LRRC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.00212159
2cardiac myofibril assembly (GO:0055003)8.20756337
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.66121109
4myofibril assembly (GO:0030239)7.65414604
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.50229928
6actin-myosin filament sliding (GO:0033275)7.37500466
7muscle filament sliding (GO:0030049)7.37500466
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)7.16174736
9regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.96474045
10tricarboxylic acid cycle (GO:0006099)6.82159298
11negative regulation of potassium ion transmembrane transport (GO:1901380)6.80912928
12regulation of skeletal muscle contraction (GO:0014819)6.69586051
13regulation of relaxation of muscle (GO:1901077)6.67746195
14cardiac muscle contraction (GO:0060048)6.67678398
15sarcoplasmic reticulum calcium ion transport (GO:0070296)6.40405970
16regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.28973410
17regulation of actin filament-based movement (GO:1903115)6.24313971
18cardiac muscle cell development (GO:0055013)6.14948220
19actin-mediated cell contraction (GO:0070252)6.12425714
20regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)6.12034757
21regulation of cell communication by electrical coupling (GO:0010649)5.90055626
22plasma membrane repair (GO:0001778)5.77925647
23cardiac cell development (GO:0055006)5.75334402
24regulation of acyl-CoA biosynthetic process (GO:0050812)5.70410829
25bundle of His cell to Purkinje myocyte communication (GO:0086069)5.62921356
26regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.61042505
27actomyosin structure organization (GO:0031032)5.57655026
28striated muscle contraction (GO:0006941)5.56883324
29cardiac muscle hypertrophy (GO:0003300)5.50663465
30ventricular cardiac muscle cell action potential (GO:0086005)5.45853858
31regulation of sarcomere organization (GO:0060297)5.37613877
32response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.37006941
33cardiac muscle tissue morphogenesis (GO:0055008)5.34277677
34carnitine shuttle (GO:0006853)5.33179724
35heart process (GO:0003015)5.32927446
36heart contraction (GO:0060047)5.32927446
37striated muscle hypertrophy (GO:0014897)5.25166447
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.20907600
39regulation of cofactor metabolic process (GO:0051193)5.19282418
40regulation of coenzyme metabolic process (GO:0051196)5.19282418
41regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.09908660
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.06300241
43adult heart development (GO:0007512)5.06298882
44regulation of striated muscle contraction (GO:0006942)4.92262771
45oxidative phosphorylation (GO:0006119)4.90965824
46ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.85552291
47respiratory electron transport chain (GO:0022904)4.81876837
48muscle tissue morphogenesis (GO:0060415)4.80874795
49energy coupled proton transport, down electrochemical gradient (GO:0015985)4.67449180
50ATP synthesis coupled proton transport (GO:0015986)4.67449180
51electron transport chain (GO:0022900)4.66763464
52regulation of membrane repolarization (GO:0060306)4.64233976
53muscle hypertrophy (GO:0014896)4.64170147
54fatty acid transmembrane transport (GO:1902001)4.55636483
55heart trabecula formation (GO:0060347)4.53024521
56skeletal muscle contraction (GO:0003009)4.49777639
57actin filament-based movement (GO:0030048)4.44084066
58skeletal muscle fiber development (GO:0048741)4.43584133
59myotube cell development (GO:0014904)4.35312079
60cell communication involved in cardiac conduction (GO:0086065)4.33482138
61regulation of cardiac muscle cell contraction (GO:0086004)4.32266314
62muscle fiber development (GO:0048747)4.31345434
63creatine metabolic process (GO:0006600)4.25336547
64regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.21919672
65regulation of the force of heart contraction (GO:0002026)4.21765661
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.17239256
67regulation of sulfur metabolic process (GO:0042762)4.14611632
68regulation of cardiac muscle contraction (GO:0055117)4.11148147
69membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.09866583
70cardiac muscle cell action potential (GO:0086001)4.04273372
71cardiac muscle cell action potential involved in contraction (GO:0086002)3.98674720
72glycogen catabolic process (GO:0005980)3.95346189
73positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.94481803
74NADH metabolic process (GO:0006734)3.89760564
75relaxation of cardiac muscle (GO:0055119)3.85364860
76carnitine transmembrane transport (GO:1902603)3.83570006
77regulation of sequestering of triglyceride (GO:0010889)3.83406377
78ubiquinone biosynthetic process (GO:0006744)3.82570146
79quinone biosynthetic process (GO:1901663)3.82570146
80muscle contraction (GO:0006936)3.81605260
81skeletal muscle adaptation (GO:0043501)3.79510983
82negative regulation of calcium ion transmembrane transport (GO:1903170)3.78554706
83negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.78554706
84response to inactivity (GO:0014854)3.78264301
