LRRC14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.51971205
2DNA deamination (GO:0045006)8.36751256
3transcription from mitochondrial promoter (GO:0006390)7.34515352
4proline metabolic process (GO:0006560)6.94346797
5replication fork processing (GO:0031297)6.19999765
6oxidative demethylation (GO:0070989)6.12023706
7embryonic process involved in female pregnancy (GO:0060136)5.70771105
8DNA strand renaturation (GO:0000733)5.57927673
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.54152930
10positive regulation of protein homooligomerization (GO:0032464)5.40502223
11pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.15008527
12regulation of protein homooligomerization (GO:0032462)4.96146638
13viral mRNA export from host cell nucleus (GO:0046784)4.86872404
14spliceosomal tri-snRNP complex assembly (GO:0000244)4.86324287
15mitochondrial DNA metabolic process (GO:0032042)4.84300085
16negative regulation of JAK-STAT cascade (GO:0046426)4.74714316
17establishment of apical/basal cell polarity (GO:0035089)4.71638615
18negative regulation of cell size (GO:0045792)4.61055613
19telomere maintenance via semi-conservative replication (GO:0032201)4.53637625
20regulation of integrin activation (GO:0033623)4.52794820
21base-excision repair (GO:0006284)4.49997277
22base-excision repair, AP site formation (GO:0006285)4.49344646
23negative regulation of erythrocyte differentiation (GO:0045647)4.48547039
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.45927053
25DNA integration (GO:0015074)4.43578256
26pyrimidine nucleotide catabolic process (GO:0006244)4.40294635
27mitochondrial RNA metabolic process (GO:0000959)4.40147568
28negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.37622345
29mannose metabolic process (GO:0006013)4.35489425
30somatic hypermutation of immunoglobulin genes (GO:0016446)4.34603482
31somatic diversification of immune receptors via somatic mutation (GO:0002566)4.34603482
32regulation of mammary gland epithelial cell proliferation (GO:0033599)4.31293021
33negative regulation of cell cycle arrest (GO:0071157)4.28174672
34establishment or maintenance of monopolar cell polarity (GO:0061339)4.19978492
35establishment of monopolar cell polarity (GO:0061162)4.19978492
36poly(A)+ mRNA export from nucleus (GO:0016973)4.17425968
37mitotic G1 DNA damage checkpoint (GO:0031571)4.02587225
38DNA strand elongation involved in DNA replication (GO:0006271)4.02565178
39protein retention in ER lumen (GO:0006621)4.02522219
40mRNA cleavage (GO:0006379)3.94336129
41apoptotic process involved in morphogenesis (GO:0060561)3.93409428
42maturation of 5.8S rRNA (GO:0000460)3.89127973
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.88921860
44DNA strand elongation (GO:0022616)3.87335991
45regulation of translational fidelity (GO:0006450)3.80838993
46cellular response to ATP (GO:0071318)3.79341784
47Golgi transport vesicle coating (GO:0048200)3.76223167
48COPI coating of Golgi vesicle (GO:0048205)3.76223167
49histone H4-K12 acetylation (GO:0043983)3.75629411
50formation of translation preinitiation complex (GO:0001731)3.74856247
51double-strand break repair via nonhomologous end joining (GO:0006303)3.74068393
52non-recombinational repair (GO:0000726)3.74068393
53glial cell migration (GO:0008347)3.72139826
54peptidyl-arginine omega-N-methylation (GO:0035247)3.70453298
55negative regulation of mRNA processing (GO:0050686)3.65744150
56snRNA metabolic process (GO:0016073)3.64674771
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.62910870
58mitotic chromosome condensation (GO:0007076)3.60813946
59DNA ligation (GO:0006266)3.60366447
60G1 DNA damage checkpoint (GO:0044783)3.55083625
61intracellular estrogen receptor signaling pathway (GO:0030520)3.54906937
62dosage compensation (GO:0007549)3.53271770
63negative regulation of RNA splicing (GO:0033119)3.50500596
64focal adhesion assembly (GO:0048041)3.47544421
65cell-substrate adherens junction assembly (GO:0007045)3.47544421
66regulation of DNA damage checkpoint (GO:2000001)3.46593846
67folic acid metabolic process (GO:0046655)3.44455972
68telomere maintenance via recombination (GO:0000722)3.43542836
69termination of RNA polymerase II transcription (GO:0006369)3.43378757
70planar cell polarity pathway involved in neural tube closure (GO:0090179)3.42489830
71positive regulation of DNA repair (GO:0045739)3.41185652
72adherens junction assembly (GO:0034333)3.40659942
73kinetochore assembly (GO:0051382)3.39704014
74positive regulation of developmental pigmentation (GO:0048087)3.39015595
75UV protection (GO:0009650)3.38471759
76retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.34563236
77regulation of double-strand break repair via homologous recombination (GO:0010569)3.34417829
78mitotic recombination (GO:0006312)3.33895362
79glutamine family amino acid biosynthetic process (GO:0009084)3.33403708
80DNA double-strand break processing (GO:0000729)3.32622100
81mitotic G1/S transition checkpoint (GO:0044819)3.32558612
82telomere maintenance via telomere lengthening (GO:0010833)3.31499462
83modulation by virus of host process (GO:0019054)3.30613848
84mitotic nuclear envelope reassembly (GO:0007084)3.29566125
85nuclear envelope reassembly (GO:0031468)3.29566125
86regulation of chromatin binding (GO:0035561)3.28111217
87DNA unwinding involved in DNA replication (GO:0006268)3.26542830
88DNA demethylation (GO:0080111)3.26418988
89negative regulation of Ras GTPase activity (GO:0034261)3.25208838
90proteasome assembly (GO:0043248)3.24368971
91regulation of NFAT protein import into nucleus (GO:0051532)3.23919749
92negative regulation of protein oligomerization (GO:0032460)3.22242892
93GDP-mannose metabolic process (GO:0019673)3.22064533
94positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.21290920
95embryonic camera-type eye development (GO:0031076)3.21103401
96semaphorin-plexin signaling pathway (GO:0071526)3.18275928
97protein deneddylation (GO:0000338)3.16465976
98cullin deneddylation (GO:0010388)3.14655597
99snRNA processing (GO:0016180)3.14472932
100phosphatidylglycerol biosynthetic process (GO:0006655)3.13675371
101cellular response to zinc ion (GO:0071294)3.13562059
102pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.13496672
103DNA topological change (GO:0006265)3.13125359
104single strand break repair (GO:0000012)3.12776372
105regulation of mitochondrial depolarization (GO:0051900)3.12490902
106regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.10437505
107face development (GO:0060324)3.08384509
108meiotic chromosome segregation (GO:0045132)3.08199879
109convergent extension (GO:0060026)3.06086211
110synaptic vesicle endocytosis (GO:0048488)3.04377015
111spliceosomal snRNP assembly (GO:0000387)3.03876947
112activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.03654690
113maternal placenta development (GO:0001893)3.03417254
114protein-DNA complex disassembly (GO:0032986)3.02948659
115nucleosome disassembly (GO:0006337)3.02948659
116histone arginine methylation (GO:0034969)3.01961506
117embryonic placenta development (GO:0001892)3.01862272
118negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99512829
119regulation of cAMP-dependent protein kinase activity (GO:2000479)2.97308584
120modulation by symbiont of host cellular process (GO:0044068)2.97145639
121positive regulation of nuclease activity (GO:0032075)2.96549930
122cellular protein complex localization (GO:0034629)2.95958457
123negative regulation of mRNA metabolic process (GO:1903312)2.95215967
124negative regulation of telomere maintenance (GO:0032205)2.94924094
125resolution of meiotic recombination intermediates (GO:0000712)2.94800850
126negative regulation of viral release from host cell (GO:1902187)2.94103737
127cell migration in hindbrain (GO:0021535)2.90809067
1283-UTR-mediated mRNA stabilization (GO:0070935)2.90798230
129positive regulation by host of viral transcription (GO:0043923)2.88899936
130neuron fate specification (GO:0048665)2.86963787
131mRNA polyadenylation (GO:0006378)2.85935164
132positive regulation of protein oligomerization (GO:0032461)2.85851391
133regulation of protein oligomerization (GO:0032459)2.84623460
134atrioventricular valve morphogenesis (GO:0003181)2.84588872
135peptidyl-arginine methylation (GO:0018216)2.83406863
136peptidyl-arginine N-methylation (GO:0035246)2.83406863
137regulation of glucose import in response to insulin stimulus (GO:2001273)2.82766456
138endothelial cell chemotaxis (GO:0035767)2.82367024
139protein insertion into membrane (GO:0051205)2.82019655
140somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.80607061
141somatic cell DNA recombination (GO:0016444)2.80607061
142regulation of ARF GTPase activity (GO:0032312)2.80193819
143tRNA methylation (GO:0030488)2.79834347
144desmosome organization (GO:0002934)2.79534316
145pseudouridine synthesis (GO:0001522)2.77809729
146activation of Rac GTPase activity (GO:0032863)2.77023382
147protein localization to endosome (GO:0036010)2.76045237
148histone H4 deacetylation (GO:0070933)2.73014059
149positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.71462598
150homocysteine metabolic process (GO:0050667)2.69390914
151positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.68826292
152protein complex localization (GO:0031503)2.68671952
153regulation of nuclease activity (GO:0032069)2.66815137
154cellular response to epidermal growth factor stimulus (GO:0071364)2.66795798
155regulation of histone H3-K27 methylation (GO:0061085)2.64834749
156modulation by virus of host morphology or physiology (GO:0019048)2.64120352
157pentose-phosphate shunt (GO:0006098)2.63846272
158folic acid-containing compound biosynthetic process (GO:0009396)2.62642434
159activation of MAPKKK activity (GO:0000185)2.62393339
160urea cycle (GO:0000050)2.60987045
161glucocorticoid receptor signaling pathway (GO:0042921)2.60895567
162cell-substrate junction assembly (GO:0007044)2.59589143
163negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.59473243
164DNA replication initiation (GO:0006270)2.59094238
165positive regulation of Cdc42 GTPase activity (GO:0043089)2.58430509
166endoplasmic reticulum unfolded protein response (GO:0030968)2.57144532
167negative regulation of necroptotic process (GO:0060546)2.53574198
168DNA duplex unwinding (GO:0032508)2.52817604
169chromosome condensation (GO:0030261)2.51402745
170activation of JUN kinase activity (GO:0007257)2.51097362
171L-serine metabolic process (GO:0006563)2.47783855
172response to muramyl dipeptide (GO:0032495)2.47772004
173thymic T cell selection (GO:0045061)2.47592247
174ribosome biogenesis (GO:0042254)2.47281311
175retrograde transport, endosome to Golgi (GO:0042147)2.46226717
176positive regulation of protein dephosphorylation (GO:0035307)2.45739064
177heterochromatin organization (GO:0070828)2.44815738
178regulation of type I interferon-mediated signaling pathway (GO:0060338)2.42836732
179stress fiber assembly (GO:0043149)2.42511267
180ER-nucleus signaling pathway (GO:0006984)2.41668282
181cytoskeletal anchoring at plasma membrane (GO:0007016)2.41431635
182protein export from nucleus (GO:0006611)2.40937573
183positive regulation of histone deacetylation (GO:0031065)2.38840142
184glucose catabolic process (GO:0006007)2.38393182
185peptidyl-lysine dimethylation (GO:0018027)2.37221174

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.69698201
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.19667123
3ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.03996272
4MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90226361
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80098914
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74610267
7E2F7_22180533_ChIP-Seq_HELA_Human2.74360293
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59829934
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.51352434
10* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.44833759
11* VDR_21846776_ChIP-Seq_THP-1_Human2.41022658
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36505279
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.35274518
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34294432
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.27396008
16YY1_21170310_ChIP-Seq_MESCs_Mouse2.27251278
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.27188443
