LRRC18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.97108236
2motile cilium assembly (GO:0044458)9.93115301
3cell-cell recognition (GO:0009988)9.92356943
4plasma membrane fusion (GO:0045026)9.88483148
5cilium or flagellum-dependent cell motility (GO:0001539)9.69768818
6spermatid development (GO:0007286)9.48108273
7reproduction (GO:0000003)9.05783981
8cilium movement (GO:0003341)8.84897009
9regulation of cilium movement (GO:0003352)8.55190646
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.72960423
11single fertilization (GO:0007338)7.30264473
12sperm capacitation (GO:0048240)7.21807759
13piRNA metabolic process (GO:0034587)7.20567155
14male meiosis (GO:0007140)7.06828566
15negative regulation of inclusion body assembly (GO:0090084)7.02254020
16synaptonemal complex organization (GO:0070193)6.43896693
17response to xenobiotic stimulus (GO:0009410)6.42465115
18left/right axis specification (GO:0070986)6.33921029
19synaptonemal complex assembly (GO:0007130)6.29418105
20organic cation transport (GO:0015695)6.20904502
21spermatogenesis (GO:0007283)6.20647571
22male gamete generation (GO:0048232)6.18137237
23fertilization (GO:0009566)6.10643035
24microtubule depolymerization (GO:0007019)5.87056400
25spermatid nucleus differentiation (GO:0007289)5.80068272
26microtubule bundle formation (GO:0001578)5.79134316
27gamete generation (GO:0007276)5.67137760
28regulation of inclusion body assembly (GO:0090083)5.65813897
29ventricular system development (GO:0021591)5.38226502
30regulation of microtubule-based movement (GO:0060632)5.26994527
31primary alcohol catabolic process (GO:0034310)5.26171910
32germ cell development (GO:0007281)5.24142004
33calcium ion-dependent exocytosis (GO:0017156)5.23853195
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.11983770
35vitamin transmembrane transport (GO:0035461)5.02165083
36seminiferous tubule development (GO:0072520)4.81241347
37cell recognition (GO:0008037)4.74776810
38ethanol metabolic process (GO:0006067)4.62743093
39DNA methylation involved in gamete generation (GO:0043046)4.59363847
40diterpenoid biosynthetic process (GO:0016102)4.46749275
41multicellular organismal reproductive process (GO:0048609)4.45618787
42glycerol ether metabolic process (GO:0006662)4.34634038
43microtubule severing (GO:0051013)4.33222160
44male meiosis I (GO:0007141)4.31213329
45chromosome organization involved in meiosis (GO:0070192)4.15566214
46negative regulation of B cell mediated immunity (GO:0002713)4.14974133
47negative regulation of immunoglobulin mediated immune response (GO:0002890)4.14974133
48retinal rod cell development (GO:0046548)4.11905143
49regulation of interleukin-5 production (GO:0032674)4.11885261
50one-carbon compound transport (GO:0019755)4.09182008
51chromosome condensation (GO:0030261)4.08538163
52tolerance induction (GO:0002507)4.04734562
53negative regulation of humoral immune response (GO:0002921)4.04638259
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.03567886
55regulation of germinal center formation (GO:0002634)4.02762242
56positive regulation of tolerance induction (GO:0002645)4.01970137
57ether metabolic process (GO:0018904)4.00141114
58negative regulation of T cell differentiation in thymus (GO:0033085)3.99077721
59left/right pattern formation (GO:0060972)3.94420337
60DNA packaging (GO:0006323)3.93011181
61meiotic nuclear division (GO:0007126)3.89210357
62pyrimidine-containing compound salvage (GO:0008655)3.83452383
63pyrimidine nucleoside salvage (GO:0043097)3.83452383
64chaperone-mediated protein complex assembly (GO:0051131)3.83262746
65genitalia morphogenesis (GO:0035112)3.77787065
66cell projection assembly (GO:0030031)3.76528486
67pyrimidine-containing compound transmembrane transport (GO:0072531)3.76005004
68monoubiquitinated protein deubiquitination (GO:0035520)3.74058074
69glomerular epithelial cell development (GO:0072310)3.70727112
70lateral ventricle development (GO:0021670)3.69720188
71establishment of planar polarity (GO:0001736)3.68943721
72establishment of tissue polarity (GO:0007164)3.68943721
73sexual reproduction (GO:0019953)3.58019728
74multicellular organismal development (GO:0007275)3.57300652
75regulation of interleukin-13 production (GO:0032656)3.56400840
76cilium morphogenesis (GO:0060271)3.50616599
77gene silencing by RNA (GO:0031047)3.50330794
78protein polyglutamylation (GO:0018095)3.49291623
79negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.43681676
80ethanol oxidation (GO:0006069)3.43154895
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.41087017
82meiosis I (GO:0007127)3.38362693
83mitochondrial DNA replication (GO:0006264)3.33502545
84macroautophagy (GO:0016236)3.33450706
85nucleoside diphosphate phosphorylation (GO:0006165)3.32551799
86GTP biosynthetic process (GO:0006183)3.30985413
87cornea development in camera-type eye (GO:0061303)3.30211881
88lung epithelium development (GO:0060428)3.25610060
89regulation of tolerance induction (GO:0002643)3.25006820
90protein K11-linked deubiquitination (GO:0035871)3.20854335
91single strand break repair (GO:0000012)3.18665628
92retinal cone cell development (GO:0046549)3.18501011
93centriole replication (GO:0007099)3.16317239
94protein refolding (GO:0042026)3.14335077
95retinoic acid metabolic process (GO:0042573)3.14153051
96cilium organization (GO:0044782)3.12666637
97cytoplasmic microtubule organization (GO:0031122)3.10849308
98mitochondrial DNA metabolic process (GO:0032042)3.09915226
99protein localization to cilium (GO:0061512)3.07289331
100centriole assembly (GO:0098534)3.04127638
101establishment of apical/basal cell polarity (GO:0035089)3.03486361
102cilium assembly (GO:0042384)3.02790711
103polyol catabolic process (GO:0046174)3.02233217
104phosphatidylethanolamine biosynthetic process (GO:0006646)3.01559903
105amino-acid betaine transport (GO:0015838)3.00822577
106carnitine transport (GO:0015879)3.00822577
107gene silencing (GO:0016458)2.99941468
