LRRC24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of synapse structural plasticity (GO:0051823)8.50207205
2negative regulation of cell aging (GO:0090344)7.47435820
3GDP-mannose metabolic process (GO:0019673)6.88708661
4regulation of skeletal muscle contraction (GO:0014819)6.75441540
5cellular response to ATP (GO:0071318)6.52767061
6DNA strand renaturation (GO:0000733)6.03683203
7peptidyl-glutamic acid carboxylation (GO:0017187)6.02820493
8protein carboxylation (GO:0018214)6.02820493
9proline biosynthetic process (GO:0006561)5.68366422
10behavioral response to nicotine (GO:0035095)5.67705844
11adenosine receptor signaling pathway (GO:0001973)5.65387986
12mitotic cell cycle arrest (GO:0071850)5.60872781
13proline metabolic process (GO:0006560)4.99014077
14L-phenylalanine metabolic process (GO:0006558)4.98549916
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.98549916
16regulation of cytokine production involved in inflammatory response (GO:1900015)4.92042268
17detection of light stimulus involved in sensory perception (GO:0050962)4.87171751
18detection of light stimulus involved in visual perception (GO:0050908)4.87171751
19lens fiber cell differentiation (GO:0070306)4.83050170
20sulfur amino acid catabolic process (GO:0000098)4.74524321
21phosphatidylglycerol biosynthetic process (GO:0006655)4.65961859
22meiotic chromosome segregation (GO:0045132)4.62389194
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.57746936
24L-phenylalanine catabolic process (GO:0006559)4.57746936
25transcription from mitochondrial promoter (GO:0006390)4.44750327
26transepithelial transport (GO:0070633)4.43245997
27negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.42489057
28glyoxylate metabolic process (GO:0046487)4.28206659
29purinergic nucleotide receptor signaling pathway (GO:0035590)4.26205037
30cell migration in hindbrain (GO:0021535)4.23541287
31lysine metabolic process (GO:0006553)4.20510606
32lysine catabolic process (GO:0006554)4.20510606
33protein insertion into membrane (GO:0051205)4.18108714
34estrogen biosynthetic process (GO:0006703)4.11578089
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.10051425
36positive regulation of heat generation (GO:0031652)4.07793638
37mitochondrion distribution (GO:0048311)4.07641778
38carnitine shuttle (GO:0006853)4.07504536
39G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.06283464
40sensory perception of taste (GO:0050909)4.04107434
41negative regulation of fatty acid biosynthetic process (GO:0045717)4.02256387
42neuromuscular synaptic transmission (GO:0007274)4.02189232
43urinary tract smooth muscle contraction (GO:0014848)4.00185783
44fatty acid beta-oxidation (GO:0006635)4.00039116
45fatty acid transmembrane transport (GO:1902001)3.96054351
46rRNA methylation (GO:0031167)3.95810652
472-oxoglutarate metabolic process (GO:0006103)3.91525654
48acetyl-CoA metabolic process (GO:0006084)3.89687004
49regulation of phospholipid biosynthetic process (GO:0071071)3.88783433
50glutamine family amino acid biosynthetic process (GO:0009084)3.79694280
51aromatic amino acid family catabolic process (GO:0009074)3.75527748
52oxidative demethylation (GO:0070989)3.75424468
53cellular ketone body metabolic process (GO:0046950)3.72608388
54semaphorin-plexin signaling pathway (GO:0071526)3.71002207
55kynurenine metabolic process (GO:0070189)3.70169147
56rRNA modification (GO:0000154)3.65562334
57granulocyte differentiation (GO:0030851)3.64654402
58alpha-linolenic acid metabolic process (GO:0036109)3.61344334
59adenine nucleotide transport (GO:0051503)3.60599724
60fatty acid catabolic process (GO:0009062)3.60117763
61triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.59442660
62biotin metabolic process (GO:0006768)3.59286193
63aspartate family amino acid catabolic process (GO:0009068)3.57397266
64triglyceride homeostasis (GO:0070328)3.56837717
65acylglycerol homeostasis (GO:0055090)3.56837717
66short-chain fatty acid metabolic process (GO:0046459)3.55823321
67fatty acid oxidation (GO:0019395)3.54829722
68regulation of protein kinase A signaling (GO:0010738)3.53633835
69positive regulation of protein kinase C signaling (GO:0090037)3.53619740
70oxaloacetate metabolic process (GO:0006107)3.51319552
71lipid oxidation (GO:0034440)3.46452830
72regulation of cholesterol homeostasis (GO:2000188)3.44351469
73tricarboxylic acid cycle (GO:0006099)3.42234521
74peptidyl-glutamic acid modification (GO:0018200)3.41459600
75bile acid biosynthetic process (GO:0006699)3.41435489
76base-excision repair, AP site formation (GO:0006285)3.40418401
77monocarboxylic acid catabolic process (GO:0072329)3.40230161
78fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.36525707
79response to ATP (GO:0033198)3.36271937
80serine family amino acid catabolic process (GO:0009071)3.34974964
81positive regulation of synapse maturation (GO:0090129)3.34882292
82succinate metabolic process (GO:0006105)3.32231393
83alkaloid metabolic process (GO:0009820)3.31207714
84dicarboxylic acid biosynthetic process (GO:0043650)3.29559697
85NADH metabolic process (GO:0006734)3.29516739
86cysteine metabolic process (GO:0006534)3.29200550
87UV protection (GO:0009650)3.26323894
88cellular amino acid catabolic process (GO:0009063)3.26266304
89alpha-amino acid catabolic process (GO:1901606)3.26238141
90protein retention in ER lumen (GO:0006621)3.24641664
91glutamate metabolic process (GO:0006536)3.24618899
92cellular anion homeostasis (GO:0030002)3.22923840
93purine ribonucleotide transport (GO:0015868)3.22920680
94negative regulation of fatty acid metabolic process (GO:0045922)3.21708881
95synaptic vesicle maturation (GO:0016188)3.21142334
96valine metabolic process (GO:0006573)3.20783531
97regulation of feeding behavior (GO:0060259)3.18151568
98postsynaptic membrane organization (GO:0001941)3.18024448
99type B pancreatic cell proliferation (GO:0044342)3.17884286
100cilium or flagellum-dependent cell motility (GO:0001539)3.17484285
101purinergic receptor signaling pathway (GO:0035587)3.17160251
102amino-acid betaine metabolic process (GO:0006577)3.16751002