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27083840
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.26137036
20* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18480569
21RACK7_27058665_Chip-Seq_MCF-7_Human2.12579706
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97078428
23KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.96502482
24CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.96199007
25P68_20966046_ChIP-Seq_HELA_Human1.92421870
26TCF7_22412390_ChIP-Seq_EML_Mouse1.92327304
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.91246973
28* KDM2B_26808549_Chip-Seq_DND41_Human1.90596068
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89470886
30DCP1A_22483619_ChIP-Seq_HELA_Human1.89402587
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.86037812
32* TET1_21451524_ChIP-Seq_MESCs_Mouse1.84197688
33GABP_19822575_ChIP-Seq_HepG2_Human1.83046611
34TTF2_22483619_ChIP-Seq_HELA_Human1.81033871
35* LXR_22292898_ChIP-Seq_THP-1_Human1.80354017
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79163355
37XRN2_22483619_ChIP-Seq_HELA_Human1.78539847
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75575585
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73100059
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.72269942
41PU.1_20513432_ChIP-Seq_Bcells_Mouse1.70784092
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.70403567
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.70403567
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.70403567
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70047379
46MYC_22102868_ChIP-Seq_BL_Human1.69887164
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68521351
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.65239419
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64793039
50SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.63857436
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63320410
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62715716
53* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61295730
54CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.60996649
55MAF_26560356_Chip-Seq_TH2_Human1.59845075
56* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58583506
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58180830
58* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55810748
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53306403
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.53027868
61SMC4_20622854_ChIP-Seq_HELA_Human1.52988455
62KDM2B_26808549_Chip-Seq_K562_Human1.51294950
63MAF_26560356_Chip-Seq_TH1_Human1.48567193
64POU5F1_16518401_ChIP-PET_MESCs_Mouse1.47921009
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.47850455
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46145291
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45483227
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44564706
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43737660
70* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43340559
71* VDR_24763502_ChIP-Seq_THP-1_Human1.43242418
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.43227808
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42727830
74BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.42237925
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42077933
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42039438
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41015783
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40776388
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.39493351
80* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.39208440
81* CREB1_26743006_Chip-Seq_LNCaP_Human1.37818918
82BCOR_27268052_Chip-Seq_Bcells_Human1.35373753
83* UTX_26944678_Chip-Seq_JUKART_Human1.34622611
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34227360
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34196118
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33903961
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.32282220
88* NCOR1_26117541_ChIP-Seq_K562_Human1.30204868
89E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30059926
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29976073
91* KDM2B_26808549_Chip-Seq_JURKAT_Human1.29795928
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29686410
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.29581477
94ETS1_21867929_ChIP-Seq_TH2_Mouse1.29462030
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27959423
96CIITA_25753668_ChIP-Seq_RAJI_Human1.27789556
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27535387
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27456937
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26310484
100VDR_23849224_ChIP-Seq_CD4+_Human1.26019020
101BCL6_27268052_Chip-Seq_Bcells_Human1.25574376
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25458315
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24210922
104FOXP1_21924763_ChIP-Seq_HESCs_Human1.24063486
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24053082
106NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23992169
107TP53_22127205_ChIP-Seq_IMR90_Human1.23324748
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23292007
109POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23111904
110POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22734377
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22253728
112FOXM1_23109430_ChIP-Seq_U2OS_Human1.21333957
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20710399
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.20598641
115* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19395892
116EGR1_19374776_ChIP-ChIP_THP-1_Human1.19273905
117SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.18884876
118TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18682335
119STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18587183
120MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17150637
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17123876
122* ATF3_27146783_Chip-Seq_COLON_Human1.16920779
123SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16849475
124ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16414279
125ZNF263_19887448_ChIP-Seq_K562_Human1.16379343
126CTCF_21964334_Chip-Seq_Bcells_Human1.15308891
127P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14880157
128* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.14526485
129KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14069497
130* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13181639
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13115896
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12874815
133GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12626095
134PHF8_20622854_ChIP-Seq_HELA_Human1.12206388
135FOXP3_21729870_ChIP-Seq_TREG_Human1.12126070
136CTCF_27219007_Chip-Seq_Bcells_Human1.11747448
137RARA_24833708_ChIP-Seq_LIVER_Mouse1.11705938
138E2F1_20622854_ChIP-Seq_HELA_Human1.11692529
139SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11686344
140TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11506910
141CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10820281
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09906698
143SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09857532
144NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09424963
145CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08850278
146RARB_24833708_ChIP-Seq_LIVER_Mouse1.08716051
147* KDM5A_27292631_Chip-Seq_BREAST_Human1.08439139
148TFEB_21752829_ChIP-Seq_HELA_Human1.08202851
149E2F1_21310950_ChIP-Seq_MCF-7_Human1.08129048
150DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08087287
151RUNX1_22412390_ChIP-Seq_EML_Mouse1.07877730
152ESR2_21235772_ChIP-Seq_MCF-7_Human1.07627292
153KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07472947
154CTCF_26484167_Chip-Seq_Bcells_Mouse1.07225177
155TP63_19390658_ChIP-ChIP_HaCaT_Human1.04901177
156ELF1_20517297_ChIP-Seq_JURKAT_Human1.04383310
157STAT1_20625510_ChIP-Seq_HELA_Human1.04138402
158SA1_27219007_Chip-Seq_ERYTHROID_Human1.03019050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.71472078
2MP0008057_abnormal_DNA_replication5.22975677
3MP0010030_abnormal_orbit_morphology4.55667694
4MP0005171_absent_coat_pigmentation3.88066639
5MP0004233_abnormal_muscle_weight3.36262059
6MP0009278_abnormal_bone_marrow3.32217444
7MP0008995_early_reproductive_senescence3.14931500
8MP0004185_abnormal_adipocyte_glucose2.94911175
9MP0005451_abnormal_body_composition2.92154666
10MP0003786_premature_aging2.74110856
11MP0005058_abnormal_lysosome_morphology2.71797524
12MP0010094_abnormal_chromosome_stability2.66928599
13MP0005174_abnormal_tail_pigmentation2.60981214
14MP0001849_ear_inflammation2.60125509
15MP0008260_abnormal_autophagy2.59846017
16MP0008058_abnormal_DNA_repair2.47627707
17MP0001545_abnormal_hematopoietic_system2.33549030
18MP0005397_hematopoietic_system_phenotyp2.33549030
19MP0000015_abnormal_ear_pigmentation2.31115770
20MP0002009_preneoplasia2.30612361
21MP0002653_abnormal_ependyma_morphology2.21935741
22MP0003111_abnormal_nucleus_morphology2.19716296
23MP0004133_heterotaxia2.13041361
24MP0003890_abnormal_embryonic-extraembry2.09920256
25MP0000003_abnormal_adipose_tissue2.05443321
26MP0002102_abnormal_ear_morphology2.03006946
27MP0003119_abnormal_digestive_system2.00106194
28MP0006072_abnormal_retinal_apoptosis1.99653164
29MP0001348_abnormal_lacrimal_gland1.97253149
30MP0003283_abnormal_digestive_organ1.96657870
31MP0004858_abnormal_nervous_system1.94280620
32MP0005645_abnormal_hypothalamus_physiol1.94267137
33MP0002249_abnormal_larynx_morphology1.92393620
34MP0008877_abnormal_DNA_methylation1.91813803
35MP0005075_abnormal_melanosome_morpholog1.89368781
36MP0004957_abnormal_blastocyst_morpholog1.86833532
37MP0008932_abnormal_embryonic_tissue1.85613025
38MP0003172_abnormal_lysosome_physiology1.83389663
39MP0000678_abnormal_parathyroid_gland1.82705519
40MP0004142_abnormal_muscle_tone1.79660203
41MP0000751_myopathy1.74731357
42MP0005501_abnormal_skin_physiology1.72232335
43MP0001661_extended_life_span1.69614645
44MP0005666_abnormal_adipose_tissue1.61097327
45MP0003566_abnormal_cell_adhesion1.60487012
46MP0003763_abnormal_thymus_physiology1.57328016
47MP0002877_abnormal_melanocyte_morpholog1.48788136
48MP0002796_impaired_skin_barrier1.44600151
49MP0005375_adipose_tissue_phenotype1.43197506
50MP0005409_darkened_coat_color1.39972684
51MP0000733_abnormal_muscle_development1.39412323
52MP0000462_abnormal_digestive_system1.38369447
53MP0000747_muscle_weakness1.37330108
54MP0003693_abnormal_embryo_hatching1.34936423
55MP0000490_abnormal_crypts_of1.34814396
56MP0009333_abnormal_splenocyte_physiolog1.31993443
57MP0000371_diluted_coat_color1.31568990
58MP0002282_abnormal_trachea_morphology1.29403110
59MP0009840_abnormal_foam_cell1.28246720
60MP0003091_abnormal_cell_migration1.26787452
61MP0006292_abnormal_olfactory_placode1.26273596
62MP0002089_abnormal_postnatal_growth/wei1.25687408
63MP0001529_abnormal_vocalization1.25494880
64MP0003077_abnormal_cell_cycle1.24595921
65MP0003436_decreased_susceptibility_to1.24114776
66MP0002084_abnormal_developmental_patter1.22808950
67MP0010234_abnormal_vibrissa_follicle1.22569513
68MP0004381_abnormal_hair_follicle1.22239082
69MP0003183_abnormal_peptide_metabolism1.22134468
70MP0000858_altered_metastatic_potential1.20178478
71MP0005623_abnormal_meninges_morphology1.19165918
72MP0004947_skin_inflammation1.18840416
73MP0005621_abnormal_cell_physiology1.18797701
74MP0002085_abnormal_embryonic_tissue1.18572856
75MP0000013_abnormal_adipose_tissue1.17871980
76MP0002751_abnormal_autonomic_nervous1.14750949
77MP0003191_abnormal_cellular_cholesterol1.13956311
78MP0003303_peritoneal_inflammation1.13886977
79MP0001697_abnormal_embryo_size1.13738970
80MP0005083_abnormal_biliary_tract1.12911771
81MP0002932_abnormal_joint_morphology1.12114533
82MP0002060_abnormal_skin_morphology1.11673349
83MP0003718_maternal_effect1.11547626
84MP0000537_abnormal_urethra_morphology1.10454391
85MP0003656_abnormal_erythrocyte_physiolo1.09476890
86MP0001293_anophthalmia1.09170210
87MP0004808_abnormal_hematopoietic_stem1.09034190
88MP0009931_abnormal_skin_appearance1.08713074
