LRRC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte development (GO:0003334)6.16775137
2cilium or flagellum-dependent cell motility (GO:0001539)5.82394343
3fusion of sperm to egg plasma membrane (GO:0007342)5.69866765
4sperm motility (GO:0030317)5.38584410
5axonemal dynein complex assembly (GO:0070286)5.34936936
6desmosome organization (GO:0002934)5.30707210
7acrosome assembly (GO:0001675)4.99981779
8bundle of His cell to Purkinje myocyte communication (GO:0086069)4.94017820
9hemidesmosome assembly (GO:0031581)4.74482205
10cell wall macromolecule catabolic process (GO:0016998)4.67946236
11cell wall macromolecule metabolic process (GO:0044036)4.67946236
12acrosome reaction (GO:0007340)4.64177091
13positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)4.52527249
14sperm capacitation (GO:0048240)4.50632277
15sperm-egg recognition (GO:0035036)4.47028092
16multicellular organism reproduction (GO:0032504)4.45389456
17spermatid development (GO:0007286)4.39007078
18epithelial cilium movement (GO:0003351)4.37562528
19cilium movement (GO:0003341)4.21267575
20plasma membrane fusion (GO:0045026)4.15419853
21binding of sperm to zona pellucida (GO:0007339)4.14822262
22cell-cell recognition (GO:0009988)4.00731337
23seminiferous tubule development (GO:0072520)3.92336434
24motile cilium assembly (GO:0044458)3.88601601
25reproduction (GO:0000003)3.83125028
26ectoderm development (GO:0007398)3.64839347
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.57957547
28negative regulation of inclusion body assembly (GO:0090084)3.55436502
29regulation of hexokinase activity (GO:1903299)3.51301623
30regulation of glucokinase activity (GO:0033131)3.51301623
31central nervous system myelination (GO:0022010)3.49637173
32axon ensheathment in central nervous system (GO:0032291)3.49637173
33synaptonemal complex organization (GO:0070193)3.38347792
34regulation of keratinocyte proliferation (GO:0010837)3.34906449
35eye photoreceptor cell differentiation (GO:0001754)3.34862015
36photoreceptor cell differentiation (GO:0046530)3.34862015
37genitalia morphogenesis (GO:0035112)3.30205481
38piRNA metabolic process (GO:0034587)3.25473402
39zinc ion transport (GO:0006829)3.20698887
40regulation of cilium movement (GO:0003352)3.19591793
41regulation of acrosome reaction (GO:0060046)3.15480057
42negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.14602629
43epithelial cell-cell adhesion (GO:0090136)3.13697766
44single fertilization (GO:0007338)3.13473321
45male meiosis (GO:0007140)3.12710054
46apical protein localization (GO:0045176)3.10694831
47myelin maintenance (GO:0043217)3.10194056
48synaptonemal complex assembly (GO:0007130)3.09515841
49auditory receptor cell differentiation (GO:0042491)3.06271892
50negative regulation of organelle assembly (GO:1902116)3.05825724
51regulation of cytokine production involved in inflammatory response (GO:1900015)3.02413061
52regulation of protein glycosylation (GO:0060049)2.98785578
53prostate gland growth (GO:0060736)2.95172630
54positive regulation of glycoprotein biosynthetic process (GO:0010560)2.94780798
55hypotonic response (GO:0006971)2.92976387
56interferon-gamma secretion (GO:0072643)2.90461288
57fertilization (GO:0009566)2.90213423
58glomerular visceral epithelial cell development (GO:0072015)2.90068389
59lactate metabolic process (GO:0006089)2.89446675
60negative regulation of potassium ion transmembrane transport (GO:1901380)2.87861016
61regulation of chemokine secretion (GO:0090196)2.83749667
62glomerular epithelial cell development (GO:0072310)2.83498605
63negative regulation of dendrite development (GO:2000171)2.82090217
64asymmetric protein localization (GO:0008105)2.79058113
65dorsal/ventral axis specification (GO:0009950)2.78293464
66spermatogenesis (GO:0007283)2.77990594
67ventricular system development (GO:0021591)2.77093029
68Sertoli cell development (GO:0060009)2.76804494
69negative regulation of skeletal muscle tissue development (GO:0048642)2.76714962
70male gamete generation (GO:0048232)2.76402644
71ventricular cardiac muscle cell action potential (GO:0086005)2.74932028
72embryonic retina morphogenesis in camera-type eye (GO:0060059)2.74287127
73germ cell development (GO:0007281)2.74259521
74tight junction assembly (GO:0070830)2.73168135
75male meiosis I (GO:0007141)2.70293300
76regulation of cardioblast differentiation (GO:0051890)2.70023473
77type B pancreatic cell development (GO:0003323)2.69735136
78negative regulation of stem cell proliferation (GO:2000647)2.68513415
79protein targeting to Golgi (GO:0000042)2.68036038
80retrograde transport, vesicle recycling within Golgi (GO:0000301)2.67983307
81cellular process involved in reproduction in multicellular organism (GO:0022412)2.67015646
82columnar/cuboidal epithelial cell development (GO:0002066)2.66326026
83negative regulation of keratinocyte proliferation (GO:0010839)2.64601132
84oocyte development (GO:0048599)2.63536779
85histone H3-K9 demethylation (GO:0033169)2.60636091
86gamete generation (GO:0007276)2.60171485
87righting reflex (GO:0060013)2.59416253
88transepithelial transport (GO:0070633)2.58734116
89positive regulation of glycolytic process (GO:0045821)2.57776151
90positive regulation of glycoprotein metabolic process (GO:1903020)2.57730133
91negative regulation of astrocyte differentiation (GO:0048712)2.55525292
92kidney morphogenesis (GO:0060993)2.53114258
93endocrine pancreas development (GO:0031018)2.52384649
94protein localization to endosome (GO:0036010)2.52043845
95hindbrain development (GO:0030902)2.51977931
96regulation of steroid hormone biosynthetic process (GO:0090030)2.51627425
97cytoskeletal anchoring at plasma membrane (GO:0007016)2.50916158
98positive regulation of protein autophosphorylation (GO:0031954)2.49662709
99polarized epithelial cell differentiation (GO:0030859)2.49300457
100protein K11-linked deubiquitination (GO:0035871)2.46878787
101glandular epithelial cell differentiation (GO:0002067)2.46742458
102zinc ion transmembrane transport (GO:0071577)2.45929926
103intestinal epithelial cell development (GO:0060576)2.45719781
104negative regulation of cell fate commitment (GO:0010454)2.45653772
105zinc ion homeostasis (GO:0055069)2.45513746
