LRRC14B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a leucine-rich repeat containing protein that is a member of the PRAME family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.76634757
2actin-myosin filament sliding (GO:0033275)7.51116196
3muscle filament sliding (GO:0030049)7.51116196
4regulation of skeletal muscle contraction (GO:0014819)7.29991504
5myofibril assembly (GO:0030239)7.00033320
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.69916909
7cardiac myofibril assembly (GO:0055003)6.67814228
8sarcoplasmic reticulum calcium ion transport (GO:0070296)6.66800983
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.59339759
10actin-mediated cell contraction (GO:0070252)6.36002758
11response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.35297917
12negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.12636212
13skeletal muscle fiber development (GO:0048741)5.90126134
14regulation of actin filament-based movement (GO:1903115)5.87993312
15regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.85822258
16cardiac muscle contraction (GO:0060048)5.72321428
17regulation of cell communication by electrical coupling (GO:0010649)5.69791364
18negative regulation of potassium ion transmembrane transport (GO:1901380)5.59375829
19regulation of relaxation of muscle (GO:1901077)5.54150878
20plasma membrane repair (GO:0001778)5.47115083
21NADH metabolic process (GO:0006734)5.43792503
22striated muscle contraction (GO:0006941)5.38568385
23skeletal muscle contraction (GO:0003009)5.36777567
24myotube cell development (GO:0014904)5.33636292
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.21331057
26regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.16920720
27adult heart development (GO:0007512)5.05015716
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.03871772
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.01379405
30actomyosin structure organization (GO:0031032)4.96172614
31cardiac muscle cell development (GO:0055013)4.87574871
32regulation of striated muscle contraction (GO:0006942)4.78256703
33glucan catabolic process (GO:0009251)4.76923688
34creatine metabolic process (GO:0006600)4.72686310
35actin filament-based movement (GO:0030048)4.72530885
36muscle fiber development (GO:0048747)4.71147799
37glucan biosynthetic process (GO:0009250)4.70788753
38glycogen biosynthetic process (GO:0005978)4.70788753
39cardiac muscle tissue morphogenesis (GO:0055008)4.66629198
40heart process (GO:0003015)4.66564705
41heart contraction (GO:0060047)4.66564705
42ventricular cardiac muscle cell action potential (GO:0086005)4.59957648
43cardiac cell development (GO:0055006)4.59434202
44regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.49231690
45negative regulation of protein localization to cell surface (GO:2000009)4.49065119
46cellular polysaccharide catabolic process (GO:0044247)4.46737130
47regulation of sarcomere organization (GO:0060297)4.42172692
48skeletal muscle tissue development (GO:0007519)4.40033831
49skeletal muscle adaptation (GO:0043501)4.37164398
50carnitine shuttle (GO:0006853)4.33106611
51regulation of membrane repolarization (GO:0060306)4.30796137
52muscle tissue morphogenesis (GO:0060415)4.26460161
53respiratory electron transport chain (GO:0022904)4.26386483
542-oxoglutarate metabolic process (GO:0006103)4.24558604
55ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.23207921
56bundle of His cell to Purkinje myocyte communication (GO:0086069)4.22018540
57tricarboxylic acid cycle (GO:0006099)4.21080898
58cardiac muscle hypertrophy (GO:0003300)4.16917944
59electron transport chain (GO:0022900)4.13101082
60regulation of acyl-CoA biosynthetic process (GO:0050812)4.12489593
61response to inactivity (GO:0014854)4.09616951
62muscle cell cellular homeostasis (GO:0046716)4.08748243
63striated muscle hypertrophy (GO:0014897)4.06848207
64regulation of cardiac muscle cell contraction (GO:0086004)4.06259003
65positive regulation of myotube differentiation (GO:0010831)4.05169136
66polysaccharide catabolic process (GO:0000272)4.01424939
67skeletal muscle tissue regeneration (GO:0043403)3.95262936
68ATP synthesis coupled proton transport (GO:0015986)3.93544535
69energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93544535
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.91995144
71positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.87693706
72regulation of cardiac muscle contraction (GO:0055117)3.87584838
73cardiac muscle adaptation (GO:0014887)3.83979934
74cardiac muscle hypertrophy in response to stress (GO:0014898)3.83979934
75muscle hypertrophy in response to stress (GO:0003299)3.83979934
76muscle contraction (GO:0006936)3.78654951
77response to muscle activity (GO:0014850)3.76381883
78glycogen metabolic process (GO:0005977)3.74140297
79relaxation of cardiac muscle (GO:0055119)3.70817817
80muscle organ morphogenesis (GO:0048644)3.70764284
81muscle organ development (GO:0007517)3.70250674
82muscle structure development (GO:0061061)3.69497255
83heart trabecula formation (GO:0060347)3.69359388
84gluconeogenesis (GO:0006094)3.68176599
85cellular glucan metabolic process (GO:0006073)3.66522265
