LRRC15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.10079255
2keratinization (GO:0031424)8.75141772
3intermediate filament organization (GO:0045109)8.21821208
4peptide cross-linking (GO:0018149)7.22846759
5skin morphogenesis (GO:0043589)7.07680088
6establishment of skin barrier (GO:0061436)6.03549961
7bone trabecula formation (GO:0060346)5.80865039
8bundle of His cell to Purkinje myocyte communication (GO:0086069)5.78717435
9regulation of water loss via skin (GO:0033561)5.54781089
10protein heterotrimerization (GO:0070208)5.28147933
11hair follicle morphogenesis (GO:0031069)5.26918407
12collagen fibril organization (GO:0030199)5.10948760
13hemidesmosome assembly (GO:0031581)5.08241543
14keratinocyte differentiation (GO:0030216)5.00931484
15tooth mineralization (GO:0034505)4.81644677
16citrulline biosynthetic process (GO:0019240)4.73675485
17epidermis development (GO:0008544)4.57012759
18endodermal cell differentiation (GO:0035987)4.52411120
19cell migration involved in heart development (GO:0060973)4.43098287
20intermediate filament cytoskeleton organization (GO:0045104)4.33725522
21substrate-dependent cell migration (GO:0006929)4.29066300
22intermediate filament-based process (GO:0045103)4.23510079
23positive regulation of osteoblast proliferation (GO:0033690)4.19964403
24kidney mesenchyme development (GO:0072074)4.16369344
25keratan sulfate catabolic process (GO:0042340)4.13106257
26cell migration involved in sprouting angiogenesis (GO:0002042)4.10080056
27negative regulation of leukocyte chemotaxis (GO:0002689)4.07677947
28wound healing, spreading of epidermal cells (GO:0035313)4.06795627
29chondrocyte proliferation (GO:0035988)4.05973010
30type B pancreatic cell proliferation (GO:0044342)4.00067155
31blood vessel maturation (GO:0001955)3.97011353
32collagen metabolic process (GO:0032963)3.87433358
33collagen catabolic process (GO:0030574)3.85502355
34epidermal cell differentiation (GO:0009913)3.83323942
35molting cycle process (GO:0022404)3.77568003
36hair cycle process (GO:0022405)3.77568003
37negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.74957814
38extracellular negative regulation of signal transduction (GO:1900116)3.70425415
39extracellular regulation of signal transduction (GO:1900115)3.70425415
40negative regulation of biomineral tissue development (GO:0070168)3.67918750
41cell wall macromolecule metabolic process (GO:0044036)3.62509619
42cell wall macromolecule catabolic process (GO:0016998)3.62509619
43multicellular organismal macromolecule metabolic process (GO:0044259)3.61360760
44negative regulation of smooth muscle cell migration (GO:0014912)3.60760720
45plasma membrane repair (GO:0001778)3.57451708
46negative regulation of BMP signaling pathway (GO:0030514)3.57273800
47negative regulation of osteoblast proliferation (GO:0033689)3.53047846
48epithelial cell-cell adhesion (GO:0090136)3.52540722
49multicellular organismal catabolic process (GO:0044243)3.52328457
50regulation of osteoblast proliferation (GO:0033688)3.52230324
51multicellular organismal water homeostasis (GO:0050891)3.52202431
52atrioventricular valve morphogenesis (GO:0003181)3.49411109
53Golgi transport vesicle coating (GO:0048200)3.48793952
54COPI coating of Golgi vesicle (GO:0048205)3.48793952
55extracellular matrix organization (GO:0030198)3.45188209
56craniofacial suture morphogenesis (GO:0097094)3.44839972
57extracellular matrix disassembly (GO:0022617)3.44596248
58extracellular structure organization (GO:0043062)3.43920680
59* virion attachment to host cell (GO:0019062)3.43044777
60* adhesion of symbiont to host cell (GO:0044650)3.43044777
61planar cell polarity pathway involved in neural tube closure (GO:0090179)3.38831577
62multicellular organismal metabolic process (GO:0044236)3.37868169
63protein retention in ER lumen (GO:0006621)3.35957952
64glomerular basement membrane development (GO:0032836)3.30870518
65hyaluronan catabolic process (GO:0030214)3.29219440
66regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.29157523
67sequestering of extracellular ligand from receptor (GO:0035581)3.28351913
68cranial suture morphogenesis (GO:0060363)3.28315248
69extracellular fibril organization (GO:0043206)3.28186762
70cell-substrate junction assembly (GO:0007044)3.26616197
71citrulline metabolic process (GO:0000052)3.24121344
72maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.21986223
73metanephric mesenchyme development (GO:0072075)3.21534737
74dermatan sulfate metabolic process (GO:0030205)3.21133025
75ventricular cardiac muscle cell action potential (GO:0086005)3.20218394
76regulation of plasminogen activation (GO:0010755)3.20187969
77regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.18426218
78positive regulation of blood vessel endothelial cell migration (GO:0043536)3.16888648
79cardiac myofibril assembly (GO:0055003)3.15608361
80trabecula formation (GO:0060343)3.14229217
81heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.12374668
82regulation of monocyte chemotaxis (GO:0090025)3.10069345
83establishment of tissue polarity (GO:0007164)3.09065800
84establishment of planar polarity (GO:0001736)3.09065800
85vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.08819284
86sarcomere organization (GO:0045214)3.08162597
87regulation of integrin-mediated signaling pathway (GO:2001044)3.04201431
88regulation of establishment of planar polarity (GO:0090175)3.02268136
89ectoderm development (GO:0007398)3.01205793
90molting cycle (GO:0042303)21.3661881
91hair cycle (GO:0042633)21.3661881
92regulation of extracellular matrix disassembly (GO:0010715)2.98971645
93neuron projection extension involved in neuron projection guidance (GO:1902284)2.98734148
94axon extension involved in axon guidance (GO:0048846)2.98734148
95barbed-end actin filament capping (GO:0051016)2.97886594
96skin development (GO:0043588)2.97797291
97wound healing, spreading of cells (GO:0044319)2.96141771
98keratinocyte proliferation (GO:0043616)2.95351052
99fibril organization (GO:0097435)2.95265586
100regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.92601426
101basement membrane organization (GO:0071711)2.90412009
102cochlea morphogenesis (GO:0090103)2.89132834
103endothelial cell morphogenesis (GO:0001886)2.88282028
104cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.85992915
105apoptotic cell clearance (GO:0043277)2.84375231
106dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.83956124
107embryonic cranial skeleton morphogenesis (GO:0048701)2.83721439
108blood vessel endothelial cell migration (GO:0043534)2.83404190
109chondrocyte development (GO:0002063)2.82650187
110protein localization to endosome (GO:0036010)2.81696152
111substrate adhesion-dependent cell spreading (GO:0034446)2.81694166
112activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.80861355
113water homeostasis (GO:0030104)2.79534731
114* adhesion of symbiont to host (GO:0044406)2.79069770
115endocardial cushion development (GO:0003197)2.78225328
116protein hydroxylation (GO:0018126)2.77377914
117positive regulation of axon extension (GO:0045773)2.75512019
118positive regulation of endothelial cell apoptotic process (GO:2000353)2.75306456
119cellular response to vitamin D (GO:0071305)2.75118179
120regulation of collagen metabolic process (GO:0010712)2.74802883
121regulation of cardioblast differentiation (GO:0051890)2.74248267
122glycosaminoglycan catabolic process (GO:0006027)2.74054785
123G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.73566740
124peptidyl-proline hydroxylation (GO:0019511)2.68530642
125wound healing (GO:0042060)2.63004342
126peptidyl-arginine modification (GO:0018195)2.61986777
127regulation of hair follicle development (GO:0051797)2.61871114
128hair follicle development (GO:0001942)2.59438021
129negative regulation of fatty acid transport (GO:2000192)2.59158529
130negative regulation of keratinocyte proliferation (GO:0010839)2.57150517
131gap junction assembly (GO:0016264)2.56343746
132myofibril assembly (GO:0030239)2.53120851
133negative regulation of chondrocyte differentiation (GO:0032331)2.52300348
134stress fiber assembly (GO:0043149)2.50408990
135outer ear morphogenesis (GO:0042473)2.49963786
136vascular endothelial growth factor signaling pathway (GO:0038084)2.47460293
137cellular response to vitamin (GO:0071295)2.44688241
138eyelid development in camera-type eye (GO:0061029)2.44234857
139non-canonical Wnt signaling pathway (GO:0035567)2.44162070
140regulation of tight junction assembly (GO:2000810)2.41895536
141negative regulation of cell fate specification (GO:0009996)2.40042523
142extracellular matrix assembly (GO:0085029)2.39291448
143hippo signaling (GO:0035329)2.35343497
144mesenchymal-epithelial cell signaling (GO:0060638)2.35077845
145muscle filament sliding (GO:0030049)2.34828193
146actin-myosin filament sliding (GO:0033275)2.34828193
147outflow tract septum morphogenesis (GO:0003148)2.34792219
148dermatan sulfate biosynthetic process (GO:0030208)2.34605886
149positive regulation of epithelial to mesenchymal transition (GO:0010718)2.33958770
150epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.32012760
151Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.31133289
152cellular response to amino acid stimulus (GO:0071230)2.31032864
153negative regulation of cartilage development (GO:0061037)2.30347840
154cell adhesion mediated by integrin (GO:0033627)2.29280756
155epithelium development (GO:0060429)2.29068141
156polarized epithelial cell differentiation (GO:0030859)2.28299352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.81262797
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.80719981
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.44703135
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.26602827
5P63_26484246_Chip-Seq_KERATINOCYTES_Human2.97803398
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.81091467
7* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.74751545
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.40259472
9RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.16983697
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.14069454
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07578360
12TP63_17297297_ChIP-ChIP_HaCaT_Human11.8510183
13SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.97664573
14SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.97664573
