LRRC28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)5.74350396
2cytidine metabolic process (GO:0046087)5.74350396
3cytidine catabolic process (GO:0006216)5.74350396
4piRNA metabolic process (GO:0034587)5.69776939
5sperm motility (GO:0030317)5.24079729
6glycerophospholipid catabolic process (GO:0046475)5.15500889
7pyrimidine ribonucleoside catabolic process (GO:0046133)5.08178340
8DNA deamination (GO:0045006)5.02615713
9multicellular organism reproduction (GO:0032504)4.95200365
10L-phenylalanine catabolic process (GO:0006559)4.71165098
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.71165098
12fusion of sperm to egg plasma membrane (GO:0007342)4.70822613
13fatty acid elongation (GO:0030497)4.67861971
14acrosome reaction (GO:0007340)4.66304056
15behavioral response to nicotine (GO:0035095)4.59100330
16male meiosis (GO:0007140)4.53816545
17central nervous system myelination (GO:0022010)4.24005125
18axon ensheathment in central nervous system (GO:0032291)4.24005125
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.23853889
20L-phenylalanine metabolic process (GO:0006558)4.23853889
21sperm-egg recognition (GO:0035036)4.13017670
22epithelial cilium movement (GO:0003351)4.03356870
23L-fucose catabolic process (GO:0042355)4.00349392
24fucose catabolic process (GO:0019317)4.00349392
25L-fucose metabolic process (GO:0042354)4.00349392
26motile cilium assembly (GO:0044458)3.96379920
27aromatic amino acid family catabolic process (GO:0009074)3.95208976
28binding of sperm to zona pellucida (GO:0007339)3.95101801
29DNA methylation involved in gamete generation (GO:0043046)3.94689979
30microtubule depolymerization (GO:0007019)3.92832754
31reproduction (GO:0000003)3.90214228
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.79940806
33axonemal dynein complex assembly (GO:0070286)3.77328108
34platelet dense granule organization (GO:0060155)3.76002447
35microtubule severing (GO:0051013)3.74797255
36regulation of cilium movement (GO:0003352)3.71662431
37microtubule polymerization or depolymerization (GO:0031109)3.70841671
38eosinophil chemotaxis (GO:0048245)3.70813344
39single fertilization (GO:0007338)3.66638634
40negative regulation by host of viral transcription (GO:0043922)3.60674233
41cell-cell recognition (GO:0009988)3.57420191
42spermatid development (GO:0007286)3.56924482
43long-chain fatty acid biosynthetic process (GO:0042759)3.56798419
44preassembly of GPI anchor in ER membrane (GO:0016254)3.56452206
45regulation of meiosis I (GO:0060631)3.52967310
46cell wall macromolecule catabolic process (GO:0016998)3.46501397
47cell wall macromolecule metabolic process (GO:0044036)3.46501397
48synaptonemal complex organization (GO:0070193)3.45740262
49plasma membrane fusion (GO:0045026)3.41800682
50activated T cell proliferation (GO:0050798)3.40229927
51cholesterol biosynthetic process (GO:0006695)3.38353686
52response to pheromone (GO:0019236)3.35200812
53eosinophil migration (GO:0072677)3.34032063
54fertilization (GO:0009566)3.33208739
55synaptonemal complex assembly (GO:0007130)3.32451395
56indolalkylamine metabolic process (GO:0006586)3.29444057
57male meiosis I (GO:0007141)3.28937337
58peptidyl-glutamic acid modification (GO:0018200)3.26548317
59neural tube formation (GO:0001841)3.26447667
60bile acid biosynthetic process (GO:0006699)3.24627958
61kynurenine metabolic process (GO:0070189)3.21366236
62heme transport (GO:0015886)3.21338637
63meiotic cell cycle (GO:0051321)3.18529570
64indolalkylamine catabolic process (GO:0046218)3.17916734
65tryptophan catabolic process (GO:0006569)3.17916734
66indole-containing compound catabolic process (GO:0042436)3.17916734
67glutathione derivative metabolic process (GO:1901685)3.17630855
68glutathione derivative biosynthetic process (GO:1901687)3.17630855
69regulation of chronic inflammatory response (GO:0002676)3.16570329
70protein complex biogenesis (GO:0070271)3.16532197
71pyrimidine nucleobase catabolic process (GO:0006208)3.16023003
72organic cation transport (GO:0015695)3.15051123
73acrosome assembly (GO:0001675)3.14245148
74behavioral response to ethanol (GO:0048149)3.13764132
75cilium movement (GO:0003341)3.11462753
76male gamete generation (GO:0048232)3.11020978
77spermatogenesis (GO:0007283)3.10784143
78DNA demethylation (GO:0080111)3.10706415
79cilium or flagellum-dependent cell motility (GO:0001539)3.09619184
80female gonad development (GO:0008585)3.08094711
81sperm capacitation (GO:0048240)3.07697269
82gamete generation (GO:0007276)3.06818844
83tryptophan metabolic process (GO:0006568)3.02601519
84mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.00924870
85mitochondrial respiratory chain complex I assembly (GO:0032981)3.00924870
86NADH dehydrogenase complex assembly (GO:0010257)3.00924870
87sterol biosynthetic process (GO:0016126)3.00613228
88pyrimidine nucleoside catabolic process (GO:0046135)3.00066857
89adaptation of signaling pathway (GO:0023058)2.99767626
90coenzyme catabolic process (GO:0009109)2.98580018
91glyoxylate metabolic process (GO:0046487)2.98375199
92urea metabolic process (GO:0019627)2.97835570
93urea cycle (GO:0000050)2.97835570
94negative regulation of mast cell activation (GO:0033004)2.96533011
95mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95603579
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93922019
97protein localization to cilium (GO:0061512)2.93560569
98negative regulation of telomere maintenance (GO:0032205)2.93548845
99L-serine metabolic process (GO:0006563)2.92183090
100gamma-aminobutyric acid transport (GO:0015812)2.92144158
101very long-chain fatty acid metabolic process (GO:0000038)2.91845075
102protein polyglutamylation (GO:0018095)2.91209047
103regulation of activation of Janus kinase activity (GO:0010533)2.90210504
