LRP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.12498295
2regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.06514251
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.98934132
4vocalization behavior (GO:0071625)4.94111496
5neuron cell-cell adhesion (GO:0007158)4.91671933
6synaptic vesicle maturation (GO:0016188)4.84170972
7locomotory exploration behavior (GO:0035641)4.82203584
8nuclear pore complex assembly (GO:0051292)4.71076698
9synaptic vesicle exocytosis (GO:0016079)4.55752627
10protein localization to synapse (GO:0035418)4.54155790
11* layer formation in cerebral cortex (GO:0021819)4.51289760
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.46396807
13regulation of glutamate receptor signaling pathway (GO:1900449)4.42659883
14dendritic spine morphogenesis (GO:0060997)4.34716780
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.26772879
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.24549346
17DNA unwinding involved in DNA replication (GO:0006268)4.22471199
18nuclear pore organization (GO:0006999)4.16860420
19postsynaptic membrane organization (GO:0001941)4.07854368
20glutamate secretion (GO:0014047)4.07016808
21neuron recognition (GO:0008038)4.04942856
22proline transport (GO:0015824)4.04302688
23regulation of synaptic vesicle exocytosis (GO:2000300)3.97233364
24DNA topological change (GO:0006265)3.93457516
25mitotic sister chromatid cohesion (GO:0007064)3.93085959
26axonal fasciculation (GO:0007413)3.90722730
27dendrite morphogenesis (GO:0048813)3.87758610
28glutamate receptor signaling pathway (GO:0007215)3.83860572
29exploration behavior (GO:0035640)3.83566057
30regulation of centriole replication (GO:0046599)3.77403557
31synaptic transmission, glutamatergic (GO:0035249)3.76230138
32neurotransmitter secretion (GO:0007269)3.70926164
33neurotransmitter-gated ion channel clustering (GO:0072578)3.69822964
34central nervous system projection neuron axonogenesis (GO:0021952)3.66769552
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.63359630
36positive regulation of synapse maturation (GO:0090129)3.57899915
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.51704567
38gamma-aminobutyric acid transport (GO:0015812)3.49552122
39regulation of synapse structural plasticity (GO:0051823)3.47860683
40presynaptic membrane assembly (GO:0097105)3.47447032
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42624144
42pyrimidine nucleobase catabolic process (GO:0006208)3.42330668
43cell migration in hindbrain (GO:0021535)3.41928744
44cerebellar granule cell differentiation (GO:0021707)3.40369272
45pore complex assembly (GO:0046931)3.36740804
46auditory behavior (GO:0031223)3.36614809
47sister chromatid segregation (GO:0000819)3.33797055
48neuron-neuron synaptic transmission (GO:0007270)3.33615793
49regulation of neuronal synaptic plasticity (GO:0048168)3.31766964
50regulation of synaptic vesicle transport (GO:1902803)3.31597837
51positive regulation of synapse assembly (GO:0051965)3.30828790
52cerebellar Purkinje cell differentiation (GO:0021702)3.30137340
53establishment of nucleus localization (GO:0040023)3.29426745
54positive regulation of membrane potential (GO:0045838)3.27448303
55regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.25391406
56DNA replication checkpoint (GO:0000076)3.24032106
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22734337
58* positive regulation of dendritic spine morphogenesis (GO:0061003)3.21695297
59presynaptic membrane organization (GO:0097090)3.21231956
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20373244
61cerebral cortex radially oriented cell migration (GO:0021799)3.19961920
62DNA strand elongation involved in DNA replication (GO:0006271)3.19808134
63mitotic sister chromatid segregation (GO:0000070)3.19747139
64pre-miRNA processing (GO:0031054)3.19194457
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.18424501
66innervation (GO:0060384)3.17378936
67regulation of translational fidelity (GO:0006450)3.16316265
68synaptic vesicle endocytosis (GO:0048488)3.16267066
69DNA replication initiation (GO:0006270)3.13967179
70synapse assembly (GO:0007416)3.13097841
71mitotic chromosome condensation (GO:0007076)3.12657369
72regulation of postsynaptic membrane potential (GO:0060078)3.12263256
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10557412
74DNA strand elongation (GO:0022616)3.10236928
75* regulation of dendritic spine morphogenesis (GO:0061001)3.08189605
76neuronal action potential propagation (GO:0019227)3.07811477
77response to auditory stimulus (GO:0010996)3.07211267
78protein localization to kinetochore (GO:0034501)3.06927098
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06854536
80long-term memory (GO:0007616)3.06488346
81regulation of centrosome cycle (GO:0046605)3.05154799
82regulation of centrosome duplication (GO:0010824)3.03958397
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02265394
84regulation of synaptic transmission, glutamatergic (GO:0051966)2.99258863
85startle response (GO:0001964)2.95599332
86neurotransmitter transport (GO:0006836)2.94706939
87transmission of nerve impulse (GO:0019226)2.94194626
88cellular potassium ion homeostasis (GO:0030007)2.94016363
89DNA duplex unwinding (GO:0032508)2.93814458
90clathrin coat assembly (GO:0048268)2.92764556
91mechanosensory behavior (GO:0007638)2.92290269
92regulation of synapse maturation (GO:0090128)2.91753351
93DNA geometric change (GO:0032392)2.88703526
94regulation of neurotransmitter secretion (GO:0046928)2.86473529
95negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84748757
96regulation of vesicle fusion (GO:0031338)2.84744109
97central nervous system neuron axonogenesis (GO:0021955)2.84638776
98maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84119746
99gamma-aminobutyric acid signaling pathway (GO:0007214)2.83781324
100glial cell proliferation (GO:0014009)2.83012106
101regulation of synapse assembly (GO:0051963)2.82431554