108meiotic cell cycle (GO:0051321)2.99923616
109glutathione derivative biosynthetic process (GO:1901687)2.98996146
110glutathione derivative metabolic process (GO:1901685)2.98996146
111axoneme assembly (GO:0035082)2.98339579
112photoreceptor cell maintenance (GO:0045494)2.96258005
113chromatin silencing (GO:0006342)2.93317385
114UTP biosynthetic process (GO:0006228)2.92339369
115exogenous drug catabolic process (GO:0042738)2.91211979
116mitotic sister chromatid cohesion (GO:0007064)2.87821398
117cellular component assembly involved in morphogenesis (GO:0010927)2.87700267
118carnitine transmembrane transport (GO:1902603)2.86518295
119microtubule polymerization or depolymerization (GO:0031109)2.85288118
120microtubule-based movement (GO:0007018)2.82434443
121nucleus organization (GO:0006997)2.81417059
122cellular hyperosmotic response (GO:0071474)2.80080146
123intraciliary transport (GO:0042073)2.76124721
124glycolytic process (GO:0006096)2.75442126
125regulation of spindle checkpoint (GO:0090231)2.75393265
126phosphatidylethanolamine metabolic process (GO:0046337)2.75210423
127production of molecular mediator involved in inflammatory response (GO:0002532)2.74220213
128sequestering of actin monomers (GO:0042989)2.73398262
129histone H3-K36 demethylation (GO:0070544)2.71004593
130O-glycan processing (GO:0016266)2.70078174
131hydrogen peroxide biosynthetic process (GO:0050665)2.69013056
132RNA localization (GO:0006403)2.67509648
133terpenoid biosynthetic process (GO:0016114)2.67292195
134retinol metabolic process (GO:0042572)2.67059103
135nucleoside salvage (GO:0043174)2.66790868
136lateral sprouting from an epithelium (GO:0060601)2.65655004
137positive regulation of protein sumoylation (GO:0033235)2.64593885
138positive regulation of chemokine secretion (GO:0090197)2.64419955
139UTP metabolic process (GO:0046051)2.64244787
140negative regulation of protein oligomerization (GO:0032460)2.61018761
141regulation of interleukin-6 biosynthetic process (GO:0045408)2.59131421
142reactive oxygen species biosynthetic process (GO:1903409)2.53306303
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.52046937
144establishment or maintenance of monopolar cell polarity (GO:0061339)2.51318331
145establishment of monopolar cell polarity (GO:0061162)2.51318331
146determination of left/right symmetry (GO:0007368)2.50940284
147regulation of cilium assembly (GO:1902017)2.48480471
148response to nitrosative stress (GO:0051409)2.48068641
149drug catabolic process (GO:0042737)2.43650684
150primary alcohol metabolic process (GO:0034308)2.43283861
151phosphatidylcholine biosynthetic process (GO:0006656)2.41048634
152phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.40106433
153microtubule-based process (GO:0007017)2.39848173
154determination of bilateral symmetry (GO:0009855)2.39655868
155quaternary ammonium group transport (GO:0015697)2.38206722
156negative regulation of adaptive immune response (GO:0002820)2.35139782
157specification of symmetry (GO:0009799)2.33440921
158sperm motility (GO:0030317)13.3344310
159fusion of sperm to egg plasma membrane (GO:0007342)13.0594813
160cell wall macromolecule catabolic process (GO:0016998)12.5065236
161cell wall macromolecule metabolic process (GO:0044036)12.5065236
162acrosome assembly (GO:0001675)11.2177964
163acrosome reaction (GO:0007340)11.0668508
164sperm-egg recognition (GO:0035036)11.0060410
165multicellular organism reproduction (GO:0032504)10.6228805
166axonemal dynein complex assembly (GO:0070286)10.3644524
167epithelial cilium movement (GO:0003351)10.2296649

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.73825956
2EZH2_22144423_ChIP-Seq_EOC_Human3.36127911
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.24515930
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.24047532
5DROSHA_22980978_ChIP-Seq_HELA_Human2.99158323
6FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.94600895
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66995430
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61765955
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.49385574
10VDR_22108803_ChIP-Seq_LS180_Human2.46177778
11AR_21572438_ChIP-Seq_LNCaP_Human2.34531684
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.27008547
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.13549613
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.09109172
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.2879177
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.94673194
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92107647
18AHR_22903824_ChIP-Seq_MCF-7_Human1.91809595
19TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.84269641
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81040418
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.79864798
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77456206
23ZNF274_21170338_ChIP-Seq_K562_Hela1.77390251
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76630363
25SMRT_27268052_Chip-Seq_Bcells_Human1.76531086
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76306249
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.75446215
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72784910
29STAT1_17558387_ChIP-Seq_HELA_Human1.70604243
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63424807
31ELK4_26923725_Chip-Seq_MESODERM_Mouse1.59640005
32KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.59603831
33TP63_23658742_ChIP-Seq_EP156T_Human1.59353093
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.59316954
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.58480839
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.56539738
37VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.54081943
38GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53742830
39MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.53072224
40TAF15_26573619_Chip-Seq_HEK293_Human1.50305276
