LRRC17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)6.57801860
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.10769690
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.88991861
4protein localization to synapse (GO:0035418)5.76178019
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.72055269
6muscle cell fate commitment (GO:0042693)5.59669672
7regulation of short-term neuronal synaptic plasticity (GO:0048172)5.59624708
8presynaptic membrane assembly (GO:0097105)5.54668573
9short-term memory (GO:0007614)5.43233319
10vocalization behavior (GO:0071625)5.39627489
11neuron cell-cell adhesion (GO:0007158)5.31393013
12postsynaptic membrane organization (GO:0001941)5.30292589
13synaptic vesicle exocytosis (GO:0016079)5.06443373
14collagen fibril organization (GO:0030199)5.00590973
15presynaptic membrane organization (GO:0097090)4.95947476
16synaptic vesicle maturation (GO:0016188)4.93233792
17regulation of glutamate receptor signaling pathway (GO:1900449)4.85056127
18regulation of synaptic vesicle exocytosis (GO:2000300)4.69261496
19glutamate secretion (GO:0014047)4.52329855
20chondrocyte proliferation (GO:0035988)4.46297151
21neurotransmitter secretion (GO:0007269)4.35250767
22kidney mesenchyme development (GO:0072074)4.28744795
23protein heterotrimerization (GO:0070208)4.28263366
24positive regulation of membrane potential (GO:0045838)4.28005869
25locomotory exploration behavior (GO:0035641)4.26279990
26endodermal cell differentiation (GO:0035987)4.22403886
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.21291308
28regulation of synaptic vesicle transport (GO:1902803)4.19309204
29positive regulation of synapse assembly (GO:0051965)4.15793341
30synaptic vesicle docking involved in exocytosis (GO:0016081)4.11993857
31synaptic transmission, glutamatergic (GO:0035249)4.09684762
32layer formation in cerebral cortex (GO:0021819)4.08591471
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.07934466
34ionotropic glutamate receptor signaling pathway (GO:0035235)4.07865388
35positive regulation of dendritic spine morphogenesis (GO:0061003)4.02882797
36neuron-neuron synaptic transmission (GO:0007270)4.02645377
37gamma-aminobutyric acid signaling pathway (GO:0007214)4.01888432
38positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.97355178
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.97334782
40metanephric mesenchyme development (GO:0072075)3.96577670
41response to gravity (GO:0009629)3.95493986
42neurotransmitter-gated ion channel clustering (GO:0072578)3.94936552
43positive regulation of dendritic spine development (GO:0060999)3.93070536
44regulation of postsynaptic membrane potential (GO:0060078)3.87074841
45negative regulation of chondrocyte differentiation (GO:0032331)3.85564916
46regulation of vesicle fusion (GO:0031338)3.84810716
47glutamate receptor signaling pathway (GO:0007215)3.79099275
48regulation of dendritic spine morphogenesis (GO:0061001)3.74557988
49lymphangiogenesis (GO:0001946)3.70176309
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.68587318
51cell migration involved in heart development (GO:0060973)3.66943721
52righting reflex (GO:0060013)3.65929419
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.65828000
54mesenchymal-epithelial cell signaling (GO:0060638)3.64563383
55neuron recognition (GO:0008038)3.63905809
56exploration behavior (GO:0035640)3.61484711
57regulation of protein kinase A signaling (GO:0010738)3.60769021
58positive regulation of vesicle fusion (GO:0031340)3.58537095
59dendritic spine morphogenesis (GO:0060997)3.56681562
60transmission of nerve impulse (GO:0019226)3.55596904
61endocardial cushion morphogenesis (GO:0003203)3.51430202
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50863429
63response to histamine (GO:0034776)3.50637009
64regulation of dendritic spine development (GO:0060998)3.49547033
65cell adhesion mediated by integrin (GO:0033627)3.49330702
66regulation of neuronal synaptic plasticity (GO:0048168)3.48289517
67positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46101931
68regulation of long-term neuronal synaptic plasticity (GO:0048169)3.44030412
69negative regulation of axon extension involved in axon guidance (GO:0048843)3.43325523
70cornea development in camera-type eye (GO:0061303)3.42118122
71positive regulation of synapse maturation (GO:0090129)3.40784762
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40549250
73neurotransmitter transport (GO:0006836)3.40231246
74cartilage condensation (GO:0001502)3.37837365
75cell aggregation (GO:0098743)3.37837365
76axonal fasciculation (GO:0007413)3.36468735
77mesenchyme morphogenesis (GO:0072132)3.36300200
78bone trabecula formation (GO:0060346)3.36017875
79collagen metabolic process (GO:0032963)3.35022055
80sequestering of extracellular ligand from receptor (GO:0035581)3.34051974
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.33971964
82negative regulation of axon guidance (GO:1902668)3.33630530
83G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.33460137
84regulation of neurotransmitter levels (GO:0001505)3.32177668
85regulation of synaptic transmission, GABAergic (GO:0032228)3.32053353
86long-term memory (GO:0007616)3.31577131
87skin morphogenesis (GO:0043589)3.30327025
88muscle cell cellular homeostasis (GO:0046716)3.29342806
89collagen catabolic process (GO:0030574)3.29285936
90neuromuscular synaptic transmission (GO:0007274)3.27904310
91membrane hyperpolarization (GO:0060081)3.26523548
92regulation of synapse assembly (GO:0051963)3.25293745
93left/right pattern formation (GO:0060972)3.22714715
94lung vasculature development (GO:0060426)3.21561580
95membrane depolarization (GO:0051899)3.20529948
96dermatan sulfate biosynthetic process (GO:0030208)3.20302980
97extracellular matrix assembly (GO:0085029)3.20019960
98paraxial mesoderm development (GO:0048339)3.18905905
99generation of neurons (GO:0048699)3.17224603
100startle response (GO:0001964)3.15774189
101positive regulation of neurotransmitter transport (GO:0051590)3.14858434
102negative regulation of nitric-oxide synthase activity (GO:0051001)3.12505507
103regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12060313
104social behavior (GO:0035176)3.11988291
105intraspecies interaction between organisms (GO:0051703)3.11988291
106extracellular fibril organization (GO:0043206)3.11208879