106negative regulation of neurological system process (GO:0031645)2.45262106
107regulation of water loss via skin (GO:0033561)2.43307944
108cellular glucuronidation (GO:0052695)2.42992822
109keratinization (GO:0031424)2.42195544
110cardiac right ventricle morphogenesis (GO:0003215)2.41996399
111dopamine transport (GO:0015872)2.41740291
112presynaptic membrane assembly (GO:0097105)2.41674134
113positive regulation of megakaryocyte differentiation (GO:0045654)2.40699613
114intestinal absorption (GO:0050892)2.40327286
115renal system development (GO:0072001)2.39135213
116calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.38681308
117establishment of protein localization to Golgi (GO:0072600)2.38446175
118organic cation transport (GO:0015695)2.38083195
119establishment of skin barrier (GO:0061436)2.37812938
120lung secretory cell differentiation (GO:0061140)2.37207346
121uronic acid metabolic process (GO:0006063)2.36925582
122glucuronate metabolic process (GO:0019585)2.36925582
123cell communication involved in cardiac conduction (GO:0086065)2.36464452
124purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.36417563
1253-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.36417563
126phenylpropanoid metabolic process (GO:0009698)2.36360945
127cell-cell junction assembly (GO:0007043)2.35898692
128regulation of heart rate by cardiac conduction (GO:0086091)2.35064733
129regulation of male gonad development (GO:2000018)2.35015847
130left/right pattern formation (GO:0060972)2.34661185
131sphingosine metabolic process (GO:0006670)2.34257391
132regulation of guanylate cyclase activity (GO:0031282)2.34254567
133polyol catabolic process (GO:0046174)2.34226437
134L-fucose catabolic process (GO:0042355)2.34061502
135fucose catabolic process (GO:0019317)2.34061502
136L-fucose metabolic process (GO:0042354)2.34061502
137inositol phosphate catabolic process (GO:0071545)2.34020197
138glycerophospholipid catabolic process (GO:0046475)2.33434379
139dentate gyrus development (GO:0021542)2.33105740
140vitamin transmembrane transport (GO:0035461)2.32627781
141regulation of hippo signaling (GO:0035330)2.32550369
142cornea development in camera-type eye (GO:0061303)2.31755662
143membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.31531793
144positive regulation of hormone biosynthetic process (GO:0046886)2.30241754
145glandular epithelial cell development (GO:0002068)2.30001960
146relaxation of cardiac muscle (GO:0055119)2.28199839
147keratinocyte proliferation (GO:0043616)2.27028531
148positive regulation of mitotic sister chromatid separation (GO:1901970)2.26690325
149positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.26690325
150positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.26690325
151startle response (GO:0001964)2.26563965
152ER overload response (GO:0006983)2.26512231
153diol metabolic process (GO:0034311)2.26198811
154sphingoid metabolic process (GO:0046519)2.26182370
155regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.25552464
156negative regulation of cell fate specification (GO:0009996)2.25314756
157neurotransmitter-gated ion channel clustering (GO:0072578)2.25237217
158negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.25154233
159negative regulation of translation, ncRNA-mediated (GO:0040033)2.25154233
160regulation of translation, ncRNA-mediated (GO:0045974)2.25154233
161regulation of glucocorticoid metabolic process (GO:0031943)2.25136655
162limb bud formation (GO:0060174)2.24874522
163sulfate transmembrane transport (GO:1902358)2.22935795
164lipid translocation (GO:0034204)2.22795814
165phospholipid translocation (GO:0045332)2.22795814
166negative regulation of glycogen biosynthetic process (GO:0045719)2.22063355
167microtubule severing (GO:0051013)2.22030152
168photoreceptor cell maintenance (GO:0045494)2.21443495
169phospholipid catabolic process (GO:0009395)2.21079038
170negative regulation of hormone biosynthetic process (GO:0032353)2.19353213
171high-density lipoprotein particle remodeling (GO:0034375)2.19312584
172gap junction assembly (GO:0016264)2.19256744
173regulation of type B pancreatic cell apoptotic process (GO:2000674)2.19085189
174detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.17943058
175cellular ketone body metabolic process (GO:0046950)2.16235212
176positive regulation of growth hormone secretion (GO:0060124)2.15794494
177cellular zinc ion homeostasis (GO:0006882)2.14905908
178protein K6-linked ubiquitination (GO:0085020)2.12699036
179prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.12528867
180mitotic sister chromatid cohesion (GO:0007064)2.11998071
181positive regulation of guanylate cyclase activity (GO:0031284)2.09785563
182nephron tubule formation (GO:0072079)2.09615423
183Golgi to endosome transport (GO:0006895)2.09418422
184regulation of growth hormone secretion (GO:0060123)2.09260000
185flavonoid metabolic process (GO:0009812)2.08160408
186ketone body metabolic process (GO:1902224)2.06385258
187reflex (GO:0060004)2.05982691
188negative regulation of dendrite morphogenesis (GO:0050774)2.05748427
189thyroid hormone metabolic process (GO:0042403)2.05652833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.92211822
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.35813359
3ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.01153814
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.96375245
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.87985764
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60949301
7GBX2_23144817_ChIP-Seq_PC3_Human2.52732811
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39326269
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.38341812
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37510290
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31726699
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27918662
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26024528
14* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.16884988
15SOX9_24532713_ChIP-Seq_HFSC_Mouse2.08192430
16SOX2_27498859_Chip-Seq_STOMACH_Mouse2.06324190
17PIAS1_25552417_ChIP-Seq_VCAP_Human2.02638768
18TAF15_26573619_Chip-Seq_HEK293_Human1.99595937
