667
9negative regulation of cAMP-mediated signaling (GO:0043951)3.67921829
10detection of bacterium (GO:0016045)3.64351357
11mannose metabolic process (GO:0006013)3.56764596
12regulation of gamma-delta T cell activation (GO:0046643)3.49996219
13regulation of type B pancreatic cell apoptotic process (GO:2000674)3.48979877
14detection of other organism (GO:0098543)3.44720569
15regulation of gamma-delta T cell differentiation (GO:0045586)3.42159567
16L-alpha-amino acid transmembrane transport (GO:1902475)3.39126990
17regulation of B cell apoptotic process (GO:0002902)3.36315200
18response to lipoprotein particle (GO:0055094)3.33191487
193-UTR-mediated mRNA stabilization (GO:0070935)3.30796022
20response to peptidoglycan (GO:0032494)3.28849928
21dosage compensation (GO:0007549)3.22690034
22diaphragm development (GO:0060539)3.18524405
23pyrimidine nucleoside salvage (GO:0043097)3.13871390
24pyrimidine-containing compound salvage (GO:0008655)3.13871390
25histone H3-K36 demethylation (GO:0070544)3.12910150
26exogenous drug catabolic process (GO:0042738)3.12747309
27B cell receptor signaling pathway (GO:0050853)3.12188799
28Arp2/3 complex-mediated actin nucleation (GO:0034314)3.10827943
29cellular response to ethanol (GO:0071361)3.08434163
30drug catabolic process (GO:0042737)3.01238992
31detection of biotic stimulus (GO:0009595)3.00144322
32regulation of B cell receptor signaling pathway (GO:0050855)2.98885516
33peptidyl-lysine trimethylation (GO:0018023)2.98571963
34regulation of mRNA catabolic process (GO:0061013)2.92265367
35arginine catabolic process (GO:0006527)2.90008844
36positive regulation of protein homooligomerization (GO:0032464)2.86249238
37detection of external biotic stimulus (GO:0098581)2.84093356
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.83833841
39L-phenylalanine catabolic process (GO:0006559)2.83833841
40histone demethylation (GO:0016577)2.82356878
41positive regulation of Rap GTPase activity (GO:0032854)2.80902333
42regulation of mitochondrial translation (GO:0070129)2.79892054
43protein demethylation (GO:0006482)2.78823737
44protein dealkylation (GO:0008214)2.78823737
45positive regulation of B cell differentiation (GO:0045579)2.78483406
46antigen processing and presentation of endogenous antigen (GO:0019883)2.77413610
47histone H3-K9 demethylation (GO:0033169)2.75424825
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74162027
49positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.73312010
50negative regulation of interleukin-12 production (GO:0032695)2.73032933
51histone H4-K16 acetylation (GO:0043984)2.72355871
52negative regulation of protein oligomerization (GO:0032460)2.72335400
53histone lysine methylation (GO:0034968)2.72191544
54histone lysine demethylation (GO:0070076)2.70437201
55negative regulation of innate immune response (GO:0045824)2.69472478
56regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.69045521
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.64875497
58toxin transport (GO:1901998)2.64722371
59negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.64620700
60negative regulation of calcium ion transport into cytosol (GO:0010523)2.64103924
61retrograde transport, vesicle recycling within Golgi (GO:0000301)2.62805578
62RNA destabilization (GO:0050779)2.62769456
63histone H3-K9 modification (GO:0061647)2.62259524
64response to host (GO:0075136)2.61393383
65response to host defenses (GO:0052200)2.61393383
66response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.61393383
67positive regulation of mRNA catabolic process (GO:0061014)2.60934374
68response to host immune response (GO:0052572)2.60789761
69response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60789761
70negative regulation of bone resorption (GO:0045779)2.58816338
71histone H4-K8 acetylation (GO:0043982)2.57777966
72histone H4-K5 acetylation (GO:0043981)2.57777966
73regulation of dendritic cell antigen processing and presentation (GO:0002604)2.55874019
74negative thymic T cell selection (GO:0045060)2.55516328
75nitric oxide mediated signal transduction (GO:0007263)2.55429513
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53970025