107regulation of respiratory system process (GO:0044065)3.10797735
108regulation of neurotransmitter secretion (GO:0046928)3.10475233
109artery development (GO:0060840)3.07584797
110negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.07488439
111cochlea morphogenesis (GO:0090103)3.06638605
112multicellular organismal macromolecule metabolic process (GO:0044259)3.05624030
113heparan sulfate proteoglycan metabolic process (GO:0030201)3.05588382
114behavioral fear response (GO:0001662)3.05519473
115behavioral defense response (GO:0002209)3.05519473
116GTP biosynthetic process (GO:0006183)3.05226598
117female mating behavior (GO:0060180)3.04551751
118membrane assembly (GO:0071709)3.03929069
119regulation of timing of cell differentiation (GO:0048505)3.01977971
120muscle cell migration (GO:0014812)2.99188495
121regulation of synaptic plasticity (GO:0048167)2.98531862
122cerebellar Purkinje cell layer development (GO:0021680)2.98185307
123neuromuscular process controlling posture (GO:0050884)2.97986731
124multicellular organismal catabolic process (GO:0044243)2.97515265
125negative regulation of cartilage development (GO:0061037)2.96780203
126negative regulation of muscle hypertrophy (GO:0014741)2.96761643
127gamma-aminobutyric acid transport (GO:0015812)2.96271714
128regulation of synapse organization (GO:0050807)2.95716633
129embryonic foregut morphogenesis (GO:0048617)2.95712946
130planar cell polarity pathway involved in neural tube closure (GO:0090179)2.95700875
131long-term synaptic potentiation (GO:0060291)2.95698920
132dorsal/ventral axis specification (GO:0009950)2.95159402
133respiratory electron transport chain (GO:0022904)2.94147257
134positive regulation of neurotransmitter secretion (GO:0001956)2.93978361
135regulation of glutamate secretion (GO:0014048)2.93199795
136myoblast fusion (GO:0007520)2.92385113
137regulation of synaptic transmission, glutamatergic (GO:0051966)2.90720799
138midgut development (GO:0007494)2.90258845
139synapse assembly (GO:0007416)2.90123464
140fear response (GO:0042596)2.89507566
141synaptic transmission (GO:0007268)2.88786629
142dermatan sulfate metabolic process (GO:0030205)2.88664799
143multicellular organismal metabolic process (GO:0044236)2.87647588
144negative regulation of protein localization to cell surface (GO:2000009)2.87419686
145behavioral response to cocaine (GO:0048148)2.86049016
146G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85787466
147regulation of heart morphogenesis (GO:2000826)2.85778500
148electron transport chain (GO:0022900)2.85519025
149substrate-dependent cell migration (GO:0006929)2.85285615
150regulation of neurotransmitter transport (GO:0051588)2.84299096
151positive regulation of neuroblast proliferation (GO:0002052)2.84095852
152regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.83645447
153positive regulation of cartilage development (GO:0061036)2.82793749
154regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.81174168
155regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81006559
156synaptic vesicle endocytosis (GO:0048488)2.80483759
157regulation of calcium ion-dependent exocytosis (GO:0017158)2.79969247
158dendrite morphogenesis (GO:0048813)2.79918064
159positive regulation of male gonad development (GO:2000020)2.78963502
160positive regulation of synaptic transmission (GO:0050806)2.78413966
161mesodermal cell differentiation (GO:0048333)2.77203058
162substrate adhesion-dependent cell spreading (GO:0034446)2.77186026
163negative regulation of embryonic development (GO:0045992)2.76915485
164epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.76597463
165regulation of neuroblast proliferation (GO:1902692)2.76182596
166neuron projection extension involved in neuron projection guidance (GO:1902284)2.73000962
167axon extension involved in axon guidance (GO:0048846)2.73000962
168heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.72616240
169regulation of chondrocyte differentiation (GO:0032330)2.72428569
170negative chemotaxis (GO:0050919)2.71266959
171outer ear morphogenesis (GO:0042473)2.69636743
172regulation of glomerular filtration (GO:0003093)2.69302709
173glomerulus development (GO:0032835)2.68900634
174neural crest cell development (GO:0014032)2.68283281
175regulation of transforming growth factor beta2 production (GO:0032909)2.66995652
176regulation of development, heterochronic (GO:0040034)2.66653155
177tongue development (GO:0043586)2.63613680
178endocardial cushion development (GO:0003197)2.63497263
179atrioventricular valve morphogenesis (GO:0003181)2.61753109
180regulation of axon guidance (GO:1902667)2.61327541
181extracellular matrix organization (GO:0030198)2.60774681
182pericardium development (GO:0060039)2.60692640
183regulation of organ formation (GO:0003156)2.60383460
184extracellular structure organization (GO:0043062)2.60034177
185extracellular matrix disassembly (GO:0022617)2.59878930
186vasculature development (GO:0001944)2.59534392
187regulation of cartilage development (GO:0061035)2.57922858
188regulation of axon extension involved in axon guidance (GO:0048841)2.57504139
189response to BMP (GO:0071772)2.55277385
190cellular response to BMP stimulus (GO:0071773)2.55277385
191hippo signaling (GO:0035329)2.55097182
192wound healing, spreading of epidermal cells (GO:0035313)2.55009520
193regulation of secondary heart field cardioblast proliferation (GO:0003266)2.54271324
194regulation of cardioblast proliferation (GO:0003264)2.54271324
195smooth muscle tissue development (GO:0048745)2.54154341
196glial cell migration (GO:0008347)2.53304456
197retina vasculature morphogenesis in camera-type eye (GO:0061299)2.53244245
198cellular response to vitamin (GO:0071295)2.52242319
199G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.52130484

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.17713700
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.81660622
3GBX2_23144817_ChIP-Seq_PC3_Human3.64520944
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.35463263
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21671966
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09686657
7WT1_19549856_ChIP-ChIP_CCG9911_Human3.05320719
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.90878091
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.85548393