103neuromuscular process controlling posture (GO:0050884)3.16724890
104tricarboxylic acid metabolic process (GO:0072350)3.16715831
105regulation of cell aging (GO:0090342)3.16135258
106regulation of heat generation (GO:0031650)3.15281520
107ketone body metabolic process (GO:1902224)3.14889712
108synaptic vesicle docking involved in exocytosis (GO:0016081)3.14808188
109synaptic vesicle exocytosis (GO:0016079)3.14610051
110bile acid metabolic process (GO:0008206)3.13667632
111indole-containing compound catabolic process (GO:0042436)3.12549978
112indolalkylamine catabolic process (GO:0046218)3.12549978
113tryptophan catabolic process (GO:0006569)3.12549978
114glycogen catabolic process (GO:0005980)3.12045156
115organic acid catabolic process (GO:0016054)3.11016448
116carboxylic acid catabolic process (GO:0046395)3.11016448
117branched-chain amino acid metabolic process (GO:0009081)3.10665748
118positive regulation of fatty acid beta-oxidation (GO:0032000)3.09824184
119dicarboxylic acid catabolic process (GO:0043649)3.08728626
120cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.08470864
121peristalsis (GO:0030432)3.07408472
122regulation of triglyceride catabolic process (GO:0010896)3.06965141
123branched-chain amino acid catabolic process (GO:0009083)3.06367722
124regulation of protein homooligomerization (GO:0032462)3.06180233
125activation of adenylate cyclase activity (GO:0007190)3.05515575
126very-low-density lipoprotein particle assembly (GO:0034379)3.05421694
127coenzyme catabolic process (GO:0009109)3.04011445
128carnitine transmembrane transport (GO:1902603)3.03905615
129phosphate ion homeostasis (GO:0055062)3.03015485
130trivalent inorganic anion homeostasis (GO:0072506)3.03015485
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.01509998
132carnitine transport (GO:0015879)2.98337180
133amino-acid betaine transport (GO:0015838)2.98337180
134synaptic transmission, cholinergic (GO:0007271)2.96696125
135cytolysis (GO:0019835)2.95120395
136positive regulation of protein homooligomerization (GO:0032464)2.94243517
137sphingomyelin metabolic process (GO:0006684)2.94101243
138pyrimidine nucleobase catabolic process (GO:0006208)2.93133028
139DNA deamination (GO:0045006)2.93002892
140glucan catabolic process (GO:0009251)2.91758216
141positive regulation of TOR signaling (GO:0032008)2.91417189
142high-density lipoprotein particle remodeling (GO:0034375)2.91337564
143heme transport (GO:0015886)2.91314364
144regulation of fatty acid oxidation (GO:0046320)2.91277173
145cellular modified amino acid catabolic process (GO:0042219)2.91228379
146aromatic amino acid family metabolic process (GO:0009072)2.89211775
147oxidative phosphorylation (GO:0006119)2.88628095
148melanin biosynthetic process (GO:0042438)2.88413379
149urea cycle (GO:0000050)2.87399784
150urea metabolic process (GO:0019627)2.87399784
151fatty acid homeostasis (GO:0055089)2.86246916
152regulation of fatty acid beta-oxidation (GO:0031998)2.84633105
153tryptophan metabolic process (GO:0006568)2.82866045
154positive regulation of fatty acid oxidation (GO:0046321)2.80561365
155nucleoside transmembrane transport (GO:1901642)2.80164681
156negative regulation of interleukin-8 production (GO:0032717)2.80055093
157iron coordination entity transport (GO:1901678)2.77859296
158sialylation (GO:0097503)2.77079102
159startle response (GO:0001964)2.76997937
160nitrogen cycle metabolic process (GO:0071941)2.76196423
161protein import into peroxisome matrix (GO:0016558)2.76193307
162cardiolipin metabolic process (GO:0032048)2.75998118
163positive regulation of axonogenesis (GO:0050772)2.75903581
164carnitine metabolic process (GO:0009437)2.75302428
165cholesterol efflux (GO:0033344)2.74088137
166neutral lipid catabolic process (GO:0046461)2.73906660
167acylglycerol catabolic process (GO:0046464)2.73906660
168endocytic recycling (GO:0032456)2.73327704
169purine nucleotide transport (GO:0015865)2.72977961
170mitochondrion localization (GO:0051646)2.71872456
171response to gravity (GO:0009629)2.71806069
172cellular polysaccharide catabolic process (GO:0044247)2.71313077
173respiratory system process (GO:0003016)2.70826900
174regulation of short-term neuronal synaptic plasticity (GO:0048172)2.70765854
175regulation of Rac GTPase activity (GO:0032314)2.70472930
176acyl-CoA biosynthetic process (GO:0071616)2.70134474
177thioester biosynthetic process (GO:0035384)2.70134474
178pyrimidine nucleotide catabolic process (GO:0006244)2.69920633
179segment specification (GO:0007379)2.69879782
180establishment of mitochondrion localization (GO:0051654)2.69398602
181positive regulation of mitochondrial fission (GO:0090141)2.69329445
182regulation of fatty acid biosynthetic process (GO:0042304)2.67934650
183regulation of synapse maturation (GO:0090128)2.67871159
184drug catabolic process (GO:0042737)2.67331201
185axoneme assembly (GO:0035082)2.66181243
186mannose metabolic process (GO:0006013)2.64117361
187response to misfolded protein (GO:0051788)2.62525615
188nucleotide transmembrane transport (GO:1901679)2.62221793
189maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.61371929
190tRNA modification (GO:0006400)2.61147440
191sex determination (GO:0007530)2.60942770
192positive regulation of adenylate cyclase activity (GO:0045762)2.60330536
193sphingosine metabolic process (GO:0006670)2.60302689
194ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.57785212
195nucleoside bisphosphate biosynthetic process (GO:0033866)2.57785212
196purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.57785212

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.76733557
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.09187879
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.92042815
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.09817377
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.49418443
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.41595644
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.18570148
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.09858737
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.99317530