86glucan metabolic process (GO:0044042)3.66522265
87muscle adaptation (GO:0043500)3.65847357
88negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.64745285
89negative regulation of calcium ion transmembrane transport (GO:1903170)3.64745285
90fatty acid transmembrane transport (GO:1902001)3.61381303
91regulation of the force of heart contraction (GO:0002026)3.61370865
92negative regulation of muscle hypertrophy (GO:0014741)3.59616980
93muscle cell fate commitment (GO:0042693)3.59174470
94fructose metabolic process (GO:0006000)3.58242835
95positive regulation of cation channel activity (GO:2001259)3.55975559
96muscle hypertrophy (GO:0014896)3.54535773
97regulation of coenzyme metabolic process (GO:0051196)3.54172478
98regulation of cofactor metabolic process (GO:0051193)3.54172478
99muscle system process (GO:0003012)3.52597400
100response to activity (GO:0014823)3.52016055
101regulation of sequestering of triglyceride (GO:0010889)3.51985813
102positive regulation of heart rate (GO:0010460)3.51638912
103membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51066666
104cell communication involved in cardiac conduction (GO:0086065)3.48404040
105regulation of calcium ion transmembrane transporter activity (GO:1901019)3.47724378
106regulation of calcium ion transmembrane transport (GO:1903169)3.47724378
107gonadal mesoderm development (GO:0007506)3.45259548
108cardiac muscle cell action potential (GO:0086001)3.43086534
109regulation of ATP catabolic process (GO:1903289)3.40495880
110regulation of ATPase activity (GO:0043462)3.40495880
111regulation of heart rate (GO:0002027)3.40128743
112cardiac muscle cell action potential involved in contraction (GO:0086002)3.38097095
113striated muscle adaptation (GO:0014888)3.37017485
114muscle cell development (GO:0055001)3.36937999
115regulation of muscle system process (GO:0090257)3.35706824
116regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.34095141
117detection of calcium ion (GO:0005513)3.33350250
118striated muscle atrophy (GO:0014891)3.32891185
119relaxation of muscle (GO:0090075)3.29917185
120hexose biosynthetic process (GO:0019319)3.29511302
121regulation of muscle contraction (GO:0006937)3.27414023
122pyrimidine ribonucleoside catabolic process (GO:0046133)3.27375466
123negative regulation of cardiac muscle hypertrophy (GO:0010614)3.26591234
124cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.23509464
125negative regulation of cytosolic calcium ion concentration (GO:0051481)3.21825541
126negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.19828367
127regulation of heart contraction (GO:0008016)3.19095687
128adrenergic receptor signaling pathway (GO:0071875)3.16705994
129ubiquinone biosynthetic process (GO:0006744)3.14749756
130quinone biosynthetic process (GO:1901663)3.14749756
131glycogen catabolic process (GO:0005980)3.13067210
132striated muscle cell development (GO:0055002)3.12939123
133muscle atrophy (GO:0014889)3.12878435
134cytidine deamination (GO:0009972)3.08666963
135cytidine metabolic process (GO:0046087)3.08666963
136cytidine catabolic process (GO:0006216)3.08666963
137carnitine transmembrane transport (GO:1902603)3.08656223
138cardiac conduction (GO:0061337)3.02308182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.47097605
2EP300_21415370_ChIP-Seq_HL-1_Mouse3.00496486
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.75546081
4BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.57091138
5CDX2_19796622_ChIP-Seq_MESCs_Mouse2.41978599
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35225215
7VDR_22108803_ChIP-Seq_LS180_Human2.28317574
8GBX2_23144817_ChIP-Seq_PC3_Human2.24699669
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24328235
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.20905294
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20730175
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.19992451
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.19395195
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17362931
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12180053
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06200712
17TBX20_22080862_ChIP-Seq_HEART_Mouse2.04559070
18TBX20_22328084_ChIP-Seq_HEART_Mouse2.04559070
19NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.04295975
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04239083
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.00091460
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.97832374
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93864030
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.92669590
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92303950
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92303950
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.88830908
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.80641954
29DROSHA_22980978_ChIP-Seq_HELA_Human1.77926376
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75761138
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74237725
32ZNF263_19887448_ChIP-Seq_K562_Human1.71919938
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67322812