15TP53_20018659_ChIP-ChIP_R1E_Mouse1.90796425
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90509219
17SOX9_24532713_ChIP-Seq_HFSC_Mouse1.86123637
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.85439579
19CLOCK_20551151_ChIP-Seq_293T_Human1.80549294
20ATF3_27146783_Chip-Seq_COLON_Human1.78581133
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74808791
22RACK7_27058665_Chip-Seq_MCF-7_Human1.68601830
23ZNF263_19887448_ChIP-Seq_K562_Human1.68476274
24CJUN_26792858_Chip-Seq_BT549_Human1.67309364
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63301901
26UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.61994558
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.60209056
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.60013497
29P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58596269
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.58454206
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53930358
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.53925727
33UBF1/2_26484160_Chip-Seq_HMECs_Human1.53763469
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53761005
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53761005
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52575409
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.52067825
38JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47860336
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.46667773
40JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44876712
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42930677
42TP53_16413492_ChIP-PET_HCT116_Human1.42125800
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40753854
44LXR_22292898_ChIP-Seq_THP-1_Human1.40071310
45SA1_22415368_ChIP-Seq_MEFs_Mouse1.39932189
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39343975
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39331353
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39331353
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.38572260
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37566110
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36106058
52CSB_26484114_Chip-Seq_FIBROBLAST_Human1.34583892
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.33659684
54* TBX20_22328084_ChIP-Seq_HEART_Mouse1.28700443
55* TBX20_22080862_ChIP-Seq_HEART_Mouse1.28700443
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27252173
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26010810
58* TP63_22573176_ChIP-Seq_HFKS_Human1.24401433
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24392589
60* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23893953
61TP53_22127205_ChIP-Seq_IMR90_Human1.23748826
62CTCF_20526341_ChIP-Seq_ESCs_Human1.22168648
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21831767
64* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21156301
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20461825
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19640250
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19075833
68BRD4_25478319_ChIP-Seq_HGPS_Human1.18486077
69TP53_18474530_ChIP-ChIP_U2OS_Human1.18272535
70E2F1_20622854_ChIP-Seq_HELA_Human1.18005938
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17143531
72JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16709895
73* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14370277
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13442925
75CTCF_27219007_Chip-Seq_Bcells_Human1.09389986
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09243664
77GATA3_24758297_ChIP-Seq_MCF-7_Human1.07758785
78EGR1_19032775_ChIP-ChIP_M12_Human1.05184619
79KLF5_25053715_ChIP-Seq_YYC3_Human1.05173974
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04849103
81ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04848848
82* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.04585396
83TP63_23658742_ChIP-Seq_EP156T_Human1.04509477
84RUNX1_27514584_Chip-Seq_MCF-7_Human1.04239168
85MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03967278
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03663175
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03512551
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03413560
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02236697
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01944948
91TP53_23651856_ChIP-Seq_MEFs_Mouse1.01384349
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00476758
93KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99677717
94SOX2_20726797_ChIP-Seq_SW620_Human0.98760188
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.98075190
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97203367
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96190785
98RXR_22108803_ChIP-Seq_LS180_Human0.96090811
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95682147
100P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95450939
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94068855
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.93340341
103RNF2_27304074_Chip-Seq_ESCs_Mouse0.93214772
