LRRC19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.04365432
2drug transport (GO:0015893)8.62736922
3organic cation transport (GO:0015695)7.80391842
4phosphate ion transport (GO:0006817)7.44903836
5drug catabolic process (GO:0042737)7.21725143
6regulation of guanylate cyclase activity (GO:0031282)7.20493295
7lysine metabolic process (GO:0006553)7.09662159
8lysine catabolic process (GO:0006554)7.09662159
9exogenous drug catabolic process (GO:0042738)6.48709804
10regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.40135945
11phosphate ion transmembrane transport (GO:0035435)6.27781068
12epoxygenase P450 pathway (GO:0019373)6.14229570
13positive regulation of guanylate cyclase activity (GO:0031284)6.00415531
14quaternary ammonium group transport (GO:0015697)5.96392381
15excretion (GO:0007588)5.74736654
16cellular glucuronidation (GO:0052695)5.66393907
17glucuronate metabolic process (GO:0019585)5.56882284
18uronic acid metabolic process (GO:0006063)5.56882284
19vitamin D metabolic process (GO:0042359)5.54682187
20glyoxylate metabolic process (GO:0046487)5.49386235
21renal absorption (GO:0070293)5.47880209
22nonribosomal peptide biosynthetic process (GO:0019184)5.47058475
23cysteine metabolic process (GO:0006534)5.46953955
24lipoprotein transport (GO:0042953)5.45406864
25fat-soluble vitamin biosynthetic process (GO:0042362)5.27309053
26toxin transport (GO:1901998)5.19714169
27homocysteine metabolic process (GO:0050667)5.16523375
28modified amino acid transport (GO:0072337)5.12249126
29phosphate ion homeostasis (GO:0055062)5.08869706
30trivalent inorganic anion homeostasis (GO:0072506)5.08869706
31regulation of protein glycosylation (GO:0060049)5.07283305
32response to mercury ion (GO:0046689)4.98730832
33metanephric nephron tubule development (GO:0072234)4.96468644
34metanephric tubule development (GO:0072170)4.96468644
35regulation of systemic arterial blood pressure by hormone (GO:0001990)4.89682343
36regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.89682343
37endocrine process (GO:0050886)4.89682343
38glutathione biosynthetic process (GO:0006750)4.85290069
39sulfate transport (GO:0008272)4.83596239
40short-chain fatty acid metabolic process (GO:0046459)4.80563492
41bile acid and bile salt transport (GO:0015721)4.78729248
42aspartate family amino acid catabolic process (GO:0009068)4.61149184
43oligosaccharide catabolic process (GO:0009313)4.60131828
44tricarboxylic acid metabolic process (GO:0072350)4.58918596
45metanephric nephron epithelium development (GO:0072243)4.50889371
46arginine metabolic process (GO:0006525)4.32978465
47branched-chain amino acid metabolic process (GO:0009081)4.32254453
48carnitine transport (GO:0015879)4.32234497
49amino-acid betaine transport (GO:0015838)4.32234497
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.30785654
51regulation of cGMP biosynthetic process (GO:0030826)4.30671961
52thrombin receptor signaling pathway (GO:0070493)4.27975754
53regulation of systemic arterial blood pressure (GO:0003073)4.26301309
54digestion (GO:0007586)4.23738336
55glycoside metabolic process (GO:0016137)4.23548150
56peptide biosynthetic process (GO:0043043)4.21339037
57metanephric epithelium development (GO:0072207)4.16243179
58regulation of triglyceride catabolic process (GO:0010896)4.15271040
59fructose metabolic process (GO:0006000)4.14441946
60polyol transport (GO:0015791)4.11192728
61indole-containing compound catabolic process (GO:0042436)4.07365538
62indolalkylamine catabolic process (GO:0046218)4.07365538
63tryptophan catabolic process (GO:0006569)4.07365538
64proline metabolic process (GO:0006560)4.05847494
65sulfur compound transport (GO:0072348)4.04835299
66renal system process involved in regulation of blood volume (GO:0001977)4.04585967
67aromatic amino acid family catabolic process (GO:0009074)4.03928744
68response to phenylpropanoid (GO:0080184)3.99926902
69nephron tubule development (GO:0072080)3.97732143
70peptide catabolic process (GO:0043171)3.97129965
71hormone catabolic process (GO:0042447)3.93104070
72L-fucose catabolic process (GO:0042355)3.91998174
73fucose catabolic process (GO:0019317)3.91998174
74L-fucose metabolic process (GO:0042354)3.91998174
75receptor guanylyl cyclase signaling pathway (GO:0007168)3.90563454
76L-phenylalanine catabolic process (GO:0006559)3.89797206
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.89797206
78cellular ketone body metabolic process (GO:0046950)3.84782310
79tryptophan metabolic process (GO:0006568)3.84582318
80vitamin biosynthetic process (GO:0009110)3.82375682
81fatty acid beta-oxidation (GO:0006635)3.81787436
82sulfation (GO:0051923)3.79914608
83L-phenylalanine metabolic process (GO:0006558)3.79880591
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.79880591
85peptide hormone processing (GO:0016486)3.79489225
86transcytosis (GO:0045056)3.75359407
87sulfate transmembrane transport (GO:1902358)3.73194961
88cellular modified amino acid catabolic process (GO:0042219)3.72420519
89valine metabolic process (GO:0006573)3.69642397
90negative regulation of cytosolic calcium ion concentration (GO:0051481)3.69203743
91amino-acid betaine metabolic process (GO:0006577)3.65955053
92regulation of cellular extravasation (GO:0002691)3.65231047
93heme transport (GO:0015886)3.61826665
94vitamin A metabolic process (GO:0006776)3.59551309
95regulation of cGMP metabolic process (GO:0030823)3.59384537