85cardiac muscle adaptation (GO:0014887)3.78199367
86cardiac muscle hypertrophy in response to stress (GO:0014898)3.78199367
87muscle hypertrophy in response to stress (GO:0003299)3.78199367
88regulation of heart rate (GO:0002027)3.78040816
892-oxoglutarate metabolic process (GO:0006103)3.71021100
90regulation of ATPase activity (GO:0043462)3.68689995
91regulation of ATP catabolic process (GO:1903289)3.68689995
92striated muscle cell development (GO:0055002)3.67017965
93glucan catabolic process (GO:0009251)3.66032295
94negative regulation of potassium ion transport (GO:0043267)3.65849212
95skeletal muscle tissue development (GO:0007519)3.64378568
96negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.62044083
97glycogen biosynthetic process (GO:0005978)3.61705634
98glucan biosynthetic process (GO:0009250)3.61705634
99striated muscle adaptation (GO:0014888)3.61131127
100cell communication by electrical coupling (GO:0010644)3.56957276
101positive regulation of cation channel activity (GO:2001259)3.56184979
102response to caffeine (GO:0031000)3.55981638
103muscle system process (GO:0003012)3.55613797
104response to muscle activity (GO:0014850)3.50758332
105positive regulation of heart rate (GO:0010460)3.50616171
106regulation of calcium ion transmembrane transporter activity (GO:1901019)3.47870105
107regulation of calcium ion transmembrane transport (GO:1903169)3.47870105
108regulation of heart contraction (GO:0008016)3.47559537
109cardiac conduction (GO:0061337)3.47495107
110detection of calcium ion (GO:0005513)3.44182197
111pyrimidine ribonucleoside catabolic process (GO:0046133)3.43569289
112carnitine transport (GO:0015879)3.42391583
113amino-acid betaine transport (GO:0015838)3.42391583
114negative regulation of protein localization to cell surface (GO:2000009)3.41655300
115cellular polysaccharide catabolic process (GO:0044247)3.40779362
116striated muscle atrophy (GO:0014891)3.39397600
117aspartate family amino acid catabolic process (GO:0009068)3.28546416
118skeletal muscle tissue regeneration (GO:0043403)3.20889957
119relaxation of muscle (GO:0090075)3.20775891
120muscle cell cellular homeostasis (GO:0046716)3.20539475
121regulation of muscle system process (GO:0090257)3.19427836
122regulation of muscle contraction (GO:0006937)3.18940951
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14082943
124muscle structure development (GO:0061061)3.07857971
125polysaccharide catabolic process (GO:0000272)3.07098050
126muscle atrophy (GO:0014889)3.06929611
127muscle adaptation (GO:0043500)3.04839137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.89617504
2* ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.67689115
3* EP300_21415370_ChIP-Seq_HL-1_Mouse5.19152816
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.87806636
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.61458264
6* TBX20_22080862_ChIP-Seq_HEART_Mouse4.47285373
7* TBX20_22328084_ChIP-Seq_HEART_Mouse4.47285373
8MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.83229074
9* GATA4_21415370_ChIP-Seq_HL-1_Mouse3.28665247
10ZNF263_19887448_ChIP-Seq_K562_Human3.20414108
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.97309817
12GBX2_23144817_ChIP-Seq_PC3_Human2.91000161
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.81431363
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55093019
15NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.46544786
16IGF1R_20145208_ChIP-Seq_DFB_Human2.45567898
17BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.44418079
18* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.43799643
19* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.42984451
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.30586422
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27293360
22* STAT3_1855785_ChIP-Seq_MESCs_Mouse2.24911677
23* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.23613900
24EZH2_22144423_ChIP-Seq_EOC_Human2.20071990
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.15989216
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13857818
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09978069
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.06785949
29POU3F2_20337985_ChIP-ChIP_501MEL_Human2.00273714
30ZNF274_21170338_ChIP-Seq_K562_Hela1.88991609
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.80115882
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75966288
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67046411
34* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66632630
35ER_23166858_ChIP-Seq_MCF-7_Human1.61896948
36* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.61522917
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.59118783
38FUS_26573619_Chip-Seq_HEK293_Human1.53374997
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.52381638
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51122599
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.48898610
42SMAD4_21799915_ChIP-Seq_A2780_Human1.48427981
43P300_19829295_ChIP-Seq_ESCs_Human1.47612102
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46464904