102cell differentiation in hindbrain (GO:0021533)2.81779033
103regulation of ARF protein signal transduction (GO:0032012)2.81681718
104replication fork processing (GO:0031297)2.81598120
105axon extension (GO:0048675)2.79525395
106spinal cord development (GO:0021510)2.78102632
107membrane depolarization (GO:0051899)2.76006566
108synapse organization (GO:0050808)2.75929977
109behavioral response to nicotine (GO:0035095)2.75392476
110negative regulation of microtubule polymerization (GO:0031115)2.75197680
111peptidyl-tyrosine autophosphorylation (GO:0038083)2.74735882
112regulation of nuclear cell cycle DNA replication (GO:0033262)2.73137370
113regulation of synapse organization (GO:0050807)2.71362834
114membrane depolarization during action potential (GO:0086010)2.70741837
115cochlea development (GO:0090102)2.69591773
116response to histamine (GO:0034776)2.69223373
117protein localization to chromosome, centromeric region (GO:0071459)2.69196103
118cerebellum development (GO:0021549)2.68989047
119regulation of synaptic plasticity (GO:0048167)2.68885569
120nucleobase catabolic process (GO:0046113)2.67556861
121telomere maintenance via semi-conservative replication (GO:0032201)2.67432914
122dendritic spine organization (GO:0097061)2.67068530
123mitotic metaphase plate congression (GO:0007080)2.66200081
124regulation of sister chromatid cohesion (GO:0007063)2.66104551
125long-term synaptic potentiation (GO:0060291)2.65979113
126positive regulation of neurotransmitter secretion (GO:0001956)2.65169497
127learning (GO:0007612)2.65023031
128chromatin remodeling at centromere (GO:0031055)2.64564250
129DNA synthesis involved in DNA repair (GO:0000731)2.64416443
130* regulation of dendritic spine development (GO:0060998)2.64411118
131intraspecies interaction between organisms (GO:0051703)2.64209915
132social behavior (GO:0035176)2.64209915
133* positive regulation of dendritic spine development (GO:0060999)2.63785464
134mitotic nuclear envelope disassembly (GO:0007077)2.62720489
135regulation of DNA endoreduplication (GO:0032875)2.55687891
136CENP-A containing nucleosome assembly (GO:0034080)2.54637557
137heterochromatin organization (GO:0070828)2.52842620
138DNA replication-dependent nucleosome assembly (GO:0006335)2.51138980
139DNA replication-dependent nucleosome organization (GO:0034723)2.51138980
140establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.50867582
141mitochondrion transport along microtubule (GO:0047497)2.50867582
142ATP-dependent chromatin remodeling (GO:0043044)2.50227377
143membrane disassembly (GO:0030397)2.49933516
144nuclear envelope disassembly (GO:0051081)2.49933516
145L-serine metabolic process (GO:0006563)2.48968922
146DNA conformation change (GO:0071103)2.47433185
147protein complex localization (GO:0031503)2.47405596
148positive regulation of cell cycle G2/M phase transition (GO:1902751)2.46805874
149positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.46805874
150establishment of mitochondrion localization (GO:0051654)2.45959176
151kinetochore organization (GO:0051383)2.45455652
152nucleosome disassembly (GO:0006337)2.42418566
153protein-DNA complex disassembly (GO:0032986)2.42418566
154establishment of integrated proviral latency (GO:0075713)2.40543261
155microtubule depolymerization (GO:0007019)2.38043640
156somatic diversification of immune receptors via somatic mutation (GO:0002566)2.38035215
157somatic hypermutation of immunoglobulin genes (GO:0016446)2.38035215
158regulation of histone H3-K9 methylation (GO:0051570)2.37711772
159mitotic recombination (GO:0006312)2.36991466
160DNA replication-independent nucleosome assembly (GO:0006336)2.36866132
161DNA replication-independent nucleosome organization (GO:0034724)2.36866132
162regulation of DNA-dependent DNA replication (GO:0090329)2.36312188
163negative regulation of DNA-dependent DNA replication (GO:2000104)2.33835446
164metaphase plate congression (GO:0051310)2.33549682
165negative regulation of histone methylation (GO:0031061)2.32942413
166chromatin assembly (GO:0031497)2.32228050
167meiotic chromosome segregation (GO:0045132)2.31466130
168chromatin assembly or disassembly (GO:0006333)2.30568089
169hindbrain development (GO:0030902)2.30538450
170mitotic spindle organization (GO:0007052)2.30032179
171dorsal/ventral axis specification (GO:0009950)2.29571207
172regulation of chromosome segregation (GO:0051983)2.28024476
173establishment of monopolar cell polarity (GO:0061162)2.27014308
174establishment or maintenance of monopolar cell polarity (GO:0061339)2.27014308
175DNA strand renaturation (GO:0000733)2.25701998
176sister chromatid cohesion (GO:0007062)2.25321053
177cytoplasmic mRNA processing body assembly (GO:0033962)2.24899343
178non-recombinational repair (GO:0000726)2.24891344
179double-strand break repair via nonhomologous end joining (GO:0006303)2.24891344
180telomere maintenance via recombination (GO:0000722)2.24809848
181histone exchange (GO:0043486)2.24451558
182histone arginine methylation (GO:0034969)2.23930119
183cellular protein complex localization (GO:0034629)2.21137644
184regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.21137120
185spindle checkpoint (GO:0031577)2.16489385
186regulation of RNA export from nucleus (GO:0046831)2.14777934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.19276555
2EZH2_22144423_ChIP-Seq_EOC_Human5.87153773
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.58836700
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.59864591
5GBX2_23144817_ChIP-Seq_PC3_Human3.33234411
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05116786
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88900497
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87624791
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.79604865
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.75495330
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73149190
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.71547540