19* FOXO3_23340844_ChIP-Seq_DLD1_Human1.91924693
20FUS_26573619_Chip-Seq_HEK293_Human1.86978536
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86597094
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.83208328
23P300_19829295_ChIP-Seq_ESCs_Human1.82626462
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76276156
25EWS_26573619_Chip-Seq_HEK293_Human1.74809433
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71689111
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70097000
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67829738
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.64407374
30* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63736002
31TCF4_18268006_ChIP-ChIP_LS174T_Human1.63412646
32TBX20_22080862_ChIP-Seq_HEART_Mouse1.62434758
33TBX20_22328084_ChIP-Seq_HEART_Mouse1.62434758
34BCAT_22108803_ChIP-Seq_LS180_Human1.61781985
35AR_25329375_ChIP-Seq_VCAP_Human1.60293173
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.59759856
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58686927
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55457464
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.53961903
40GATA6_25053715_ChIP-Seq_YYC3_Human1.52829297
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.51826317
42* TCF4_22108803_ChIP-Seq_LS180_Human1.51704879
43ER_23166858_ChIP-Seq_MCF-7_Human1.50371570
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49865193
45IGF1R_20145208_ChIP-Seq_DFB_Human1.48056531
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44059409
47* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42462068
48* GATA4_25053715_ChIP-Seq_YYC3_Human1.40394001
49ISL1_27105846_Chip-Seq_CPCs_Mouse1.39118358
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37346680
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34843126
52* TCF4_23295773_ChIP-Seq_U87_Human1.34708045
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34684657
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34545580
55* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34370964
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.33903557
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30739583
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30661809
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30076533
60* STAT3_23295773_ChIP-Seq_U87_Human1.29345060
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.29189952
62* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27879393
63KLF5_25053715_ChIP-Seq_YYC3_Human1.27726048
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27641103
65CBP_20019798_ChIP-Seq_JUKART_Human1.27641103
66SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27124052
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27124052
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25626640
69GATA1_22025678_ChIP-Seq_K562_Human1.25248051
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23997711
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.22852193
72FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21789187
73ZNF274_21170338_ChIP-Seq_K562_Hela1.21753229
74* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21493126
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.21103758
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20537505
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20505375
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20076320
79* RUNX2_22187159_ChIP-Seq_PCA_Human1.19203694
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18128491
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.17724399
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.17328056
83AHR_22903824_ChIP-Seq_MCF-7_Human1.15158841
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15080128
85* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13083166
86TP63_23658742_ChIP-Seq_EP156T_Human1.12850770
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.12455484
88* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11907442
89CJUN_26792858_Chip-Seq_BT549_Human1.11816917
90TP53_18474530_ChIP-ChIP_U2OS_Human1.10873239
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10359411
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09476859
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.09362061
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08586565
95EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08034536
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05882883
97* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05330048
98P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05211046
99* SOX2_20726797_ChIP-Seq_SW620_Human1.05045125
100* FOXA2_19822575_ChIP-Seq_HepG2_Human1.04815582
101* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04015655
102CDX2_22108803_ChIP-Seq_LS180_Human1.02819310
103PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02775172
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02023075
105ESR1_21235772_ChIP-Seq_MCF-7_Human1.02015031
106VDR_22108803_ChIP-Seq_LS180_Human1.02003237
107TBL1_22424771_ChIP-Seq_293T_Human1.01240630
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.01133666
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00974240
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99791487
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99753428
112TP63_22573176_ChIP-Seq_HFKS_Human0.99707485
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99641765
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99568020
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99015550
116FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98730834
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98421050
118UBF1/2_26484160_Chip-Seq_HMECs_Human0.97903741
119SMAD4_21741376_ChIP-Seq_EPCs_Human0.96093868
120EZH2_27294783_Chip-Seq_NPCs_Mouse0.95940386
121* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95904462
122P53_22387025_ChIP-Seq_ESCs_Mouse0.94907658
123CMYC_18555785_Chip-Seq_ESCs_Mouse0.93662278
124BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93454494
125CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92902275
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92380415
127AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91613870
128* GATA3_24758297_ChIP-Seq_MCF-7_Human0.90851531
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90373127
130TAL1_26923725_Chip-Seq_HPCs_Mouse0.86609573
131CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86597594
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.86142279
133* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85732143
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85462235
135GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85351645
136EZH2_22144423_ChIP-Seq_EOC_Human0.84773864
137PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84502529
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84359845
139* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82663402
140AR_21909140_ChIP-Seq_LNCAP_Human0.82517638
141JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82384351
142WDR5_24793694_ChIP-Seq_LNCAP_Human0.82147110
143* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82044163
144* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80973522
145NFYB_21822215_ChIP-Seq_K562_Human0.80911882
146FOXA1_25552417_ChIP-Seq_VCAP_Human0.79930019
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.78187867
148TP53_16413492_ChIP-PET_HCT116_Human0.78177439
149HIF1A_21447827_ChIP-Seq_MCF-7_Human0.77658411
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.77587937
151* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77559296
152NFYA_21822215_ChIP-Seq_K562_Human0.77473792
153AR_21572438_ChIP-Seq_LNCaP_Human0.77172384
154SMAD3_21741376_ChIP-Seq_ESCs_Human0.77024207
155CBX2_27304074_Chip-Seq_ESCs_Mouse0.76586181
156TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76315964
157GF1_26923725_Chip-Seq_HPCs_Mouse0.76186663
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75613758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.98317425
2MP0003950_abnormal_plasma_membrane4.67142141
3MP0010234_abnormal_vibrissa_follicle3.48324514
4MP0010678_abnormal_skin_adnexa2.60614210
5MP0000462_abnormal_digestive_system2.59102866
6MP0006072_abnormal_retinal_apoptosis2.55120791
7MP0002796_impaired_skin_barrier2.54771621
8MP0000383_abnormal_hair_follicle2.34122862
9MP0004264_abnormal_extraembryonic_tissu2.26191625
10MP0003195_calcinosis2.18657712
11MP0004084_abnormal_cardiac_muscle2.15401168
12MP0003878_abnormal_ear_physiology2.13577451
13MP0005377_hearing/vestibular/ear_phenot2.13577451
14MP0000537_abnormal_urethra_morphology2.03697769
15MP0000762_abnormal_tongue_morphology1.98571084
16MP0005623_abnormal_meninges_morphology1.93081123
17MP0003718_maternal_effect1.88717560
18MP0003941_abnormal_skin_development1.88709779
19MP0004043_abnormal_pH_regulation1.88613628
20MP0000427_abnormal_hair_cycle1.88245374
21MP0005501_abnormal_skin_physiology1.87613181
22MP0003698_abnormal_male_reproductive1.86893741
23MP0001666_abnormal_nutrient_absorption1.85815084
24MP0003300_gastrointestinal_ulcer1.82770971
25MP0005646_abnormal_pituitary_gland1.81671700
26MP0002938_white_spotting1.81310386
27MP0001929_abnormal_gametogenesis1.78005956
28MP0002234_abnormal_pharynx_morphology1.72833349
29MP0000566_synostosis1.67403729
30MP0002909_abnormal_adrenal_gland1.60897382
31MP0004185_abnormal_adipocyte_glucose1.59126884
32MP0003123_paternal_imprinting1.57870432
33MP0003122_maternal_imprinting1.56685528
34MP0004147_increased_porphyrin_level1.54765015
35MP0000467_abnormal_esophagus_morphology1.48454423
36MP0005275_abnormal_skin_tensile1.47299519
37MP0002060_abnormal_skin_morphology1.46438545
38MP0002098_abnormal_vibrissa_morphology1.46432409
39MP0003566_abnormal_cell_adhesion1.46313108
40MP0003283_abnormal_digestive_organ1.44802023
41MP0002877_abnormal_melanocyte_morpholog1.44194366
42MP0002876_abnormal_thyroid_physiology1.44184796
43MP0006054_spinal_hemorrhage1.42136765
44MP0002653_abnormal_ependyma_morphology1.41726523
45MP0004036_abnormal_muscle_relaxation1.40592005
46MP0002009_preneoplasia1.40060258
47MP0008004_abnormal_stomach_pH1.39259789
48MP0005085_abnormal_gallbladder_physiolo1.38408226
49MP0001765_abnormal_ion_homeostasis1.37740509
50MP0000003_abnormal_adipose_tissue1.37399823
51MP0001216_abnormal_epidermal_layer1.35375997
52MP0002736_abnormal_nociception_after1.33865969
53MP0002282_abnormal_trachea_morphology1.33707996
54MP0004019_abnormal_vitamin_homeostasis1.33674908
55MP0005379_endocrine/exocrine_gland_phen1.33481340
56MP0002160_abnormal_reproductive_system1.32841328
57MP0003868_abnormal_feces_composition1.30106782
58MP0001849_ear_inflammation1.27973210
59MP0005360_urolithiasis1.27339779
60MP0001346_abnormal_lacrimal_gland1.26493835
61MP0003453_abnormal_keratinocyte_physiol1.25082942
62MP0004272_abnormal_basement_membrane1.24963307
63MP0004134_abnormal_chest_morphology1.23396748
64MP0009250_abnormal_appendicular_skeleto1.22997319
65MP0005253_abnormal_eye_physiology1.22500583
66MP0005187_abnormal_penis_morphology1.20332471
67MP0000538_abnormal_urinary_bladder1.19874331
68MP0000579_abnormal_nail_morphology1.18543789
69MP0002210_abnormal_sex_determination1.17494163
70MP0009384_cardiac_valve_regurgitation1.16147312
71MP0010771_integument_phenotype1.15111250
72MP0003385_abnormal_body_wall1.14820875
73MP0000534_abnormal_ureter_morphology1.14738302
74MP0005367_renal/urinary_system_phenotyp1.14413026
75MP0000516_abnormal_urinary_system1.14413026
76MP0004233_abnormal_muscle_weight1.12208381
77MP0000377_abnormal_hair_follicle1.11426646
78MP0005408_hypopigmentation1.07778058
79MP0005395_other_phenotype1.07567036
80MP0000613_abnormal_salivary_gland1.07406666
81MP0008877_abnormal_DNA_methylation1.06773566
82MP0005220_abnormal_exocrine_pancreas1.06516207
83MP0009780_abnormal_chondrocyte_physiolo1.05912779
84MP0001145_abnormal_male_reproductive1.05118542
85MP0004885_abnormal_endolymph1.04615325
86MP0005375_adipose_tissue_phenotype1.03438807
87MP0001270_distended_abdomen1.03321861
88MP0000432_abnormal_head_morphology1.02488348
89MP0000631_abnormal_neuroendocrine_gland1.01984438
90MP0005248_abnormal_Harderian_gland1.01848396
91MP0002896_abnormal_bone_mineralization1.01723986
92MP0000678_abnormal_parathyroid_gland1.01595853
93MP0000470_abnormal_stomach_morphology1.01058744
