LRRC27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.74649761
2motile cilium assembly (GO:0044458)9.70174068
3spermatid development (GO:0007286)9.32463550
4reproduction (GO:0000003)9.25104961
5regulation of cilium movement (GO:0003352)8.71758289
6piRNA metabolic process (GO:0034587)8.68937347
7cilium movement (GO:0003341)8.09047605
8male meiosis (GO:0007140)7.92605679
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.86794627
10synaptonemal complex organization (GO:0070193)7.52652433
11single fertilization (GO:0007338)7.48885596
12synaptonemal complex assembly (GO:0007130)7.30470864
13sperm capacitation (GO:0048240)6.92925822
14nonmotile primary cilium assembly (GO:0035058)6.66548383
15spermatogenesis (GO:0007283)6.41568991
16male gamete generation (GO:0048232)6.39328288
17fertilization (GO:0009566)6.38152912
18microtubule depolymerization (GO:0007019)6.17027653
19negative regulation of inclusion body assembly (GO:0090084)6.16340722
20gamete generation (GO:0007276)5.87482905
21organic cation transport (GO:0015695)5.74430032
22DNA methylation involved in gamete generation (GO:0043046)5.55518599
23behavioral response to nicotine (GO:0035095)5.41286918
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.32909256
25germ cell development (GO:0007281)5.32464341
26male meiosis I (GO:0007141)5.25281602
27chromosome organization involved in meiosis (GO:0070192)5.15984688
28calcium ion-dependent exocytosis (GO:0017156)5.12440769
29ventricular system development (GO:0021591)5.08567943
30regulation of inclusion body assembly (GO:0090083)5.08478502
31regulation of microtubule-based movement (GO:0060632)5.02685954
32left/right axis specification (GO:0070986)4.87640877
33cell recognition (GO:0008037)4.83699303
34seminiferous tubule development (GO:0072520)4.69915600
35multicellular organismal reproductive process (GO:0048609)4.60249988
36microtubule severing (GO:0051013)4.59267641
37meiotic nuclear division (GO:0007126)4.56489069
38substrate-independent telencephalic tangential migration (GO:0021826)4.31329827
39substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.31329827
40left/right pattern formation (GO:0060972)4.29460496
41glycerol ether metabolic process (GO:0006662)4.26784070
42pyrimidine nucleobase catabolic process (GO:0006208)4.23982516
43meiosis I (GO:0007127)4.20523077
44somite development (GO:0061053)4.19669882
45spermatid nucleus differentiation (GO:0007289)4.10786091
46chromosome condensation (GO:0030261)4.06068103
47response to pheromone (GO:0019236)3.99810411
48sequestering of actin monomers (GO:0042989)3.99290992
49DNA packaging (GO:0006323)3.97341232
50meiotic cell cycle (GO:0051321)3.95093713
51ether metabolic process (GO:0018904)3.93216115
52protein localization to cilium (GO:0061512)3.89657661
53protein polyglutamylation (GO:0018095)3.78884482
54monoubiquitinated protein deubiquitination (GO:0035520)3.75448035
55multicellular organismal development (GO:0007275)3.73480155
56intraciliary transport (GO:0042073)3.51308142
57protein K11-linked deubiquitination (GO:0035871)3.47887906
58chaperone-mediated protein complex assembly (GO:0051131)3.45366819
59genitalia morphogenesis (GO:0035112)3.42311922
60axoneme assembly (GO:0035082)3.40580350
61nucleobase catabolic process (GO:0046113)3.39774253
62neuron cell-cell adhesion (GO:0007158)3.37965917
63postsynaptic membrane organization (GO:0001941)3.30087169
64positive regulation of mitochondrial fission (GO:0090141)3.30046390
65regulation of spindle checkpoint (GO:0090231)3.29372435
66smoothened signaling pathway (GO:0007224)3.29329376
67negative regulation of telomere maintenance (GO:0032205)3.28401923
68L-fucose metabolic process (GO:0042354)3.25590993
69L-fucose catabolic process (GO:0042355)3.25590993
70fucose catabolic process (GO:0019317)3.25590993
71single strand break repair (GO:0000012)3.25419610
72photoreceptor cell maintenance (GO:0045494)3.25357019
73cilium organization (GO:0044782)3.22976532
74synapsis (GO:0007129)3.22925514
75neural tube formation (GO:0001841)3.20202907
76retinal cone cell development (GO:0046549)3.16374380
77negative regulation of transcription regulatory region DNA binding (GO:2000678)3.15888652
78microtubule polymerization or depolymerization (GO:0031109)3.13775657
79presynaptic membrane assembly (GO:0097105)3.13232697
80cilium assembly (GO:0042384)3.12617571
81negative regulation of response to food (GO:0032096)3.11020124
82negative regulation of appetite (GO:0032099)3.11020124
83behavioral response to ethanol (GO:0048149)3.08602688
84polyol catabolic process (GO:0046174)3.07977381
85nucleoside diphosphate phosphorylation (GO:0006165)3.06505913
86preassembly of GPI anchor in ER membrane (GO:0016254)3.05863967
87vocalization behavior (GO:0071625)3.04197997
88meiotic cell cycle process (GO:1903046)3.04189860
89cilium morphogenesis (GO:0060271)3.04113143
90protein refolding (GO:0042026)3.03332809
91microtubule bundle formation (GO:0001578)3.02631867
92centriole assembly (GO:0098534)3.00381130
93indolalkylamine metabolic process (GO:0006586)2.99828840
94cellular component assembly involved in morphogenesis (GO:0010927)2.98821152
95synaptic transmission, cholinergic (GO:0007271)2.96965406
96lactate metabolic process (GO:0006089)2.95832380
97alditol metabolic process (GO:0019400)2.94032044
98appendage development (GO:0048736)2.93868995
99limb development (GO:0060173)2.93868995
100interferon-gamma secretion (GO:0072643)2.93861443
101photoreceptor cell development (GO:0042461)2.93173240
102kynurenine metabolic process (GO:0070189)2.92800553
103microtubule-based movement (GO:0007018)2.91859285
104negative regulation of oligodendrocyte differentiation (GO:0048715)2.91812335
105gene silencing by RNA (GO:0031047)2.88203615
106retinal rod cell development (GO:0046548)2.88080746
107presynaptic membrane organization (GO:0097090)2.85889026
108brain morphogenesis (GO:0048854)2.81387319
109glycolytic process (GO:0006096)2.80563002
110GTP biosynthetic process (GO:0006183)2.79569731
111gamma-aminobutyric acid transport (GO:0015812)2.78766685