104cornea development in camera-type eye (GO:0061303)2.89598476
105pyrimidine-containing compound catabolic process (GO:0072529)2.88700336
106isoprenoid biosynthetic process (GO:0008299)2.88052616
107peroxisome fission (GO:0016559)2.87903997
108GPI anchor metabolic process (GO:0006505)2.87114318
109positive regulation of mitochondrial fission (GO:0090141)2.86513821
110bile acid metabolic process (GO:0008206)2.86080890
111dopamine transport (GO:0015872)2.82871300
112cofactor catabolic process (GO:0051187)2.81714580
113serine family amino acid biosynthetic process (GO:0009070)2.81632587
114cellular biogenic amine catabolic process (GO:0042402)2.80281582
115amine catabolic process (GO:0009310)2.80281582
116cellular ketone body metabolic process (GO:0046950)2.79584110
117detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.78591992
118regulation of cholesterol esterification (GO:0010872)2.77890888
119regulation of regulatory T cell differentiation (GO:0045589)2.77887966
120mitochondrial respiratory chain complex assembly (GO:0033108)2.77598659
121fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.76618549
122negative regulation of inclusion body assembly (GO:0090084)2.75903924
123somite development (GO:0061053)2.75845865
124maturation of 5.8S rRNA (GO:0000460)2.74613189
125pyrimidine-containing compound transmembrane transport (GO:0072531)2.74012303
126nucleobase catabolic process (GO:0046113)2.73709133
127high-density lipoprotein particle remodeling (GO:0034375)2.73106876
128regulation of acrosome reaction (GO:0060046)2.72875601
129aromatic amino acid family metabolic process (GO:0009072)2.72856776
130nucleotide transmembrane transport (GO:1901679)2.71873749
131amino acid salvage (GO:0043102)2.71796082
132L-methionine salvage (GO:0071267)2.71796082
133L-methionine biosynthetic process (GO:0071265)2.71796082
134water-soluble vitamin biosynthetic process (GO:0042364)2.71463489
135polyol transport (GO:0015791)2.71373932
136negative regulation of transcription regulatory region DNA binding (GO:2000678)2.71104862
137meiosis I (GO:0007127)2.71052979
138sulfur amino acid catabolic process (GO:0000098)2.70665260
139chaperone-mediated protein transport (GO:0072321)2.70024928
140mannosylation (GO:0097502)2.69322035
141serine family amino acid catabolic process (GO:0009071)2.69216345
142positive regulation of defense response to virus by host (GO:0002230)2.69020539
143cellular response to gamma radiation (GO:0071480)2.68384788
144S-adenosylmethionine metabolic process (GO:0046500)2.67799020
145regulation of hexokinase activity (GO:1903299)2.67336429
146regulation of glucokinase activity (GO:0033131)2.67336429
147indole-containing compound metabolic process (GO:0042430)2.67052896
148nitrogen cycle metabolic process (GO:0071941)2.65706743
149protein neddylation (GO:0045116)2.65553574
150protein K11-linked deubiquitination (GO:0035871)2.65166765
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64833352
152cysteine metabolic process (GO:0006534)2.63184000
153tyrosine metabolic process (GO:0006570)2.62694383
154negative regulation of B cell proliferation (GO:0030889)2.60490700
155neuronal action potential (GO:0019228)2.59539994
156cilium morphogenesis (GO:0060271)2.59416483
157positive regulation of calcium-mediated signaling (GO:0050850)2.59134912
158establishment of protein localization to mitochondrial membrane (GO:0090151)2.57512405
159regulation of chemokine-mediated signaling pathway (GO:0070099)2.53830678
160positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.53617391
161spinal cord motor neuron differentiation (GO:0021522)2.51928419
162DNA double-strand break processing (GO:0000729)2.50238694
163monocyte chemotaxis (GO:0002548)2.49508375
164ketone body metabolic process (GO:1902224)2.49041487
165positive regulation of T cell chemotaxis (GO:0010820)2.48631213
166regulation of T cell chemotaxis (GO:0010819)2.48631213
167GPI anchor biosynthetic process (GO:0006506)2.47576551
168negative regulation of T cell differentiation in thymus (GO:0033085)2.46059027
169sulfation (GO:0051923)2.45749575
170drug catabolic process (GO:0042737)2.45190192
171regulation of mononuclear cell migration (GO:0071675)2.44641302
172exogenous drug catabolic process (GO:0042738)2.44634236
173negative regulation of heart rate (GO:0010459)2.43564028
174energy coupled proton transport, down electrochemical gradient (GO:0015985)2.42875293
175ATP synthesis coupled proton transport (GO:0015986)2.42875293
176ubiquinone biosynthetic process (GO:0006744)2.38548063
177somite rostral/caudal axis specification (GO:0032525)2.36910241
178synaptic transmission, cholinergic (GO:0007271)2.36546410
179ubiquinone metabolic process (GO:0006743)2.35960319
180primary amino compound metabolic process (GO:1901160)2.35813152
181axoneme assembly (GO:0035082)2.35313569
182macrophage chemotaxis (GO:0048246)2.34631938
183positive regulation of natural killer cell mediated immunity (GO:0002717)2.33215057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.79776927
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.73541410
3EZH2_22144423_ChIP-Seq_EOC_Human3.17352781
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.08795142
5GBX2_23144817_ChIP-Seq_PC3_Human2.82771592
6TAF15_26573619_Chip-Seq_HEK293_Human2.59610682
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.55452665
8VDR_22108803_ChIP-Seq_LS180_Human2.45850562
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44230087
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37708531
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.25416272
12KAP1_22055183_ChIP-Seq_ESCs_Mouse2.18470220
13IGF1R_20145208_ChIP-Seq_DFB_Human2.17970195
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10849851
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.08790286