94MP0005551_abnormal_eye_electrophysiolog1.00589689
95MP0000647_abnormal_sebaceous_gland0.99099665
96MP0003937_abnormal_limbs/digits/tail_de0.99072172
97MP0010352_gastrointestinal_tract_polyps0.97937102
98MP0010329_abnormal_lipoprotein_level0.97646298
99MP0005365_abnormal_bile_salt0.96473272
100MP0001944_abnormal_pancreas_morphology0.96360255
101MP0004782_abnormal_surfactant_physiolog0.95936695
102MP0005391_vision/eye_phenotype0.95640345
103MP0000653_abnormal_sex_gland0.94578996
104MP0005332_abnormal_amino_acid0.94504141
105MP0003121_genomic_imprinting0.94013577
106MP0002233_abnormal_nose_morphology0.93801859
107MP0003755_abnormal_palate_morphology0.93596209
108MP0003252_abnormal_bile_duct0.93027633
109MP0003935_abnormal_craniofacial_develop0.92840305
110MP0008875_abnormal_xenobiotic_pharmacok0.91658929
111MP0005636_abnormal_mineral_homeostasis0.91590409
112MP0004270_analgesia0.91411018
113MP0008775_abnormal_heart_ventricle0.90268927
114MP0001293_anophthalmia0.90225033
115MP0010630_abnormal_cardiac_muscle0.89789165
116MP0003136_yellow_coat_color0.88625403
117MP0002163_abnormal_gland_morphology0.87769659
118MP0005381_digestive/alimentary_phenotyp0.87388765
119MP0001784_abnormal_fluid_regulation0.86950126
120MP0001984_abnormal_olfaction0.86756273
121MP0003787_abnormal_imprinting0.85884659
122MP0010030_abnormal_orbit_morphology0.85462782
123MP0005666_abnormal_adipose_tissue0.85265864
124MP0002751_abnormal_autonomic_nervous0.84924341
125MP0003943_abnormal_hepatobiliary_system0.84818682
126MP0010307_abnormal_tumor_latency0.84393428
127MP0002161_abnormal_fertility/fecundity0.83945491
128MP0001485_abnormal_pinna_reflex0.83709403
129MP0008961_abnormal_basal_metabolism0.83367088
130MP0003119_abnormal_digestive_system0.82940545
131MP0004215_abnormal_myocardial_fiber0.82590808
132MP0002090_abnormal_vision0.82068219
133MP0000372_irregular_coat_pigmentation0.82052259
134MP0001756_abnormal_urination0.81973798
135MP0006138_congestive_heart_failure0.80621918
136MP0001873_stomach_inflammation0.80490141
137MP0002092_abnormal_eye_morphology0.80071172
138MP0003183_abnormal_peptide_metabolism0.79869934
139MP0004087_abnormal_muscle_fiber0.77968429
140MP0001324_abnormal_eye_pigmentation0.77937324
141MP0001664_abnormal_digestion0.77928594
142MP0004484_altered_response_of0.77780414
143MP0008872_abnormal_physiological_respon0.77133528
144MP0005076_abnormal_cell_differentiation0.76717468
145MP0000477_abnormal_intestine_morphology0.75487011
146MP0002116_abnormal_craniofacial_bone0.75413443
147MP0005645_abnormal_hypothalamus_physiol0.75035114
148MP0003936_abnormal_reproductive_system0.74809481
149MP0001968_abnormal_touch/_nociception0.74571328
150MP0001188_hyperpigmentation0.74537930
151MP0002102_abnormal_ear_morphology0.73991837
152MP0002972_abnormal_cardiac_muscle0.73785192
153MP0003705_abnormal_hypodermis_morpholog0.73525148
154MP0000013_abnormal_adipose_tissue0.73340571
155MP0006292_abnormal_olfactory_placode0.73138329
156MP0005075_abnormal_melanosome_morpholog0.71337970
157MP0000778_abnormal_nervous_system0.70926108
158MP0005389_reproductive_system_phenotype0.70019641
159MP0009840_abnormal_foam_cell0.68495245
160MP0002139_abnormal_hepatobiliary_system0.67924222
161MP0004381_abnormal_hair_follicle0.67133955
162MP0002254_reproductive_system_inflammat0.65541849

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.11352740
2Absent/shortened dynein arms (HP:0200106)5.64442554
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.64442554
4Right ventricular cardiomyopathy (HP:0011663)4.70618457
5Abnormal respiratory motile cilium physiology (HP:0012261)4.54582589
6Abnormal respiratory epithelium morphology (HP:0012253)4.05576064
7Abnormal respiratory motile cilium morphology (HP:0005938)4.05576064
8Abnormal ciliary motility (HP:0012262)3.84314516
9Hypoglycemic seizures (HP:0002173)3.77996775
10Hypoglycemic coma (HP:0001325)3.50233942
11Chronic bronchitis (HP:0004469)3.47580043
12Hyperinsulinemic hypoglycemia (HP:0000825)3.36659710
13Hypoplastic ischia (HP:0003175)3.35831037
14Rhinitis (HP:0012384)3.35766334
15Abnormality of the astrocytes (HP:0100707)3.24481076
16Astrocytoma (HP:0009592)3.24481076
17Epiphyseal dysplasia (HP:0002656)3.12837017
18Milia (HP:0001056)3.07155873
19Flat acetabular roof (HP:0003180)3.03737745
20Pili torti (HP:0003777)2.93461685
21Abnormality of the ischium (HP:0003174)2.87998837
22Vitreoretinal degeneration (HP:0000655)2.80192388
23Infertility (HP:0000789)2.78503244
24Ependymoma (HP:0002888)2.73785569
25Ventricular tachycardia (HP:0004756)2.72456990
26Onycholysis (HP:0001806)2.70429224
27Rectal prolapse (HP:0002035)2.69844167
28Fragile nails (HP:0001808)2.69173680
29Glioma (HP:0009733)2.64208659
30Symptomatic seizures (HP:0011145)2.62465018
31Hyporeflexia of lower limbs (HP:0002600)2.61614432
32Hypothermia (HP:0002045)2.61410138
33Delayed epiphyseal ossification (HP:0002663)2.57411533
34Abnormality of endocrine pancreas physiology (HP:0012093)2.56145017
35Abnormality of the pancreatic islet cells (HP:0006476)2.56145017
36Abnormality of the nasal septum (HP:0000419)2.54613204
37Woolly hair (HP:0002224)2.54022938
38Male infertility (HP:0003251)2.51219197
39Hamartoma of the eye (HP:0010568)2.50589103
40Hypoplastic labia majora (HP:0000059)2.50397689
41Hyperglycemia (HP:0003074)2.50216962
42Nasal polyposis (HP:0100582)2.49989596
43Abnormal biliary tract morphology (HP:0012440)2.44921265
44Abnormal vertebral ossification (HP:0100569)2.40848430
45Concave nail (HP:0001598)2.34839556
46Bronchiectasis (HP:0002110)2.34609640
47Flattened epiphyses (HP:0003071)2.34571332
48Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.33770454
49Abnormal pancreas size (HP:0012094)2.33276004
50Hypobetalipoproteinemia (HP:0003563)2.30768730
51Biliary tract neoplasm (HP:0100574)2.29968608
52Ketoacidosis (HP:0001993)2.29715948
53Neonatal short-limb short stature (HP:0008921)2.28522365
54Rhabdomyosarcoma (HP:0002859)2.23123905
55Abnormal tarsal ossification (HP:0008369)2.21533765
56Abnormality of the labia majora (HP:0012881)2.21508974
57Aqueductal stenosis (HP:0002410)2.19321599
58Septate vagina (HP:0001153)2.16045210
59Bronchitis (HP:0012387)2.13498570
60Curly hair (HP:0002212)2.13355798
61Breast carcinoma (HP:0003002)2.13143106