112cellular ketone body metabolic process (GO:0046950)2.77930803
113nucleus organization (GO:0006997)2.77438752
114indole-containing compound catabolic process (GO:0042436)2.75919566
115indolalkylamine catabolic process (GO:0046218)2.75919566
116tryptophan catabolic process (GO:0006569)2.75919566
117sexual reproduction (GO:0019953)2.75385083
118spinal cord motor neuron differentiation (GO:0021522)2.73203090
119segment specification (GO:0007379)2.72352428
120GPI anchor metabolic process (GO:0006505)2.71823572
121mitotic sister chromatid cohesion (GO:0007064)2.71560526
122mannosylation (GO:0097502)2.69826784
123carnitine transport (GO:0015879)2.69509559
124amino-acid betaine transport (GO:0015838)2.69509559
125positive regulation of sodium ion transmembrane transport (GO:1902307)2.69402619
126limb bud formation (GO:0060174)2.68342967
127synapse assembly (GO:0007416)2.68028776
128platelet dense granule organization (GO:0060155)2.67404488
129centriole replication (GO:0007099)2.63896523
130eye photoreceptor cell development (GO:0042462)2.63216446
131detection of light stimulus involved in visual perception (GO:0050908)2.62958245
132detection of light stimulus involved in sensory perception (GO:0050962)2.62958245
133carnitine transmembrane transport (GO:1902603)2.62686231
134neuronal action potential propagation (GO:0019227)2.59038091
135regulation of collateral sprouting (GO:0048670)2.57565799
136cornea development in camera-type eye (GO:0061303)2.56771188
137glycerol metabolic process (GO:0006071)2.56349264
138regulation of centriole replication (GO:0046599)2.55233899
139negative regulation of astrocyte differentiation (GO:0048712)2.55209663
140retinal ganglion cell axon guidance (GO:0031290)2.53137395
141positive regulation of macrophage activation (GO:0043032)2.53105995
142neuronal action potential (GO:0019228)2.52686419
143ketone body metabolic process (GO:1902224)2.52159608
144cell projection assembly (GO:0030031)2.52029198
145G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51996241
146negative regulation of skeletal muscle tissue development (GO:0048642)2.51446847
147water-soluble vitamin biosynthetic process (GO:0042364)2.50540128
148dendritic spine morphogenesis (GO:0060997)2.50289556
149negative regulation of organelle assembly (GO:1902116)2.46682167
150transmission of nerve impulse (GO:0019226)2.46577656
151regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.46371581
152peptidyl-glutamic acid modification (GO:0018200)2.45094245
153cell differentiation in spinal cord (GO:0021515)2.43943927
154regulation of meiosis I (GO:0060631)2.42582686
155regulation of cilium assembly (GO:1902017)2.40921280
156indole-containing compound metabolic process (GO:0042430)2.40779643
157primary amino compound metabolic process (GO:1901160)2.37496922
158spinal cord development (GO:0021510)2.37108888
159GPI anchor biosynthetic process (GO:0006506)2.36953363
160aldehyde catabolic process (GO:0046185)2.36703072
161fusion of sperm to egg plasma membrane (GO:0007342)13.4590147
162sperm motility (GO:0030317)13.0908817
163acrosome assembly (GO:0001675)11.6030635
164cell wall macromolecule catabolic process (GO:0016998)11.4822570
165cell wall macromolecule metabolic process (GO:0044036)11.4822570
166acrosome reaction (GO:0007340)11.4341037
167sperm-egg recognition (GO:0035036)11.3313880
168multicellular organism reproduction (GO:0032504)11.1073921
169cilium or flagellum-dependent cell motility (GO:0001539)11.0778534
170axonemal dynein complex assembly (GO:0070286)10.3637511
171binding of sperm to zona pellucida (GO:0007339)10.3409265
172plasma membrane fusion (GO:0045026)10.2539807
173cell-cell recognition (GO:0009988)10.1518043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.66539901
2EZH2_22144423_ChIP-Seq_EOC_Human4.11005990
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.72136657
4GBX2_23144817_ChIP-Seq_PC3_Human2.89659341
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75972812
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.46568260
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.38963829
8IGF1R_20145208_ChIP-Seq_DFB_Human2.21870196
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20548736
10TAF15_26573619_Chip-Seq_HEK293_Human2.17127196
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11760281
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09174362
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.04061522
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03815412
15VDR_22108803_ChIP-Seq_LS180_Human2.00400032
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00145356
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.0316440
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85420116
19P300_19829295_ChIP-Seq_ESCs_Human1.84746294
20GATA1_26923725_Chip-Seq_HPCs_Mouse1.82877588
21ZNF274_21170338_ChIP-Seq_K562_Hela1.80799642
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77643118
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.76919606
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.75971586
25STAT1_17558387_ChIP-Seq_HELA_Human1.72677332
26FUS_26573619_Chip-Seq_HEK293_Human1.70648470
27KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.66303422
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66059249
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65292046
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58618226
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.58280064
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56656695
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56557975
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.51430579
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.50294364
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49882320
37PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.49067206
38KAP1_22055183_ChIP-Seq_ESCs_Mouse1.49060444
39GATA3_21867929_ChIP-Seq_CD8_Mouse1.48951375
40FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45833316
41RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45616591