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.85548393
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.79543105
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.76977652
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74241347
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.67702472
15* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.66473540
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.60148060
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60046166
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57168981
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.54840530
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46653139
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45608772
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42682922
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.40934309
24REST_21632747_ChIP-Seq_MESCs_Mouse2.30552452
25BRD4_25478319_ChIP-Seq_HGPS_Human2.27718405
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.24593451
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24144855
28AR_21572438_ChIP-Seq_LNCaP_Human2.23537056
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22643799
30* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.21247336
31TAF15_26573619_Chip-Seq_HEK293_Human2.21206057
32EP300_21415370_ChIP-Seq_HL-1_Mouse2.20500553
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.14619891
34* CJUN_26792858_Chip-Seq_BT549_Human2.14488579
35* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.14161122
36RARB_27405468_Chip-Seq_BRAIN_Mouse2.13406803
37CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09912710
38SALL1_21062744_ChIP-ChIP_HESCs_Human2.05962422
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.97364274
40DROSHA_22980978_ChIP-Seq_HELA_Human1.96500222
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95150674
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93075049
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.87999478
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.87375347
45TP53_16413492_ChIP-PET_HCT116_Human1.72496825
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71847496
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.66188397
48TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.63600608
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.63576632
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.61060517
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.61060517
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59569026
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56110836
54* SMAD4_21799915_ChIP-Seq_A2780_Human1.55235738
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.54702128
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53257403
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50077330
58P300_19829295_ChIP-Seq_ESCs_Human1.48129391
59* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47790395
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46717736
61ZNF274_21170338_ChIP-Seq_K562_Hela1.46575090
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.44903053
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43921931
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42946070
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42157846
66IGF1R_20145208_ChIP-Seq_DFB_Human1.41236009
67TBX3_20139965_ChIP-Seq_ESCs_Mouse1.39327122
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39138362
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38710751
70TBX3_20139965_ChIP-Seq_MESCs_Mouse1.38546395
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38507910
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.37578538
73FUS_26573619_Chip-Seq_HEK293_Human1.33798452
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33500229
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31352695
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.29809213
77MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.27177411
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27132213
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.26330479
80RNF2_27304074_Chip-Seq_NSC_Mouse1.26141690
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25745160
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23691845
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22580533
84VDR_22108803_ChIP-Seq_LS180_Human1.21855540
85* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21671462
86SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.20389867
87AHR_22903824_ChIP-Seq_MCF-7_Human1.20084617
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19697411
89AR_25329375_ChIP-Seq_VCAP_Human1.19438881
90* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18711622
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.18459669
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.16814845
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.15713871
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14456879
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13945206
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13455118
97POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11714012
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.10581739
99* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09285808
100JUN_21703547_ChIP-Seq_K562_Human1.08338132
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07181582
102RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05424343
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05040589
104SA1_22415368_ChIP-Seq_MEFs_Mouse1.04494413
105* ER_23166858_ChIP-Seq_MCF-7_Human1.04463525
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03778941
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03162092
108AR_19668381_ChIP-Seq_PC3_Human1.02546778
109STAT3_23295773_ChIP-Seq_U87_Human1.02317645
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.01725587
111* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01549463
112SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00298753
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00043502
114EWS_26573619_Chip-Seq_HEK293_Human0.99530240
115* TCF4_23295773_ChIP-Seq_U87_Human0.97374946
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97104637