62Absent eyebrow (HP:0002223)2.11378344
63Enlarged penis (HP:0000040)2.09536462
64Irregular epiphyses (HP:0010582)2.08830505
65Abnormality of the metopic suture (HP:0005556)2.08733246
66Spontaneous abortion (HP:0005268)2.06719113
67Bifid tongue (HP:0010297)2.06577899
68Sudden death (HP:0001699)2.05331659
69EEG with generalized epileptiform discharges (HP:0011198)2.04703502
70Plantar hyperkeratosis (HP:0007556)2.04242900
71Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04221880
72Pancreatic islet-cell hyperplasia (HP:0004510)2.03309199
73Abnormal cartilage morphology (HP:0002763)2.03260760
74True hermaphroditism (HP:0010459)2.02543369
75Abnormality of vitamin B metabolism (HP:0004340)2.02418924
76Hypsarrhythmia (HP:0002521)2.00518653
77Hyperventilation (HP:0002883)2.00364228
78Abnormality of the nasal mucosa (HP:0000433)2.00320840
79Genu varum (HP:0002970)2.00147759
80Midline defect of the nose (HP:0004122)1.99783640
81Palmar hyperkeratosis (HP:0010765)1.98467052
82Abnormal foot bone ossification (HP:0010675)1.97927117
83Chronic hepatic failure (HP:0100626)1.96548032
84Vascular calcification (HP:0004934)1.96519293
85Abnormality of the renal cortex (HP:0011035)1.94381408
86Neoplasm of the adrenal cortex (HP:0100641)1.92871102
87Abnormality of chloride homeostasis (HP:0011422)1.92505376
88Ventricular fibrillation (HP:0001663)1.92166058
89Hypoplasia of dental enamel (HP:0006297)1.92020597
90Pancreatic fibrosis (HP:0100732)1.91798191
91Cupped ribs (HP:0000887)1.91513151
92Epileptiform EEG discharges (HP:0011182)1.91505641
93Pancreatic cysts (HP:0001737)1.89851009
94Stage 5 chronic kidney disease (HP:0003774)1.89829007
95Atrophic scars (HP:0001075)1.89392058
96Metabolic alkalosis (HP:0200114)1.88991768
97Palmoplantar hyperkeratosis (HP:0000972)1.88715027
98Hypomagnesemia (HP:0002917)1.87338385
99Muscle fiber splitting (HP:0003555)1.86958967
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.86263521
101Hypoplasia of the fovea (HP:0007750)1.86263521
102Abnormality of renin-angiotensin system (HP:0000847)1.86255498
103Fat malabsorption (HP:0002630)1.86076771
104Abnormality of the vitamin B12 metabolism (HP:0004341)1.85367122
105Buphthalmos (HP:0000557)1.85061718
106Prominent metopic ridge (HP:0005487)1.83362345
107Cone-rod dystrophy (HP:0000548)1.83120604
108Asymmetry of the thorax (HP:0001555)1.82006835
109Ileus (HP:0002595)1.81795204
110Late onset (HP:0003584)1.81449847
111Short hallux (HP:0010109)1.81286403
112Enlarged epiphyses (HP:0010580)1.81255157
113Macroorchidism (HP:0000053)1.80381743
114Abnormality of the dental pulp (HP:0006479)1.80200192
115Syncope (HP:0001279)1.79549866
116Pigmentary retinal degeneration (HP:0001146)1.78849956
117Chorioretinal atrophy (HP:0000533)1.78370503
118Vertebral clefting (HP:0008428)1.77301123
119Tracheal stenosis (HP:0002777)1.76611789
120Type II lissencephaly (HP:0007260)1.75892672
121Papillary thyroid carcinoma (HP:0002895)1.75566806
122Molar tooth sign on MRI (HP:0002419)1.75411885
123Abnormality of midbrain morphology (HP:0002418)1.75411885
124Decreased circulating renin level (HP:0003351)1.75312362
125Pterygium (HP:0001059)1.74714484
126Abnormality of the middle phalanges of the toes (HP:0010183)1.73709392
127Metaphyseal cupping (HP:0003021)1.73520260
128Lip pit (HP:0100267)1.73377081
129Abnormality of vitamin metabolism (HP:0100508)1.72849843
130Congenital malformation of the right heart (HP:0011723)1.72645971
131Double outlet right ventricle (HP:0001719)1.72645971
132Abnormality of the proximal phalanges of the hand (HP:0009834)1.72323345
133Limited elbow extension (HP:0001377)1.70180792
134Abnormality of molar morphology (HP:0011070)1.70149682
135Abnormality of the fovea (HP:0000493)1.68726305
136Aplasia/Hypoplasia of the hallux (HP:0008362)1.68616654
137Malnutrition (HP:0004395)1.68570342
138Barrel-shaped chest (HP:0001552)1.68431763
139Bony spicule pigmentary retinopathy (HP:0007737)1.67309635
140Abnormality of the phalanges of the 2nd finger (HP:0009541)1.67225237
141Prolonged QT interval (HP:0001657)1.66932491
142Hyperglycinuria (HP:0003108)1.66725576
143Fair hair (HP:0002286)1.66622763
144Intrahepatic cholestasis (HP:0001406)1.66055060
145Renal hypoplasia (HP:0000089)1.65893195
146Genital tract atresia (HP:0001827)1.64927895
147Popliteal pterygium (HP:0009756)1.64205687
148Hypoplasia of the iris (HP:0007676)1.63300892
149Abdominal distention (HP:0003270)1.63256595
150Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62996122
151Furrowed tongue (HP:0000221)1.62898120
152Decreased central vision (HP:0007663)1.62511080
153Abnormality of magnesium homeostasis (HP:0004921)1.62413022
154Hip contracture (HP:0003273)1.62274447
155Tubular atrophy (HP:0000092)1.61561194
156Abnormality of the dental root (HP:0006486)1.61279275
157Taurodontia (HP:0000679)1.61279275
158Abnormality of permanent molar morphology (HP:0011071)1.61279275
159Polydipsia (HP:0001959)1.60114885
160Abnormal drinking behavior (HP:0030082)1.60114885
161Ketosis (HP:0001946)1.60043529
162Proximal tubulopathy (HP:0000114)1.59415513
163Neoplasm of striated muscle (HP:0009728)1.58899278
164Scrotal hypoplasia (HP:0000046)1.57922319
165Cardiovascular calcification (HP:0011915)1.57644420
166Abnormality of the renal medulla (HP:0100957)1.57367214
167Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.57297781
168Vaginal atresia (HP:0000148)1.57240852
169Abnormality of renal excretion (HP:0011036)1.57076114
170Abnormal hair laboratory examination (HP:0003328)1.56881429
171Hyperactive renin-angiotensin system (HP:0000841)1.56015759
172Congenital sensorineural hearing impairment (HP:0008527)1.55880250
173Abnormality of the 2nd finger (HP:0004100)1.55536482
174Corneal erosion (HP:0200020)1.55136310
175Abnormal hand bone ossification (HP:0010660)1.54354393
176Dyschromatopsia (HP:0007641)1.54296291
177Chronic sinusitis (HP:0011109)1.54274370
178Short femoral neck (HP:0100864)1.54246748
179Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.53826002
180Congenital glaucoma (HP:0001087)1.53668709
181Coronal craniosynostosis (HP:0004440)1.52986541
182Abnormality of the epiphyses of the hand (HP:0005924)1.52717673
183Fibular hypoplasia (HP:0003038)1.52512754