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70696296
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.69293515
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.67479491
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66941103
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66941103
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50632892
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48142122
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43402248
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42968863
22REST_21632747_ChIP-Seq_MESCs_Mouse2.34449284
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.30176016
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27009333
25* EED_16625203_ChIP-ChIP_MESCs_Mouse2.26466396
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.26003272
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23649140
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16511213
29* EZH2_27294783_Chip-Seq_ESCs_Mouse2.14705213
30DROSHA_22980978_ChIP-Seq_HELA_Human2.14132504
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12372030
32IGF1R_20145208_ChIP-Seq_DFB_Human2.11845595
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10408789
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89980266
35AR_21572438_ChIP-Seq_LNCaP_Human1.88537022
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.86895248
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.82600106
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76066477
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75224586
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.74999910
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74080507
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.73898005
43* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72435474
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67819186
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67537250
46* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.67410550
47* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63547330
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61709477
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61091662
50SMAD4_21799915_ChIP-Seq_A2780_Human1.58905618
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56453890
52EWS_26573619_Chip-Seq_HEK293_Human1.55893278
53TAF15_26573619_Chip-Seq_HEK293_Human1.55499242
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52430004
55ZNF274_21170338_ChIP-Seq_K562_Hela1.50465925
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49847595
57RNF2_27304074_Chip-Seq_NSC_Mouse1.48975376
58P300_19829295_ChIP-Seq_ESCs_Human1.48488742
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.47940746
60AR_21909140_ChIP-Seq_LNCAP_Human1.47280646
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47254717
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.46978384
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46907974
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46366825
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.45516254
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.44915104
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44662502
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41144023
69* RING1B_27294783_Chip-Seq_NPCs_Mouse1.41126509
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40988267
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39899836
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.37331351
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36808379
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33644287
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31304747
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.30698771
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30683425
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.30409205
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30235470
80XRN2_22483619_ChIP-Seq_HELA_Human1.29039256
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28857595
82AHR_22903824_ChIP-Seq_MCF-7_Human1.28383470
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28298255
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27149435
85TTF2_22483619_ChIP-Seq_HELA_Human1.26857736
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.25368265
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25241593
88* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25084936
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25055544
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.24569587
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24391277
92* STAT3_23295773_ChIP-Seq_U87_Human1.24046675
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23779676
94* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22949262
95SOX9_26525672_Chip-Seq_HEART_Mouse1.22359340
96FUS_26573619_Chip-Seq_HEK293_Human1.22050025
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21689472
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21223892
99AR_25329375_ChIP-Seq_VCAP_Human1.20975969
100MYC_18940864_ChIP-ChIP_HL60_Human1.20875408
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20727306
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19685971
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19685971
104* AR_19668381_ChIP-Seq_PC3_Human1.18428271
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17972324
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17923712
107SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17353695
108* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.16948097
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16363255
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14474293
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13580767
112NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12916938
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12218359