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.50261059
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.50216026
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49242431
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47409985
45FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46569518
46RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46178063
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43909237
48CBP_20019798_ChIP-Seq_JUKART_Human1.43909237
49SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40645051
50SMAD4_21799915_ChIP-Seq_A2780_Human1.39240942
51KDM2B_26808549_Chip-Seq_REH_Human1.36541725
52* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36481990
53TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.36190520
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35557864
55SMC4_20622854_ChIP-Seq_HELA_Human1.35427898
56TAL1_26923725_Chip-Seq_HPCs_Mouse1.33458848
57ETV1_20927104_ChIP-Seq_GIST48_Human1.33434257
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33292218
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32447422
60GATA1_22025678_ChIP-Seq_K562_Human1.32105955
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.31532583
62KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30752534
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.30581079
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.30242859
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.30242728
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.29957425
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29354346
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28093961
69GATA3_21867929_ChIP-Seq_CD8_Mouse1.27986517
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27346795
71RUNX_20019798_ChIP-Seq_JUKART_Human1.27179033
72* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26999838
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.26457017
74VDR_24787735_ChIP-Seq_THP-1_Human1.25681651
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.25668883
76STAT3_23295773_ChIP-Seq_U87_Human1.25624835
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25442448
78ER_23166858_ChIP-Seq_MCF-7_Human1.24698816
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24540745
80* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24298361
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23953335
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22654732
83STAT1_20625510_ChIP-Seq_HELA_Human1.21953017
84LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.20808753
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.19772874
86RUNX1_27514584_Chip-Seq_MCF-7_Human1.19321942
87OCT4_18555785_Chip-Seq_ESCs_Mouse1.19202811
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19075118
89P53_21459846_ChIP-Seq_SAOS-2_Human1.18841865
90* HNFA_21074721_ChIP-Seq_CACO-2_Human1.18406902
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.18329583
92GATA1_19941826_ChIP-Seq_K562_Human1.18325293
93P53_22387025_ChIP-Seq_ESCs_Mouse1.18275460
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.17223569
95RBPJ_21746931_ChIP-Seq_IB4_Human1.16971167
96GATA3_21867929_ChIP-Seq_TH1_Mouse1.16858068
97RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13404155
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.13183772
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12867199
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12136961
101* TP53_18474530_ChIP-ChIP_U2OS_Human1.12033014
102FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12007984
103P300_18555785_Chip-Seq_ESCs_Mouse1.11517251
104KLF5_25053715_ChIP-Seq_YYC3_Human1.11430901
105ERG_20517297_ChIP-Seq_VCAP_Human1.11367228
106* PHF8_20622853_ChIP-Seq_HELA_Human1.11312280
107TP53_16413492_ChIP-PET_HCT116_Human1.10968096
108TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10869305
109PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10833499
110GATA6_21074721_ChIP-Seq_CACO-2_Human1.10829090
111REST_21632747_ChIP-Seq_MESCs_Mouse1.10267897
112GATA1_19941827_ChIP-Seq_MEL86_Mouse1.09900494
113BCAT_22108803_ChIP-Seq_LS180_Human1.09886799
114FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09861527
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.09669432
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09313576
117CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08796463
118CBX2_22325352_ChIP-Seq_293T-Rex_Human1.07666577
119CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07609647
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07553285
121GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07399726
122GF1_26923725_Chip-Seq_HPCs_Mouse1.07234000
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06897344
124SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06800399
125KLF4_18555785_Chip-Seq_ESCs_Mouse1.06516413
126* NFYA_21822215_ChIP-Seq_K562_Human1.06212206
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05966736
128ESRRB_18555785_Chip-Seq_ESCs_Mouse1.04916440
129RUNX2_22187159_ChIP-Seq_PCA_Human1.04239341
130TP63_22573176_ChIP-Seq_HFKS_Human1.03977101
131SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03729317
132PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03213388
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.03203724
134OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02388113
135RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01862646
136TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01441194
137FOXA1_25552417_ChIP-Seq_VCAP_Human1.01126049
138CEBPB_22108803_ChIP-Seq_LS180_Human1.00938249
139EZH2_27294783_Chip-Seq_NPCs_Mouse1.00884191
140ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00618910
141ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00277464
142EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00121325
143SOX9_26525672_Chip-Seq_HEART_Mouse1.00084210
144Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99974711
145FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99114981
146FOXA1_25329375_ChIP-Seq_VCAP_Human0.99114981
147* NFYB_21822215_ChIP-Seq_K562_Human0.99049819
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99022461
149CDX2_22108803_ChIP-Seq_LS180_Human0.98173158
150* TBL1_22424771_ChIP-Seq_293T_Human0.98065566
151RNF2_27304074_Chip-Seq_NSC_Mouse0.97797569
152TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97180194
153GATA2_19941826_ChIP-Seq_K562_Human0.96700878
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96449161
155TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96338889
156POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96338889
157PU1_27457419_Chip-Seq_LIVER_Mouse0.96300544
158SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96089719
159STAT3_18555785_Chip-Seq_ESCs_Mouse0.95905433
160SMAD3_21741376_ChIP-Seq_ESCs_Human0.95519119
161CTCF_20526341_ChIP-Seq_ESCs_Human0.95474926
162SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95449238
163PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95426036
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95024502
165P300_27268052_Chip-Seq_Bcells_Human0.94957018
166SOX2_18555785_Chip-Seq_ESCs_Mouse0.94572263
167IRF8_27001747_Chip-Seq_BMDM_Mouse0.93815414
168GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93722097
169SCL_19346495_ChIP-Seq_HPC-7_Human0.93009097
170MYC_27129775_Chip-Seq_CORNEA_Mouse0.92830153
171SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92583504
172SPI1_26923725_Chip-Seq_HPCs_Mouse0.92519838
173GATA3_27048872_Chip-Seq_THYMUS_Human0.92064418
174ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91674364
175MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91503645
176* TCF4_22108803_ChIP-Seq_LS180_Human0.91493630
177CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91318930
178GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90834415
179E2F1_18555785_Chip-Seq_ESCs_Mouse0.90074260
180RXRA_24833708_ChIP-Seq_LIVER_Mouse0.90006972
181CTCF_18555785_Chip-Seq_ESCs_Mouse0.88518933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.71642215
2MP0001929_abnormal_gametogenesis5.20377841
3MP0008877_abnormal_DNA_methylation5.18620186
4MP0002277_abnormal_respiratory_mucosa3.22960335
5MP0004043_abnormal_pH_regulation3.16795850
6MP0002161_abnormal_fertility/fecundity3.09848239
7MP0002210_abnormal_sex_determination3.03576367
8MP0001145_abnormal_male_reproductive2.64091520
9MP0000383_abnormal_hair_follicle2.63958883
10MP0005083_abnormal_biliary_tract2.60152361
11MP0000678_abnormal_parathyroid_gland2.46485364
12MP0003787_abnormal_imprinting2.32896629
13MP0000653_abnormal_sex_gland2.28912409
14MP0009780_abnormal_chondrocyte_physiolo2.07256037
15MP0010678_abnormal_skin_adnexa2.03896823
16MP0002168_other_aberrant_phenotype2.03813352
17MP0005670_abnormal_white_adipose2.01686522
18MP0005410_abnormal_fertilization15.5477873
19MP0002282_abnormal_trachea_morphology1.86406690
20MP0010030_abnormal_orbit_morphology1.85936884
21MP0002653_abnormal_ependyma_morphology1.80646469
22MP0008995_early_reproductive_senescence1.78719191
23MP0003656_abnormal_erythrocyte_physiolo1.77838346
24MP0003303_peritoneal_inflammation1.71405604
25MP0005248_abnormal_Harderian_gland1.68565851
26MP0005623_abnormal_meninges_morphology1.63650648
27MP0002160_abnormal_reproductive_system1.57731909
28MP0000566_synostosis1.51893751
29MP0005310_abnormal_salivary_gland1.44242741
30MP0002132_abnormal_respiratory_system1.42376081
31MP0000465_gastrointestinal_hemorrhage1.36777633
32MP0005387_immune_system_phenotype1.34568379
33MP0001790_abnormal_immune_system1.34568379
34MP0004233_abnormal_muscle_weight1.32219805
35MP0002136_abnormal_kidney_physiology1.31190639
36MP0008789_abnormal_olfactory_epithelium1.30489227
37MP0009643_abnormal_urine_homeostasis1.27785571
38MP0010155_abnormal_intestine_physiology1.23394336
39MP0006035_abnormal_mitochondrial_morpho1.23094186
40MP0003045_fibrosis1.21875298
41MP0003763_abnormal_thymus_physiology1.20674131
42MP0005395_other_phenotype1.18568403
43MP0000534_abnormal_ureter_morphology1.17075053
44MP0002971_abnormal_brown_adipose1.15101918
45MP0005647_abnormal_sex_gland1.15085917
46MP0005025_abnormal_response_to1.12270967
47MP0001800_abnormal_humoral_immune1.11307071
48MP0003011_delayed_dark_adaptation1.07888275
49MP0004883_abnormal_blood_vessel1.06464833
50MP0009765_abnormal_xenobiotic_induced1.06274545
51MP0001765_abnormal_ion_homeostasis1.04235749
52MP0003632_abnormal_nervous_system1.01087115
53MP0005164_abnormal_response_to0.99276658
54MP0006036_abnormal_mitochondrial_physio0.97082616
55MP0002254_reproductive_system_inflammat0.96615403
56MP0005389_reproductive_system_phenotype0.96448298
57MP0005165_increased_susceptibility_to0.95636132
58MP0004484_altered_response_of0.95045762
59MP0001485_abnormal_pinna_reflex0.94653225
60MP0000681_abnormal_thyroid_gland0.93263824
61MP0003866_abnormal_defecation0.93198833
62MP0001346_abnormal_lacrimal_gland0.89133808
63MP0009046_muscle_twitch0.88132127
64MP0009785_altered_susceptibility_to0.87886097
65MP0002723_abnormal_immune_serum0.84961799
66MP0001984_abnormal_olfaction0.84182171
67MP0001664_abnormal_digestion0.82847361
68MP0002419_abnormal_innate_immunity0.82497407
69MP0002452_abnormal_antigen_presenting0.82219301
70MP0005408_hypopigmentation0.82214010
71MP0000569_abnormal_digit_pigmentation0.81150463
72MP0001663_abnormal_digestive_system0.78850502
73MP0002135_abnormal_kidney_morphology0.78098381
74MP0005464_abnormal_platelet_physiology0.77610011
75MP0004019_abnormal_vitamin_homeostasis0.77543377
76MP0003631_nervous_system_phenotype0.77416374
77MP0008004_abnormal_stomach_pH0.76110197
78MP0002420_abnormal_adaptive_immunity0.74926003
79MP0009379_abnormal_foot_pigmentation0.74807604
80MP0002229_neurodegeneration0.74176809
81MP0001845_abnormal_inflammatory_respons0.73977862
82MP0003646_muscle_fatigue0.73868192
