LRRC16A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of hormone metabolic process (GO:0032351)4.17168077
2negative regulation of hormone biosynthetic process (GO:0032353)4.17168077
3regulation of acrosome reaction (GO:0060046)4.08160451
4type B pancreatic cell development (GO:0003323)4.05910249
5water-soluble vitamin biosynthetic process (GO:0042364)3.85730369
6lactate metabolic process (GO:0006089)3.82069665
7regulation of glucokinase activity (GO:0033131)3.78899150
8regulation of hexokinase activity (GO:1903299)3.78899150
9positive regulation of glycoprotein biosynthetic process (GO:0010560)3.62533753
10regulation of meiosis I (GO:0060631)3.54669097
11cytoplasmic mRNA processing body assembly (GO:0033962)3.53016655
12keratinocyte development (GO:0003334)3.44789997
13regulation of steroid hormone biosynthetic process (GO:0090030)3.39436302
14positive regulation of catenin import into nucleus (GO:0035413)3.30782842
15intestinal epithelial cell development (GO:0060576)3.28606608
16respiratory chain complex IV assembly (GO:0008535)3.28578358
17retinal cone cell development (GO:0046549)3.28373036
18positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.28150224
19multicellular organism reproduction (GO:0032504)3.25765147
20piRNA metabolic process (GO:0034587)3.16181850
21myelination in peripheral nervous system (GO:0022011)3.12119098
22peripheral nervous system axon ensheathment (GO:0032292)3.12119098
23columnar/cuboidal epithelial cell development (GO:0002066)3.11971008
24notochord development (GO:0030903)3.11367937
25synapsis (GO:0007129)3.09836361
26protein K6-linked ubiquitination (GO:0085020)3.08851604
27positive regulation of protein autophosphorylation (GO:0031954)3.06499809
28prostate gland growth (GO:0060736)3.05898170
29presynaptic membrane assembly (GO:0097105)3.01163154
30myoblast migration (GO:0051451)2.99912436
31fucose catabolic process (GO:0019317)2.99109484
32L-fucose metabolic process (GO:0042354)2.99109484
33L-fucose catabolic process (GO:0042355)2.99109484
34negative regulation of sodium ion transport (GO:0010766)2.98333783
35negative regulation of osteoblast proliferation (GO:0033689)2.98002304
36response to pheromone (GO:0019236)2.95749551
37female gonad development (GO:0008585)2.91696968
38glandular epithelial cell development (GO:0002068)2.90161631
39regulation of cell maturation (GO:1903429)2.90002317
40inositol phosphate catabolic process (GO:0071545)2.86621891
41limb bud formation (GO:0060174)2.86029061
42negative regulation of DNA-dependent DNA replication (GO:2000104)2.85255188
43paraxial mesoderm development (GO:0048339)2.83255727
44regulation of transforming growth factor beta2 production (GO:0032909)2.82298109
45ovulation cycle (GO:0042698)2.82253490
46photoreceptor cell differentiation (GO:0046530)2.80807379
47eye photoreceptor cell differentiation (GO:0001754)2.80807379
48Sertoli cell development (GO:0060009)2.79968017
49regulation of meiosis (GO:0040020)2.77346585
50cytochrome complex assembly (GO:0017004)2.76545068
51positive regulation of meiosis (GO:0045836)2.74906666
52male genitalia development (GO:0030539)2.74406446
53positive regulation of glycoprotein metabolic process (GO:1903020)2.73082292
54negative regulation of keratinocyte proliferation (GO:0010839)2.70899985
55negative regulation of alcohol biosynthetic process (GO:1902931)2.69759268
56protein K11-linked deubiquitination (GO:0035871)2.68725761
57inositol phosphate dephosphorylation (GO:0046855)2.68217797
58phosphorylated carbohydrate dephosphorylation (GO:0046838)2.68217797
59regulation of hormone biosynthetic process (GO:0046885)2.66967006
60positive regulation of neurological system process (GO:0031646)2.66352195
61positive regulation of meiotic cell cycle (GO:0051446)2.66084677
62negative regulation of steroid biosynthetic process (GO:0010894)2.65685614
63DNA double-strand break processing (GO:0000729)2.64922759
64positive regulation of glycolytic process (GO:0045821)2.64608320
65regulation of mesoderm development (GO:2000380)2.64573362
66platelet dense granule organization (GO:0060155)2.63662333
67regulation of glucocorticoid metabolic process (GO:0031943)2.62913332
68meiotic cell cycle (GO:0051321)2.62828830
69positive regulation of hormone biosynthetic process (GO:0046886)2.62605204
70regulation of female gonad development (GO:2000194)2.61581830
71positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.61445504
72positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.61445504
73positive regulation of mitotic sister chromatid separation (GO:1901970)2.61445504
74replication fork processing (GO:0031297)2.59005915
75magnesium ion transport (GO:0015693)2.58935553
76iron ion import (GO:0097286)2.56169543
77regulation of phospholipid biosynthetic process (GO:0071071)2.54360542
78negative regulation of neurological system process (GO:0031645)2.53983933
79prenylation (GO:0097354)2.52950804
80protein prenylation (GO:0018342)2.52950804
81detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50959525
82positive regulation of DNA-dependent DNA replication (GO:2000105)2.50677822
83regulation of type B pancreatic cell apoptotic process (GO:2000674)2.50333104
84zinc ion transport (GO:0006829)2.50057784
85regulation of histone H3-K27 methylation (GO:0061085)2.49559424
86transepithelial transport (GO:0070633)2.49032928
87dorsal/ventral axis specification (GO:0009950)2.48313805
88hippo signaling (GO:0035329)2.47021784
89presynaptic membrane organization (GO:0097090)2.46637598
90regulation of protein glycosylation (GO:0060049)2.46302569
91aggressive behavior (GO:0002118)2.46087674
92polyol catabolic process (GO:0046174)2.45820339
93positive regulation of histone H3-K4 methylation (GO:0051571)2.45568447
94regulation of DNA methylation (GO:0044030)2.44693406
95oocyte development (GO:0048599)2.44278027
96branched-chain amino acid catabolic process (GO:0009083)2.41664028
97somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.41466778
98somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.41466778
99isotype switching (GO:0045190)2.41466778
100photoreceptor cell maintenance (GO:0045494)2.41109921
101regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.40579794
102pancreas development (GO:0031016)2.38412771
103RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.35963672
104negative regulation of steroid metabolic process (GO:0045939)2.35876764
105glycerophospholipid catabolic process (GO:0046475)2.35659320
106positive regulation of sodium ion transmembrane transport (GO:1902307)2.34979696
107genitalia morphogenesis (GO:0035112)2.34846400
108female gamete generation (GO:0007292)2.33942736
109tight junction assembly (GO:0070830)2.33771504
110regulation of mitotic spindle checkpoint (GO:1903504)2.33309765
111regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.33309765
112gland morphogenesis (GO:0022612)2.33263090
113endocrine pancreas development (GO:0031018)2.32865664
114cardiac right ventricle morphogenesis (GO:0003215)2.32769984
115embryonic camera-type eye morphogenesis (GO:0048596)2.32075091
116interkinetic nuclear migration (GO:0022027)2.31464414
117negative regulation of smooth muscle cell differentiation (GO:0051151)2.30391826
118regulation of cardioblast differentiation (GO:0051890)2.29378112
119somite rostral/caudal axis specification (GO:0032525)2.28950568
120epithelial cell maturation (GO:0002070)2.28146205
121regulation of meiotic cell cycle (GO:0051445)2.26990770
122male meiosis (GO:0007140)2.26130487
123organ formation (GO:0048645)2.24639713
124kidney morphogenesis (GO:0060993)2.24174057
125centrosome localization (GO:0051642)2.23860102
126negative regulation of transcription regulatory region DNA binding (GO:2000678)2.22813945
127cellular ketone body metabolic process (GO:0046950)2.22084035
128regulation of DNA endoreduplication (GO:0032875)2.21905827
129regulation of nuclear cell cycle DNA replication (GO:0033262)2.21740440
130parental behavior (GO:0060746)2.21601200
131double-strand break repair via homologous recombination (GO:0000724)2.21129365
132bundle of His cell to Purkinje myocyte communication (GO:0086069)2.20949029
133male meiosis I (GO:0007141)2.20738464
134lung-associated mesenchyme development (GO:0060484)2.20323138
135regulation of catenin import into nucleus (GO:0035412)2.20098729
136gamma-aminobutyric acid transport (GO:0015812)2.19679787
137DNA deamination (GO:0045006)2.19188450
138recombinational repair (GO:0000725)2.19132285
139axoneme assembly (GO:0035082)2.18703204
140positive regulation of chondrocyte differentiation (GO:0032332)2.18652535
141DNA damage induced protein phosphorylation (GO:0006975)2.18039142
142generation of neurons (GO:0048699)2.17957006
143embryonic foregut morphogenesis (GO:0048617)2.17898583
144positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.17845106
145ear development (GO:0043583)2.17809833
146lens fiber cell development (GO:0070307)2.17559472
147pharyngeal system development (GO:0060037)2.17297497
148relaxation of smooth muscle (GO:0044557)2.16670589
149regulation of calcium ion-dependent exocytosis (GO:0017158)2.15164715
150regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.14972081
151thyroid hormone metabolic process (GO:0042403)2.14864789
152retina layer formation (GO:0010842)2.14768230
153glial cell proliferation (GO:0014009)2.14761735
154negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.13568328
155protein complex biogenesis (GO:0070271)2.13478905
156DNA methylation involved in gamete generation (GO:0043046)2.13456396
157genitalia development (GO:0048806)2.13088499
158neuron fate determination (GO:0048664)2.12769389
159artery development (GO:0060840)2.12616845
160negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.11992549
161embryonic retina morphogenesis in camera-type eye (GO:0060059)2.11873180
162amino acid import (GO:0043090)2.11581532
163telomere maintenance via telomerase (GO:0007004)2.11539983
164hormone catabolic process (GO:0042447)2.11307760
165cilium morphogenesis (GO:0060271)2.10963021
166positive regulation of extracellular matrix organization (GO:1903055)2.10569666
167SMAD protein signal transduction (GO:0060395)2.09093778
168cellular response to hepatocyte growth factor stimulus (GO:0035729)2.08428300
169response to hepatocyte growth factor (GO:0035728)2.08428300
170positive regulation of cartilage development (GO:0061036)2.08261122
171positive regulation of Cdc42 GTPase activity (GO:0043089)2.07121981
172intestinal absorption (GO:0050892)2.07049449
173sphingosine metabolic process (GO:0006670)2.06468966
174positive regulation of male gonad development (GO:2000020)2.06414275
175histone H3-K4 trimethylation (GO:0080182)2.06327299
176inner ear receptor cell development (GO:0060119)2.05797520
177regulation of corticosteroid hormone secretion (GO:2000846)2.05591384
178positive regulation of hormone metabolic process (GO:0032352)2.04821227
179glomerulus development (GO:0032835)2.04491926
180negative regulation of stem cell proliferation (GO:2000647)2.03707638
181regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.03560855
182negative regulation of homotypic cell-cell adhesion (GO:0034111)2.03548983
183parturition (GO:0007567)2.01546480
184regulation of keratinocyte proliferation (GO:0010837)2.01097363
185L-amino acid import (GO:0043092)2.00942256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.92882240
2ZNF274_21170338_ChIP-Seq_K562_Hela2.40069963
3ZNF217_24962896_ChIP-Seq_MCF-7_Human2.38586351
4VDR_22108803_ChIP-Seq_LS180_Human2.36739631
5GBX2_23144817_ChIP-Seq_PC3_Human2.29279341
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.26452519
7EWS_26573619_Chip-Seq_HEK293_Human2.14311113
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09408065
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08855378
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.08263377
11SALL1_21062744_ChIP-ChIP_HESCs_Human1.97099151
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95092596
13* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.85751539
14TAF15_26573619_Chip-Seq_HEK293_Human1.84323461
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79976708
16PIAS1_25552417_ChIP-Seq_VCAP_Human1.78060456
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75276765
18IGF1R_20145208_ChIP-Seq_DFB_Human1.74010038
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71367459
20TP53_16413492_ChIP-PET_HCT116_Human1.70310445
21AR_21572438_ChIP-Seq_LNCaP_Human1.68304298
22AHR_22903824_ChIP-Seq_MCF-7_Human1.65472340
23* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64820295