117TP63_17297297_ChIP-ChIP_HaCaT_Human0.95238542
118* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93530427
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.92752185
120* RUNX2_22187159_ChIP-Seq_PCA_Human0.91656071
121* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90919292
122* BCAT_22108803_ChIP-Seq_LS180_Human0.89086155
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.88289126
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88194445
125PRDM14_20953172_ChIP-Seq_ESCs_Human0.87759343
126TP53_20018659_ChIP-ChIP_R1E_Mouse0.87196406
127* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85639603
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84584309
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.84169207
130* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.83131474
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82973343
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82401521
133FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82055608
134YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80721284
135WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80428733
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80331084
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79253787
138P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79102686
139TP53_18474530_ChIP-ChIP_U2OS_Human0.77431085
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.77128310
141KDM2B_26808549_Chip-Seq_REH_Human0.76500610
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75879639
143PCGF2_27294783_Chip-Seq_ESCs_Mouse0.75599911
144P53_22387025_ChIP-Seq_ESCs_Mouse0.74175205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.50254116
2MP0003880_abnormal_central_pattern5.51907268
3MP0004859_abnormal_synaptic_plasticity5.42861828
4MP0005257_abnormal_intraocular_pressure3.88522545
5MP0003635_abnormal_synaptic_transmissio3.80676325
6MP0005503_abnormal_tendon_morphology3.54909589
7MP0005275_abnormal_skin_tensile3.45619753
8MP0009745_abnormal_behavioral_response3.35139679
9MP0010030_abnormal_orbit_morphology3.32395096
10MP0002064_seizures3.24748057
11MP0003705_abnormal_hypodermis_morpholog3.14372901
12MP0009046_muscle_twitch3.09615042
13MP0003950_abnormal_plasma_membrane3.02483753
14MP0003279_aneurysm2.99883438
15MP0004270_analgesia2.95458486
16MP0001968_abnormal_touch/_nociception2.92296183
17MP0002063_abnormal_learning/memory/cond2.86804511
18MP0002272_abnormal_nervous_system2.70947939
19MP0002572_abnormal_emotion/affect_behav2.59830760
20MP0001542_abnormal_bone_strength2.57482539
21MP0002234_abnormal_pharynx_morphology2.50853703
22MP0002736_abnormal_nociception_after2.48135351
23MP0006276_abnormal_autonomic_nervous2.47485954
24MP0000751_myopathy2.46337236
25MP0001486_abnormal_startle_reflex2.42696454
26MP0006292_abnormal_olfactory_placode2.41942403
27MP0002734_abnormal_mechanical_nocicepti2.40101831
28MP0001958_emphysema2.33612144
29MP0008789_abnormal_olfactory_epithelium2.27115636
30MP0001440_abnormal_grooming_behavior2.24932643
31MP0002108_abnormal_muscle_morphology2.19896024
32MP0004142_abnormal_muscle_tone2.19825610
33MP0002067_abnormal_sensory_capabilities2.12738996
34MP0009250_abnormal_appendicular_skeleto2.08642192
35MP0009384_cardiac_valve_regurgitation2.03502969
36MP0010368_abnormal_lymphatic_system2.02466872
37MP0004145_abnormal_muscle_electrophysio2.02287123
38MP0005423_abnormal_somatic_nervous2.00401581
39MP0000750_abnormal_muscle_regeneration1.99762986
40MP0002735_abnormal_chemical_nociception1.97728875
41MP0000733_abnormal_muscle_development1.97397282
42MP0003122_maternal_imprinting1.94184414
43MP0002822_catalepsy1.92661576
44MP0001501_abnormal_sleep_pattern1.89925886
45MP0001970_abnormal_pain_threshold1.84466909
46MP0002557_abnormal_social/conspecific_i1.82622749
47MP0000767_abnormal_smooth_muscle1.82389913
48MP0006054_spinal_hemorrhage1.82221678
49MP0002837_dystrophic_cardiac_calcinosis1.78686176
50MP0002938_white_spotting1.78269345
51MP0002733_abnormal_thermal_nociception1.74605101
52MP0002184_abnormal_innervation1.74596077
53MP0000778_abnormal_nervous_system1.72579616
54MP0001905_abnormal_dopamine_level1.70917810
55MP0001529_abnormal_vocalization1.69984480
56MP0005508_abnormal_skeleton_morphology1.66012005
57MP0000955_abnormal_spinal_cord1.64225441
58MP0000749_muscle_degeneration1.60755126
59MP0000534_abnormal_ureter_morphology1.60337198
60MP0001188_hyperpigmentation1.59536942
61MP0010386_abnormal_urinary_bladder1.57730614
62MP0005386_behavior/neurological_phenoty1.56077208
63MP0004924_abnormal_behavior1.56077208
64MP0000428_abnormal_craniofacial_morphol1.52561134
65MP0003303_peritoneal_inflammation1.52177169
66MP0000049_abnormal_middle_ear1.52125553
67MP0005551_abnormal_eye_electrophysiolog1.50886314
68MP0000762_abnormal_tongue_morphology1.50216649
69MP0008569_lethality_at_weaning1.50020093
70MP0003942_abnormal_urinary_system1.48900936
71MP0002896_abnormal_bone_mineralization1.47900045
72MP0003385_abnormal_body_wall1.45148273
73MP0003755_abnormal_palate_morphology1.44669887
74MP0002882_abnormal_neuron_morphology1.43240126
75MP0003566_abnormal_cell_adhesion1.41341042
76MP0002282_abnormal_trachea_morphology1.37404142
77MP0002066_abnormal_motor_capabilities/c1.36795517
78MP0009053_abnormal_anal_canal1.35514168
79MP0003091_abnormal_cell_migration1.31838332
80MP0002909_abnormal_adrenal_gland1.28147071
81MP0002233_abnormal_nose_morphology1.27333398
82MP0005197_abnormal_uvea_morphology1.23472200
83MP0002932_abnormal_joint_morphology1.21535479
84MP0004811_abnormal_neuron_physiology1.20820388
85MP0003941_abnormal_skin_development1.20685675
86MP0003935_abnormal_craniofacial_develop1.17421939
87MP0003879_abnormal_hair_cell1.17081951
88MP0009780_abnormal_chondrocyte_physiolo1.16662911
89MP0006072_abnormal_retinal_apoptosis1.13941422
90MP0003787_abnormal_imprinting1.12279188
91MP0005623_abnormal_meninges_morphology1.10192211
92MP0003329_amyloid_beta_deposits1.08912596
93MP0000569_abnormal_digit_pigmentation1.08907618
94MP0003646_muscle_fatigue1.07351918
95MP0002229_neurodegeneration1.05299161
96MP0005023_abnormal_wound_healing1.05119117
97MP0000759_abnormal_skeletal_muscle1.04343549
98MP0002295_abnormal_pulmonary_circulatio1.03976903
99MP0002089_abnormal_postnatal_growth/wei1.03667059
100MP0004742_abnormal_vestibular_system1.03334304
101MP0003937_abnormal_limbs/digits/tail_de1.02759232