77TOR signaling (GO:0031929)2.53770778
78establishment of protein localization to Golgi (GO:0072600)2.53585525
79negative regulation of cell size (GO:0045792)2.53360660
80macrophage activation involved in immune response (GO:0002281)2.51379012
81germinal center formation (GO:0002467)2.48939250
82regulation of monocyte differentiation (GO:0045655)2.48385405
83regulation of energy homeostasis (GO:2000505)2.48264632
84negative regulation of interleukin-6 production (GO:0032715)2.45368662
85peptidyl-lysine methylation (GO:0018022)2.45291404
86protein targeting to Golgi (GO:0000042)2.44018574
87erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.43915985
88L-phenylalanine metabolic process (GO:0006558)2.43915985
89actin nucleation (GO:0045010)2.43579974
90skeletal muscle organ development (GO:0060538)2.41476758
91response to muramyl dipeptide (GO:0032495)2.41279445
92N-acetylneuraminate metabolic process (GO:0006054)2.41006375
93negative regulation of glycoprotein biosynthetic process (GO:0010561)2.40830250
94positive regulation by symbiont of host defense response (GO:0052509)2.39756018
95modulation by symbiont of host defense response (GO:0052031)2.39756018
96modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.39756018
97modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.39756018
98positive regulation by organism of defense response of other organism involved in symbiotic interact2.39756018
99modulation by symbiont of host immune response (GO:0052553)2.39756018
100respiratory chain complex IV assembly (GO:0008535)2.38993526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.35551404
2VDR_21846776_ChIP-Seq_THP-1_Human3.33151544
3MYC_22102868_ChIP-Seq_BL_Human3.25890366
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.11731993
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49988886
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43711818
7SCL_19346495_ChIP-Seq_HPC-7_Human2.41596963
8E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.39400552
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.35721628
10VDR_24763502_ChIP-Seq_THP-1_Human2.26307731
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.22633888
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16786889
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16417592
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.11391830
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10067998
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.04834384
17TCF7_22412390_ChIP-Seq_EML_Mouse1.99504317
18SPI1_23547873_ChIP-Seq_NB4_Human1.96648421
19MAF_26560356_Chip-Seq_TH2_Human1.94182444
20UTX_26944678_Chip-Seq_JUKART_Human1.91087047
21MYB_26560356_Chip-Seq_TH2_Human1.89766342
22KDM2B_26808549_Chip-Seq_DND41_Human1.86501484
23* MAF_26560356_Chip-Seq_TH1_Human1.85354376
24* KDM5A_27292631_Chip-Seq_BREAST_Human1.83372409
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82887508
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.80827535
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78847414
28GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.77774602
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75928702
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75584395
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71566650
32SPI1_23127762_ChIP-Seq_K562_Human1.71234658
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.70925190
34MYB_26560356_Chip-Seq_TH1_Human1.70435411
35CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70142409
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.69182768
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.68259391
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67331030
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65607735
40RUNX_20019798_ChIP-Seq_JUKART_Human1.63022359
41SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.61732586
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60672342
43BCOR_27268052_Chip-Seq_Bcells_Human1.59536089
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59522008
45LXR_22292898_ChIP-Seq_THP-1_Human1.58182743