10XRN2_22483619_ChIP-Seq_HELA_Human2.71861706
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.71525345
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.68930888
13LXR_22292898_ChIP-Seq_THP-1_Human2.64284174
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.51920263
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.48945084
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.32705971
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.23129825
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.16665331
19ZNF263_19887448_ChIP-Seq_K562_Human2.14417734
20* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11463079
21MAF_26560356_Chip-Seq_TH2_Human2.07119344
22FOXP1_21924763_ChIP-Seq_HESCs_Human1.97963601
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96012904
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94003110
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.83433652
26NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.76613929
27* TET1_21451524_ChIP-Seq_MESCs_Mouse1.72493593
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71735309
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.71336542
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69939000
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.66712369
32CTCF_20526341_ChIP-Seq_ESCs_Human1.64470131
33TP53_22127205_ChIP-Seq_IMR90_Human1.62226376
34* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61474801
35REST_21632747_ChIP-Seq_MESCs_Mouse1.54518391
36CTCF_27219007_Chip-Seq_Bcells_Human1.52336485
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.51302971
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.51090253
39* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50921062
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50698785
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.47400011
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.46505511
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45507084
44* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.45064900
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43103025
46ERA_21632823_ChIP-Seq_H3396_Human1.43022853
47* VDR_21846776_ChIP-Seq_THP-1_Human1.42572418
48GABP_19822575_ChIP-Seq_HepG2_Human1.42254148
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41258931
50* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40403318
51P68_20966046_ChIP-Seq_HELA_Human1.38267750
52MAF_26560356_Chip-Seq_TH1_Human1.37465932
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.37040807
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34252415
55* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.33755371
56* VDR_24763502_ChIP-Seq_THP-1_Human1.32839215
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32260874
58BCOR_27268052_Chip-Seq_Bcells_Human1.31946796
59* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.31840931
60* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31640206
61RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30041928
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29369569
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28905506
64RACK7_27058665_Chip-Seq_MCF-7_Human1.28761817
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26624118
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25950833
67JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25915923
68* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24704860
69BCL6_27268052_Chip-Seq_Bcells_Human1.24145614
70SMC4_20622854_ChIP-Seq_HELA_Human1.23200006
71SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23096053
72PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22384522
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21073790
74* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20712341
75* KDM2B_26808549_Chip-Seq_K562_Human1.19987231
76OCT4_19829295_ChIP-Seq_ESCs_Human1.19276275
77NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.19016925
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.18268488
79MYC_22102868_ChIP-Seq_BL_Human1.18043838
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17228761
81E2F1_20622854_ChIP-Seq_HELA_Human1.16283839
82UTX_26944678_Chip-Seq_JUKART_Human1.16276876
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16176615
84PHF8_20622854_ChIP-Seq_HELA_Human1.16028007
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.16009039
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15706900
87DROSHA_22980978_ChIP-Seq_HELA_Human1.15004143
88* KDM2B_26808549_Chip-Seq_DND41_Human1.14651532
89JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.13750198
90RARB_24833708_ChIP-Seq_LIVER_Mouse1.13324446
91* CIITA_25753668_ChIP-Seq_RAJI_Human1.12084633
92* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11223592
93CREB1_26743006_Chip-Seq_LNCaP_Human1.11186781
94SA1_27219007_Chip-Seq_Bcells_Human1.11069391
95* RARA_24833708_ChIP-Seq_LIVER_Mouse1.10226599
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.10078350
97TET1_21490601_ChIP-Seq_MESCs_Mouse1.09977649
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09689571
99ETS1_21867929_ChIP-Seq_TH2_Mouse1.09509771
100YY1_22570637_ChIP-Seq_MALME-3M_Human1.09214136
101SA1_27219007_Chip-Seq_ERYTHROID_Human1.09039054
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09018244
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08497336
104TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06723122
105SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06405397
106HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.06170722
107DCP1A_22483619_ChIP-Seq_HELA_Human1.06097636
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05946702
109POU5F1_16518401_ChIP-PET_MESCs_Mouse1.05586913
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04748681
111CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04180730
112GATA1_19941827_ChIP-Seq_MEL_Mouse1.03427336
113OCT4_20526341_ChIP-Seq_ESCs_Human1.03044018
114TCF7_22412390_ChIP-Seq_EML_Mouse1.02371964
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02130552
116SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01479418
117* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97613336
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97590462
119MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96925667
120* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96088441
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95782702
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95239132
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94838462
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93889221
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92809349
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91928364
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91760561
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91094815
129E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90571971
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90467677
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90271288
132CTCF_21964334_Chip-Seq_Bcells_Human0.89294565
133SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88662492
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87547362
135TP63_22573176_ChIP-Seq_HFKS_Human0.87376307
136SPI1_26923725_Chip-Seq_HPCs_Mouse0.86997057
137FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86812337
138TP53_20018659_ChIP-ChIP_R1E_Mouse0.86003677
139SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.85995030
140* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85963572
141MYC_27129775_Chip-Seq_CORNEA_Mouse0.85618313
142* CTCF_26484167_Chip-Seq_Bcells_Mouse0.84887470
143* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84655252

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation6.16884268
2MP0005423_abnormal_somatic_nervous6.11428410
3MP0001986_abnormal_taste_sensitivity5.42370507
4MP0002139_abnormal_hepatobiliary_system4.65334722
5MP0005360_urolithiasis4.49007241
6MP0005365_abnormal_bile_salt4.39582962
7MP0005085_abnormal_gallbladder_physiolo4.36030476
8MP0005174_abnormal_tail_pigmentation4.11504536
9MP0003136_yellow_coat_color3.97578638
10MP0002837_dystrophic_cardiac_calcinosis3.53488617
11MP0001188_hyperpigmentation3.52478968
12MP0001968_abnormal_touch/_nociception3.06076459
13MP0008875_abnormal_xenobiotic_pharmacok2.83132238
14MP0002638_abnormal_pupillary_reflex2.72373347
15MP0004233_abnormal_muscle_weight2.67835665
16MP0000751_myopathy2.54644242
17MP0004130_abnormal_muscle_cell2.42705459
18MP0003646_muscle_fatigue2.40390166
19MP0010329_abnormal_lipoprotein_level2.37789872
20MP0005409_darkened_coat_color2.36114412
21MP0002736_abnormal_nociception_after2.29207380
22MP0005670_abnormal_white_adipose2.21419847
23MP0005332_abnormal_amino_acid2.17919306
24MP0002160_abnormal_reproductive_system2.14605678
25MP0005083_abnormal_biliary_tract2.08018806
26MP0002735_abnormal_chemical_nociception2.06809603
27MP0009840_abnormal_foam_cell2.03508721
28MP0006036_abnormal_mitochondrial_physio1.99950627
29MP0001756_abnormal_urination1.98767536
30MP0003806_abnormal_nucleotide_metabolis1.98080521
31MP0000750_abnormal_muscle_regeneration1.95294250
32MP0005330_cardiomyopathy1.89195189
33MP0002118_abnormal_lipid_homeostasis1.86520957
34MP0003252_abnormal_bile_duct1.84287229
35MP0002909_abnormal_adrenal_gland1.81489332
36MP0002269_muscular_atrophy1.77341269
37MP0001661_extended_life_span1.73165313
38MP0003283_abnormal_digestive_organ1.68891497
39MP0004215_abnormal_myocardial_fiber1.68001875
40MP0006276_abnormal_autonomic_nervous1.64331866
41MP0004859_abnormal_synaptic_plasticity1.63707145
42MP0002822_catalepsy1.59394450
43MP0000538_abnormal_urinary_bladder1.58678286
44MP0003137_abnormal_impulse_conducting1.58066393
45MP0003195_calcinosis1.57374007
46MP0005535_abnormal_body_temperature1.55617604
47MP0000778_abnormal_nervous_system1.50298177
48MP0005319_abnormal_enzyme/_coenzyme1.49511147
49MP0000609_abnormal_liver_physiology1.49243083
50MP0001666_abnormal_nutrient_absorption1.49072128
51MP0004036_abnormal_muscle_relaxation1.48644778
52MP0008961_abnormal_basal_metabolism1.46287082
53MP0004270_analgesia1.44733415
54MP0005584_abnormal_enzyme/coenzyme_acti1.42916263
55MP0009046_muscle_twitch1.42682126
56MP0006072_abnormal_retinal_apoptosis1.42663209
57MP0001905_abnormal_dopamine_level1.40615689
58MP0003656_abnormal_erythrocyte_physiolo1.40528325
59MP0003191_abnormal_cellular_cholesterol1.37899398
60MP0002078_abnormal_glucose_homeostasis1.37817303
61MP0000015_abnormal_ear_pigmentation1.36049006
62MP0004084_abnormal_cardiac_muscle1.35580850
63MP0002971_abnormal_brown_adipose1.34764884
64MP0004019_abnormal_vitamin_homeostasis1.34014803
65MP0001970_abnormal_pain_threshold1.32483709
66MP0008775_abnormal_heart_ventricle1.31349857
67MP0001502_abnormal_circadian_rhythm1.31126228
68MP0005266_abnormal_metabolism1.29878634
69MP0005645_abnormal_hypothalamus_physiol1.27755158
70MP0003172_abnormal_lysosome_physiology1.27373748
71MP0003635_abnormal_synaptic_transmissio1.27285075
72MP0001919_abnormal_reproductive_system1.26739312
73MP0002332_abnormal_exercise_endurance1.23417722
74MP0003329_amyloid_beta_deposits1.22701396
75MP0000747_muscle_weakness1.22144430
76MP0004142_abnormal_muscle_tone1.18316174
77MP0001764_abnormal_homeostasis1.18019055
78MP0005666_abnormal_adipose_tissue1.17907495
79MP0002064_seizures1.17682830
80MP0005501_abnormal_skin_physiology1.17575163
81MP0005551_abnormal_eye_electrophysiolog1.16110831
82MP0000013_abnormal_adipose_tissue1.12848928
83MP0002063_abnormal_learning/memory/cond1.12509651
84MP0006035_abnormal_mitochondrial_morpho1.11719242
85MP0002572_abnormal_emotion/affect_behav1.09274994
86MP0003453_abnormal_keratinocyte_physiol1.08721719
87MP0000639_abnormal_adrenal_gland1.08629326
88MP0004087_abnormal_muscle_fiber1.06522579
89MP0001664_abnormal_digestion1.06097207
90MP0005334_abnormal_fat_pad1.05754531
91MP0002734_abnormal_mechanical_nocicepti1.05523542
92MP0005448_abnormal_energy_balance1.05519690
93MP0005058_abnormal_lysosome_morphology1.03880572
94MP0008874_decreased_physiological_sensi1.02902837
95MP0009115_abnormal_fat_cell0.99972181
96MP0003880_abnormal_central_pattern0.97754012