89MP0001346_abnormal_lacrimal_gland1.07960618
90MP0005257_abnormal_intraocular_pressure1.07456012
91MP0001873_stomach_inflammation1.06840513
92MP0009672_abnormal_birth_weight1.05617559
93MP0001502_abnormal_circadian_rhythm1.04607716
94MP0003137_abnormal_impulse_conducting1.04056907
95MP0006276_abnormal_autonomic_nervous1.02984084
96MP0005670_abnormal_white_adipose1.02649967
97MP0002638_abnormal_pupillary_reflex1.02105508
98MP0000579_abnormal_nail_morphology1.02065802
99MP0002111_abnormal_tail_morphology1.00190646
100MP0005076_abnormal_cell_differentiation0.99213027
101MP0000049_abnormal_middle_ear0.99086501
102MP0004197_abnormal_fetal_growth/weight/0.98981492
103MP0000759_abnormal_skeletal_muscle0.97297921
104MP0000750_abnormal_muscle_regeneration0.97227626
105MP0000703_abnormal_thymus_morphology0.96605286
106MP0002114_abnormal_axial_skeleton0.96585828
107MP0002086_abnormal_extraembryonic_tissu0.96282456
108MP0002733_abnormal_thermal_nociception0.96144857
109MP0002269_muscular_atrophy0.95312375
110MP0002075_abnormal_coat/hair_pigmentati0.94108742
111MP0002970_abnormal_white_adipose0.93628415
112MP0000470_abnormal_stomach_morphology0.93201044
113MP0001186_pigmentation_phenotype0.92468018
114MP0003279_aneurysm0.92217042
115MP0002938_white_spotting0.90017195
116MP0000639_abnormal_adrenal_gland0.89568982
117MP0000681_abnormal_thyroid_gland0.88465107
118MP0008438_abnormal_cutaneous_collagen0.88344674
119MP0001340_abnormal_eyelid_morphology0.88047427
120MP0000955_abnormal_spinal_cord0.86885167
121MP0005253_abnormal_eye_physiology0.86456068
122MP0005380_embryogenesis_phenotype0.86258157
123MP0001672_abnormal_embryogenesis/_devel0.86258157
124MP0000350_abnormal_cell_proliferation0.84640981
125MP0000516_abnormal_urinary_system0.84306696
126MP0005367_renal/urinary_system_phenotyp0.84306696
127MP0001145_abnormal_male_reproductive0.84258332
128MP0005384_cellular_phenotype0.82418729
129MP0001216_abnormal_epidermal_layer0.79989698
130MP0003984_embryonic_growth_retardation0.79969683
131MP0002116_abnormal_craniofacial_bone0.79083677
132MP0002398_abnormal_bone_marrow0.78575040
133MP0002019_abnormal_tumor_incidence0.78368586
134MP0003935_abnormal_craniofacial_develop0.78267056
135MP0001324_abnormal_eye_pigmentation0.77721669
136MP0000313_abnormal_cell_death0.77063147
137MP0002210_abnormal_sex_determination0.76904655
138MP0002396_abnormal_hematopoietic_system0.76731581
139MP0000778_abnormal_nervous_system0.76668301
140MP0002080_prenatal_lethality0.76659381
141MP0005330_cardiomyopathy0.76508216
142MP0010630_abnormal_cardiac_muscle0.76166380
143MP0003453_abnormal_keratinocyte_physiol0.75725181
144MP0001730_embryonic_growth_arrest0.74719860
145MP0003385_abnormal_body_wall0.72297446
146MP0002184_abnormal_innervation0.71933447
147MP0008007_abnormal_cellular_replicative0.71865155
148MP0003567_abnormal_fetal_cardiomyocyte0.71686378
149MP0002088_abnormal_embryonic_growth/wei0.71635802
150MP0003329_amyloid_beta_deposits0.71584617
151MP0010771_integument_phenotype0.71319402
152MP0009384_cardiac_valve_regurgitation0.71252500
153MP0003755_abnormal_palate_morphology0.70265769
154MP0003861_abnormal_nervous_system0.68784141
155MP0005023_abnormal_wound_healing0.68774348
156MP0001929_abnormal_gametogenesis0.68050470
157MP0001958_emphysema0.67032593
158MP0004087_abnormal_muscle_fiber0.66880921
159MP0004130_abnormal_muscle_cell0.66844211
160MP0001970_abnormal_pain_threshold0.65853471
161MP0009115_abnormal_fat_cell0.64999850
162MP0000653_abnormal_sex_gland0.64009879
163MP0000762_abnormal_tongue_morphology0.63638112
164MP0003938_abnormal_ear_development0.63260680
165MP0003122_maternal_imprinting0.63125793
166MP0001919_abnormal_reproductive_system0.63115687
167MP0008770_decreased_survivor_rate0.61075009

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.40214708
2Tongue fasciculations (HP:0001308)4.91045212
3Poikiloderma (HP:0001029)4.65981654
4Rib fusion (HP:0000902)4.51365631
5Muscle fibrillation (HP:0010546)4.38536883
6Facial hemangioma (HP:0000329)4.33313758
7Increased IgM level (HP:0003496)4.30731718
8Abnormality of the aortic arch (HP:0012303)4.14523058
9Annular pancreas (HP:0001734)4.05244353
10Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.82711919
11Turricephaly (HP:0000262)3.82034132
12Failure to thrive in infancy (HP:0001531)3.80914829
13Hyperacusis (HP:0010780)3.71276757
14Albinism (HP:0001022)3.48706392
15Rectal fistula (HP:0100590)3.43028551
16Rectovaginal fistula (HP:0000143)3.43028551
17Pustule (HP:0200039)3.39993622
18Broad face (HP:0000283)3.39485833
19Orthostatic hypotension (HP:0001278)3.31902245
20Coronal craniosynostosis (HP:0004440)3.22549769
21Absent thumb (HP:0009777)3.21760807
22Intestinal atresia (HP:0011100)3.16210629
23Absent radius (HP:0003974)3.14311761
24Narrow nasal bridge (HP:0000446)3.10050630
25Thin bony cortex (HP:0002753)3.09717733
26Broad alveolar ridges (HP:0000187)3.07822041
27Dysautonomia (HP:0002459)3.04458049
28Abnormality of male internal genitalia (HP:0000022)3.04065495
29Myopathic facies (HP:0002058)3.01994041
30Aplasia involving forearm bones (HP:0009822)3.01419334
31Absent forearm bone (HP:0003953)3.01419334
32Vaginal fistula (HP:0004320)3.00144099
33Abnormality of polysaccharide metabolism (HP:0011012)2.95913399
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.95913399
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.95913399
36Alopecia of scalp (HP:0002293)2.94122775
37Intestinal fistula (HP:0100819)2.93644332
38Degeneration of anterior horn cells (HP:0002398)2.93275307
39Abnormality of the anterior horn cell (HP:0006802)2.93275307
40Patellar aplasia (HP:0006443)2.89434640
41Biconcave vertebral bodies (HP:0004586)2.87686490
42Mucopolysacchariduria (HP:0008155)2.84968883
43Urinary glycosaminoglycan excretion (HP:0003541)2.84968883
44Progressive muscle weakness (HP:0003323)2.76093088
45Ulnar bowing (HP:0003031)2.76020214
46Long palpebral fissure (HP:0000637)2.75967485
47Aplasia/hypoplasia of the humerus (HP:0006507)2.74007032
48Aplasia/Hypoplasia of the patella (HP:0006498)2.73255299
49Alacrima (HP:0000522)2.72453475
50Obstructive sleep apnea (HP:0002870)2.70919669