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.91301869
105KDM2B_26808549_Chip-Seq_DND41_Human0.91232694
106* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.91072938
107MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90754919
108NFI_21473784_ChIP-Seq_ESCs_Mouse0.88301766
109ELF1_20517297_ChIP-Seq_JURKAT_Human0.88235614
110YY1_22570637_ChIP-Seq_MALME-3M_Human0.87254618
111NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86454143
112KDM2B_26808549_Chip-Seq_K562_Human0.85393511
113AHR_22903824_ChIP-Seq_MCF-7_Human0.85018328
114TCF4_18268006_ChIP-ChIP_LS174T_Human0.84991998
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84916750
116SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84380432
117RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84204579
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84049276
119SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83717641
120* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83620652
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82958534
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82615504
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82372299
124EGR1_19374776_ChIP-ChIP_THP-1_Human0.82335744
125BCL6_27268052_Chip-Seq_Bcells_Human0.82299020
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82219921
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81181600
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.80921249
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80904947
130SMC4_20622854_ChIP-Seq_HELA_Human0.80890780
131NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80573855
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80462926
133ISL1_27105846_Chip-Seq_CPCs_Mouse0.80418334
134ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78883275
135THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78506736
136KDM2B_26808549_Chip-Seq_JURKAT_Human0.77633924
137MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77271509
138P68_20966046_ChIP-Seq_HELA_Human0.76727633
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76129703
140SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.75863073
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.75717128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile6.78236738
2MP0008438_abnormal_cutaneous_collagen5.44046641
3MP0000579_abnormal_nail_morphology5.38813019
4MP0003705_abnormal_hypodermis_morpholog4.67794912
5MP0002796_impaired_skin_barrier4.19842367
6MP0002098_abnormal_vibrissa_morphology3.94131957
7MP0000647_abnormal_sebaceous_gland3.63085113
8MP0000383_abnormal_hair_follicle3.07179234
9MP0005503_abnormal_tendon_morphology3.03937475
10MP0010234_abnormal_vibrissa_follicle2.85770057
11MP0002060_abnormal_skin_morphology2.83822300
12MP0005501_abnormal_skin_physiology2.73597050
13MP0010678_abnormal_skin_adnexa2.61385242
14MP0000377_abnormal_hair_follicle2.57733534
15MP0003566_abnormal_cell_adhesion2.30312193
16MP0001243_abnormal_dermal_layer2.29541731
17MP0000427_abnormal_hair_cycle2.16077710
18MP0002254_reproductive_system_inflammat2.15924924
19MP0003941_abnormal_skin_development2.05236331
20MP0001216_abnormal_epidermal_layer1.98839696
21MP0010771_integument_phenotype1.94881885
22MP0003279_aneurysm1.92338298
23MP0010368_abnormal_lymphatic_system1.69325154
24MP0003453_abnormal_keratinocyte_physiol1.67343974
25MP0009053_abnormal_anal_canal1.57955642
26MP0004272_abnormal_basement_membrane1.54238454
27MP0004947_skin_inflammation1.53346465
28MP0001958_emphysema1.52733252
29MP0000762_abnormal_tongue_morphology1.47537634
30MP0000467_abnormal_esophagus_morphology1.47534517
31MP0000751_myopathy1.45729892
32MP0006054_spinal_hemorrhage1.43510956
33MP0005623_abnormal_meninges_morphology1.41909771
34MP0004084_abnormal_cardiac_muscle1.39654765
35MP0005023_abnormal_wound_healing1.39278296
36MP0000367_abnormal_coat/_hair1.35501835
37MP0002837_dystrophic_cardiac_calcinosis1.35075246
38MP0010352_gastrointestinal_tract_polyps1.33756293
39MP0002234_abnormal_pharynx_morphology1.33744681
40MP0005508_abnormal_skeleton_morphology1.33741799
41MP0005171_absent_coat_pigmentation1.31302695
42MP0000534_abnormal_ureter_morphology1.29045393
43MP0010030_abnormal_orbit_morphology1.24799052
44MP0002877_abnormal_melanocyte_morpholog1.24374677
45MP0009384_cardiac_valve_regurgitation1.23372535
46MP0009931_abnormal_skin_appearance1.22731565
47MP0002998_abnormal_bone_remodeling1.21529795
48MP0005257_abnormal_intraocular_pressure1.17738517
49MP0004858_abnormal_nervous_system1.14541744
50MP0001542_abnormal_bone_strength1.09787194
51MP0009780_abnormal_chondrocyte_physiolo1.08345661
52MP0000750_abnormal_muscle_regeneration1.06610088
53MP0000163_abnormal_cartilage_morphology1.04745670
54MP0003385_abnormal_body_wall1.04419025
55MP0005330_cardiomyopathy1.02644349
56MP0005595_abnormal_vascular_smooth1.01622025
57MP0004185_abnormal_adipocyte_glucose1.01457389
58MP0009379_abnormal_foot_pigmentation0.98559779
59MP0004381_abnormal_hair_follicle0.98149575
60MP0003795_abnormal_bone_structure0.97987704
61MP0002113_abnormal_skeleton_development0.94657713
62MP0002896_abnormal_bone_mineralization0.93614502