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.01222128
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94492065
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91535787
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89200362
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86976412
21EWS_26573619_Chip-Seq_HEK293_Human1.84177505
22SUZ12_27294783_Chip-Seq_NPCs_Mouse1.82916794
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75186237
24RNF2_27304074_Chip-Seq_NSC_Mouse1.75154994
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.73100805
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72230835
27* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71123931
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70356396
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68784799
30NANOG_18555785_Chip-Seq_ESCs_Mouse1.66112284
31TAL1_26923725_Chip-Seq_HPCs_Mouse1.64579630
32FUS_26573619_Chip-Seq_HEK293_Human1.60932039
33BCAT_22108803_ChIP-Seq_LS180_Human1.60773058
34RXR_22158963_ChIP-Seq_LIVER_Mouse1.60666715
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59876243
36IRF1_19129219_ChIP-ChIP_H3396_Human1.57999000
37SUZ12_18555785_Chip-Seq_ESCs_Mouse1.57935246
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57724254
39TP53_22573176_ChIP-Seq_HFKS_Human1.57332594
40EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.55836508
41* AR_25329375_ChIP-Seq_VCAP_Human1.54976750
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.54724416
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53356340
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52776441
45* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52084245
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51201460
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.50861660
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50485441
49P53_22387025_ChIP-Seq_ESCs_Mouse1.49138701
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.48347697
51STAT3_18555785_Chip-Seq_ESCs_Mouse1.46349991
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46152084
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.46062168
54OCT4_18555785_Chip-Seq_ESCs_Mouse1.43365926
55LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43168834
56P300_18555785_Chip-Seq_ESCs_Mouse1.42964629
57* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41827531
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.40429628
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39387835
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.38410387
61ER_23166858_ChIP-Seq_MCF-7_Human1.38321389
62HTT_18923047_ChIP-ChIP_STHdh_Human1.37733688
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37455349
64RUNX1_27457419_Chip-Seq_LIVER_Mouse1.36710853
65REST_21632747_ChIP-Seq_MESCs_Mouse1.36698656
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36636836
67P300_19829295_ChIP-Seq_ESCs_Human1.36577650
68KLF4_18555785_Chip-Seq_ESCs_Mouse1.36425941
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.36081603
70IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35894897
71CBP_20019798_ChIP-Seq_JUKART_Human1.35894897
72NMYC_18555785_Chip-Seq_ESCs_Mouse1.35753855
73SOX2_18555785_Chip-Seq_ESCs_Mouse1.35524735
74KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34253472
75KDM2B_26808549_Chip-Seq_REH_Human1.34019354
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.33603012
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.33441930
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33329474
79* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32587648
80STAT1_17558387_ChIP-Seq_HELA_Human1.32436397
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31829133
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.31189036
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.30845663
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30845663
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30565270
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30558883
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.28622442
88* GATA3_21878914_ChIP-Seq_MCF-7_Human1.28349132
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28111015
90BP1_19119308_ChIP-ChIP_Hs578T_Human1.26941459
91MYC_18940864_ChIP-ChIP_HL60_Human1.26876731
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26871696
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26101957
94TCF4_22108803_ChIP-Seq_LS180_Human1.26043110
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.25603800
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25058983
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.22908519
98AR_20517297_ChIP-Seq_VCAP_Human1.22455388
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21858849
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21815774
101SMAD1_18555785_Chip-Seq_ESCs_Mouse1.20816815
102CTCF_18555785_Chip-Seq_ESCs_Mouse1.20458301
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20414136
104ZFX_18555785_Chip-Seq_ESCs_Mouse1.20189563
105ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19739346
106ESRRB_18555785_Chip-Seq_ESCs_Mouse1.19315246
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18384751
108SMAD4_21799915_ChIP-Seq_A2780_Human1.17391413
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16826870
110PU1_27457419_Chip-Seq_LIVER_Mouse1.15380025
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15291492
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15291492
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15169414
114* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14838945
115NCOR_22424771_ChIP-Seq_293T_Human1.13052702
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12882309
117CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12750809
118OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12079092
119STAT3_23295773_ChIP-Seq_U87_Human1.11186804
120TCF4_23295773_ChIP-Seq_U87_Human1.11126597
121TBL1_22424771_ChIP-Seq_293T_Human1.11087321
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11080734
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10995465
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.09933756
125* RUNX2_22187159_ChIP-Seq_PCA_Human1.09627911
126PIAS1_25552417_ChIP-Seq_VCAP_Human1.08853894
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08629734
128NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08445539
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07947248
130* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06801554
131TP53_16413492_ChIP-PET_HCT116_Human1.06502191
132SMAD3_21741376_ChIP-Seq_EPCs_Human1.06047234
133PHF8_20622853_ChIP-Seq_HELA_Human1.05730028
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05553164
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.05212682
136RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05198197
137SOX2_19829295_ChIP-Seq_ESCs_Human1.05025617
138NANOG_19829295_ChIP-Seq_ESCs_Human1.05025617
139SALL1_21062744_ChIP-ChIP_HESCs_Human1.04813767
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04307551
141PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03809860
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03326354
143SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02794152
144MYC_19829295_ChIP-Seq_ESCs_Human1.00421095
145CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00358529
146CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99850170
147HOXB7_26014856_ChIP-Seq_BT474_Human0.99026066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.26736509
2MP0002139_abnormal_hepatobiliary_system4.53055149
3MP0005451_abnormal_body_composition3.82785800
4MP0005360_urolithiasis3.63061813
5MP0003806_abnormal_nucleotide_metabolis3.36849141
6MP0003718_maternal_effect3.27936419
7MP0008875_abnormal_xenobiotic_pharmacok3.25571624
8MP0005085_abnormal_gallbladder_physiolo3.04037190
9MP0005671_abnormal_response_to2.84369287
10MP0000566_synostosis2.80555520
11MP0005365_abnormal_bile_salt2.72283605
12MP0008877_abnormal_DNA_methylation2.56682344
13MP0002638_abnormal_pupillary_reflex2.55756703
14MP0001929_abnormal_gametogenesis2.40873693
15MP0000569_abnormal_digit_pigmentation2.38868639
16MP0005408_hypopigmentation2.33003984
17MP0003698_abnormal_male_reproductive2.31455280
18MP0009046_muscle_twitch2.12810826
19MP0009697_abnormal_copulation2.03817878
20MP0002102_abnormal_ear_morphology2.03619449
21MP0001984_abnormal_olfaction1.97297194
22MP0004145_abnormal_muscle_electrophysio1.94211152
23MP0005646_abnormal_pituitary_gland1.94052949
24MP0003950_abnormal_plasma_membrane1.91925886
25MP0001529_abnormal_vocalization1.90939483
26MP0006292_abnormal_olfactory_placode1.84850336
27MP0009745_abnormal_behavioral_response1.82605093
28MP0001968_abnormal_touch/_nociception1.81173630
29MP0003136_yellow_coat_color1.80656406
30MP0002210_abnormal_sex_determination1.74746233
31MP0003186_abnormal_redox_activity1.70660217
32MP0008789_abnormal_olfactory_epithelium1.66759442
33MP0005647_abnormal_sex_gland1.65856273
34MP0001905_abnormal_dopamine_level1.65057589
35MP0002736_abnormal_nociception_after1.60387839
36MP0002161_abnormal_fertility/fecundity1.57230310
37MP0000653_abnormal_sex_gland1.56003591
38MP0002653_abnormal_ependyma_morphology1.54799448
39MP0001873_stomach_inflammation1.51250973
40MP0004885_abnormal_endolymph1.50284178
41MP0005253_abnormal_eye_physiology1.47198859
42MP0005084_abnormal_gallbladder_morpholo1.46407890
43MP0005670_abnormal_white_adipose1.45414723
44MP0008872_abnormal_physiological_respon1.45298812
45MP0002837_dystrophic_cardiac_calcinosis1.44492380
46MP0002160_abnormal_reproductive_system1.38316237
47MP0006072_abnormal_retinal_apoptosis1.37611677
48MP0002938_white_spotting1.37365294
49MP0005499_abnormal_olfactory_system1.36939380
50MP0005394_taste/olfaction_phenotype1.36939380
51MP0001501_abnormal_sleep_pattern1.36922794
52MP0003252_abnormal_bile_duct1.36639871
53MP0002064_seizures1.35937725
54MP0001145_abnormal_male_reproductive1.33190655
55MP0003699_abnormal_female_reproductive1.32488616
56MP0000579_abnormal_nail_morphology1.32366951
57MP0002277_abnormal_respiratory_mucosa1.32069274
58MP0002735_abnormal_chemical_nociception1.31136014
59MP0004270_analgesia1.30737251
60MP0003646_muscle_fatigue1.30602542
61MP0003787_abnormal_imprinting1.30421531
62MP0003195_calcinosis1.29868842
63MP0005395_other_phenotype1.28644409
64MP0002067_abnormal_sensory_capabilities1.28273000
65MP0000920_abnormal_myelination1.28234206
66MP0002163_abnormal_gland_morphology1.26203322
67MP0002234_abnormal_pharynx_morphology1.23476293
68MP0004924_abnormal_behavior1.23408244
69MP0005386_behavior/neurological_phenoty1.23408244
70MP0001346_abnormal_lacrimal_gland1.22280230
71MP0001764_abnormal_homeostasis1.22262247
72MP0004381_abnormal_hair_follicle1.21686557
73MP0002572_abnormal_emotion/affect_behav1.21376425
74MP0004782_abnormal_surfactant_physiolog1.21299175
75MP0005332_abnormal_amino_acid1.20958528
76MP0001970_abnormal_pain_threshold1.19376285
77MP0001119_abnormal_female_reproductive1.19103353
78MP0002733_abnormal_thermal_nociception1.19044103
79MP0010329_abnormal_lipoprotein_level1.17425128
80MP0003329_amyloid_beta_deposits1.14556886
81MP0003880_abnormal_central_pattern1.14313669
82MP0002876_abnormal_thyroid_physiology1.14310657
83MP0004043_abnormal_pH_regulation1.12348873
84MP0002928_abnormal_bile_duct1.10061328
85MP0005174_abnormal_tail_pigmentation1.07209902
86MP0004142_abnormal_muscle_tone1.07111436
87MP0006082_CNS_inflammation1.06114357
88MP0002796_impaired_skin_barrier1.02806358