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.56808047
47TFEB_21752829_ChIP-Seq_HELA_Human1.54810367
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54382572
49P68_20966046_ChIP-Seq_HELA_Human1.51452909
50CIITA_25753668_ChIP-Seq_RAJI_Human1.50092886
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.46735158
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46026157
53PKCTHETA_26484144_Chip-Seq_BREAST_Human1.45410885
54SMC4_20622854_ChIP-Seq_HELA_Human1.44013686
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40751779
56GATA3_27048872_Chip-Seq_THYMUS_Human1.40537300
57BCL6_27268052_Chip-Seq_Bcells_Human1.39393148
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37694007
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37482044
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.37077556
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36234283
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35119391
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33357248
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.32540323
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.31144740
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30553753
67E2F1_20622854_ChIP-Seq_HELA_Human1.27721949
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27561992
69P300_27268052_Chip-Seq_Bcells_Human1.27491662
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26877391
71GATA1_19941826_ChIP-Seq_K562_Human1.26484523
72GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26405896
73SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.26234820
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25724877
75GATA3_26560356_Chip-Seq_TH2_Human1.25199496
76NCOR1_26117541_ChIP-Seq_K562_Human1.24759990
77MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24750846
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22574380
79PHF8_20622854_ChIP-Seq_HELA_Human1.22195963
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19294687
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19146052
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.17689874
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.15522985
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14465156
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13321037
86IRF8_21731497_ChIP-ChIP_J774_Mouse1.10701729
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10361141
88* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09460100
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08805504
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07615620
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07158297
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07149899
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06010072
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05822290
95GABP_19822575_ChIP-Seq_HepG2_Human1.04498340
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04409501
97RARB_24833708_ChIP-Seq_LIVER_Mouse1.02844122
98* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01259018
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00858089
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98943222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003172_abnormal_lysosome_physiology2.96005441
2MP0009278_abnormal_bone_marrow2.65399839
3MP0002139_abnormal_hepatobiliary_system2.57032334
4MP0003763_abnormal_thymus_physiology2.39713319
5MP0002396_abnormal_hematopoietic_system2.38519824
6MP0003195_calcinosis2.37521509
7MP0003436_decreased_susceptibility_to2.31835264
8MP0001835_abnormal_antigen_presentation2.23244659
9MP0004043_abnormal_pH_regulation2.19077820
10MP0003646_muscle_fatigue2.13960424
11MP0002132_abnormal_respiratory_system2.13485782
12MP0003303_peritoneal_inflammation2.09643839
13MP0002009_preneoplasia2.09028470
14MP0005058_abnormal_lysosome_morphology2.03617816
15MP0005645_abnormal_hypothalamus_physiol2.01293067
16MP0000685_abnormal_immune_system1.92025231
17MP0009840_abnormal_foam_cell1.88023093
18MP0005387_immune_system_phenotype1.83819130
19MP0001790_abnormal_immune_system1.83819130
20MP0002138_abnormal_hepatobiliary_system1.82179551