51Squamous cell carcinoma (HP:0002860)2.70357462
52Male infertility (HP:0003251)2.69767346
53Anteriorly placed anus (HP:0001545)2.68424750
54Insomnia (HP:0100785)2.64857049
55Broad distal phalanx of finger (HP:0009836)2.62909602
56Basal cell carcinoma (HP:0002671)2.62494760
57Acute lymphatic leukemia (HP:0006721)2.62408110
58Short humerus (HP:0005792)2.62277426
59Dysostosis multiplex (HP:0000943)2.61997344
60Congenital hip dislocation (HP:0001374)2.61533454
61Growth hormone excess (HP:0000845)2.61381568
62Distal lower limb amyotrophy (HP:0008944)2.61285781
63Ragged-red muscle fibers (HP:0003200)2.60940179
64Bifid uvula (HP:0000193)2.59788073
65Disproportionate tall stature (HP:0001519)2.58925178
66Aplasia of the musculature (HP:0100854)2.57658266
67Short chin (HP:0000331)2.56458116
68Large for gestational age (HP:0001520)2.55824363
69Distal upper limb amyotrophy (HP:0007149)2.55548966
70Upper limb amyotrophy (HP:0009129)2.55548966
71Tented upper lip vermilion (HP:0010804)2.55287204
72Colitis (HP:0002583)2.53418675
73Testicular atrophy (HP:0000029)2.53028791
74Joint stiffness (HP:0001387)2.52860024
75Premature graying of hair (HP:0002216)2.52761325
76Hemorrhage of the eye (HP:0011885)2.50206520
77Selective tooth agenesis (HP:0001592)2.49123900
78Abnormality of the ileum (HP:0001549)2.48371504
79Exertional dyspnea (HP:0002875)2.44578917
80Thin ribs (HP:0000883)2.42781105
81Abnormal hemoglobin (HP:0011902)2.42480281
82Hypochromic microcytic anemia (HP:0004840)2.37372436
83Capillary hemangiomas (HP:0005306)2.37147861
84Hypertensive crisis (HP:0100735)2.31764661
85Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.31024408
86Vertebral hypoplasia (HP:0008417)2.31024408
87Hypotelorism (HP:0000601)2.30430022
88Stridor (HP:0010307)2.29201799
89Abnormal respiratory motile cilium morphology (HP:0005938)2.28208291
90Abnormal respiratory epithelium morphology (HP:0012253)2.28208291
91Cervical subluxation (HP:0003308)2.26206348
92Reticulocytosis (HP:0001923)2.21724653
93Cellulitis (HP:0100658)2.19939414
94Small hand (HP:0200055)2.19227762
95Vertebral compression fractures (HP:0002953)2.18161039
96Abnormality of the fingertips (HP:0001211)2.18106539
97Abnormal number of incisors (HP:0011064)2.17749895
98Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17652883
99Progressive external ophthalmoplegia (HP:0000590)2.16923457
100Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16833127
101Increased connective tissue (HP:0009025)2.15111563
102Decreased lacrimation (HP:0000633)2.14379622
103Difficulty climbing stairs (HP:0003551)2.12806775
104Pancreatic islet-cell hyperplasia (HP:0004510)2.12434564
105Abnormality of the thoracic spine (HP:0100711)2.10870996
106Pointed chin (HP:0000307)2.10194805
107Achilles tendon contracture (HP:0001771)2.09826816
108Abnormal number of erythroid precursors (HP:0012131)2.08588012
109Easy fatigability (HP:0003388)2.05943966
110Abnormality of the labia minora (HP:0012880)2.05232461
111Hypokinesia (HP:0002375)2.04816386
112J-shaped sella turcica (HP:0002680)2.03712852
113Diaphragmatic weakness (HP:0009113)2.03535874
114Flat acetabular roof (HP:0003180)2.03143843
115Abnormality of the umbilical cord (HP:0010881)2.01981695
116Protrusio acetabuli (HP:0003179)2.01788060
117Chromsome breakage (HP:0040012)2.01759831
118Redundant skin (HP:0001582)2.01125927
119Poor suck (HP:0002033)2.01106347
120Premature rupture of membranes (HP:0001788)1.99625992
121Fragile skin (HP:0001030)1.98047498
122Choanal stenosis (HP:0000452)1.97775556
123Hypoplasia of the radius (HP:0002984)1.97719154
124Median cleft lip (HP:0000161)1.97617349
125Hypotrichosis (HP:0001006)1.95834446
126Progressive sensorineural hearing impairment (HP:0000408)1.94741182
127Hypercortisolism (HP:0001578)1.94359451
128Fetal akinesia sequence (HP:0001989)1.92975417
129Reticulocytopenia (HP:0001896)1.92243627
130Flattened epiphyses (HP:0003071)1.92076074
131Muscle fiber atrophy (HP:0100295)1.91257326
132Premature skin wrinkling (HP:0100678)1.89363554
133Mitral regurgitation (HP:0001653)1.87315602
134Shallow orbits (HP:0000586)1.87313704
135Truncus arteriosus (HP:0001660)1.86420447
136Distal lower limb muscle weakness (HP:0009053)1.86357002
137Vertebral fusion (HP:0002948)1.84271246
138Centrally nucleated skeletal muscle fibers (HP:0003687)1.83767338
139Bowed forearm bones (HP:0003956)1.83765322
140Bowing of the arm (HP:0006488)1.83765322
141Febrile seizures (HP:0002373)1.83475634
142Abnormality of cells of the erythroid lineage (HP:0012130)1.83456967
143Bowel incontinence (HP:0002607)1.83231808
144Increased number of teeth (HP:0011069)1.83091609
145Lower limb amyotrophy (HP:0007210)1.82236803
146Hamartoma (HP:0010566)1.81937524
147Abnormal umbilical cord blood vessels (HP:0011403)1.81767681
148Single umbilical artery (HP:0001195)1.81767681
149Abnormality of the fetal cardiovascular system (HP:0010948)1.81767681
150Type 2 muscle fiber atrophy (HP:0003554)1.81617742
151Gastrointestinal inflammation (HP:0004386)1.81003733
152Abnormality of the tricuspid valve (HP:0001702)1.80795432
153Generalized amyotrophy (HP:0003700)1.80418264
154Short thumb (HP:0009778)1.80310591
155Cerebral aneurysm (HP:0004944)1.80107488
156Microvesicular hepatic steatosis (HP:0001414)1.79639730
157Flared metaphyses (HP:0003015)1.79608119
158Metaphyseal cupping (HP:0003021)1.79205580
159Spinal cord lesions (HP:0100561)1.78052789
160Syringomyelia (HP:0003396)1.78052789
161Gastrointestinal dysmotility (HP:0002579)1.77574365
162Abnormality of the distal phalanges of the toes (HP:0010182)1.76617080
163Ankle clonus (HP:0011448)1.75399646
164Abnormality of the Achilles tendon (HP:0005109)1.74109517
165Abnormal large intestine physiology (HP:0012700)1.74090114
166Hand muscle atrophy (HP:0009130)1.73081925
167Breast hypoplasia (HP:0003187)1.69949720
168Patellar dislocation (HP:0002999)1.69476735
169Sparse lateral eyebrow (HP:0005338)1.68172551
170Cholecystitis (HP:0001082)1.68018731
171Abnormal gallbladder physiology (HP:0012438)1.68018731
172Abnormality of reticulocytes (HP:0004312)1.67852292
173Thoracic kyphosis (HP:0002942)1.67557678
174Atelectasis (HP:0100750)1.67189677
175Seborrheic dermatitis (HP:0001051)1.66219904