89MP0008058_abnormal_DNA_repair1.02220666
90MP0006276_abnormal_autonomic_nervous1.01821940
91MP0003137_abnormal_impulse_conducting1.00357295
92MP0002063_abnormal_learning/memory/cond0.99453007
93MP0005389_reproductive_system_phenotype0.99017134
94MP0002751_abnormal_autonomic_nervous0.96390155
95MP0005379_endocrine/exocrine_gland_phen0.94152155
96MP0002557_abnormal_social/conspecific_i0.93822554
97MP0003011_delayed_dark_adaptation0.93361361
98MP0005645_abnormal_hypothalamus_physiol0.93314065
99MP0002132_abnormal_respiratory_system0.92337830
100MP0010094_abnormal_chromosome_stability0.92120924
101MP0003937_abnormal_limbs/digits/tail_de0.91184352
102MP0000778_abnormal_nervous_system0.90748439
103MP0009764_decreased_sensitivity_to0.90454037
104MP0001502_abnormal_circadian_rhythm0.89509831
105MP0005195_abnormal_posterior_eye0.88023040
106MP0003635_abnormal_synaptic_transmissio0.86898310
107MP0003183_abnormal_peptide_metabolism0.86784874
108MP0002095_abnormal_skin_pigmentation0.86671397
109MP0002734_abnormal_mechanical_nocicepti0.86344182
110MP0004019_abnormal_vitamin_homeostasis0.86224508
111MP0001485_abnormal_pinna_reflex0.85637804
112MP0002138_abnormal_hepatobiliary_system0.85405896
113MP0003119_abnormal_digestive_system0.84610783
114MP0000372_irregular_coat_pigmentation0.83896715
115MP0000427_abnormal_hair_cycle0.83802159
116MP0002909_abnormal_adrenal_gland0.83602228
117MP0002118_abnormal_lipid_homeostasis0.83160169
118MP0009765_abnormal_xenobiotic_induced0.82353797
119MP0001177_atelectasis0.82035673
120MP0000383_abnormal_hair_follicle0.81432824
121MP0003656_abnormal_erythrocyte_physiolo0.80955379
122MP0004147_increased_porphyrin_level0.80406396
123MP0002249_abnormal_larynx_morphology0.80221661
124MP0004215_abnormal_myocardial_fiber0.77399609
125MP0003938_abnormal_ear_development0.76221000
126MP0001440_abnormal_grooming_behavior0.75443176
127MP0000647_abnormal_sebaceous_gland0.75319433
128MP0004742_abnormal_vestibular_system0.75296511
129MP0009785_altered_susceptibility_to0.75038694
130MP0002233_abnormal_nose_morphology0.75001152
131MP0001188_hyperpigmentation0.74820623
132MP0002229_neurodegeneration0.73230958
133MP0001986_abnormal_taste_sensitivity0.73150326
134MP0008260_abnormal_autophagy0.71766489
135MP0004133_heterotaxia0.70784847
136MP0001963_abnormal_hearing_physiology0.70735575
137MP0000631_abnormal_neuroendocrine_gland0.70251375
138MP0009840_abnormal_foam_cell0.70192101
139MP0003632_abnormal_nervous_system0.69926047
140MP0001919_abnormal_reproductive_system0.69888916
141MP0005551_abnormal_eye_electrophysiolog0.69101269
142MP0002752_abnormal_somatic_nervous0.68045273
143MP0010386_abnormal_urinary_bladder0.66948624
144MP0000026_abnormal_inner_ear0.66412484
145MP0002272_abnormal_nervous_system0.65888936
146MP0005171_absent_coat_pigmentation0.65769321
147MP0010030_abnormal_orbit_morphology0.64705172
148MP0005075_abnormal_melanosome_morpholog0.61276626
149MP0001486_abnormal_startle_reflex0.61198554
150MP0009250_abnormal_appendicular_skeleto0.60781310

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.92650079
2Absent/shortened dynein arms (HP:0200106)4.42524368
3Dynein arm defect of respiratory motile cilia (HP:0012255)4.42524368
4Abnormality of midbrain morphology (HP:0002418)4.13162843
5Molar tooth sign on MRI (HP:0002419)4.13162843
6Intrahepatic cholestasis (HP:0001406)3.91785290
7Pancreatic cysts (HP:0001737)3.82577336
8Abnormal respiratory motile cilium physiology (HP:0012261)3.58225787
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.56417651
10True hermaphroditism (HP:0010459)3.47545503
11Pancreatic fibrosis (HP:0100732)3.41997546
12Adrenal hypoplasia (HP:0000835)3.37350284
133-Methylglutaconic aciduria (HP:0003535)3.36989242
14Abnormality of methionine metabolism (HP:0010901)3.27854371
15Degeneration of the lateral corticospinal tracts (HP:0002314)3.24486696
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.24486696
17Type II lissencephaly (HP:0007260)3.07786472
18Abolished electroretinogram (ERG) (HP:0000550)3.07638681
19Abnormal respiratory epithelium morphology (HP:0012253)3.01199649
20Abnormal respiratory motile cilium morphology (HP:0005938)3.01199649
21Congenital stationary night blindness (HP:0007642)2.92856217
22Prolonged partial thromboplastin time (HP:0003645)2.91296500
23Acute necrotizing encephalopathy (HP:0006965)2.89732238
24Abnormal gallbladder physiology (HP:0012438)2.87933450
25Cholecystitis (HP:0001082)2.87933450
26Abnormality of aspartate family amino acid metabolism (HP:0010899)2.85174321
27Hyperventilation (HP:0002883)2.83326362
28Rhinitis (HP:0012384)2.75712883
29Absent septum pellucidum (HP:0001331)2.75063299
30Infertility (HP:0000789)2.68292147
31Hypoproteinemia (HP:0003075)2.66672910
32Chronic bronchitis (HP:0004469)2.66112900
33Abnormality of monocarboxylic acid metabolism (HP:0010996)2.60806364
34Mitochondrial inheritance (HP:0001427)2.60656180
35Parakeratosis (HP:0001036)2.57375126
36Abnormality of the corticospinal tract (HP:0002492)2.57154050
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.56061783
38Deep venous thrombosis (HP:0002625)2.55634089
39Abnormal ciliary motility (HP:0012262)2.55082385
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.53072095
41Abnormality of T cell number (HP:0011839)2.51416073
42Tubulointerstitial nephritis (HP:0001970)2.51043913
43Abnormal mitochondria in muscle tissue (HP:0008316)2.49889254
44Chromsome breakage (HP:0040012)2.47146379
45Abnormal hair whorl (HP:0010721)2.46995862
46Conjugated hyperbilirubinemia (HP:0002908)2.46482173
47Congenital ichthyosiform erythroderma (HP:0007431)2.46374355
48Retinal dysplasia (HP:0007973)2.45817268
49Hyperlipoproteinemia (HP:0010980)2.44889979
50Focal motor seizures (HP:0011153)2.43804128
51Hypothermia (HP:0002045)2.42051184