45TAF15_26573619_Chip-Seq_HEK293_Human1.43291352
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.42573458
47CRX_20693478_ChIP-Seq_RETINA_Mouse1.39097000
48VDR_22108803_ChIP-Seq_LS180_Human1.37805054
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.36995649
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.36765517
51* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35811979
52CBP_20019798_ChIP-Seq_JUKART_Human1.35054664
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35054664
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35048537
55* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34806297
56SOX2_19829295_ChIP-Seq_ESCs_Human1.34416781
57NANOG_19829295_ChIP-Seq_ESCs_Human1.34416781
58TCF4_23295773_ChIP-Seq_U87_Human1.34209922
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.33773493
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33329228
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32392991
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32343005
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30840673
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.30388366
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30221353
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30196655
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27466141
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.26786435
69SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.26730207
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26361605
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.26164441
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25509294
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.24985270
74BCAT_22108803_ChIP-Seq_LS180_Human1.24777810
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23163392
76STAT3_23295773_ChIP-Seq_U87_Human1.22496184
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22446664
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21220187
79GATA1_22025678_ChIP-Seq_K562_Human1.20599431
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19761272
81OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19548432
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17603396
83AR_21572438_ChIP-Seq_LNCaP_Human1.16301945
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15464952
85* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15271096
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.13928610
87AR_25329375_ChIP-Seq_VCAP_Human1.13797792
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.13414385
89HTT_18923047_ChIP-ChIP_STHdh_Human1.12357328
90AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10200292
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09421965
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09251818
93CTCF_27219007_Chip-Seq_Bcells_Human1.06183300
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05600149
95ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05580734
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04486610
97CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03350533
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.02993483
99NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02845385
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02845385
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02775518
102PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02490170
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02470113
104P53_22387025_ChIP-Seq_ESCs_Mouse1.01808054
105* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01149231
106FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01148616
107CIITA_25753668_ChIP-Seq_RAJI_Human0.99834911
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99152780
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96424525
110* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96208690
111E2F1_18555785_Chip-Seq_ESCs_Mouse0.96090725
112EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96005903
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95177010
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94753623
115* CDX2_22108803_ChIP-Seq_LS180_Human0.94427239
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93865046
117* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.93861254
118EZH2_27304074_Chip-Seq_ESCs_Mouse0.93339854
119P68_20966046_ChIP-Seq_HELA_Human0.93270506
120* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93232921
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92742512
122OCT4_20526341_ChIP-Seq_ESCs_Human0.92644435
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92494505
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91154244
125* DROSHA_22980978_ChIP-Seq_HELA_Human0.90730103
126SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89951559
127NFYB_21822215_ChIP-Seq_K562_Human0.89672938
128NANOG_18555785_Chip-Seq_ESCs_Mouse0.89635041
129TP63_22573176_ChIP-Seq_HFKS_Human0.88853788
130TBL1_22424771_ChIP-Seq_293T_Human0.88602178
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88434628
