LRRC25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)7.58549353
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:007.58549353
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:07.58549353
4positive regulation by organism of defense response of other organism involved in symbiotic interact7.58549353
5modulation by symbiont of host immune response (GO:0052553)7.58549353
6positive regulation by symbiont of host defense response (GO:0052509)7.58549353
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.35806959
8negative regulation of cell killing (GO:0031342)6.35806959
9response to peptidoglycan (GO:0032494)5.83989405
10neutrophil activation involved in immune response (GO:0002283)5.53512993
11regulation of interferon-beta biosynthetic process (GO:0045357)5.52958814
12macrophage activation involved in immune response (GO:0002281)5.46403872
13detection of other organism (GO:0098543)5.34882966
14detection of bacterium (GO:0016045)5.12703797
15positive regulation of interferon-alpha production (GO:0032727)5.05448803
16response to host immune response (GO:0052572)5.02195806
17response to immune response of other organism involved in symbiotic interaction (GO:0052564)5.02195806
18respiratory burst (GO:0045730)4.96721381
19immunoglobulin mediated immune response (GO:0016064)4.96648593
20regulation of interferon-alpha production (GO:0032647)4.86884007
21positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.78477676
22detection of external biotic stimulus (GO:0098581)4.57989856
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54661724
24response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.53945827
25response to host (GO:0075136)4.53945827
26response to host defenses (GO:0052200)4.53945827
27microglial cell activation (GO:0001774)4.52590080
28positive regulation of chemokine biosynthetic process (GO:0045080)4.46201752
29negative regulation of lymphocyte mediated immunity (GO:0002707)4.19519802
30leukocyte migration involved in inflammatory response (GO:0002523)4.19170853
31regulation of gamma-delta T cell activation (GO:0046643)4.18269885
32lipopolysaccharide-mediated signaling pathway (GO:0031663)4.15356072
33positive regulation of antigen processing and presentation (GO:0002579)4.12686395
34detection of biotic stimulus (GO:0009595)4.04343161
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.92928510
36macrophage activation (GO:0042116)3.91264396
37regulation of B cell receptor signaling pathway (GO:0050855)3.90957569
38hydrogen peroxide biosynthetic process (GO:0050665)3.90057044
39granulocyte activation (GO:0036230)3.85260289
40regulation of dendritic cell antigen processing and presentation (GO:0002604)3.85092577
41positive regulation of mast cell activation (GO:0033005)3.84026463
42myeloid cell activation involved in immune response (GO:0002275)3.83307293
43positive regulation of mast cell activation involved in immune response (GO:0033008)3.78617793
44positive regulation of mast cell degranulation (GO:0043306)3.78617793
45negative regulation of leukocyte mediated immunity (GO:0002704)3.75912362
46response to muramyl dipeptide (GO:0032495)3.75091213
47neutrophil activation (GO:0042119)3.71750071
48regulation of mast cell degranulation (GO:0043304)3.71596990
49negative regulation of T cell mediated immunity (GO:0002710)3.61930970
50reactive oxygen species biosynthetic process (GO:1903409)3.61370840
51negative regulation of interleukin-12 production (GO:0032695)3.60569784
52B cell mediated immunity (GO:0019724)3.59188029
53positive regulation of interferon-beta production (GO:0032728)3.58613447
54response to interleukin-15 (GO:0070672)3.58322054
55regulation of interleukin-8 biosynthetic process (GO:0045414)3.57531496
56negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.56915962
57regulation of chemokine biosynthetic process (GO:0045073)3.55211434
58cellular extravasation (GO:0045123)3.53272759
59production of molecular mediator involved in inflammatory response (GO:0002532)3.52692699
60superoxide anion generation (GO:0042554)3.49313637
61regulation of antigen processing and presentation (GO:0002577)3.48592768
62regulation of mast cell activation involved in immune response (GO:0033006)3.47932954
63regulation of gamma-delta T cell differentiation (GO:0045586)3.45377967
64regulation of T cell tolerance induction (GO:0002664)3.44381691
65regulation of mononuclear cell migration (GO:0071675)3.41281242
66antigen processing and presentation via MHC class Ib (GO:0002475)3.38634398
67detection of molecule of bacterial origin (GO:0032490)3.38082532
68regulation of mast cell activation (GO:0033003)3.36718235
69regulation of tolerance induction (GO:0002643)3.34221849