52Progressive macrocephaly (HP:0004481)2.41978170
53Limb dystonia (HP:0002451)2.40965661
54Increased CSF lactate (HP:0002490)2.34519858
55Tubular atrophy (HP:0000092)2.34152774
56Abnormality of sulfur amino acid metabolism (HP:0004339)2.33680540
57Polydipsia (HP:0001959)2.33660999
58Abnormal drinking behavior (HP:0030082)2.33660999
59Chronic hepatic failure (HP:0100626)2.32184926
60Abnormal albumin level (HP:0012116)2.31435486
61Hypoalbuminemia (HP:0003073)2.31435486
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31008690
63Hypobetalipoproteinemia (HP:0003563)2.29506305
64T lymphocytopenia (HP:0005403)2.26748944
65Attenuation of retinal blood vessels (HP:0007843)2.25567571
66Abnormality of the septum pellucidum (HP:0007375)2.24442550
67Abnormal spermatogenesis (HP:0008669)2.22967233
68Medial flaring of the eyebrow (HP:0010747)2.21759120
69Global brain atrophy (HP:0002283)2.21420980
70Pendular nystagmus (HP:0012043)2.21240192
71Optic disc pallor (HP:0000543)2.19830182
72Cerebellar dysplasia (HP:0007033)2.19235460
73Osteomalacia (HP:0002749)2.17673679
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16196632
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16196632
76Progressive inability to walk (HP:0002505)2.15646351
77Renal cortical cysts (HP:0000803)2.15387571
78Supernumerary spleens (HP:0009799)2.15296241
79Male infertility (HP:0003251)2.15265715
80Large for gestational age (HP:0001520)2.14812928
81Inability to walk (HP:0002540)2.14668652
82Sclerocornea (HP:0000647)2.13697346
83Nephronophthisis (HP:0000090)2.12756944
84Cystic liver disease (HP:0006706)2.12454445
85Thyroiditis (HP:0100646)2.12034731
86Aplasia/Hypoplasia of the tibia (HP:0005772)2.11530109
87Neurofibrillary tangles (HP:0002185)2.09788509
88Sensory axonal neuropathy (HP:0003390)2.09692026
89Short tibia (HP:0005736)2.09579425
90Lipid accumulation in hepatocytes (HP:0006561)2.09511030
91Septo-optic dysplasia (HP:0100842)2.08444319
92Abnormality of the labia minora (HP:0012880)2.07901576
93Abnormal biliary tract physiology (HP:0012439)2.07419167
94Bile duct proliferation (HP:0001408)2.07419167
95Abnormality of the renal collecting system (HP:0004742)2.06801102
96Increased serum pyruvate (HP:0003542)2.06630091
97Abnormality of glycolysis (HP:0004366)2.06630091
98Lissencephaly (HP:0001339)2.06292643
99Fat malabsorption (HP:0002630)2.06030917
100Impulsivity (HP:0100710)2.05567209
101Duplicated collecting system (HP:0000081)2.05458362
102Congenital, generalized hypertrichosis (HP:0004540)2.03247713
103Congenital hepatic fibrosis (HP:0002612)2.01940776
104IgG deficiency (HP:0004315)2.01791574
105Progressive cerebellar ataxia (HP:0002073)2.00850347
106Abnormality of pyrimidine metabolism (HP:0004353)1.98449666
107Hypophosphatemic rickets (HP:0004912)1.95414201
108Anencephaly (HP:0002323)1.95112157
109Abnormality of the clitoris (HP:0000056)1.94527518
110Generalized aminoaciduria (HP:0002909)1.94342839
111Papillary thyroid carcinoma (HP:0002895)1.94098243
112Methylmalonic aciduria (HP:0012120)1.93766451
113Azoospermia (HP:0000027)1.93756190
114Cerebral hypomyelination (HP:0006808)1.93469377
115Hypochromic microcytic anemia (HP:0004840)1.92997235
116Delayed CNS myelination (HP:0002188)1.92308389
117Abnormality of the pons (HP:0007361)1.92235971
118Steatorrhea (HP:0002570)1.91770028
119Cerebral edema (HP:0002181)1.91215492
120Clitoromegaly (HP:0000057)1.90872265
121Broad-based gait (HP:0002136)1.90780075
122Abnormality of the prostate (HP:0008775)1.90175713
123Methylmalonic acidemia (HP:0002912)1.89588749
124Hypoplasia of the pons (HP:0012110)1.89097014
125Epidermoid cyst (HP:0200040)1.88688833
126Hyperglycinemia (HP:0002154)1.88267168
127Polyuria (HP:0000103)1.86852489
128Concave nail (HP:0001598)1.86834508
129Hepatocellular necrosis (HP:0001404)1.86808460
130Pachygyria (HP:0001302)1.86731645
131Vascular calcification (HP:0004934)1.86501198
132Abnormality of alanine metabolism (HP:0010916)1.85677071
133Hyperalaninemia (HP:0003348)1.85677071
134Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85677071
135Furrowed tongue (HP:0000221)1.85279620
136Abnormality of serum amino acid levels (HP:0003112)1.84730907
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.84330366
138Hepatic necrosis (HP:0002605)1.83175405
139Severe muscular hypotonia (HP:0006829)1.82709415
140Genital tract atresia (HP:0001827)1.82248535
141Renal Fanconi syndrome (HP:0001994)1.82087060
142Abnormality of the renal medulla (HP:0100957)1.82040684
143Increased hepatocellular lipid droplets (HP:0006565)1.81713579
144Malnutrition (HP:0004395)1.81650740
145Vaginal atresia (HP:0000148)1.81591912
146Poor coordination (HP:0002370)1.80078677
147Aplasia/Hypoplasia involving the musculature (HP:0001460)1.79636622
148Nephrogenic diabetes insipidus (HP:0009806)1.78984011
149Male pseudohermaphroditism (HP:0000037)1.77488174
150Joint hemorrhage (HP:0005261)1.77360671
151Lethargy (HP:0001254)1.77044386
152Fair hair (HP:0002286)1.77028506
153Mesangial abnormality (HP:0001966)1.74884969
154Aplasia involving bones of the extremities (HP:0009825)1.74882447
155Aplasia involving bones of the upper limbs (HP:0009823)1.74882447
156Aplasia of the phalanges of the hand (HP:0009802)1.74882447
157Gait imbalance (HP:0002141)1.74224574
158Gaze-evoked nystagmus (HP:0000640)1.73852894
159Patellar aplasia (HP:0006443)1.73677498
160Agitation (HP:0000713)1.73265528
161Abnormality of the renal cortex (HP:0011035)1.72995394
162Aplasia/Hypoplasia of the patella (HP:0006498)1.72923392
163Severe combined immunodeficiency (HP:0004430)1.72731449
164Congenital primary aphakia (HP:0007707)1.71544114
165Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.71411623
166Abnormality of lateral ventricle (HP:0030047)1.71161576
167Xanthomatosis (HP:0000991)1.70496082