102MP0000163_abnormal_cartilage_morphology1.02172404
103MP0002638_abnormal_pupillary_reflex1.01980052
104MP0002152_abnormal_brain_morphology1.01946790
105MP0004084_abnormal_cardiac_muscle1.01880135
106MP0003315_abnormal_perineum_morphology1.01190154
107MP0002177_abnormal_outer_ear1.00936128
108MP0003283_abnormal_digestive_organ0.99935227
109MP0003633_abnormal_nervous_system0.99525431
110MP0008874_decreased_physiological_sensi0.99116824
111MP0000432_abnormal_head_morphology0.98811210
112MP0001502_abnormal_circadian_rhythm0.97617356
113MP0002752_abnormal_somatic_nervous0.97327718
114MP0001963_abnormal_hearing_physiology0.96527357
115MP0002116_abnormal_craniofacial_bone0.95381898
116MP0001984_abnormal_olfaction0.95051608
117MP0001286_abnormal_eye_development0.94196997
118MP0002114_abnormal_axial_skeleton0.93634614
119MP0004036_abnormal_muscle_relaxation0.92982069
120MP0004885_abnormal_endolymph0.92573011
121MP0000613_abnormal_salivary_gland0.92514231
122MP0002249_abnormal_larynx_morphology0.92253225
123MP0005646_abnormal_pituitary_gland0.90863737
124MP0004134_abnormal_chest_morphology0.90795012
125MP0005171_absent_coat_pigmentation0.89454985
126MP0004858_abnormal_nervous_system0.88898015
127MP0001664_abnormal_digestion0.88765128
128MP0002109_abnormal_limb_morphology0.87323562
129MP0005253_abnormal_eye_physiology0.85015121
130MP0002332_abnormal_exercise_endurance0.84704592
131MP0002697_abnormal_eye_size0.84529617
132MP0005645_abnormal_hypothalamus_physiol0.84381827
133MP0001293_anophthalmia0.84191127
134MP0002090_abnormal_vision0.81929810
135MP0002113_abnormal_skeleton_development0.81904842
136MP0002115_abnormal_skeleton_extremities0.81671595
137MP0002092_abnormal_eye_morphology0.81491867
138MP0002876_abnormal_thyroid_physiology0.81257478
139MP0003631_nervous_system_phenotype0.79870438
140MP0005369_muscle_phenotype0.79374274
141MP0005409_darkened_coat_color0.79182045
142MP0004085_abnormal_heartbeat0.78895082
143MP0004215_abnormal_myocardial_fiber0.78743460
144MP0008872_abnormal_physiological_respon0.78285479
145MP0002060_abnormal_skin_morphology0.78090379
146MP0000013_abnormal_adipose_tissue0.77912061
147MP0000537_abnormal_urethra_morphology0.77806755
148MP0001243_abnormal_dermal_layer0.76859592
149MP0002102_abnormal_ear_morphology0.76716575
150MP0009379_abnormal_foot_pigmentation0.72973069
151MP0004043_abnormal_pH_regulation0.72739389
152MP0005620_abnormal_muscle_contractility0.71615031
153MP0004087_abnormal_muscle_fiber0.70916317
154MP0004883_abnormal_blood_vessel0.70827164
155MP0003634_abnormal_glial_cell0.70610870
156MP0002160_abnormal_reproductive_system0.69894179
157MP0002069_abnormal_eating/drinking_beha0.69598261
158MP0004484_altered_response_of0.69066141
159MP0001177_atelectasis0.68947118
160MP0002751_abnormal_autonomic_nervous0.68296293
161MP0000026_abnormal_inner_ear0.67577146
162MP0005535_abnormal_body_temperature0.66701865
163MP0002128_abnormal_blood_circulation0.66452439
164MP0001943_abnormal_respiration0.65247013
165MP0001879_abnormal_lymphatic_vessel0.65190511
166MP0000631_abnormal_neuroendocrine_gland0.65085710
167MP0001986_abnormal_taste_sensitivity0.64720802
168MP0001348_abnormal_lacrimal_gland0.64165346
169MP0000538_abnormal_urinary_bladder0.63842057
170MP0003119_abnormal_digestive_system0.63455800
171MP0003137_abnormal_impulse_conducting0.63268177
172MP0005390_skeleton_phenotype0.62778542
173MP0000462_abnormal_digestive_system0.62527434
174MP0005595_abnormal_vascular_smooth0.61539945
175MP0005164_abnormal_response_to0.61238060
176MP0002106_abnormal_muscle_physiology0.60359588
177MP0001299_abnormal_eye_distance/0.59673762
178MP0006138_congestive_heart_failure0.59281279
179MP0001614_abnormal_blood_vessel0.58913005
180MP0003115_abnormal_respiratory_system0.58869303
181MP0000920_abnormal_myelination0.58582192
182MP0005499_abnormal_olfactory_system0.57773967
183MP0005394_taste/olfaction_phenotype0.57773967
184MP0003121_genomic_imprinting0.57320038
185MP0004272_abnormal_basement_membrane0.55333926

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.92368571
2Premature rupture of membranes (HP:0001788)6.75634069
3Atonic seizures (HP:0010819)5.74331696
4Protrusio acetabuli (HP:0003179)5.48365462
5Aortic dissection (HP:0002647)5.39844090
6Popliteal pterygium (HP:0009756)5.38303544
7Focal seizures (HP:0007359)5.02659799
8Epileptic encephalopathy (HP:0200134)4.95443577
9Myokymia (HP:0002411)4.61634381
10Febrile seizures (HP:0002373)4.58764543
11Absence seizures (HP:0002121)4.29766462
12Visual hallucinations (HP:0002367)4.27765883
13Amblyopia (HP:0000646)4.25276851
14Soft skin (HP:0000977)4.12851132
15Aortic aneurysm (HP:0004942)4.05439556
16Dialeptic seizures (HP:0011146)3.94943952
17Hyperthyroidism (HP:0000836)3.90222409
18Ankle contracture (HP:0006466)3.83851141
19Type 2 muscle fiber atrophy (HP:0003554)3.83845329
20Arterial tortuosity (HP:0005116)3.83300596
21Vascular tortuosity (HP:0004948)3.79208578
22Progressive cerebellar ataxia (HP:0002073)3.73198688
23Amniotic constriction ring (HP:0009775)3.66352467
24Abnormality of placental membranes (HP:0011409)3.66352467
25Generalized tonic-clonic seizures (HP:0002069)3.65925721
26Thin ribs (HP:0000883)3.61413812
27Pterygium (HP:0001059)3.60673005
28Bladder diverticulum (HP:0000015)3.57222172
29Follicular hyperkeratosis (HP:0007502)3.56687428
30Neonatal short-limb short stature (HP:0008921)3.52994393
31Type 1 muscle fiber predominance (HP:0003803)3.52314811
32Aplasia of the musculature (HP:0100854)3.43481921
33Muscle hypertrophy of the lower extremities (HP:0008968)3.37906391
34Muscle fiber atrophy (HP:0100295)3.33603489
35Abnormality of dentin (HP:0010299)3.31708034
36Atrophic scars (HP:0001075)3.24494058
37Hyperventilation (HP:0002883)3.22778379
38Broad-based gait (HP:0002136)3.20687872
39Acute necrotizing encephalopathy (HP:0006965)3.13496701
40Abnormality of the neuromuscular junction (HP:0003398)3.06389197
41Fatigable weakness (HP:0003473)3.06389197
42Spondylolisthesis (HP:0003302)3.03665723
43Peritonitis (HP:0002586)3.02908642
44Mitochondrial inheritance (HP:0001427)2.90142694
45Progressive macrocephaly (HP:0004481)2.88873344
46Shallow orbits (HP:0000586)2.88340801
47Genu recurvatum (HP:0002816)2.87810188
48Bowel incontinence (HP:0002607)2.87453683
49Broad metatarsal (HP:0001783)2.80974220