132FOXH1_21741376_ChIP-Seq_ESCs_Human0.88180969
133CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87860976
134* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87351603
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87247699
136TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86413158
137RBPJ_21746931_ChIP-Seq_IB4_Human0.86263834
138JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86217260
139* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85002334
140HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83642826
141* SPI1_20517297_ChIP-Seq_HL60_Human0.81362376
142PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79806350
143DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78839646
144PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78280874
145E2F1_20622854_ChIP-Seq_HELA_Human0.78035155
146GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77264476
147GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.77124199
148MYC_19829295_ChIP-Seq_ESCs_Human0.75944965
149* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.74701788
150TDRD3_21172665_ChIP-Seq_MCF-7_Human0.74143835
151CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.74052418
152TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73412301
153PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72875323
154OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71868209
155PHF8_20622853_ChIP-Seq_HELA_Human0.71561226
156* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.70930717
157* SMAD3_21741376_ChIP-Seq_HESCs_Human0.69660523
158ATF3_27146783_Chip-Seq_COLON_Human0.69058504
159* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.68634060
160CBX2_22325352_ChIP-Seq_293T-Rex_Human0.68606963
161ETS1_20019798_ChIP-Seq_JURKAT_Human0.67050985
162HOXB7_26014856_ChIP-Seq_BT474_Human0.66063987
163CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.65825071
164BCL6_27268052_Chip-Seq_Bcells_Human0.65800437
165* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65508688
166TBX3_20139965_ChIP-Seq_ESCs_Mouse0.65450028
167CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.65274714
168* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.65250816
169ETV1_20927104_ChIP-Seq_GIST48_Human0.64806470
170TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.64758743
171ESR2_21235772_ChIP-Seq_MCF-7_Human0.64305066
172HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.64073184

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.46565700
2MP0003646_muscle_fatigue6.37244117
3MP0004084_abnormal_cardiac_muscle5.32465415
4MP0000751_myopathy5.25319883
5MP0004215_abnormal_myocardial_fiber4.73670166
6MP0000749_muscle_degeneration4.27775124
7MP0004036_abnormal_muscle_relaxation4.10318298
8MP0005330_cardiomyopathy3.88474101
9MP0004087_abnormal_muscle_fiber3.15443219
10MP0004145_abnormal_muscle_electrophysio3.07547275
11MP0002972_abnormal_cardiac_muscle2.99802812
12MP0000750_abnormal_muscle_regeneration2.94835081
13MP0003137_abnormal_impulse_conducting2.88166779
14MP0008775_abnormal_heart_ventricle2.84186302
15MP0002106_abnormal_muscle_physiology2.82938623
16MP0005620_abnormal_muscle_contractility2.76893533
17MP0004484_altered_response_of2.74349375
18MP0004130_abnormal_muscle_cell2.73719505
19MP0002269_muscular_atrophy2.56865055
20MP0001544_abnormal_cardiovascular_syste2.56433199
21MP0005385_cardiovascular_system_phenoty2.56433199
22MP0010630_abnormal_cardiac_muscle2.50133541
23MP0005369_muscle_phenotype2.30288733
24MP0000747_muscle_weakness2.21982171
25MP0000759_abnormal_skeletal_muscle2.21114285
26MP0006138_congestive_heart_failure2.13865796
27MP0003828_pulmonary_edema2.12153831
28MP0006036_abnormal_mitochondrial_physio2.10114693
29MP0003221_abnormal_cardiomyocyte_apopto2.03548661
30MP0004085_abnormal_heartbeat1.97368905
31MP0002127_abnormal_cardiovascular_syste1.83543827
32MP0002332_abnormal_exercise_endurance1.77777503
33MP0004233_abnormal_muscle_weight1.77417027
34MP0003950_abnormal_plasma_membrane1.73962524
35MP0004510_myositis1.66286585
36MP0005670_abnormal_white_adipose1.55569885
37MP0005666_abnormal_adipose_tissue1.51233567
38MP0003567_abnormal_fetal_cardiomyocyte1.35005144
39MP0006035_abnormal_mitochondrial_morpho1.32601277
40MP0000343_altered_response_to1.23889711
41MP0004270_analgesia1.15523118
42MP0001661_extended_life_span1.14499097
43MP0005165_increased_susceptibility_to1.12496022
44MP0000266_abnormal_heart_morphology1.12240390
45MP0005266_abnormal_metabolism1.09251034
46MP0000372_irregular_coat_pigmentation1.04930129
47MP0004185_abnormal_adipocyte_glucose1.02651030
48MP0002108_abnormal_muscle_morphology1.01888895
49MP0002234_abnormal_pharynx_morphology0.96822732
50MP0003806_abnormal_nucleotide_metabolis0.96203706
51MP0009780_abnormal_chondrocyte_physiolo0.93997007
52MP0002638_abnormal_pupillary_reflex0.92695551
53MP0005375_adipose_tissue_phenotype0.89608446
54MP0001984_abnormal_olfaction0.79393232
55MP0004142_abnormal_muscle_tone0.79198897
56MP0004043_abnormal_pH_regulation0.77252084
57MP0002876_abnormal_thyroid_physiology0.75904267
58MP0003279_aneurysm0.72559741
59MP0000230_abnormal_systemic_arterial0.67456237