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12163371
115* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.11407248
116* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10657067
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09778052
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09602776
119* TCF4_23295773_ChIP-Seq_U87_Human1.09487099
120CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09252112
121* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09085183
122ELK1_19687146_ChIP-ChIP_HELA_Human1.08903561
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08735876
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08632621
125SMAD3_21741376_ChIP-Seq_ESCs_Human1.07349665
126* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07237045
127* KDM2B_26808549_Chip-Seq_K562_Human1.06515582
128* RUNX2_22187159_ChIP-Seq_PCA_Human1.05596700
129TP53_16413492_ChIP-PET_HCT116_Human1.05348544
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04911476
131RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04740254
132NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03970461
133PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01243990
134ETS1_20019798_ChIP-Seq_JURKAT_Human1.00907694
135ER_23166858_ChIP-Seq_MCF-7_Human1.00375940
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00232560
137FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99983848
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99843605
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.99252425
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98562064
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98063327
142HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97719629
143E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95558509
144ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95451791
145EST1_17652178_ChIP-ChIP_JURKAT_Human0.95393529
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94984078
147CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94773912
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93017325
149OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92610315
150ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92339198
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.91642236
152CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90570668
153KDM5A_27292631_Chip-Seq_BREAST_Human0.86407398
154EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.85337339
155CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84722228
156ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83926333
157DCP1A_22483619_ChIP-Seq_HELA_Human0.82422888
158POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.82168948
159NANOG_16153702_ChIP-ChIP_HESCs_Human0.82131465
160ZFX_18555785_ChIP-Seq_MESCs_Mouse0.79326766
161MYC_22102868_ChIP-Seq_BL_Human0.78738813
162POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78663868
163STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.78111647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.09513011
2MP0003880_abnormal_central_pattern3.76079065
3* MP0003635_abnormal_synaptic_transmissio3.48597617
4MP0004270_analgesia3.16584634
5MP0005423_abnormal_somatic_nervous3.03314190
6MP0010094_abnormal_chromosome_stability2.88683444
7* MP0002063_abnormal_learning/memory/cond2.82173577
8MP0008057_abnormal_DNA_replication2.73864630
9MP0000569_abnormal_digit_pigmentation2.67943501
10MP0000778_abnormal_nervous_system2.66211715
11MP0009046_muscle_twitch2.61835481
12MP0009745_abnormal_behavioral_response2.60895703
13MP0003787_abnormal_imprinting2.51954632
14MP0002064_seizures2.45837401
15MP0001968_abnormal_touch/_nociception2.43760078
16MP0002734_abnormal_mechanical_nocicepti2.43002870
17MP0002572_abnormal_emotion/affect_behav2.41350847
18MP0003111_abnormal_nucleus_morphology2.35146887
19MP0001486_abnormal_startle_reflex2.23657298
20MP0002735_abnormal_chemical_nociception2.22316099
21MP0003693_abnormal_embryo_hatching2.19898628
22MP0004957_abnormal_blastocyst_morpholog2.19227687
23MP0002184_abnormal_innervation2.14171221
24MP0008058_abnormal_DNA_repair1.97518257
25MP0003077_abnormal_cell_cycle1.95826364
26MP0009780_abnormal_chondrocyte_physiolo1.88278048
27MP0002557_abnormal_social/conspecific_i1.88186099
28MP0002272_abnormal_nervous_system1.84241928
29MP0002736_abnormal_nociception_after1.83318946
30MP0002733_abnormal_thermal_nociception1.82545852
31MP0001188_hyperpigmentation1.81274833
32MP0005645_abnormal_hypothalamus_physiol1.80155505
33MP0008932_abnormal_embryonic_tissue1.79134553
34MP0003122_maternal_imprinting1.78595954
35MP0002067_abnormal_sensory_capabilities1.78002217
36MP0006276_abnormal_autonomic_nervous1.77281744
37MP0001440_abnormal_grooming_behavior1.75447857
38* MP0004811_abnormal_neuron_physiology1.73308453
39MP0003136_yellow_coat_color1.72487429
40MP0005394_taste/olfaction_phenotype1.72290819
41MP0005499_abnormal_olfactory_system1.72290819
42MP0000566_synostosis1.71020083
43* MP0000955_abnormal_spinal_cord1.69962490
44MP0002234_abnormal_pharynx_morphology1.64138667
45MP0000579_abnormal_nail_morphology1.59990036
46MP0001970_abnormal_pain_threshold1.58074463
47MP0003937_abnormal_limbs/digits/tail_de1.57860990
48MP0008789_abnormal_olfactory_epithelium1.51324360
49* MP0002882_abnormal_neuron_morphology1.50398183
50MP0002102_abnormal_ear_morphology1.48821318
51MP0001501_abnormal_sleep_pattern1.43047631
52MP0004924_abnormal_behavior1.42403770
53MP0005386_behavior/neurological_phenoty1.42403770
54* MP0002152_abnormal_brain_morphology1.39840288
55* MP0008569_lethality_at_weaning1.39544047
56MP0005646_abnormal_pituitary_gland1.38527989
57MP0000631_abnormal_neuroendocrine_gland1.37491478
58MP0004858_abnormal_nervous_system1.37429941
59MP0003121_genomic_imprinting1.35337517
60MP0001984_abnormal_olfaction1.32853700
61MP0001502_abnormal_circadian_rhythm1.30882015
62MP0004885_abnormal_endolymph1.29782980
63MP0003123_paternal_imprinting1.28714472