21MP0001800_abnormal_humoral_immune1.77228732
22MP0001873_stomach_inflammation1.73389245
23MP0004808_abnormal_hematopoietic_stem1.73368439
24MP0002419_abnormal_innate_immunity1.71649155
25MP0005310_abnormal_salivary_gland1.69026390
26MP0008260_abnormal_autophagy1.67795676
27MP0006082_CNS_inflammation1.64485806
28MP0002693_abnormal_pancreas_physiology1.63901332
29MP0003300_gastrointestinal_ulcer1.59918093
30MP0002723_abnormal_immune_serum1.56430494
31MP0002420_abnormal_adaptive_immunity1.55678750
32MP0004233_abnormal_muscle_weight1.55378896
33MP0002405_respiratory_system_inflammati1.55016022
34MP0001764_abnormal_homeostasis1.54672840
35MP0001819_abnormal_immune_cell1.53430320
36MP0005025_abnormal_response_to1.53367727
37MP0003283_abnormal_digestive_organ1.52908377
38MP0002452_abnormal_antigen_presenting1.49028524
39MP0005000_abnormal_immune_tolerance1.48023037
40MP0000689_abnormal_spleen_morphology1.42557646
41MP0002398_abnormal_bone_marrow1.41191642
42MP0000013_abnormal_adipose_tissue1.36431868
43MP0001545_abnormal_hematopoietic_system1.35681251
44MP0005397_hematopoietic_system_phenotyp1.35681251
45MP0003045_fibrosis1.31592623
46MP0002166_altered_tumor_susceptibility1.31563356
47MP0003191_abnormal_cellular_cholesterol1.31170668
48MP0005464_abnormal_platelet_physiology1.30825642
49MP0003724_increased_susceptibility_to1.29686048
50MP0003183_abnormal_peptide_metabolism1.28905917
51MP0000716_abnormal_immune_system1.27075870
52MP0001845_abnormal_inflammatory_respons1.26027313
53MP0005076_abnormal_cell_differentiation1.24895811
54MP0005379_endocrine/exocrine_gland_phen1.20232464
55MP0000609_abnormal_liver_physiology1.19463526
56MP0002722_abnormal_immune_system1.18809563
57MP0003656_abnormal_erythrocyte_physiolo1.18494842
58MP0000703_abnormal_thymus_morphology1.17458007
59MP0010329_abnormal_lipoprotein_level1.15340908
60MP0009333_abnormal_splenocyte_physiolog1.15171700
61MP0005220_abnormal_exocrine_pancreas1.14795162
62MP0002163_abnormal_gland_morphology1.14100997
63MP0001853_heart_inflammation1.13027174
64MP0008058_abnormal_DNA_repair1.12867055
65MP0008469_abnormal_protein_level1.12332360
66MP0008057_abnormal_DNA_replication1.11918840
67MP0001944_abnormal_pancreas_morphology1.09739658
68MP0005671_abnormal_response_to1.09525724
69MP0002429_abnormal_blood_cell1.09374430
70MP0009785_altered_susceptibility_to1.08666361
71MP0008877_abnormal_DNA_methylation1.08532507
72MP0003786_premature_aging1.04847070
73MP0010155_abnormal_intestine_physiology1.03142050
74MP0002928_abnormal_bile_duct1.02995712
75MP0004510_myositis1.02781559
76MP0003787_abnormal_imprinting0.99249015
77MP0004947_skin_inflammation0.98689563
78MP0008995_early_reproductive_senescence0.98559383
79MP0009764_decreased_sensitivity_to0.98118979
80MP0000003_abnormal_adipose_tissue0.97889040
81MP0004858_abnormal_nervous_system0.97252729
82MP0003252_abnormal_bile_duct0.95647560
83MP0002970_abnormal_white_adipose0.92631692
84MP0000383_abnormal_hair_follicle0.92476657
85MP0006035_abnormal_mitochondrial_morpho0.92236032
86MP0009643_abnormal_urine_homeostasis0.90872648
87MP0002837_dystrophic_cardiac_calcinosis0.89935398
88MP0003866_abnormal_defecation0.88963360
89MP0005319_abnormal_enzyme/_coenzyme0.88871819
90MP0002078_abnormal_glucose_homeostasis0.87978091
91MP0000598_abnormal_liver_morphology0.86888641
92MP0009115_abnormal_fat_cell0.86680332
93MP0002118_abnormal_lipid_homeostasis0.86152763
94MP0005451_abnormal_body_composition0.85731402
95MP0002971_abnormal_brown_adipose0.85031630
96MP0001533_abnormal_skeleton_physiology0.84943775
97MP0002148_abnormal_hypersensitivity_rea0.84435514
98MP0005167_abnormal_blood-brain_barrier0.82771231
99MP0010678_abnormal_skin_adnexa0.78821775
100MP0001270_distended_abdomen0.78388679

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)4.79261313
2Abnormality of the fingertips (HP:0001211)3.97983034
3Hypoglycemic seizures (HP:0002173)3.81642881
4Hypoglycemic coma (HP:0001325)3.58271748
5Intestinal fistula (HP:0100819)3.55288414
6Abnormal delayed hypersensitivity skin test (HP:0002963)3.42029217
7Sparse lateral eyebrow (HP:0005338)3.22138313