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62037007
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60794770
26EZH2_22144423_ChIP-Seq_EOC_Human1.60006240
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59164511
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59164511
29ER_23166858_ChIP-Seq_MCF-7_Human1.58223713
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57495903
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53563992
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51562075
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.51471644
34TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.50899340
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.50645513
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.50546947
37* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49234108
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49139784
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.48284265
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45978380
41TCF4_22108803_ChIP-Seq_LS180_Human1.43221220
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41985938
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40002698
44CBP_20019798_ChIP-Seq_JUKART_Human1.40002698
45* STAT3_23295773_ChIP-Seq_U87_Human1.39975712
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.39827182
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.38183921
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37492345
49RXR_22108803_ChIP-Seq_LS180_Human1.37053271
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.36036340
51* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35918364
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34974357
53MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34826198
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34800868
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.34605748
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33414541
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33093962
58SMAD4_21799915_ChIP-Seq_A2780_Human1.32570110
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.32512891
60NANOG_19829295_ChIP-Seq_ESCs_Human1.30737665
61SOX2_19829295_ChIP-Seq_ESCs_Human1.30737665
62BCAT_22108803_ChIP-Seq_LS180_Human1.30248121
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29502218
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28900011
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.28790595
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.28356273
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27312197
68ELK1_19687146_ChIP-ChIP_HELA_Human1.25971734
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25801053
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.24448132
71* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24396531
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.24140074
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23528924
74TCF4_18268006_ChIP-ChIP_LS174T_Human1.22769978
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22501559
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.22255440
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.22239411
78* P300_19829295_ChIP-Seq_ESCs_Human1.22094191
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21603838
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21359903
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21261259
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20398902
83RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20256041
84P53_22387025_ChIP-Seq_ESCs_Mouse1.19450522
85* TCF4_23295773_ChIP-Seq_U87_Human1.19248167
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19180922
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.18129067
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17612258
89* CJUN_26792858_Chip-Seq_BT549_Human1.16969132
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16871046
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.16625445
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15967692
93RNF2_27304074_Chip-Seq_NSC_Mouse1.15927247
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15829642
95SMAD3_21741376_ChIP-Seq_HESCs_Human1.15720473
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15522190
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.15170450
98EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15079312
99RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15079312
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14209709
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.13807486
102CRX_20693478_ChIP-Seq_RETINA_Mouse1.13805470
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13745308
104* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13738800
105AR_19668381_ChIP-Seq_PC3_Human1.13204303
106FUS_26573619_Chip-Seq_HEK293_Human1.13014860
107TP53_22573176_ChIP-Seq_HFKS_Human1.12848759
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.12376960
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.12270824
110STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12238886
111SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11789804
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11628703
113ESR1_20079471_ChIP-ChIP_T-47D_Human1.10411092
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10137615
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10003913
116JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09957363
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09333057
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09035216
119RUNX2_22187159_ChIP-Seq_PCA_Human1.08544279
120TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08244419
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08182080
122TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07840578
123GABP_17652178_ChIP-ChIP_JURKAT_Human1.07796845
124BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07581283
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07453982
126CDX2_22108803_ChIP-Seq_LS180_Human1.06284402
127SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06197442
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06146606
129ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06040045