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66145382
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61778037
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61091317
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.60114309
38MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.58048253
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53506967
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50104708
41NFIB_24661679_ChIP-Seq_LUNG_Mouse1.49956893
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.44988120
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44329991
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42365600
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41042141
46AR_21572438_ChIP-Seq_LNCaP_Human1.40241051
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38448702
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35672438
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32647323
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32388063
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32245853
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28171572
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.25550472
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23403863
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23345888
56SMC3_22415368_ChIP-Seq_MEFs_Mouse1.22654323
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22305577
58CTCF_21964334_ChIP-Seq_BJAB-B_Human1.21290757
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21105819
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.20653390
61TAF15_26573619_Chip-Seq_HEK293_Human1.19431144
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19222393
63ER_23166858_ChIP-Seq_MCF-7_Human1.18722164
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18541656
65* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18433818
66STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.17304161
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16829040
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.16127297
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15229522
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13868286
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13212814
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12515072
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11382953
74SPI1_20517297_ChIP-Seq_HL60_Human1.11343077
75CTCF_27219007_Chip-Seq_Bcells_Human1.11314902
76KDM2B_26808549_Chip-Seq_DND41_Human1.10799679
77SMAD4_21799915_ChIP-Seq_A2780_Human1.10489300
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.09469128
79SMAD3_21741376_ChIP-Seq_HESCs_Human1.08893973
80MYC_27129775_Chip-Seq_CORNEA_Mouse1.08792081
81RXR_22158963_ChIP-Seq_LIVER_Mouse1.06911816
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.04920256
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03911186
84CLOCK_20551151_ChIP-Seq_293T_Human1.03902514
85OCT4_20526341_ChIP-Seq_ESCs_Human1.03795440
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03563480
87TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03380460
88GATA4_21415370_ChIP-Seq_HL-1_Mouse1.03264608
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.02109224
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01903469
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01795548
92ZNF274_21170338_ChIP-Seq_K562_Hela1.01621543
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00860964
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.00818965
95TCF7_22412390_ChIP-Seq_EML_Mouse1.00737064
96SA1_27219007_Chip-Seq_Bcells_Human1.00121919
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99784809
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98634312
99CTCF_21964334_Chip-Seq_Bcells_Human0.97847681
100LXR_22292898_ChIP-Seq_THP-1_Human0.97551340
101BCAT_22108803_ChIP-Seq_LS180_Human0.97451772
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96211890
103TP53_20018659_ChIP-ChIP_R1E_Mouse0.95926706
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95041060
105IGF1R_20145208_ChIP-Seq_DFB_Human0.94926330
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94890664
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.93968622
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93556109
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93463092
110CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93123388
111CRX_20693478_ChIP-Seq_RETINA_Mouse0.92238170
112P300_19829295_ChIP-Seq_ESCs_Human0.92115103
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92094731
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92032133
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.91988206
116NFE2_27457419_Chip-Seq_LIVER_Mouse0.91444151
117P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91322065
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.90151554
119ESR2_21235772_ChIP-Seq_MCF-7_Human0.89475850
120GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88433618
121ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88173832
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87259908