8Anal stenosis (HP:0002025)3.21427770
9Lip pit (HP:0100267)3.21365511
10Dysostosis multiplex (HP:0000943)3.17148018
11Thoracic kyphosis (HP:0002942)3.15662628
12Lower limb hyperreflexia (HP:0002395)3.03962165
13Ketoacidosis (HP:0001993)2.96702846
14Abnormality of mucopolysaccharide metabolism (HP:0011020)2.95836313
15Abnormality of polysaccharide metabolism (HP:0011012)2.95836313
16Abnormality of glycosaminoglycan metabolism (HP:0004371)2.95836313
17Mucopolysacchariduria (HP:0008155)2.92987573
18Urinary glycosaminoglycan excretion (HP:0003541)2.92987573
19Hyperinsulinemic hypoglycemia (HP:0000825)2.83633262
20Symptomatic seizures (HP:0011145)2.82967001
21Recurrent abscess formation (HP:0002722)2.81698012
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.78786225
23Elevated erythrocyte sedimentation rate (HP:0003565)2.73855114
24Myositis (HP:0100614)2.68828383
25Recurrent bacterial skin infections (HP:0005406)2.62177062
26Recurrent gram-negative bacterial infections (HP:0005420)2.59618571
27Colitis (HP:0002583)2.58886609
28Abnormality of aromatic amino acid family metabolism (HP:0004338)2.56229489
29Recurrent fungal infections (HP:0002841)2.53304758
30Prominent metopic ridge (HP:0005487)2.50421463
31Eczematoid dermatitis (HP:0000976)2.49963414
32Hyperglycemia (HP:0003074)2.49832697
33Abnormality of T cell physiology (HP:0011840)2.47372587
34Panhypogammaglobulinemia (HP:0003139)2.47095773
35Abnormality of the thoracic spine (HP:0100711)2.45444182
36Increased CSF protein (HP:0002922)2.45435447
37Prolonged bleeding time (HP:0003010)2.43386559
38Ketosis (HP:0001946)2.42580600
39Inflammation of the large intestine (HP:0002037)2.39853888
40Abnormality of the pancreatic islet cells (HP:0006476)2.39683204
41Abnormality of endocrine pancreas physiology (HP:0012093)2.39683204
42Gastrointestinal inflammation (HP:0004386)2.37781079
43Increased IgE level (HP:0003212)2.35780292
44Stomatitis (HP:0010280)2.33884785
45Ureteral stenosis (HP:0000071)2.32004330
46Late onset (HP:0003584)2.31926436
47Mediastinal lymphadenopathy (HP:0100721)2.28994190
48Urethral obstruction (HP:0000796)2.28895902
49Acute hepatic failure (HP:0006554)2.28139552
50Orchitis (HP:0100796)2.27784094
51Abnormality of transition element cation homeostasis (HP:0011030)2.21206406
52Increased serum ferritin (HP:0003281)2.20983671
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20934504
54Pustule (HP:0200039)2.20501295
55Dysmetric saccades (HP:0000641)2.19277819
56Meningitis (HP:0001287)2.16652980
57Fatigue (HP:0012378)2.12287296
58Abnormality of the metopic suture (HP:0005556)2.11774994
59Ureteral obstruction (HP:0006000)2.10929524
60Recurrent cutaneous fungal infections (HP:0011370)2.07362598
61Chronic mucocutaneous candidiasis (HP:0002728)2.07362598
62Obstructive lung disease (HP:0006536)2.06978232
63Chronic obstructive pulmonary disease (HP:0006510)2.06978232
64Testicular atrophy (HP:0000029)2.05694762
65Hypochromic anemia (HP:0001931)2.03835991
66Abnormality of iron homeostasis (HP:0011031)1.99001129
67Abnormality of macrophages (HP:0004311)1.97511709
68Large for gestational age (HP:0001520)1.96569388
69Encephalitis (HP:0002383)1.95011011
70Testicular neoplasm (HP:0010788)1.90204396
71Retrobulbar optic neuritis (HP:0100654)1.89982512
72Optic neuritis (HP:0100653)1.89982512
73Episodic fever (HP:0001954)1.86723494
74Hyperthyroidism (HP:0000836)1.86288846
75Recurrent viral infections (HP:0004429)1.85921990
76Polydipsia (HP:0001959)1.84661194
77Abnormal drinking behavior (HP:0030082)1.84661194
78Autoimmune hemolytic anemia (HP:0001890)1.84625760
79Septate vagina (HP:0001153)1.80731569
80Short 5th finger (HP:0009237)1.80072466
81Recurrent skin infections (HP:0001581)1.79722845
82Prolonged partial thromboplastin time (HP:0003645)1.79185882
83Nuclear cataract (HP:0100018)1.75279918
84Agammaglobulinemia (HP:0004432)1.75037598
85Vasculitis (HP:0002633)1.74948016
86Acute lymphatic leukemia (HP:0006721)1.73924124
87Asymmetry of the thorax (HP:0001555)1.73530970
88Abnormality of T cells (HP:0002843)1.72333975
89Viral hepatitis (HP:0006562)1.72030338
90Gingivitis (HP:0000230)1.71320310
91Abnormality of DNA repair (HP:0003254)1.70713038