97MP0005257_abnormal_intraocular_pressure0.96921119
98MP0002970_abnormal_white_adipose0.95937510
99MP0004043_abnormal_pH_regulation0.95568800
100MP0001486_abnormal_startle_reflex0.94272965
101MP0004924_abnormal_behavior0.94090648
102MP0005386_behavior/neurological_phenoty0.94090648
103MP0005389_reproductive_system_phenotype0.92904938
104MP0003633_abnormal_nervous_system0.92636982
105MP0003959_abnormal_lean_body0.92429017
106MP0005375_adipose_tissue_phenotype0.91413981
107MP0005410_abnormal_fertilization0.91273994
108MP0003953_abnormal_hormone_level0.90669596
109MP0002272_abnormal_nervous_system0.90350131
110MP0000955_abnormal_spinal_cord0.90265412
111MP0003879_abnormal_hair_cell0.89638824
112MP0003075_altered_response_to0.89628019
113MP0003221_abnormal_cardiomyocyte_apopto0.89585577
114MP0008995_early_reproductive_senescence0.89532339
115MP0004381_abnormal_hair_follicle0.89107420
116MP0009745_abnormal_behavioral_response0.88805401
117MP0008872_abnormal_physiological_respon0.88755434
118MP0000749_muscle_degeneration0.88554083
119MP0003868_abnormal_feces_composition0.87701763
120MP0005253_abnormal_eye_physiology0.87492088
121MP0002090_abnormal_vision0.87449911
122MP0002557_abnormal_social/conspecific_i0.86751010
123MP0004811_abnormal_neuron_physiology0.85842854
124MP0002106_abnormal_muscle_physiology0.85486966
125MP0001958_emphysema0.85362817
126MP0008569_lethality_at_weaning0.84560297
127MP0003122_maternal_imprinting0.84062749
128MP0001324_abnormal_eye_pigmentation0.83534294
129MP0010630_abnormal_cardiac_muscle0.81208512
130MP0009278_abnormal_bone_marrow0.80783415
131MP0001529_abnormal_vocalization0.80768818
132MP0004145_abnormal_muscle_electrophysio0.80754760
133MP0002882_abnormal_neuron_morphology0.80699355
134MP0005376_homeostasis/metabolism_phenot0.80322731
135MP0000759_abnormal_skeletal_muscle0.79625506
136MP0002009_preneoplasia0.79357712
137MP0000003_abnormal_adipose_tissue0.78978295
138MP0001765_abnormal_ion_homeostasis0.77578392
139MP0010386_abnormal_urinary_bladder0.77470889
140MP0002733_abnormal_thermal_nociception0.77466949
141MP0005084_abnormal_gallbladder_morpholo0.76694701
142MP0009643_abnormal_urine_homeostasis0.73635183
143MP0000470_abnormal_stomach_morphology0.72870143
144MP0002249_abnormal_larynx_morphology0.72011541
145MP0005620_abnormal_muscle_contractility0.71958895
146MP0002067_abnormal_sensory_capabilities0.71350182
147MP0000604_amyloidosis0.71123279
148MP0005452_abnormal_adipose_tissue0.70695254
149MP0005220_abnormal_exocrine_pancreas0.69614610
150MP0002066_abnormal_motor_capabilities/c0.69504217
151MP0002152_abnormal_brain_morphology0.69066226
152MP0002752_abnormal_somatic_nervous0.68972564
153MP0004147_increased_porphyrin_level0.68862849
154MP0002184_abnormal_innervation0.68514660
155MP0000026_abnormal_inner_ear0.65923170
156MP0003111_abnormal_nucleus_morphology0.65501790
157MP0000358_abnormal_cell_content/0.57987641
158MP0003878_abnormal_ear_physiology0.57475967
159MP0005377_hearing/vestibular/ear_phenot0.57475967
160MP0005499_abnormal_olfactory_system0.57331470
161MP0005394_taste/olfaction_phenotype0.57331470
162MP0005195_abnormal_posterior_eye0.56210457
163MP0004133_heterotaxia0.55765474
164MP0001270_distended_abdomen0.52965194
165MP0002928_abnormal_bile_duct0.52904438
166MP0003787_abnormal_imprinting0.52360095

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.63788696
2Rib fusion (HP:0000902)6.47409305
3Attenuation of retinal blood vessels (HP:0007843)5.23974101
4Dyschromatopsia (HP:0007641)4.98004402
5Akinesia (HP:0002304)4.89292854
6Mesangial abnormality (HP:0001966)4.80389154
7Abnormality of aromatic amino acid family metabolism (HP:0004338)4.80385640
8Ulnar bowing (HP:0003031)4.68260239
9Fetal akinesia sequence (HP:0001989)4.66544305
10Ketoacidosis (HP:0001993)4.54969319
11Poikiloderma (HP:0001029)4.42959687
12Rectal fistula (HP:0100590)4.42544359
13Rectovaginal fistula (HP:0000143)4.42544359
14Ketosis (HP:0001946)4.38666413
15Facial hemangioma (HP:0000329)4.37622019
16Thin bony cortex (HP:0002753)4.33916637
17Vaginal fistula (HP:0004320)4.30300782
18Intestinal fistula (HP:0100819)4.01474508
19Increased hepatocellular lipid droplets (HP:0006565)3.96146194
20Hemorrhage of the eye (HP:0011885)3.82805482
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.82349485
22Bony spicule pigmentary retinopathy (HP:0007737)3.81002875
23Lipid accumulation in hepatocytes (HP:0006561)3.78962727
24Abnormality of the intrinsic pathway (HP:0010989)3.78315338
25Myoglobinuria (HP:0002913)3.78085331
26Hyperammonemia (HP:0001987)3.77674767
27Renal Fanconi syndrome (HP:0001994)3.76643928
28Exercise-induced myalgia (HP:0003738)3.73497766
29Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.73269111
30Hypoglycemic coma (HP:0001325)3.65774357
31Joint hemorrhage (HP:0005261)3.64756538
32Choroideremia (HP:0001139)3.60388787
33Popliteal pterygium (HP:0009756)3.59591615
34Aplasia of the musculature (HP:0100854)3.59252639
35Facial diplegia (HP:0001349)3.55370429
36Hyperglycinuria (HP:0003108)3.44791132
37Coronal craniosynostosis (HP:0004440)3.44463787
38Intrahepatic cholestasis (HP:0001406)3.40745732
39Myotonia (HP:0002486)3.39434200
40Decreased electroretinogram (ERG) amplitude (HP:0000654)3.35918838
41Xanthomatosis (HP:0000991)3.29315351
42Patellar aplasia (HP:0006443)3.29240503
43Hypobetalipoproteinemia (HP:0003563)3.24632959
44Anteriorly placed anus (HP:0001545)3.17752032
45Abnormality of glycine metabolism (HP:0010895)3.14160235
46Abnormality of serine family amino acid metabolism (HP:0010894)3.14160235
47Delayed epiphyseal ossification (HP:0002663)3.13566302
48Hyperglycinemia (HP:0002154)3.12614255
49Deep venous thrombosis (HP:0002625)3.11929609
50Decreased central vision (HP:0007663)3.11340358
51Asymmetric septal hypertrophy (HP:0001670)3.10699473
52Chorioretinal atrophy (HP:0000533)3.10636881
53Hyperlipoproteinemia (HP:0010980)3.09987218
54Aplasia/Hypoplasia of the patella (HP:0006498)3.09480277
55Squamous cell carcinoma (HP:0002860)3.04528550
56Abnormality of fatty-acid metabolism (HP:0004359)3.02509623