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.45306097
43ER_23166858_ChIP-Seq_MCF-7_Human1.44688803
44IRF1_19129219_ChIP-ChIP_H3396_Human1.44629782
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.43955619
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43559685
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.43522527
48KDM2B_26808549_Chip-Seq_REH_Human1.43070614
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.42860158
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42513498
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41430254
52SMAD4_21799915_ChIP-Seq_A2780_Human1.40724371
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40364946
54* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40284563
55AR_25329375_ChIP-Seq_VCAP_Human1.39966442
56* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.39026807
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38209524
58GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.38180195
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37950630
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.36915119
61MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.35978790
62EWS_26573619_Chip-Seq_HEK293_Human1.35533812
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.35490358
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34695101
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33721441
66STAT3_23295773_ChIP-Seq_U87_Human1.33682045
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33648991
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32848905
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.32057887
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30805341
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30665985
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.29655276
73CBP_20019798_ChIP-Seq_JUKART_Human1.29405636
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29405636
75* DROSHA_22980978_ChIP-Seq_HELA_Human1.28969553
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24255163
77FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23583436
78BCAT_22108803_ChIP-Seq_LS180_Human1.23233230
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.22221237
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22075367
81GATA3_21867929_ChIP-Seq_TH1_Mouse1.21161295
82PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20985486
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.19804062
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18859497
85* RUNX2_22187159_ChIP-Seq_PCA_Human1.18346787
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.17789099
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.17678205
88* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17100102
89LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.16863395
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16367585
91FLI1_21867929_ChIP-Seq_TH2_Mouse1.16286631
92GF1_26923725_Chip-Seq_HPCs_Mouse1.15780120
93TCF4_23295773_ChIP-Seq_U87_Human1.14688484
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14351740
95ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14130767
96* TP53_22573176_ChIP-Seq_HFKS_Human1.13997589
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13820197
98P53_22387025_ChIP-Seq_ESCs_Mouse1.13423815
99NCOR_22424771_ChIP-Seq_293T_Human1.13347754
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13331359
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12609194
102P53_21459846_ChIP-Seq_SAOS-2_Human1.12579016
103SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12320700
104CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11946698
105* RNF2_27304074_Chip-Seq_ESCs_Mouse1.10954836
106OCT4_18555785_Chip-Seq_ESCs_Mouse1.10832200
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10435150
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09905266
109NANOG_19829295_ChIP-Seq_ESCs_Human1.09446262
110SOX2_19829295_ChIP-Seq_ESCs_Human1.09446262
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07659799
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07659799
113RAD21_21589869_ChIP-Seq_MESCs_Mouse1.06983132
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06964495
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05468614
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.05468614
117ERA_21632823_ChIP-Seq_H3396_Human1.05363676
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05310451
119TCF4_22108803_ChIP-Seq_LS180_Human1.05218082
120* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.04951109
121* REST_21632747_ChIP-Seq_MESCs_Mouse1.04774950
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.04378871
123SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04243863
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03720303
125RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03362522
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.03177018
127TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03030551
128CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02957192
129CMYC_18555785_Chip-Seq_ESCs_Mouse1.02541563
130P300_18555785_Chip-Seq_ESCs_Mouse1.02395144
131KLF4_18555785_Chip-Seq_ESCs_Mouse1.02304445
132STAT3_18555785_Chip-Seq_ESCs_Mouse1.02183182
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01902085
134ERG_20517297_ChIP-Seq_VCAP_Human1.00391081
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99598241
136SPI1_26923725_Chip-Seq_HPCs_Mouse0.99117838
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99107539
138CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98989741
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98600699
140SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98338965
141SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98253231
142ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98079875
143P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97936276
144EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97722936
145CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97502671
146PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97213395
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97073823
148* RNF2_27304074_Chip-Seq_NSC_Mouse0.96907930
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96720936
150SMAD3_21741376_ChIP-Seq_ESCs_Human0.96468237
151PU1_27457419_Chip-Seq_LIVER_Mouse0.96061572
152* GATA3_21878914_ChIP-Seq_MCF-7_Human0.95806961
153MYC_18940864_ChIP-ChIP_HL60_Human0.95770520
154GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95403008
155CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95382054
156RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95195838
157IRF8_21731497_ChIP-ChIP_J774_Mouse0.94818590
158SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94729300
159IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94096021
160PRDM14_20953172_ChIP-Seq_ESCs_Human0.94074189
161MYC_19829295_ChIP-Seq_ESCs_Human0.93233825
162LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93224560
163FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93112751
164POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92330010
165CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91783310
166ESET_19884257_ChIP-Seq_ESCs_Mouse0.91584597
167RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91461028
168YY1_22570637_ChIP-Seq_MALME-3M_Human0.90067818
169SOX2_18555785_Chip-Seq_ESCs_Mouse0.88974702
170MYC_27129775_Chip-Seq_CORNEA_Mouse0.88911543
171SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86636093
172E2F1_18555785_Chip-Seq_ESCs_Mouse0.86521623
173GF1B_26923725_Chip-Seq_HPCs_Mouse0.86373405
174RARA_24833708_ChIP-Seq_LIVER_Mouse0.86019031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.85042872
2MP0001929_abnormal_gametogenesis5.37458071
3MP0008877_abnormal_DNA_methylation4.69087773
4MP0002210_abnormal_sex_determination3.56919869
5MP0005670_abnormal_white_adipose3.16295834
6MP0002161_abnormal_fertility/fecundity3.12738475
7MP0003880_abnormal_central_pattern2.96447254
8MP0001145_abnormal_male_reproductive2.92315636
9MP0000653_abnormal_sex_gland2.51978555
10MP0006276_abnormal_autonomic_nervous2.47977541
11MP0002653_abnormal_ependyma_morphology2.35074385
12MP0001968_abnormal_touch/_nociception2.21229636
13MP0006292_abnormal_olfactory_placode2.19108524
14MP0008789_abnormal_olfactory_epithelium2.17370771
15MP0005410_abnormal_fertilization15.6459760
16MP0002160_abnormal_reproductive_system1.95676308
17MP0000778_abnormal_nervous_system1.93622771
18MP0005499_abnormal_olfactory_system1.92680900
19MP0005394_taste/olfaction_phenotype1.92680900
20MP0005645_abnormal_hypothalamus_physiol1.86835586
21MP0001529_abnormal_vocalization1.86083295
22MP0009745_abnormal_behavioral_response1.85100711
23MP0003122_maternal_imprinting1.80239916
24MP0004859_abnormal_synaptic_plasticity1.77607382
25MP0002272_abnormal_nervous_system1.75799522
26MP0001486_abnormal_startle_reflex1.73622428
27MP0001984_abnormal_olfaction1.73499634
28MP0002572_abnormal_emotion/affect_behav1.73278459
29MP0006072_abnormal_retinal_apoptosis1.68670611
30MP0002734_abnormal_mechanical_nocicepti1.63254108
31MP0004142_abnormal_muscle_tone1.60544597
32MP0003635_abnormal_synaptic_transmissio1.59532222
33MP0002064_seizures1.57515162
34MP0002557_abnormal_social/conspecific_i1.56636750
35MP0001485_abnormal_pinna_reflex1.55512352
36MP0002735_abnormal_chemical_nociception1.53168848
37MP0005423_abnormal_somatic_nervous1.51240817
38MP0008058_abnormal_DNA_repair1.46831457
39MP0003646_muscle_fatigue1.45823490
40MP0004885_abnormal_endolymph1.45430186
41MP0002638_abnormal_pupillary_reflex1.42160637
42MP0002063_abnormal_learning/memory/cond1.41531734
43MP0003136_yellow_coat_color1.38894581
44MP0005623_abnormal_meninges_morphology1.37990745
45MP0000569_abnormal_digit_pigmentation1.36070293
46MP0003121_genomic_imprinting1.35643627
47MP0000631_abnormal_neuroendocrine_gland1.35353243
48MP0005084_abnormal_gallbladder_morpholo1.34320046
49MP0000955_abnormal_spinal_cord1.34311983
50MP0004270_analgesia1.33777342
51MP0002184_abnormal_innervation1.32602993
52MP0001970_abnormal_pain_threshold1.32425359
53MP0002067_abnormal_sensory_capabilities1.32047149
54MP0000026_abnormal_inner_ear1.30471475
55MP0008875_abnormal_xenobiotic_pharmacok1.28676174
56MP0002837_dystrophic_cardiac_calcinosis1.27496550
57MP0002822_catalepsy1.26291582
58MP0002752_abnormal_somatic_nervous1.25084859
59MP0001905_abnormal_dopamine_level1.23135711
60MP0010386_abnormal_urinary_bladder1.23006047
61MP0002282_abnormal_trachea_morphology1.20660834
62MP0008995_early_reproductive_senescence1.17327858
63MP0005195_abnormal_posterior_eye1.16870219
64MP0001501_abnormal_sleep_pattern1.13897669
65MP0002882_abnormal_neuron_morphology1.13664644
66MP0009379_abnormal_foot_pigmentation1.13535987
67MP0002909_abnormal_adrenal_gland1.12550848
68MP0002733_abnormal_thermal_nociception1.09288239
69MP0000049_abnormal_middle_ear1.07749015
70MP0000383_abnormal_hair_follicle1.03421177
71MP0002938_white_spotting1.03391995
72MP0005389_reproductive_system_phenotype1.02955680
73MP0002751_abnormal_autonomic_nervous1.01247296
74MP0001963_abnormal_hearing_physiology1.01024185
75MP0004233_abnormal_muscle_weight0.97380532
76MP0010094_abnormal_chromosome_stability0.96457636
77MP0003119_abnormal_digestive_system0.95180248
78MP0005386_behavior/neurological_phenoty0.94688025
79MP0004924_abnormal_behavior0.94688025
80MP0005083_abnormal_biliary_tract0.93754929
81MP0008057_abnormal_DNA_replication0.92799389
82MP0003195_calcinosis0.92508705
83MP0008872_abnormal_physiological_respon0.91693000
84MP0003786_premature_aging0.91284006
85MP0005379_endocrine/exocrine_gland_phen0.89981918
86MP0009046_muscle_twitch0.88696140
87MP0005647_abnormal_sex_gland0.88330999
88MP0002229_neurodegeneration0.87987609
89MP0002152_abnormal_brain_morphology0.87011604
90MP0003137_abnormal_impulse_conducting0.86290977
91MP0008007_abnormal_cellular_replicative0.85941396
92MP0000427_abnormal_hair_cycle0.84473906
93MP0002163_abnormal_gland_morphology0.82974609
94MP0010030_abnormal_orbit_morphology0.82140560