60MP0010368_abnormal_lymphatic_system0.65213134
61MP0002128_abnormal_blood_circulation0.63704224
62MP0005167_abnormal_blood-brain_barrier0.61679303
63MP0000733_abnormal_muscle_development0.60562731
64MP0006276_abnormal_autonomic_nervous0.58613325
65MP0005332_abnormal_amino_acid0.58488768
66MP0002272_abnormal_nervous_system0.56122617
67MP0005623_abnormal_meninges_morphology0.55687297
68MP0004147_increased_porphyrin_level0.54790434
69MP0001485_abnormal_pinna_reflex0.53520581
70MP0003566_abnormal_cell_adhesion0.53357193
71MP0009745_abnormal_behavioral_response0.52742396
72MP0003941_abnormal_skin_development0.50423159
73MP0004134_abnormal_chest_morphology0.49845538
74MP0005551_abnormal_eye_electrophysiolog0.48618161
75MP0002734_abnormal_mechanical_nocicepti0.48289982
76MP0002971_abnormal_brown_adipose0.48169500
77MP0008872_abnormal_physiological_respon0.47097656
78MP0005253_abnormal_eye_physiology0.46362324
79MP0003984_embryonic_growth_retardation0.45214453
80MP0001501_abnormal_sleep_pattern0.44064742
81MP0001299_abnormal_eye_distance/0.43929774
82MP0002078_abnormal_glucose_homeostasis0.43827980
83MP0005645_abnormal_hypothalamus_physiol0.43660652
84MP0008569_lethality_at_weaning0.43605087
85MP0006072_abnormal_retinal_apoptosis0.43246432
86MP0002088_abnormal_embryonic_growth/wei0.43163203
87MP0002067_abnormal_sensory_capabilities0.42890484
88MP0009046_muscle_twitch0.42306476
89MP0001879_abnormal_lymphatic_vessel0.40636363
90MP0005423_abnormal_somatic_nervous0.40541686
91MP0003879_abnormal_hair_cell0.40052846
92MP0001486_abnormal_startle_reflex0.40028097
93MP0000767_abnormal_smooth_muscle0.39701104
94MP0001986_abnormal_taste_sensitivity0.39004692
95MP0004133_heterotaxia0.38073566
96MP0005451_abnormal_body_composition0.37958662
97MP0005319_abnormal_enzyme/_coenzyme0.37457570
98MP0002925_abnormal_cardiovascular_devel0.35908354
99MP0002102_abnormal_ear_morphology0.34318545
100MP0005187_abnormal_penis_morphology0.33903968
101MP0002909_abnormal_adrenal_gland0.33734534
102MP0000003_abnormal_adipose_tissue0.32567898
103MP0005380_embryogenesis_phenotype0.32153893
104MP0001672_abnormal_embryogenesis/_devel0.32153893
105MP0001853_heart_inflammation0.31878879
106MP0002066_abnormal_motor_capabilities/c0.31382692
107MP0002064_seizures0.29704927
108MP0005646_abnormal_pituitary_gland0.27914385
109MP0005334_abnormal_fat_pad0.27174288
110MP0005376_homeostasis/metabolism_phenot0.26555521
111MP0003136_yellow_coat_color0.26207888
112MP0001784_abnormal_fluid_regulation0.25947662
113MP0005535_abnormal_body_temperature0.24887086
114MP0005386_behavior/neurological_phenoty0.24702662
115MP0004924_abnormal_behavior0.24702662
116MP0001727_abnormal_embryo_implantation0.24384035
117MP0001614_abnormal_blood_vessel0.23998318
118MP0002877_abnormal_melanocyte_morpholog0.22679943
119MP0003948_abnormal_gas_homeostasis0.22347865
120MP0009115_abnormal_fat_cell0.21482817
121MP0001529_abnormal_vocalization0.21371767
122MP0003195_calcinosis0.21175137
123MP0002822_catalepsy0.20790284
124MP0000358_abnormal_cell_content/0.19618163
125MP0000013_abnormal_adipose_tissue0.18620857
126MP0003045_fibrosis0.17705466
127MP0000579_abnormal_nail_morphology0.17129110
128MP0005452_abnormal_adipose_tissue0.17039244
129MP0003186_abnormal_redox_activity0.14990090
130MP0000762_abnormal_tongue_morphology0.14771033
131MP0005595_abnormal_vascular_smooth0.11622022
132MP0001697_abnormal_embryo_size0.10198267
133MP0005275_abnormal_skin_tensile0.10072841

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.35312929
2Ventricular tachycardia (HP:0004756)6.79486720
3Calf muscle hypertrophy (HP:0008981)6.67041659
4Exercise-induced myalgia (HP:0003738)6.30173512
5Muscle hypertrophy of the lower extremities (HP:0008968)6.29747930
6Exercise-induced muscle cramps (HP:0003710)6.17801291
7Atrial fibrillation (HP:0005110)5.89731004
8Muscle fiber splitting (HP:0003555)5.73793636
9Primary atrial arrhythmia (HP:0001692)5.50684261
10Supraventricular tachycardia (HP:0004755)5.34450318
11Abnormality of the calf musculature (HP:0001430)5.29144842
12Myoglobinuria (HP:0002913)5.24305357
13Supraventricular arrhythmia (HP:0005115)5.20508769
14Hyporeflexia of lower limbs (HP:0002600)5.00330143
15Lipoatrophy (HP:0100578)4.93885445
16Distal arthrogryposis (HP:0005684)4.76472531
17Right ventricular cardiomyopathy (HP:0011663)4.70526095
18Myopathic facies (HP:0002058)4.58549490
19Syncope (HP:0001279)4.50485916
20Bundle branch block (HP:0011710)4.47648463
21Subaortic stenosis (HP:0001682)4.41199176
22Abnormality of the left ventricular outflow tract (HP:0011103)4.41199176
23Dilated cardiomyopathy (HP:0001644)4.24614942
24Palpitations (HP:0001962)4.24010424
25EMG: myopathic abnormalities (HP:0003458)4.22698463
26Rhabdomyolysis (HP:0003201)4.18976402
27Increased connective tissue (HP:0009025)3.91055249
28Prolonged QT interval (HP:0001657)3.82455168
29Round ear (HP:0100830)3.77288023
30Heart block (HP:0012722)3.73914877
31Muscle fiber inclusion bodies (HP:0100299)3.72142163
32Difficulty running (HP:0009046)3.70791780
33Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.63845290