50Abnormal mitochondria in muscle tissue (HP:0008316)2.80758430
51Poor suck (HP:0002033)2.79569283
52Depression (HP:0000716)2.78387198
53Fragile skin (HP:0001030)2.77225404
54Hepatocellular necrosis (HP:0001404)2.76965815
55Agitation (HP:0000713)2.74855541
56Sleep apnea (HP:0010535)2.74657174
57Gowers sign (HP:0003391)2.73934872
58Mitral valve prolapse (HP:0001634)2.70651582
59Abnormal eating behavior (HP:0100738)2.69816088
60Anxiety (HP:0000739)2.69652538
61Obstructive sleep apnea (HP:0002870)2.67633571
62Abnormal large intestine physiology (HP:0012700)2.65304404
63Nuclear cataract (HP:0100018)2.62748089
64Optic disc pallor (HP:0000543)2.62567670
65Myotonia (HP:0002486)2.58454349
66Wide anterior fontanel (HP:0000260)2.54549436
67Wormian bones (HP:0002645)2.53373265
68Hypoventilation (HP:0002791)2.51855331
69Gaze-evoked nystagmus (HP:0000640)2.49783567
70Dysdiadochokinesis (HP:0002075)2.48519177
71Polyphagia (HP:0002591)2.47898552
72Limited hip movement (HP:0008800)2.46955580
73Zonular cataract (HP:0010920)2.46738341
74Dysmetria (HP:0001310)2.46172651
75Hip contracture (HP:0003273)2.45500900
76Round ear (HP:0100830)2.44414023
77Generalized hypotonia (HP:0001290)2.43200890
78Spinal rigidity (HP:0003306)2.41281660
79Acute encephalopathy (HP:0006846)2.40472976
80Truncus arteriosus (HP:0001660)2.39987347
81Megalencephaly (HP:0001355)2.36528056
82Blue sclerae (HP:0000592)2.35327437
83Supranuclear gaze palsy (HP:0000605)2.35320479
84Coronal craniosynostosis (HP:0004440)2.32702864
85Increased corneal curvature (HP:0100692)2.32348821
86Keratoconus (HP:0000563)2.32348821
87Esotropia (HP:0000565)2.31310718
88Bowel diverticulosis (HP:0005222)2.30741328
89Increased CSF lactate (HP:0002490)2.28423919
90Pheochromocytoma (HP:0002666)2.27406289
91Psychosis (HP:0000709)2.27215359
92Scanning speech (HP:0002168)2.27152449
93Slender build (HP:0001533)2.26414638
94Dilatation of the ascending aorta (HP:0005111)2.25686882
95Absent speech (HP:0001344)2.25394523
96Mildly elevated creatine phosphokinase (HP:0008180)2.25192212
97Neuroendocrine neoplasm (HP:0100634)2.24660777
98Abnormality of the labia minora (HP:0012880)2.24281860
99Abnormality of the umbilical cord (HP:0010881)2.22505936
100Narrow nasal bridge (HP:0000446)2.21986641
101Atelectasis (HP:0100750)2.21753145
102Sudden death (HP:0001699)2.20566749
103Abnormal hair whorl (HP:0010721)2.20146093
104Hyperextensible skin (HP:0000974)2.19796225
105Status epilepticus (HP:0002133)2.18388261
106Weak cry (HP:0001612)2.18373383
107Tibial bowing (HP:0002982)2.17854786
108Wrist flexion contracture (HP:0001239)2.15959540
109Failure to thrive in infancy (HP:0001531)2.15148913
110Neoplasm of the peripheral nervous system (HP:0100007)2.13853784
111Malignant hyperthermia (HP:0002047)2.13786949
112Overgrowth (HP:0001548)2.13533772
113Fetal akinesia sequence (HP:0001989)2.12944234
114Knee flexion contracture (HP:0006380)2.11891334
115Hypoplastic heart (HP:0001961)2.10232375
116Abnormalities of placenta or umbilical cord (HP:0001194)2.09127655
117Truncal ataxia (HP:0002078)2.08804927
118Biconcave vertebral bodies (HP:0004586)2.07437325
119Decreased muscle mass (HP:0003199)2.06190487
120Aortic regurgitation (HP:0001659)2.04352598
121Bronchomalacia (HP:0002780)2.04340478
122Progressive inability to walk (HP:0002505)2.03063436
123Broad ribs (HP:0000885)2.02391047
124Concave nail (HP:0001598)2.01591936
125Easy fatigability (HP:0003388)2.01347293
126Joint laxity (HP:0001388)2.01169519
127Mild short stature (HP:0003502)2.00162695
128Absent frontal sinuses (HP:0002688)1.99674508
129Cystic hygroma (HP:0000476)1.99398122
130Action tremor (HP:0002345)1.98636088
131Epileptiform EEG discharges (HP:0011182)1.97153750
132Generalized amyotrophy (HP:0003700)1.96630466
133Camptodactyly of toe (HP:0001836)1.96610303
134Poor eye contact (HP:0000817)1.94960304
135Generalized myoclonic seizures (HP:0002123)1.94783394
136Insidious onset (HP:0003587)1.94549965
137Termporal pattern (HP:0011008)1.94549965
138Excessive salivation (HP:0003781)1.92893887
139Drooling (HP:0002307)1.92893887
140Femoral bowing (HP:0002980)1.91803727
141Hypophosphatemic rickets (HP:0004912)1.88749229
142Congenital glaucoma (HP:0001087)1.87869214
143Ectopia lentis (HP:0001083)1.87050679
144Limb-girdle muscle weakness (HP:0003325)1.86680755
145Limb dystonia (HP:0002451)1.86366623
146Abnormality of the tricuspid valve (HP:0001702)1.85906347
147Absent/shortened dynein arms (HP:0200106)1.85096274
148Dynein arm defect of respiratory motile cilia (HP:0012255)1.85096274
149Hemiparesis (HP:0001269)1.84875969
150Progressive external ophthalmoplegia (HP:0000590)1.84791736
151Diplopia (HP:0000651)1.84768693
152Abnormality of binocular vision (HP:0011514)1.84768693
153Impaired vibration sensation in the lower limbs (HP:0002166)1.84521514
154Abnormal delivery (HP:0001787)1.83858977
155Increased variability in muscle fiber diameter (HP:0003557)1.83674195
156Restlessness (HP:0000711)1.83437672
157Impaired social interactions (HP:0000735)1.83406818
158Abnormal social behavior (HP:0012433)1.83406818
159Oligomenorrhea (HP:0000876)1.83359978
160Delusions (HP:0000746)1.82572375
161Hypercortisolism (HP:0001578)1.80719016
162EEG with generalized epileptiform discharges (HP:0011198)1.80631360
163Elbow flexion contracture (HP:0002987)1.80054213
164Abnormality of the calf musculature (HP:0001430)1.78638624
165Menorrhagia (HP:0000132)1.78185248
166Deformed tarsal bones (HP:0008119)1.78039059
167Respiratory failure (HP:0002878)1.77365990
168Genetic anticipation (HP:0003743)1.77237511
169Gait imbalance (HP:0002141)1.76938065
170Anterior segment dysgenesis (HP:0007700)1.76345143
171Stillbirth (HP:0003826)1.76296071
172Calcaneovalgus deformity (HP:0001848)1.75875035
173Short 4th metacarpal (HP:0010044)1.75114686
174Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75114686
175Cervical subluxation (HP:0003308)1.74930518
176Distal arthrogryposis (HP:0005684)1.74250140
177Abnormality of the acetabulum (HP:0003170)1.73629871
178Mitral regurgitation (HP:0001653)1.72154436
179Sporadic (HP:0003745)1.72021968
180Emotional lability (HP:0000712)1.71875670
181Mesomelia (HP:0003027)1.71525400
182Aplasia/Hypoplasia involving the musculature (HP:0001460)1.71346778
183Mutism (HP:0002300)1.71169400
184Congenital primary aphakia (HP:0007707)1.70869354
185Sensory axonal neuropathy (HP:0003390)1.70696870