168Ectopic kidney (HP:0000086)1.68293947
169Anomalous pulmonary venous return (HP:0010772)1.68139147
170Opisthotonus (HP:0002179)1.67354524
171Ketosis (HP:0001946)1.67093194
172Hypolipoproteinemia (HP:0010981)1.67077268
173Breast hypoplasia (HP:0003187)1.66457839
174Acute encephalopathy (HP:0006846)1.66153668
175Hypergonadotropic hypogonadism (HP:0000815)1.66105390
176Abnormality of the phalanges of the hallux (HP:0010057)1.64388071
177Postaxial foot polydactyly (HP:0001830)1.64267057
178Abnormality of incisor morphology (HP:0011063)1.63814873
179Cortical dysplasia (HP:0002539)1.63227712
180Autoamputation (HP:0001218)1.62688459
181Amniotic constriction ring (HP:0009775)1.59955920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.73068971
2PRPF4B4.04659321
3FRK3.41994602
4ACVR1B2.74728022
5LATS12.62642249
6ERBB42.61931662
7STK392.51554075
8WNK32.46350569
9INSRR2.44252638
10BRAF2.38840056
11CASK2.31710510
12STK38L2.17029420
13MUSK2.15278400
14PLK42.14229455
15BMPR22.10641446
16MAP4K22.10342643
17AKT32.06577662
18GRK12.00830699
19PDK31.99996560
20PDK41.99996560
21BCR1.94297303
22CAMKK21.92979085
23BMPR1B1.92674993
24SGK2231.91951390
25SGK4941.91951390
26DYRK21.89718995
27MAP2K71.86952971
28OXSR11.79215112
29TTK1.72738384
30PDK21.70907980
31PNCK1.70305278
32ZAK1.67003512
33TNIK1.62317260
34TRIM281.56406249
35TLK11.55801052
36MKNK21.53509614
37SGK21.52834247
38PINK11.51833301
39MAP3K61.48075934
40TESK11.46047514
41SRPK11.45878448
42PRKD31.45362541
43MAPK131.43350607
44ARAF1.42761728
45DAPK21.34162301
46NEK61.34151594
47PKN11.33677094
48MAPKAPK51.28128103
49STK31.26756600
50CSNK1G31.25824995
51CSNK1A1L1.24565772
52BCKDK1.19465804
53TAOK31.18918165
54GRK71.18161429
55ITK1.15170910
56NTRK31.13217254
57WEE11.10708636
58CSNK1G11.10117372
59NUAK11.08254083
60CDK31.06194897
61LATS21.05047814
62BRSK21.03242167
63CSNK1G21.02157515
64PBK0.96904166
65TRPM70.95528086
66MST40.92457505
67CHEK20.91852068
68LIMK10.90380038
69CDC70.89368608
70FGFR20.88275022
71MKNK10.87123717
72ADRBK10.86436078
73MAPKAPK30.82138763
74TGFBR10.79794998
75VRK20.77259245
76OBSCN0.76694229
77MAP3K40.75943350
78MAP3K120.75775979
79NTRK20.74952837
80PAK30.74664098
81SYK0.74067927
82PHKG10.73204628
83PHKG20.73204628
84SGK30.72422935
85PIK3CA0.71467168
86PLK20.71126238
87WNK40.70224246
88PLK10.70024278
89PRKCE0.70010732
90MARK10.69726889
91EIF2AK30.69635596
92PLK30.69279018
93MELK0.69231677
94AURKA0.68545223
95YES10.63294590
96TEC0.62022725
97EIF2AK10.60952541
98CAMK2A0.60330899
99RPS6KA50.59610760
100ICK0.56288553
101TESK20.55968566
102PIK3CG0.54919902
103MAP2K40.54898506
104CAMK2G0.53996798
105PRKACA0.53074133
106CDK80.51216123
107IKBKB0.50917707
108CAMK2B0.50770892
109MARK30.47566790
110VRK10.46463939
111STK110.45359287
112TIE10.44894949
113TYRO30.43645625
114SIK30.43270058
115EPHA40.41792652
116PIM10.41602155
117SCYL20.41553609
118LCK0.41141046
119PRKCA0.40801249
120NEK20.39946778
121CSNK1A10.39283769
122MET0.39261192
123DYRK1B0.39052505
124PRKG10.39032877
125MAP3K140.38999491
126CAMK10.37290968
127MATK0.37211651
128PRKCQ0.36867126
129NLK0.36289740
130STK240.35491932
131ERBB30.35029685
132ADRBK20.34210736
133MINK10.34166957
134RPS6KB10.33920548
135CDK120.33372073
136CSF1R0.32967674
137PRKCZ0.32091226
138DYRK1A0.32076051
139PRKCG0.31868519
140PRKAA20.31307592
141LYN0.31127443
142MAP3K130.30998424
143CDK90.30763144
144TAOK10.30193713
145CAMK40.30036304
146ROCK20.29700436
147CAMK2D0.29265681
148PTK2B0.29228636
149PRKAA10.28935074
150CSNK1D0.28927536
151MAPK150.28793664
152MAP2K60.28148160
153KDR0.28139676
154STK160.27894477
155IGF1R0.27818406
156CSNK2A10.26848379

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.17263576
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.00917544
3Vitamin B6 metabolism_Homo sapiens_hsa007502.87987436
4Steroid biosynthesis_Homo sapiens_hsa001002.83506344
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81663010
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.64701116
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.63584911
8Fatty acid elongation_Homo sapiens_hsa000622.60636409
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.34119154
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.33564104
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.30310879
12Parkinsons disease_Homo sapiens_hsa050122.30160885
13Histidine metabolism_Homo sapiens_hsa003402.25627136
14Steroid hormone biosynthesis_Homo sapiens_hsa001402.22899466
15Phototransduction_Homo sapiens_hsa047442.18331560
16Chemical carcinogenesis_Homo sapiens_hsa052042.11911053
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.11507350
18Primary immunodeficiency_Homo sapiens_hsa053402.08359817
19Linoleic acid metabolism_Homo sapiens_hsa005912.00732159
20Peroxisome_Homo sapiens_hsa041462.00580934
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.96404157
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.92680156
23Propanoate metabolism_Homo sapiens_hsa006401.90469425
24Retinol metabolism_Homo sapiens_hsa008301.84378100
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82122057
26Ether lipid metabolism_Homo sapiens_hsa005651.78487238
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76753484
28Butanoate metabolism_Homo sapiens_hsa006501.76270230
29Basal transcription factors_Homo sapiens_hsa030221.74097471
30Sulfur metabolism_Homo sapiens_hsa009201.73647040
31Autoimmune thyroid disease_Homo sapiens_hsa053201.70868729
32Pyruvate metabolism_Homo sapiens_hsa006201.70850243
33Nicotine addiction_Homo sapiens_hsa050331.70636779
34Graft-versus-host disease_Homo sapiens_hsa053321.67007268
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.59404845
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59140894
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59028149