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.99568445
58Atrioventricular block (HP:0001678)2.96593523
59Neonatal respiratory distress (HP:0002643)2.96199097
60Turricephaly (HP:0000262)2.87698258
61Pancreatic islet-cell hyperplasia (HP:0004510)2.86295954
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.85479996
63Short chin (HP:0000331)2.79011535
64Growth hormone excess (HP:0000845)2.76365074
65Large for gestational age (HP:0001520)2.73403995
66Hypophosphatemic rickets (HP:0004912)2.73199676
67Hepatic necrosis (HP:0002605)2.71807328
68Increased muscle lipid content (HP:0009058)2.71738126
69Abnormality of dicarboxylic acid metabolism (HP:0010995)2.68541153
70Dicarboxylic aciduria (HP:0003215)2.68541153
71Abnormality of placental membranes (HP:0011409)2.67581612
72Amniotic constriction ring (HP:0009775)2.67581612
73Abnormal albumin level (HP:0012116)2.64416611
74Hypoalbuminemia (HP:0003073)2.64416611
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.64250170
76Pheochromocytoma (HP:0002666)2.62590499
77Urinary glycosaminoglycan excretion (HP:0003541)2.59339000
78Mucopolysacchariduria (HP:0008155)2.59339000
79Capillary hemangiomas (HP:0005306)2.59167516
80Cholecystitis (HP:0001082)2.58738635
81Abnormal gallbladder physiology (HP:0012438)2.58738635
82Bowing of the arm (HP:0006488)2.56800873
83Bowed forearm bones (HP:0003956)2.56800873
84Narrow nasal bridge (HP:0000446)2.56592779
85Prolonged partial thromboplastin time (HP:0003645)2.56368285
86Gout (HP:0001997)2.53212875
87Hypoglycemic seizures (HP:0002173)2.52557566
88Diminished movement (HP:0002374)2.52499183
89Hypolipoproteinemia (HP:0010981)2.48698339
90Sudden death (HP:0001699)2.48371205
91Choanal stenosis (HP:0000452)2.45322935
92Hypochromic microcytic anemia (HP:0004840)2.44959695
93Polycythemia (HP:0001901)2.43698934
94Cerebral edema (HP:0002181)2.42804829
95Abnormality of the costochondral junction (HP:0000919)2.42469744
96Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41826627
97Abnormality of polysaccharide metabolism (HP:0011012)2.41826627
98Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41826627
99Abnormality of the lower motor neuron (HP:0002366)2.41060956
100Abnormality of endocrine pancreas physiology (HP:0012093)2.38510980
101Abnormality of the pancreatic islet cells (HP:0006476)2.38510980
102Abnormal urine phosphate concentration (HP:0012599)2.38467847
103Lethargy (HP:0001254)2.37834573
104Enlarged epiphyses (HP:0010580)2.37623108
105Zonular cataract (HP:0010920)2.37490088
106Late onset (HP:0003584)2.35891768
107Annular pancreas (HP:0001734)2.35762241
108Delayed CNS myelination (HP:0002188)2.35743333
109Joint stiffness (HP:0001387)2.33768587
110Abnormality of glutamine family amino acid metabolism (HP:0010902)2.33639623
111Exertional dyspnea (HP:0002875)2.32290628
112Status epilepticus (HP:0002133)2.30989158
113Hyperinsulinemic hypoglycemia (HP:0000825)2.29418704
114Visual hallucinations (HP:0002367)2.29220029
115Hepatocellular necrosis (HP:0001404)2.28333295
116Rhabdomyolysis (HP:0003201)2.27797576
117Metabolic acidosis (HP:0001942)2.27156529
118Neuroendocrine neoplasm (HP:0100634)2.26982496
119Abnormal epiphyseal ossification (HP:0010656)2.26909593
120Increased intramyocellular lipid droplets (HP:0012240)2.24495284
121Cholelithiasis (HP:0001081)2.22394556
122Palpitations (HP:0001962)2.22392717
123Hypoalphalipoproteinemia (HP:0003233)2.22110285
124Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.21874366
125Widely patent fontanelles and sutures (HP:0004492)2.20221920
126Myokymia (HP:0002411)2.20001768
127Hypercortisolism (HP:0001578)2.19416310
128Dysostosis multiplex (HP:0000943)2.19272563
129Abnormality of renal resorption (HP:0011038)2.18908674
130Lower limb hyperreflexia (HP:0002395)2.17603676
131Acute encephalopathy (HP:0006846)2.17224854
132Generalized aminoaciduria (HP:0002909)2.15558964
133Pendular nystagmus (HP:0012043)2.13934420
134Acute hepatic failure (HP:0006554)2.12662818
135Central scotoma (HP:0000603)2.12654760
136Failure to thrive in infancy (HP:0001531)2.12504934
137Myopathic facies (HP:0002058)2.11479563
138Hyperbilirubinemia (HP:0002904)2.08764624
139Neonatal onset (HP:0003623)2.07716085
140Abnormal gallbladder morphology (HP:0012437)2.07062174
141Vomiting (HP:0002013)2.06450764
142Epiphyseal stippling (HP:0010655)2.06170743
143Congenital stationary night blindness (HP:0007642)2.05572491
144Ragged-red muscle fibers (HP:0003200)2.04439343
145Lactic acidosis (HP:0003128)2.04252043
146Complement deficiency (HP:0004431)2.03286088
147Respiratory difficulties (HP:0002880)2.03156590
148Abnormality of serum amino acid levels (HP:0003112)2.01686559
149Dysmetric saccades (HP:0000641)2.00583060
150Oligomenorrhea (HP:0000876)1.96587390
151Epidermoid cyst (HP:0200040)1.96426947
152Polyphagia (HP:0002591)1.94594166
153Flat occiput (HP:0005469)1.94448795
154Heart block (HP:0012722)1.93244323
155Muscle stiffness (HP:0003552)1.92458159
156Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92061034
157Fat malabsorption (HP:0002630)1.91152584
158Abnormal mitochondria in muscle tissue (HP:0008316)1.90382682
159Increased IgM level (HP:0003496)1.89035843
160Basal cell carcinoma (HP:0002671)1.88575161
161Absence seizures (HP:0002121)1.88199691
162Absent thumb (HP:0009777)1.87583569
163Abnormality of sulfur amino acid metabolism (HP:0004339)1.86440997
164Thin ribs (HP:0000883)1.86378606
165Premature graying of hair (HP:0002216)1.85889601
166Skin nodule (HP:0200036)1.85683578
167Spina bifida occulta (HP:0003298)1.85487274
168Aplasia/Hypoplasia involving the musculature (HP:0001460)1.84906507
169Abnormality of purine metabolism (HP:0004352)1.84905673
170CNS demyelination (HP:0007305)1.84625342
171Irritability (HP:0000737)1.84022811
172Abnormality of vision evoked potentials (HP:0000649)1.81777433
173Abnormal atrioventricular conduction (HP:0005150)1.81097575
174Increased number of teeth (HP:0011069)1.80831276
175Retinal dysplasia (HP:0007973)1.80647251
176Dysdiadochokinesis (HP:0002075)1.80616888
177Opisthotonus (HP:0002179)1.79469807
178Exercise-induced muscle cramps (HP:0003710)1.78819431