34Centrally nucleated skeletal muscle fibers (HP:0003687)3.63296825
35Ventricular arrhythmia (HP:0004308)3.62480624
36Acute necrotizing encephalopathy (HP:0006965)3.60653286
37Asymmetric septal hypertrophy (HP:0001670)3.56085639
38Abnormal mitochondria in muscle tissue (HP:0008316)3.56045754
39Abnormal atrioventricular conduction (HP:0005150)3.51479021
40Frequent falls (HP:0002359)3.44242869
41Ulnar deviation of the wrist (HP:0003049)3.38971883
42Myotonia (HP:0002486)3.37747149
43Hepatic necrosis (HP:0002605)3.36907762
44Atrioventricular block (HP:0001678)3.35743892
45Distal lower limb muscle weakness (HP:0009053)3.32210823
46Absent phalangeal crease (HP:0006109)3.12779256
47Areflexia of lower limbs (HP:0002522)3.11870158
48Acute encephalopathy (HP:0006846)3.04626709
49Progressive macrocephaly (HP:0004481)2.98762426
50Left ventricular hypertrophy (HP:0001712)2.98002099
51Hepatocellular necrosis (HP:0001404)2.97756875
52Nemaline bodies (HP:0003798)2.95723914
53Ventricular fibrillation (HP:0001663)2.95112169
54Abnormality of alanine metabolism (HP:0010916)2.92598506
55Hyperalaninemia (HP:0003348)2.92598506
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.92598506
57Mitochondrial inheritance (HP:0001427)2.89471286
58Difficulty climbing stairs (HP:0003551)2.86196446
59Calcaneovalgus deformity (HP:0001848)2.83326288
60Abnormal EKG (HP:0003115)2.80404217
61Increased CSF lactate (HP:0002490)2.80129513
62Muscle stiffness (HP:0003552)2.75009436
63Cerebral edema (HP:0002181)2.68168768
64Testicular atrophy (HP:0000029)2.67439848
65Exercise intolerance (HP:0003546)2.64701362
66Abnormal finger flexion creases (HP:0006143)2.61411264
67Type 1 muscle fiber predominance (HP:0003803)2.60976373
68Rimmed vacuoles (HP:0003805)2.60773956
69Ketoacidosis (HP:0001993)2.57992702
70Deformed tarsal bones (HP:0008119)2.56344820
71Hypoglycemic coma (HP:0001325)2.55321419
72Increased muscle lipid content (HP:0009058)2.54482408
73Palmoplantar keratoderma (HP:0000982)2.51852213
74Dicarboxylic aciduria (HP:0003215)2.50205052
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50205052
76Neck muscle weakness (HP:0000467)2.46775651
77Lactic acidosis (HP:0003128)2.45396873
78Malignant hyperthermia (HP:0002047)2.44207225
79Increased variability in muscle fiber diameter (HP:0003557)2.36805797
80Abnormality of skeletal muscle fiber size (HP:0012084)2.34897879
81Increased intramyocellular lipid droplets (HP:0012240)2.34417012
82Respiratory failure (HP:0002878)2.32063961
83Mildly elevated creatine phosphokinase (HP:0008180)2.31980941
84Limb-girdle muscle atrophy (HP:0003797)2.30169510
85Hyperkalemia (HP:0002153)2.28473442
86Abnormality of fatty-acid metabolism (HP:0004359)2.22860306
87Distal lower limb amyotrophy (HP:0008944)2.18419214
88Scapular winging (HP:0003691)2.12085018
89Hypoplastic ischia (HP:0003175)2.11701798
90Muscular dystrophy (HP:0003560)2.09859388
91Bulbar palsy (HP:0001283)2.07950268
92Weak cry (HP:0001612)2.07184187
93Proximal amyotrophy (HP:0007126)2.06959595
94Slender build (HP:0001533)2.06136182
95Fetal akinesia sequence (HP:0001989)2.04059728
96Central scotoma (HP:0000603)2.00701784
97Fatigable weakness (HP:0003473)2.00084406
98Abnormality of the neuromuscular junction (HP:0003398)2.00084406
99Progressive muscle weakness (HP:0003323)1.98647093
100Lipid accumulation in hepatocytes (HP:0006561)1.96005653
101Facial diplegia (HP:0001349)1.95769493
102EMG: neuropathic changes (HP:0003445)1.95601858
103Gowers sign (HP:0003391)1.94084113
104Hip contracture (HP:0003273)1.91505662
105Ragged-red muscle fibers (HP:0003200)1.91220214
106Decreased activity of mitochondrial respiratory chain (HP:0008972)1.90590800
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.90590800
108Large for gestational age (HP:0001520)1.89910417
109Esophageal neoplasm (HP:0100751)1.88442583
110Neoplasm of head and neck (HP:0012288)1.88442583
111Hyperinsulinemic hypoglycemia (HP:0000825)1.87795464
112Abnormality of the shoulder girdle musculature (HP:0001435)1.87581482
113Increased serum lactate (HP:0002151)1.87075277
114Generalized muscle weakness (HP:0003324)1.86419085
115Waddling gait (HP:0002515)1.85334891
116Foot dorsiflexor weakness (HP:0009027)1.85324886
117Conjunctival hamartoma (HP:0100780)1.84666917
118Abnormality of the foot musculature (HP:0001436)1.84387647
119Optic disc pallor (HP:0000543)1.82359448
120Abnormality of the ischium (HP:0003174)1.80720366
121Increased serum pyruvate (HP:0003542)1.80186397
122Abnormality of glycolysis (HP:0004366)1.80186397
123Congestive heart failure (HP:0001635)1.79739912
124Toxemia of pregnancy (HP:0100603)1.79392432
125Respiratory insufficiency due to muscle weakness (HP:0002747)1.75419454
126Type 2 muscle fiber atrophy (HP:0003554)1.65777783
127Spinal rigidity (HP:0003306)1.61566325
128Nonprogressive disorder (HP:0003680)1.57231498
129Steppage gait (HP:0003376)1.54726380
130Oligomenorrhea (HP:0000876)1.53566948
131Long clavicles (HP:0000890)1.45122803
132Hyperglycinuria (HP:0003108)1.44882445

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.38058932
2OBSCN5.32577918
3PHKG24.48342067
4PHKG14.48342067