96serine family amino acid catabolic process (GO:0009071)3.57826245
97branched-chain amino acid catabolic process (GO:0009083)3.57666250
98serine family amino acid metabolic process (GO:0009069)3.57151738
99renal tubule development (GO:0061326)3.57145402
100NADH metabolic process (GO:0006734)3.57074438
101sodium ion transport (GO:0006814)3.55329760
102positive regulation of icosanoid secretion (GO:0032305)3.53524343
103cytidine metabolic process (GO:0046087)3.53359450
104cytidine catabolic process (GO:0006216)3.53359450
105cytidine deamination (GO:0009972)3.53359450
106alkaloid metabolic process (GO:0009820)3.52064411
107positive regulation of fatty acid transport (GO:2000193)3.51011423
108drug metabolic process (GO:0017144)3.49017194
109fatty acid oxidation (GO:0019395)3.48399466
110glutathione metabolic process (GO:0006749)3.48173502
111transepithelial transport (GO:0070633)3.47646530
112behavioral response to ethanol (GO:0048149)3.47337444
113glutathione derivative metabolic process (GO:1901685)3.46968476
114glutathione derivative biosynthetic process (GO:1901687)3.46968476
115fat-soluble vitamin metabolic process (GO:0006775)3.44677905
116intestinal absorption (GO:0050892)3.43614826
117vitamin transport (GO:0051180)3.43302584
118lipid oxidation (GO:0034440)3.42587958
119quinone biosynthetic process (GO:1901663)3.42325801
120positive regulation of cGMP biosynthetic process (GO:0030828)3.41189919
121sodium-independent organic anion transport (GO:0043252)3.41123822
122carnitine metabolic process (GO:0009437)3.40796767
123proline transport (GO:0015824)3.40387192
124nephron epithelium morphogenesis (GO:0072088)3.39986514
125nephron tubule morphogenesis (GO:0072078)3.39986514
126flavonoid metabolic process (GO:0009812)3.38950658
1272-oxoglutarate metabolic process (GO:0006103)3.38182355
128adhesion of symbiont to host cell (GO:0044650)3.36240191
129virion attachment to host cell (GO:0019062)3.36240191
130cellular response to vitamin D (GO:0071305)3.33829295
131positive regulation of glycoprotein biosynthetic process (GO:0010560)3.31427427
132auditory receptor cell differentiation (GO:0042491)3.29714591
133ketone body metabolic process (GO:1902224)3.29566514
134cobalamin metabolic process (GO:0009235)3.28912562
135cellular carbohydrate catabolic process (GO:0044275)3.26524954
136glycerol metabolic process (GO:0006071)3.26434370
137glutamate metabolic process (GO:0006536)3.25420072
138nephron epithelium development (GO:0072009)3.24555828
139alditol metabolic process (GO:0019400)3.22448196
140angiotensin maturation (GO:0002003)3.22295628
141bicarbonate transport (GO:0015701)3.21433187
142maintenance of gastrointestinal epithelium (GO:0030277)3.20934774
143acetyl-CoA metabolic process (GO:0006084)3.19855373
144kidney morphogenesis (GO:0060993)3.17402166
145indole-containing compound metabolic process (GO:0042430)3.16719803
146regulation of vitamin metabolic process (GO:0030656)3.15044696
147fatty acid catabolic process (GO:0009062)3.14676519
148digestive system process (GO:0022600)3.14263944
149neurotransmitter biosynthetic process (GO:0042136)3.13543278
150vitamin transmembrane transport (GO:0035461)3.11414646
151regulation of bile acid biosynthetic process (GO:0070857)3.11366715
152glycosylceramide metabolic process (GO:0006677)3.11317157
153pyrimidine ribonucleoside catabolic process (GO:0046133)3.08193311
154bile acid metabolic process (GO:0008206)3.07355294
155omega-hydroxylase P450 pathway (GO:0097267)3.06871214
156oligosaccharide biosynthetic process (GO:0009312)3.06445779
157glycine transport (GO:0015816)3.05660195
158diacylglycerol metabolic process (GO:0046339)3.05550607
159polyol catabolic process (GO:0046174)3.04589583
1603-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.03933733
161purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.03933733
162thyroid hormone metabolic process (GO:0042403)3.02289885
163positive regulation of respiratory burst (GO:0060267)2.98114625
164sodium ion homeostasis (GO:0055078)2.95843703
165UDP-N-acetylglucosamine metabolic process (GO:0006047)2.94672524
166arginine catabolic process (GO:0006527)2.93790996
167cGMP biosynthetic process (GO:0006182)2.92047610
168phosphatidylserine acyl-chain remodeling (GO:0036150)2.90205069
169opioid receptor signaling pathway (GO:0038003)2.89248462
170O-glycan processing (GO:0016266)2.89179115
171cellular response to ammonium ion (GO:0071242)2.88772541
172positive regulation of fatty acid beta-oxidation (GO:0032000)2.88688737
173calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.88605318
174fat-soluble vitamin catabolic process (GO:0042363)2.88069480
175vitamin catabolic process (GO:0009111)2.88069480
176fucosylation (GO:0036065)2.87540561
177coenzyme catabolic process (GO:0009109)2.87155949
178drug transmembrane transport (GO:0006855)10.1382253
179urate metabolic process (GO:0046415)10.0412934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human2.86481193
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.79617408
3VDR_22108803_ChIP-Seq_LS180_Human2.70452978
4GBX2_23144817_ChIP-Seq_PC3_Human2.68952260
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.64075750
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.53380089
7CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.50555460
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45934271
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.42585549