64MP0002697_abnormal_eye_size1.26352785
65MP0004742_abnormal_vestibular_system1.25015497
66MP0003315_abnormal_perineum_morphology1.24913530
67MP0001293_anophthalmia1.24407639
68MP0001986_abnormal_taste_sensitivity1.24325478
69* MP0003861_abnormal_nervous_system1.24267596
70MP0003879_abnormal_hair_cell1.23370874
71MP0009672_abnormal_birth_weight1.22583971
72MP0002909_abnormal_adrenal_gland1.22579617
73MP0002084_abnormal_developmental_patter1.20220042
74MP0001286_abnormal_eye_development1.19352941
75MP0001529_abnormal_vocalization1.18439311
76* MP0002066_abnormal_motor_capabilities/c1.17970892
77MP0005623_abnormal_meninges_morphology1.17920323
78MP0002085_abnormal_embryonic_tissue1.16372650
79MP0006292_abnormal_olfactory_placode1.15283442
80MP0005551_abnormal_eye_electrophysiolog1.14679486
81MP0000350_abnormal_cell_proliferation1.09577954
82MP0005380_embryogenesis_phenotype1.09407943
83MP0001672_abnormal_embryogenesis/_devel1.09407943
84MP0002938_white_spotting1.08974643
85MP0001730_embryonic_growth_arrest1.08539550
86MP0010234_abnormal_vibrissa_follicle1.07748453
87MP0000428_abnormal_craniofacial_morphol1.06123239
88MP0010030_abnormal_orbit_morphology1.05599926
89MP0003942_abnormal_urinary_system1.04067532
90MP0006072_abnormal_retinal_apoptosis1.01317630
91MP0004133_heterotaxia1.01146971
92MP0002396_abnormal_hematopoietic_system1.00175511
93MP0002092_abnormal_eye_morphology0.99560486
94MP0005076_abnormal_cell_differentiation0.98208445
95MP0002111_abnormal_tail_morphology0.97983666
96MP0003984_embryonic_growth_retardation0.97389659
97MP0002751_abnormal_autonomic_nervous0.97224018
98MP0002752_abnormal_somatic_nervous0.97220827
99MP0001697_abnormal_embryo_size0.97079396
100MP0008007_abnormal_cellular_replicative0.95825963
101MP0002088_abnormal_embryonic_growth/wei0.95020973
102MP0003935_abnormal_craniofacial_develop0.94399002
103MP0009703_decreased_birth_body0.93747014
104MP0002822_catalepsy0.93746785
105MP0003890_abnormal_embryonic-extraembry0.93579623
106MP0001299_abnormal_eye_distance/0.93193989
107MP0000534_abnormal_ureter_morphology0.91724427
108MP0002160_abnormal_reproductive_system0.89046092
109MP0000647_abnormal_sebaceous_gland0.88570724
110MP0010307_abnormal_tumor_latency0.88336284
111MP0003938_abnormal_ear_development0.87687458
112MP0004197_abnormal_fetal_growth/weight/0.87684987
113MP0005187_abnormal_penis_morphology0.87546288
114MP0002080_prenatal_lethality0.87079451
115MP0003634_abnormal_glial_cell0.85901933
116MP0010678_abnormal_skin_adnexa0.84577690
117MP0002653_abnormal_ependyma_morphology0.83583782
118MP0008961_abnormal_basal_metabolism0.82606881
119MP0005409_darkened_coat_color0.81922938
120MP0002638_abnormal_pupillary_reflex0.80072162
121MP0001177_atelectasis0.79706336
122MP0005253_abnormal_eye_physiology0.79552187
123MP0004085_abnormal_heartbeat0.79407815
124MP0000537_abnormal_urethra_morphology0.77305145
125MP0002081_perinatal_lethality0.77236053
126MP0001963_abnormal_hearing_physiology0.75562841
127MP0003631_nervous_system_phenotype0.75334299
128MP0000026_abnormal_inner_ear0.75302741
129MP0003633_abnormal_nervous_system0.74655271
130MP0008877_abnormal_DNA_methylation0.74630349
131MP0004142_abnormal_muscle_tone0.74566564
132MP0003632_abnormal_nervous_system0.72268439
133MP0002233_abnormal_nose_morphology0.70481716
134MP0003119_abnormal_digestive_system0.69761281
135MP0003329_amyloid_beta_deposits0.69648990
136MP0003755_abnormal_palate_morphology0.69193047
137* MP0002069_abnormal_eating/drinking_beha0.68757743
138MP0001943_abnormal_respiration0.67718152
139MP0000049_abnormal_middle_ear0.67046697
140MP0005171_absent_coat_pigmentation0.66822503
141* MP0002082_postnatal_lethality0.66501835
142* MP0010770_preweaning_lethality0.66501835
143MP0001905_abnormal_dopamine_level0.65223848
144* MP0010769_abnormal_survival0.65067334
145MP0003137_abnormal_impulse_conducting0.65029098
146MP0002116_abnormal_craniofacial_bone0.64593043
147MP0001348_abnormal_lacrimal_gland0.64499936
148MP0003385_abnormal_body_wall0.63157072
149MP0003045_fibrosis0.62277469

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.31585381
2Focal seizures (HP:0007359)3.91247868
3Progressive cerebellar ataxia (HP:0002073)3.88406404
4Epileptic encephalopathy (HP:0200134)3.78889338
5Papilledema (HP:0001085)3.63741733
6Myokymia (HP:0002411)3.58610541
7Visual hallucinations (HP:0002367)3.32903996
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24141102
9Febrile seizures (HP:0002373)3.18923860
10Chromsome breakage (HP:0040012)3.11065891
11Hemiparesis (HP:0001269)3.07532465
12Mutism (HP:0002300)3.07199127
13Atonic seizures (HP:0010819)3.06993199
14Broad-based gait (HP:0002136)3.01616561
15Excessive salivation (HP:0003781)3.00258557
16Drooling (HP:0002307)3.00258557
17Agitation (HP:0000713)2.99181341
18Abnormality of binocular vision (HP:0011514)2.96149189
19Diplopia (HP:0000651)2.96149189
20Increased nuchal translucency (HP:0010880)2.95394461
21Genetic anticipation (HP:0003743)2.93182088
22Birth length less than 3rd percentile (HP:0003561)2.84876132
23Cortical dysplasia (HP:0002539)2.84372357
24Hyperventilation (HP:0002883)2.83447861
25Supranuclear gaze palsy (HP:0000605)2.66661422
26Protruding tongue (HP:0010808)2.66479443
27Absence seizures (HP:0002121)2.59258830
28Action tremor (HP:0002345)2.56561659
29Abnormality of the carotid arteries (HP:0005344)2.54097041
30Truncal ataxia (HP:0002078)2.52353141
31Generalized tonic-clonic seizures (HP:0002069)2.50571840
32Amblyopia (HP:0000646)2.49311231
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.48556834
34Progressive inability to walk (HP:0002505)2.47291872
35Impaired smooth pursuit (HP:0007772)2.42461221
36Meckel diverticulum (HP:0002245)2.41784639
37Gaze-evoked nystagmus (HP:0000640)2.40727060
38Ankle clonus (HP:0011448)2.39351282
39Inappropriate behavior (HP:0000719)2.38911523
40Overriding aorta (HP:0002623)2.38611705
41Abnormality of the labia minora (HP:0012880)2.38047027