63MP0009250_abnormal_appendicular_skeleto0.92930779
64MP0000733_abnormal_muscle_development0.91716947
65MP0002108_abnormal_muscle_morphology0.90343356
66MP0003045_fibrosis0.88026567
67MP0004134_abnormal_chest_morphology0.87535030
68MP0003942_abnormal_urinary_system0.86662912
69MP0006138_congestive_heart_failure0.86432276
70MP0002282_abnormal_trachea_morphology0.85329303
71MP0010386_abnormal_urinary_bladder0.85263792
72MP0003755_abnormal_palate_morphology0.84872899
73MP0003300_gastrointestinal_ulcer0.83776153
74MP0001348_abnormal_lacrimal_gland0.83740416
75MP0004087_abnormal_muscle_fiber0.83026257
76MP0001191_abnormal_skin_condition0.82119921
77MP0001533_abnormal_skeleton_physiology0.81009209
78MP0005164_abnormal_response_to0.80018554
79MP0001299_abnormal_eye_distance/0.74642522
80MP0000428_abnormal_craniofacial_morphol0.73325056
81MP0005058_abnormal_lysosome_morphology0.72375744
82MP0003091_abnormal_cell_migration0.72014083
83MP0004215_abnormal_myocardial_fiber0.70741311
84MP0002295_abnormal_pulmonary_circulatio0.70739417
85MP0000432_abnormal_head_morphology0.70498952
86MP0003191_abnormal_cellular_cholesterol0.68248369
87MP0005165_increased_susceptibility_to0.68244042
88MP0005390_skeleton_phenotype0.67719761
89MP0005388_respiratory_system_phenotype0.67412260
90MP0002133_abnormal_respiratory_system0.67412260
91MP0002168_other_aberrant_phenotype0.66341105
92MP0004036_abnormal_muscle_relaxation0.65666586
93MP0000013_abnormal_adipose_tissue0.65199346
94MP0002972_abnormal_cardiac_muscle0.64526603
95MP0010630_abnormal_cardiac_muscle0.64517409
96MP0002109_abnormal_limb_morphology0.64247359
97MP0002128_abnormal_blood_circulation0.64130257
98MP0001879_abnormal_lymphatic_vessel0.63830337
99MP0000759_abnormal_skeletal_muscle0.62765265
100MP0000749_muscle_degeneration0.62515598
101MP0005666_abnormal_adipose_tissue0.62488184
102MP0002177_abnormal_outer_ear0.61928555
103MP0005197_abnormal_uvea_morphology0.61791699
104MP0002114_abnormal_axial_skeleton0.61708643
105MP0001849_ear_inflammation0.60548052
106MP0003935_abnormal_craniofacial_develop0.60114851
107MP0001614_abnormal_blood_vessel0.58769475
108MP0003448_altered_tumor_morphology0.58656798
109MP0001340_abnormal_eyelid_morphology0.58653884
110MP0002115_abnormal_skeleton_extremities0.58419459
111MP0002111_abnormal_tail_morphology0.58031421
112MP0001661_extended_life_span0.58020370
113MP0001544_abnormal_cardiovascular_syste0.58001526
114MP0005385_cardiovascular_system_phenoty0.58001526
115MP0003115_abnormal_respiratory_system0.56544942
116MP0005375_adipose_tissue_phenotype0.56374450
117MP0001175_abnormal_lung_morphology0.56243447
118MP0001784_abnormal_fluid_regulation0.53479779
119MP0006082_CNS_inflammation0.52997381
120MP0002933_joint_inflammation0.52216492
121MP0000343_altered_response_to0.52093085
122MP0005076_abnormal_cell_differentiation0.51926467
123MP0000767_abnormal_smooth_muscle0.51877183
124MP0005369_muscle_phenotype0.51832514
125MP0002116_abnormal_craniofacial_bone0.51804492
126MP0005248_abnormal_Harderian_gland0.51703062
127MP0003950_abnormal_plasma_membrane0.51506138
128MP0000627_abnormal_mammary_gland0.51434353
129MP0002932_abnormal_joint_morphology0.51148341
130MP0005367_renal/urinary_system_phenotyp0.51145774
131MP0000516_abnormal_urinary_system0.51145774
132MP0009840_abnormal_foam_cell0.50923322
133MP0005409_darkened_coat_color0.50826387
134MP0008775_abnormal_heart_ventricle0.50457193
135MP0000003_abnormal_adipose_tissue0.49694692
136MP0000462_abnormal_digestive_system0.49246215
137MP0000569_abnormal_digit_pigmentation0.46972804

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)8.28535643
2Woolly hair (HP:0002224)7.10707516
3Pili torti (HP:0003777)6.28606510
4Protrusio acetabuli (HP:0003179)6.21834785
5Premature rupture of membranes (HP:0001788)6.16906357
6Follicular hyperkeratosis (HP:0007502)5.84936588
7Slow-growing hair (HP:0002217)5.34247268
8Abnormality of hair growth rate (HP:0011363)5.34247268
9Right ventricular cardiomyopathy (HP:0011663)5.05092068
10Atrophic scars (HP:0001075)4.93078003
11Brittle hair (HP:0002299)4.86406763
12Alopecia of scalp (HP:0002293)4.42163293
13Abnormality of nail color (HP:0100643)4.31581457
14Nail dystrophy (HP:0008404)4.17852851
15Vascular tortuosity (HP:0004948)4.05282093
16Fragile skin (HP:0001030)4.03212169
17Peritonitis (HP:0002586)3.93836545
18Abnormal hair laboratory examination (HP:0003328)3.71624387
19Increased connective tissue (HP:0009025)3.67270797
20Fragile nails (HP:0001808)3.64708745
21Mild short stature (HP:0003502)3.64352584
22Ventricular tachycardia (HP:0004756)3.56612084
23Ankle contracture (HP:0006466)3.51107916
24Arterial tortuosity (HP:0005116)3.47650332
25Soft skin (HP:0000977)3.40693096
26Aortic dissection (HP:0002647)3.35627047
27Shallow orbits (HP:0000586)3.34663742
28Spondylolisthesis (HP:0003302)3.29340572
29Palmoplantar hyperkeratosis (HP:0000972)3.26580265
30Onycholysis (HP:0001806)3.17839180
31Thick nail (HP:0001805)3.14810731
32Cerebral aneurysm (HP:0004944)3.10743844
33Plantar hyperkeratosis (HP:0007556)3.05795050
34Type 1 muscle fiber predominance (HP:0003803)3.05522292
35Palmar hyperkeratosis (HP:0010765)3.05114363
36Increased IgE level (HP:0003212)3.03612780