92Generalized aminoaciduria (HP:0002909)1.69049334
93Progressive external ophthalmoplegia (HP:0000590)1.68585026
94Microvesicular hepatic steatosis (HP:0001414)1.68428965
95Abnormality of the peritoneum (HP:0002585)1.66987418
96Granulocytopenia (HP:0001913)1.66949096
97Abnormality of the periventricular white matter (HP:0002518)1.66596823
98Sandal gap (HP:0001852)1.66490283
99Disproportionate short-trunk short stature (HP:0003521)1.66463485
100Insulin-resistant diabetes mellitus (HP:0000831)1.66204714

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN12.81919551
2TNK22.50127091
3PRPF4B2.49742596
4STK242.47210350
5MAP4K12.32641650
6MAP2K32.20090906
7MAP3K22.14945897
8CDK122.13655646
9EEF2K2.10854469
10WNK42.08702804
11FRK2.06728767
12PASK2.04598634
13TAOK32.01055594
14MAP3K31.94338204
15JAK31.87689082
16IRAK31.79847926
17IRAK41.77219355
18TRIB31.75748248
19MAP3K141.63621962
20TRPM71.59421223
21IRAK21.57891819
22RIPK41.57621004
23MAP3K71.50761937
24BMX1.48929235
25IKBKE1.44657234
26IKBKB1.38037432
27CAMK1G1.35922800
28IRAK11.33758572
29FES1.32329615
30KIT1.27970158
31TBK11.25645553
32SIK21.25593836
33BTK1.22232508
34MAP2K61.21813027
35CSF1R1.21213509
36CHUK1.16434188
37SIK11.14698629
38HIPK21.11273552
39TYK21.09817406
40BMPR21.08462990
41MAP3K11.08222674
42BLK1.06813179
43MAPK111.06242974
44MAP3K111.05938484
45HCK1.05375329
46GRK61.04996148
47DAPK21.04173032
48RPS6KC11.03371209
49RPS6KL11.03371209
50FGFR41.00542797
51WNK10.99141345
52CAMK1D0.98586039
53FGFR30.98220920
54MAP3K130.97174974
55SYK0.96383224
56RPS6KA60.96339224
57TEC0.95560887
58MARK20.95487191
59STK390.91463193
60SIK30.90008323
61TAOK10.88981809
62RPS6KB20.87964615
63ZAP700.83721573
64FGR0.82975616
65PINK10.81492856
66PDK10.81398277
67NLK0.78670185
68MAP4K20.77562775
69PRKAA20.71741341
70PDPK10.71672787
71MTOR0.69667803
72ITK0.67458830
73PRKAA10.66790016
74PTK2B0.66172621
75PKN20.65928255
76CAMKK20.65378430
77LCK0.64466354
78CAMK10.62703172
79MARK30.56352212
80CAMK40.56312117
81RET0.55376790
82YES10.55308963
83CAMKK10.54842814
84CDK40.54096650
85STK40.53394469
86TAOK20.53363269
87CDC42BPA0.53167628
88PIM10.52429662
89CSK0.52079407
90RPS6KA20.51195815
91PRKD20.50770408
92LYN0.50569340
93MAP3K100.49205567
94TRIM280.45823966
95JAK10.44640542
96TLK10.44348798
97MATK0.44208280
98CDK90.42719493
99PRKCQ0.41240243
100SGK30.40907303

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.03099412
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.78355344
3B cell receptor signaling pathway_Homo sapiens_hsa046622.25457364
4Acute myeloid leukemia_Homo sapiens_hsa052212.23237484
5Type I diabetes mellitus_Homo sapiens_hsa049402.19462488
6ABC transporters_Homo sapiens_hsa020101.94195404
7Osteoclast differentiation_Homo sapiens_hsa043801.80104930
8Regulation of autophagy_Homo sapiens_hsa041401.79692812
9mTOR signaling pathway_Homo sapiens_hsa041501.78781707
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77369926
11Type II diabetes mellitus_Homo sapiens_hsa049301.77171809
12Leishmaniasis_Homo sapiens_hsa051401.72286394
13Lysine degradation_Homo sapiens_hsa003101.55079960
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.52651202
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52114442
16Insulin resistance_Homo sapiens_hsa049311.47730318
17T cell receptor signaling pathway_Homo sapiens_hsa046601.40740443
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.40511002
19AMPK signaling pathway_Homo sapiens_hsa041521.40012915
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39602495
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.39428851
22Primary immunodeficiency_Homo sapiens_hsa053401.35703025
23Arginine biosynthesis_Homo sapiens_hsa002201.29235694
24Non-small cell lung cancer_Homo sapiens_hsa052231.28694795
25TNF signaling pathway_Homo sapiens_hsa046681.26721237
26Staphylococcus aureus infection_Homo sapiens_hsa051501.24945427
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20609110
28Complement and coagulation cascades_Homo sapiens_hsa046101.19337656
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19103537
30Prolactin signaling pathway_Homo sapiens_hsa049171.18150786