70type I interferon signaling pathway (GO:0060337)3.33609872
71cellular response to type I interferon (GO:0071357)3.33609872
72neutrophil mediated immunity (GO:0002446)3.32830778
73positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.32592975
74leukocyte aggregation (GO:0070486)3.30787086
75I-kappaB phosphorylation (GO:0007252)3.30640601
76response to type I interferon (GO:0034340)3.30179338
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.28249646
78negative regulation of erythrocyte differentiation (GO:0045647)3.28099252
79positive regulation of cellular amide metabolic process (GO:0034250)3.27756216
80leukocyte degranulation (GO:0043299)3.25787788
81cellular response to interleukin-15 (GO:0071350)3.25629344
82antigen processing and presentation of endogenous antigen (GO:0019883)3.25473729
83antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23395059
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23395059
85positive regulation of toll-like receptor signaling pathway (GO:0034123)3.23298447
86regulation of regulated secretory pathway (GO:1903305)3.23278524
87positive regulation of leukocyte degranulation (GO:0043302)3.21817971
88positive regulation of gamma-delta T cell activation (GO:0046645)3.21789796
89regulation of podosome assembly (GO:0071801)3.20909426
90positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.19835945
91B cell receptor signaling pathway (GO:0050853)3.18504758
92positive regulation of B cell differentiation (GO:0045579)3.18448974
93low-density lipoprotein particle clearance (GO:0034383)3.18330461
94positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.16688037
95interferon-gamma-mediated signaling pathway (GO:0060333)3.16131440
96positive regulation of heat generation (GO:0031652)3.15555572
97regulation of T-helper 2 cell differentiation (GO:0045628)3.14955897
98regulation of B cell differentiation (GO:0045577)3.14506849
99regulation of leukocyte degranulation (GO:0043300)3.13371678
100negative regulation of phagocytosis (GO:0050765)3.12985102
101lymphocyte chemotaxis (GO:0048247)3.11922618
102positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.10402596
103regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07787702
104myeloid leukocyte mediated immunity (GO:0002444)3.07265523
105defense response to protozoan (GO:0042832)3.06936293
106regulation of cholesterol storage (GO:0010885)3.04877552
107negative regulation of cytokine production involved in immune response (GO:0002719)3.04519467
108negative regulation of myeloid cell apoptotic process (GO:0033033)3.04062848
109regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.02737628
110positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.02722312
111positive regulation of chemokine production (GO:0032722)3.01373796
112negative regulation of interleukin-6 production (GO:0032715)3.01089649
113neutrophil chemotaxis (GO:0030593)2.99463635
114regulation of T cell mediated cytotoxicity (GO:0001914)2.98114534
115leukocyte mediated cytotoxicity (GO:0001909)2.97973149
116regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97493035
117pinocytosis (GO:0006907)2.95115333
118regulation of natural killer cell mediated immunity (GO:0002715)2.94293084
119regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.94293084
120negative regulation of mast cell activation (GO:0033004)2.92954541
121myeloid leukocyte activation (GO:0002274)2.92174954
122germinal center formation (GO:0002467)2.91894239
123negative regulation of innate immune response (GO:0045824)2.91212775
124neutrophil migration (GO:1990266)2.90851607
125regulation of fever generation (GO:0031620)2.88813689
126negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.88246620
127negative regulation of T-helper cell differentiation (GO:0045623)2.88246620
128negative regulation of alpha-beta T cell activation (GO:0046636)2.88187316
129T-helper 1 type immune response (GO:0042088)2.88101710
130Arp2/3 complex-mediated actin nucleation (GO:0034314)2.85032203
131positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.84377257
132positive regulation of tumor necrosis factor production (GO:0032760)2.84328675
133myeloid dendritic cell differentiation (GO:0043011)2.84306442
134natural killer cell mediated cytotoxicity (GO:0042267)2.80304794
135natural killer cell mediated immunity (GO:0002228)2.80304794
136negative regulation of growth of symbiont in host (GO:0044130)2.79277618
137negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.79277618
138modulation of growth of symbiont involved in interaction with host (GO:0044144)2.79277618
139regulation of growth of symbiont in host (GO:0044126)2.79277618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.20388034