37Milia (HP:0001056)3.01235500
38Broad metatarsal (HP:0001783)3.01203730
39Absent frontal sinuses (HP:0002688)2.97011760
40Bladder diverticulum (HP:0000015)2.92116428
41Mitral valve prolapse (HP:0001634)2.90571290
42Genu recurvatum (HP:0002816)2.89481943
43Metaphyseal dysplasia (HP:0100255)2.87410011
44Dilatation of the ascending aorta (HP:0005111)2.81388224
45Neonatal short-limb short stature (HP:0008921)2.77351983
46Sudden death (HP:0001699)2.77262188
47Congenital, generalized hypertrichosis (HP:0004540)2.69073793
48Muscle fiber splitting (HP:0003555)2.68092248
49Joint laxity (HP:0001388)2.65096912
50Persistence of primary teeth (HP:0006335)2.62509013
51Broad ribs (HP:0000885)2.58597976
52Fine hair (HP:0002213)2.55567185
53Abnormality of the frontal sinuses (HP:0002687)2.53632023
54Sparse eyelashes (HP:0000653)2.51232060
55Joint stiffness (HP:0001387)2.51010919
56Aortic regurgitation (HP:0001659)2.50912735
57Spinal rigidity (HP:0003306)2.48525870
58Blue sclerae (HP:0000592)2.48224073
59Abnormality of dentin (HP:0010299)2.48168677
60Ulnar bowing (HP:0003031)2.46707219
61Hyporeflexia of lower limbs (HP:0002600)2.43884466
62Wormian bones (HP:0002645)2.42042921
63Biconcave vertebral bodies (HP:0004586)2.39035505
64Delayed closure of the anterior fontanelle (HP:0001476)2.37701016
65Femoral bowing (HP:0002980)2.36941081
66Slender build (HP:0001533)2.36769234
67Hypoventilation (HP:0002791)2.36269908
68Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.35736245
69Mitral regurgitation (HP:0001653)2.32767534
70Mildly elevated creatine phosphokinase (HP:0008180)2.32520482
71Natal tooth (HP:0000695)2.31971493
72Tibial bowing (HP:0002982)2.29836036
73Erythema (HP:0010783)2.26939305
74Amelogenesis imperfecta (HP:0000705)2.26581472
75Delayed cranial suture closure (HP:0000270)2.24776084
76Conjunctival hamartoma (HP:0100780)2.20299925
77Coxa vara (HP:0002812)2.19031664
78Vertebral compression fractures (HP:0002953)2.19000102
79Aortic valve stenosis (HP:0001650)2.18984492
80Ovoid vertebral bodies (HP:0003300)2.18945734
81Aneurysm (HP:0002617)2.18067056
82Advanced eruption of teeth (HP:0006288)2.16497550
83Mitral stenosis (HP:0001718)2.15138922
84Hyperextensible skin (HP:0000974)2.12201690
85Metaphyseal cupping (HP:0003021)2.10404654
86Elbow flexion contracture (HP:0002987)2.10114894
87Increased variability in muscle fiber diameter (HP:0003557)2.07010391
88Distal lower limb muscle weakness (HP:0009053)2.05722453
89Osteolytic defects of the phalanges of the hand (HP:0009771)2.05439864
90Osteolytic defects of the hand bones (HP:0009699)2.05439864
91Coronal craniosynostosis (HP:0004440)2.05071748
92Palmoplantar keratoderma (HP:0000982)2.04796341
93Cervical subluxation (HP:0003308)2.02911820
94Wide anterior fontanel (HP:0000260)2.02872645
95Generalized amyotrophy (HP:0003700)2.02606282
96Hallux valgus (HP:0001822)2.02215306
97Camptodactyly of toe (HP:0001836)2.00457871
98Deviation of the hallux (HP:0010051)1.99629911
99Irregular vertebral endplates (HP:0003301)1.97774700
100Cardiovascular calcification (HP:0011915)1.97667560
101Abnormality of skull ossification (HP:0002703)1.96108664
102Distal lower limb amyotrophy (HP:0008944)1.95450006
103Short nail (HP:0001799)1.93088908
104Neck muscle weakness (HP:0000467)1.92344371
105Achilles tendon contracture (HP:0001771)1.90879599
106Abnormal delivery (HP:0001787)1.89531774
107Aortic aneurysm (HP:0004942)1.88772481
108Thin bony cortex (HP:0002753)1.87665364
109Curly hair (HP:0002212)1.87230556
110Spinal cord compression (HP:0002176)1.86853751
111Disproportionate tall stature (HP:0001519)1.86812427
112Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.85426887
113Breech presentation (HP:0001623)1.83598051
114Abnormal blistering of the skin (HP:0008066)1.83375577
115Venous abnormality (HP:0002624)1.83232926
116Cupped ribs (HP:0000887)1.83186829
117Ridged nail (HP:0001807)1.83015645
118Congenital ichthyosiform erythroderma (HP:0007431)1.82510142
119Flared iliac wings (HP:0002869)1.81186774
120Craniofacial hyperostosis (HP:0004493)1.81033689
121Infantile muscular hypotonia (HP:0008947)1.80443721
122Abnormality of skeletal muscle fiber size (HP:0012084)1.80332631
123Ulnar deviation of the wrist (HP:0003049)1.79835469
124Nonimmune hydrops fetalis (HP:0001790)1.79427853
125Venous insufficiency (HP:0005293)1.76838576
126Decreased skull ossification (HP:0004331)1.75526833
127Inguinal hernia (HP:0000023)1.75287578
128Protruding ear (HP:0000411)1.75152500
129Limb-girdle muscle weakness (HP:0003325)1.74605752
130Broad long bones (HP:0005622)1.74398313
131Small epiphyses (HP:0010585)1.73306610
132Abnormality of the vertebral endplates (HP:0005106)1.72975056
133Flat cornea (HP:0007720)1.72698551
134Hypoplastic ischia (HP:0003175)1.72431069
135Bowel diverticulosis (HP:0005222)1.72391096
136Overgrowth (HP:0001548)1.71899163
137Limited hip movement (HP:0008800)1.71283180
138Abnormality of the parietal bone (HP:0002696)1.71047903
139Abnormality of the Achilles tendon (HP:0005109)1.69859839
140Difficulty climbing stairs (HP:0003551)1.69167324
141Ectopia lentis (HP:0001083)1.69048179
142Wrist flexion contracture (HP:0001239)1.67543662