5PDK43.93870374
6PDK33.93870374
7LMTK23.23877405
8MYLK3.12593693
9PINK12.85020056
10PDK22.68276469
11NEK12.68237766
12DMPK2.63953337
13BCKDK2.50673229
14MUSK2.47089954
15GRK72.20850814
16ZAK2.15579964
17PKN22.12508697
18PIK3CA2.07213236
19FRK2.00776358
20TIE11.78922638
21STK241.72064732
22MARK11.59046166
23CAMK2D1.24034935
24STK38L1.22168137
25BMPR1B1.21475883
26TRIB31.16518286
27STK41.15061878
28INSRR1.05880126
29ERBB31.04381734
30PRKD11.03600409
31NME11.03126320
32PAK31.02874270
33MAPK121.00877406
34LIMK11.00292826
35MAP3K70.99893710
36ADRBK20.95899913
37PRKAA10.94148377
38FLT30.89760426
39MAP2K30.86152637
40MAP2K40.85558790
41MAP4K20.85031732
42PRKAA20.83814882
43MAPK130.82896742
44CAMK40.82638748
45CDC42BPA0.81251828
46TRPM70.80663680
47PKN10.80252501
48MAPKAPK30.80121103
49NME20.79954591
50ACVR1B0.79719925
51WNK30.77888624
52MAP3K50.77154645
53ROCK10.74721032
54DAPK20.72476590
55ILK0.69115414
56NEK90.62845477
57PIK3CG0.61994674
58CAMK2A0.58191598
59STK380.58072697
60TNIK0.57114155
61RPS6KC10.55727049
62RPS6KL10.55727049
63CCNB10.54729824
64AKT20.52806995
65OXSR10.52544605
66MAP2K10.52166292
67CAMK2B0.51125873
68PRKACB0.50665081
69MAP3K30.49965643
70CAMK2G0.45611320
71PRKACA0.45165409
72WNK40.44850315
73TAOK30.44705762
74RPS6KA60.44467248
75ROCK20.42896882
76IRAK30.41897024
77NUAK10.41824003
78MAP3K40.41671072
79MAPK40.40268847
80NLK0.39763189
81CAMK10.39672936
82DAPK30.38815562
83TGFBR20.38362989
84WNK10.36952940
85PRKACG0.34925683
86KDR0.34793515
87PRKCE0.33550996
88TTK0.32128272
89TAOK20.30073690
90PTK2B0.29926212
91RPS6KA10.29920671
92STK110.29296696
93MAP2K60.29237727
94PNCK0.27382211
95AKT30.26591102
96MAPK70.26017913
97PDGFRA0.25687066
98DYRK1B0.25390360
99SGK2230.20488699
100SGK4940.20488699
101SGK30.20145764
102TGFBR10.20140939
103SGK10.19760345
104CASK0.19662867
105STK390.19601460
106PRKG10.19427464
107ICK0.18138747
108PLK20.17467945
109MOS0.17054203
110SGK20.16172133
111RPS6KB10.14975370
112MARK30.14568186
113PRKCA0.14332785
114PAK60.14240379
115PRKCQ0.13800876
116LATS20.13546313
117MKNK20.13341861
118TLK10.13162298
119ADRBK10.13102143
120MAPK110.12378358
121LATS10.12219518
122RPS6KA30.12095175
123PDK10.11801362
124RIPK10.11703618
125PDPK10.09327992
126EPHA30.07570701
127CDK40.07332329
128CSNK1D0.06971753
129MTOR0.06224329
130SRPK10.04704989
131GRK10.04464537
132RPS6KB20.03022113
133AURKB0.02970418
134MAP3K60.01336925
135PRKDC0.01030145
136AKT10.00824943
137MAPK80.00455208
138JAK1-0.0140021
139MAPKAPK2-0.0060944

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.09237518
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.44051418
3Cardiac muscle contraction_Homo sapiens_hsa042604.39729857
4Parkinsons disease_Homo sapiens_hsa050123.78650667
5Oxidative phosphorylation_Homo sapiens_hsa001903.76546846
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.62506145
7Dilated cardiomyopathy_Homo sapiens_hsa054143.58423420
8Propanoate metabolism_Homo sapiens_hsa006403.44889285
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.89077337
10Alzheimers disease_Homo sapiens_hsa050102.76646638
11Fatty acid degradation_Homo sapiens_hsa000712.72961872
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.64445318
13Carbon metabolism_Homo sapiens_hsa012002.57883531
14Huntingtons disease_Homo sapiens_hsa050162.57081625
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.53116791
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43035769
17Fatty acid metabolism_Homo sapiens_hsa012121.99911732
18Pyruvate metabolism_Homo sapiens_hsa006201.71779702
19Viral myocarditis_Homo sapiens_hsa054161.58757079
20Nitrogen metabolism_Homo sapiens_hsa009101.56163620
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37209787
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37193526
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21198751
24Fatty acid elongation_Homo sapiens_hsa000621.19440242
25Butanoate metabolism_Homo sapiens_hsa006501.17406343
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16738637
27Biosynthesis of amino acids_Homo sapiens_hsa012301.12486676
28Starch and sucrose metabolism_Homo sapiens_hsa005001.07015512
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06342477
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91545156
31Glucagon signaling pathway_Homo sapiens_hsa049220.90145283
32Insulin resistance_Homo sapiens_hsa049310.88286097
33Arginine and proline metabolism_Homo sapiens_hsa003300.88013988
34Insulin signaling pathway_Homo sapiens_hsa049100.87648331
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86323342
36cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82752279
37Adipocytokine signaling pathway_Homo sapiens_hsa049200.80891380
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79631082
39Calcium signaling pathway_Homo sapiens_hsa040200.78803583
40beta-Alanine metabolism_Homo sapiens_hsa004100.76815362
41Galactose metabolism_Homo sapiens_hsa000520.76558767
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75733923
43PPAR signaling pathway_Homo sapiens_hsa033200.71846828
44Olfactory transduction_Homo sapiens_hsa047400.70455235
