LRRC10B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.78778680
2left/right pattern formation (GO:0060972)9.03705180
3primary alcohol catabolic process (GO:0034310)7.80363195
4regulation of cilium movement (GO:0003352)7.48495503
5vitamin transmembrane transport (GO:0035461)6.76205792
6left/right axis specification (GO:0070986)6.43521195
7microtubule bundle formation (GO:0001578)6.41080325
8ethanol metabolic process (GO:0006067)6.38658812
9ventricular system development (GO:0021591)6.35549344
10intraciliary transport (GO:0042073)6.19694398
11diterpenoid biosynthetic process (GO:0016102)5.98682444
12cilium organization (GO:0044782)5.82471523
13cilium assembly (GO:0042384)5.69344925
14lung epithelium development (GO:0060428)5.62215006
15regulation of synapse structural plasticity (GO:0051823)5.34027316
16synaptic transmission, dopaminergic (GO:0001963)5.22928741
17one-carbon compound transport (GO:0019755)5.15267266
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.10019705
19pyrimidine-containing compound transmembrane transport (GO:0072531)5.08337521
20tolerance induction (GO:0002507)5.05076133
21adenosine receptor signaling pathway (GO:0001973)4.99998637
22establishment of apical/basal cell polarity (GO:0035089)4.97678131
23ethanol oxidation (GO:0006069)4.97113421
24centriole assembly (GO:0098534)4.94323508
25locomotory exploration behavior (GO:0035641)4.88538244
26protein localization to cilium (GO:0061512)4.84408289
27prepulse inhibition (GO:0060134)4.76334615
28negative regulation of T cell differentiation in thymus (GO:0033085)4.75775273
29negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.69019955
30response to xenobiotic stimulus (GO:0009410)4.68402508
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.67603749
32sperm capacitation (GO:0048240)4.66528616
33regulation of short-term neuronal synaptic plasticity (GO:0048172)4.66196139
34glomerular epithelial cell development (GO:0072310)4.64581311
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63181452
36striatum development (GO:0021756)4.61364130
37synaptic vesicle maturation (GO:0016188)4.57344814
38regulation of microtubule-based movement (GO:0060632)4.56509440
39establishment or maintenance of monopolar cell polarity (GO:0061339)4.54046437
40establishment of monopolar cell polarity (GO:0061162)4.54046437
41negative regulation of B cell mediated immunity (GO:0002713)4.53727521
42negative regulation of immunoglobulin mediated immune response (GO:0002890)4.53727521
43cellular component assembly involved in morphogenesis (GO:0010927)4.53580614
44microtubule-based movement (GO:0007018)4.53510997
45adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.49926363
46negative regulation of humoral immune response (GO:0002921)4.40819002
47regulation of long-term neuronal synaptic plasticity (GO:0048169)4.40074538
48positive regulation of synaptic transmission, GABAergic (GO:0032230)4.33655790
49terpenoid biosynthetic process (GO:0016114)4.30804322
50regulation of neuronal synaptic plasticity (GO:0048168)4.30328786
51retinoic acid metabolic process (GO:0042573)4.28583382
52auditory behavior (GO:0031223)4.28120564
53response to amphetamine (GO:0001975)4.25957591
54regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.24835053
55vocalization behavior (GO:0071625)4.22388704
56cilium morphogenesis (GO:0060271)4.20602034
57regulation of glutamate receptor signaling pathway (GO:1900449)4.19995890
58regulation of interleukin-5 production (GO:0032674)4.15992744
59negative regulation of cytosolic calcium ion concentration (GO:0051481)4.15000669
60cell projection assembly (GO:0030031)4.14949064
61cAMP catabolic process (GO:0006198)4.08765744
62synaptic vesicle docking involved in exocytosis (GO:0016081)4.07113466
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.07041585
64regulation of synaptic vesicle exocytosis (GO:2000300)4.01947876
65regulation of germinal center formation (GO:0002634)3.98762466
66neurotransmitter-gated ion channel clustering (GO:0072578)3.98228601
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.94165050
68positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.92540931
69positive regulation of tolerance induction (GO:0002645)3.91977164
70positive regulation of neurotransmitter transport (GO:0051590)3.87917707
71dopamine receptor signaling pathway (GO:0007212)3.84134939
72regulation of interleukin-13 production (GO:0032656)3.83424810
73cyclic nucleotide catabolic process (GO:0009214)3.83362783
74response to auditory stimulus (GO:0010996)3.79643391
75regulation of female receptivity (GO:0045924)3.77202796
76cytoplasmic microtubule organization (GO:0031122)3.74835955
77synaptic vesicle exocytosis (GO:0016079)3.74775869
78G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.72866833
79ionotropic glutamate receptor signaling pathway (GO:0035235)3.69192538
80long-term memory (GO:0007616)3.67648951
81regulation of synaptic vesicle transport (GO:1902803)3.67170260
82nucleoside diphosphate phosphorylation (GO:0006165)3.66252077
83neuron-neuron synaptic transmission (GO:0007270)3.64918965
84regulation of dendritic spine morphogenesis (GO:0061001)3.63597909
85positive regulation of membrane potential (GO:0045838)3.63248494
86behavioral response to cocaine (GO:0048148)3.59530272
87female mating behavior (GO:0060180)3.58921729
88neuronal ion channel clustering (GO:0045161)3.56809473
89transmission of nerve impulse (GO:0019226)3.53811934
90synaptic transmission, glutamatergic (GO:0035249)3.53170310
91positive regulation of neurotransmitter secretion (GO:0001956)3.53063952
92neuromuscular process controlling balance (GO:0050885)3.52134102
93establishment of planar polarity (GO:0001736)3.52082895
94establishment of tissue polarity (GO:0007164)3.52082895
95regulation of norepinephrine secretion (GO:0014061)3.49940778
96regulation of excitatory postsynaptic membrane potential (GO:0060079)3.49055471
97regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.45567117
98regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.45567117
99regulation of synaptic transmission, glutamatergic (GO:0051966)3.45335650
100dendritic spine morphogenesis (GO:0060997)3.45110324
101exploration behavior (GO:0035640)3.42932364
102activation of protein kinase A activity (GO:0034199)3.42601465
103neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.42485145
104neuronal action potential propagation (GO:0019227)3.42245826
105negative regulation of inclusion body assembly (GO:0090084)3.41647681
106microtubule depolymerization (GO:0007019)3.41445922
107regulation of synaptic plasticity (GO:0048167)3.39263033
108retinol metabolic process (GO:0042572)3.37868703
109regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.37637121
110detection of calcium ion (GO:0005513)3.37341431
111neurotransmitter secretion (GO:0007269)3.37128634
112substrate-independent telencephalic tangential migration (GO:0021826)3.37112844
113substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.37112844
114regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36261631
115cAMP metabolic process (GO:0046058)3.34240738
116primary alcohol metabolic process (GO:0034308)3.34216090
117protein localization to synapse (GO:0035418)3.29788356
118microtubule polymerization or depolymerization (GO:0031109)3.29439276
119negative regulation of catecholamine secretion (GO:0033604)3.26679137
120exogenous drug catabolic process (GO:0042738)3.25680923
121regulation of neurotransmitter uptake (GO:0051580)3.25027776
122mechanosensory behavior (GO:0007638)3.23987304
123lateral ventricle development (GO:0021670)3.23958162
124regulation of postsynaptic membrane potential (GO:0060078)3.23321689
125visual learning (GO:0008542)3.22988753
126long-term synaptic potentiation (GO:0060291)3.22884208
127positive regulation of smoothened signaling pathway (GO:0045880)3.21526374
128regulation of glutamate secretion (GO:0014048)3.15127952
129phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.13002720
130glutamate receptor signaling pathway (GO:0007215)3.12248223
131peristalsis (GO:0030432)3.10746099
132glutathione derivative biosynthetic process (GO:1901687)3.10356782
133glutathione derivative metabolic process (GO:1901685)3.10356782
134regulation of synaptic transmission, GABAergic (GO:0032228)3.06113026
135O-glycan processing (GO:0016266)3.04384462
136visual behavior (GO:0007632)3.04298968
137behavioral fear response (GO:0001662)3.04287735
138behavioral defense response (GO:0002209)3.04287735
139hydrogen peroxide biosynthetic process (GO:0050665)3.03333491
140membrane hyperpolarization (GO:0060081)3.00964774
141axonemal dynein complex assembly (GO:0070286)21.4056718
142glutamate secretion (GO:0014047)2.99774557
143cAMP biosynthetic process (GO:0006171)2.99194639
144long term synaptic depression (GO:0060292)2.98513274
145apical protein localization (GO:0045176)2.98149549
146membrane depolarization during action potential (GO:0086010)2.97507731
147chemosensory behavior (GO:0007635)2.97300698
148regulation of microtubule depolymerization (GO:0031114)2.96763598
149multicellular organismal water homeostasis (GO:0050891)2.96413234
150regulation of Rap GTPase activity (GO:0032317)2.94370817
151aldehyde catabolic process (GO:0046185)2.93297042
152behavioral response to ethanol (GO:0048149)2.92442533
153sperm motility (GO:0030317)2.92381886
154serotonin metabolic process (GO:0042428)2.92323288
155drinking behavior (GO:0042756)2.91743020
156learning (GO:0007612)2.90450854
157dendritic spine organization (GO:0097061)2.90351757
158fear response (GO:0042596)2.90225547
159response to histamine (GO:0034776)2.87913092
160regulation of voltage-gated calcium channel activity (GO:1901385)2.87615468
161regulation of neurotransmitter transport (GO:0051588)2.86682674
162negative regulation of amine transport (GO:0051953)2.86040393
163smoothened signaling pathway (GO:0007224)2.85820873
164lateral sprouting from an epithelium (GO:0060601)2.85439976
165positive regulation of synaptic transmission (GO:0050806)2.84389391
166membrane depolarization (GO:0051899)2.84047778
167regulation of tolerance induction (GO:0002643)2.81941114
168determination of left/right symmetry (GO:0007368)2.77398989
169progesterone metabolic process (GO:0042448)2.77071721
170microtubule-based process (GO:0007017)2.70549165
171carnitine metabolic process (GO:0009437)2.70230631
172reactive oxygen species biosynthetic process (GO:1903409)2.67149837
173ear development (GO:0043583)2.67090320
174determination of bilateral symmetry (GO:0009855)2.66955452
175regulation of autophagic vacuole assembly (GO:2000785)2.64830195
176hydrogen peroxide catabolic process (GO:0042744)2.63638947
177oligosaccharide biosynthetic process (GO:0009312)2.62821805
178retinal rod cell development (GO:0046548)2.62073357
179specification of symmetry (GO:0009799)2.60682245
180phosphatidylcholine biosynthetic process (GO:0006656)2.58573856
181centriole replication (GO:0007099)2.57182027
182excretion (GO:0007588)2.57179541
183calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.55539089
184establishment or maintenance of bipolar cell polarity (GO:0061245)2.54261239
185establishment or maintenance of apical/basal cell polarity (GO:0035088)2.54261239
186regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.53766215
187drug catabolic process (GO:0042737)2.53758575
188water homeostasis (GO:0030104)2.52004165
189sodium ion homeostasis (GO:0055078)2.49990894
190organelle assembly (GO:0070925)2.49415159
191phenol-containing compound catabolic process (GO:0019336)2.43629751
192negative regulation of microtubule depolymerization (GO:0007026)2.39304585
193nonmotile primary cilium assembly (GO:0035058)2.38733644
194CDP-diacylglycerol biosynthetic process (GO:0016024)2.36189837
195cilium or flagellum-dependent cell motility (GO:0001539)16.7317579
196cilium movement (GO:0003341)14.8805350
197motile cilium assembly (GO:0044458)14.1750237
198epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.3473717
199epithelial cilium movement (GO:0003351)12.9968906

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.26416518
2EZH2_22144423_ChIP-Seq_EOC_Human5.22290231
3* RARB_27405468_Chip-Seq_BRAIN_Mouse3.39056698
4GBX2_23144817_ChIP-Seq_PC3_Human3.28993722
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.93840923
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89938221
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79764641
8REST_21632747_ChIP-Seq_MESCs_Mouse2.70867386
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70754071
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.69713846