83MP0001819_abnormal_immune_cell0.73763224
84MP0001324_abnormal_eye_pigmentation0.69696700
85MP0002928_abnormal_bile_duct0.68932203
86MP0005000_abnormal_immune_tolerance0.68652531
87MP0002249_abnormal_larynx_morphology0.68561014
88MP0004264_abnormal_extraembryonic_tissu0.68488259
89MP0000249_abnormal_blood_vessel0.66889069
90MP0005671_abnormal_response_to0.66098077
91MP0005166_decreased_susceptibility_to0.65027013
92MP0003195_calcinosis0.64131076
93MP0004130_abnormal_muscle_cell0.63414713
94MP0008058_abnormal_DNA_repair0.62212034
95MP0005376_homeostasis/metabolism_phenot0.62032051
96MP0000613_abnormal_salivary_gland0.61717178
97MP0002734_abnormal_mechanical_nocicepti0.61197568
98MP0000716_abnormal_immune_system0.61104145
99MP0002148_abnormal_hypersensitivity_rea0.61071137
100MP0002234_abnormal_pharynx_morphology0.60125998
101MP0005085_abnormal_gallbladder_physiolo0.58897238
102MP0005535_abnormal_body_temperature0.58476303
103MP0009763_increased_sensitivity_to0.58323466
104MP0004808_abnormal_hematopoietic_stem0.58281048
105MP0005394_taste/olfaction_phenotype0.57814927
106MP0005499_abnormal_olfactory_system0.57814927
107MP0003075_altered_response_to0.57146438
108MP0002735_abnormal_chemical_nociception0.56338880
109MP0003633_abnormal_nervous_system0.56322372
110MP0002139_abnormal_hepatobiliary_system0.56253977
111MP0001963_abnormal_hearing_physiology0.55672831
112MP0005646_abnormal_pituitary_gland0.54526260
113MP0010094_abnormal_chromosome_stability0.54186517
114MP0002736_abnormal_nociception_after0.50168348
115MP0005397_hematopoietic_system_phenotyp0.49812870
116MP0001545_abnormal_hematopoietic_system0.49812870
117MP0005253_abnormal_eye_physiology0.48637113
118MP0005636_abnormal_mineral_homeostasis0.48089417
119MP0003121_genomic_imprinting0.46883613
120MP0005551_abnormal_eye_electrophysiolog0.46143189
121MP0003942_abnormal_urinary_system0.43790875
122MP0009278_abnormal_bone_marrow0.43743640
123MP0003878_abnormal_ear_physiology0.41811585
124MP0005377_hearing/vestibular/ear_phenot0.41811585
125MP0003786_premature_aging0.41198584
126MP0003329_amyloid_beta_deposits0.39660469
127MP0002405_respiratory_system_inflammati0.39383773
128MP0010630_abnormal_cardiac_muscle0.38409968
129MP0003115_abnormal_respiratory_system0.37884199
130MP0002909_abnormal_adrenal_gland0.37004330
131MP0003699_abnormal_female_reproductive0.35835066
132MP0001764_abnormal_homeostasis0.34489932
133MP0003567_abnormal_fetal_cardiomyocyte0.34360505
134MP0005451_abnormal_body_composition0.32948840
135MP0000955_abnormal_spinal_cord0.32030839
136MP0006054_spinal_hemorrhage0.31811141
137MP0005391_vision/eye_phenotype0.31785503
138MP0010307_abnormal_tumor_latency0.31303190
139MP0003252_abnormal_bile_duct0.30185965
140MP0003724_increased_susceptibility_to0.29828145
141MP0000604_amyloidosis0.28386120
142MP0008875_abnormal_xenobiotic_pharmacok0.28024276
143MP0001119_abnormal_female_reproductive0.27391733
144MP0002970_abnormal_white_adipose0.27341000
145MP0006082_CNS_inflammation0.26407536
146MP0001919_abnormal_reproductive_system0.26179014
147MP0009115_abnormal_fat_cell0.26176142
148MP0001293_anophthalmia0.26102613
149MP0004133_heterotaxia0.25518030
150MP0004036_abnormal_muscle_relaxation0.24997099
151MP0005195_abnormal_posterior_eye0.24139747
152MP0002152_abnormal_brain_morphology0.23147894
153MP0001968_abnormal_touch/_nociception0.21942570
154MP0008057_abnormal_DNA_replication0.20776293
155MP0005388_respiratory_system_phenotype0.20296581
156MP0002133_abnormal_respiratory_system0.20296581
157MP0001986_abnormal_taste_sensitivity0.19541128
158MP0001835_abnormal_antigen_presentation0.17352941
159MP0005174_abnormal_tail_pigmentation0.17318418
160MP0001727_abnormal_embryo_implantation0.17065593
161MP0004087_abnormal_muscle_fiber0.16704609
162MP0006072_abnormal_retinal_apoptosis0.15411758
163MP0003959_abnormal_lean_body0.15072556
164MP0002169_no_abnormal_phenotype0.14149653

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.20581919
2Abnormal respiratory motile cilium morphology (HP:0005938)8.79273388
3Abnormal respiratory epithelium morphology (HP:0012253)8.79273388
4Rhinitis (HP:0012384)7.51115571
5Abnormal ciliary motility (HP:0012262)7.46237557
6Chronic bronchitis (HP:0004469)6.99039148
7Infertility (HP:0000789)6.02643430
8Nasal polyposis (HP:0100582)5.71160571
9Facial diplegia (HP:0001349)5.66581443
10Progressive inability to walk (HP:0002505)5.41214760
11Abnormality of the nasal mucosa (HP:0000433)4.71324614
12Bronchitis (HP:0012387)4.51798408
13Bronchiectasis (HP:0002110)4.50484433
14Male infertility (HP:0003251)4.15434770
15Recurrent sinusitis (HP:0011108)3.61507852
16Nephronophthisis (HP:0000090)3.43445593
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.41298853
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.41298853
19Ragged-red muscle fibers (HP:0003200)3.29870487
20Recurrent otitis media (HP:0000403)3.27206279
21Abnormal spermatogenesis (HP:0008669)3.19078195
22Occipital encephalocele (HP:0002085)3.12406325
23True hermaphroditism (HP:0010459)3.10963798
24Chronic otitis media (HP:0000389)3.09978989
25Inability to walk (HP:0002540)2.97651350
26Hyperactive renin-angiotensin system (HP:0000841)2.93275258
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.89975787
28Absent frontal sinuses (HP:0002688)2.87752562
29Recurrent bronchitis (HP:0002837)2.86971248
30Atelectasis (HP:0100750)2.81742899
31Tubulointerstitial nephritis (HP:0001970)2.76465913
32Abnormality of the heme biosynthetic pathway (HP:0010472)2.73355578
33Pancreatic cysts (HP:0001737)2.66997036
34Abnormality of the renal medulla (HP:0100957)2.66542629
35Delayed gross motor development (HP:0002194)2.58617975
36Cystic liver disease (HP:0006706)2.51699607
37Weak cry (HP:0001612)2.44102247
38Dyschromatopsia (HP:0007641)2.32304237
39Abnormality of dentin (HP:0010299)2.30411800
40Taurodontia (HP:0000679)2.30403557
41Abnormality of permanent molar morphology (HP:0011071)2.30403557
