LRRC30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)9.95761655
2skeletal muscle fiber development (GO:0048741)8.07485247
3response to stimulus involved in regulation of muscle adaptation (GO:0014874)7.54405625
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.45967513
5actin filament-based movement (GO:0030048)7.42636701
6glycogen catabolic process (GO:0005980)7.21268348
7striated muscle atrophy (GO:0014891)6.92567509
8myotube cell development (GO:0014904)6.90012616
9glucan catabolic process (GO:0009251)6.76036694
10plasma membrane repair (GO:0001778)6.63045692
11skeletal muscle tissue regeneration (GO:0043403)6.53580431
12creatine metabolic process (GO:0006600)6.51010200
13striated muscle contraction (GO:0006941)6.46912869
14carnitine shuttle (GO:0006853)6.46533263
15purine nucleotide salvage (GO:0032261)6.34145567
16sarcomere organization (GO:0045214)6.33352298
17cellular polysaccharide catabolic process (GO:0044247)6.30083393
18regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)6.06805252
19muscle atrophy (GO:0014889)6.03743969
20polysaccharide catabolic process (GO:0000272)5.96558787
21response to inactivity (GO:0014854)5.90132762
22response to muscle activity (GO:0014850)5.89762937
23regulation of cell communication by electrical coupling (GO:0010649)5.89322488
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.72063246
25myofibril assembly (GO:0030239)5.65331870
26pyrimidine ribonucleoside catabolic process (GO:0046133)5.63790985
27striated muscle adaptation (GO:0014888)5.55947961
28muscle contraction (GO:0006936)5.53956432
29glycogen biosynthetic process (GO:0005978)5.46956951
30glucan biosynthetic process (GO:0009250)5.46956951
31IMP metabolic process (GO:0046040)5.45347187
32fatty acid transmembrane transport (GO:1902001)5.42391383
33cytidine deamination (GO:0009972)5.20896835
34cytidine metabolic process (GO:0046087)5.20896835
35cytidine catabolic process (GO:0006216)5.20896835
36regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.08451904
37muscle system process (GO:0003012)4.91390115
38muscle fiber development (GO:0048747)4.87601487
39glycogen metabolic process (GO:0005977)4.84471553
40carnitine transmembrane transport (GO:1902603)4.77355445
41cellular glucan metabolic process (GO:0006073)4.74969029
42glucan metabolic process (GO:0044042)4.74969029
43regulation of acyl-CoA biosynthetic process (GO:0050812)4.64765967
44cellular response to dexamethasone stimulus (GO:0071549)4.52929578
45positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.50057888
46muscle adaptation (GO:0043500)4.49854804
47actomyosin structure organization (GO:0031032)4.46590940
48neuronal action potential propagation (GO:0019227)4.43227047
49amino-acid betaine transport (GO:0015838)4.36919700
50carnitine transport (GO:0015879)4.36919700
51negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.28349200
52IMP biosynthetic process (GO:0006188)4.25354676
53response to dexamethasone (GO:0071548)4.23702589
54regulation of coenzyme metabolic process (GO:0051196)4.23618983
55regulation of cofactor metabolic process (GO:0051193)4.23618983
56response to activity (GO:0014823)4.09784683
57cellular carbohydrate catabolic process (GO:0044275)4.06869713
58negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.03347849
59negative regulation of skeletal muscle tissue development (GO:0048642)4.00267182
60neuromuscular synaptic transmission (GO:0007274)3.99733469
61regulation of skeletal muscle cell differentiation (GO:2001014)3.95160813
62muscle organ development (GO:0007517)3.82913361
63negative regulation of muscle hypertrophy (GO:0014741)3.80340110
64muscle structure development (GO:0061061)3.78119832
65myotube differentiation (GO:0014902)3.77390029
66muscle cell cellular homeostasis (GO:0046716)3.69801806
67cardiac muscle contraction (GO:0060048)3.68193715
68regulation of relaxation of muscle (GO:1901077)3.64765808
69regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.64300845
70tricarboxylic acid cycle (GO:0006099)3.59988439
71negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.57977844
72striated muscle cell development (GO:0055002)3.56600509
73skeletal muscle tissue development (GO:0007519)3.52741140
74regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.49135544
75regulation of calcium ion transmembrane transport (GO:1903169)3.48875104
76regulation of calcium ion transmembrane transporter activity (GO:1901019)3.48875104
77heart contraction (GO:0060047)3.46787924
78heart process (GO:0003015)3.46787924