176Hypoparathyroidism (HP:0000829)1.65934358
177Mildly elevated creatine phosphokinase (HP:0008180)1.64816057
178Blue sclerae (HP:0000592)1.62841109
179Long eyelashes (HP:0000527)1.62589713
180Trismus (HP:0000211)1.62376019
181Exercise-induced myalgia (HP:0003738)1.61829841
182Delayed epiphyseal ossification (HP:0002663)1.61309735
183Ankyloglossia (HP:0010296)1.60194185
184Hyperthyroidism (HP:0000836)1.59748585
185Short nail (HP:0001799)1.59488578
186Abnormality of the distal phalanx of the thumb (HP:0009617)1.59023047
187Elevated alkaline phosphatase (HP:0003155)1.58554492
188Neuronal loss in central nervous system (HP:0002529)1.57521952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.56802282
2DDR24.80173595
3MAPK154.48043960
4MAP3K64.24996969
5SMG13.76449032
6MAP3K113.75882210
7ERN13.17812811
8SIK13.07682040
9MATK3.03007659
10UHMK12.84856816
11PINK12.73523155
12PIM22.69278973
13TYRO32.64167494
14IRAK32.56829506
15EEF2K2.50201837
16FGR2.44933998
17DAPK12.33643271
18MAP2K32.25586249
19CDK122.20776186
20PDGFRA2.12552635
21YES12.06600318
22PRKD22.04367879
23CDK71.91239974
24EPHA21.84249072
25PKN21.83737848
26MST1R1.81139784
27DYRK1B1.78345246
28TLK11.77142844
29BMX1.72314145
30LATS21.71172684
31MAP3K91.67018665
32DYRK31.61812953
33CSK1.55341665
34RIPK11.53579662
35TTN1.48429049
36EIF2AK11.44074394
37TESK21.37893026
38MAP4K11.34681952
39TAOK21.23402576
40CHEK21.19386373
41SIK31.17816895
42MAP3K31.16902211
43PRKD31.14952046
44TESK11.12996366
45PRPF4B1.11856210
46PHKG21.11751166
47PHKG11.11751166
48MARK21.08319903
49PAK41.07852271
50FGFR41.07766356
51IRAK21.05483027
52PLK11.05201012
53RPS6KL11.05073436
54RPS6KC11.05073436
55ARAF1.02718421
56PTK61.00767591
57PIM11.00590395
58CDK40.99659683
59CDK60.94178789
60VRK10.93590878
61TNK20.91726977
62HIPK20.91059932
63RPS6KB20.91058901
64AURKA0.89869517
65MAPK110.88728617
66RPS6KA60.88380548
67STK160.85954723
68ATR0.85210995
69TRPM70.85135048
70CDC42BPA0.83949160
71NTRK10.82691336
72KSR20.82264336
73DYRK20.82191190
74GRK60.82059308
75CDK90.81918753
76RPS6KA20.81917728
77PDPK10.77287148
78MAP3K130.75734584
79MAP3K10.74619127
80MET0.74270621
81TBK10.73851294
82CDK80.70748053
83MAP3K80.68930124
84NME20.68334350
85LMTK20.67757924
86SRPK10.65544339
87CAMKK10.64073318
88BUB10.62876005
89SCYL20.61270215
90JAK30.60940729
91MAPK120.60001165
92GSK3A0.59225522
93LRRK20.58934264
94IRAK40.57904879
95RAF10.56983474
96ZAP700.53324745
97MAP2K20.53120556
98VRK20.52859372
99LYN0.52220918
100BRSK10.52108879
101CSNK2A10.51925440
102RPS6KA10.50673339
103BRAF0.50028480
104TRIB30.49687238
105PRKCI0.47963008
106CDC70.47471677
107CDK180.45794414
108SIK20.45536470
109NEK20.45333947
110CDK20.43914332
111MAP3K70.43417675
112EPHB10.43228245
113CSNK1G10.42915495
114FLT30.42881379
115NTRK20.42207693
116CSNK2A20.42169190
117PRKAA10.42065813
118CDK11A0.41804785
119CAMK2B0.41061277
120CDK150.40833874
121CAMK2G0.37580763
122PAK60.35897352
123MKNK20.34746095
124MTOR0.33976411
125BCKDK0.33867892
126MAPK80.33767286
127ILK0.33507904
128MAPK30.33033538
129TYK20.32850128
130AKT30.32775361
131KSR10.32712781
132RET0.32679272
133PDK10.31490002
134KDR0.30574405
135BRD40.30387642
136CDK140.29953675
137CDK190.29898116
138TAOK10.29594888
139MAP3K100.29289636
140WEE10.27593975
141MKNK10.26177157
142MAPKAPK20.25458355
143PAK10.25324560
144ATM0.24949678
145CDK10.24927657
146MAPKAPK30.24707718
147CAMK2A0.24125073
148MAPK10.24054857
149EGFR0.22041276
150RPS6KB10.21632145
151MAPK140.21535595
152MINK10.21400517
153PTK20.20368133
154CHEK10.20054291
155AURKB0.19483486
156CSNK1G30.18988137
157AKT20.18826406
158CAMK2D0.18334170
159MAPK40.18192812

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034105.04228648
2Mismatch repair_Homo sapiens_hsa034304.63480252
3DNA replication_Homo sapiens_hsa030304.36374982
4Fatty acid biosynthesis_Homo sapiens_hsa000613.61636838
5Nucleotide excision repair_Homo sapiens_hsa034203.21182238
6Other glycan degradation_Homo sapiens_hsa005112.90113448
7Fanconi anemia pathway_Homo sapiens_hsa034602.85168236
8Homologous recombination_Homo sapiens_hsa034402.72635744
9Spliceosome_Homo sapiens_hsa030402.68401336
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38450238
11Ribosome_Homo sapiens_hsa030102.22373698
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.20006007
13Sulfur relay system_Homo sapiens_hsa041222.12835036
14RNA transport_Homo sapiens_hsa030132.12723232
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.04884427
16Non-small cell lung cancer_Homo sapiens_hsa052231.83364514
17mRNA surveillance pathway_Homo sapiens_hsa030151.81061414
18RNA polymerase_Homo sapiens_hsa030201.80211279
19Cell cycle_Homo sapiens_hsa041101.78338895
20Proteasome_Homo sapiens_hsa030501.67620306
21p53 signaling pathway_Homo sapiens_hsa041151.63133894
22Hedgehog signaling pathway_Homo sapiens_hsa043401.60386428
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55287996
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.53853674
25Hippo signaling pathway_Homo sapiens_hsa043901.47534088
26Circadian rhythm_Homo sapiens_hsa047101.46073010
27Pancreatic cancer_Homo sapiens_hsa052121.44966486
28Pentose phosphate pathway_Homo sapiens_hsa000301.44087515
29B cell receptor signaling pathway_Homo sapiens_hsa046621.37778906
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28542214
31Shigellosis_Homo sapiens_hsa051311.27621592
32Basal cell carcinoma_Homo sapiens_hsa052171.26346403
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.26201363
34Notch signaling pathway_Homo sapiens_hsa043301.25926355
35Oocyte meiosis_Homo sapiens_hsa041141.23956582
36Arginine and proline metabolism_Homo sapiens_hsa003301.23709924
37Wnt signaling pathway_Homo sapiens_hsa043101.21863404
38Pyrimidine metabolism_Homo sapiens_hsa002401.20873641
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19240729
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18370094
41Glioma_Homo sapiens_hsa052141.18099782
42mTOR signaling pathway_Homo sapiens_hsa041501.17047292
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.16338528
44Endometrial cancer_Homo sapiens_hsa052131.14389757
45Folate biosynthesis_Homo sapiens_hsa007901.13145362