179Brushfield spots (HP:0001088)1.78485308
180Amblyopia (HP:0000646)1.74066310
181Mask-like facies (HP:0000298)1.68773993
182Short humerus (HP:0005792)1.67635355
183Rapidly progressive (HP:0003678)1.66351995
184Malignant hyperthermia (HP:0002047)1.66046373
185Polydipsia (HP:0001959)1.65712228
186Abnormal drinking behavior (HP:0030082)1.65712228

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.39311125
2PINK13.99900597
3WNK43.75828232
4BCKDK3.64604756
5MAP3K63.53623447
6MAPK153.46625076
7PHKG12.86033016
8PHKG22.86033016
9MAP3K112.82943027
10DDR22.53620734
11TLK12.41449358
12BLK2.33704654
13TRIB32.24567345
14DAPK12.21214734
15TESK22.11343575
16MAP3K91.96722147
17UHMK11.90815840
18PRKD21.88031944
19TRIM281.79854043
20TYRO31.65916642
21DYRK1B1.58319044
22SIK11.52360632
23MATK1.47451474
24PKN21.41614508
25FGR1.40410845
26IRAK21.38551144
27STK161.36589420
28GRK61.35117130
29MAP3K41.31308949
30ERN11.31282194
31DYRK21.29777958
32PRKAA11.27948151
33PDGFRA1.27789019
34NEK11.25832914
35PDK31.22601105
36PDK41.22601105
37BMX1.20117767
38CDK151.19584118
39CDK181.15790149
40CDK11A1.14642459
41MAP4K21.14499105
42INSRR1.14346093
43MAP2K41.14050248
44LMTK21.12217706
45ADRBK11.11396726
46PDPK11.07279347
47MAPK111.05814449
48EPHA41.04700984
49CSK1.04006273
50CDK141.03656130
51PRPF4B1.03602071
52PDK21.02359699
53CASK1.02289917
54PAK61.02237019
55ZAK1.01544166
56STK381.01318565
57RPS6KL11.01292151
58RPS6KC11.01292151
59PIM21.00844788
60ADRBK21.00563084
61AURKA0.99677665
62FLT30.98378428
63RPS6KA20.98230997
64CSNK1G30.94992686
65TNK20.92117760
66TAOK10.90796622
67CDC42BPA0.89103176
68MUSK0.86920259
69NTRK30.86687031
70PRKAA20.85452170
71CSNK1A1L0.84641196
72RPS6KA60.84516170
73HIPK20.81826142
74GSK3A0.81079249
75CSNK1G20.80466420
76DAPK20.80001417
77MAP2K60.78037296
78DYRK30.77336611
79TTN0.77112201
80SIK30.76468393
81CCNB10.75106487
82BMPR1B0.75065716
83KSR20.73961440
84LATS20.73184171
85CAMK2D0.72713900
86RAF10.72486017
87PAK10.71376979
88CAMK2A0.71294376
89CAMK2G0.71162335
90MAP3K70.70412082
91MINK10.69789563
92STK110.69696173
93WNK10.68831280
94TAOK20.66890220
95NTRK20.65516760
96CAMKK10.65503388
97RPS6KA50.64830983
98PRKD30.62737903
99PRKCH0.62023568
100SGK2230.61785050
101SGK4940.61785050
102PRKACG0.60653882
103MAPK130.58286010
104CSNK1D0.57991970
105NTRK10.57089896
106CDK50.56496242
107PRKCG0.55862054
108RIPK10.55144513
109JAK20.54624977
110MAP3K10.53462094
111CSNK1G10.53404799
112TBK10.52836181
113PRKCZ0.52772946
114MAPK80.51294108
115MARK20.50344495
116MAPK40.49351044
117MAP2K70.49197889
118TAOK30.48518834
119PRKD10.48300436
120SIK20.45428349
121BCR0.44810339
122CAMK2B0.44679548
123RPS6KA30.44554964
124PKN10.44274856
125CAMK40.44210209
126RPS6KA10.44143793
127EEF2K0.43644830
128CDK60.42559721
129CAMK10.41569383
130NEK20.41328743
131DAPK30.41228548
132SGK10.41065876
133CDK40.40504908
134AKT30.40066326
135MAPK120.40033277
136MYLK0.40017128
137OBSCN0.39934779
138MTOR0.39554587
139RPS6KB10.37919200
140CAMK1D0.37709811
141ARAF0.37475768
142CDK80.37189172
143MARK10.36933625
144STK390.36588988
145EPHB20.35609164
146MAP2K30.34776133
147PRKACA0.34734748
148CDK190.34159766
149SCYL20.34009072
150FGFR40.32683303
151YES10.31840459

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.57837102
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.56757654
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.34721430
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.94270023
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.91236767
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.83712738
7Arginine biosynthesis_Homo sapiens_hsa002202.75728129
8Fatty acid metabolism_Homo sapiens_hsa012122.68662680
9Propanoate metabolism_Homo sapiens_hsa006402.68654170
10Fatty acid biosynthesis_Homo sapiens_hsa000612.58091986
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.57561400
12Fatty acid degradation_Homo sapiens_hsa000712.52568003
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.50120699
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.43874683
15Nitrogen metabolism_Homo sapiens_hsa009102.42498178
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.37369659
17Butanoate metabolism_Homo sapiens_hsa006502.25840567
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21638993
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12404625
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07886265
21Tryptophan metabolism_Homo sapiens_hsa003802.05603545
22Sphingolipid metabolism_Homo sapiens_hsa006001.98096135
23Biosynthesis of amino acids_Homo sapiens_hsa012301.93757518
24Pyruvate metabolism_Homo sapiens_hsa006201.85134112
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84026322
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83487441
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81701564
28Carbon metabolism_Homo sapiens_hsa012001.78320599
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75287915
30PPAR signaling pathway_Homo sapiens_hsa033201.66168156
31Cocaine addiction_Homo sapiens_hsa050301.65564591
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.62968572
33Peroxisome_Homo sapiens_hsa041461.53610593
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.49998038
35beta-Alanine metabolism_Homo sapiens_hsa004101.49412368
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47149836
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.46492076
38Taste transduction_Homo sapiens_hsa047421.46075759
39Hedgehog signaling pathway_Homo sapiens_hsa043401.43850908
40Sulfur relay system_Homo sapiens_hsa041221.42394269
41Fatty acid elongation_Homo sapiens_hsa000621.36081436
42Arginine and proline metabolism_Homo sapiens_hsa003301.36034962
43Bile secretion_Homo sapiens_hsa049761.29418805
44Folate biosynthesis_Homo sapiens_hsa007901.22992820
45Cardiac muscle contraction_Homo sapiens_hsa042601.21194811
46Starch and sucrose metabolism_Homo sapiens_hsa005001.20511945
47Phenylalanine metabolism_Homo sapiens_hsa003601.06694042
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06359666
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.05496322