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06031980
131FOXA2_19822575_ChIP-Seq_HepG2_Human1.04981322
132AR_25329375_ChIP-Seq_VCAP_Human1.04852717
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04569107
134SOX2_21211035_ChIP-Seq_LN229_Gbm1.04543219
135* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04438207
136* FOXA1_25329375_ChIP-Seq_VCAP_Human1.04438207
137SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04267507
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04267339
139PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04121775
140SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03617104
141P300_18555785_Chip-Seq_ESCs_Mouse1.03611854
142CMYC_18555785_Chip-Seq_ESCs_Mouse1.03177687
143BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02652967
144DROSHA_22980978_ChIP-Seq_HELA_Human1.02063708
145TBL1_22424771_ChIP-Seq_293T_Human1.01794459
146FOXO3_23340844_ChIP-Seq_DLD1_Human1.01287846
147SMAD3_21741376_ChIP-Seq_ESCs_Human1.01129283
148E2F1_18555785_Chip-Seq_ESCs_Mouse1.00896423
149STAT3_18555785_Chip-Seq_ESCs_Mouse1.00592665
150TAL1_26923725_Chip-Seq_HPCs_Mouse1.00476439
151* FLI1_21867929_ChIP-Seq_TH2_Mouse1.00143798
152TP53_18474530_ChIP-ChIP_U2OS_Human1.00108797
153MYC_18940864_ChIP-ChIP_HL60_Human0.99409764
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.98384135
155HTT_18923047_ChIP-ChIP_STHdh_Human0.97705058

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.29567763
2MP0004264_abnormal_extraembryonic_tissu3.23554755
3MP0009384_cardiac_valve_regurgitation3.20400581
4MP0002653_abnormal_ependyma_morphology2.85502149
5MP0000462_abnormal_digestive_system2.77780088
6MP0005451_abnormal_body_composition2.63643647
7MP0000579_abnormal_nail_morphology2.31257237
8MP0002254_reproductive_system_inflammat2.30262420
9MP0003195_calcinosis2.13886245
10MP0003937_abnormal_limbs/digits/tail_de2.12236406
11MP0003283_abnormal_digestive_organ2.02267537
12MP0001984_abnormal_olfaction1.98423532
13MP0001346_abnormal_lacrimal_gland1.88878058
14MP0002938_white_spotting1.88535303
15MP0002102_abnormal_ear_morphology1.85417462
16MP0002249_abnormal_larynx_morphology1.84411760
17MP0002233_abnormal_nose_morphology1.83644993
18MP0009780_abnormal_chondrocyte_physiolo1.79677529
19MP0005551_abnormal_eye_electrophysiolog1.79205120
20MP0003787_abnormal_imprinting1.78105714
21MP0010234_abnormal_vibrissa_follicle1.77913906
22MP0002163_abnormal_gland_morphology1.77138288
23MP0002876_abnormal_thyroid_physiology1.75582718
24MP0001485_abnormal_pinna_reflex1.73874696
25MP0001299_abnormal_eye_distance/1.73511690
26MP0008789_abnormal_olfactory_epithelium1.73317234
27MP0003115_abnormal_respiratory_system1.66252955
28MP0005379_endocrine/exocrine_gland_phen1.61393537
29MP0002098_abnormal_vibrissa_morphology1.60084250
30MP0002837_dystrophic_cardiac_calcinosis1.58892545
31MP0003868_abnormal_feces_composition1.56152516
32MP0000432_abnormal_head_morphology1.55684398
33MP0009250_abnormal_appendicular_skeleto1.54578539
34MP0008877_abnormal_DNA_methylation1.53471945
35MP0005367_renal/urinary_system_phenotyp1.51995865
36MP0010678_abnormal_skin_adnexa1.51769348
37MP0010352_gastrointestinal_tract_polyps1.49938823
38MP0005377_hearing/vestibular/ear_phenot1.49894441
39MP0003878_abnormal_ear_physiology1.49894441
40MP0003755_abnormal_palate_morphology1.49159287
41MP0002116_abnormal_craniofacial_bone1.48143258
42MP0002138_abnormal_hepatobiliary_system1.46787600
43MP0004043_abnormal_pH_regulation1.46401447
44MP0008058_abnormal_DNA_repair1.45806563
45MP0004885_abnormal_endolymph1.44596925
46MP0005408_hypopigmentation1.41199153
47MP0001177_atelectasis1.41103986
48MP0000569_abnormal_digit_pigmentation1.40761274
49MP0002234_abnormal_pharynx_morphology1.39099845
50MP0000383_abnormal_hair_follicle1.39076147
51MP0001502_abnormal_circadian_rhythm1.37761246
52MP0002295_abnormal_pulmonary_circulatio1.35510352
53MP0002736_abnormal_nociception_after1.33109403
54MP0005253_abnormal_eye_physiology1.32767915
55MP0008872_abnormal_physiological_respon1.31743959
56MP0008057_abnormal_DNA_replication1.30838199
57MP0006292_abnormal_olfactory_placode1.29343475
58MP0005248_abnormal_Harderian_gland1.29307896
59MP0003935_abnormal_craniofacial_develop1.28321246
60MP0002751_abnormal_autonomic_nervous1.28084938
61MP0000049_abnormal_middle_ear1.27772643
62MP0002160_abnormal_reproductive_system1.26318359
63MP0005310_abnormal_salivary_gland1.26174268
64MP0003121_genomic_imprinting1.25593766
65MP0002168_other_aberrant_phenotype1.25170324
66MP0005220_abnormal_exocrine_pancreas1.23007362
67MP0005395_other_phenotype1.21895733
68MP0003718_maternal_effect1.19337452
69MP0000678_abnormal_parathyroid_gland1.19199563
70MP0003942_abnormal_urinary_system1.18309130
71MP0006072_abnormal_retinal_apoptosis1.16875882
72MP0000631_abnormal_neuroendocrine_gland1.16784851
73MP0005174_abnormal_tail_pigmentation1.16244824
74MP0002909_abnormal_adrenal_gland1.15867653
75MP0005499_abnormal_olfactory_system1.15794597
76MP0005394_taste/olfaction_phenotype1.15794597
77MP0000372_irregular_coat_pigmentation1.14763231
78MP0004270_analgesia1.14578175
79MP0000534_abnormal_ureter_morphology1.14421851
80MP0000613_abnormal_salivary_gland1.14388671
81MP0000762_abnormal_tongue_morphology1.11257276
82MP0000427_abnormal_hair_cycle1.10801320
83MP0005257_abnormal_intraocular_pressure1.10775260
84MP0004019_abnormal_vitamin_homeostasis1.09372180
85MP0005389_reproductive_system_phenotype1.08551262
86MP0000647_abnormal_sebaceous_gland1.07832151
87MP0002638_abnormal_pupillary_reflex1.07158988
88MP0002090_abnormal_vision1.05964034
89MP0003045_fibrosis1.05658108
90MP0000537_abnormal_urethra_morphology1.04999091
91MP0001944_abnormal_pancreas_morphology1.04528782
92MP0001119_abnormal_female_reproductive1.04526366
93MP0004272_abnormal_basement_membrane1.04348664
94MP0005075_abnormal_melanosome_morpholog1.04179157
95MP0002928_abnormal_bile_duct1.04168785
96MP0010094_abnormal_chromosome_stability1.03845776
97MP0009046_muscle_twitch1.03640190
98MP0010030_abnormal_orbit_morphology1.02969467
99MP0005646_abnormal_pituitary_gland1.02942669
100MP0004858_abnormal_nervous_system1.02919704
101MP0000778_abnormal_nervous_system1.02684936
102MP0003699_abnormal_female_reproductive1.02446681
103MP0002272_abnormal_nervous_system1.02438521