95MP0001188_hyperpigmentation0.81526484
96MP0004043_abnormal_pH_regulation0.79825790
97MP0000647_abnormal_sebaceous_gland0.79789044
98MP0001765_abnormal_ion_homeostasis0.73753910
99MP0005397_hematopoietic_system_phenotyp0.73247036
100MP0001545_abnormal_hematopoietic_system0.73247036
101MP0003011_delayed_dark_adaptation0.72943316
102MP0009278_abnormal_bone_marrow0.72928053
103MP0001324_abnormal_eye_pigmentation0.71799904
104MP0001835_abnormal_antigen_presentation0.68638006
105MP0000015_abnormal_ear_pigmentation0.65056428
106MP0004808_abnormal_hematopoietic_stem0.59252642
107MP0003115_abnormal_respiratory_system0.58188766
108MP0006082_CNS_inflammation0.58138752
109MP0010307_abnormal_tumor_latency0.57492677
110MP0003111_abnormal_nucleus_morphology0.56892382
111MP0001119_abnormal_female_reproductive0.54735860
112MP0001986_abnormal_taste_sensitivity0.54658262
113MP0001764_abnormal_homeostasis0.54037510
114MP0003878_abnormal_ear_physiology0.52811448
115MP0005377_hearing/vestibular/ear_phenot0.52811448
116MP0000358_abnormal_cell_content/0.50935918
117MP0002405_respiratory_system_inflammati0.49962775
118MP0009785_altered_susceptibility_to0.48806063
119MP0004134_abnormal_chest_morphology0.48120266
120MP0002132_abnormal_respiratory_system0.45141460
121MP0002928_abnormal_bile_duct0.44463524
122MP0005253_abnormal_eye_physiology0.43944764
123MP0002234_abnormal_pharynx_morphology0.40949855
124MP0003950_abnormal_plasma_membrane0.40632013
125MP0009115_abnormal_fat_cell0.40334735
126MP0005646_abnormal_pituitary_gland0.40124369
127MP0009697_abnormal_copulation0.39796670
128MP0003699_abnormal_female_reproductive0.39681936
129MP0005551_abnormal_eye_electrophysiolog0.38589862
130MP0002148_abnormal_hypersensitivity_rea0.37915129
131MP0002419_abnormal_innate_immunity0.37348282
132MP0001293_anophthalmia0.36537438
133MP0003436_decreased_susceptibility_to0.36075441
134MP0005257_abnormal_intraocular_pressure0.35254716
135MP0005174_abnormal_tail_pigmentation0.32786197
136MP0005503_abnormal_tendon_morphology0.28986654
137MP0002295_abnormal_pulmonary_circulatio0.28717131
138MP0003448_altered_tumor_morphology0.28398615
139MP0003787_abnormal_imprinting0.28323492
140MP0005391_vision/eye_phenotype0.28160336
141MP0000313_abnormal_cell_death0.28091857
142MP0002723_abnormal_immune_serum0.27213934
143MP0005666_abnormal_adipose_tissue0.27201035
144MP0005636_abnormal_mineral_homeostasis0.26410217
145MP0003948_abnormal_gas_homeostasis0.25858819
146MP0005025_abnormal_response_to0.25184637
147MP0003943_abnormal_hepatobiliary_system0.24677174
148MP0002736_abnormal_nociception_after0.24589986
149MP0003183_abnormal_peptide_metabolism0.24421155
150MP0003942_abnormal_urinary_system0.24378913
151MP0004133_heterotaxia0.24292280
152MP0002102_abnormal_ear_morphology0.23893147
153MP0004811_abnormal_neuron_physiology0.22452055
154MP0002452_abnormal_antigen_presenting0.21642317
155MP0003077_abnormal_cell_cycle0.21105108
156MP0004742_abnormal_vestibular_system0.20931262
157MP0002693_abnormal_pancreas_physiology0.20605459
158MP0003172_abnormal_lysosome_physiology0.20545315
159MP0004036_abnormal_muscle_relaxation0.20098835
160MP0002876_abnormal_thyroid_physiology0.19447488
161MP0005000_abnormal_immune_tolerance0.19167341
162MP0003879_abnormal_hair_cell0.18825586
163MP0003633_abnormal_nervous_system0.18570758
164MP0005464_abnormal_platelet_physiology0.17231005
165MP0001819_abnormal_immune_cell0.17203724
166MP0000534_abnormal_ureter_morphology0.16897973
167MP0002420_abnormal_adaptive_immunity0.16471081
168MP0005388_respiratory_system_phenotype0.16339687
169MP0002133_abnormal_respiratory_system0.16339687
170MP0003279_aneurysm0.16268294
171MP0001502_abnormal_circadian_rhythm0.15484597

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.25670995
2Abnormal respiratory motile cilium morphology (HP:0005938)9.07058404
3Abnormal respiratory epithelium morphology (HP:0012253)9.07058404
4Rhinitis (HP:0012384)7.53863208
5Abnormal ciliary motility (HP:0012262)7.52840870
6Chronic bronchitis (HP:0004469)6.96694947
7Infertility (HP:0000789)6.44691134
8Nasal polyposis (HP:0100582)6.16170617
9Abnormality of the nasal mucosa (HP:0000433)4.99016966
10Pancreatic cysts (HP:0001737)4.50775373
11Bronchiectasis (HP:0002110)4.44924825
12Bronchitis (HP:0012387)4.33846448
13Nephronophthisis (HP:0000090)4.31505975
14Chronic hepatic failure (HP:0100626)3.82975941
15Male infertility (HP:0003251)3.79572532
16Recurrent sinusitis (HP:0011108)3.45329688
17Abnormal spermatogenesis (HP:0008669)3.31816672
18Abnormality of the renal medulla (HP:0100957)3.26902363
19Anencephaly (HP:0002323)3.21770026
20Recurrent otitis media (HP:0000403)3.15877829
21Occipital encephalocele (HP:0002085)3.08724392
22Tubulointerstitial nephritis (HP:0001970)3.04992078
23Abnormal rod and cone electroretinograms (HP:0008323)2.93926994
24Sclerocornea (HP:0000647)2.90992387
25Medial flaring of the eyebrow (HP:0010747)2.89033686
26Hyperventilation (HP:0002883)2.72726736
27Abnormality of midbrain morphology (HP:0002418)2.66259129
28Molar tooth sign on MRI (HP:0002419)2.66259129
29Recurrent bronchitis (HP:0002837)2.58614116
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.56611854
31Attenuation of retinal blood vessels (HP:0007843)2.51495998
32Tubular atrophy (HP:0000092)2.49410184
33Gonadotropin excess (HP:0000837)2.47262205
34Type II lissencephaly (HP:0007260)2.43630135
35Tubulointerstitial abnormality (HP:0001969)2.40641643
36Increased corneal curvature (HP:0100692)2.38835261
37Keratoconus (HP:0000563)2.38835261
38Pendular nystagmus (HP:0012043)2.37663944
39Congenital stationary night blindness (HP:0007642)2.35494448
40Impulsivity (HP:0100710)2.34138854
41Abolished electroretinogram (ERG) (HP:0000550)2.31080958
42Azoospermia (HP:0000027)2.29350866
43Progressive cerebellar ataxia (HP:0002073)2.26364271
44Male pseudohermaphroditism (HP:0000037)2.22598385
45Limb dystonia (HP:0002451)2.22173468
46Postaxial foot polydactyly (HP:0001830)2.20516813
47Bony spicule pigmentary retinopathy (HP:0007737)2.19201363
48Specific learning disability (HP:0001328)2.15517350