42Abnormality of the dental root (HP:0006486)2.30403557
43Abnormality of midbrain morphology (HP:0002418)2.27599904
44Molar tooth sign on MRI (HP:0002419)2.27599904
45Tubulointerstitial abnormality (HP:0001969)2.26770361
46Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.23719116
47Azoospermia (HP:0000027)2.17255767
48Abnormality of molar morphology (HP:0011070)2.13018979
49Abnormality of molar (HP:0011077)2.13018979
50Abnormality of the dental pulp (HP:0006479)2.11763876
51Impulsivity (HP:0100710)2.10196405
52Hyperkalemia (HP:0002153)2.09162137
53Medial flaring of the eyebrow (HP:0010747)2.05100282
54Decreased circulating renin level (HP:0003351)2.04596738
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.5565566
56Absent/shortened dynein arms (HP:0200106)12.1121085
57Dynein arm defect of respiratory motile cilia (HP:0012255)12.1121085
58Gonadotropin excess (HP:0000837)1.99320779
59Bell-shaped thorax (HP:0001591)1.92783144
60Tubular atrophy (HP:0000092)1.90681604
61Abnormal rod and cone electroretinograms (HP:0008323)1.89879974
62Male pseudohermaphroditism (HP:0000037)1.83696361
63Abnormal pancreas size (HP:0012094)1.83329807
64Gowers sign (HP:0003391)1.82733610
65Decreased central vision (HP:0007663)1.82549332
66Abnormality of the frontal sinuses (HP:0002687)1.80873088
67Tubulointerstitial fibrosis (HP:0005576)1.80300795
68Chronic sinusitis (HP:0011109)1.75917241
69Renal salt wasting (HP:0000127)1.74818685
70Anencephaly (HP:0002323)1.74176970
71Annular pancreas (HP:0001734)1.73975141
72Hypercholesterolemia (HP:0003124)1.70031791
73Oculomotor apraxia (HP:0000657)1.69490403
74Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.67811122
75Cone-rod dystrophy (HP:0000548)1.66872424
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.66732639
77Facial cleft (HP:0002006)1.66563684
78Retrobulbar optic neuritis (HP:0100654)1.66235609
79Optic neuritis (HP:0100653)1.66235609
80Abnormal gallbladder physiology (HP:0012438)1.65428443
81Cholecystitis (HP:0001082)1.65428443
82Asplenia (HP:0001746)1.64387512
83Hemorrhage of the eye (HP:0011885)1.63427943
84Abnormality of chloride homeostasis (HP:0011422)1.59901030
85Postaxial foot polydactyly (HP:0001830)1.59707564
86Small hand (HP:0200055)1.58312080
87Aplasia/Hypoplasia of the spleen (HP:0010451)1.57006696
88Congenital hepatic fibrosis (HP:0002612)1.56676308
89Generalized amyotrophy (HP:0003700)1.54838734
90Aplasia/Hypoplasia of the lens (HP:0008063)1.53840389
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.52444007
92Stage 5 chronic kidney disease (HP:0003774)1.51729580
93Gait imbalance (HP:0002141)1.50766211
94Constricted visual fields (HP:0001133)1.50665865
95Volvulus (HP:0002580)1.48231777
96Choroideremia (HP:0001139)1.45645189
97Hypokalemic alkalosis (HP:0001949)1.44694896
98EMG: myopathic abnormalities (HP:0003458)1.44011754
99Hyperaldosteronism (HP:0000859)1.43979943
100Bony spicule pigmentary retinopathy (HP:0007737)1.43890384
101Spastic tetraparesis (HP:0001285)1.41879113
102Abnormal biliary tract physiology (HP:0012439)1.41823312
103Bile duct proliferation (HP:0001408)1.41823312
104Short ribs (HP:0000773)1.41786806
105Sclerocornea (HP:0000647)1.41286751
106Furrowed tongue (HP:0000221)1.41058700
107Abnormality of renin-angiotensin system (HP:0000847)1.38605278
108Orchitis (HP:0100796)1.37879722
109Hypochromic microcytic anemia (HP:0004840)1.37258928
110Cleft eyelid (HP:0000625)1.37064727
111Nephrogenic diabetes insipidus (HP:0009806)1.36559962
112Abnormal drinking behavior (HP:0030082)1.35992883
113Polydipsia (HP:0001959)1.35992883
114Abnormality of the renal cortex (HP:0011035)1.35948932
115Truncal obesity (HP:0001956)1.35308778
116Chronic hepatic failure (HP:0100626)1.33983525
117Recurrent pneumonia (HP:0006532)1.31210920
118Nephropathy (HP:0000112)1.30733285
119Abnormality of renal excretion (HP:0011036)1.29933598
120Median cleft lip (HP:0000161)1.29815054
121Fibular hypoplasia (HP:0003038)1.28062251
122Pancreatic fibrosis (HP:0100732)1.27994931
123Abnormality of macular pigmentation (HP:0008002)1.27778532
124Poor coordination (HP:0002370)1.27684496
125Abnormality of the fingertips (HP:0001211)1.26345128
126Macular degeneration (HP:0000608)1.25370978
127Postaxial hand polydactyly (HP:0001162)1.25120406
128Heterotopia (HP:0002282)1.24634747
129Supernumerary spleens (HP:0009799)1.23213054
130Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.21589657
131Central scotoma (HP:0000603)1.19908693
132Congenital primary aphakia (HP:0007707)1.19858771
133Abnormal lung lobation (HP:0002101)1.19293665
134Lip pit (HP:0100267)1.14810140
135Preaxial hand polydactyly (HP:0001177)1.12832662
136Attenuation of retinal blood vessels (HP:0007843)1.09061311
137Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.08056126
138Vaginal atresia (HP:0000148)1.07174386
139Hyponatremia (HP:0002902)1.07046513
140Genital tract atresia (HP:0001827)1.06556279
141Short thorax (HP:0010306)1.03947334
142Glucose intolerance (HP:0000833)1.03091312
143Portal hypertension (HP:0001409)1.00535528
144Recurrent bacterial skin infections (HP:0005406)0.96728793
145Severe visual impairment (HP:0001141)0.96500671
146Retinitis pigmentosa (HP:0000510)0.96047901
147Recurrent gram-negative bacterial infections (HP:0005420)0.95331961
148Macroorchidism (HP:0000053)0.95157856
149Abnormality of the distal phalanges of the toes (HP:0010182)0.95134464
150Fetal akinesia sequence (HP:0001989)0.91537458
151Abnormality of the hepatic vasculature (HP:0006707)0.91066478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.23833912
2PDK48.23833912
3TESK15.40811304
4PDK25.24108023
5PRKD34.56780283
6ICK4.22566849
7MST43.99294185
8SMG12.75639557
9EPHA22.65255843
10DYRK1B2.63364915
11WNK42.01646816
12PTK2B1.99427035
13MAP3K21.92800340
14PNCK1.92228622
15CSK1.85337344
16STK391.81071705
17MAPKAPK31.70374441
18FRK1.64212970
19MAPK151.57242053
20STK381.39712008
21PDK11.37755091