104MP0005332_abnormal_amino_acid1.01648723
105MP0008875_abnormal_xenobiotic_pharmacok1.01598314
106MP0005187_abnormal_penis_morphology1.00800663
107MP0003385_abnormal_body_wall1.00709927
108MP0003786_premature_aging0.99426541
109MP0001293_anophthalmia0.97913192
110MP0005085_abnormal_gallbladder_physiolo0.96405519
111MP0002177_abnormal_outer_ear0.96159673
112MP0005670_abnormal_white_adipose0.95985332
113MP0001666_abnormal_nutrient_absorption0.95799736
114MP0000163_abnormal_cartilage_morphology0.95727491
115MP0003890_abnormal_embryonic-extraembry0.93960392
116MP0003136_yellow_coat_color0.93465412
117MP0002089_abnormal_postnatal_growth/wei0.92501432
118MP0005410_abnormal_fertilization0.92107858
119MP0005508_abnormal_skeleton_morphology0.91343764
120MP0001286_abnormal_eye_development0.91268079
121MP0003693_abnormal_embryo_hatching0.91229604
122MP0002009_preneoplasia0.91175103
123MP0000538_abnormal_urinary_bladder0.90489604
124MP0003183_abnormal_peptide_metabolism0.89963328
125MP0005645_abnormal_hypothalamus_physiol0.89647034
126MP0001968_abnormal_touch/_nociception0.89578603
127MP0009703_decreased_birth_body0.88968069
128MP0002109_abnormal_limb_morphology0.88769197
129MP0010307_abnormal_tumor_latency0.88601954
130MP0003252_abnormal_bile_duct0.88539747
131MP0002210_abnormal_sex_determination0.88335686
132MP0003123_paternal_imprinting0.87759544
133MP0002139_abnormal_hepatobiliary_system0.87407321
134MP0003941_abnormal_skin_development0.86507600
135MP0005647_abnormal_sex_gland0.86387053
136MP0000653_abnormal_sex_gland0.86343716
137MP0002092_abnormal_eye_morphology0.84579143
138MP0002282_abnormal_trachea_morphology0.84002861
139MP0001963_abnormal_hearing_physiology0.83733076
140MP0002896_abnormal_bone_mineralization0.83660959
141MP0003861_abnormal_nervous_system0.83649731
142MP0003936_abnormal_reproductive_system0.83646872
143MP0003119_abnormal_digestive_system0.83086398
144MP0009697_abnormal_copulation0.82895127
145MP0000428_abnormal_craniofacial_morphol0.82823245
146MP0003632_abnormal_nervous_system0.81893518
147MP0004215_abnormal_myocardial_fiber0.81837301
148MP0001756_abnormal_urination0.81595308
149MP0006054_spinal_hemorrhage0.81498705
150MP0009745_abnormal_behavioral_response0.80945235
151MP0001915_intracranial_hemorrhage0.80625409
152MP0002796_impaired_skin_barrier0.80284890
153MP0001929_abnormal_gametogenesis0.79587351
154MP0000516_abnormal_urinary_system0.79140959
155MP0001145_abnormal_male_reproductive0.78919006
156MP0001986_abnormal_taste_sensitivity0.78664606
157MP0004147_increased_porphyrin_level0.78614597
158MP0002557_abnormal_social/conspecific_i0.77540352
159MP0001486_abnormal_startle_reflex0.76740695
160MP0008775_abnormal_heart_ventricle0.76611080
161MP0010329_abnormal_lipoprotein_level0.76379623
162MP0005360_urolithiasis0.76346091

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the extremities (HP:0009825)3.05602260
2Aplasia involving bones of the upper limbs (HP:0009823)3.05602260
3Aplasia of the phalanges of the hand (HP:0009802)3.05602260
4Lip pit (HP:0100267)2.96428720
5Male infertility (HP:0003251)2.94180287
6Pancreatic cysts (HP:0001737)2.90527966
7Neoplasm of the adrenal cortex (HP:0100641)2.86918125
8Papillary thyroid carcinoma (HP:0002895)2.85390813
9Hypothermia (HP:0002045)2.85015485
10Abnormality of the labia minora (HP:0012880)2.77308171
11Hypoplasia of the fovea (HP:0007750)2.74989802
12Aplasia/Hypoplasia of the fovea (HP:0008060)2.74989802
13Pancreatic fibrosis (HP:0100732)2.74029901
14Follicular hyperkeratosis (HP:0007502)2.72915154
15Abnormality of the renal cortex (HP:0011035)2.71693135
16Methylmalonic acidemia (HP:0002912)2.60048756
17Midline defect of the nose (HP:0004122)2.58397148
18Intestinal atresia (HP:0011100)2.57209318
19Abnormality of midbrain morphology (HP:0002418)2.53788123
20Molar tooth sign on MRI (HP:0002419)2.53788123
21Oligodactyly (hands) (HP:0001180)2.50943096
22Aqueductal stenosis (HP:0002410)2.49226865
23Hypoglycemic coma (HP:0001325)2.49175537
24Medial flaring of the eyebrow (HP:0010747)2.48269171
25True hermaphroditism (HP:0010459)2.47975735
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.47273188
27Aplasia/Hypoplasia of the tibia (HP:0005772)2.44599576
28Short tibia (HP:0005736)2.42177605
29Facial shape deformation (HP:0011334)2.39996606
30Potter facies (HP:0002009)2.39996606
31Congenital sensorineural hearing impairment (HP:0008527)2.36748543
32Flat capital femoral epiphysis (HP:0003370)2.36482203
33Abnormality of vitamin B metabolism (HP:0004340)2.36372027
34Adrenal hypoplasia (HP:0000835)2.33211194
35Abnormality of incisor morphology (HP:0011063)2.30231380
36Abnormality of the fovea (HP:0000493)2.28321752
37Nephronophthisis (HP:0000090)2.27556763
38Gaze-evoked nystagmus (HP:0000640)2.26655423
39Renal cortical cysts (HP:0000803)2.22379545
40Enlarged penis (HP:0000040)2.21304606
41Hypoglycemic seizures (HP:0002173)2.21076553
42Widely patent fontanelles and sutures (HP:0004492)2.19164829
43Absent frontal sinuses (HP:0002688)2.18505661
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17079283
45Shawl scrotum (HP:0000049)2.16385532
46Abnormality of the renal medulla (HP:0100957)2.16212233
47Hyperinsulinemic hypoglycemia (HP:0000825)2.14522293
48Ketoacidosis (HP:0001993)2.13796140
49Genital tract atresia (HP:0001827)2.12035088
50Abnormality of the astrocytes (HP:0100707)2.11383030
51Astrocytoma (HP:0009592)2.11383030
52Oligodactyly (HP:0012165)2.10494191
53Abnormal pancreas size (HP:0012094)2.09508442
54Glioma (HP:0009733)2.07169151
55Tubular atrophy (HP:0000092)2.05807824
56Large for gestational age (HP:0001520)2.05580216
57Abnormality of the vitamin B12 metabolism (HP:0004341)2.04014405
58Methylmalonic aciduria (HP:0012120)2.03692554
59Breast carcinoma (HP:0003002)2.03044126
60Hypomagnesemia (HP:0002917)2.03039411
61Congenital stationary night blindness (HP:0007642)2.02419816
62Disproportionate short-trunk short stature (HP:0003521)2.01628890
63Hamartoma of the eye (HP:0010568)2.01160500
64Abolished electroretinogram (ERG) (HP:0000550)2.00891400
65Chronic bronchitis (HP:0004469)1.99638768
66Thyroiditis (HP:0100646)1.99119940
67Chromsome breakage (HP:0040012)1.99043090
68Hypoplasia of the uterus (HP:0000013)1.97693810
69Abnormality of chromosome stability (HP:0003220)1.97540410