11DROSHA_22980978_ChIP-Seq_HELA_Human2.67634371
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54642833
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.52664246
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51320166
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44233377
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42703819
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42703819
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40395139
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38638075
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.29954421
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21611063
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.19320951
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11798705
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10625678
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.09323273
26* RNF2_27304074_Chip-Seq_ESCs_Mouse2.04946374
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.94374561
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.93911036
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.93279706
30RUNX1_27514584_Chip-Seq_MCF-7_Human1.82297733
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.82066123
32* SMC4_20622854_ChIP-Seq_HELA_Human1.80786118
33* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80618125
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73507859
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69762381
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.67198385
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.66373721
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62660168
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60693263
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60210240
41FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.59391940
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52339858
43STAT1_20625510_ChIP-Seq_HELA_Human1.51006557
44SMAD4_21799915_ChIP-Seq_A2780_Human1.49334170
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45661168
46* TP63_22573176_ChIP-Seq_HFKS_Human1.43627179
47AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.42879672
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42266630
49KLF5_25053715_ChIP-Seq_YYC3_Human1.41847199
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40755599
51RAD21_21589869_ChIP-Seq_MESCs_Mouse1.40401059
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40015213
53TDRD3_21172665_ChIP-Seq_MCF-7_Human1.38863284
54AR_21572438_ChIP-Seq_LNCaP_Human1.37637606
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35820917
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34893007
57* TP63_23658742_ChIP-Seq_EP156T_Human1.34311392
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33955420
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33568978
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.32075900
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31727136
62STAT3_23295773_ChIP-Seq_U87_Human1.31529457
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30812587
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.30535246
65CDX2_20551321_ChIP-Seq_CACO-2_Human1.30329959
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.30083208
67VDR_22108803_ChIP-Seq_LS180_Human1.29616708
68P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29125931
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28882386
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28404154
71SOX2_20726797_ChIP-Seq_SW620_Human1.27533454
72* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24948723
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23538266
74FOXA1_25552417_ChIP-Seq_VCAP_Human1.23039008
75AR_19668381_ChIP-Seq_PC3_Human1.22283229
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.22234595
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22119427
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20550979
79TP53_18474530_ChIP-ChIP_U2OS_Human1.19600515
80* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19487579
81P300_19829295_ChIP-Seq_ESCs_Human1.18610639
82* P68_20966046_ChIP-Seq_HELA_Human1.17260389
83* RING1B_27294783_Chip-Seq_ESCs_Mouse1.16742387
84ETV1_20927104_ChIP-Seq_GIST48_Human1.16545054
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16276904
86KDM2B_26808549_Chip-Seq_K562_Human1.15890139
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15463971
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14026393
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12982262
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12399105
91* CREB1_26743006_Chip-Seq_LNCaP_Human1.11463563
92PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10752791
93TCF4_23295773_ChIP-Seq_U87_Human1.10660034
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.10283127
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10282809
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09957186
97PHF8_20622853_ChIP-Seq_HELA_Human1.09335761
98* CTCF_20526341_ChIP-Seq_ESCs_Human1.08713786
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.08664725
100CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07505546
101* RACK7_27058665_Chip-Seq_MCF-7_Human1.06718828
102CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06424522
103TAF15_26573619_Chip-Seq_HEK293_Human1.06240955
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06235929
105HNFA_21074721_ChIP-Seq_CACO-2_Human1.06141521
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05847654
107YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05155105
108AR_25329375_ChIP-Seq_VCAP_Human1.04721402
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03796165
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03745251
111YY1_22570637_ChIP-Seq_MALME-3M_Human1.03744816
112DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03628850
113SMAD3_21741376_ChIP-Seq_HESCs_Human1.03446977
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03179193
115SMRT_27268052_Chip-Seq_Bcells_Human1.03174200
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.02541752
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02394479
118PHF8_20622854_ChIP-Seq_HELA_Human1.02181465
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02102230