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36383300
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.26198483
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21136627
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.20282591
14ZNF274_21170338_ChIP-Seq_K562_Hela2.10711766
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.09561042
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.05398017
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.85356314
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.85109660
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.84805327
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73141381
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60687585
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59917702
23GATA4_25053715_ChIP-Seq_YYC3_Human1.57666905
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57114656
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54661287
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.50138692
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.46780107
28FUS_26573619_Chip-Seq_HEK293_Human1.46567151
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45506512
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43549694
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42789809
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41750284
33CBP_20019798_ChIP-Seq_JUKART_Human1.41750284
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41685168
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.41302839
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39021538
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38641348
38FOXA1_21572438_ChIP-Seq_LNCaP_Human1.38320925
39NANOG_19829295_ChIP-Seq_ESCs_Human1.38176363
40SOX2_19829295_ChIP-Seq_ESCs_Human1.38176363
41SMAD3_21741376_ChIP-Seq_HESCs_Human1.37557328
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.35717329
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.33355009
44SOX2_20726797_ChIP-Seq_SW620_Human1.31692826
45NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30888209
46TAF15_26573619_Chip-Seq_HEK293_Human1.30369181
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.30087572
48NANOG_20526341_ChIP-Seq_ESCs_Human1.28721267
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.28492615
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28180596
51TCF4_18268006_ChIP-ChIP_LS174T_Human1.28132519
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.28090637
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27287729
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27033074
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26587443
56IGF1R_20145208_ChIP-Seq_DFB_Human1.25593484
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25139737
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25129601
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25129601
60FOXA1_25552417_ChIP-Seq_VCAP_Human1.22954585
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22860296
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22832476
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22354328
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21808257
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21650494
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21234795
67P300_19829295_ChIP-Seq_ESCs_Human1.20942204
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20788625
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20079572
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.19978130
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19959726
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19702749
73STAT3_23295773_ChIP-Seq_U87_Human1.18683587
74HNF4A_19822575_ChIP-Seq_HepG2_Human1.17938861
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.17763788
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17763788
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17227259
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.16991729
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16734957
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16709097
81AR_21909140_ChIP-Seq_LNCAP_Human1.16622375
82AR_20517297_ChIP-Seq_VCAP_Human1.16472788
83AR_25329375_ChIP-Seq_VCAP_Human1.15930825
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15804928
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15475733
86TCF4_23295773_ChIP-Seq_U87_Human1.14179986
87SMAD4_21799915_ChIP-Seq_A2780_Human1.13771753
88PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12502966
89EGR1_19032775_ChIP-ChIP_M12_Human1.12409930
90CEBPB_22108803_ChIP-Seq_LS180_Human1.12066297
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.11834941
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.10882491
93ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10825278
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10585243
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09889110
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09796490
97SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08671894
98NCOR_22424771_ChIP-Seq_293T_Human1.08577591
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08406686
100CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07890184
101SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07653195
102AHR_22903824_ChIP-Seq_MCF-7_Human1.07471883