70Aplasia/Hypoplasia of the tongue (HP:0010295)1.96379465
71Progressive macrocephaly (HP:0004481)1.95398989
72Median cleft lip (HP:0000161)1.93746283
73Neonatal short-limb short stature (HP:0008921)1.93645551
74Abnormality of the ischium (HP:0003174)1.93023955
75Abnormality of the proximal phalanges of the hand (HP:0009834)1.92706429
76Bifid tongue (HP:0010297)1.92534048
77Alopecia of scalp (HP:0002293)1.91967332
78Neoplasm of the adrenal gland (HP:0100631)1.91911809
79Abnormality of the distal phalanx of the thumb (HP:0009617)1.91840005
80Vaginal atresia (HP:0000148)1.91441471
81Aplasia/hypoplasia of the uterus (HP:0008684)1.90678381
82Hypoplastic ischia (HP:0003175)1.87471351
83Hyperventilation (HP:0002883)1.86092405
84Ependymoma (HP:0002888)1.84960207
85Congenital primary aphakia (HP:0007707)1.84638579
86Stenosis of the external auditory canal (HP:0000402)1.84377061
87Onycholysis (HP:0001806)1.84077009
88Colon cancer (HP:0003003)1.83937708
89Supernumerary spleens (HP:0009799)1.83796170
90Hyperglycinemia (HP:0002154)1.83751038
91Gastrointestinal atresia (HP:0002589)1.83457825
92Decreased circulating renin level (HP:0003351)1.83249779
93Abnormality of the nasal septum (HP:0000419)1.82288651
94Mixed hearing impairment (HP:0000410)1.81521606
95Abnormality of the 1st metacarpal (HP:0010009)1.81409534
96Trigonocephaly (HP:0000243)1.81243925
97Hypoplasia of the ulna (HP:0003022)1.80910560
98Hypoplastic nipples (HP:0002557)1.80088904
99Synostosis of carpal bones (HP:0005048)1.79538174
100Arterial tortuosity (HP:0005116)1.78720030
101Renal dysplasia (HP:0000110)1.78677969
102Gait imbalance (HP:0002141)1.78438380
103Aplasia/Hypoplasia of the uvula (HP:0010293)1.78091429
104Hypoplastic labia majora (HP:0000059)1.77717878
105Pendular nystagmus (HP:0012043)1.77346033
106Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76190391
107Furrowed tongue (HP:0000221)1.75375464
108Short 1st metacarpal (HP:0010034)1.75292319
109Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.75292319
110Abnormal biliary tract morphology (HP:0012440)1.74388875
111Aplasia/Hypoplasia of the ulna (HP:0006495)1.72687888
112Chronic hepatic failure (HP:0100626)1.72480354
113Aplasia/Hypoplasia of the hallux (HP:0008362)1.71813391
114Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71471330
115Ketosis (HP:0001946)1.70948990
116Small epiphyses (HP:0010585)1.70815661
117Tongue fasciculations (HP:0001308)1.70268455
118Abnormality of vitamin metabolism (HP:0100508)1.70008903
119Curly hair (HP:0002212)1.69610043
120Blepharitis (HP:0000498)1.69533429
121Attenuation of retinal blood vessels (HP:0007843)1.69512924
122Facial hemangioma (HP:0000329)1.69072546
123Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69013567
124Nephrogenic diabetes insipidus (HP:0009806)1.68191057
125Bilateral microphthalmos (HP:0007633)1.67476018
126Abnormality of the pons (HP:0007361)1.66764037
127Cubitus valgus (HP:0002967)1.66646273
128Epiphyseal dysplasia (HP:0002656)1.66526443
129Hemiparesis (HP:0001269)1.66496326
130Abnormality of the phalanges of the hallux (HP:0010057)1.65911917
131Abnormality of glycine metabolism (HP:0010895)1.65663855
132Abnormality of serine family amino acid metabolism (HP:0010894)1.65663855
133Labial hypoplasia (HP:0000066)1.65326400
134Abnormal respiratory motile cilium physiology (HP:0012261)1.65287865
135Preaxial hand polydactyly (HP:0001177)1.65213505
136Shallow orbits (HP:0000586)1.65194001
137Absent thumb (HP:0009777)1.64565626
138Acute necrotizing encephalopathy (HP:0006965)1.64079902
139Optic nerve hypoplasia (HP:0000609)1.64046485
140Sandal gap (HP:0001852)1.63750627
141Abnormal drinking behavior (HP:0030082)1.63636610
142Polydipsia (HP:0001959)1.63636610
143Short middle phalanx of finger (HP:0005819)1.63568360
144Vascular tortuosity (HP:0004948)1.63370057
145Bicornuate uterus (HP:0000813)1.63096924
146Aplasia/Hypoplasia of the scapulae (HP:0006713)1.62661229
147Hypoplastic scapulae (HP:0000882)1.62661229
148Proximal tubulopathy (HP:0000114)1.62445852
149Occipital encephalocele (HP:0002085)1.62348668
150Abnormality of the labia majora (HP:0012881)1.62321312
151Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.62194319
152Laryngomalacia (HP:0001601)1.62179830
153Vitreoretinal degeneration (HP:0000655)1.62012747
154Posterior subcapsular cataract (HP:0007787)1.61987564
155Short nail (HP:0001799)1.60487256
156Increased number of teeth (HP:0011069)1.58504873
157Hypoplasia of dental enamel (HP:0006297)1.57930252
158Microglossia (HP:0000171)1.57663889
159Bifid scrotum (HP:0000048)1.56348759
160Short phalanx of the thumb (HP:0009660)1.55746525
161Hypoplastic iliac wings (HP:0002866)1.55644357
162Cupped ear (HP:0000378)1.55132915
163Tibial bowing (HP:0002982)1.54992394
164Pili torti (HP:0003777)1.54306955
165Abnormality of the middle phalanges of the toes (HP:0010183)1.53967526
166Milia (HP:0001056)1.53204050
167Abnormality of the intervertebral disk (HP:0005108)1.52762641
168Abnormality of cochlea (HP:0000375)1.50660815
169Abnormal vertebral ossification (HP:0100569)1.50437208
170Abnormality of chromosome segregation (HP:0002916)1.50277880
171Anal stenosis (HP:0002025)1.50147034
172Hyperglycemia (HP:0003074)1.49338546
173Neoplasm of the tracheobronchial system (HP:0100552)1.48206640
174Abnormality of the incisor (HP:0000676)1.47846326
175Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.46459385
176Abnormality of the lacrimal duct (HP:0011481)1.45958219
177Cystic liver disease (HP:0006706)1.44621372
178Abnormality of the nasolacrimal system (HP:0000614)1.44619467
179Abnormality of the phalanges of the 2nd finger (HP:0009541)1.43751436
180Abnormality of the fingertips (HP:0001211)1.43081534
181Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.42480331
182Abnormality of the pubic bones (HP:0003172)1.42276231
183Leiomyosarcoma (HP:0100243)1.42100086
184Uterine leiomyosarcoma (HP:0002891)1.42100086
185Urethral obstruction (HP:0000796)1.41640835
186Abnormality of the parathyroid morphology (HP:0011766)1.41635795
187Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.41409093
188Abnormality of the axillary hair (HP:0100134)1.41292751
189Abnormality of secondary sexual hair (HP:0009888)1.41292751
190Amelogenesis imperfecta (HP:0000705)1.41064611