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02020244
121RUNX2_22187159_ChIP-Seq_PCA_Human1.01732318
122SMAD3_21741376_ChIP-Seq_ESCs_Human1.01723734
123LXR_22292898_ChIP-Seq_THP-1_Human1.01521335
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01295774
125EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00561991
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99810872
127GATA1_19941826_ChIP-Seq_K562_Human0.99695799
128RBPJ_21746931_ChIP-Seq_IB4_Human0.99439870
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99100106
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96912035
131CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96077847
132CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96056583
133AHR_22903824_ChIP-Seq_MCF-7_Human0.95144313
134FOXA2_19822575_ChIP-Seq_HepG2_Human0.94817188
135GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94055600
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93861084
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.93414020
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93341321
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.93166644
140PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92876836
141RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92866506
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92212569
143* CTCF_27219007_Chip-Seq_Bcells_Human0.91865748
144ARNT_22903824_ChIP-Seq_MCF-7_Human0.91275156
145GATA6_21074721_ChIP-Seq_CACO-2_Human0.89998446
146BCAT_22108803_ChIP-Seq_LS180_Human0.89503593
147NFYA_21822215_ChIP-Seq_K562_Human0.89439072
148* RXR_22108803_ChIP-Seq_LS180_Human0.88819153
149RNF2_27304074_Chip-Seq_NSC_Mouse0.88617795
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88198967
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87646979
152FLI1_21867929_ChIP-Seq_CD8_Mouse0.87283819
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87171627
154TBL1_22424771_ChIP-Seq_293T_Human0.86526834
155CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86460759
156CBX2_27304074_Chip-Seq_ESCs_Mouse0.86319534
157TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85769741
158SOX2_21211035_ChIP-Seq_LN229_Human0.85731857
159SMAD_19615063_ChIP-ChIP_OVARY_Human0.85512309
160GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85186597
161MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85054166
162OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84903934
163E2F1_20622854_ChIP-Seq_HELA_Human0.84662666
164DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84169464
165NANOG_18555785_Chip-Seq_ESCs_Mouse0.83959595
166* KLF4_19829295_ChIP-Seq_ESCs_Human0.83609991
167NFYB_21822215_ChIP-Seq_K562_Human0.83112008
168GATA4_25053715_ChIP-Seq_YYC3_Human0.82782677
169FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82446192
170EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82330356
171ZNF263_19887448_ChIP-Seq_K562_Human0.82269198
172SA1_27219007_Chip-Seq_ERYTHROID_Human0.82128904
173WDR5_24793694_ChIP-Seq_LNCAP_Human0.81187000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy7.54834465
2MP0008875_abnormal_xenobiotic_pharmacok6.59961369
3MP0002653_abnormal_ependyma_morphology6.36644533
4MP0004859_abnormal_synaptic_plasticity5.60178831
5MP0002132_abnormal_respiratory_system4.43212058
6MP0003635_abnormal_synaptic_transmissio3.65764907
7MP0004133_heterotaxia3.61393539
8MP0002909_abnormal_adrenal_gland3.56809756
9MP0003880_abnormal_central_pattern3.42356159
10MP0000566_synostosis3.41258874
11MP0002277_abnormal_respiratory_mucosa3.26063512
12MP0008789_abnormal_olfactory_epithelium3.24065796
13MP0009745_abnormal_behavioral_response3.18605796
14MP0002063_abnormal_learning/memory/cond3.11065507
15MP0004270_analgesia3.10206009
16MP0005646_abnormal_pituitary_gland3.02638795
17MP0005623_abnormal_meninges_morphology2.94275232
18MP0009780_abnormal_chondrocyte_physiolo2.59470959
19MP0002572_abnormal_emotion/affect_behav2.56338687
20MP0002064_seizures2.56228083
21MP0005377_hearing/vestibular/ear_phenot2.50361711
22MP0003878_abnormal_ear_physiology2.50361711
23MP0001486_abnormal_startle_reflex2.48944540
24MP0003283_abnormal_digestive_organ2.31042614
25MP0002272_abnormal_nervous_system2.29880216
26MP0004019_abnormal_vitamin_homeostasis2.24768725
27MP0001529_abnormal_vocalization2.23065838
28MP0009046_muscle_twitch2.15306934
29MP0001984_abnormal_olfaction2.15299531
30MP0005423_abnormal_somatic_nervous2.04541988
31MP0001501_abnormal_sleep_pattern1.96898862
32MP0001968_abnormal_touch/_nociception1.94112242
33MP0002734_abnormal_mechanical_nocicepti1.93603025
34MP0000383_abnormal_hair_follicle1.92683470
35MP0000013_abnormal_adipose_tissue1.91816335
36MP0003879_abnormal_hair_cell1.89260545
37MP0010678_abnormal_skin_adnexa1.82489837
38MP0004043_abnormal_pH_regulation1.81896289
39MP0002168_other_aberrant_phenotype1.80599156
40MP0010234_abnormal_vibrissa_follicle1.78376095
41MP0002160_abnormal_reproductive_system1.74178755
42MP0002282_abnormal_trachea_morphology1.73724373
43MP0002557_abnormal_social/conspecific_i1.70507952
44MP0005248_abnormal_Harderian_gland1.69796172
45MP0001970_abnormal_pain_threshold1.63637958
46MP0001188_hyperpigmentation1.63068188
47MP0002249_abnormal_larynx_morphology1.62256109
48MP0002733_abnormal_thermal_nociception1.61234392
49MP0010386_abnormal_urinary_bladder1.57548594
50MP0005386_behavior/neurological_phenoty1.56630682
51MP0004924_abnormal_behavior1.56630682
52MP0005645_abnormal_hypothalamus_physiol1.54812191
53MP0005409_darkened_coat_color1.52360340
54MP0004811_abnormal_neuron_physiology1.50352871
55MP0005083_abnormal_biliary_tract1.49319057
56MP0003136_yellow_coat_color1.48882905
57MP0003656_abnormal_erythrocyte_physiolo1.47096120
58MP0002693_abnormal_pancreas_physiology1.44988226
59MP0002877_abnormal_melanocyte_morpholog1.44698036
60MP0008569_lethality_at_weaning1.44602800
61MP0001440_abnormal_grooming_behavior1.44442668
62MP0003787_abnormal_imprinting1.42279887
63MP0001346_abnormal_lacrimal_gland1.39043641
64MP0008961_abnormal_basal_metabolism1.31936797
65MP0004885_abnormal_endolymph1.29012295
66MP0001177_atelectasis1.28318960
67MP0002067_abnormal_sensory_capabilities1.26680553
68MP0003633_abnormal_nervous_system1.26011232
69MP0002736_abnormal_nociception_after1.25771164
70MP0003075_altered_response_to1.25104822