49Polyphagia (HP:0002591)2.13764214
50Furrowed tongue (HP:0000221)2.10714977
51Atonic seizures (HP:0010819)2.08772968
52Febrile seizures (HP:0002373)2.07463415
53Fibular hypoplasia (HP:0003038)2.07150683
54Absent speech (HP:0001344)2.04848008
55Lissencephaly (HP:0001339)2.04622565
56Narrow forehead (HP:0000341)2.03584063
57Preaxial hand polydactyly (HP:0001177)2.01972932
58Prominent nasal bridge (HP:0000426)2.00986333
59Absent/shortened dynein arms (HP:0200106)13.1419999
60Dynein arm defect of respiratory motile cilia (HP:0012255)13.1419999
61Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.8559313
62Congenital hepatic fibrosis (HP:0002612)1.99081738
63Aganglionic megacolon (HP:0002251)1.98855726
64Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98291914
65Myokymia (HP:0002411)1.98014470
66Retinitis pigmentosa (HP:0000510)1.95721025
67Severe visual impairment (HP:0001141)1.95539719
68Abnormality of macular pigmentation (HP:0008002)1.93543621
69Multicystic kidney dysplasia (HP:0000003)1.93248502
70Cerebellar dysplasia (HP:0007033)1.91750520
71Dyschromatopsia (HP:0007641)1.91741514
72Thyroid-stimulating hormone excess (HP:0002925)1.87669963
73Broad foot (HP:0001769)1.84175890
74Rib fusion (HP:0000902)1.83766101
75Stage 5 chronic kidney disease (HP:0003774)1.83207258
76Hyperglycinemia (HP:0002154)1.82814147
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.82602862
78Focal motor seizures (HP:0011153)1.81818109
79Absent frontal sinuses (HP:0002688)1.81517584
80Concave nail (HP:0001598)1.81356524
81Congenital primary aphakia (HP:0007707)1.80961039
82Large for gestational age (HP:0001520)1.79076419
83Gait imbalance (HP:0002141)1.78025641
84Abnormality of dentin (HP:0010299)1.77695296
85Polyuria (HP:0000103)1.77380448
86Anophthalmia (HP:0000528)1.76700170
87True hermaphroditism (HP:0010459)1.76200621
88Inability to walk (HP:0002540)1.76127219
89Tubulointerstitial fibrosis (HP:0005576)1.75561334
90Aplasia/Hypoplasia of the tibia (HP:0005772)1.75501158
91Decreased circulating renin level (HP:0003351)1.74494826
92Abnormality of the lower motor neuron (HP:0002366)1.74151419
93Hemiparesis (HP:0001269)1.73637763
94Mitochondrial inheritance (HP:0001427)1.73588299
95Optic nerve hypoplasia (HP:0000609)1.73525320
96Decreased testicular size (HP:0008734)1.73440207
97Retinal dysplasia (HP:0007973)1.72354927
98Abnormality of the renal cortex (HP:0011035)1.71130150
99Oculomotor apraxia (HP:0000657)1.71035101
100Polydipsia (HP:0001959)1.70399256
101Abnormal drinking behavior (HP:0030082)1.70399256
102Decreased central vision (HP:0007663)1.70131233
103J-shaped sella turcica (HP:0002680)1.68851892
104Acute necrotizing encephalopathy (HP:0006965)1.68648910
105Oligodactyly (hands) (HP:0001180)1.68303018
106Left ventricular hypertrophy (HP:0001712)1.67908242
107Asplenia (HP:0001746)1.67697532
108Postaxial hand polydactyly (HP:0001162)1.66971065
109Renal dysplasia (HP:0000110)1.66508783
110Bell-shaped thorax (HP:0001591)1.66296020
111Aplasia/Hypoplasia of the lens (HP:0008063)1.65515995
112Absent epiphyses (HP:0010577)1.64919063
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64919063
114Choroideremia (HP:0001139)1.63918421
115Pancreatic fibrosis (HP:0100732)1.63724183
116Abnormality of permanent molar morphology (HP:0011071)1.63171596
117Abnormality of the dental root (HP:0006486)1.63171596
118Taurodontia (HP:0000679)1.63171596
119Nephrogenic diabetes insipidus (HP:0009806)1.62261627
120Spastic tetraparesis (HP:0001285)1.59838478
121Abnormality of molar morphology (HP:0011070)1.58165063
122Abnormality of molar (HP:0011077)1.58165063
123Short ribs (HP:0000773)1.57497110
124Cystic liver disease (HP:0006706)1.55944784
125Facial cleft (HP:0002006)1.54733149
126Abnormal gallbladder physiology (HP:0012438)1.53440452
127Cholecystitis (HP:0001082)1.53440452
128Abnormality of the anterior horn cell (HP:0006802)1.52412043
129Degeneration of anterior horn cells (HP:0002398)1.52412043
130Impaired proprioception (HP:0010831)1.51326157
131Bile duct proliferation (HP:0001408)1.50321383
132Abnormal biliary tract physiology (HP:0012439)1.50321383
133Deformed sella turcica (HP:0002681)1.49523416
134Retrobulbar optic neuritis (HP:0100654)1.48909858
135Optic neuritis (HP:0100653)1.48909858
136Abnormality of the dental pulp (HP:0006479)1.48707582
137Chronic sinusitis (HP:0011109)1.48351701
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.47777555
139Abnormality of renal excretion (HP:0011036)1.47492294
140Supernumerary spleens (HP:0009799)1.42644824
141Short thorax (HP:0010306)1.42384508
142Nephropathy (HP:0000112)1.40341628
143Asymmetric septal hypertrophy (HP:0001670)1.36966976
144Amyotrophic lateral sclerosis (HP:0007354)1.36642448
145Median cleft lip (HP:0000161)1.36524251
146Poor coordination (HP:0002370)1.35794753
147Short femoral neck (HP:0100864)1.34251592
148Loss of speech (HP:0002371)1.33192280
149Upper motor neuron abnormality (HP:0002127)1.32820186
150Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.32428950
151Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.29155910
152Vaginal atresia (HP:0000148)1.25739417
153Broad distal phalanx of finger (HP:0009836)1.25041247
154Orchitis (HP:0100796)1.25025008
155Genital tract atresia (HP:0001827)1.24906754
156Microglossia (HP:0000171)1.24537352
157Aplasia/Hypoplasia of the fibula (HP:0006492)1.24052277
158Easy fatigability (HP:0003388)1.22596473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.52453470
2PDK48.52453470
3TESK15.94228915
4PDK25.65859719
5PRKD34.62655682
6FRK3.91677049
7ICK3.58659666
8CASK3.50855347
9WNK33.18523920
10MAP4K22.81168949
11MARK12.46123568
12MAP3K42.36507864
13BCKDK2.34483752
14PTK2B2.34152319
15BCR2.01600903
16INSRR1.96063184
17TRIM281.94571450
18WNK41.91653060
19MAPK131.90900494
20EPHB21.76246443
21DYRK21.76161922
22TNIK1.67941329
23NEK21.66370664
24STK381.65792511
25STK391.61945902
26EPHA41.61783575
27PNCK1.59123839
28SIK21.56734445
29CAMKK21.38371449
30EPHA31.32783807
31CSNK1G21.30522516
32DYRK1B1.15654960
33CSNK1G11.11385327
34CSNK1G31.10544524