186Hallux valgus (HP:0001822)1.70579221
187Infantile muscular hypotonia (HP:0008947)1.70422410
188Achilles tendon contracture (HP:0001771)1.69915813
189Cerebral aneurysm (HP:0004944)1.68910118
190Abnormality of the anterior chamber (HP:0000593)1.68726719
191Slender long bone (HP:0003100)1.68420765
192Breech presentation (HP:0001623)1.66540360
193Deviation of the hallux (HP:0010051)1.66417049
194Delayed gross motor development (HP:0002194)1.66227804
195Broad long bones (HP:0005622)1.66202529
196Aortic valve stenosis (HP:0001650)1.64763655

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.69713597
2TLK14.07659994
3MAP3K124.01299131
4MOS3.72863931
5NTRK33.40187927
6EPHB23.37644357
7MAP3K43.10754467
8EPHA43.03072900
9MAP2K72.82178367
10PRPF4B2.81589045
11NEK92.80471850
12MINK12.61288596
13FES2.55532457
14PDGFRA2.47231331
15MAP2K42.17357659
16CDK192.11625512
17MARK12.09534502
18MAP3K92.05382428
19PIK3CG2.03063642
20PAK21.96722152
21DDR21.95625430
22LATS11.93947558
23MKNK21.84578221
24FER1.84217567
25PTK21.83307063
26FLT31.83272622
27DAPK21.76636155
28TGFBR21.76274038
29PNCK1.70682198
30PLK21.63870628
31MET1.54932175
32TNIK1.54303018
33TTN1.50355073
34PAK61.44494761
35NME11.41949579
36PRKCG1.33620057
37DAPK31.33239400
38CDK81.32245820
39WEE11.27326299
40CDK51.25104573
41RIPK41.24028840
42PAK41.22480918
43STK31.22064641
44CAMK2A1.19240634
45NTRK21.17976314
46DAPK11.17297443
47GRK51.15081182
48AKT31.14889219
49MAPK131.14154567
50CAMK2B1.13534341
51MAPK151.08375689
52ERBB41.07895960
53NTRK11.07671420
54MELK1.06661257
55NUAK11.03325959
56TIE11.01479932
57KSR20.96153128
58GRK70.95881697
59GRK10.95585640
60MAP4K20.94908990
61CAMKK10.92551518
62PINK10.92163604
63UHMK10.91755240
64STK38L0.91711947
65STK380.90960757
66KSR10.90394268
67MYLK0.89190213
68DMPK0.88763727
69BRSK20.88374829
70OXSR10.88256365
71GSK3A0.88148129
72BRAF0.86373070
73MAP3K110.85149693
74MAPK70.85146297
75CAMK2D0.84047411
76CAMKK20.83507770
77BMPR20.83016491
78SIK20.81920912
79NEK10.81531381
80ARAF0.80598116
81CAMK2G0.79971751
82ADRBK20.78482654
83IRAK10.78151357
84LIMK10.77914576
85STK110.77181394
86CDK140.77176007
87ROCK20.73996298
88MARK20.72434847
89PHKG20.72066637
90PHKG10.72066637
91MAP2K10.71773125
92PRKCE0.71151207
93WNK10.71083790
94CDK90.70567589
95PDGFRB0.70094075
96LATS20.69714940
97PAK30.69327840
98DYRK1B0.68901737
99TAOK10.67484282
100TGFBR10.66574374
101ADRBK10.65372656
102ILK0.65145116
103SIK10.63545700
104PKN20.62744878
105CDK180.60564027
106CAMK10.59566050
107PTK2B0.59412754
108CDK150.59408571
109MAP3K100.59042889
110RAF10.56755838
111TESK20.54613984
112STK390.54602983
113PRKD30.54213294
114CDK11A0.53400458
115IRAK20.53135422
116WNK40.53070408
117PRKCZ0.53066987
118PLK30.52329309
119SGK4940.52203265
120SGK2230.52203265
121SGK10.52046127
122PKN10.52024016
123BRSK10.51656079
124CSNK1G20.51593159
125DYRK1A0.50719564
126ROCK10.50640262
127CDK70.50530274
128FGFR10.47502237
129STK160.47173455
130CAMK40.46618424
131MKNK10.46062538
132ERBB30.44437427
133EIF2AK30.44432505
134PDPK10.42606457
135AURKA0.41943140
136CSNK1G10.41837184
137PIK3CA0.39445929
138BCKDK0.38460022
139MAPKAPK50.37504381
140CSNK1E0.37495789
141MAP3K10.37321757
142PRKACA0.36832997
143PRKD20.36564969
144SGK20.36500494
145TNK20.35077158
146CSNK1G30.35027590
147PIM20.34629381
148ABL20.34110530
149WNK30.33795238
150VRK20.33675570
151MAPK100.33261769
152NEK20.33039073
153MUSK0.32872438
154BMPR1B0.32496943
155RPS6KA20.32141035
156RPS6KA30.32041644
157PAK10.31904647
158DYRK30.31693086
159CDK30.30259405
160CLK10.28982020
161DYRK20.28344579

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.21291891
2Nicotine addiction_Homo sapiens_hsa050334.06999283
3Synaptic vesicle cycle_Homo sapiens_hsa047213.50458391
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.00952393
5Oxidative phosphorylation_Homo sapiens_hsa001902.99247342
6Focal adhesion_Homo sapiens_hsa045102.95043143
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.77185177
8Basal cell carcinoma_Homo sapiens_hsa052172.71648213
9Protein digestion and absorption_Homo sapiens_hsa049742.63341623
10GABAergic synapse_Homo sapiens_hsa047272.61119666
11Long-term potentiation_Homo sapiens_hsa047202.49419622
12Morphine addiction_Homo sapiens_hsa050322.47057577
13Olfactory transduction_Homo sapiens_hsa047402.46123970
14Hedgehog signaling pathway_Homo sapiens_hsa043402.39777517
15Parkinsons disease_Homo sapiens_hsa050122.36698885
16Circadian entrainment_Homo sapiens_hsa047132.36373397
17Hippo signaling pathway_Homo sapiens_hsa043902.36028646
18Glutamatergic synapse_Homo sapiens_hsa047242.34554986
19Collecting duct acid secretion_Homo sapiens_hsa049662.24361648
20TGF-beta signaling pathway_Homo sapiens_hsa043502.24168023
21Cardiac muscle contraction_Homo sapiens_hsa042602.14970961
22Alzheimers disease_Homo sapiens_hsa050102.13923277
23Phototransduction_Homo sapiens_hsa047442.12111967
24Amphetamine addiction_Homo sapiens_hsa050312.09435581
25Cholinergic synapse_Homo sapiens_hsa047252.00690319
26Dopaminergic synapse_Homo sapiens_hsa047281.97861257
27Proteoglycans in cancer_Homo sapiens_hsa052051.97720356
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.87769670
29Taste transduction_Homo sapiens_hsa047421.87691923
30Long-term depression_Homo sapiens_hsa047301.86107483
31Insulin secretion_Homo sapiens_hsa049111.82604084
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81682078
33Serotonergic synapse_Homo sapiens_hsa047261.75425843
34Salivary secretion_Homo sapiens_hsa049701.71551838
35Huntingtons disease_Homo sapiens_hsa050161.68804343
36Renin secretion_Homo sapiens_hsa049241.62456746
37PI3K-Akt signaling pathway_Homo sapiens_hsa041511.61845425
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.61065177
39Small cell lung cancer_Homo sapiens_hsa052221.55818419
40Calcium signaling pathway_Homo sapiens_hsa040201.52441909
41Amoebiasis_Homo sapiens_hsa051461.50966877
42Gastric acid secretion_Homo sapiens_hsa049711.50573101
43Oxytocin signaling pathway_Homo sapiens_hsa049211.47804547
44Cocaine addiction_Homo sapiens_hsa050301.47585501
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46453043
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46044843
47Adherens junction_Homo sapiens_hsa045201.44711841
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44121227
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43255013