71MP0009379_abnormal_foot_pigmentation1.22928146
72MP0002735_abnormal_chemical_nociception1.21553555
73MP0001502_abnormal_circadian_rhythm1.19067915
74MP0001944_abnormal_pancreas_morphology1.18459971
75MP0002184_abnormal_innervation1.16737144
76MP0000955_abnormal_spinal_cord1.16677385
77MP0005535_abnormal_body_temperature1.16288017
78MP0002066_abnormal_motor_capabilities/c1.12819006
79MP0005636_abnormal_mineral_homeostasis1.09861367
80MP0004085_abnormal_heartbeat1.08605303
81MP0004858_abnormal_nervous_system1.07207415
82MP0005379_endocrine/exocrine_gland_phen1.06479705
83MP0003183_abnormal_peptide_metabolism1.05776843
84MP0010030_abnormal_orbit_morphology1.05303344
85MP0000678_abnormal_parathyroid_gland1.02994604
86MP0002882_abnormal_neuron_morphology1.02489186
87MP0005395_other_phenotype1.02389791
88MP0002069_abnormal_eating/drinking_beha1.01031011
89MP0005167_abnormal_blood-brain_barrier1.00619669
90MP0005165_increased_susceptibility_to1.00432812
91MP0000631_abnormal_neuroendocrine_gland1.00214440
92MP0002233_abnormal_nose_morphology0.98719319
93MP0001485_abnormal_pinna_reflex0.97960185
94MP0008874_decreased_physiological_sensi0.94178611
95MP0001905_abnormal_dopamine_level0.92651730
96MP0003172_abnormal_lysosome_physiology0.91402449
97MP0000026_abnormal_inner_ear0.88064973
98MP0002638_abnormal_pupillary_reflex0.87931162
99MP0003631_nervous_system_phenotype0.86606951
100MP0005220_abnormal_exocrine_pancreas0.85443430
101MP0000569_abnormal_digit_pigmentation0.85053348
102MP0000465_gastrointestinal_hemorrhage0.84661699
103MP0003122_maternal_imprinting0.84649185
104MP0002078_abnormal_glucose_homeostasis0.83363066
105MP0006276_abnormal_autonomic_nervous0.83342316
106MP0000778_abnormal_nervous_system0.81205388
107MP0002098_abnormal_vibrissa_morphology0.80843808
108MP0001986_abnormal_taste_sensitivity0.80708144
109MP0005389_reproductive_system_phenotype0.80208987
110MP0002234_abnormal_pharynx_morphology0.79639818
111MP0003329_amyloid_beta_deposits0.79066235
112MP0001849_ear_inflammation0.78863454
113MP0001765_abnormal_ion_homeostasis0.78840785
114MP0008872_abnormal_physiological_respon0.78701026
115MP0002090_abnormal_vision0.77214658
116MP0001664_abnormal_digestion0.76955938
117MP0003698_abnormal_male_reproductive0.76788668
118MP0000003_abnormal_adipose_tissue0.76231680
119MP0002229_neurodegeneration0.74838828
120MP0002152_abnormal_brain_morphology0.74641711
121MP0010155_abnormal_intestine_physiology0.73956941
122MP0000681_abnormal_thyroid_gland0.72918253
123MP0004264_abnormal_extraembryonic_tissu0.71724205
124MP0009643_abnormal_urine_homeostasis0.71536119
125MP0005394_taste/olfaction_phenotype0.71244539
126MP0005499_abnormal_olfactory_system0.71244539
127MP0003690_abnormal_glial_cell0.70445140
128MP0001929_abnormal_gametogenesis0.70382833
129MP0002837_dystrophic_cardiac_calcinosis0.69899637
130MP0003300_gastrointestinal_ulcer0.69529406
131MP0005310_abnormal_salivary_gland0.67500018
132MP0003634_abnormal_glial_cell0.66953860
133MP0001293_anophthalmia0.66476259
134MP0003953_abnormal_hormone_level0.65749754
135MP0004742_abnormal_vestibular_system0.64881517
136MP0003942_abnormal_urinary_system0.64676618
137MP0002116_abnormal_craniofacial_bone0.64598925
138MP0002136_abnormal_kidney_physiology0.63592445
139MP0001324_abnormal_eye_pigmentation0.63313662
140MP0003861_abnormal_nervous_system0.63247696
141MP0003045_fibrosis0.62983481
142MP0005253_abnormal_eye_physiology0.62549769
143MP0005195_abnormal_posterior_eye0.61906890
144MP0003137_abnormal_impulse_conducting0.61650534
145MP0002876_abnormal_thyroid_physiology0.60270027
146MP0003890_abnormal_embryonic-extraembry0.60210310
147MP0001270_distended_abdomen0.58933685
148MP0005551_abnormal_eye_electrophysiolog0.58775706
149MP0001963_abnormal_hearing_physiology0.58251058
150MP0001299_abnormal_eye_distance/0.55741324
151MP0003938_abnormal_ear_development0.54994510
152MP0005408_hypopigmentation0.54614128
153MP0004145_abnormal_muscle_electrophysio0.54401909
154MP0005365_abnormal_bile_salt0.54349329
155MP0003303_peritoneal_inflammation0.53579074
156MP0005391_vision/eye_phenotype0.51356205
157MP0009703_decreased_birth_body0.51145381
158MP0000049_abnormal_middle_ear0.51142437
159MP0003866_abnormal_defecation0.49855102
160MP0009765_abnormal_xenobiotic_induced0.48746364
161MP0002896_abnormal_bone_mineralization0.47439344
162MP0000467_abnormal_esophagus_morphology0.47122564

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.45581331
2Bronchiectasis (HP:0002110)7.37609735
3Nasal polyposis (HP:0100582)6.67992877
4Focal motor seizures (HP:0011153)6.63464405
5Abnormality of the nasal mucosa (HP:0000433)5.52679961
6Focal seizures (HP:0007359)4.57167220
7Infertility (HP:0000789)4.26036961
8Recurrent sinusitis (HP:0011108)4.25461773
9Bronchitis (HP:0012387)4.18890915
10Chronic sinusitis (HP:0011109)4.12104260
11Resting tremor (HP:0002322)4.10700385
12Male infertility (HP:0003251)3.92182224
13Visual hallucinations (HP:0002367)3.80969882
14Recurrent otitis media (HP:0000403)3.79730667
15Torticollis (HP:0000473)3.66828806
16Occipital encephalocele (HP:0002085)3.64369094
17Anxiety (HP:0000739)3.58814601
18Pancreatic fibrosis (HP:0100732)3.53806488
19True hermaphroditism (HP:0010459)3.44459308
20Action tremor (HP:0002345)3.41488790
21Ankle clonus (HP:0011448)3.40212053
22Prolonged QT interval (HP:0001657)3.32627359
23Depression (HP:0000716)3.28905737
24Febrile seizures (HP:0002373)3.27089315
25Epileptic encephalopathy (HP:0200134)3.24835296
26Papilledema (HP:0001085)3.23445397
27Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.21954501
28Absence seizures (HP:0002121)3.21798139
29Atelectasis (HP:0100750)3.19807914
30Generalized tonic-clonic seizures (HP:0002069)3.17747184
31Focal dystonia (HP:0004373)3.17090154
32Impaired vibration sensation in the lower limbs (HP:0002166)3.14511366
33Poor eye contact (HP:0000817)3.10615183
34Decreased circulating renin level (HP:0003351)3.09916834
35Ankyloglossia (HP:0010296)3.09646190
36Craniofacial dystonia (HP:0012179)3.06171989
37Atonic seizures (HP:0010819)3.00521281
38Hyperinsulinemic hypoglycemia (HP:0000825)3.00253381
39Annular pancreas (HP:0001734)3.00224949
40Chronic otitis media (HP:0000389)2.99995843
41Dialeptic seizures (HP:0011146)2.93269246
42Abnormal EKG (HP:0003115)2.90914316
43Cystic liver disease (HP:0006706)2.87653210