35NTRK31.01627046
36TLK10.99039488
37PDK10.98181461
38CCNB10.97681544
39PAK30.97513404
40OXSR10.97268146
41NUAK10.95408513
42DAPK20.91794998
43PRKCE0.87054185
44CSNK1A1L0.86632308
45IRAK10.86114696
46RIPK40.83028624
47WNK10.82815619
48DYRK30.81603889
49STK30.81303090
50PASK0.81275221
51CAMK2A0.79897582
52MAPK150.77138237
53ADRBK10.76433452
54MAP2K60.73545253
55CAMK10.73442265
56IRAK20.71023173
57PLK40.70845750
58FGFR20.70814190
59PINK10.67914737
60UHMK10.66524810
61VRK20.65933279
62CDK190.65099948
63CAMK1G0.64946919
64ACVR1B0.64559384
65SGK4940.64024774
66SGK2230.64024774
67TTK0.63841393
68MINK10.62943168
69STK38L0.61832818
70STK110.60037719
71ATR0.58642893
72VRK10.58089977
73PRKACA0.56370851
74CHEK20.56259878
75MST40.54878465
76RPS6KA60.52849532
77TGFBR10.52746765
78SGK20.51966427
79MKNK20.51285952
80BMPR1B0.50397549
81DYRK1A0.48531992
82AKT30.48419280
83TESK20.47273951
84PKN10.46917545
85MAP2K40.46540999
86CAMK40.45270603
87MARK20.45171006
88MAPKAPK30.45168431
89PAK60.45062751
90CDK50.44924277
91PDPK10.44004693
92PHKG10.43905076
93PHKG20.43905076
94CSNK1A10.43266437
95NEK60.43151779
96RPS6KA50.41294828
97TNK20.40932930
98STK160.40700232
99PRKCI0.40684367
100MAP2K20.40188120
101LIMK10.40009397
102CHEK10.39302429
103RPS6KA20.38484966
104YES10.37889684
105CAMK2D0.37785603
106TYRO30.36530133
107CSNK1D0.36472113
108FER0.36160362
109ATM0.35562321
110PRKCA0.34199418
111ZAP700.33504160
112EEF2K0.32924880
113RPS6KB10.31966002
114PAK10.31627681
115MUSK0.30977166
116ROCK10.30627077
117CDC70.27865116
118PRKCG0.27598979
119TXK0.27327762
120BRAF0.25074899
121PAK40.24309865
122MAPKAPK50.24218053
123ZAK0.24131511
124PLK10.24094139
125LMTK20.22065977
126ERBB30.20797693
127BMPR20.20159812
128CAMKK10.19865763
129BRSK20.19791165
130MARK30.19456923
131PIM20.19126070
132PRKAA10.17589065
133MAP3K50.17125458
134WEE10.16646964
135TBK10.15728658
136IRAK40.13892024
137PRKG20.13876801
138PIM10.13367547
139CDK30.12812371
140CLK10.12300580
141MAP2K70.11844152
142NTRK20.11298176
143PRKCD0.10833526
144CSNK2A10.10174003
145MAP3K100.09857360
146PAK20.09298660
147MTOR0.08519976
148PLK20.08348674
149MAP3K140.08162426
150CSF1R0.08046002
151TIE10.07064701
152TEC0.06600454
153PRKCQ0.05235442
154ADRBK20.04879049
155BRSK10.04723616
156PRKG10.04255656
157CDK120.04161021
158BTK0.03681467
159EIF2AK10.03280125
160PRKCZ0.02762274
161RPS6KA10.02659859
162GSK3B0.02010874
163KIT0.01946006
164NEK90.01883027
165CDK10.01096865
166CDK180.00847302
167MAPK80.00385017
168EIF2AK20.00262566
169GRK10.00155425
170PRKACG0.00099818
171TRPM7-0.0122262
172CDK15-0.0002231

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.04479962
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.99127640
3Fatty acid biosynthesis_Homo sapiens_hsa000613.51367918
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.50375342
5Pyruvate metabolism_Homo sapiens_hsa006203.23315816
6Nicotine addiction_Homo sapiens_hsa050333.15845860
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.06873983
8Basal transcription factors_Homo sapiens_hsa030222.88463869
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.77227786
10Phototransduction_Homo sapiens_hsa047442.61815409
11Linoleic acid metabolism_Homo sapiens_hsa005912.59675701
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.56015807
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.53536443
14Glucagon signaling pathway_Homo sapiens_hsa049222.44946444
15Butanoate metabolism_Homo sapiens_hsa006502.44586100
16Propanoate metabolism_Homo sapiens_hsa006402.42616133
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.29077351
18Fanconi anemia pathway_Homo sapiens_hsa034602.26963772
19Oxidative phosphorylation_Homo sapiens_hsa001902.20920768
20Protein export_Homo sapiens_hsa030602.17404163
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08470751
22Primary bile acid biosynthesis_Homo sapiens_hsa001202.02891433
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00108924
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.94110238
25Tryptophan metabolism_Homo sapiens_hsa003801.87131013
26Steroid biosynthesis_Homo sapiens_hsa001001.84355139
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.83405226
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.83372879
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83359092
30Selenocompound metabolism_Homo sapiens_hsa004501.75970586
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.74020786
32Parkinsons disease_Homo sapiens_hsa050121.68209709
33Pentose phosphate pathway_Homo sapiens_hsa000301.67718142
34Glycerolipid metabolism_Homo sapiens_hsa005611.62275706
35Nitrogen metabolism_Homo sapiens_hsa009101.59276978
36Fructose and mannose metabolism_Homo sapiens_hsa000511.56050121
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55712009
38Antigen processing and presentation_Homo sapiens_hsa046121.50582303
39Legionellosis_Homo sapiens_hsa051341.49308011
40GABAergic synapse_Homo sapiens_hsa047271.47603094
41Oocyte meiosis_Homo sapiens_hsa041141.44805941
42Morphine addiction_Homo sapiens_hsa050321.43875608
43Peroxisome_Homo sapiens_hsa041461.43791853
44Dorso-ventral axis formation_Homo sapiens_hsa043201.43767391
45Collecting duct acid secretion_Homo sapiens_hsa049661.42542140
46beta-Alanine metabolism_Homo sapiens_hsa004101.41860425
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40636962
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39005179
49PPAR signaling pathway_Homo sapiens_hsa033201.38721424
50Amphetamine addiction_Homo sapiens_hsa050311.38382407
51Glycerophospholipid metabolism_Homo sapiens_hsa005641.35631739
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35560056
53Glutamatergic synapse_Homo sapiens_hsa047241.29760166
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.28165154
55Purine metabolism_Homo sapiens_hsa002301.26177773
56Circadian entrainment_Homo sapiens_hsa047131.25918831
57Ether lipid metabolism_Homo sapiens_hsa005651.25828379
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19810505
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.19799794