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07283411
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.07263041
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07257889
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07257889
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07031799
108ER_23166858_ChIP-Seq_MCF-7_Human1.06282579
109* CDX2_22108803_ChIP-Seq_LS180_Human1.06282543
110RXR_22108803_ChIP-Seq_LS180_Human1.05505603
111SMAD4_21741376_ChIP-Seq_HESCs_Human1.04735829
112DROSHA_22980978_ChIP-Seq_HELA_Human1.04517613
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04492257
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04131924
115EZH2_27304074_Chip-Seq_ESCs_Mouse1.04068137
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03512071
117SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02946152
118ETV1_20927104_ChIP-Seq_GIST48_Human1.02787940
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.02489178
120KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02118048
121EZH2_27294783_Chip-Seq_ESCs_Mouse1.01839649
122GATA3_21878914_ChIP-Seq_MCF-7_Human1.01642803
123PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01123689
124IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00439894
125ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99748458
126FOXA2_19822575_ChIP-Seq_HepG2_Human0.99516419
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99289581
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98507100
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98507100
130GATA1_22025678_ChIP-Seq_K562_Human0.98205368
131GATA6_25053715_ChIP-Seq_YYC3_Human0.97747017
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97713170
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97122158
134OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97077099
135TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94875026
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94182719
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94050004
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93680492
139POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93279292
140TP53_18474530_ChIP-ChIP_U2OS_Human0.93224380
141BCAT_22108803_ChIP-Seq_LS180_Human0.92553855
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91944760
143TCF4_22108803_ChIP-Seq_LS180_Human0.91825213
144TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91727430
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.91359650
146AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91263590
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89859375
148EZH2_27294783_Chip-Seq_NPCs_Mouse0.89763739
149EP300_21415370_ChIP-Seq_HL-1_Mouse0.89646124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.54124679
2MP0004043_abnormal_pH_regulation6.45203093
3MP0004019_abnormal_vitamin_homeostasis4.84069792
4MP0005332_abnormal_amino_acid4.46407281
5MP0002139_abnormal_hepatobiliary_system4.25710793
6MP0003195_calcinosis3.77913778
7MP0001765_abnormal_ion_homeostasis3.68944172
8MP0002138_abnormal_hepatobiliary_system3.57967682
9MP0009643_abnormal_urine_homeostasis3.51214614
10MP0003878_abnormal_ear_physiology3.24045780
11MP0005377_hearing/vestibular/ear_phenot3.24045780
12MP0005636_abnormal_mineral_homeostasis2.92424051
13MP0003252_abnormal_bile_duct2.86792959
14MP0008875_abnormal_xenobiotic_pharmacok2.82242468
15MP0002136_abnormal_kidney_physiology2.63977823
16MP0001756_abnormal_urination2.60550046
17MP0005085_abnormal_gallbladder_physiolo2.44757845
18MP0005365_abnormal_bile_salt2.32743122
19MP0001958_emphysema2.28878786
20MP0001501_abnormal_sleep_pattern2.20991825
21MP0000538_abnormal_urinary_bladder2.17419891
22MP0001666_abnormal_nutrient_absorption2.16297352
23MP0010155_abnormal_intestine_physiology2.04357537
24MP0002876_abnormal_thyroid_physiology2.02689214
25MP0004147_increased_porphyrin_level1.90462488
26MP0005084_abnormal_gallbladder_morpholo1.86548061
27MP0003868_abnormal_feces_composition1.82436081
28MP0004885_abnormal_endolymph1.71974599
29MP0004264_abnormal_extraembryonic_tissu1.70679225
30MP0009780_abnormal_chondrocyte_physiolo1.65529650
31MP0009379_abnormal_foot_pigmentation1.63000086
32MP0009840_abnormal_foam_cell1.55874639
33MP0003718_maternal_effect1.46851814
34MP0001873_stomach_inflammation1.32433254
35MP0000490_abnormal_crypts_of1.30712966
36MP0005584_abnormal_enzyme/coenzyme_acti1.25878932
37MP0003300_gastrointestinal_ulcer1.22081935
38MP0005451_abnormal_body_composition1.21543358
39MP0008961_abnormal_basal_metabolism1.19380396
40MP0003186_abnormal_redox_activity1.17911846
41MP0000230_abnormal_systemic_arterial1.16298819
42MP0003646_muscle_fatigue1.09080313
43MP0005645_abnormal_hypothalamus_physiol1.08320912
44MP0002928_abnormal_bile_duct1.07915527
45MP0010386_abnormal_urinary_bladder1.05171845
46MP0005058_abnormal_lysosome_morphology1.04731452
47MP0001764_abnormal_homeostasis1.04659857
48MP0001188_hyperpigmentation1.04267193
49MP0010234_abnormal_vibrissa_follicle1.02353535
50MP0005319_abnormal_enzyme/_coenzyme1.02185005
51MP0004782_abnormal_surfactant_physiolog1.01378888
52MP0001663_abnormal_digestive_system0.99313389
53MP0004270_analgesia0.98567233
54MP0005448_abnormal_energy_balance0.97771447
55MP0001664_abnormal_digestion0.96355291
56MP0002089_abnormal_postnatal_growth/wei0.95832730
57MP0003806_abnormal_nucleotide_metabolis0.93603047