44Pancreatic cysts (HP:0001737)2.77264966
45Abnormality of midbrain morphology (HP:0002418)2.77215765
46Molar tooth sign on MRI (HP:0002419)2.77215765
47Nephronophthisis (HP:0000090)2.76199318
48Impaired social interactions (HP:0000735)2.75866179
49Abnormal social behavior (HP:0012433)2.75866179
50Broad-based gait (HP:0002136)2.75626223
51Epileptiform EEG discharges (HP:0011182)2.66396048
52Dysdiadochokinesis (HP:0002075)2.65407483
53Stereotypic behavior (HP:0000733)2.62412871
54Abnormal pancreas size (HP:0012094)2.62354594
55EEG with generalized epileptiform discharges (HP:0011198)2.60613909
56Impaired smooth pursuit (HP:0007772)2.56136979
57Atrioventricular block (HP:0001678)2.54938936
58Truncal ataxia (HP:0002078)2.51538972
59Limb hypertonia (HP:0002509)2.50393967
60Polygenic inheritance (HP:0010982)2.50214432
61Progressive cerebellar ataxia (HP:0002073)2.49799787
62Hypsarrhythmia (HP:0002521)2.49776279
63Postural instability (HP:0002172)2.47109926
64Dysmetria (HP:0001310)2.46810379
65Postaxial foot polydactyly (HP:0001830)2.46486148
66Supranuclear gaze palsy (HP:0000605)2.45616513
67Gaze-evoked nystagmus (HP:0000640)2.43333903
68Hypoglycemic seizures (HP:0002173)2.42332619
69Bundle branch block (HP:0011710)2.41643392
70Chronic hepatic failure (HP:0100626)2.35471135
71Megalencephaly (HP:0001355)2.34652166
72Heart block (HP:0012722)2.33636046
73Abnormality of oral frenula (HP:0000190)2.31610917
74Ventricular fibrillation (HP:0001663)2.27814171
75Scanning speech (HP:0002168)2.26419222
76Unilateral renal agenesis (HP:0000122)2.25391026
77Hyperkalemia (HP:0002153)2.24638693
78Urinary bladder sphincter dysfunction (HP:0002839)2.22443414
79Limb dystonia (HP:0002451)2.21071944
80Abnormality of ocular smooth pursuit (HP:0000617)2.20638895
81Abnormality of calcium-phosphate metabolism (HP:0100530)2.18565864
82Large for gestational age (HP:0001520)2.17363227
83Pointed chin (HP:0000307)2.15646240
84Abnormal ciliary motility (HP:0012262)2.13967367
85Abnormality of the renal medulla (HP:0100957)2.13408346
86Symptomatic seizures (HP:0011145)2.13179325
87Cortical visual impairment (HP:0100704)2.12746740
88Spinal canal stenosis (HP:0003416)2.12229624
89Bell-shaped thorax (HP:0001591)2.11678609
90Hyperventilation (HP:0002883)2.11306343
91Insulin-resistant diabetes mellitus (HP:0000831)2.11277060
92Bradykinesia (HP:0002067)2.11172889
93Abnormal atrioventricular conduction (HP:0005150)2.11040372
94Amblyopia (HP:0000646)2.10814838
95Abnormal eating behavior (HP:0100738)2.09649287
96Abnormal respiratory motile cilium physiology (HP:0012261)2.08000498
97Impaired vibratory sensation (HP:0002495)2.05790233
98Agitation (HP:0000713)2.05768373
99Anencephaly (HP:0002323)2.02933211
100Congenital hepatic fibrosis (HP:0002612)2.02578376
101Clonus (HP:0002169)2.01267203
102Absent/shortened dynein arms (HP:0200106)2.00630046
103Dynein arm defect of respiratory motile cilia (HP:0012255)2.00630046
104Spastic gait (HP:0002064)2.00093881
105Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5000080
106Abnormal respiratory motile cilium morphology (HP:0005938)11.2911204
107Abnormal respiratory epithelium morphology (HP:0012253)11.2911204
108Abnormality of renin-angiotensin system (HP:0000847)1.99855910
109Tubulointerstitial nephritis (HP:0001970)1.99567029
110Aplasia/Hypoplasia of the tongue (HP:0010295)1.97805430
111Intention tremor (HP:0002080)1.97209280
112Lower limb amyotrophy (HP:0007210)1.94740654
113Renal salt wasting (HP:0000127)1.92117909
114Male pseudohermaphroditism (HP:0000037)1.91795810
115Failure to thrive in infancy (HP:0001531)1.91198466
116Aplasia/Hypoplasia of the spleen (HP:0010451)1.88254315
117Chronic bronchitis (HP:0004469)1.87325464
118Abnormality of the pancreatic islet cells (HP:0006476)1.87322907
119Abnormality of endocrine pancreas physiology (HP:0012093)1.87322907
120Medial flaring of the eyebrow (HP:0010747)1.85555746
121Absent frontal sinuses (HP:0002688)1.83877346
122Dysmetric saccades (HP:0000641)1.83709845
123Rhinitis (HP:0012384)1.80779430
124Asplenia (HP:0001746)1.80488311
125Hyperactive renin-angiotensin system (HP:0000841)1.80191707
126Deep palmar crease (HP:0006191)1.78525182
127Hemiparesis (HP:0001269)1.78315762
128Incomplete penetrance (HP:0003829)1.77085736
129Gait imbalance (HP:0002141)1.76621724
130Urinary urgency (HP:0000012)1.76241234
131Increased circulating renin level (HP:0000848)1.75990342
132Neurofibrillary tangles (HP:0002185)1.75844689
133Pancreatic islet-cell hyperplasia (HP:0004510)1.75743050
134Absent eyebrow (HP:0002223)1.75569143
135Sclerocornea (HP:0000647)1.75481150
136Congenital primary aphakia (HP:0007707)1.74885252
137Abnormality of potassium homeostasis (HP:0011042)1.73819789
138Obstructive sleep apnea (HP:0002870)1.72222214
139Abnormality of the periventricular white matter (HP:0002518)1.71107029
140Furrowed tongue (HP:0000221)1.69552791
141Nephropathy (HP:0000112)1.66638526
142Postaxial hand polydactyly (HP:0001162)1.60257460
143Recurrent bronchitis (HP:0002837)1.60118342
144Tubular atrophy (HP:0000092)1.59348788
145Oculomotor apraxia (HP:0000657)1.58822517
146Hyperaldosteronism (HP:0000859)1.58448191
147Nephrogenic diabetes insipidus (HP:0009806)1.52795733
148Abnormality of chloride homeostasis (HP:0011422)1.46067987
149Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.40258902
150Hand muscle atrophy (HP:0009130)1.34540151
151Preaxial hand polydactyly (HP:0001177)1.33077340
152Short thorax (HP:0010306)1.32780913
153Fetal akinesia sequence (HP:0001989)1.31967500
154Median cleft lip (HP:0000161)1.29539462
155Abnormality of permanent molar morphology (HP:0011071)1.28741207
156Abnormality of the dental root (HP:0006486)1.28741207
157Taurodontia (HP:0000679)1.28741207
158Bifid scrotum (HP:0000048)1.26789684
159Hypokalemic alkalosis (HP:0001949)1.23726110
160Vaginal atresia (HP:0000148)1.20077141
161Genital tract atresia (HP:0001827)1.19475719
162Glucose intolerance (HP:0000833)1.18766924
163Abnormality of molar (HP:0011077)1.18119612
164Abnormality of molar morphology (HP:0011070)1.18119612
165Poor coordination (HP:0002370)1.17380990
166Hyponatremia (HP:0002902)1.17234687
167Short nail (HP:0001799)1.15692647
168Abnormality of the dental pulp (HP:0006479)1.14414615
169Absent rod-and cone-mediated responses on ERG (HP:0007688)1.13968290