60Huntingtons disease_Homo sapiens_hsa050161.19503390
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.17679564
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13624378
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.12625345
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10372583
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10287603
66Mineral absorption_Homo sapiens_hsa049781.09263133
67Arachidonic acid metabolism_Homo sapiens_hsa005901.09217949
68Caffeine metabolism_Homo sapiens_hsa002321.08278904
69Histidine metabolism_Homo sapiens_hsa003401.07280503
70mRNA surveillance pathway_Homo sapiens_hsa030151.07176529
71Alzheimers disease_Homo sapiens_hsa050101.05810754
72Serotonergic synapse_Homo sapiens_hsa047261.03057526
73Renin secretion_Homo sapiens_hsa049240.98773052
74RNA polymerase_Homo sapiens_hsa030200.98098993
75Cocaine addiction_Homo sapiens_hsa050300.97652088
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96747731
77RNA transport_Homo sapiens_hsa030130.90401544
78Phenylalanine metabolism_Homo sapiens_hsa003600.90182008
79Dopaminergic synapse_Homo sapiens_hsa047280.89905898
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89162740
81Rheumatoid arthritis_Homo sapiens_hsa053230.86835470
82Retinol metabolism_Homo sapiens_hsa008300.86188080
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.84928675
84Carbon metabolism_Homo sapiens_hsa012000.84278046
85Synaptic vesicle cycle_Homo sapiens_hsa047210.82805129
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80676186
87Axon guidance_Homo sapiens_hsa043600.79312266
88Cardiac muscle contraction_Homo sapiens_hsa042600.75835313
89Tyrosine metabolism_Homo sapiens_hsa003500.74666218
90Salivary secretion_Homo sapiens_hsa049700.74155065
91Sulfur relay system_Homo sapiens_hsa041220.73814199
92Phagosome_Homo sapiens_hsa041450.72758089
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68006227
94Allograft rejection_Homo sapiens_hsa053300.67615608
95Glutathione metabolism_Homo sapiens_hsa004800.67061509
96Basal cell carcinoma_Homo sapiens_hsa052170.66960367
97Regulation of autophagy_Homo sapiens_hsa041400.66379894
98Measles_Homo sapiens_hsa051620.66119284
99Influenza A_Homo sapiens_hsa051640.65473864
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63539553
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63476466
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62857377
103Salmonella infection_Homo sapiens_hsa051320.62078647
104Graft-versus-host disease_Homo sapiens_hsa053320.61823061
105Cholinergic synapse_Homo sapiens_hsa047250.60729112
106Fat digestion and absorption_Homo sapiens_hsa049750.59041096
107Fatty acid metabolism_Homo sapiens_hsa012120.58578855
108Other glycan degradation_Homo sapiens_hsa005110.56493774
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54381198
110cAMP signaling pathway_Homo sapiens_hsa040240.53789367
111Olfactory transduction_Homo sapiens_hsa047400.53113003
112Inositol phosphate metabolism_Homo sapiens_hsa005620.52993890
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.51928859
114Ribosome_Homo sapiens_hsa030100.50999520
115Sphingolipid metabolism_Homo sapiens_hsa006000.50883482
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50160850
117Pyrimidine metabolism_Homo sapiens_hsa002400.50082113
118Fatty acid elongation_Homo sapiens_hsa000620.48689185
119Long-term potentiation_Homo sapiens_hsa047200.48321550
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47445390
121N-Glycan biosynthesis_Homo sapiens_hsa005100.46863975
122Endocytosis_Homo sapiens_hsa041440.45962794
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45522194
124B cell receptor signaling pathway_Homo sapiens_hsa046620.45349283
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45180307
126Systemic lupus erythematosus_Homo sapiens_hsa053220.45056471
127Estrogen signaling pathway_Homo sapiens_hsa049150.44307195
128Insulin secretion_Homo sapiens_hsa049110.44151032
129One carbon pool by folate_Homo sapiens_hsa006700.43843778
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43825480
131Calcium signaling pathway_Homo sapiens_hsa040200.43148240
132Hedgehog signaling pathway_Homo sapiens_hsa043400.43147516
133Toxoplasmosis_Homo sapiens_hsa051450.42826590
134ABC transporters_Homo sapiens_hsa020100.42171699
135Gastric acid secretion_Homo sapiens_hsa049710.41456233
136Ovarian steroidogenesis_Homo sapiens_hsa049130.41204781
137Homologous recombination_Homo sapiens_hsa034400.41007205
138Fatty acid degradation_Homo sapiens_hsa000710.40106957
139Renin-angiotensin system_Homo sapiens_hsa046140.39366766
140Malaria_Homo sapiens_hsa051440.38773247
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37901688
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.37779833
143Osteoclast differentiation_Homo sapiens_hsa043800.37383362
144Oxytocin signaling pathway_Homo sapiens_hsa049210.36712467
145RNA degradation_Homo sapiens_hsa030180.34508760
146VEGF signaling pathway_Homo sapiens_hsa043700.33478085
147Hippo signaling pathway_Homo sapiens_hsa043900.33470060
148Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33234828
149Taste transduction_Homo sapiens_hsa047420.32880169
150Base excision repair_Homo sapiens_hsa034100.32733716
151Chemical carcinogenesis_Homo sapiens_hsa052040.31312178
152Circadian rhythm_Homo sapiens_hsa047100.30950616
153Autoimmune thyroid disease_Homo sapiens_hsa053200.30380016
154Herpes simplex infection_Homo sapiens_hsa051680.30094086
155Epstein-Barr virus infection_Homo sapiens_hsa051690.30089473
156SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29678059
157Thyroid hormone synthesis_Homo sapiens_hsa049180.29364536
158Arginine and proline metabolism_Homo sapiens_hsa003300.29346087
159HIF-1 signaling pathway_Homo sapiens_hsa040660.27814769
160Type I diabetes mellitus_Homo sapiens_hsa049400.26608014
161Metabolic pathways_Homo sapiens_hsa011000.24869513
162Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24432256
163Tuberculosis_Homo sapiens_hsa051520.23354691

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