58MP0008775_abnormal_heart_ventricle0.92414938
59MP0002896_abnormal_bone_mineralization0.91784069
60MP0005381_digestive/alimentary_phenotyp0.91079648
61MP0005166_decreased_susceptibility_to0.90570671
62MP0002135_abnormal_kidney_morphology0.90245359
63MP0001485_abnormal_pinna_reflex0.89900002
64MP0005551_abnormal_eye_electrophysiolog0.88600396
65MP0004742_abnormal_vestibular_system0.86753918
66MP0000462_abnormal_digestive_system0.85950005
67MP0003045_fibrosis0.85890870
68MP0005535_abnormal_body_temperature0.85704895
69MP0004858_abnormal_nervous_system0.84590574
70MP0006036_abnormal_mitochondrial_physio0.83847193
71MP0002971_abnormal_brown_adipose0.83233161
72MP0002168_other_aberrant_phenotype0.82956486
73MP0010352_gastrointestinal_tract_polyps0.81847195
74MP0003283_abnormal_digestive_organ0.81095180
75MP0000537_abnormal_urethra_morphology0.80733508
76MP0003183_abnormal_peptide_metabolism0.76222708
77MP0010329_abnormal_lipoprotein_level0.71913622
78MP0002118_abnormal_lipid_homeostasis0.71637316
79MP0002009_preneoplasia0.71287779
80MP0001963_abnormal_hearing_physiology0.69789971
81MP0003638_abnormal_response/metabolism_0.69525144
82MP0003866_abnormal_defecation0.67920770
83MP0009642_abnormal_blood_homeostasis0.66754081
84MP0002733_abnormal_thermal_nociception0.65559658
85MP0000427_abnormal_hair_cycle0.65495280
86MP0003315_abnormal_perineum_morphology0.64736339
87MP0001919_abnormal_reproductive_system0.64340683
88MP0000678_abnormal_parathyroid_gland0.63233512
89MP0003724_increased_susceptibility_to0.63025168
90MP0000026_abnormal_inner_ear0.62678788
91MP0005646_abnormal_pituitary_gland0.62645083
92MP0010678_abnormal_skin_adnexa0.62202887
93MP0004215_abnormal_myocardial_fiber0.61526754
94MP0001968_abnormal_touch/_nociception0.61390737
95MP0005670_abnormal_white_adipose0.61093021
96MP0005174_abnormal_tail_pigmentation0.60736081
97MP0001845_abnormal_inflammatory_respons0.60070301
98MP0002006_tumorigenesis0.58601524
99MP0005220_abnormal_exocrine_pancreas0.56720103
100MP0001661_extended_life_span0.56663719
101MP0003938_abnormal_ear_development0.55989886
102MP0003879_abnormal_hair_cell0.55605029
103MP0002166_altered_tumor_susceptibility0.55082019
104MP0009764_decreased_sensitivity_to0.54469214
105MP0005395_other_phenotype0.54091682
106MP0000681_abnormal_thyroid_gland0.53715779
107MP0005666_abnormal_adipose_tissue0.52755056
108MP0000470_abnormal_stomach_morphology0.51954228
109MP0003191_abnormal_cellular_cholesterol0.51930781
110MP0001177_atelectasis0.51754627
111MP0005367_renal/urinary_system_phenotyp0.51505485
112MP0000516_abnormal_urinary_system0.51505485
113MP0002796_impaired_skin_barrier0.51267780
114MP0000015_abnormal_ear_pigmentation0.50636661
115MP0004484_altered_response_of0.50405299
116MP0001986_abnormal_taste_sensitivity0.50357410
117MP0002098_abnormal_vibrissa_morphology0.50090439
118MP0005334_abnormal_fat_pad0.48675545
119MP0005310_abnormal_salivary_gland0.48523087
120MP0002115_abnormal_skeleton_extremities0.46956065
121MP0002272_abnormal_nervous_system0.46763166
122MP0005501_abnormal_skin_physiology0.45118753
123MP0002069_abnormal_eating/drinking_beha0.44801815
124MP0000566_synostosis0.43312205
125MP0000163_abnormal_cartilage_morphology0.42847584
126MP0003953_abnormal_hormone_level0.42717615
127MP0005408_hypopigmentation0.42607738
128MP0005167_abnormal_blood-brain_barrier0.41763639
129MP0008872_abnormal_physiological_respon0.41144578
130MP0005165_increased_susceptibility_to0.38904521
131MP0003941_abnormal_skin_development0.37851059
132MP0000609_abnormal_liver_physiology0.37664486
133MP0003795_abnormal_bone_structure0.35540047
134MP0003959_abnormal_lean_body0.35187378
135MP0000477_abnormal_intestine_morphology0.35079910
136MP0002078_abnormal_glucose_homeostasis0.34800346
137MP0002735_abnormal_chemical_nociception0.34656569
138MP0001270_distended_abdomen0.30399941
139MP0000534_abnormal_ureter_morphology0.30129452
140MP0000762_abnormal_tongue_morphology0.30088605
141MP0002998_abnormal_bone_remodeling0.29815585
142MP0002822_catalepsy0.29795561
143MP0008469_abnormal_protein_level0.29727541

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.94103127
2Metabolic alkalosis (HP:0200114)7.71121437
3Hyperactive renin-angiotensin system (HP:0000841)7.34862570
4Hypokalemic alkalosis (HP:0001949)7.10351915
5Hypomagnesemia (HP:0002917)7.05346998
6Abnormality of chloride homeostasis (HP:0011422)6.55802160
7Polyuria (HP:0000103)6.33833903
8Gout (HP:0001997)6.20583643
9Abnormal urine output (HP:0012590)6.05263676
10Abnormality of magnesium homeostasis (HP:0004921)6.00024573
11Abnormality of renal excretion (HP:0011036)5.82510159
12Proximal tubulopathy (HP:0000114)5.44601540
13Abnormality of glutamine family amino acid metabolism (HP:0010902)5.19760563
14Abnormality of renin-angiotensin system (HP:0000847)5.16864939
15Abnormal drinking behavior (HP:0030082)5.11818598
16Polydipsia (HP:0001959)5.11818598
17Hyperaldosteronism (HP:0000859)4.96393035
18Tetany (HP:0001281)4.92419584
19Alkalosis (HP:0001948)4.77816854
20Increased purine levels (HP:0004368)4.68792598
21Hyperuricemia (HP:0002149)4.68792598
22Hyperglycinuria (HP:0003108)4.51397789
23Renal salt wasting (HP:0000127)4.49571715
24Abnormality of purine metabolism (HP:0004352)4.32726418
25Chronic diarrhea (HP:0002028)4.08355890
26Hypercalciuria (HP:0002150)3.99647443
27Hypobetalipoproteinemia (HP:0003563)3.98803152
28Glycosuria (HP:0003076)3.91364264