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.44286255
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.12836081
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.74772485
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.35853970
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.88082539
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.76562783
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.66907844
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.55252139
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.45105635
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.25051560
12MYB_21317192_ChIP-Seq_ERMYB_Mouse3.24855688
13* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.78864332
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.77481120
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.72792733
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72470673
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69297233
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.48118069
19* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.41157553
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.30575291
21* SPI1_23547873_ChIP-Seq_NB4_Human2.27263123
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.16988216
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.02186385
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00679747
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98943888
26VDR_24763502_ChIP-Seq_THP-1_Human1.97108155
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93647643
28SPI1_23127762_ChIP-Seq_K562_Human1.93044096
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.84108067
30CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.80796502
31VDR_21846776_ChIP-Seq_THP-1_Human1.77601627
32PU_27001747_Chip-Seq_BMDM_Mouse1.77112093
33SCL_19346495_ChIP-Seq_HPC-7_Human1.75831036
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73755274
35CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.72686336
36VDR_24787735_ChIP-Seq_THP-1_Human1.63527740
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63248408
38MAF_26560356_Chip-Seq_TH1_Human1.61941386
39MYB_26560356_Chip-Seq_TH2_Human1.61919267
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61842573
41RUNX_20019798_ChIP-Seq_JUKART_Human1.55394138
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51604368
43* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50774764
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48638365
45GATA1_22025678_ChIP-Seq_K562_Human1.48637109
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.40945217
47* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40500087
48* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40176611
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39526703
50* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38182595
51* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38121556
52MYB_26560356_Chip-Seq_TH1_Human1.31906280
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31764870
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31431992
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30032899
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29088536
57UTX_26944678_Chip-Seq_JUKART_Human1.27378087
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24935923
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24741593
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22291140
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.18144950
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17325187
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17089078
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15963923
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14108161
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.13333093
67GATA3_27048872_Chip-Seq_THYMUS_Human1.11558939
68* TCF7_22412390_ChIP-Seq_EML_Mouse1.11478797
69GATA3_26560356_Chip-Seq_TH2_Human1.08389896
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05891019
71* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03035757
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.02003284
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01455421
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01393245
75GATA1_19941827_ChIP-Seq_MEL_Mouse0.99029426
76MYC_22102868_ChIP-Seq_BL_Human0.98535845
77SPI1_20517297_ChIP-Seq_HL60_Human0.98267542
78LXR_22292898_ChIP-Seq_THP-1_Human0.95161124
79EGR1_19032775_ChIP-ChIP_M12_Human0.94778710
80* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94737092