191Short hallux (HP:0010109)1.40732003
192Tubulointerstitial nephritis (HP:0001970)1.40226342
193Insulin-resistant diabetes mellitus (HP:0000831)1.39483732
194Abnormality of the middle phalanges of the hand (HP:0009833)1.38887619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.05698067
2LATS14.33060044
3MKNK23.12110727
4TRIM282.58633854
5ACVR1B2.58131609
6AKT32.48250767
7MAP4K22.43931025
8EIF2AK32.38268232
9STK38L2.31640445
10FGFR22.29365102
11GRK12.15057319
12BMPR22.10847199
13MAPK132.09498705
14LATS22.09161763
15EPHA21.89700571
16ERBB41.88687702
17BRAF1.87407870
18STK31.86014313
19TTK1.82234953
20FRK1.77208928
21NUAK11.74058601
22INSRR1.71198376
23MAP3K61.66343376
24MKNK11.62753815
25PLK31.59740143
26SGK21.59673578
27EEF2K1.52578823
28MAP3K91.50371232
29SGK31.42040866
30CSNK1G11.41689862
31LMTK21.39759501
32TAOK31.38680222
33TAOK11.36958883
34PINK11.36362746
35SIK11.36226556
36EIF2AK11.28748544
37CDK91.26405189
38ADRBK21.25981162
39CAMK1G1.24805547
40PRKD31.23569135
41MAPK151.23149311
42DMPK1.20029191
43NEK61.18161946
44PLK41.15693197
45KSR21.14523449
46MARK21.13431140
47CSNK1G31.10984676
48CSNK1G21.09826265
49BRSK21.09499536
50SGK2231.07645948
51SGK4941.07645948
52PRKAA21.06186475
53PAK31.05781912
54RPS6KB21.00468351
55CDK120.99122361
56PRKD20.99095810
57TLK10.93109170
58CSNK1A1L0.92556453
59NTRK20.90408565
60ROCK10.88046976
61PNCK0.88030580
62STK100.87832682
63PTK20.86664282
64PHKG10.85697269
65PHKG20.85697269
66MAP2K20.85187487
67BCR0.82719795
68CDC70.81100760
69TSSK60.80834903
70MAP3K20.80314821
71STK390.79796430
72CDK30.79371542
73CHEK20.79159013
74PLK10.77533685
75PIK3CA0.76251057
76PRKAA10.74085820
77MAPKAPK30.73915008
78STK240.73401683
79MAP3K120.72833207
80PKN10.72226657
81PRKCI0.70581642
82CAMK1D0.70272629
83EPHB20.69628941
84DYRK1A0.69616873
85KSR10.68273287
86EIF2AK20.67044730
87MUSK0.66282047
88TGFBR10.65545313
89DDR20.65470506
90PBK0.65410737
91VRK10.64598085
92CHUK0.63883622
93MET0.62528816
94ERBB30.61237074
95BUB10.60215097
96MAP3K130.60204380
97VRK20.59672158
98TAF10.56964814
99MAP2K10.56933097
100TYRO30.56866091
101MST40.56662733
102WNK30.56262154
103MAP3K40.56026766
104FGR0.55230857
105CASK0.55037664
106MELK0.53999548
107MAP2K70.51980571
108STK160.51101753
109MAPKAPK50.49940205
110PRKCG0.49517173
111PLK20.49474372
112PAK60.45519264
113NTRK30.45260617
114PDK20.44816346
115CDC42BPA0.44205156
116CSNK1A10.43509334
117SGK10.42465601
118MST1R0.42409449
119CSNK1D0.42127497
120RIPK10.41778672
121PRKCE0.41681411
122FER0.40431373
123CAMK2A0.40136157
124WNK40.39472419
125FLT30.39063481
126TIE10.38961356
127WEE10.38533710
128FGFR10.38430604
129CAMK2D0.37851366
130DAPK20.37765212
131PTK2B0.37551281
132NLK0.37113324
133TRPM70.36498081
134MTOR0.35704175
135SRPK10.35153041
136NEK10.34546411
137MAP3K80.34405378
138ADRBK10.33773374
139BMPR1B0.33553782
140OXSR10.33405714
141AURKA0.33300221
142PTK60.32744722
143GSK3B0.30992679
144ATM0.30408397
145ZAK0.29802109
146PRKACA0.28959034
147EPHA40.28731325
148CSNK1E0.27822834
149BCKDK0.27822099
150ATR0.27511161
151PRKG10.27196334

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002322.46399303
2Protein export_Homo sapiens_hsa030602.38182548
3Ovarian steroidogenesis_Homo sapiens_hsa049132.19187998
4Propanoate metabolism_Homo sapiens_hsa006402.03065515
5Basal transcription factors_Homo sapiens_hsa030222.00659611
6Circadian rhythm_Homo sapiens_hsa047101.99446081
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98657471
8Maturity onset diabetes of the young_Homo sapiens_hsa049501.98627981
9Vitamin B6 metabolism_Homo sapiens_hsa007501.97504870
10Nitrogen metabolism_Homo sapiens_hsa009101.97288679
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96421828
12Adherens junction_Homo sapiens_hsa045201.95120901
13Fatty acid biosynthesis_Homo sapiens_hsa000611.91213163
14Non-homologous end-joining_Homo sapiens_hsa034501.88856284
15Butanoate metabolism_Homo sapiens_hsa006501.81226302
16TGF-beta signaling pathway_Homo sapiens_hsa043501.77569214
17Hippo signaling pathway_Homo sapiens_hsa043901.76230249
18Homologous recombination_Homo sapiens_hsa034401.76010186
19Phototransduction_Homo sapiens_hsa047441.61252526
20Basal cell carcinoma_Homo sapiens_hsa052171.61182273
21Selenocompound metabolism_Homo sapiens_hsa004501.60233813
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56957185
23Hedgehog signaling pathway_Homo sapiens_hsa043401.56738518
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54744394
25Sulfur metabolism_Homo sapiens_hsa009201.52589341
26Protein digestion and absorption_Homo sapiens_hsa049741.51665522
27Dorso-ventral axis formation_Homo sapiens_hsa043201.50699622
28Fanconi anemia pathway_Homo sapiens_hsa034601.50417001
29Lysine degradation_Homo sapiens_hsa003101.47006879
30ECM-receptor interaction_Homo sapiens_hsa045121.45873630
31Fatty acid elongation_Homo sapiens_hsa000621.45683863
32Ether lipid metabolism_Homo sapiens_hsa005651.45208961
33RNA degradation_Homo sapiens_hsa030181.44775453
34Endometrial cancer_Homo sapiens_hsa052131.41378001
35Mismatch repair_Homo sapiens_hsa034301.40777880
36Prostate cancer_Homo sapiens_hsa052151.35784666
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32764984
38Mineral absorption_Homo sapiens_hsa049781.32072222
39MicroRNAs in cancer_Homo sapiens_hsa052061.31835971
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30702508
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.25672711
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24857258
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23355909
44Tight junction_Homo sapiens_hsa045301.23189945
45Retinol metabolism_Homo sapiens_hsa008301.20974051
46Pancreatic cancer_Homo sapiens_hsa052121.19380851
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18984164
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18153426
49Peroxisome_Homo sapiens_hsa041461.17696547
50GnRH signaling pathway_Homo sapiens_hsa049121.17318918
51Chemical carcinogenesis_Homo sapiens_hsa052041.16846160
52Choline metabolism in cancer_Homo sapiens_hsa052311.14673694
53Steroid biosynthesis_Homo sapiens_hsa001001.14279639
54RNA polymerase_Homo sapiens_hsa030201.13763043
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13348483
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12862290