29Abnormality of urine glucose concentration (HP:0011016)3.91364264
30Hypokalemia (HP:0002900)3.80794511
31Generalized aminoaciduria (HP:0002909)3.73177044
32Pigmentary retinal degeneration (HP:0001146)3.70808112
33Abnormality of vitamin metabolism (HP:0100508)3.66466039
34Abnormality of glycine metabolism (HP:0010895)3.59658899
35Abnormality of serine family amino acid metabolism (HP:0010894)3.59658899
36Fat malabsorption (HP:0002630)3.58801090
37Congenital sensorineural hearing impairment (HP:0008527)3.57784815
38Renal tubular acidosis (HP:0001947)3.45718665
39Abnormality of proline metabolism (HP:0010907)3.43330154
40Hydroxyprolinuria (HP:0003080)3.43330154
41Ketoacidosis (HP:0001993)3.36040355
42Thyroid-stimulating hormone excess (HP:0002925)3.34300588
43Abnormality of potassium homeostasis (HP:0011042)3.26747495
44Hyperphosphaturia (HP:0003109)3.26198432
45Acanthocytosis (HP:0001927)3.23559221
46Delayed epiphyseal ossification (HP:0002663)3.22761585
47Abnormal urine phosphate concentration (HP:0012599)3.18179150
48Abnormality of nucleobase metabolism (HP:0010932)3.17346819
49Widely patent fontanelles and sutures (HP:0004492)3.03460998
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.95614434
51Vascular calcification (HP:0004934)2.85513662
52Dehydration (HP:0001944)2.85226208
53Nephrolithiasis (HP:0000787)2.85029913
54Abdominal distention (HP:0003270)2.80521050
55Nephrocalcinosis (HP:0000121)2.78300077
56Hypophosphatemia (HP:0002148)2.76038227
57Ketosis (HP:0001946)2.73645829
58Enlarged kidneys (HP:0000105)2.67305267
59Malnutrition (HP:0004395)2.64272002
60Abnormal biliary tract morphology (HP:0012440)2.62920882
61Rickets (HP:0002748)2.61187319
62Posterior subcapsular cataract (HP:0007787)2.55510469
63Abnormality of fatty-acid metabolism (HP:0004359)2.53628056
64Confusion (HP:0001289)2.51665099
65Cardiovascular calcification (HP:0011915)2.51195419
66Nausea (HP:0002018)2.43404606
67Abnormality of renal resorption (HP:0011038)2.42307832
68Renal cortical cysts (HP:0000803)2.40580178
69Renal tubular dysfunction (HP:0000124)2.33402694
70Metabolic acidosis (HP:0001942)2.33101663
71Potter facies (HP:0002009)2.33092215
72Facial shape deformation (HP:0011334)2.33092215
73Hyponatremia (HP:0002902)2.32549389
74Hyperglycinemia (HP:0002154)2.31176578
75Abnormality of sodium homeostasis (HP:0010931)2.29127862
76Vacuolated lymphocytes (HP:0001922)2.25490795
77Decreased circulating renin level (HP:0003351)2.23540867
78Hypothermia (HP:0002045)2.17000522
79Adrenal overactivity (HP:0002717)2.13089708
80Abnormal tarsal ossification (HP:0008369)2.12509732
81Vomiting (HP:0002013)2.12141232
82Stomach cancer (HP:0012126)2.09851999
83Hypoalbuminemia (HP:0003073)2.06931206
84Abnormal albumin level (HP:0012116)2.06931206
85Abnormality of sulfur amino acid metabolism (HP:0004339)2.06266452
86Abnormality of the vitamin B12 metabolism (HP:0004341)2.06212574
87Megaloblastic anemia (HP:0001889)2.05574747
88Hyperammonemia (HP:0001987)2.04741146
89Ileus (HP:0002595)2.04548934
90Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04325739
91Dicarboxylic aciduria (HP:0003215)2.04325739
92Tubular atrophy (HP:0000092)2.04300325
93Delayed CNS myelination (HP:0002188)2.04061003
94Thin bony cortex (HP:0002753)2.03755505
95Metaphyseal cupping (HP:0003021)2.03356463
96Abnormal enzyme/coenzyme activity (HP:0012379)2.02448813
97Xanthomatosis (HP:0000991)1.99577565
98Abnormality of alkaline phosphatase activity (HP:0004379)1.98505073
99Abnormality of monocarboxylic acid metabolism (HP:0010996)1.98230818
100Metaphyseal irregularity (HP:0003025)1.98112288
101Bilateral sensorineural hearing impairment (HP:0008619)1.94331450
102Late onset (HP:0003584)1.93707414
103Syncope (HP:0001279)1.93561875
104Villous atrophy (HP:0011473)1.93555838
105Abnormality of small intestinal villus morphology (HP:0011472)1.93555838
106Intestinal atresia (HP:0011100)1.92536610
107Tubulointerstitial fibrosis (HP:0005576)1.92284749
108Abnormality of vitamin B metabolism (HP:0004340)1.90631652
109Steatorrhea (HP:0002570)1.89890574
110Lethargy (HP:0001254)1.88920597
111Congenital stationary night blindness (HP:0007642)1.87480800
112Right ventricular cardiomyopathy (HP:0011663)1.87200127
113Methylmalonic aciduria (HP:0012120)1.86665056
114Abolished electroretinogram (ERG) (HP:0000550)1.86629617
115Metaphyseal dysplasia (HP:0100255)1.85794746
116Chorioretinal atrophy (HP:0000533)1.83697988
117Large for gestational age (HP:0001520)1.82114594
118Epidermoid cyst (HP:0200040)1.80223197
119Autoimmune thrombocytopenia (HP:0001973)1.79869161
120Intrahepatic cholestasis (HP:0001406)1.78802254
121Hypophosphatemic rickets (HP:0004912)1.78758564
122Abnormality of the costochondral junction (HP:0000919)1.77062128
123Pancreatic cysts (HP:0001737)1.75127333
124Hypoproteinemia (HP:0003075)1.74952135
125Palpitations (HP:0001962)1.74753388
126Hypolipoproteinemia (HP:0010981)1.74506347
127Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74180713
128Enlarged epiphyses (HP:0010580)1.72152300
129Goiter (HP:0000853)1.71468615
130Abnormality of carpal bone ossification (HP:0006257)1.71164964
131Flat acetabular roof (HP:0003180)1.70666053
132Abnormality of the renal cortex (HP:0011035)1.70522993
133Abnormality of Sharpey fibers (HP:0100685)1.70458820
134Chondrocalcinosis (HP:0000934)1.70378457
135Pancreatitis (HP:0001733)1.70275756
136Cerebral palsy (HP:0100021)1.68530607
137Hyperventilation (HP:0002883)1.68059613