143Osteoarthritis (HP:0002758)1.66828879
144Aplasia cutis congenita (HP:0001057)1.65990471
145Abnormality of the acetabulum (HP:0003170)1.65959835
146Lipoatrophy (HP:0100578)1.65798960
147Abnormality of the peritoneum (HP:0002585)1.65641405
148Ventricular fibrillation (HP:0001663)1.61564814
149Oral leukoplakia (HP:0002745)1.60364524
150Round ear (HP:0100830)1.59802749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.47118349
2TTN4.18349897
3NEK93.65310805
4DDR23.27950242
5LATS13.13826734
6EPHB22.87845976
7PDGFRA2.84817979
8FER2.70579770
9EPHA22.63533458
10PKN22.62318121
11ERN12.59824440
12LATS22.34955591
13MAP3K32.30261761
14PIM22.05542346
15MAPKAPK32.03372820
16MOS2.00454960
17DMPK1.88407678
18SIK11.64787492
19KIT1.63332016
20MYLK1.61857215
21BMX1.61810468
22PIK3CA1.55777353
23FGFR11.55551889
24TAOK11.53731360
25RIPK11.52437162
26TRPM71.52038863
27PAK31.47609107
28PAK21.46803819
29PTK61.38814736
30EPHA31.38494242
31AKT31.37603892
32STK38L1.37377565
33EPHB11.29255860
34PAK61.27992622
35PTK21.27758732
36MAP2K31.10647070
37LRRK21.07699412
38MAP3K61.04940834
39LMTK21.04489110
40MAPK71.04139640
41FGFR41.01738304
42MET0.99951688
43TGFBR20.98677602
44CDK60.98203344
45GRK70.97253143
46NEK10.96802126
47PRKD10.96787800
48EEF2K0.95718959
49PDK30.94128866
50PDK40.94128866
51SCYL20.93014100
52ADRBK10.92681551
53MTOR0.91021333
54PIK3CG0.90949909
55CDC42BPA0.89269598
56STK30.89029046
57DYRK1B0.88300017
58PDK20.88256919
59FGFR30.84714836
60PDGFRB0.84217009
61MAP3K50.83461012
62PRPF4B0.82347952
63DAPK30.81719082
64RPS6KA40.81249112
65OBSCN0.81067106
66ROCK10.81016401
67FGFR20.80567455
68ILK0.80130216
69PAK40.76148890
70PHKG10.76069570
71PHKG20.76069570
72MAP3K100.75203051
73IRAK30.74145593
74RPS6KA20.73121646
75TESK10.71821506
76TGFBR10.71606688
77MAP3K110.69755159
78CDK120.68858525
79JAK30.67274208
80ERBB30.66137091
81PTK2B0.65847974
82PRKG20.65721177
83STK380.65709850
84PRKD20.63277085
85MAPKAPK20.62981321
86MAP3K130.61389207
87MAP3K70.61308117
88ERBB40.58814775
89WNK10.57722773
90PAK10.53001184
91LIMK10.51374460
92TYK20.51228868
93KSR20.50508606
94ZAP700.47531457
95ARAF0.46222992
96RPS6KB20.45619076
97ICK0.44423294
98JAK10.43406400
99MST1R0.43348061
100TBK10.42527637
101PRKCH0.41877891
102ROCK20.41585196
103MAPK120.40108344
104PRKD30.39748075
105TAOK20.38843560
106MELK0.38742736
107MAP2K10.38311745
108MARK20.37903754
109GSK3A0.36333952
110MAP3K140.34670021
111KDR0.34661596
112TESK20.34121754
113MAPK40.33953559
114ABL20.32757553
115RPS6KC10.32598907
116RPS6KL10.32598907
117RET0.32136843
118ALK0.30646650
119STK240.28845781
120CDK150.28250593
121MAP3K20.28126332
122MAPK110.27427662
123HIPK20.26794201
124PRKCE0.26457647
125CDK11A0.26435272
126PDPK10.26182999
127CAMK40.26044899
128MAP3K10.25658121
129ERBB20.24935729
130TYRO30.24399739
131MAP2K60.23862844
132SRC0.23629697
133INSR0.23581553
134BCKDK0.23381748
135FLT30.22183718
136NTRK10.22075644

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.27189894
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.07264676
3Protein digestion and absorption_Homo sapiens_hsa049742.79313723
4Focal adhesion_Homo sapiens_hsa045102.76019359
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.66299837
6Dilated cardiomyopathy_Homo sapiens_hsa054142.65982454
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.64357465
8Proteoglycans in cancer_Homo sapiens_hsa052052.27383666
9Basal cell carcinoma_Homo sapiens_hsa052172.19986649
10Amoebiasis_Homo sapiens_hsa051462.13067678
11Adherens junction_Homo sapiens_hsa045201.98723171
12Bladder cancer_Homo sapiens_hsa052191.97338349
13Other glycan degradation_Homo sapiens_hsa005111.92732375
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.87328673
15Hippo signaling pathway_Homo sapiens_hsa043901.84302271
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81631619
17Linoleic acid metabolism_Homo sapiens_hsa005911.78409744
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75510436
19Hedgehog signaling pathway_Homo sapiens_hsa043401.61477827
20MicroRNAs in cancer_Homo sapiens_hsa052061.61050441
21p53 signaling pathway_Homo sapiens_hsa041151.60044785
22Small cell lung cancer_Homo sapiens_hsa052221.56702659
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44964243
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44852513
25TGF-beta signaling pathway_Homo sapiens_hsa043501.44643140
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.28057691
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.27845348
28Viral myocarditis_Homo sapiens_hsa054161.26890172
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25790424
30Tight junction_Homo sapiens_hsa045301.25114794
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.20968075
32Regulation of actin cytoskeleton_Homo sapiens_hsa048101.19570806
33VEGF signaling pathway_Homo sapiens_hsa043701.19244888
34Malaria_Homo sapiens_hsa051441.18961589
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15827858
36Glioma_Homo sapiens_hsa052141.15190071
37Chronic myeloid leukemia_Homo sapiens_hsa052201.13756421
38Melanoma_Homo sapiens_hsa052181.12516532
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06861372
40Fatty acid elongation_Homo sapiens_hsa000621.05831932