170Tubulointerstitial abnormality (HP:0001969)1.13369835
171Short femoral neck (HP:0100864)1.12842024
172Abnormality of the distal phalanges of the toes (HP:0010182)1.12475120
173Stage 5 chronic kidney disease (HP:0003774)1.12339288
174Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.11297602
175Abnormality of the frontal sinuses (HP:0002687)1.10761561
176Decreased central vision (HP:0007663)1.05881517
177Polydipsia (HP:0001959)1.03760482
178Abnormal drinking behavior (HP:0030082)1.03760482
179Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.01000561
180Aplasia of the musculature (HP:0100854)1.00444089
181Stridor (HP:0010307)1.00075984
182Absent speech (HP:0001344)0.99327761
183Popliteal pterygium (HP:0009756)0.98879253
184Cone-rod dystrophy (HP:0000548)0.97669843
185Abnormality of dentin (HP:0010299)0.96237260
186Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)0.95643711
187Renal dysplasia (HP:0000110)0.93944063
188Distal upper limb amyotrophy (HP:0007149)0.93352339
189Upper limb amyotrophy (HP:0009129)0.93352339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.30549057
2MST45.15213884
3EPHA24.80732020
4NTRK34.43913665
5PRKD33.63217731
6RIPK42.71303276
7MAPKAPK32.57185166
8MAP3K92.54246978
9DAPK22.50167152
10EEF2K2.40766144
11MAP3K22.33699641
12NTRK12.19992360
13CAMKK12.19410866
14KSR22.07181937
15INSRR1.97785741
16SMG11.92279422
17STK241.90721269
18NME11.87663794
19EPHB11.82846090
20MINK11.77824999
21FES1.77229011
22CAMKK21.71583055
23MAP3K41.66502875
24ARAF1.56133039
25CDK51.54054069
26NTRK21.53946348
27TNIK1.50546663
28PNCK1.48357997
29PRPF4B1.47289169
30MAP3K131.44413684
31BMPR21.41099383
32CSK1.38978835
33TTK1.38484262
34SIK21.35333896
35DAPK11.33611756
36PAK61.29753625
37MAP2K71.28599298
38PRKCH1.26013691
39BCR1.25656551
40KSR11.24019885
41MAP3K31.20850185
42MARK11.17833252
43TAOK11.15973534
44MAP3K11.15940364
45SGK21.14945898
46PINK11.14560365
47LRRK21.13720407
48TESK11.13050843
49MARK21.12222747
50SGK4941.11849931
51SGK2231.11849931
52UHMK11.11637662
53EPHA31.09760285
54STK381.09034828
55HIPK21.05308487
56ICK1.04535317
57SGK31.00852754
58TRPM70.98542578
59PASK0.96819417
60CAMK2B0.95342191
61PRKCG0.93818563
62NEK60.90368809
63MAP3K70.88525125
64TAOK30.88516180
65TYRO30.84350450
66MAPK150.83445775
67RAF10.79534351
68PDPK10.78384739
69PDGFRA0.78275404
70CAMK2A0.77946338
71SGK10.77434041
72SIK30.76482850
73CAMK10.76207655
74ERBB20.76173351
75PRKCI0.75798789
76PRKD20.74865087
77TRIB30.74314378
78STK100.73976213
79FRK0.71923343
80CDC42BPA0.70719240
81STK110.70355662
82DMPK0.69992715
83GRK50.69882934
84RET0.69583712
85PRKCE0.67790484
86MAP2K40.67648321
87MST1R0.66760278
88TLK10.65145687
89CASK0.65089798
90PDK10.65071581
91BRAF0.60893667
92MAPK130.60558156
93WNK10.60070562
94AKT30.59284900
95RPS6KB20.58665179
96ERBB30.58475696
97CAMK2D0.57988815
98ALK0.56703627
99PTK2B0.56155273
100TNK20.55939161
101MAP3K120.55487179
102RPS6KA30.52314477
103TBK10.52235053
104CDK180.51881935
105MAPK100.51514252
106MAP2K10.50532128
107CDK150.50529965
108CDK140.49301516
109PRKCZ0.48833299
110PAK30.48531956
111RPS6KA20.48232724
112DYRK1B0.47967771
113FYN0.47286009
114CAMK40.44927416
115AURKA0.44888888
116LMTK20.44586106
117WNK40.43243413
118WNK30.43135552
119PRKCD0.43103028
120FGFR30.42808387
121PRKCQ0.42806903
122RIPK10.42488079
123BRSK10.40675347
124CDK11A0.40580401
125NLK0.39555831
126CSNK1A10.39473324
127STK390.38380774
128PRKAA20.38257781
129PHKG20.37528256
130PHKG10.37528256
131ROCK20.37507019
132PRKACA0.37130555
133PLK20.36578455
134PRKACG0.36576101
135CAMK2G0.36395514
136DYRK1A0.36295252
137PRKCB0.35426837
138FER0.33743807
139PRKCA0.33408121
140MAP2K20.32767323
141GRK60.31804179
142STK160.30296434
143MAPKAPK50.30055216
144ROCK10.29960174
145MAP3K110.29154656
146AKT20.26774194
147GRK10.25239752
148PTK60.24165209
149MAP3K60.23207007
150ILK0.21088707
151ADRBK10.20375706
152MUSK0.19700322
153STK38L0.19116713
154LATS10.18636835
155SRC0.17662920
156OXSR10.17270150
157PRKDC0.14320664

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.39062653
2Phenylalanine metabolism_Homo sapiens_hsa003604.97373178
3Histidine metabolism_Homo sapiens_hsa003404.50580840
4Chemical carcinogenesis_Homo sapiens_hsa052044.31968600
5Tyrosine metabolism_Homo sapiens_hsa003504.02209555
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.01486315
7Olfactory transduction_Homo sapiens_hsa047403.61916807
8beta-Alanine metabolism_Homo sapiens_hsa004103.06939919
9Amphetamine addiction_Homo sapiens_hsa050312.90905360
10Cocaine addiction_Homo sapiens_hsa050302.77626184
11Morphine addiction_Homo sapiens_hsa050322.76800761
12Circadian entrainment_Homo sapiens_hsa047132.70558948
13Insulin secretion_Homo sapiens_hsa049112.66202818
14GABAergic synapse_Homo sapiens_hsa047272.52209107
15Long-term potentiation_Homo sapiens_hsa047202.51765170
16Nicotine addiction_Homo sapiens_hsa050332.48369809
17Glutathione metabolism_Homo sapiens_hsa004802.44461985
18Huntingtons disease_Homo sapiens_hsa050162.39145839
19Dopaminergic synapse_Homo sapiens_hsa047282.36632460
20Synaptic vesicle cycle_Homo sapiens_hsa047212.34553193
21Glutamatergic synapse_Homo sapiens_hsa047242.32636318
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26193363
23Cholinergic synapse_Homo sapiens_hsa047252.20689821
24Retinol metabolism_Homo sapiens_hsa008302.16207084
25Maturity onset diabetes of the young_Homo sapiens_hsa049502.03869695
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.98761915
27Renin secretion_Homo sapiens_hsa049241.90439030
28Caffeine metabolism_Homo sapiens_hsa002321.87022923
29Taste transduction_Homo sapiens_hsa047421.86406331
30Salivary secretion_Homo sapiens_hsa049701.86246911
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.72703903
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65545179
33Type II diabetes mellitus_Homo sapiens_hsa049301.65078887
34Gastric acid secretion_Homo sapiens_hsa049711.64792149
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.63501940
36Serotonergic synapse_Homo sapiens_hsa047261.63333411
37Calcium signaling pathway_Homo sapiens_hsa040201.60777320
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55484441
39Sphingolipid metabolism_Homo sapiens_hsa006001.54395504
40Oxytocin signaling pathway_Homo sapiens_hsa049211.51585746