123AHR_22903824_ChIP-Seq_MCF-7_Human0.87160986
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86485477
125TP53_18474530_ChIP-ChIP_U2OS_Human0.86336379
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85837817
127WT1_19549856_ChIP-ChIP_CCG9911_Human0.85656240
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85629384
129PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.85402672
130LXR_22158963_ChIP-Seq_LIVER_Mouse0.85178511
131TBL1_22424771_ChIP-Seq_293T_Human0.84770899
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84720643
133E2F1_18555785_Chip-Seq_ESCs_Mouse0.84578247
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83781999
135MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83438518
136LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82683605
137LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82645334
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82304694
139CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82189115
140GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82021657
141NR3C1_23031785_ChIP-Seq_PC12_Mouse0.80993012
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80942758
143NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80942758
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80550263
145SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80535280
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80210945
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79672812
148STAT1_20625510_ChIP-Seq_HELA_Human0.79637400
149SMAD_19615063_ChIP-ChIP_OVARY_Human0.78959945
150TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78719027
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.76070853
152EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.75544629
153PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.74098688
154RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74002130
155CTCF_26484167_Chip-Seq_Bcells_Mouse0.73861081
156RACK7_27058665_Chip-Seq_MCF-7_Human0.73802386
157DPY_21335234_ChIP-Seq_ESCs_Mouse0.73469422
158GATA3_21867929_ChIP-Seq_CD8_Mouse0.73323871
159YY1_22570637_ChIP-Seq_MALME-3M_Human0.71436415
160TP53_23651856_ChIP-Seq_MEFs_Mouse0.71206387
161SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70921228
162P68_20966046_ChIP-Seq_HELA_Human0.68886933
163* SMC4_20622854_ChIP-Seq_HELA_Human0.66112663
164HTT_18923047_ChIP-ChIP_STHdh_Human0.65124708
165OCT4_19829295_ChIP-Seq_ESCs_Human0.63955933
166GATA6_21074721_ChIP-Seq_CACO-2_Human0.62924145

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.24537236
2MP0003646_muscle_fatigue6.06015537
3MP0000751_myopathy5.26914426
4MP0000749_muscle_degeneration4.55149051
5MP0004084_abnormal_cardiac_muscle4.37752680
6MP0004036_abnormal_muscle_relaxation4.15129095
7MP0004215_abnormal_myocardial_fiber4.08023743
8MP0004145_abnormal_muscle_electrophysio4.05449092
9MP0005330_cardiomyopathy3.32414590
10MP0005620_abnormal_muscle_contractility2.90303650
11MP0002106_abnormal_muscle_physiology2.88860683
12MP0004087_abnormal_muscle_fiber2.87291670
13MP0003137_abnormal_impulse_conducting2.75212892
14MP0002972_abnormal_cardiac_muscle2.73148428
15MP0000750_abnormal_muscle_regeneration2.68648933
16MP0004130_abnormal_muscle_cell2.50161602
17MP0000759_abnormal_skeletal_muscle2.41389068
18MP0005369_muscle_phenotype2.38579720
19MP0004484_altered_response_of2.33341580
20MP0000747_muscle_weakness2.32978141
21MP0003828_pulmonary_edema2.24529334
22MP0002269_muscular_atrophy2.22530583
23MP0008775_abnormal_heart_ventricle2.16569852
24MP0001544_abnormal_cardiovascular_syste2.07252504
25MP0005385_cardiovascular_system_phenoty2.07252504
26MP0010630_abnormal_cardiac_muscle1.96797629
27MP0006138_congestive_heart_failure1.94862748
28MP0004085_abnormal_heartbeat1.86349302
29MP0002332_abnormal_exercise_endurance1.69155388
30MP0003950_abnormal_plasma_membrane1.67828308
31MP0004233_abnormal_muscle_weight1.56931403
32MP0006036_abnormal_mitochondrial_physio1.56259106
33MP0005666_abnormal_adipose_tissue1.49253727
34MP0003221_abnormal_cardiomyocyte_apopto1.44208333
35MP0002127_abnormal_cardiovascular_syste1.35294140
36MP0003136_yellow_coat_color1.31037309
37MP0005451_abnormal_body_composition1.28311159
38MP0005670_abnormal_white_adipose1.27653450
39MP0004510_myositis1.18851949
40MP0002108_abnormal_muscle_morphology1.11134150
41MP0004185_abnormal_adipocyte_glucose1.10627587
42MP0001661_extended_life_span1.07951759
43MP0005165_increased_susceptibility_to1.07902068
44MP0002234_abnormal_pharynx_morphology1.04755337
45MP0000343_altered_response_to0.97976414
46MP0005375_adipose_tissue_phenotype0.97499221
47MP0004043_abnormal_pH_regulation0.94736549
48MP0005171_absent_coat_pigmentation0.85478615
49MP0000230_abnormal_systemic_arterial0.82085896
50MP0006035_abnormal_mitochondrial_morpho0.81204398
51MP0003941_abnormal_skin_development0.79422142
52MP0000733_abnormal_muscle_development0.78538108
53MP0000266_abnormal_heart_morphology0.77128938
54MP0004381_abnormal_hair_follicle0.76480951
55MP0003045_fibrosis0.66016624
56MP0000762_abnormal_tongue_morphology0.64264579
57MP0002971_abnormal_brown_adipose0.62809189