22PBK1.28683909
23NEK21.28066813
24MAP3K31.26243880
25TYK21.25312884
26NME11.22795784
27MAP3K71.21277465
28TLK11.18572710
29STK241.15990102
30ERBB21.11922102
31FGFR31.09794641
32MAP3K61.06030630
33INSRR1.05586409
34TXK1.00059971
35TBK11.00003259
36TRPM70.99162138
37WNK10.98542246
38MAP4K20.98089852
39BCR0.97986916
40CDK60.95280817
41MAP3K50.94959129
42BRSK20.93527647
43JAK30.93230404
44ACVR1B0.89021792
45GRK60.88973681
46LRRK20.87429688
47DYRK30.86299043
48MAP2K40.84767753
49RIPK40.79752469
50ADRBK10.79408319
51PDPK10.78868734
52TAOK30.78522455
53MST1R0.76058976
54DYRK1A0.75182231
55STK30.70255781
56SIK20.69917909
57BMPR20.69067415
58IRAK10.67389805
59CDC42BPA0.66334426
60PRKG20.64886548
61SIK10.64265905
62TEC0.62247114
63MAP2K60.61803220
64KIT0.60278586
65MAPKAPK50.55571266
66RPS6KA20.55501443
67SGK20.54923401
68LYN0.53378187
69LMTK20.52064969
70SGK10.52016093
71PASK0.51575263
72FYN0.51561744
73MAP2K30.51365810
74STK38L0.51233490
75CAMK1G0.50072539
76CCNB10.48455190
77HCK0.48415984
78MAP3K40.48156137
79CAMKK20.47661185
80TTK0.46353692
81CAMKK10.45870773
82RET0.45295835
83LATS10.44878057
84GRK10.43558192
85MELK0.42309045
86CHEK20.41541077
87RPS6KA60.41355282
88ITK0.40942564
89MAPK70.40842653
90RPS6KA50.39772569
91PAK40.38924950
92AURKA0.38568193
93TYRO30.38279923
94EPHB10.37617744
95LCK0.37509434
96RPS6KC10.35963609
97RPS6KL10.35963609
98CDK40.35898271
99CAMK10.35156555
100MAP4K10.34429097
101CHEK10.33483905
102PRKCQ0.33027474
103EPHA30.32958686
104PAK20.32908172
105IRAK40.31967922
106CSF1R0.31219474
107BRSK10.30279745
108NEK60.30209479
109UHMK10.28499297
110PRKCG0.27833806
111PINK10.27285147
112TESK20.26409439
113ZAP700.25768408
114RPS6KB10.25570171
115IRAK20.24976362
116ATR0.24254440
117PAK10.23967335
118PLK40.22994871
119SGK30.22503768
120PIM10.21339454
121EEF2K0.21169031
122CDK120.20016275
123PKN10.19642627
124NTRK20.18384836
125MUSK0.18079573
126MYLK0.16279318
127RPS6KB20.15706523
128ATM0.15423672
129EGFR0.15309514
130PRKAA10.15304461
131RPS6KA10.13383023
132MAPK80.12745640
133PRKG10.12676728
134SYK0.12453191
135MTOR0.12157067
136PDGFRB0.10299377
137WEE10.09370429
138PRKAA20.09249916
139MARK30.08685690
140CHUK0.08569084
141PIK3CG0.07747685
142CSNK1D0.07614855
143GSK3B0.07225014
144PRKCD0.07074295
145STK100.06896574
146CSNK2A10.06578274
147IKBKE0.06487841
148AURKB0.06399466
149MARK20.05656534
150MAPK120.05603229
151PRKACG0.05574242
152MAP3K120.04833290
153MAPK140.04649122
154MAPK10.04636054
155PRKD10.04067354
156CDK20.03965472
157STK40.03820334
158CSNK2A20.03186239
159JAK10.03081376
160BLK0.02855125
161BTK0.01922638

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004504.38043865
2Fatty acid biosynthesis_Homo sapiens_hsa000614.07456506
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.93555518
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.34881391
5Phenylalanine metabolism_Homo sapiens_hsa003603.28494059
6Linoleic acid metabolism_Homo sapiens_hsa005913.21614691
7Histidine metabolism_Homo sapiens_hsa003403.10222557
8Vitamin B6 metabolism_Homo sapiens_hsa007503.02561390
9Pyruvate metabolism_Homo sapiens_hsa006202.73318492
10Retinol metabolism_Homo sapiens_hsa008302.53296148
11Glucagon signaling pathway_Homo sapiens_hsa049222.49407199
12Tyrosine metabolism_Homo sapiens_hsa003502.42497420
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.41571541
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.37476818
15Propanoate metabolism_Homo sapiens_hsa006402.32422193
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.17444591
17Drug metabolism - other enzymes_Homo sapiens_hsa009832.02060439
18Pyrimidine metabolism_Homo sapiens_hsa002401.99801491
19PPAR signaling pathway_Homo sapiens_hsa033201.84995079
20beta-Alanine metabolism_Homo sapiens_hsa004101.83201523
21Allograft rejection_Homo sapiens_hsa053301.80745155
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.79844888
23Basal transcription factors_Homo sapiens_hsa030221.77818041
24Glycerophospholipid metabolism_Homo sapiens_hsa005641.75014313
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69483918
26Glycerolipid metabolism_Homo sapiens_hsa005611.68582435
27Graft-versus-host disease_Homo sapiens_hsa053321.64028959
28Autoimmune thyroid disease_Homo sapiens_hsa053201.60275396
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.58424878
30Ether lipid metabolism_Homo sapiens_hsa005651.58285966
31Caffeine metabolism_Homo sapiens_hsa002321.58245038
32Type I diabetes mellitus_Homo sapiens_hsa049401.49213019
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46651765
34Pentose phosphate pathway_Homo sapiens_hsa000301.45892094
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.45635051
36Taste transduction_Homo sapiens_hsa047421.45185875
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.44899408
38Asthma_Homo sapiens_hsa053101.43156609
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.41002355
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38364514
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37966526
42Fructose and mannose metabolism_Homo sapiens_hsa000511.37493517
43Dorso-ventral axis formation_Homo sapiens_hsa043201.33271937
44Hematopoietic cell lineage_Homo sapiens_hsa046401.32851269
45Oocyte meiosis_Homo sapiens_hsa041141.30552069
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29920239
47Mineral absorption_Homo sapiens_hsa049781.28917060
48Phototransduction_Homo sapiens_hsa047441.26184643
49Staphylococcus aureus infection_Homo sapiens_hsa051501.24853905
50Amphetamine addiction_Homo sapiens_hsa050311.19532430
51Collecting duct acid secretion_Homo sapiens_hsa049661.18860045
52Fanconi anemia pathway_Homo sapiens_hsa034601.16704084
53Purine metabolism_Homo sapiens_hsa002301.16024557
54Fat digestion and absorption_Homo sapiens_hsa049751.12656233
55Arachidonic acid metabolism_Homo sapiens_hsa005901.09559772
56Fatty acid degradation_Homo sapiens_hsa000711.08535603
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07613232