50Fructose and mannose metabolism_Homo sapiens_hsa000511.03329333
51Circadian rhythm_Homo sapiens_hsa047101.01143097
52GABAergic synapse_Homo sapiens_hsa047270.99583136
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98528645
54Synaptic vesicle cycle_Homo sapiens_hsa047210.98203296
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97378934
56Oxidative phosphorylation_Homo sapiens_hsa001900.95912700
57Axon guidance_Homo sapiens_hsa043600.94734992
58Lysine degradation_Homo sapiens_hsa003100.93117333
59Selenocompound metabolism_Homo sapiens_hsa004500.92911154
60Parkinsons disease_Homo sapiens_hsa050120.92282662
61Complement and coagulation cascades_Homo sapiens_hsa046100.91400465
62ABC transporters_Homo sapiens_hsa020100.91124688
63Phototransduction_Homo sapiens_hsa047440.87508998
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83447635
65Other glycan degradation_Homo sapiens_hsa005110.83174842
66Ovarian steroidogenesis_Homo sapiens_hsa049130.81981982
67Fanconi anemia pathway_Homo sapiens_hsa034600.81799531
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.81640278
69Basal transcription factors_Homo sapiens_hsa030220.80909311
70Nicotine addiction_Homo sapiens_hsa050330.80465424
71Alcoholism_Homo sapiens_hsa050340.80232399
72Glycerolipid metabolism_Homo sapiens_hsa005610.79912391
73Cholinergic synapse_Homo sapiens_hsa047250.78924753
74Galactose metabolism_Homo sapiens_hsa000520.78369925
75Fat digestion and absorption_Homo sapiens_hsa049750.77966123
76Lysosome_Homo sapiens_hsa041420.77342999
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75931073
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73355185
79Tyrosine metabolism_Homo sapiens_hsa003500.72897927
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72712351
81Hippo signaling pathway_Homo sapiens_hsa043900.72052856
82Sulfur metabolism_Homo sapiens_hsa009200.70750960
83Glucagon signaling pathway_Homo sapiens_hsa049220.70687861
84Melanogenesis_Homo sapiens_hsa049160.69249073
85Gap junction_Homo sapiens_hsa045400.68460467
86Steroid biosynthesis_Homo sapiens_hsa001000.68207159
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67565717
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.67215358
89Insulin secretion_Homo sapiens_hsa049110.65183098
90Histidine metabolism_Homo sapiens_hsa003400.63649660
91Dopaminergic synapse_Homo sapiens_hsa047280.63577008
92Chemical carcinogenesis_Homo sapiens_hsa052040.63129481
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63112700
94Alzheimers disease_Homo sapiens_hsa050100.61636958
95Calcium signaling pathway_Homo sapiens_hsa040200.61422303
96Insulin signaling pathway_Homo sapiens_hsa049100.60476030
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59691373
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59372274
99AMPK signaling pathway_Homo sapiens_hsa041520.57992199
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57400171
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57014731
102Caffeine metabolism_Homo sapiens_hsa002320.56075307
103Inositol phosphate metabolism_Homo sapiens_hsa005620.55378554
104RNA polymerase_Homo sapiens_hsa030200.54953455
105mTOR signaling pathway_Homo sapiens_hsa041500.54818504
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.54634591
107Endocytosis_Homo sapiens_hsa041440.54147116
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.52353486
109Notch signaling pathway_Homo sapiens_hsa043300.51955711
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51632703
111Base excision repair_Homo sapiens_hsa034100.50719534
112Morphine addiction_Homo sapiens_hsa050320.50379468
113Pentose phosphate pathway_Homo sapiens_hsa000300.49568681
114Vitamin digestion and absorption_Homo sapiens_hsa049770.49350470
115VEGF signaling pathway_Homo sapiens_hsa043700.47394733
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.46885262
117Basal cell carcinoma_Homo sapiens_hsa052170.46853346
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45852482
119Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45281776
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45025779
121Metabolic pathways_Homo sapiens_hsa011000.44181525
122Retinol metabolism_Homo sapiens_hsa008300.43533878
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42685150
124Insulin resistance_Homo sapiens_hsa049310.41793325
125N-Glycan biosynthesis_Homo sapiens_hsa005100.41706779
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41387851
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37080192
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36962539
129Circadian entrainment_Homo sapiens_hsa047130.35899001
130Vibrio cholerae infection_Homo sapiens_hsa051100.35385696
131cAMP signaling pathway_Homo sapiens_hsa040240.34720407
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.33293230
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33241177
134Olfactory transduction_Homo sapiens_hsa047400.33028401
135Huntingtons disease_Homo sapiens_hsa050160.31973384
136Dilated cardiomyopathy_Homo sapiens_hsa054140.31419359
137Type II diabetes mellitus_Homo sapiens_hsa049300.31066025
138Salivary secretion_Homo sapiens_hsa049700.30884840
139Renin secretion_Homo sapiens_hsa049240.29560837
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27922876
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22873904
142Glutamatergic synapse_Homo sapiens_hsa047240.22540227
143Serotonergic synapse_Homo sapiens_hsa047260.22350265
144Bladder cancer_Homo sapiens_hsa052190.22248176
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.22142031
146Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21728418
147Amphetamine addiction_Homo sapiens_hsa050310.21392215
148Phosphatidylinositol signaling system_Homo sapiens_hsa040700.20696328
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20344270
150Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20256037
151Pyrimidine metabolism_Homo sapiens_hsa002400.18570185
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17271746
153Regulation of autophagy_Homo sapiens_hsa041400.14449325

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