41Tight junction_Homo sapiens_hsa045301.48657346
42Linoleic acid metabolism_Homo sapiens_hsa005911.48334007
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47519143
44cAMP signaling pathway_Homo sapiens_hsa040241.41992902
45Type I diabetes mellitus_Homo sapiens_hsa049401.39122225
46Gap junction_Homo sapiens_hsa045401.33943377
47Fatty acid degradation_Homo sapiens_hsa000711.30405230
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.30097568
49Long-term depression_Homo sapiens_hsa047301.27888471
50GnRH signaling pathway_Homo sapiens_hsa049121.25498685
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23845745
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23805679
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19786732
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16523596
55Peroxisome_Homo sapiens_hsa041461.11960415
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11856015
57Pancreatic secretion_Homo sapiens_hsa049721.10360275
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.10121379
59Estrogen signaling pathway_Homo sapiens_hsa049151.07175592
60ABC transporters_Homo sapiens_hsa020101.05136811
61Glioma_Homo sapiens_hsa052141.03981889
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01092254
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99071020
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97542591
65Thyroid hormone synthesis_Homo sapiens_hsa049180.96823279
66Melanogenesis_Homo sapiens_hsa049160.92430142
67Alcoholism_Homo sapiens_hsa050340.91201945
68Vibrio cholerae infection_Homo sapiens_hsa051100.90216662
69Notch signaling pathway_Homo sapiens_hsa043300.90196710
70Hedgehog signaling pathway_Homo sapiens_hsa043400.85781389
71Circadian rhythm_Homo sapiens_hsa047100.83178154
72Collecting duct acid secretion_Homo sapiens_hsa049660.81057272
73Glucagon signaling pathway_Homo sapiens_hsa049220.78474182
74Nitrogen metabolism_Homo sapiens_hsa009100.78161827
75Dorso-ventral axis formation_Homo sapiens_hsa043200.77819321
76Arachidonic acid metabolism_Homo sapiens_hsa005900.77809716
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.77372680
78ErbB signaling pathway_Homo sapiens_hsa040120.77230317
79Phototransduction_Homo sapiens_hsa047440.75182751
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74013016
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73693272
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73132922
83Basal cell carcinoma_Homo sapiens_hsa052170.71817705
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71444146
85Dilated cardiomyopathy_Homo sapiens_hsa054140.70251322
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65557400
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64811400
88Starch and sucrose metabolism_Homo sapiens_hsa005000.62159044
89Rap1 signaling pathway_Homo sapiens_hsa040150.61377078
90Choline metabolism in cancer_Homo sapiens_hsa052310.61157293
91mTOR signaling pathway_Homo sapiens_hsa041500.61031250
92Non-small cell lung cancer_Homo sapiens_hsa052230.60894132
93MAPK signaling pathway_Homo sapiens_hsa040100.60074465
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59616332
95Oocyte meiosis_Homo sapiens_hsa041140.57380209
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57239712
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.57101409
98Chemokine signaling pathway_Homo sapiens_hsa040620.57015674
99Axon guidance_Homo sapiens_hsa043600.56282604
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.56162258
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55625633
102Steroid biosynthesis_Homo sapiens_hsa001000.53968980
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53768125
104Sulfur metabolism_Homo sapiens_hsa009200.52757421
105Ras signaling pathway_Homo sapiens_hsa040140.52173456
106Prion diseases_Homo sapiens_hsa050200.51852397
107Ovarian steroidogenesis_Homo sapiens_hsa049130.51720322
108Hepatitis C_Homo sapiens_hsa051600.51404207
109Adherens junction_Homo sapiens_hsa045200.51159218
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.50435021
111PPAR signaling pathway_Homo sapiens_hsa033200.49503714
112Inositol phosphate metabolism_Homo sapiens_hsa005620.48396668
113Hippo signaling pathway_Homo sapiens_hsa043900.47419978
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44749235
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44412463
116VEGF signaling pathway_Homo sapiens_hsa043700.44297731
117Cardiac muscle contraction_Homo sapiens_hsa042600.42923954
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.40934528
119Endocytosis_Homo sapiens_hsa041440.40424967
120Insulin signaling pathway_Homo sapiens_hsa049100.40398925
121Insulin resistance_Homo sapiens_hsa049310.40282986
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40267772
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39890091
124Prolactin signaling pathway_Homo sapiens_hsa049170.39343954
125Butanoate metabolism_Homo sapiens_hsa006500.38825622
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37773001
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35733053
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35527077
129Lysosome_Homo sapiens_hsa041420.34848660
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34634101
131Endometrial cancer_Homo sapiens_hsa052130.34030929
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.33646525
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33371737
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33346142
135Arginine and proline metabolism_Homo sapiens_hsa003300.32981122
136African trypanosomiasis_Homo sapiens_hsa051430.32807470
137Bile secretion_Homo sapiens_hsa049760.32358236
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30831626
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30217642
140Wnt signaling pathway_Homo sapiens_hsa043100.27332239
141Renal cell carcinoma_Homo sapiens_hsa052110.27117069
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.26648558
143Metabolic pathways_Homo sapiens_hsa011000.25564107
144Primary bile acid biosynthesis_Homo sapiens_hsa001200.24955234
145Glycerolipid metabolism_Homo sapiens_hsa005610.16805214
146Fatty acid biosynthesis_Homo sapiens_hsa000610.16426488
147Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15534053

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