50Vibrio cholerae infection_Homo sapiens_hsa051101.42845080
51MicroRNAs in cancer_Homo sapiens_hsa052061.40315519
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.39443045
53p53 signaling pathway_Homo sapiens_hsa041151.36851083
54GnRH signaling pathway_Homo sapiens_hsa049121.33377845
55Protein export_Homo sapiens_hsa030601.31092799
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28972112
57Gap junction_Homo sapiens_hsa045401.24370601
58Pathways in cancer_Homo sapiens_hsa052001.24251844
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22671282
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22238567
61Basal transcription factors_Homo sapiens_hsa030221.20878519
62Axon guidance_Homo sapiens_hsa043601.09750056
63Tight junction_Homo sapiens_hsa045301.09104813
64Melanogenesis_Homo sapiens_hsa049161.04752471
65Bladder cancer_Homo sapiens_hsa052191.00227472
66Estrogen signaling pathway_Homo sapiens_hsa049150.99663624
67cAMP signaling pathway_Homo sapiens_hsa040240.99325122
68Steroid biosynthesis_Homo sapiens_hsa001000.97395631
69Dilated cardiomyopathy_Homo sapiens_hsa054140.95278472
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94355157
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94174768
72ErbB signaling pathway_Homo sapiens_hsa040120.89824691
73Glioma_Homo sapiens_hsa052140.86961045
74Prostate cancer_Homo sapiens_hsa052150.86374191
75Cell cycle_Homo sapiens_hsa041100.85807505
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.85790045
77Colorectal cancer_Homo sapiens_hsa052100.83999201
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82497915
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81593598
80Thyroid cancer_Homo sapiens_hsa052160.79563837
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78616182
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77450954
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75331833
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73212318
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.73205211
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72036535
87Folate biosynthesis_Homo sapiens_hsa007900.71831999
88Oocyte meiosis_Homo sapiens_hsa041140.71663032
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70653768
90Type II diabetes mellitus_Homo sapiens_hsa049300.69412520
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61557946
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61288441
93Endometrial cancer_Homo sapiens_hsa052130.60483387
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59630322
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.59035620
96Chronic myeloid leukemia_Homo sapiens_hsa052200.58705550
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57299848
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56859024
99FoxO signaling pathway_Homo sapiens_hsa040680.54757498
100MAPK signaling pathway_Homo sapiens_hsa040100.54676038
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54476430
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54165792
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54093756
104Nucleotide excision repair_Homo sapiens_hsa034200.53973396
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53758681
106Choline metabolism in cancer_Homo sapiens_hsa052310.52945587
107Complement and coagulation cascades_Homo sapiens_hsa046100.52888338
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52458696
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51317592
110Notch signaling pathway_Homo sapiens_hsa043300.51062000
111Prion diseases_Homo sapiens_hsa050200.50666323
112Rheumatoid arthritis_Homo sapiens_hsa053230.50472492
113Lysine degradation_Homo sapiens_hsa003100.49850180
114Ras signaling pathway_Homo sapiens_hsa040140.49734317
115Glucagon signaling pathway_Homo sapiens_hsa049220.49026621
116Thyroid hormone synthesis_Homo sapiens_hsa049180.46811533
117Fanconi anemia pathway_Homo sapiens_hsa034600.46223546
118Pancreatic secretion_Homo sapiens_hsa049720.45033559
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.43919919
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43705740
121Renal cell carcinoma_Homo sapiens_hsa052110.43179143
122N-Glycan biosynthesis_Homo sapiens_hsa005100.43081700
123Malaria_Homo sapiens_hsa051440.41906694
124Alcoholism_Homo sapiens_hsa050340.38743618
125Wnt signaling pathway_Homo sapiens_hsa043100.38211441
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.37147403
127Sulfur metabolism_Homo sapiens_hsa009200.35540387
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35252976
129Dorso-ventral axis formation_Homo sapiens_hsa043200.35165939
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32979210
131VEGF signaling pathway_Homo sapiens_hsa043700.32946938
132Pancreatic cancer_Homo sapiens_hsa052120.31787069
133Phagosome_Homo sapiens_hsa041450.31718012
134Melanoma_Homo sapiens_hsa052180.31243702
135Nitrogen metabolism_Homo sapiens_hsa009100.31240953
136Rap1 signaling pathway_Homo sapiens_hsa040150.29483093
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28774242
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.28638226
139Insulin signaling pathway_Homo sapiens_hsa049100.28563220
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28214757
141Selenocompound metabolism_Homo sapiens_hsa004500.27512153
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26762294
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26673394
144Ovarian steroidogenesis_Homo sapiens_hsa049130.26421287
145Endocytosis_Homo sapiens_hsa041440.25916722
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25631816
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25333616
148Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24860680
149Circadian rhythm_Homo sapiens_hsa047100.24841835
150Sulfur relay system_Homo sapiens_hsa041220.24228356
151Arginine biosynthesis_Homo sapiens_hsa002200.23715416
152HTLV-I infection_Homo sapiens_hsa051660.23226840
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21022848
154Regulation of actin cytoskeleton_Homo sapiens_hsa048100.19698995
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18355384
156African trypanosomiasis_Homo sapiens_hsa051430.17952455
157Type I diabetes mellitus_Homo sapiens_hsa049400.15949122

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