81MAF_26560356_Chip-Seq_TH2_Human0.94641925
82GATA1_19941826_ChIP-Seq_K562_Human0.93186032
83* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92975550
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92881215
85ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92486628
86* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90672463
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89520196
88GATA2_19941826_ChIP-Seq_K562_Human0.86449409
89KDM2B_26808549_Chip-Seq_DND41_Human0.85565842
90* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84623726
91TFEB_21752829_ChIP-Seq_HELA_Human0.83441154
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81625816
93* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81231449
94PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80911387
95* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80803461
96NCOR1_26117541_ChIP-Seq_K562_Human0.80401293
97* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79257356
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.79083912
99IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79037712
100RXR_22158963_ChIP-Seq_LIVER_Mouse0.78558605
101GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77569234
102ELF1_20517297_ChIP-Seq_JURKAT_Human0.77532004
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73001252
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72298302
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.72019167
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71240871
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69418187
108RARG_19884340_ChIP-ChIP_MEFs_Mouse0.69060322
109BCL6_27268052_Chip-Seq_Bcells_Human0.66285997
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64594317
111EGR1_23403033_ChIP-Seq_LIVER_Mouse0.63018382
112* BCOR_27268052_Chip-Seq_Bcells_Human0.62381076
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.62304299

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.19904692
2MP0003303_peritoneal_inflammation4.11214186
3MP0003436_decreased_susceptibility_to4.06000545
4MP0009785_altered_susceptibility_to3.60662757
5MP0005058_abnormal_lysosome_morphology3.53133946
6MP0002419_abnormal_innate_immunity3.37138955
7MP0006082_CNS_inflammation3.31407537
8MP0002148_abnormal_hypersensitivity_rea3.18734627
9MP0005000_abnormal_immune_tolerance3.08572040
10MP0003724_increased_susceptibility_to2.96210624
11MP0005025_abnormal_response_to2.95463701
12MP0001790_abnormal_immune_system2.83253817
13MP0005387_immune_system_phenotype2.83253817
14MP0002452_abnormal_antigen_presenting2.57426985
15MP0004510_myositis2.57129311
16MP0003172_abnormal_lysosome_physiology2.47854084
17MP0001800_abnormal_humoral_immune2.47279469
18MP0002723_abnormal_immune_serum2.38758389
19MP0000685_abnormal_immune_system2.36440865
20MP0001533_abnormal_skeleton_physiology2.35905353
21MP0009840_abnormal_foam_cell2.33162673
22MP0005671_abnormal_response_to2.32435692
23MP0005464_abnormal_platelet_physiology2.29226476
24MP0001819_abnormal_immune_cell2.14110367
25MP0002420_abnormal_adaptive_immunity2.11130080
26MP0000343_altered_response_to2.06313722
27MP0004947_skin_inflammation1.95936952
28MP0009278_abnormal_bone_marrow1.95828813
29MP0001845_abnormal_inflammatory_respons1.93808724
30MP0002405_respiratory_system_inflammati1.91865702
31MP0003075_altered_response_to1.90613823
32MP0003191_abnormal_cellular_cholesterol1.88857199
33MP0000604_amyloidosis1.85700501
34MP0008469_abnormal_protein_level1.80176207
35MP0009764_decreased_sensitivity_to1.75728654
36MP0001853_heart_inflammation1.74748831
37MP0002132_abnormal_respiratory_system1.72175913
38MP0003448_altered_tumor_morphology1.71746038
39MP0003763_abnormal_thymus_physiology1.71259285
40MP0003300_gastrointestinal_ulcer1.66437519
41MP0009333_abnormal_splenocyte_physiolog1.64465976
42MP0010155_abnormal_intestine_physiology1.57476539
43MP0003183_abnormal_peptide_metabolism1.50141966
44MP0000716_abnormal_immune_system1.49026887
45MP0003690_abnormal_glial_cell1.44313821
46MP0005167_abnormal_blood-brain_barrier1.42596479
47MP0004858_abnormal_nervous_system1.41084884
48MP0003866_abnormal_defecation1.39375541
49MP0002998_abnormal_bone_remodeling1.37103300
50MP0005310_abnormal_salivary_gland1.36496797
51MP0005166_decreased_susceptibility_to1.35772784
52MP0002398_abnormal_bone_marrow1.35358707
53MP0005397_hematopoietic_system_phenotyp1.31705751
54MP0001545_abnormal_hematopoietic_system1.31705751
55MP0002006_tumorigenesis1.29841172
56MP0000689_abnormal_spleen_morphology1.27812019
57MP0000858_altered_metastatic_potential1.22126327
58MP0002429_abnormal_blood_cell1.20085123
59MP0000703_abnormal_thymus_morphology1.18420839
60MP0002396_abnormal_hematopoietic_system1.17816001