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04447716
47Prion diseases_Homo sapiens_hsa050201.03819127
48Bladder cancer_Homo sapiens_hsa052191.03450501
49Small cell lung cancer_Homo sapiens_hsa052221.01769552
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97258817
51Inositol phosphate metabolism_Homo sapiens_hsa005620.97009364
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96686092
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96346118
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94726613
55Vitamin B6 metabolism_Homo sapiens_hsa007500.94664707
56Basal transcription factors_Homo sapiens_hsa030220.93680585
57AMPK signaling pathway_Homo sapiens_hsa041520.91783110
58RNA degradation_Homo sapiens_hsa030180.90981069
59Arginine biosynthesis_Homo sapiens_hsa002200.90977662
60Biosynthesis of amino acids_Homo sapiens_hsa012300.89325208
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89131476
62Apoptosis_Homo sapiens_hsa042100.87814966
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86584384
64VEGF signaling pathway_Homo sapiens_hsa043700.86286693
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84145464
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.83044380
67Carbon metabolism_Homo sapiens_hsa012000.82961141
68Vibrio cholerae infection_Homo sapiens_hsa051100.81182023
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.80230283
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79422616
71TGF-beta signaling pathway_Homo sapiens_hsa043500.78385882
72Endocytosis_Homo sapiens_hsa041440.78163560
73N-Glycan biosynthesis_Homo sapiens_hsa005100.77913513
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76211434
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73368989
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72287496
77Hepatitis C_Homo sapiens_hsa051600.70584966
78Gap junction_Homo sapiens_hsa045400.70318861
79Renal cell carcinoma_Homo sapiens_hsa052110.70157129
80Colorectal cancer_Homo sapiens_hsa052100.67938278
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67696896
82Adherens junction_Homo sapiens_hsa045200.66564988
83Prostate cancer_Homo sapiens_hsa052150.66190426
84Prolactin signaling pathway_Homo sapiens_hsa049170.65335718
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.64418597
86Lysosome_Homo sapiens_hsa041420.62880183
87Huntingtons disease_Homo sapiens_hsa050160.62343422
88Epstein-Barr virus infection_Homo sapiens_hsa051690.61576635
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58384879
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58044963
91Focal adhesion_Homo sapiens_hsa045100.57209188
92Parkinsons disease_Homo sapiens_hsa050120.57101539
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.56196271
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55399179
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54764147
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54094532
97Estrogen signaling pathway_Homo sapiens_hsa049150.53990719
98Osteoclast differentiation_Homo sapiens_hsa043800.52410127
99Insulin resistance_Homo sapiens_hsa049310.51912287
100Primary immunodeficiency_Homo sapiens_hsa053400.51726552
101Proteoglycans in cancer_Homo sapiens_hsa052050.51646203
102One carbon pool by folate_Homo sapiens_hsa006700.50596812
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50030914
104TNF signaling pathway_Homo sapiens_hsa046680.49593306
105Nicotine addiction_Homo sapiens_hsa050330.48663262
106Viral carcinogenesis_Homo sapiens_hsa052030.48452459
107Influenza A_Homo sapiens_hsa051640.47990349
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46569888
109Choline metabolism in cancer_Homo sapiens_hsa052310.46428871
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45612985
111MicroRNAs in cancer_Homo sapiens_hsa052060.44464706
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.43960800
113Purine metabolism_Homo sapiens_hsa002300.40435977
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40165332
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40155160
116Toxoplasmosis_Homo sapiens_hsa051450.40083247
117HTLV-I infection_Homo sapiens_hsa051660.39748548
118Non-homologous end-joining_Homo sapiens_hsa034500.38736612
119Alcoholism_Homo sapiens_hsa050340.38571172
120ErbB signaling pathway_Homo sapiens_hsa040120.38471836
121Oxidative phosphorylation_Homo sapiens_hsa001900.37837472
122Thyroid cancer_Homo sapiens_hsa052160.35045650
123Acute myeloid leukemia_Homo sapiens_hsa052210.34938816
124Fatty acid metabolism_Homo sapiens_hsa012120.34530224
125Lysine degradation_Homo sapiens_hsa003100.34407353
126Chronic myeloid leukemia_Homo sapiens_hsa052200.34046274
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30934452
128Insulin signaling pathway_Homo sapiens_hsa049100.27344665
129Melanogenesis_Homo sapiens_hsa049160.27313585
130MAPK signaling pathway_Homo sapiens_hsa040100.27152316
131Herpes simplex infection_Homo sapiens_hsa051680.24862233
132Hepatitis B_Homo sapiens_hsa051610.24503561
133Viral myocarditis_Homo sapiens_hsa054160.24334098
134Galactose metabolism_Homo sapiens_hsa000520.24272961
135GnRH signaling pathway_Homo sapiens_hsa049120.23929161
136Dopaminergic synapse_Homo sapiens_hsa047280.22901832
137Fructose and mannose metabolism_Homo sapiens_hsa000510.21464496
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18730864
139Synaptic vesicle cycle_Homo sapiens_hsa047210.18578210
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18254377
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18198749
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18058209
143Amphetamine addiction_Homo sapiens_hsa050310.17413325
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.17070404
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.15873617
146Cardiac muscle contraction_Homo sapiens_hsa042600.15488525
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.15220271
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.14455147
149Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.13784124
150Systemic lupus erythematosus_Homo sapiens_hsa053220.13307444

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