41Melanogenesis_Homo sapiens_hsa049161.01747457
42Pertussis_Homo sapiens_hsa051331.01323517
43Fatty acid degradation_Homo sapiens_hsa000711.00508338
44Axon guidance_Homo sapiens_hsa043601.00253970
45Arachidonic acid metabolism_Homo sapiens_hsa005900.98504935
46Vibrio cholerae infection_Homo sapiens_hsa051100.98424892
47Prion diseases_Homo sapiens_hsa050200.97944367
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97811404
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.96186630
50Toxoplasmosis_Homo sapiens_hsa051450.95658862
51Acute myeloid leukemia_Homo sapiens_hsa052210.95341987
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95140178
53Platelet activation_Homo sapiens_hsa046110.94535223
54Fat digestion and absorption_Homo sapiens_hsa049750.94111983
55Wnt signaling pathway_Homo sapiens_hsa043100.93014356
56GnRH signaling pathway_Homo sapiens_hsa049120.91376144
57Complement and coagulation cascades_Homo sapiens_hsa046100.91321176
58Pathways in cancer_Homo sapiens_hsa052000.90458718
59Insulin resistance_Homo sapiens_hsa049310.88641621
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88446595
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84867093
62Cardiac muscle contraction_Homo sapiens_hsa042600.84533168
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.84325873
64Notch signaling pathway_Homo sapiens_hsa043300.84196869
65N-Glycan biosynthesis_Homo sapiens_hsa005100.80336322
66Rap1 signaling pathway_Homo sapiens_hsa040150.79767983
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78312248
68PPAR signaling pathway_Homo sapiens_hsa033200.76934156
69Sphingolipid metabolism_Homo sapiens_hsa006000.76783904
70Prostate cancer_Homo sapiens_hsa052150.75144646
71HTLV-I infection_Homo sapiens_hsa051660.74590357
72Fatty acid metabolism_Homo sapiens_hsa012120.72960276
73Phenylalanine metabolism_Homo sapiens_hsa003600.71128668
74HIF-1 signaling pathway_Homo sapiens_hsa040660.70893373
75Dorso-ventral axis formation_Homo sapiens_hsa043200.69856432
76Thyroid cancer_Homo sapiens_hsa052160.69640258
77Endometrial cancer_Homo sapiens_hsa052130.68776768
78Renal cell carcinoma_Homo sapiens_hsa052110.68063461
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66768167
80TNF signaling pathway_Homo sapiens_hsa046680.64877845
81Pancreatic cancer_Homo sapiens_hsa052120.64634148
82Estrogen signaling pathway_Homo sapiens_hsa049150.64232473
83Apoptosis_Homo sapiens_hsa042100.64137453
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64020025
85Hepatitis B_Homo sapiens_hsa051610.62828494
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.62801254
87Insulin signaling pathway_Homo sapiens_hsa049100.62214974
88Ras signaling pathway_Homo sapiens_hsa040140.60635762
89Galactose metabolism_Homo sapiens_hsa000520.59293293
90mTOR signaling pathway_Homo sapiens_hsa041500.58785989
91Shigellosis_Homo sapiens_hsa051310.57658123
92Renin-angiotensin system_Homo sapiens_hsa046140.55868382
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55721305
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55404249
95AMPK signaling pathway_Homo sapiens_hsa041520.55179798
96MAPK signaling pathway_Homo sapiens_hsa040100.51838647
97Gap junction_Homo sapiens_hsa045400.51129734
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49819772
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49719788
100Arginine and proline metabolism_Homo sapiens_hsa003300.49375338
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49129173
102Lysine degradation_Homo sapiens_hsa003100.48385281
103Lysosome_Homo sapiens_hsa041420.47425837
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47307908
105Prolactin signaling pathway_Homo sapiens_hsa049170.46845203
106Non-small cell lung cancer_Homo sapiens_hsa052230.46835780
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46238437
108Carbon metabolism_Homo sapiens_hsa012000.44854772
109Phagosome_Homo sapiens_hsa041450.44724975
110FoxO signaling pathway_Homo sapiens_hsa040680.43996849
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43239585
112Choline metabolism in cancer_Homo sapiens_hsa052310.43080771
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42515238
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.41355246
115Ether lipid metabolism_Homo sapiens_hsa005650.41303735
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41242546
117Hepatitis C_Homo sapiens_hsa051600.40749216
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39730264
119Salmonella infection_Homo sapiens_hsa051320.39296065
120Colorectal cancer_Homo sapiens_hsa052100.37041255
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36841177
122Rheumatoid arthritis_Homo sapiens_hsa053230.36154234
123Osteoclast differentiation_Homo sapiens_hsa043800.35971156
124Endocytosis_Homo sapiens_hsa041440.35915546
125Oxytocin signaling pathway_Homo sapiens_hsa049210.35233492
126Glucagon signaling pathway_Homo sapiens_hsa049220.34958591
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.34413372
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.33627330
129Propanoate metabolism_Homo sapiens_hsa006400.32058647

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