61MP0004381_abnormal_hair_follicle1.16667432
62MP0003806_abnormal_nucleotide_metabolis1.11753716
63MP0001851_eye_inflammation1.11385006
64MP0010307_abnormal_tumor_latency1.10890695
65MP0002166_altered_tumor_susceptibility1.09868635
66MP0002722_abnormal_immune_system1.09757486
67MP0005390_skeleton_phenotype1.07619234
68MP0005164_abnormal_response_to1.05556486
69MP0002933_joint_inflammation1.04963079
70MP0005083_abnormal_biliary_tract1.04833084
71MP0009763_increased_sensitivity_to1.03628497
72MP0005076_abnormal_cell_differentiation1.03110912
73MP0003828_pulmonary_edema1.02513128
74MP0002277_abnormal_respiratory_mucosa1.00923041
75MP0005257_abnormal_intraocular_pressure0.97193056
76MP0004782_abnormal_surfactant_physiolog0.96193078
77MP0003656_abnormal_erythrocyte_physiolo0.95113269
78MP0003566_abnormal_cell_adhesion0.92882316
79MP0000465_gastrointestinal_hemorrhage0.92722263
80MP0003186_abnormal_redox_activity0.92422625
81MP0000569_abnormal_digit_pigmentation0.92224552
82MP0008004_abnormal_stomach_pH0.89530336
83MP0000249_abnormal_blood_vessel0.83103668
84MP0008260_abnormal_autophagy0.81169592
85MP0001986_abnormal_taste_sensitivity0.78810160
86MP0003195_calcinosis0.75133867
87MP0008438_abnormal_cutaneous_collagen0.73090499
88MP0005174_abnormal_tail_pigmentation0.72179565
89MP0000015_abnormal_ear_pigmentation0.71359346
90MP0005075_abnormal_melanosome_morpholog0.70849124
91MP0005023_abnormal_wound_healing0.68491357
92MP0003795_abnormal_bone_structure0.68444850
93MP0000490_abnormal_crypts_of0.67737957
94MP0003453_abnormal_keratinocyte_physiol0.67236020
95MP0009765_abnormal_xenobiotic_induced0.66433767
96MP0003045_fibrosis0.66139356
97MP0001958_emphysema0.64777474
98MP0008874_decreased_physiological_sensi0.64505921
99MP0000609_abnormal_liver_physiology0.64252889
100MP0002138_abnormal_hepatobiliary_system0.62587991
101MP0005319_abnormal_enzyme/_coenzyme0.62533427
102MP0004883_abnormal_blood_vessel0.62345543
103MP0002136_abnormal_kidney_physiology0.61617330
104MP0005584_abnormal_enzyme/coenzyme_acti0.57392352
105MP0004808_abnormal_hematopoietic_stem0.57253652
106MP0001873_stomach_inflammation0.56839192
107MP0000920_abnormal_myelination0.56777728
108MP0003705_abnormal_hypodermis_morpholog0.56560346
109MP0005451_abnormal_body_composition0.56480144
110MP0004130_abnormal_muscle_cell0.55895054
111MP0008873_increased_physiological_sensi0.55270760
112MP0001663_abnormal_digestive_system0.55188424
113MP0003091_abnormal_cell_migration0.54014639
114MP0002090_abnormal_vision0.52601876
115MP0000371_diluted_coat_color0.52485148
116MP0000767_abnormal_smooth_muscle0.52408940
117MP0002332_abnormal_exercise_endurance0.51198147
118MP0003329_amyloid_beta_deposits0.49647934
119MP0002693_abnormal_pancreas_physiology0.47460381
120MP0002133_abnormal_respiratory_system0.47103069
121MP0005388_respiratory_system_phenotype0.47103069
122MP0003221_abnormal_cardiomyocyte_apopto0.46976335
123MP0003878_abnormal_ear_physiology0.46149076
124MP0005377_hearing/vestibular/ear_phenot0.46149076

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.59397699
2Recurrent bacterial skin infections (HP:0005406)6.72852292
3Eczematoid dermatitis (HP:0000976)6.59737959
4Recurrent gram-negative bacterial infections (HP:0005420)6.26111659
5Systemic lupus erythematosus (HP:0002725)5.87990444
6Increased cerebral lipofuscin (HP:0011813)5.44681938
7Abnormality of macrophages (HP:0004311)5.30243197
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.89230349
9Vacuolated lymphocytes (HP:0001922)4.86813462
10Mediastinal lymphadenopathy (HP:0100721)4.60593652
11Elevated erythrocyte sedimentation rate (HP:0003565)4.23649701
12Myositis (HP:0100614)4.22843004
13Glomerulonephritis (HP:0000099)4.10161728
14Orchitis (HP:0100796)4.09300835
15Gingivitis (HP:0000230)4.06449930
16Stomatitis (HP:0010280)4.06272979
17Obstructive lung disease (HP:0006536)4.03774118
18Chronic obstructive pulmonary disease (HP:0006510)4.03774118
19Gastrointestinal infarctions (HP:0005244)3.98972426
20Recurrent skin infections (HP:0001581)3.94778226
21Autoimmune thrombocytopenia (HP:0001973)3.88124849
22Abnormality of liposaccharide metabolism (HP:0010968)3.76344173
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.76344173
24Abnormality of glycolipid metabolism (HP:0010969)3.76344173
25Dysostosis multiplex (HP:0000943)3.75660335
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.70996115
27Encephalitis (HP:0002383)3.64554055
28Retrobulbar optic neuritis (HP:0100654)3.62219523
29Optic neuritis (HP:0100653)3.62219523
30Axonal loss (HP:0003447)3.58643920
31Disinhibition (HP:0000734)3.44871426
32Hypochromic microcytic anemia (HP:0004840)3.41650010