184Limited hip movement (HP:0008800)1.51573364
185Short ribs (HP:0000773)1.51195488
186Nephronophthisis (HP:0000090)1.51120834
187Congenital stationary night blindness (HP:0007642)1.51045279
188Aplasia/hypoplasia of the femur (HP:0005613)1.50935452
189Abnormality of molar (HP:0011077)1.48814690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.59147309
2MST1R3.48482034
3PDK43.47598774
4PDK33.47598774
5WNK43.17227916
6MST43.14883791
7PIK3CA2.67884295
8PRKD32.52448419
9DMPK2.49631352
10TESK12.47509898
11PDK22.34251453
12EIF2AK32.31685762
13MET2.30108935
14LMTK22.22051258
15ACVR1B2.15505069
16MAP3K22.15110073
17CASK2.06054326
18EEF2K1.98049792
19MAPK151.75674580
20ICK1.71909847
21MKNK21.71795215
22MAP4K21.70941585
23WNK11.59302667
24MAP2K21.58279852
25TNIK1.56041847
26MAP3K31.55484981
27PNCK1.49386203
28EPHB11.47318134
29FRK1.45757607
30OXSR11.45550426
31PTK61.42696556
32BMPR1B1.42288124
33MAPKAPK51.39766775
34ERBB31.35377432
35EPHB21.33611681
36LATS11.33476896
37MUSK1.28553229
38NTRK31.26655759
39TRIM281.23056871
40PASK1.22618826
41MAPKAPK31.20883320
42PRKCI1.19254007
43WNK31.15720034
44PAK41.15519186
45GRK11.12855059
46TRPM71.10960825
47MAP3K121.10386933
48PINK11.08742660
49FGFR21.08522785
50BRSK21.07384904
51PRKG21.04847349
52MAP3K101.04542703
53NUAK11.03509568
54HIPK20.99685536
55IRAK10.96840419
56PRKCE0.96449044
57PBK0.96291699
58STK38L0.96272530
59DYRK1B0.94535401
60LRRK20.94379741
61NME10.92031828
62STK30.87995382
63PLK30.87121652
64IRAK20.85851460
65INSRR0.85326673
66BRD40.84148851
67CAMK1G0.83556123
68CSNK1G10.82853889
69CDK90.82426959
70YES10.81808560
71MAPK130.81305392
72RPS6KB20.81047526
73CDK120.80828374
74DDR20.80714498
75STK100.80555587
76CDC42BPA0.80343819
77TTN0.78821541
78EPHA20.78432312
79FER0.76106031
80TTK0.75525889
81RIPK10.75171523
82KSR20.74205959
83PLK20.72746220
84STK240.72183862
85TRIB30.71508307
86TGFBR20.71034957
87PHKG20.69411288
88PHKG10.69411288
89PRKD10.68242343
90PDGFRB0.67955043
91MYLK0.67429759
92CAMK2D0.66846171
93MAP3K40.65476716
94MARK10.65108707
95NLK0.64975143
96TAOK30.63635952
97PAK30.63614958
98ILK0.62893402
99NEK60.62211362
100MAP3K10.60484426
101PAK20.60227159
102RPS6KA40.58525544
103PLK10.57815178
104RPS6KB10.57287712
105NEK20.57036744
106MKNK10.56895347
107ITK0.56758991
108MARK20.55846947
109EPHA40.55225691
110MAP3K70.53669573
111ROCK10.53572710
112PTK20.53560095
113CSNK1A10.53370173
114CSNK1G30.53120204
115PRKCZ0.52821169
116CSNK1E0.52321080
117MAP3K80.52137891
118MTOR0.52046439
119AKT30.50627351
120PDK10.50212071
121SGK20.49417065
122GSK3A0.49135650
123BCR0.46815311
124DYRK20.45209982
125TGFBR10.44235886
126PTK2B0.43996973
127PRKCG0.43757099
128ROCK20.43205971
129ADRBK20.42677538
130TYRO30.41156002
131CSNK1D0.41012197
132FGFR10.39046162
133MAP2K10.38750776
134CSNK1G20.38334513
135TAOK10.38292157
136PIK3CG0.38193110
137PDPK10.37800464
138UHMK10.37690362
139ERBB20.36838010
140LIMK10.36362685
141CAMK1D0.35361883
142RET0.34452265
143TSSK60.34305101
144FGFR30.34268719
145PRKAA20.34177144
146PKN10.34150413
147DYRK30.34106599
148ATM0.34093553
149RPS6KA10.32539594
150ZAK0.31864910
151MAPKAPK20.31679211
152CHEK10.31406642
153PRKAA10.30939967
154PKN20.30753735
155MINK10.30602906
156ADRBK10.26641402
157TAF10.26320218
158CSNK1A1L0.25504325

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049783.05363437
2Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.72901328
3Protein digestion and absorption_Homo sapiens_hsa049742.61580658
4Phototransduction_Homo sapiens_hsa047442.53913299
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43385325
6ECM-receptor interaction_Homo sapiens_hsa045122.32987412
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14996109
8Sphingolipid metabolism_Homo sapiens_hsa006002.07110802
9Tight junction_Homo sapiens_hsa045302.06331113
10Caffeine metabolism_Homo sapiens_hsa002322.04503775
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04136291
12Butanoate metabolism_Homo sapiens_hsa006502.01412468
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00543778
14Linoleic acid metabolism_Homo sapiens_hsa005911.96051169
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.87945049
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83894523
17Propanoate metabolism_Homo sapiens_hsa006401.77609548
18Dorso-ventral axis formation_Homo sapiens_hsa043201.74998241
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.73796738
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72751146
21Fatty acid degradation_Homo sapiens_hsa000711.69911596
22Fatty acid metabolism_Homo sapiens_hsa012121.66071575
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65272844
24Hedgehog signaling pathway_Homo sapiens_hsa043401.63623294
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63316383
26Fat digestion and absorption_Homo sapiens_hsa049751.58121037
27Ether lipid metabolism_Homo sapiens_hsa005651.56802672
28Steroid biosynthesis_Homo sapiens_hsa001001.56648034
29Sulfur metabolism_Homo sapiens_hsa009201.56609005
30Tryptophan metabolism_Homo sapiens_hsa003801.55430858
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50322322
32Chemical carcinogenesis_Homo sapiens_hsa052041.48803187
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.48221233
34Adherens junction_Homo sapiens_hsa045201.46438365
35Thyroid hormone synthesis_Homo sapiens_hsa049181.45053004
36Histidine metabolism_Homo sapiens_hsa003401.43267797
37Hippo signaling pathway_Homo sapiens_hsa043901.41675199
38Basal cell carcinoma_Homo sapiens_hsa052171.40670769
39Gastric acid secretion_Homo sapiens_hsa049711.37435677
40Pancreatic secretion_Homo sapiens_hsa049721.36764647
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.35030538
42Thyroid cancer_Homo sapiens_hsa052161.34948048
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34302315
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33387865
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32220499
46Retinol metabolism_Homo sapiens_hsa008301.31945499
47Renin-angiotensin system_Homo sapiens_hsa046141.26032418
48Small cell lung cancer_Homo sapiens_hsa052221.23759829
49Folate biosynthesis_Homo sapiens_hsa007901.23548901
50Focal adhesion_Homo sapiens_hsa045101.23021620
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22697279