58MP0001485_abnormal_pinna_reflex0.60918168
59MP0004270_analgesia0.60610667
60MP0009780_abnormal_chondrocyte_physiolo0.59801751
61MP0002638_abnormal_pupillary_reflex0.59222626
62MP0005409_darkened_coat_color0.58457245
63MP0005266_abnormal_metabolism0.58408659
64MP0000372_irregular_coat_pigmentation0.58285318
65MP0002822_catalepsy0.56566862
66MP0001879_abnormal_lymphatic_vessel0.56477171
67MP0005377_hearing/vestibular/ear_phenot0.55947705
68MP0003878_abnormal_ear_physiology0.55947705
69MP0000920_abnormal_myelination0.54672863
70MP0009250_abnormal_appendicular_skeleto0.53612184
71MP0001727_abnormal_embryo_implantation0.52883443
72MP0003656_abnormal_erythrocyte_physiolo0.52853243
73MP0006072_abnormal_retinal_apoptosis0.52156348
74MP0006292_abnormal_olfactory_placode0.51377517
75MP0000579_abnormal_nail_morphology0.50246483
76MP0001529_abnormal_vocalization0.48096421
77MP0002128_abnormal_blood_circulation0.47457253
78MP0005623_abnormal_meninges_morphology0.45819776
79MP0003567_abnormal_fetal_cardiomyocyte0.44820151
80MP0001299_abnormal_eye_distance/0.44587427
81MP0004134_abnormal_chest_morphology0.43425938
82MP0008569_lethality_at_weaning0.42825773
83MP0004142_abnormal_muscle_tone0.41958733
84MP0003279_aneurysm0.41790006
85MP0005595_abnormal_vascular_smooth0.40493771
86MP0002272_abnormal_nervous_system0.40270327
87MP0003880_abnormal_central_pattern0.40243870
88MP0010368_abnormal_lymphatic_system0.39280642
89MP0006276_abnormal_autonomic_nervous0.38415447
90MP0001486_abnormal_startle_reflex0.38357069
91MP0002078_abnormal_glucose_homeostasis0.38076173
92MP0003879_abnormal_hair_cell0.37404551
93MP0000003_abnormal_adipose_tissue0.37089371
94MP0000026_abnormal_inner_ear0.37061292
95MP0000566_synostosis0.36896755
96MP0004147_increased_porphyrin_level0.36706691
97MP0003948_abnormal_gas_homeostasis0.36628632
98MP0001905_abnormal_dopamine_level0.36405959
99MP0001346_abnormal_lacrimal_gland0.35870528
100MP0005584_abnormal_enzyme/coenzyme_acti0.35249457
101MP0002102_abnormal_ear_morphology0.35196123
102MP0005376_homeostasis/metabolism_phenot0.35047713
103MP0004742_abnormal_vestibular_system0.34610460
104MP0002067_abnormal_sensory_capabilities0.34100165
105MP0005334_abnormal_fat_pad0.33954009
106MP0005535_abnormal_body_temperature0.33917444
107MP0005551_abnormal_eye_electrophysiolog0.33395391
108MP0009672_abnormal_birth_weight0.32587845
109MP0000013_abnormal_adipose_tissue0.31296837
110MP0005423_abnormal_somatic_nervous0.31189061
111MP0002752_abnormal_somatic_nervous0.30910475
112MP0005166_decreased_susceptibility_to0.30346494
113MP0002249_abnormal_larynx_morphology0.30029454
114MP0004924_abnormal_behavior0.29401854
115MP0005452_abnormal_adipose_tissue0.28411488
116MP0002114_abnormal_axial_skeleton0.26516684
117MP0005332_abnormal_amino_acid0.25780125
118MP0005319_abnormal_enzyme/_coenzyme0.25655437
119MP0010030_abnormal_orbit_morphology0.23595559
120MP0005167_abnormal_blood-brain_barrier0.23081401
121MP0005083_abnormal_biliary_tract0.22579197
122MP0002896_abnormal_bone_mineralization0.20976422
123MP0001943_abnormal_respiration0.18791497
124MP0002066_abnormal_motor_capabilities/c0.18155557
125MP0005187_abnormal_penis_morphology0.17724311
126MP0003959_abnormal_lean_body0.16195852
127MP0009115_abnormal_fat_cell0.14843946
128MP0008874_decreased_physiological_sensi0.13909370
129MP0009840_abnormal_foam_cell0.13812645
130MP0005386_behavior/neurological_phenoty0.13592000
131MP0002734_abnormal_mechanical_nocicepti0.10988476
132MP0003705_abnormal_hypodermis_morpholog0.10269090
133MP0003806_abnormal_nucleotide_metabolis0.09938516

Predicted human phenotypes

RankGene SetZ-score
1Muscle hypertrophy of the lower extremities (HP:0008968)7.25167637
2Exercise-induced myalgia (HP:0003738)7.21957806
3Calf muscle hypertrophy (HP:0008981)7.15799220
4Sudden death (HP:0001699)6.74159670
5Exercise-induced muscle cramps (HP:0003710)6.64174553
6Ventricular tachycardia (HP:0004756)6.02169012
7Muscle fiber splitting (HP:0003555)5.95120014
8Abnormality of the calf musculature (HP:0001430)5.41583363
9Atrial fibrillation (HP:0005110)5.12177356
10Hyporeflexia of lower limbs (HP:0002600)5.05441173
11Muscle fiber inclusion bodies (HP:0100299)4.93234709
12Myoglobinuria (HP:0002913)4.87924285
13Centrally nucleated skeletal muscle fibers (HP:0003687)4.82313048
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.75701004
15Primary atrial arrhythmia (HP:0001692)4.75483571
16Abnormality of the left ventricular outflow tract (HP:0011103)4.58721849
17Subaortic stenosis (HP:0001682)4.58721849
18Supraventricular tachycardia (HP:0004755)4.57270705
19Ulnar deviation of the wrist (HP:0003049)4.55921378
20EMG: myopathic abnormalities (HP:0003458)4.48205275
21Supraventricular arrhythmia (HP:0005115)4.44427557
22Lipoatrophy (HP:0100578)4.37426419
23Difficulty running (HP:0009046)4.27727560
24Nemaline bodies (HP:0003798)4.12139229
25Calcaneovalgus deformity (HP:0001848)3.99259616
26Syncope (HP:0001279)3.95383458
27Dilated cardiomyopathy (HP:0001644)3.85382668
28Prolonged QT interval (HP:0001657)3.78129246
29Rhabdomyolysis (HP:0003201)3.69765611
30Myotonia (HP:0002486)3.69056995
31Bundle branch block (HP:0011710)3.66538849