33Increased IgE level (HP:0003212)3.31017622
34Recurrent fungal infections (HP:0002841)3.25978864
35Prolonged bleeding time (HP:0003010)3.24214319
36Pustule (HP:0200039)3.20895272
37Urticaria (HP:0001025)3.17263988
38Episodic fever (HP:0001954)3.16163766
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.15695096
40Vasculitis (HP:0002633)3.11263040
41Loss of speech (HP:0002371)3.09479007
42Urinary glycosaminoglycan excretion (HP:0003541)3.08782489
43Mucopolysacchariduria (HP:0008155)3.08782489
44Chest pain (HP:0100749)3.08734528
45Abnormality of complement system (HP:0005339)3.05843014
46Hypochromic anemia (HP:0001931)2.99668941
47Prostate neoplasm (HP:0100787)2.96147603
48Cellulitis (HP:0100658)2.95366126
49Thick nail (HP:0001805)2.94754824
50Periodontitis (HP:0000704)2.88969623
51Abnormality of polysaccharide metabolism (HP:0011012)2.88810947
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.88810947
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.88810947
54Recurrent viral infections (HP:0004429)2.87564148
55Complement deficiency (HP:0004431)2.84378170
56Basal ganglia calcification (HP:0002135)2.74435991
57Nephritis (HP:0000123)2.73404644
58Interstitial pulmonary disease (HP:0006530)2.72474709
59T lymphocytopenia (HP:0005403)2.71488354
60Epistaxis (HP:0000421)2.70021341
61Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.68947687
62Pulmonary embolism (HP:0002204)2.68271896
63Chronic otitis media (HP:0000389)2.65041382
64Pulmonary infiltrates (HP:0002113)2.64893409
65Meningitis (HP:0001287)2.61585234
66Hepatosplenomegaly (HP:0001433)2.60722501
67Purpura (HP:0000979)2.60400865
68Abnormality of T cell number (HP:0011839)2.59977200
69Myocardial infarction (HP:0001658)2.59481181
70Hematochezia (HP:0002573)2.57475501
71Spontaneous hematomas (HP:0007420)2.56628082
72Agnosia (HP:0010524)2.55206867
73Gastrointestinal inflammation (HP:0004386)2.53984761
74Panhypogammaglobulinemia (HP:0003139)2.40057782
75Osteomyelitis (HP:0002754)2.35720559
76Tetraparesis (HP:0002273)2.34701511
77Abnormality of T cells (HP:0002843)2.34250061
78Leukocytosis (HP:0001974)2.32809071
79Increased IgM level (HP:0003496)2.31048469
80Arterial thrombosis (HP:0004420)2.30302116
81Recurrent pneumonia (HP:0006532)2.29595439
82Gangrene (HP:0100758)2.28534106
83Microcytic anemia (HP:0001935)2.26572670
84Upper motor neuron abnormality (HP:0002127)2.24924263
85Amyloidosis (HP:0011034)2.24714385
86Keratoconjunctivitis sicca (HP:0001097)2.23809757
87Sepsis (HP:0100806)2.23568979
88Joint hemorrhage (HP:0005261)2.21777684
89Granulocytopenia (HP:0001913)2.21670719
90J-shaped sella turcica (HP:0002680)2.20292375
91Gingival bleeding (HP:0000225)2.18235951
92Abnormality of iron homeostasis (HP:0011031)2.17153907
93Lymphopenia (HP:0001888)2.16935355
94Petechiae (HP:0000967)2.16766779
95Pathologic fracture (HP:0002756)2.13728941
96Osteolytic defects of the phalanges of the hand (HP:0009771)2.13155459
97Osteolytic defects of the hand bones (HP:0009699)2.13155459
98Chronic mucocutaneous candidiasis (HP:0002728)2.11390631
99Recurrent cutaneous fungal infections (HP:0011370)2.11390631
100Vertigo (HP:0002321)2.09641420
101Glomerulopathy (HP:0100820)2.08696065
102Poor head control (HP:0002421)2.06701849
103Abnormality of the endocardium (HP:0004306)2.06462536
104Polyneuropathy (HP:0001271)2.05184072
105Hemoptysis (HP:0002105)2.04824421
106Premature loss of primary teeth (HP:0006323)2.04577719
107Peritonitis (HP:0002586)2.03835908
108Acne (HP:0001061)2.03025689
109Hypergammaglobulinemia (HP:0010702)2.01922673
110Abnormality of the prostate (HP:0008775)2.01191115
111Nasal polyposis (HP:0100582)2.00461973
112Colitis (HP:0002583)2.00457467
113Abnormality of the peritoneum (HP:0002585)2.00218640
114Keratoconjunctivitis (HP:0001096)2.00073723
115Recurrent lower respiratory tract infections (HP:0002783)1.99971141
116Anorexia (HP:0002039)1.99927631
117Bone pain (HP:0002653)1.99099840
118Abnormality of cells of the lymphoid lineage (HP:0012140)1.98754840
119Abnormality of T cell physiology (HP:0011840)1.98077155
120Esophageal neoplasm (HP:0100751)1.96751064
121Neoplasm of head and neck (HP:0012288)1.96751064
122Abnormality of the nasal mucosa (HP:0000433)1.95765861
123Inflammation of the large intestine (HP:0002037)1.95475524
124Abnormality of the pericardium (HP:0001697)1.94944802
125Progressive visual loss (HP:0000529)1.94941135
126Diminished motivation (HP:0000745)1.94586238
127Keratitis (HP:0000491)1.93591403
128Abnormality of the lumbar spine (HP:0100712)1.93300904
129Skin ulcer (HP:0200042)1.92764318
130Increased serum ferritin (HP:0003281)1.91757299
131Nausea (HP:0002018)1.91286532
132Thoracic kyphosis (HP:0002942)1.90840475