45Salivary secretion_Homo sapiens_hsa049700.70445281
46HIF-1 signaling pathway_Homo sapiens_hsa040660.67353632
47Lysine degradation_Homo sapiens_hsa003100.65521783
48Fructose and mannose metabolism_Homo sapiens_hsa000510.64226204
49AMPK signaling pathway_Homo sapiens_hsa041520.60450861
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59203130
51ABC transporters_Homo sapiens_hsa020100.58455861
52Circadian rhythm_Homo sapiens_hsa047100.57310669
53Histidine metabolism_Homo sapiens_hsa003400.55787618
54Tryptophan metabolism_Homo sapiens_hsa003800.54597635
55Oxytocin signaling pathway_Homo sapiens_hsa049210.54262789
56GABAergic synapse_Homo sapiens_hsa047270.52482985
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50690214
58Morphine addiction_Homo sapiens_hsa050320.50289751
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50146991
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49041421
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.44435997
62Peroxisome_Homo sapiens_hsa041460.43874521
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43397491
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43375856
65Metabolic pathways_Homo sapiens_hsa011000.42886612
66Amphetamine addiction_Homo sapiens_hsa050310.42718385
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41755699
68Pancreatic secretion_Homo sapiens_hsa049720.41211926
69Type II diabetes mellitus_Homo sapiens_hsa049300.40503399
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.39870530
71Fatty acid biosynthesis_Homo sapiens_hsa000610.39661142
72Tight junction_Homo sapiens_hsa045300.39412017
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38601248
74Cholinergic synapse_Homo sapiens_hsa047250.38296246
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38166439
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.36889984
77Focal adhesion_Homo sapiens_hsa045100.35825074
78Sulfur metabolism_Homo sapiens_hsa009200.35636674
79Serotonergic synapse_Homo sapiens_hsa047260.34964113
80Phenylalanine metabolism_Homo sapiens_hsa003600.34863838
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34725249
82Arginine biosynthesis_Homo sapiens_hsa002200.34331971
83RNA polymerase_Homo sapiens_hsa030200.33024538
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32905040
85Purine metabolism_Homo sapiens_hsa002300.32885346
86Phototransduction_Homo sapiens_hsa047440.32473761
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32129654
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30959176
89Dopaminergic synapse_Homo sapiens_hsa047280.30350388
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.29651650
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28238357
92Glutamatergic synapse_Homo sapiens_hsa047240.28119401
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.27158178
94Caffeine metabolism_Homo sapiens_hsa002320.26899559
95cAMP signaling pathway_Homo sapiens_hsa040240.25548988
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25472050
97Long-term depression_Homo sapiens_hsa047300.25234609
98GnRH signaling pathway_Homo sapiens_hsa049120.24884451
99Selenocompound metabolism_Homo sapiens_hsa004500.24737551
100Proteasome_Homo sapiens_hsa030500.24603136
101Adherens junction_Homo sapiens_hsa045200.23940082
102RNA degradation_Homo sapiens_hsa030180.18372069
103Arachidonic acid metabolism_Homo sapiens_hsa005900.15505808
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.13709108
105Insulin secretion_Homo sapiens_hsa049110.13246070
106Renin secretion_Homo sapiens_hsa049240.13080666
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11418906
108FoxO signaling pathway_Homo sapiens_hsa040680.10725331
109Linoleic acid metabolism_Homo sapiens_hsa005910.09535792
110ECM-receptor interaction_Homo sapiens_hsa045120.09535190
111Gastric acid secretion_Homo sapiens_hsa049710.09150519
112Regulation of autophagy_Homo sapiens_hsa041400.08316540
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.08042146
114Ribosome_Homo sapiens_hsa030100.07729192
115Tyrosine metabolism_Homo sapiens_hsa003500.05761827
116Mismatch repair_Homo sapiens_hsa034300.05118958
117Taste transduction_Homo sapiens_hsa047420.04929857
118Homologous recombination_Homo sapiens_hsa034400.03263482
119Ovarian steroidogenesis_Homo sapiens_hsa049130.03132741
120mTOR signaling pathway_Homo sapiens_hsa041500.01004612
121Pentose phosphate pathway_Homo sapiens_hsa000300.00308947
122PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0832057
123Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0774169
124Amoebiasis_Homo sapiens_hsa05146-0.0697579
125MAPK signaling pathway_Homo sapiens_hsa04010-0.0579870
126Renal cell carcinoma_Homo sapiens_hsa05211-0.0577923
127Ubiquitin mediated proteolysis_Homo sapiens_hsa04120-0.0538699
128Fanconi anemia pathway_Homo sapiens_hsa03460-0.0234537
129Notch signaling pathway_Homo sapiens_hsa04330-0.0218156
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0193751
131Circadian entrainment_Homo sapiens_hsa04713-0.0167681
132Pyrimidine metabolism_Homo sapiens_hsa00240-0.0118376

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