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12150342
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11293012
59Proteasome_Homo sapiens_hsa030501.09088073
60Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07522009
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04841895
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03334084
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03232183
64Nicotine addiction_Homo sapiens_hsa050331.03021995
65Sphingolipid metabolism_Homo sapiens_hsa006001.02978243
66Folate biosynthesis_Homo sapiens_hsa007901.02927780
67Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02477837
68Axon guidance_Homo sapiens_hsa043601.01959284
69Bile secretion_Homo sapiens_hsa049761.01679526
70Insulin secretion_Homo sapiens_hsa049111.00736397
71Notch signaling pathway_Homo sapiens_hsa043301.00289896
72Wnt signaling pathway_Homo sapiens_hsa043100.99235832
73Small cell lung cancer_Homo sapiens_hsa052220.97585189
74beta-Alanine metabolism_Homo sapiens_hsa004100.97523294
75Vitamin digestion and absorption_Homo sapiens_hsa049770.95950637
76Inositol phosphate metabolism_Homo sapiens_hsa005620.94225539
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93664051
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93139094
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92735783
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90756426
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90086563
82Oxidative phosphorylation_Homo sapiens_hsa001900.89743770
83ErbB signaling pathway_Homo sapiens_hsa040120.89651826
84Focal adhesion_Homo sapiens_hsa045100.88663697
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.87398397
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87201923
87Nucleotide excision repair_Homo sapiens_hsa034200.85366578
88Long-term depression_Homo sapiens_hsa047300.83168346
89Proteoglycans in cancer_Homo sapiens_hsa052050.82235025
90ABC transporters_Homo sapiens_hsa020100.82120971
91Glutamatergic synapse_Homo sapiens_hsa047240.82002524
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80925363
93Melanogenesis_Homo sapiens_hsa049160.79410310
94Linoleic acid metabolism_Homo sapiens_hsa005910.79035177
95Pancreatic secretion_Homo sapiens_hsa049720.78570997
96Thyroid hormone synthesis_Homo sapiens_hsa049180.78227883
97Melanoma_Homo sapiens_hsa052180.76929633
98Estrogen signaling pathway_Homo sapiens_hsa049150.76447431
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.76243296
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.76234774
101Histidine metabolism_Homo sapiens_hsa003400.75613687
102One carbon pool by folate_Homo sapiens_hsa006700.75216370
103Colorectal cancer_Homo sapiens_hsa052100.75199717
104Fat digestion and absorption_Homo sapiens_hsa049750.73897873
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73344511
106Prolactin signaling pathway_Homo sapiens_hsa049170.72221811
107Glutathione metabolism_Homo sapiens_hsa004800.70353660
108Thyroid cancer_Homo sapiens_hsa052160.69309699
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69170083
110Regulation of autophagy_Homo sapiens_hsa041400.69044384
111Purine metabolism_Homo sapiens_hsa002300.68903723
112Arachidonic acid metabolism_Homo sapiens_hsa005900.68871449
113Olfactory transduction_Homo sapiens_hsa047400.67897646
114Metabolic pathways_Homo sapiens_hsa011000.66338239
115cAMP signaling pathway_Homo sapiens_hsa040240.66170881
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65703761
117Arginine and proline metabolism_Homo sapiens_hsa003300.65305980
118RNA transport_Homo sapiens_hsa030130.64915339
119Type II diabetes mellitus_Homo sapiens_hsa049300.63683159
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62427262
121Long-term potentiation_Homo sapiens_hsa047200.61834141
122Renin-angiotensin system_Homo sapiens_hsa046140.61170614
123Glioma_Homo sapiens_hsa052140.60852649
124Pyruvate metabolism_Homo sapiens_hsa006200.60337568
125Starch and sucrose metabolism_Homo sapiens_hsa005000.59583867
126Bladder cancer_Homo sapiens_hsa052190.59484397
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.59414191
128Salivary secretion_Homo sapiens_hsa049700.58772245
129Tryptophan metabolism_Homo sapiens_hsa003800.58659881
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.58193099
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57800102
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57595476
133Gastric acid secretion_Homo sapiens_hsa049710.56888329
134Renal cell carcinoma_Homo sapiens_hsa052110.56308731
135Pathways in cancer_Homo sapiens_hsa052000.54558496
136Cell cycle_Homo sapiens_hsa041100.54520190
137Serotonergic synapse_Homo sapiens_hsa047260.54332047
138Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54127117
139Glycerolipid metabolism_Homo sapiens_hsa005610.53260747
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51978322
141Ras signaling pathway_Homo sapiens_hsa040140.51543858
142Parkinsons disease_Homo sapiens_hsa050120.51057326
143PPAR signaling pathway_Homo sapiens_hsa033200.50491593
144p53 signaling pathway_Homo sapiens_hsa041150.50334718
145Cholinergic synapse_Homo sapiens_hsa047250.50055641
146Gap junction_Homo sapiens_hsa045400.49566288
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49238559
148GABAergic synapse_Homo sapiens_hsa047270.48921651
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.48799032
150Fatty acid degradation_Homo sapiens_hsa000710.48336657
151Amoebiasis_Homo sapiens_hsa051460.48148089
152Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48063864
153Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46399082
154Drug metabolism - other enzymes_Homo sapiens_hsa009830.46182391
155Fatty acid metabolism_Homo sapiens_hsa012120.45795249
156Oocyte meiosis_Homo sapiens_hsa041140.45232198
157Renin secretion_Homo sapiens_hsa049240.44137866
158Circadian entrainment_Homo sapiens_hsa047130.43548655
159FoxO signaling pathway_Homo sapiens_hsa040680.42225939
160cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41473857
161Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41037488
162Taste transduction_Homo sapiens_hsa047420.40709087
163Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39297459

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