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.36150024
43Abnormality of chromosome stability (HP:0003220)2.35849426
44Abnormality of the ileum (HP:0001549)2.34668574
45Limb dystonia (HP:0002451)2.34606634
46Poor eye contact (HP:0000817)2.32502563
47Dialeptic seizures (HP:0011146)2.29230435
48Absent/shortened dynein arms (HP:0200106)2.27908704
49Dynein arm defect of respiratory motile cilia (HP:0012255)2.27908704
50Glioma (HP:0009733)2.27561987
51Abnormality of the preputium (HP:0100587)2.26272057
52Absent speech (HP:0001344)2.20677993
53Urinary bladder sphincter dysfunction (HP:0002839)2.20205413
54Renovascular hypertension (HP:0100817)2.20177269
55Open mouth (HP:0000194)2.19343476
56Impaired vibration sensation in the lower limbs (HP:0002166)2.18896723
57Facial hemangioma (HP:0000329)2.18498017
58Astrocytoma (HP:0009592)2.16440975
59Abnormality of the astrocytes (HP:0100707)2.16440975
60Abnormality of the diencephalon (HP:0010662)2.16164067
61Abnormality of ocular smooth pursuit (HP:0000617)2.15902761
62Tented upper lip vermilion (HP:0010804)2.15765199
63Dysdiadochokinesis (HP:0002075)2.13011928
64High anterior hairline (HP:0009890)2.12181956
65Epileptiform EEG discharges (HP:0011182)2.12158557
66Aqueductal stenosis (HP:0002410)2.10513847
67Shoulder girdle muscle weakness (HP:0003547)2.08378600
68EEG with generalized epileptiform discharges (HP:0011198)2.08044855
69Megalencephaly (HP:0001355)2.07598245
70Abnormal lung lobation (HP:0002101)2.07196193
71Amyotrophic lateral sclerosis (HP:0007354)2.06797479
72Stereotypic behavior (HP:0000733)2.05286298
7311 pairs of ribs (HP:0000878)2.04582607
74Lissencephaly (HP:0001339)2.02772573
75Esophageal atresia (HP:0002032)2.02321389
76Abnormality of the lower motor neuron (HP:0002366)2.01834041
77Impaired social interactions (HP:0000735)2.01193980
78Abnormal social behavior (HP:0012433)2.01193980
79Hypsarrhythmia (HP:0002521)2.00112596
80Ectopic kidney (HP:0000086)2.00011923
81Inability to walk (HP:0002540)1.98201754
82Duodenal stenosis (HP:0100867)1.97458387
83Small intestinal stenosis (HP:0012848)1.97458387
84Widely spaced teeth (HP:0000687)1.97234876
85Lower limb amyotrophy (HP:0007210)1.96298264
86Depression (HP:0000716)1.96245367
87Gastroesophageal reflux (HP:0002020)1.96047949
88Urinary urgency (HP:0000012)1.94650002
89Ependymoma (HP:0002888)1.94357968
90Hypoplasia of the brainstem (HP:0002365)1.91902166
91Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91902166
92Dysmetric saccades (HP:0000641)1.91566417
93Hemiplegia (HP:0002301)1.90388797
94Missing ribs (HP:0000921)1.90386427
95Abnormality of salivation (HP:0100755)1.89760508
96Patellar aplasia (HP:0006443)1.88798579
97Pointed chin (HP:0000307)1.88120207
98Macroorchidism (HP:0000053)1.87981739
99Abnormal eating behavior (HP:0100738)1.87004361
100Specific learning disability (HP:0001328)1.85658547
101Polyphagia (HP:0002591)1.85110867
102Absent radius (HP:0003974)1.85034058
103Hyperacusis (HP:0010780)1.84997876
104Ankyloglossia (HP:0010296)1.84842095
105Exotropia (HP:0000577)1.84578871
106Renal duplication (HP:0000075)1.84368732
107Abnormal number of incisors (HP:0011064)1.83619520
108Medulloblastoma (HP:0002885)1.83239837
109Pachygyria (HP:0001302)1.83030559
110Aplasia involving forearm bones (HP:0009822)1.79001199
111Absent forearm bone (HP:0003953)1.79001199
112Obstructive sleep apnea (HP:0002870)1.78544415
113Elfin facies (HP:0004428)1.78296730
114Autism (HP:0000717)1.77973156
115Insomnia (HP:0100785)1.77117928
116Acute lymphatic leukemia (HP:0006721)1.76866914
117Apathy (HP:0000741)1.76533708
118Absent frontal sinuses (HP:0002688)1.76503949
119Volvulus (HP:0002580)1.76382642
120Abnormality of the corticospinal tract (HP:0002492)1.75455206
121Abnormality of the duodenum (HP:0002246)1.74606460
122Heterotopia (HP:0002282)1.74505290
123Obsessive-compulsive behavior (HP:0000722)1.74341806
124Fetal akinesia sequence (HP:0001989)1.73563430
125Intellectual disability, severe (HP:0010864)1.73497224
126Hyperthyroidism (HP:0000836)1.72604159
127Rhabdomyosarcoma (HP:0002859)1.72399139
128Dysmetria (HP:0001310)1.72373733
129Sloping forehead (HP:0000340)1.71570037
130Flat cornea (HP:0007720)1.71168134
131Abnormality of cochlea (HP:0000375)1.70756957
132Oligodactyly (hands) (HP:0001180)1.69888995
133Deep palmar crease (HP:0006191)1.68638164
134Aplasia/Hypoplasia of the patella (HP:0006498)1.68402276
135Anxiety (HP:0000739)1.68168676
136Nephroblastoma (Wilms tumor) (HP:0002667)1.67292860
137Pelvic girdle muscle weakness (HP:0003749)1.66955203
138Proximal placement of thumb (HP:0009623)1.66584117
139Attention deficit hyperactivity disorder (HP:0007018)1.66420246
140Sacral dimple (HP:0000960)1.65943084
141Scanning speech (HP:0002168)1.65606975
142Horseshoe kidney (HP:0000085)1.64645950
143Generalized hypotonia (HP:0001290)1.64633717
144Hepatoblastoma (HP:0002884)1.64599403
145Colon cancer (HP:0003003)1.64494339
146Pendular nystagmus (HP:0012043)1.63683886
147Abnormal respiratory epithelium morphology (HP:0012253)1.63321825
148Abnormal respiratory motile cilium morphology (HP:0005938)1.63321825
149Tapered finger (HP:0001182)1.62863456
150Cafe-au-lait spot (HP:0000957)1.62628127
151Clubbing of toes (HP:0100760)1.62464699
152Morphological abnormality of the inner ear (HP:0011390)1.62437020
153Insidious onset (HP:0003587)1.62327714
154Termporal pattern (HP:0011008)1.62327714
155Cutaneous finger syndactyly (HP:0010554)1.62069836
156Gait imbalance (HP:0002141)1.62039253
157Abnormal ciliary motility (HP:0012262)1.61960108
158Heterochromia iridis (HP:0001100)1.61606628
159Gastrointestinal atresia (HP:0002589)1.61333589
160Triphalangeal thumb (HP:0001199)1.61219445
161Partial agenesis of the corpus callosum (HP:0001338)1.60080894
162Megalocornea (HP:0000485)1.60073348
163Deviation of the thumb (HP:0009603)1.59172926
164Atresia of the external auditory canal (HP:0000413)1.58973482
165Abnormality of chromosome segregation (HP:0002916)1.58910615