138Bicornuate uterus (HP:0000813)1.67882295
139Hyperkalemia (HP:0002153)1.66699241
140Hypotension (HP:0002615)1.66548346
141Conjugated hyperbilirubinemia (HP:0002908)1.61694769
142Elevated alkaline phosphatase (HP:0003155)1.61656854
143Wide cranial sutures (HP:0010537)1.61380502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.15777911
2WNK37.85173378
3OXSR17.58228939
4STK394.72939726
5ADRBK24.37042348
6STK38L2.46365401
7FRK2.39237509
8BMPR1B2.26102965
9STK242.20261957
10MST42.15184243
11MST1R2.09448158
12ERN11.99820325
13TAOK31.84237294
14WNK11.80803717
15SGK4941.69577223
16SGK2231.69577223
17BCKDK1.60195044
18EPHA21.45153860
19MAP4K21.44704283
20MAPKAPK31.41660521
21INSRR1.31007963
22NME11.30055712
23PDK41.27441242
24PDK31.27441242
25PDK21.27034683
26NEK11.21838319
27ADRBK11.12253368
28LMTK21.09735077
29SGK21.06980501
30MAP3K121.04278712
31SGK30.99268221
32EPHA30.93657241
33BLK0.89130606
34GRK60.85771567
35MAP3K100.84850514
36STK380.83998590
37EIF2AK30.79471120
38DAPK20.75288518
39TXK0.74893099
40NLK0.71075745
41CASK0.69859577
42FER0.69012442
43MAPKAPK50.68743478
44PINK10.68483068
45TLK10.67441354
46MAPK130.67267252
47ERBB30.66446775
48MAP3K70.65843774
49PTK60.65796683
50GSK3A0.65785445
51MYLK0.63829068
52EPHB20.62414820
53MAP3K20.61785448
54PRKCI0.61723171
55SGK10.58788346
56MET0.58713157
57MAP2K60.58439640
58PRKAA20.57758288
59CAMK2A0.57105992
60PRKG20.56634095
61EPHA40.56393143
62MATK0.55687811
63TGFBR10.55511825
64BRSK20.53694673
65PRKAA10.53465493
66EPHB10.52965659
67AKT30.51574820
68TEC0.51080585
69PRKCG0.50513171
70GRK50.49908752
71PAK30.49238629
72NUAK10.47961706
73CAMKK20.47609903
74MAP2K20.47066763
75PIK3CG0.46706779
76CAMK2D0.46425588
77MAP3K40.44829617
78PTK20.43971842
79MAP3K140.42426807
80BCR0.39465287
81PDPK10.37798873
82ERBB40.37788991
83PBK0.37434288
84TRIM280.37301629
85MUSK0.37249914
86TIE10.36770185
87PIM10.36458196
88ITK0.35515365
89LRRK20.35123552
90TNIK0.34988481
91PRKCZ0.34115422
92NEK60.31463877
93PRKCE0.29637159
94PRKCB0.29608194
95MAP2K70.28917442
96CSNK1G10.28479774
97STK110.27679019
98MAPK110.27571328
99GRK10.27444395
100MAP3K30.26829046
101PLK20.26018995
102IGF1R0.25282014
103PRKCA0.25271895
104MKNK20.24342958
105ACVR1B0.24336097
106PRKACA0.24299357
107PRKCD0.23893487
108CSNK1G30.23791164
109PRKACG0.22904523
110YES10.22332203
111DYRK1B0.22306966
112IRAK30.22257075
113CSNK1G20.22235053
114FGFR20.21913255
115PRKD20.21709228
116CAMK2B0.21063014
117PKN10.20958639
118ROCK10.20836719
119PRKG10.19357168
120PAK40.18605792
121TRPM70.18259656
122IKBKB0.17841734
123MAPK150.17749421
124SYK0.17591964
125TGFBR20.17220583
126CSNK1A10.17177384
127ABL10.16530241
128MAP2K10.16511453
129IRAK10.16329787
130PIK3CA0.14388462
131ERBB20.14005362
132DYRK1A0.13989226
133PTK2B0.13556307
134RIPK10.13187941
135PDK10.13156048
136FGFR40.13079277
137PRKCQ0.10576659
138ABL20.10544799
139ZAK0.09856146
140TTK0.09459491
141KSR10.09176475
142STK30.08773457
143MARK10.08542247
144BMPR20.08390395
145ROCK20.08150040
146CAMK2G0.07689995
147MAP2K40.07484730

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.63801569
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.59073804
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.42273426
4Caffeine metabolism_Homo sapiens_hsa002323.14684729
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.02993857
6Vitamin digestion and absorption_Homo sapiens_hsa049772.89830480
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.89722200
8Propanoate metabolism_Homo sapiens_hsa006402.78077936
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.76872534
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.66798887
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62484864
12Mineral absorption_Homo sapiens_hsa049782.46010666
13Linoleic acid metabolism_Homo sapiens_hsa005912.38098921
14Sulfur metabolism_Homo sapiens_hsa009202.33474032
15Peroxisome_Homo sapiens_hsa041462.29728363
16Collecting duct acid secretion_Homo sapiens_hsa049662.16288342
17Tryptophan metabolism_Homo sapiens_hsa003802.13820454
18Pyruvate metabolism_Homo sapiens_hsa006202.12412376
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.11277920
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07606864
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04836999
22Fatty acid degradation_Homo sapiens_hsa000712.00012526
23Bile secretion_Homo sapiens_hsa049761.93440873
24Protein digestion and absorption_Homo sapiens_hsa049741.80464502
25beta-Alanine metabolism_Homo sapiens_hsa004101.79024054
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.78603433
27Renin-angiotensin system_Homo sapiens_hsa046141.71573978
28Glutathione metabolism_Homo sapiens_hsa004801.69204925
29Arginine and proline metabolism_Homo sapiens_hsa003301.52596755
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.49939235
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49194806
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.47654784
33Starch and sucrose metabolism_Homo sapiens_hsa005001.45967218
34Ether lipid metabolism_Homo sapiens_hsa005651.43328199
35Fatty acid metabolism_Homo sapiens_hsa012121.41786691
36Histidine metabolism_Homo sapiens_hsa003401.39529785
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31153624
38Carbon metabolism_Homo sapiens_hsa012001.28879335
39Lysine degradation_Homo sapiens_hsa003101.24717950
40PPAR signaling pathway_Homo sapiens_hsa033201.21425917