79regulation of sulfur metabolic process (GO:0042762)3.43461183
80cellular polysaccharide metabolic process (GO:0044264)3.39746628
81positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.36078804
82regulation of actin filament-based movement (GO:1903115)3.29106982
83cellular polysaccharide biosynthetic process (GO:0033692)3.22458248
84intracellular lipid transport (GO:0032365)3.21800822
85positive regulation of myotube differentiation (GO:0010831)3.18070795
86polysaccharide biosynthetic process (GO:0000271)3.17714157
87negative regulation of cAMP-mediated signaling (GO:0043951)3.17466780
88polysaccharide metabolic process (GO:0005976)3.11847716
89regulation of striated muscle contraction (GO:0006942)3.11224953
90positive regulation of myoblast differentiation (GO:0045663)3.10615125
91neuromuscular junction development (GO:0007528)3.07469380
92myoblast fusion (GO:0007520)3.07134444
93quaternary ammonium group transport (GO:0015697)3.06634391
94negative regulation of potassium ion transmembrane transport (GO:1901380)3.04813107
95muscle filament sliding (GO:0030049)12.1984472
96actin-myosin filament sliding (GO:0033275)12.1984472
97regulation of skeletal muscle contraction (GO:0014819)12.1586087
98skeletal muscle contraction (GO:0003009)11.0183776
99skeletal muscle adaptation (GO:0043501)10.9132141
100sarcoplasmic reticulum calcium ion transport (GO:0070296)10.6943204

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.22369730
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.27171474
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.61632610
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.50303096
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.27818129
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.01712777
7BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.87554822
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.72365476
9ZNF263_19887448_ChIP-Seq_K562_Human2.55130275
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.52064233
11TBX20_22080862_ChIP-Seq_HEART_Mouse2.48067512
12TBX20_22328084_ChIP-Seq_HEART_Mouse2.48067512
13AR_21572438_ChIP-Seq_LNCaP_Human2.07792381
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03407251
15CTCF_21964334_ChIP-Seq_BJAB-B_Human1.89056720
16MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.85398435
17ZNF274_21170338_ChIP-Seq_K562_Hela1.83776120
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75312351
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.68239611
20CTCF_27219007_Chip-Seq_Bcells_Human1.66125167
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.65302259
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61399939
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.61087449
24CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.59290511
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.56399777
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48894629
27EZH2_22144423_ChIP-Seq_EOC_Human1.45126335
28STAT1_20625510_ChIP-Seq_HELA_Human1.44231186
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39696776
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38349303
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.37958029
32FOXH1_21741376_ChIP-Seq_ESCs_Human1.37742824
33SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37345891
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35818217
35SA1_27219007_Chip-Seq_Bcells_Human1.34195317
36TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32835478
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.31965708
38* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31658875
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29921332
40TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28148891
41CLOCK_20551151_ChIP-Seq_293T_Human1.27659560
42GATA4_21415370_ChIP-Seq_HL-1_Mouse1.25015919
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24833023
44KDM2B_26808549_Chip-Seq_DND41_Human1.23481301
45CBP_20019798_ChIP-Seq_JUKART_Human1.23409329
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23409329
47OCT4_20526341_ChIP-Seq_ESCs_Human1.20943277
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19401740
49SMC1_22415368_ChIP-Seq_MEFs_Mouse1.17646013
50DROSHA_22980978_ChIP-Seq_HELA_Human1.17415882
51YY1_22570637_ChIP-Seq_MALME-3M_Human1.16018903
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15441692
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.14790045
54SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14431149
55CTCF_21964334_Chip-Seq_Bcells_Human1.12793083