166Bilateral microphthalmos (HP:0007633)1.56708320
167Renal hypoplasia (HP:0000089)1.56203739
168Retinal dysplasia (HP:0007973)1.54269948
169Embryonal renal neoplasm (HP:0011794)1.53777772
170Choanal atresia (HP:0000453)1.53684984
171Cutaneous syndactyly (HP:0012725)1.51319756
172Anophthalmia (HP:0000528)1.50678986
173Scrotal hypoplasia (HP:0000046)1.50265858
174Intestinal atresia (HP:0011100)1.49008234
175Uterine leiomyosarcoma (HP:0002891)1.48752744
176Leiomyosarcoma (HP:0100243)1.48752744
177Preaxial hand polydactyly (HP:0001177)1.48698719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.68871171
2NTRK33.61932035
3CDC73.61928673
4NTRK23.09814186
5TSSK62.98024527
6MAPK132.75207726
7MAP3K42.71402621
8WEE12.68299970
9CASK2.64603024
10TTK2.57869098
11EPHA42.55958327
12MINK12.55577163
13PNCK2.44345057
14MAP2K72.35981073
15SIK22.35373516
16MAP3K92.29396786
17TNIK2.13300749
18MKNK12.12250250
19MAP3K101.98911971
20KSR11.97137872
21ZAK1.96864144
22SRPK11.95799655
23PAK61.94913876
24PRPF4B1.84934979
25DAPK21.76467966
26EEF2K1.68284967
27BUB11.65159296
28PLK41.59820442
29PLK21.57786603
30ERBB31.57745064
31PRKD31.51660083
32NEK21.48824704
33CAMK1G1.42957478
34CHEK21.40739694
35ATR1.39280596
36CDK51.38552602
37SIK31.36124714
38EPHB21.31817412
39PBK1.31413051
40CDK121.29004627
41UHMK11.28434880
42PLK31.27759066
43TAF11.25862782
44BRSK21.25235736
45ICK1.24375911
46FES1.23991697
47CAMK1D1.20434178
48MAP2K41.19742933
49PHKG11.19659556
50PHKG21.19659556
51CAMKK11.19454614
52DYRK21.18817154
53NEK11.17910203
54DYRK1A1.13430476
55PLK11.12462891
56DAPK11.08279362
57CSNK1G21.07637571
58CDK31.03567042
59MARK21.02730056
60IRAK21.02484764
61RPS6KB21.01073480
62TYRO31.00516149
63PRKCG0.99338746
64STK390.98993547
65WNK40.97652517
66SIK10.94705998
67MST1R0.93297733
68CHEK10.93287413
69ALK0.89957618
70LATS10.88652355
71VRK10.88065172
72STK110.83952827
73EIF2AK30.82810685
74RPS6KA40.82283691
75GRK50.81470958
76PTK2B0.80304417
77ATM0.79541707
78CSNK1E0.78952481
79SGK20.78362008
80CDK140.78355324
81FGR0.78210057
82CDK10.78132848
83CDK180.77810458
84TAOK20.77685962
85CAMK2A0.75381957
86TAOK10.73571710
87CDK150.72893475
88BCR0.72440117
89AURKB0.71895162
90SGK2230.70215274
91SGK4940.70215274
92MAP3K120.69886284
93CSNK1A1L0.69509881
94SGK10.68284041
95ERBB40.67800606
96CDK70.67654560
97NTRK10.67574326
98MAPK150.67436384
99CDK11A0.67251149
100PAK30.66301942
101RET0.65908947
102CDC42BPA0.65539828
103CDK190.65529672
104AURKA0.64445762
105LATS20.64122941
106EIF2AK20.63516188
107CDK20.63324059
108EIF2AK10.62478476
109CAMK10.60759682
110CSNK1G30.60455637
111RIPK10.60118716
112RIPK40.59880109
113CDK80.59706672
114MET0.58676416
115FGFR20.57768469
116SGK30.56735428
117CLK10.56091178
118PRKCH0.55919267
119BRSK10.55483043
120MTOR0.55071800
121BMPR1B0.54038794
122KDR0.53990562
123PRKCZ0.53585614
124KSR20.53388537
125DYRK30.53139561
126CAMKK20.52602191
127STK380.50996171
128CCNB10.50646095
129PRKCE0.50559945
130WNK30.49981268
131INSRR0.49663690
132SMG10.49475227
133RPS6KA30.49295837
134FYN0.46630139
135RPS6KA20.45914815
136PRKCB0.45635269
137FGFR10.45307976
138GSK3B0.44963772
139MAPK90.44558789
140MELK0.44455656
141MAPK120.43887816
142PKN10.43406747
143MAP3K20.43353271
144MAPK100.43102596
145PRKG10.43085569
146WNK10.43076204
147MAPK80.43038825
148BRAF0.42790486
149MAP3K60.41448440
150NEK60.40142506
151PASK0.40140010
152YES10.37921789
153CAMK2B0.36077135
154RPS6KB10.35984936
155CSNK1G10.35656515
156MKNK20.35313796
157BRD40.35301642
158PRKDC0.34231867

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.25810325
2DNA replication_Homo sapiens_hsa030303.13699018
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.50938065
4Mismatch repair_Homo sapiens_hsa034302.50531473
5Synaptic vesicle cycle_Homo sapiens_hsa047212.43926500
6GABAergic synapse_Homo sapiens_hsa047272.40617250
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37511385
8Cell cycle_Homo sapiens_hsa041102.37134255
9Circadian entrainment_Homo sapiens_hsa047132.35330854
10Glutamatergic synapse_Homo sapiens_hsa047242.33566079
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27995214
12Fanconi anemia pathway_Homo sapiens_hsa034602.23897369
13Morphine addiction_Homo sapiens_hsa050322.18249101
14Homologous recombination_Homo sapiens_hsa034402.14439143
15Non-homologous end-joining_Homo sapiens_hsa034502.10747566
16RNA transport_Homo sapiens_hsa030132.10737909
17Long-term potentiation_Homo sapiens_hsa047202.09031461
18Olfactory transduction_Homo sapiens_hsa047402.06716422
19Dopaminergic synapse_Homo sapiens_hsa047281.97597974
20Amphetamine addiction_Homo sapiens_hsa050311.90230309
21Steroid biosynthesis_Homo sapiens_hsa001001.89622670
22Spliceosome_Homo sapiens_hsa030401.85363934
23Axon guidance_Homo sapiens_hsa043601.80805331
24Insulin secretion_Homo sapiens_hsa049111.79567598
25mRNA surveillance pathway_Homo sapiens_hsa030151.76710499
26Cholinergic synapse_Homo sapiens_hsa047251.75390454
27Long-term depression_Homo sapiens_hsa047301.73133333
28Serotonergic synapse_Homo sapiens_hsa047261.65629734
29Salivary secretion_Homo sapiens_hsa049701.63115198
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59776647
31Taste transduction_Homo sapiens_hsa047421.59257210
32One carbon pool by folate_Homo sapiens_hsa006701.53310537
33Oxytocin signaling pathway_Homo sapiens_hsa049211.51974072
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51765763
35Gastric acid secretion_Homo sapiens_hsa049711.49254989
36Base excision repair_Homo sapiens_hsa034101.48912005
37Cocaine addiction_Homo sapiens_hsa050301.48479879
38RNA polymerase_Homo sapiens_hsa030201.48099052
39Nucleotide excision repair_Homo sapiens_hsa034201.47182421
40Basal transcription factors_Homo sapiens_hsa030221.45410507
41Vitamin B6 metabolism_Homo sapiens_hsa007501.43207453
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38738164
43Selenocompound metabolism_Homo sapiens_hsa004501.33993995
44Renin secretion_Homo sapiens_hsa049241.33297536
45Gap junction_Homo sapiens_hsa045401.28674183