41Other glycan degradation_Homo sapiens_hsa005111.20516503
42Folate biosynthesis_Homo sapiens_hsa007901.14061646
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12772952
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.11780346
45Fructose and mannose metabolism_Homo sapiens_hsa000511.07714833
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07624121
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.06649659
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06159776
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04627161
50Glycerolipid metabolism_Homo sapiens_hsa005611.02329431
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93685780
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91937478
53Oxidative phosphorylation_Homo sapiens_hsa001900.91673154
54Fat digestion and absorption_Homo sapiens_hsa049750.90815856
55Arginine biosynthesis_Homo sapiens_hsa002200.90189570
56Phenylalanine metabolism_Homo sapiens_hsa003600.82775570
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82304760
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73912782
59Selenocompound metabolism_Homo sapiens_hsa004500.72414707
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70239646
61Asthma_Homo sapiens_hsa053100.69015926
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.68292925
63Thyroid hormone synthesis_Homo sapiens_hsa049180.67841236
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.64418561
65Gastric acid secretion_Homo sapiens_hsa049710.62003105
66Fatty acid elongation_Homo sapiens_hsa000620.61146316
67Arachidonic acid metabolism_Homo sapiens_hsa005900.59762863
68Sphingolipid metabolism_Homo sapiens_hsa006000.59267082
69Metabolic pathways_Homo sapiens_hsa011000.59235806
70Vibrio cholerae infection_Homo sapiens_hsa051100.58283538
71Galactose metabolism_Homo sapiens_hsa000520.57810382
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.53103058
73Biosynthesis of amino acids_Homo sapiens_hsa012300.53058517
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52999658
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50998708
76Chemical carcinogenesis_Homo sapiens_hsa052040.50937037
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49537532
78Parkinsons disease_Homo sapiens_hsa050120.47345276
79Steroid biosynthesis_Homo sapiens_hsa001000.45325185
80Phototransduction_Homo sapiens_hsa047440.44858927
81Nitrogen metabolism_Homo sapiens_hsa009100.43356744
82Renin secretion_Homo sapiens_hsa049240.43014675
83ABC transporters_Homo sapiens_hsa020100.42934201
84Retinol metabolism_Homo sapiens_hsa008300.42418244
85Pentose phosphate pathway_Homo sapiens_hsa000300.38654269
86Graft-versus-host disease_Homo sapiens_hsa053320.38356802
87Fatty acid biosynthesis_Homo sapiens_hsa000610.38229942
88Ovarian steroidogenesis_Homo sapiens_hsa049130.36979720
89Dorso-ventral axis formation_Homo sapiens_hsa043200.36235084
90Allograft rejection_Homo sapiens_hsa053300.35461861
91Serotonergic synapse_Homo sapiens_hsa047260.34617302
92Autoimmune thyroid disease_Homo sapiens_hsa053200.34196371
93Type I diabetes mellitus_Homo sapiens_hsa049400.31455658
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.31350535
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.30932089
96Insulin secretion_Homo sapiens_hsa049110.30591768
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30546669
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30306088
99Choline metabolism in cancer_Homo sapiens_hsa052310.30112069
100Alzheimers disease_Homo sapiens_hsa050100.26188327
101Synaptic vesicle cycle_Homo sapiens_hsa047210.25709783
102Lysosome_Homo sapiens_hsa041420.25631133
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25339208
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24362523
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23106259
106Cardiac muscle contraction_Homo sapiens_hsa042600.21070563
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.19431207
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17787869
109Taste transduction_Homo sapiens_hsa047420.17148521
110Tyrosine metabolism_Homo sapiens_hsa003500.13264617
111Sulfur relay system_Homo sapiens_hsa041220.12579702
112Pancreatic secretion_Homo sapiens_hsa049720.11914429
113Olfactory transduction_Homo sapiens_hsa047400.10478676
114Huntingtons disease_Homo sapiens_hsa050160.09894928
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.08747003
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08566537
117Inositol phosphate metabolism_Homo sapiens_hsa005620.07741700
118Rheumatoid arthritis_Homo sapiens_hsa053230.06780861
119Tight junction_Homo sapiens_hsa045300.05824068
120Insulin resistance_Homo sapiens_hsa049310.04998697
121Salivary secretion_Homo sapiens_hsa049700.04502985
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.03805331
123Amphetamine addiction_Homo sapiens_hsa050310.02811554
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.02085234
125Staphylococcus aureus infection_Homo sapiens_hsa051500.00896524
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.00331130
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0199525
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0191730
129Hepatitis C_Homo sapiens_hsa05160-0.0175700
130Glucagon signaling pathway_Homo sapiens_hsa04922-0.0097966
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860-0.0045750

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