133Apathy (HP:0000741)1.89691235
134Abnormal platelet volume (HP:0011876)1.89100836
135Abnormality of the pleura (HP:0002103)1.86140094
136Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84089240
137Mutism (HP:0002300)1.80402420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.01564054
2RIPK43.75379463
3TBK13.71171557
4MAP3K143.62417814
5IRAK43.42984442
6TYK23.38710345
7IRAK33.22254507
8ERN13.17543375
9MAP4K13.09135290
10KIT2.58499507
11IKBKE2.54352644
12TNK22.48998851
13CSK2.12977924
14IKBKB2.10354104
15PRPF4B2.02144887
16TAOK11.96559464
17TXK1.92603712
18FGR1.90024908
19CSF1R1.83645513
20FES1.82972117
21JAK11.80038304
22JAK31.71145622
23TGFBR21.66770129
24HCK1.65377400
25EPHB11.62155173
26ZAP701.53226977
27SYK1.50468168
28PBK1.45793321
29BTK1.38413930
30MAP3K131.36856371
31LYN1.35887339
32TRIB31.35550102
33PIM21.28637085
34MATK1.27687720
35NEK91.26708627
36TAOK31.24937666
37JAK21.22915425
38STK101.12051617
39RIPK11.12009696
40RPS6KA41.10168461
41LCK1.08552990
42PKN21.07031167
43NME21.07019234
44CHUK1.06744267
45MAP2K31.06418542
46TEC0.98981104
47CAMK1D0.98375744
48MARK20.97082143
49ABL20.95495110
50BMX0.95122915
51GRK70.94295345
52PRKD20.93747725
53CLK10.88555300
54IRAK10.88468138
55MARK30.85280849
56CDK190.82884503
57IRAK20.80374136
58MAP3K110.80260360
59TESK20.79131502
60PRKCD0.76569857
61PIM10.75974843
62PTK60.74827857
63EGFR0.74715602
64LRRK20.72236764
65MAPK120.70884414
66ABL10.69708297
67MAP3K60.66787100
68PAK40.66299978
69SIK20.66018693
70MAP2K40.65955170
71TTN0.65415118
72CDC42BPA0.64836989
73MAP3K100.64166074
74ITK0.63970636
75MAP3K70.62263128
76MST1R0.62166351
77FGFR40.60981457
78MAP3K30.59641413
79MAPK70.59231429
80PTK2B0.58960027
81STK110.56666302
82DYRK1B0.55464299
83GRK60.55078600
84MAP3K20.54457416
85BMPR20.53790969
86RPS6KA60.52887785
87FGFR30.50837951
88DAPK20.50520617
89KSR20.50161140
90SGK30.49680006
91CAMK1G0.49592109
92MAP3K50.48355528
93TAOK20.47828527
94FYN0.47176695
95TRPM70.46925803
96EIF2AK20.46654023
97PRKG20.44713925
98MAP3K10.44237920
99MAP2K60.43962181
100EPHA30.43185134
101KSR10.42643509
102ALK0.42024563
103MOS0.41624462
104CAMKK20.41512294
105CAMKK10.40800000
106KDR0.40789162
107RPS6KC10.40146990
108RPS6KL10.40146990
109HIPK20.38588671
110YES10.37489311
111STK40.37342759
112MAPKAPK20.36973526
113ARAF0.36675829
114PDPK10.36523685
115ADRBK20.35133068
116RAF10.35113161
117TESK10.34974022
118PDK10.34599198
119SMG10.34465714
120RET0.33126080
121DAPK30.32983442
122SIK10.32742606
123SIK30.31751281
124STK380.30871883
125SCYL20.30616276
126PRKCZ0.30400898
127MAPK40.30352637
128PIK3CG0.30312170
129PRKCQ0.29536658
130SGK20.29427604
131IGF1R0.27222853

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.36276366
2Leishmaniasis_Homo sapiens_hsa051403.72527798
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.88322042
4Osteoclast differentiation_Homo sapiens_hsa043802.63256902
5Pertussis_Homo sapiens_hsa051332.61944041
6Lysosome_Homo sapiens_hsa041422.53168042
7Legionellosis_Homo sapiens_hsa051342.48252122
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.38246722
9Malaria_Homo sapiens_hsa051442.34980276
10Tuberculosis_Homo sapiens_hsa051522.34294781
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.31257488
12Graft-versus-host disease_Homo sapiens_hsa053322.20628910
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.06640250
14Other glycan degradation_Homo sapiens_hsa005112.03708649
15Asthma_Homo sapiens_hsa053101.99491644
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92272701
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.89868956
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88266910
19Measles_Homo sapiens_hsa051621.86125411
20Phagosome_Homo sapiens_hsa041451.84539101
21B cell receptor signaling pathway_Homo sapiens_hsa046621.84055582
22Rheumatoid arthritis_Homo sapiens_hsa053231.84054766
23Allograft rejection_Homo sapiens_hsa053301.82766750
24Salmonella infection_Homo sapiens_hsa051321.80939165
25TNF signaling pathway_Homo sapiens_hsa046681.77231611
26Influenza A_Homo sapiens_hsa051641.74255776
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.72021764
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.60100476
29Toxoplasmosis_Homo sapiens_hsa051451.59244978
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52068183
31Shigellosis_Homo sapiens_hsa051311.45176462
32Antigen processing and presentation_Homo sapiens_hsa046121.44074028
33African trypanosomiasis_Homo sapiens_hsa051431.42427893
34Hematopoietic cell lineage_Homo sapiens_hsa046401.42400758
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.39244361
36Chemokine signaling pathway_Homo sapiens_hsa040621.37833478