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18018029
32Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16760205
33Lysosome_Homo sapiens_hsa041421.15927789
34FoxO signaling pathway_Homo sapiens_hsa040681.14270271
35Tuberculosis_Homo sapiens_hsa051521.12190208
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08401765
37Hepatitis B_Homo sapiens_hsa051611.08359168
38Chronic myeloid leukemia_Homo sapiens_hsa052201.06875416
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06585591
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04290813
41Inositol phosphate metabolism_Homo sapiens_hsa005621.03103804
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.00448995
43Influenza A_Homo sapiens_hsa051640.99958052
44Herpes simplex infection_Homo sapiens_hsa051680.99922096
45Butanoate metabolism_Homo sapiens_hsa006500.99849161
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99191196
47Measles_Homo sapiens_hsa051620.94307355
48Legionellosis_Homo sapiens_hsa051340.94016068
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.93904155
50mRNA surveillance pathway_Homo sapiens_hsa030150.92291375
51Toxoplasmosis_Homo sapiens_hsa051450.91908391
52Insulin signaling pathway_Homo sapiens_hsa049100.91012479
53Pertussis_Homo sapiens_hsa051330.89107243
54Hepatitis C_Homo sapiens_hsa051600.88060038
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.87375915
56N-Glycan biosynthesis_Homo sapiens_hsa005100.85207394
57Glucagon signaling pathway_Homo sapiens_hsa049220.82632898
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81259720
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81024691
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80111374
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.79285689
62Collecting duct acid secretion_Homo sapiens_hsa049660.79160254
63Insulin secretion_Homo sapiens_hsa049110.79083538
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.78669951
65VEGF signaling pathway_Homo sapiens_hsa043700.76890939
66Autoimmune thyroid disease_Homo sapiens_hsa053200.76028455
67Graft-versus-host disease_Homo sapiens_hsa053320.75275885
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74323179
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74287924
70Allograft rejection_Homo sapiens_hsa053300.74117793
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72133475
72Viral carcinogenesis_Homo sapiens_hsa052030.71411085
73Chemokine signaling pathway_Homo sapiens_hsa040620.71237223
74Selenocompound metabolism_Homo sapiens_hsa004500.71066015
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69354027
76Pancreatic cancer_Homo sapiens_hsa052120.66342320
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65523358
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.65159980
79Fructose and mannose metabolism_Homo sapiens_hsa000510.64533709
80Shigellosis_Homo sapiens_hsa051310.62596330
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60844902
82Choline metabolism in cancer_Homo sapiens_hsa052310.59637708
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59329937
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.58252067
85Notch signaling pathway_Homo sapiens_hsa043300.57894835
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57540310
87Asthma_Homo sapiens_hsa053100.55280337
88Dorso-ventral axis formation_Homo sapiens_hsa043200.54771953
89Platelet activation_Homo sapiens_hsa046110.54465655
90African trypanosomiasis_Homo sapiens_hsa051430.48201141
91Prostate cancer_Homo sapiens_hsa052150.47357874
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46936472
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46802963
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46648058
95Endometrial cancer_Homo sapiens_hsa052130.46633359
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44493305
97Epstein-Barr virus infection_Homo sapiens_hsa051690.42591629
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41833734
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41525461
100GnRH signaling pathway_Homo sapiens_hsa049120.40529685

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