32Right ventricular cardiomyopathy (HP:0011663)3.63810317
33Increased connective tissue (HP:0009025)3.61697539
34Asymmetric septal hypertrophy (HP:0001670)3.58114298
35Deformed tarsal bones (HP:0008119)3.52814922
36Type 1 muscle fiber predominance (HP:0003803)3.45158594
37Acute necrotizing encephalopathy (HP:0006965)3.41976591
38Muscle stiffness (HP:0003552)3.41764141
39Palpitations (HP:0001962)3.36486661
40Frequent falls (HP:0002359)3.34915487
41Abnormal mitochondria in muscle tissue (HP:0008316)3.21664271
42Distal lower limb muscle weakness (HP:0009053)3.19440986
43Heart block (HP:0012722)3.18143196
44Ventricular arrhythmia (HP:0004308)3.15077940
45Malignant hyperthermia (HP:0002047)3.03543145
46Abnormal atrioventricular conduction (HP:0005150)2.99023709
47Abnormal finger flexion creases (HP:0006143)2.88878381
48Progressive macrocephaly (HP:0004481)2.85056922
49Mitochondrial inheritance (HP:0001427)2.83678059
50Mildly elevated creatine phosphokinase (HP:0008180)2.83137294
51Acute encephalopathy (HP:0006846)2.79021391
52Left ventricular hypertrophy (HP:0001712)2.78354700
53Hepatic necrosis (HP:0002605)2.78156044
54Neck muscle weakness (HP:0000467)2.76416530
55Areflexia of lower limbs (HP:0002522)2.75556570
56Myopathic facies (HP:0002058)2.67908703
57Abnormal EKG (HP:0003115)2.60931970
58Hepatocellular necrosis (HP:0001404)2.59264750
59Atrioventricular block (HP:0001678)2.57266937
60Distal arthrogryposis (HP:0005684)2.56587834
61Ventricular fibrillation (HP:0001663)2.55916051
62Bulbar palsy (HP:0001283)2.55540913
63Difficulty climbing stairs (HP:0003551)2.53160088
64Rimmed vacuoles (HP:0003805)2.50972208
65Round ear (HP:0100830)2.50484829
66Increased variability in muscle fiber diameter (HP:0003557)2.49019671
67Progressive muscle weakness (HP:0003323)2.47460886
68Increased CSF lactate (HP:0002490)2.47083839
69Exercise intolerance (HP:0003546)2.46226059
70Abnormality of skeletal muscle fiber size (HP:0012084)2.45552971
71Weak cry (HP:0001612)2.41957808
72Fetal akinesia sequence (HP:0001989)2.39195980
73Increased muscle lipid content (HP:0009058)2.37801949
74Distal lower limb amyotrophy (HP:0008944)2.31657273
75Increased intramyocellular lipid droplets (HP:0012240)2.31492247
76Slender build (HP:0001533)2.31129431
77Ragged-red muscle fibers (HP:0003200)2.28995298
78Abnormality of the calcaneus (HP:0008364)2.28617625
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26022527
80Abnormality of alanine metabolism (HP:0010916)2.26022527
81Hyperalaninemia (HP:0003348)2.26022527
82Gowers sign (HP:0003391)2.24797380
83Ketoacidosis (HP:0001993)2.24094100
84Large for gestational age (HP:0001520)2.21885925
85Muscular dystrophy (HP:0003560)2.18942820
86Cerebral edema (HP:0002181)2.17196568
87Palmoplantar keratoderma (HP:0000982)2.16288019
88Hyperkalemia (HP:0002153)2.16041574
89Fatigable weakness (HP:0003473)2.15683780
90Abnormality of the neuromuscular junction (HP:0003398)2.15683780
91Lipid accumulation in hepatocytes (HP:0006561)2.15110334
92Hip contracture (HP:0003273)2.13668794
93Spinal rigidity (HP:0003306)2.09827216
94Proximal amyotrophy (HP:0007126)2.08125762
95Increased hepatocellular lipid droplets (HP:0006565)2.04834521
96Hypoplastic ischia (HP:0003175)2.02684519
97Lactic acidosis (HP:0003128)2.02592480
98Testicular atrophy (HP:0000029)2.00279964
99Optic disc pallor (HP:0000543)1.99695230
100Waddling gait (HP:0002515)1.98835913
101Abnormality of the shoulder girdle musculature (HP:0001435)1.97771600
102Respiratory failure (HP:0002878)1.95922668
103Foot dorsiflexor weakness (HP:0009027)1.95272687
104Abnormality of the foot musculature (HP:0001436)1.93977224
105Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.91168806
106Renal cortical cysts (HP:0000803)1.86126437
107Generalized muscle weakness (HP:0003324)1.84651668
108Maternal diabetes (HP:0009800)1.84296910
109Limb-girdle muscle atrophy (HP:0003797)1.83406625
110Dicarboxylic aciduria (HP:0003215)1.81645166
111Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81645166
112Scapular winging (HP:0003691)1.81149629
113Respiratory insufficiency due to muscle weakness (HP:0002747)1.80136927
114Lower limb amyotrophy (HP:0007210)1.77797142
115Facial diplegia (HP:0001349)1.76949216
116Absent phalangeal crease (HP:0006109)1.72331102
117Abnormality of the ischium (HP:0003174)1.70063934
118Hyperinsulinemic hypoglycemia (HP:0000825)1.69593507
119EMG: neuropathic changes (HP:0003445)1.69186716
120Limb-girdle muscle weakness (HP:0003325)1.67872715
121Renal Fanconi syndrome (HP:0001994)1.67288414
122Abnormality of the musculature of the pelvis (HP:0001469)1.64828130
123Abnormality of the hip-girdle musculature (HP:0001445)1.64828130
124Methylmalonic acidemia (HP:0002912)1.64173853
125Congenital malformation of the right heart (HP:0011723)1.63125498
126Double outlet right ventricle (HP:0001719)1.63125498
127Metatarsus adductus (HP:0001840)1.61982988
128Pelvic girdle muscle weakness (HP:0003749)1.56290553
129Shoulder girdle muscle weakness (HP:0003547)1.56146569
130Paralysis (HP:0003470)1.52745262
131Popliteal pterygium (HP:0009756)1.52729099
132Nonprogressive disorder (HP:0003680)1.50104877