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06344476
59Antigen processing and presentation_Homo sapiens_hsa046121.06199748
60Fatty acid metabolism_Homo sapiens_hsa012121.05249412
61Sphingolipid metabolism_Homo sapiens_hsa006001.04523081
62ABC transporters_Homo sapiens_hsa020101.04077119
63Renin secretion_Homo sapiens_hsa049240.97454292
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.97192636
65Leishmaniasis_Homo sapiens_hsa051400.96483388
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94827618
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.93773652
68Cardiac muscle contraction_Homo sapiens_hsa042600.93433700
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91839103
70Legionellosis_Homo sapiens_hsa051340.87963170
71Tight junction_Homo sapiens_hsa045300.87855866
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.86909623
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86612454
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.85638590
75Starch and sucrose metabolism_Homo sapiens_hsa005000.85197166
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84419351
77Peroxisome_Homo sapiens_hsa041460.82788899
78Huntingtons disease_Homo sapiens_hsa050160.81595027
79Tuberculosis_Homo sapiens_hsa051520.80339170
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80066748
81Choline metabolism in cancer_Homo sapiens_hsa052310.79045256
82Carbon metabolism_Homo sapiens_hsa012000.77497241
83Hedgehog signaling pathway_Homo sapiens_hsa043400.77172630
84Protein digestion and absorption_Homo sapiens_hsa049740.76910416
85Insulin secretion_Homo sapiens_hsa049110.74921128
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72047049
87Bile secretion_Homo sapiens_hsa049760.70573509
88Inositol phosphate metabolism_Homo sapiens_hsa005620.70513012
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68899957
90Thyroid hormone synthesis_Homo sapiens_hsa049180.64733007
91Chemical carcinogenesis_Homo sapiens_hsa052040.64446902
92Estrogen signaling pathway_Homo sapiens_hsa049150.63430667
93Sulfur metabolism_Homo sapiens_hsa009200.63416759
94Circadian rhythm_Homo sapiens_hsa047100.63015492
95Systemic lupus erythematosus_Homo sapiens_hsa053220.62481073
96Glutathione metabolism_Homo sapiens_hsa004800.62215168
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61801244
98Non-homologous end-joining_Homo sapiens_hsa034500.61691364
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61504541
100RNA transport_Homo sapiens_hsa030130.60378063
101Hepatitis C_Homo sapiens_hsa051600.58185392
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57910619
103Primary immunodeficiency_Homo sapiens_hsa053400.56241060
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54608216
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.51606797
106Renin-angiotensin system_Homo sapiens_hsa046140.51426804
107B cell receptor signaling pathway_Homo sapiens_hsa046620.50652214
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49765246
109Gap junction_Homo sapiens_hsa045400.48933084
110Olfactory transduction_Homo sapiens_hsa047400.48581363
111Pancreatic secretion_Homo sapiens_hsa049720.47559298
112mRNA surveillance pathway_Homo sapiens_hsa030150.46088984
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45688561
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45513466
115Viral myocarditis_Homo sapiens_hsa054160.45265461
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.43755823
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43682838
118Malaria_Homo sapiens_hsa051440.42486766
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41651242
120Nitrogen metabolism_Homo sapiens_hsa009100.41082502
121Calcium signaling pathway_Homo sapiens_hsa040200.40734724
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.40668631
123Biosynthesis of amino acids_Homo sapiens_hsa012300.40078943
124Complement and coagulation cascades_Homo sapiens_hsa046100.39821122
125Long-term potentiation_Homo sapiens_hsa047200.39019347
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38939778
127Nicotine addiction_Homo sapiens_hsa050330.38867997
128Salivary secretion_Homo sapiens_hsa049700.37317224
129Measles_Homo sapiens_hsa051620.37301483
130AMPK signaling pathway_Homo sapiens_hsa041520.36260787
131Gastric acid secretion_Homo sapiens_hsa049710.35762458
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33413011
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33290683
134Metabolic pathways_Homo sapiens_hsa011000.32549068
135Synaptic vesicle cycle_Homo sapiens_hsa047210.31960754
136African trypanosomiasis_Homo sapiens_hsa051430.30496365
137Herpes simplex infection_Homo sapiens_hsa051680.30267928
138Osteoclast differentiation_Homo sapiens_hsa043800.29654586
139TNF signaling pathway_Homo sapiens_hsa046680.29201788
140Basal cell carcinoma_Homo sapiens_hsa052170.28330288
141cAMP signaling pathway_Homo sapiens_hsa040240.28247626
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28143787
143Serotonergic synapse_Homo sapiens_hsa047260.27760900
144Circadian entrainment_Homo sapiens_hsa047130.27349369
145Endocytosis_Homo sapiens_hsa041440.26971992
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26809434
147Insulin resistance_Homo sapiens_hsa049310.26581016
148Alcoholism_Homo sapiens_hsa050340.24886198
149RNA degradation_Homo sapiens_hsa030180.24518705
150Phagosome_Homo sapiens_hsa041450.22790074
151Influenza A_Homo sapiens_hsa051640.22705837
152Rheumatoid arthritis_Homo sapiens_hsa053230.20074529
153Cocaine addiction_Homo sapiens_hsa050300.19280844
154VEGF signaling pathway_Homo sapiens_hsa043700.18979321
155Salmonella infection_Homo sapiens_hsa051320.18731121
156Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17469188
157Toxoplasmosis_Homo sapiens_hsa051450.15656424
158Central carbon metabolism in cancer_Homo sapiens_hsa052300.14290106

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