52Dilated cardiomyopathy_Homo sapiens_hsa054141.16987712
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12604393
54Peroxisome_Homo sapiens_hsa041461.12319553
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11704129
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11687148
57Protein export_Homo sapiens_hsa030601.11558319
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.11459540
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11142524
60Wnt signaling pathway_Homo sapiens_hsa043101.10738062
61Nitrogen metabolism_Homo sapiens_hsa009101.10216334
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08625375
63ABC transporters_Homo sapiens_hsa020101.06835613
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04497151
65Inositol phosphate metabolism_Homo sapiens_hsa005621.01894825
66Starch and sucrose metabolism_Homo sapiens_hsa005001.01578323
67N-Glycan biosynthesis_Homo sapiens_hsa005101.01041423
68Glutathione metabolism_Homo sapiens_hsa004801.00472556
69Bladder cancer_Homo sapiens_hsa052190.99009350
70Insulin secretion_Homo sapiens_hsa049110.98479310
71Selenocompound metabolism_Homo sapiens_hsa004500.98138077
72Melanogenesis_Homo sapiens_hsa049160.95109454
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94781115
74Renin secretion_Homo sapiens_hsa049240.94762491
75Glucagon signaling pathway_Homo sapiens_hsa049220.92662669
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.92482790
77Arachidonic acid metabolism_Homo sapiens_hsa005900.92342213
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91472391
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91443313
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91163976
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.90837542
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90151258
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89973719
84Proteoglycans in cancer_Homo sapiens_hsa052050.88457228
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86783219
86Lysine degradation_Homo sapiens_hsa003100.85504795
87Arginine and proline metabolism_Homo sapiens_hsa003300.85328505
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81803400
89Salivary secretion_Homo sapiens_hsa049700.81399887
90Glycerolipid metabolism_Homo sapiens_hsa005610.79696654
91Estrogen signaling pathway_Homo sapiens_hsa049150.77157333
92Pathways in cancer_Homo sapiens_hsa052000.76528867
93Arginine biosynthesis_Homo sapiens_hsa002200.76159915
94Ovarian steroidogenesis_Homo sapiens_hsa049130.75692027
95Vitamin digestion and absorption_Homo sapiens_hsa049770.75317070
96PPAR signaling pathway_Homo sapiens_hsa033200.74685921
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74657966
98Pyruvate metabolism_Homo sapiens_hsa006200.74159957
99Cardiac muscle contraction_Homo sapiens_hsa042600.73978870
100Renal cell carcinoma_Homo sapiens_hsa052110.73305736
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72467494
102beta-Alanine metabolism_Homo sapiens_hsa004100.72053465
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.71990608
104cAMP signaling pathway_Homo sapiens_hsa040240.70937846
105Phenylalanine metabolism_Homo sapiens_hsa003600.68722386
106Basal transcription factors_Homo sapiens_hsa030220.67902181
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66975289
108Metabolic pathways_Homo sapiens_hsa011000.65672789
109Prostate cancer_Homo sapiens_hsa052150.65339714
110TGF-beta signaling pathway_Homo sapiens_hsa043500.65312352
111Regulation of autophagy_Homo sapiens_hsa041400.65298595
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64731562
113Endometrial cancer_Homo sapiens_hsa052130.61573190
114Fatty acid elongation_Homo sapiens_hsa000620.61503811
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61422635
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59556299
117Bile secretion_Homo sapiens_hsa049760.58235909
118Fanconi anemia pathway_Homo sapiens_hsa034600.57869841
119Amoebiasis_Homo sapiens_hsa051460.57358522
120Tyrosine metabolism_Homo sapiens_hsa003500.56413564
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56321710
122Type II diabetes mellitus_Homo sapiens_hsa049300.56213150
123Cocaine addiction_Homo sapiens_hsa050300.55671061
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.55179725
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.54451038
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53908477
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53682808
128Taste transduction_Homo sapiens_hsa047420.53678274
129MicroRNAs in cancer_Homo sapiens_hsa052060.53421526
130Long-term depression_Homo sapiens_hsa047300.53057292
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51951380
132Ras signaling pathway_Homo sapiens_hsa040140.50321068
133VEGF signaling pathway_Homo sapiens_hsa043700.50012245
134Notch signaling pathway_Homo sapiens_hsa043300.48738464
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48620459
136Platelet activation_Homo sapiens_hsa046110.48264112
137Axon guidance_Homo sapiens_hsa043600.47939847
138Circadian rhythm_Homo sapiens_hsa047100.47565658
139Fatty acid biosynthesis_Homo sapiens_hsa000610.45694871
140Alcoholism_Homo sapiens_hsa050340.45515704
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44517693
142Toxoplasmosis_Homo sapiens_hsa051450.44322543
143GnRH signaling pathway_Homo sapiens_hsa049120.43540726
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.42513869
145Non-homologous end-joining_Homo sapiens_hsa034500.42259929
146Insulin resistance_Homo sapiens_hsa049310.42016482
147Oocyte meiosis_Homo sapiens_hsa041140.41301300
148Choline metabolism in cancer_Homo sapiens_hsa052310.41288184
149ErbB signaling pathway_Homo sapiens_hsa040120.41285237
150Pancreatic cancer_Homo sapiens_hsa052120.41131100
151Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40219342
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38952801
153Fructose and mannose metabolism_Homo sapiens_hsa000510.38443442
154Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33854896
155RNA polymerase_Homo sapiens_hsa030200.31613468
156Galactose metabolism_Homo sapiens_hsa000520.31309826

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