133Long clavicles (HP:0000890)1.47680832
134Steppage gait (HP:0003376)1.45088065
135Ulnar deviation of finger (HP:0009465)1.44170770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.71252460
2OBSCN5.28314904
3PHKG15.01419076
4PHKG25.01419076
5DMPK2.83703507
6MUSK2.67380656
7LMTK22.59031251
8PINK12.47701227
9PDK32.34783184
10PDK42.34783184
11PIK3CA2.31667152
12MYLK2.28753641
13GRK72.24255259
14PKN11.81665513
15TIE11.80591706
16NME11.75965939
17ZAK1.71577047
18STK391.51644323
19BCKDK1.50276416
20PDK21.43181153
21INSRR1.40633937
22MAPKAPK31.34498187
23CAMK2D1.30299489
24TNIK1.27190895
25EEF2K1.25944222
26WNK41.22679566
27MAP3K71.22540436
28STK241.17154574
29CASK1.14683276
30PAK31.07391820
31PRKD11.04762104
32IRAK31.02327206
33MAPK121.02166182
34PIK3CG1.00901744
35PRKAA20.98974761
36EPHB10.96940948
37TRPM70.88177104
38LIMK10.86262354
39CCNB10.86062805
40ROCK10.84635439
41PRKAA10.83262978
42IRAK20.82929635
43TRIB30.80538845
44MOS0.80509029
45WNK10.78791301
46CAMK2A0.78401505
47DYRK1B0.75794328
48STK160.74353632
49MAPK70.73979019
50PRKCE0.72357362
51MAP3K100.72339247
52ROCK20.69520405
53MAP2K30.69297034
54RIPK10.66625589
55MAP3K130.65094968
56CDC42BPA0.65050553
57CAMK2G0.63469334
58PRPF4B0.61386465
59STK38L0.60466184
60NEK10.58849382
61ERBB30.58590278
62ICK0.58561768
63IRAK10.58508039
64MAPK110.57284831
65MAPK40.57176511
66PRKACA0.56653796
67KSR20.56231989
68STK40.55288313
69PRKACB0.52573672
70EPHB20.52492241
71MARK10.48084218
72CAMK40.47781796
73PRKG10.47655061
74IRAK40.47055314
75MAP2K10.46294932
76EPHA30.45999989
77CAMK10.45064748
78NEK60.42830896
79SGK30.42130869
80TNK20.41486703
81GRK10.41299367
82CAMK2B0.40721075
83EIF2AK20.39331632
84SGK10.39190857
85AKT20.38726273
86ILK0.36262091
87RPS6KL10.35870306
88RPS6KC10.35870306
89TGFBR20.34666639
90MAP2K60.33764193
91PRKCQ0.33161696
92ADRBK10.33124994
93TBK10.32074977
94MAPK150.31899254
95MAPK130.31236937
96PRKACG0.31051187
97ADRBK20.30907833
98MAP3K50.30697282
99NEK90.30318282
100BLK0.30083742
101ARAF0.29251617
102RPS6KA60.28848322
103TAOK20.28666030
104UHMK10.28304396
105SGK20.28052652
106NUAK10.27550880
107NME20.27314335
108SIK10.27296690
109LATS20.27020428
110RPS6KA30.26720948
111RPS6KA10.25072984
112RPS6KB20.24742207
113MAP3K10.24365137
114BMPR20.24244726
115MARK20.24212716
116RPS6KB10.23615306
117PDPK10.23407214
118NTRK20.23368881
119MAPK100.23285011
120SGK4940.22128812
121SGK2230.22128812
122PKN20.21423977
123FES0.20725162
124OXSR10.20560176
125CDK30.20320394
126MAP2K70.20160723
127MAP2K40.19503710
128BMPR1B0.19360847
129PRKD20.19317764
130MAP3K60.18604523
131MTOR0.18115320
132BRAF0.17816601
133PDK10.16982084
134DAPK20.16464410
135RAF10.16071701
136ERN10.11132252
137MARK30.10547720
138MAP3K110.10249671
139ZAP700.09822449
140STK110.07313104
141RPS6KA20.07068123
142MAPK90.05924703
143MAP2K20.04833252
144KSR10.04483324
145LATS10.04288066

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042604.76623620
2Oxidative phosphorylation_Homo sapiens_hsa001904.16288409
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.99152281
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.89451729
5Parkinsons disease_Homo sapiens_hsa050123.87881438
6Dilated cardiomyopathy_Homo sapiens_hsa054143.79388676
7Alzheimers disease_Homo sapiens_hsa050103.13521715
8Propanoate metabolism_Homo sapiens_hsa006402.96522544
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.94398958
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.71940731
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.71355511
12Huntingtons disease_Homo sapiens_hsa050162.48017887
13Fatty acid degradation_Homo sapiens_hsa000712.36714839
14Fatty acid elongation_Homo sapiens_hsa000622.09317068
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04665735
16Fatty acid metabolism_Homo sapiens_hsa012121.83782672
17Pentose phosphate pathway_Homo sapiens_hsa000301.82676873
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70913735
19Arginine biosynthesis_Homo sapiens_hsa002201.69535074
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68734376
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.63155696
22Viral myocarditis_Homo sapiens_hsa054161.62716501
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53907683
24Carbon metabolism_Homo sapiens_hsa012001.51179241
25Fructose and mannose metabolism_Homo sapiens_hsa000511.50488137
26Calcium signaling pathway_Homo sapiens_hsa040201.35621985
27Butanoate metabolism_Homo sapiens_hsa006501.32255070
28Starch and sucrose metabolism_Homo sapiens_hsa005001.17133645
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09203117
30Pyruvate metabolism_Homo sapiens_hsa006201.08895245
31Arginine and proline metabolism_Homo sapiens_hsa003301.08497181
32Oxytocin signaling pathway_Homo sapiens_hsa049210.99559126
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97956080
34beta-Alanine metabolism_Homo sapiens_hsa004100.95929758
35Vascular smooth muscle contraction_Homo sapiens_hsa042700.91921335
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89245694
37Insulin resistance_Homo sapiens_hsa049310.80550337
38Glucagon signaling pathway_Homo sapiens_hsa049220.79043685