38beta-Alanine metabolism_Homo sapiens_hsa004101.52446462
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51830979
40Fatty acid degradation_Homo sapiens_hsa000711.51286472
41Rheumatoid arthritis_Homo sapiens_hsa053231.48007729
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44723251
43Tryptophan metabolism_Homo sapiens_hsa003801.43364341
44Allograft rejection_Homo sapiens_hsa053301.41134620
45Alzheimers disease_Homo sapiens_hsa050101.38414937
46Complement and coagulation cascades_Homo sapiens_hsa046101.38045715
47Arginine biosynthesis_Homo sapiens_hsa002201.37118650
48Glutathione metabolism_Homo sapiens_hsa004801.36128182
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34159473
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31853374
51Fatty acid metabolism_Homo sapiens_hsa012121.31111214
52Tyrosine metabolism_Homo sapiens_hsa003501.31093318
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.28344656
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27669389
55Type I diabetes mellitus_Homo sapiens_hsa049401.27643251
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20226567
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18812630
58Folate biosynthesis_Homo sapiens_hsa007901.18340884
59PPAR signaling pathway_Homo sapiens_hsa033201.17600468
60Asthma_Homo sapiens_hsa053101.15132077
61Cardiac muscle contraction_Homo sapiens_hsa042601.14348952
62Arginine and proline metabolism_Homo sapiens_hsa003301.13442878
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.13039808
64Cyanoamino acid metabolism_Homo sapiens_hsa004601.12994111
65Arachidonic acid metabolism_Homo sapiens_hsa005901.12218137
66Phenylalanine metabolism_Homo sapiens_hsa003601.04108807
67Fanconi anemia pathway_Homo sapiens_hsa034601.03359362
68Vitamin digestion and absorption_Homo sapiens_hsa049770.99537685
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.98563411
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95487684
71Ovarian steroidogenesis_Homo sapiens_hsa049130.94723231
72Morphine addiction_Homo sapiens_hsa050320.94675200
73ABC transporters_Homo sapiens_hsa020100.94113636
74Selenocompound metabolism_Homo sapiens_hsa004500.92045697
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88667391
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86511370
77Olfactory transduction_Homo sapiens_hsa047400.86466459
78GABAergic synapse_Homo sapiens_hsa047270.85835134
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85180109
80Non-homologous end-joining_Homo sapiens_hsa034500.84995164
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83638251
82Metabolic pathways_Homo sapiens_hsa011000.81639818
83RNA degradation_Homo sapiens_hsa030180.74314559
84Fatty acid biosynthesis_Homo sapiens_hsa000610.74001180
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.72711851
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71201092
87Hematopoietic cell lineage_Homo sapiens_hsa046400.70935319
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70747631
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69073235
90Homologous recombination_Homo sapiens_hsa034400.68096423
91Sphingolipid metabolism_Homo sapiens_hsa006000.67620814
92Sulfur relay system_Homo sapiens_hsa041220.67216966
93Bile secretion_Homo sapiens_hsa049760.66596912
94Antigen processing and presentation_Homo sapiens_hsa046120.66338278
95Circadian entrainment_Homo sapiens_hsa047130.66016641
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62330907
97Circadian rhythm_Homo sapiens_hsa047100.61853067
98One carbon pool by folate_Homo sapiens_hsa006700.61526195
99Taste transduction_Homo sapiens_hsa047420.59855463
100Regulation of autophagy_Homo sapiens_hsa041400.59012709
101Biosynthesis of amino acids_Homo sapiens_hsa012300.57837209
102Purine metabolism_Homo sapiens_hsa002300.57224013
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56764232
104Glutamatergic synapse_Homo sapiens_hsa047240.55920433
105RNA polymerase_Homo sapiens_hsa030200.54862908
106Insulin secretion_Homo sapiens_hsa049110.54302133
107Cell cycle_Homo sapiens_hsa041100.50876664
108Starch and sucrose metabolism_Homo sapiens_hsa005000.48528801
109Nitrogen metabolism_Homo sapiens_hsa009100.44824031
110Dopaminergic synapse_Homo sapiens_hsa047280.44500215
111Glycerolipid metabolism_Homo sapiens_hsa005610.44343509
112Carbon metabolism_Homo sapiens_hsa012000.39408457
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39191190
114Pyrimidine metabolism_Homo sapiens_hsa002400.37674371
115Protein export_Homo sapiens_hsa030600.37386354
116Base excision repair_Homo sapiens_hsa034100.37152153
117Fat digestion and absorption_Homo sapiens_hsa049750.36696896
118Huntingtons disease_Homo sapiens_hsa050160.33157866
119Oxidative phosphorylation_Homo sapiens_hsa001900.31225387
120TGF-beta signaling pathway_Homo sapiens_hsa043500.26199551
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25455054
122Collecting duct acid secretion_Homo sapiens_hsa049660.24147641
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19585867
124Staphylococcus aureus infection_Homo sapiens_hsa051500.19421322
125Caffeine metabolism_Homo sapiens_hsa002320.18470691
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18278755
127Mineral absorption_Homo sapiens_hsa049780.17819075
128Nucleotide excision repair_Homo sapiens_hsa034200.16891647
129Serotonergic synapse_Homo sapiens_hsa047260.16841873
130Proteasome_Homo sapiens_hsa030500.12013289
131Oocyte meiosis_Homo sapiens_hsa041140.09023982
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08284875
133Axon guidance_Homo sapiens_hsa043600.07806454
134Lysine degradation_Homo sapiens_hsa003100.02594243
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.02180994

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