46GnRH signaling pathway_Homo sapiens_hsa049121.25030599
47Glioma_Homo sapiens_hsa052141.24285498
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.22873408
49Type II diabetes mellitus_Homo sapiens_hsa049301.22762771
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.22385559
51Calcium signaling pathway_Homo sapiens_hsa040201.21535523
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20199588
53Phototransduction_Homo sapiens_hsa047441.17911960
54Estrogen signaling pathway_Homo sapiens_hsa049151.16251014
55Lysine degradation_Homo sapiens_hsa003101.14403095
56cAMP signaling pathway_Homo sapiens_hsa040241.13478237
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12870768
58ErbB signaling pathway_Homo sapiens_hsa040121.11164995
59Melanogenesis_Homo sapiens_hsa049161.09701410
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09494132
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08190861
62Dorso-ventral axis formation_Homo sapiens_hsa043201.07244100
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02122442
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00811149
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99481951
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99306062
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.98810739
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.97528822
69RNA degradation_Homo sapiens_hsa030180.94545382
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92817496
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92426273
72MAPK signaling pathway_Homo sapiens_hsa040100.90357859
73Oocyte meiosis_Homo sapiens_hsa041140.90053008
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89256189
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89161477
76Colorectal cancer_Homo sapiens_hsa052100.89099484
77Wnt signaling pathway_Homo sapiens_hsa043100.87571146
78Rap1 signaling pathway_Homo sapiens_hsa040150.85214909
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.84966269
80Endometrial cancer_Homo sapiens_hsa052130.83373800
81Renal cell carcinoma_Homo sapiens_hsa052110.82181305
82Ras signaling pathway_Homo sapiens_hsa040140.82079324
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.81470888
84Choline metabolism in cancer_Homo sapiens_hsa052310.81289545
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79851946
86Biosynthesis of amino acids_Homo sapiens_hsa012300.78842133
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77230566
88Nitrogen metabolism_Homo sapiens_hsa009100.77027278
89Pyrimidine metabolism_Homo sapiens_hsa002400.75570037
90VEGF signaling pathway_Homo sapiens_hsa043700.75282565
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73897902
92Type I diabetes mellitus_Homo sapiens_hsa049400.73242675
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72884197
94Collecting duct acid secretion_Homo sapiens_hsa049660.71182585
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70238341
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69919179
97TGF-beta signaling pathway_Homo sapiens_hsa043500.68251757
98Dilated cardiomyopathy_Homo sapiens_hsa054140.67664157
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67084385
100Circadian rhythm_Homo sapiens_hsa047100.66399267
101Thyroid cancer_Homo sapiens_hsa052160.66040179
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66017931
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65992765
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64752517
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64614204
106Purine metabolism_Homo sapiens_hsa002300.64562962
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.62536735
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.61935881
109Ribosome_Homo sapiens_hsa030100.61443135
110Alcoholism_Homo sapiens_hsa050340.60937734
111Thyroid hormone synthesis_Homo sapiens_hsa049180.60005014
112Chemokine signaling pathway_Homo sapiens_hsa040620.57140109
113Ovarian steroidogenesis_Homo sapiens_hsa049130.56859851
114Hippo signaling pathway_Homo sapiens_hsa043900.56849240
115Melanoma_Homo sapiens_hsa052180.56574678
116Hedgehog signaling pathway_Homo sapiens_hsa043400.56307696
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56088086
118Vibrio cholerae infection_Homo sapiens_hsa051100.55596797
119Non-small cell lung cancer_Homo sapiens_hsa052230.55199866
120mTOR signaling pathway_Homo sapiens_hsa041500.55166262
121Chronic myeloid leukemia_Homo sapiens_hsa052200.55002001
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54671473
123Pancreatic secretion_Homo sapiens_hsa049720.53080094
124Endocytosis_Homo sapiens_hsa041440.52111851
125Glucagon signaling pathway_Homo sapiens_hsa049220.51680069
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51569702
127Basal cell carcinoma_Homo sapiens_hsa052170.51329046
128Protein export_Homo sapiens_hsa030600.51220886
129Pyruvate metabolism_Homo sapiens_hsa006200.50676899
130FoxO signaling pathway_Homo sapiens_hsa040680.50441879
131Inositol phosphate metabolism_Homo sapiens_hsa005620.49633494
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47780664
133MicroRNAs in cancer_Homo sapiens_hsa052060.46998779
134p53 signaling pathway_Homo sapiens_hsa041150.46856697
135Notch signaling pathway_Homo sapiens_hsa043300.46396519
136Prostate cancer_Homo sapiens_hsa052150.45118295
137Adherens junction_Homo sapiens_hsa045200.45057597
138Cardiac muscle contraction_Homo sapiens_hsa042600.44743907
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44270377
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43910234
141Fatty acid biosynthesis_Homo sapiens_hsa000610.43065269
142Tight junction_Homo sapiens_hsa045300.40936211
143Pathways in cancer_Homo sapiens_hsa052000.40240271
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35786051
145Viral carcinogenesis_Homo sapiens_hsa052030.35012934
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33955802

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