39Adipocytokine signaling pathway_Homo sapiens_hsa049200.78493507
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75378789
41Long-term potentiation_Homo sapiens_hsa047200.73678320
42Linoleic acid metabolism_Homo sapiens_hsa005910.73150190
43Circadian rhythm_Homo sapiens_hsa047100.72966599
44PPAR signaling pathway_Homo sapiens_hsa033200.72864439
45Insulin signaling pathway_Homo sapiens_hsa049100.72398962
46Renin secretion_Homo sapiens_hsa049240.68535804
47Taste transduction_Homo sapiens_hsa047420.68091088
48Gastric acid secretion_Homo sapiens_hsa049710.65160892
49Lysine degradation_Homo sapiens_hsa003100.64294960
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63783357
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63582959
52Insulin secretion_Homo sapiens_hsa049110.62664236
53Ether lipid metabolism_Homo sapiens_hsa005650.62271812
54cAMP signaling pathway_Homo sapiens_hsa040240.60943254
55Nitrogen metabolism_Homo sapiens_hsa009100.60060921
56Arachidonic acid metabolism_Homo sapiens_hsa005900.59548014
57Tight junction_Homo sapiens_hsa045300.55796139
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54937569
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54888788
60Fatty acid biosynthesis_Homo sapiens_hsa000610.54827752
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54131665
62Morphine addiction_Homo sapiens_hsa050320.54071887
63Circadian entrainment_Homo sapiens_hsa047130.53837441
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53564722
65Tryptophan metabolism_Homo sapiens_hsa003800.53070084
66Peroxisome_Homo sapiens_hsa041460.52925525
67Serotonergic synapse_Homo sapiens_hsa047260.52491316
68Type II diabetes mellitus_Homo sapiens_hsa049300.51419095
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50593223
70FoxO signaling pathway_Homo sapiens_hsa040680.50171803
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49027648
72AMPK signaling pathway_Homo sapiens_hsa041520.48833635
73Focal adhesion_Homo sapiens_hsa045100.44635585
74Phenylalanine metabolism_Homo sapiens_hsa003600.42835001
75Axon guidance_Homo sapiens_hsa043600.42027011
76Metabolic pathways_Homo sapiens_hsa011000.40165407
77Cholinergic synapse_Homo sapiens_hsa047250.38756901
78Ovarian steroidogenesis_Homo sapiens_hsa049130.38556564
79Pancreatic secretion_Homo sapiens_hsa049720.35325456
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34729138
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34652887
82ECM-receptor interaction_Homo sapiens_hsa045120.34642224
83Glutamatergic synapse_Homo sapiens_hsa047240.32578417
84GABAergic synapse_Homo sapiens_hsa047270.31308192
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31128980
86Nicotine addiction_Homo sapiens_hsa050330.31028592
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30031104
88VEGF signaling pathway_Homo sapiens_hsa043700.29055854
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.28881539
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28875149
91Amphetamine addiction_Homo sapiens_hsa050310.28653055
92mTOR signaling pathway_Homo sapiens_hsa041500.28623773
93Salivary secretion_Homo sapiens_hsa049700.28506387
94Phototransduction_Homo sapiens_hsa047440.25923361
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25140213
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24124488
97Platelet activation_Homo sapiens_hsa046110.23800915
98GnRH signaling pathway_Homo sapiens_hsa049120.23353331
99Tyrosine metabolism_Homo sapiens_hsa003500.23213922
100Glioma_Homo sapiens_hsa052140.21663811
101ABC transporters_Homo sapiens_hsa020100.21490196
102Long-term depression_Homo sapiens_hsa047300.21047358
103MAPK signaling pathway_Homo sapiens_hsa040100.20430345
104Sulfur relay system_Homo sapiens_hsa041220.19860831
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19606358
106Ras signaling pathway_Homo sapiens_hsa040140.17483653
107HIF-1 signaling pathway_Homo sapiens_hsa040660.17337688
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17200444
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.16412157
110Basal cell carcinoma_Homo sapiens_hsa052170.15785334
111Purine metabolism_Homo sapiens_hsa002300.15595768
112Galactose metabolism_Homo sapiens_hsa000520.15444413
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15071841
114Renal cell carcinoma_Homo sapiens_hsa052110.14840467
115Notch signaling pathway_Homo sapiens_hsa043300.14807365
116Regulation of autophagy_Homo sapiens_hsa041400.13508875
117Gap junction_Homo sapiens_hsa045400.13444603
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12079899
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.10278733
120Biosynthesis of amino acids_Homo sapiens_hsa012300.09666540
121Oocyte meiosis_Homo sapiens_hsa041140.09550670
122Amoebiasis_Homo sapiens_hsa051460.08992969
123Bile secretion_Homo sapiens_hsa049760.08765985
124Non-small cell lung cancer_Homo sapiens_hsa052230.07435604
125Endometrial cancer_Homo sapiens_hsa052130.07288434
126Adherens junction_Homo sapiens_hsa045200.07070456
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.06404314
128Melanogenesis_Homo sapiens_hsa049160.05093471

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