37Herpes simplex infection_Homo sapiens_hsa051681.32441464
38Complement and coagulation cascades_Homo sapiens_hsa046101.29253915
39Apoptosis_Homo sapiens_hsa042101.27451471
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19780651
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13623073
42Type I diabetes mellitus_Homo sapiens_hsa049401.12223366
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10730164
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10420174
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09770840
46Hepatitis B_Homo sapiens_hsa051611.08108524
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04364795
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.04091846
49Hepatitis C_Homo sapiens_hsa051601.03648596
50Amoebiasis_Homo sapiens_hsa051461.01846324
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.99129910
52Prion diseases_Homo sapiens_hsa050200.92081954
53Caffeine metabolism_Homo sapiens_hsa002320.87430718
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84513761
55Viral myocarditis_Homo sapiens_hsa054160.84248013
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82494717
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80962850
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77641552
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77149818
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.71329013
61Acute myeloid leukemia_Homo sapiens_hsa052210.69323231
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.67282725
63T cell receptor signaling pathway_Homo sapiens_hsa046600.66845042
64Platelet activation_Homo sapiens_hsa046110.65886098
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.64511979
66Chronic myeloid leukemia_Homo sapiens_hsa052200.62449423
67Pancreatic cancer_Homo sapiens_hsa052120.60499629
68Autoimmune thyroid disease_Homo sapiens_hsa053200.56182320
69Primary immunodeficiency_Homo sapiens_hsa053400.55054236
70Regulation of autophagy_Homo sapiens_hsa041400.54148510
71GnRH signaling pathway_Homo sapiens_hsa049120.53316694
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52865796
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.52212144
74FoxO signaling pathway_Homo sapiens_hsa040680.51083043
75HIF-1 signaling pathway_Homo sapiens_hsa040660.49471550
76Mineral absorption_Homo sapiens_hsa049780.49411831
77Choline metabolism in cancer_Homo sapiens_hsa052310.47550304
78Epstein-Barr virus infection_Homo sapiens_hsa051690.45820013
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44371768
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44260484
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43946284
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43413128
83Type II diabetes mellitus_Homo sapiens_hsa049300.42827473
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42376753
85Endometrial cancer_Homo sapiens_hsa052130.41922408
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.40616177
87VEGF signaling pathway_Homo sapiens_hsa043700.40586688
88Endocytosis_Homo sapiens_hsa041440.40198283
89MAPK signaling pathway_Homo sapiens_hsa040100.39777236
90Rap1 signaling pathway_Homo sapiens_hsa040150.38802823
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38658560
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37802999
93Prolactin signaling pathway_Homo sapiens_hsa049170.36550527
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35476990
95Colorectal cancer_Homo sapiens_hsa052100.35083554
96Insulin resistance_Homo sapiens_hsa049310.33349187
97Collecting duct acid secretion_Homo sapiens_hsa049660.33229546
98Sphingolipid metabolism_Homo sapiens_hsa006000.30525823
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26389599
100Viral carcinogenesis_Homo sapiens_hsa052030.25202536
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24948782
102Proteoglycans in cancer_Homo sapiens_hsa052050.24857481
103Small cell lung cancer_Homo sapiens_hsa052220.24419612
104Notch signaling pathway_Homo sapiens_hsa043300.24339451
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22177869
106Renin-angiotensin system_Homo sapiens_hsa046140.20754803
107Renal cell carcinoma_Homo sapiens_hsa052110.18530511
108Histidine metabolism_Homo sapiens_hsa003400.14455275
109Pentose phosphate pathway_Homo sapiens_hsa000300.14430398
110ABC transporters_Homo sapiens_hsa020100.14170295
111HTLV-I infection_Homo sapiens_hsa051660.12694709
112Steroid biosynthesis_Homo sapiens_hsa001000.09386083
113Non-small cell lung cancer_Homo sapiens_hsa052230.08231608
114Dorso-ventral axis formation_Homo sapiens_hsa043200.08021959
115mTOR signaling pathway_Homo sapiens_hsa041500.06874636

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