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11722478
57CREB1_26743006_Chip-Seq_LNCaP_Human1.10934508
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08519392
59NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05842648
60MYC_27129775_Chip-Seq_CORNEA_Mouse1.05023335
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02082014
62TCF7_22412390_ChIP-Seq_EML_Mouse0.99413823
63CTCF_26484167_Chip-Seq_Bcells_Mouse0.99341455
64ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99236017
65FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98933570
66NANOG_20526341_ChIP-Seq_ESCs_Human0.98916059
67LXR_22158963_ChIP-Seq_LIVER_Mouse0.98177532
68RAC3_21632823_ChIP-Seq_H3396_Human0.98087040
69NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98051762
70TP53_20018659_ChIP-ChIP_R1E_Mouse0.97364030
71MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96962801
72GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.95251831
73LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.93256929
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93075364
75SPI1_20517297_ChIP-Seq_HL60_Human0.92257017
76RACK7_27058665_Chip-Seq_MCF-7_Human0.91840980
77EZH2_27294783_Chip-Seq_ESCs_Mouse0.91146060
78RARB_27405468_Chip-Seq_BRAIN_Mouse0.90753669
79CEBPB_22108803_ChIP-Seq_LS180_Human0.90709858
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90008853
81P68_20966046_ChIP-Seq_HELA_Human0.89975688
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89516629
83NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89516629
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88888239
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88031398
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87065820
87OCT1_27270436_Chip-Seq_PROSTATE_Human0.87040736
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.86797617
89STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86717982
90* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85747310
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84157524
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.83797901
93P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83454650
94CBP_21632823_ChIP-Seq_H3396_Human0.83037233
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82651702
96E2F1_20622854_ChIP-Seq_HELA_Human0.82291125
97LXR_22292898_ChIP-Seq_THP-1_Human0.81561734
98ATF3_27146783_Chip-Seq_COLON_Human0.80988360
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80487192
100KLF4_19829295_ChIP-Seq_ESCs_Human0.79264836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio8.47458492
2MP0003646_muscle_fatigue6.57895015
3MP0000749_muscle_degeneration6.33272763
4MP0000751_myopathy5.51322030
5MP0000747_muscle_weakness4.43952468
6MP0002106_abnormal_muscle_physiology4.28685837
7MP0004036_abnormal_muscle_relaxation4.02126860
8MP0000759_abnormal_skeletal_muscle3.86555798
9MP0002269_muscular_atrophy3.72224925
10MP0004130_abnormal_muscle_cell3.59149929
11MP0005369_muscle_phenotype3.55908649
12MP0004087_abnormal_muscle_fiber3.38245357
13MP0002837_dystrophic_cardiac_calcinosis3.30911263
14MP0000750_abnormal_muscle_regeneration3.22285897
15MP0005620_abnormal_muscle_contractility3.10335167
16MP0004233_abnormal_muscle_weight2.89060470
17MP0000733_abnormal_muscle_development2.37014658
18MP0002332_abnormal_exercise_endurance2.28485811
19MP0002108_abnormal_muscle_morphology2.01287767
20MP0006036_abnormal_mitochondrial_physio2.00200746
21MP0005330_cardiomyopathy1.77817476
22MP0004185_abnormal_adipocyte_glucose1.71640447
23MP0004084_abnormal_cardiac_muscle1.47796054
24MP0004270_analgesia1.43013802
25MP0003806_abnormal_nucleotide_metabolis1.38669614
26MP0005666_abnormal_adipose_tissue1.37804654
27MP0002971_abnormal_brown_adipose1.36783819
28MP0003221_abnormal_cardiomyocyte_apopto1.22928797
29MP0004215_abnormal_myocardial_fiber1.19003340
30MP0004484_altered_response_of1.17529534
31MP0002972_abnormal_cardiac_muscle1.17028442
32MP0005266_abnormal_metabolism1.13681928
33MP0006035_abnormal_mitochondrial_morpho1.10749607
34MP0010630_abnormal_cardiac_muscle1.10323613
35MP0000013_abnormal_adipose_tissue1.05657220
36MP0005375_adipose_tissue_phenotype1.04630912
37MP0004134_abnormal_chest_morphology0.88099160
38MP0003656_abnormal_erythrocyte_physiolo0.87275756
39MP0003950_abnormal_plasma_membrane0.82725935
40MP0004147_increased_porphyrin_level0.82223018
41MP0004043_abnormal_pH_regulation0.81071365
42MP0005385_cardiovascular_system_phenoty0.80441443
43MP0001544_abnormal_cardiovascular_syste0.80441443
44MP0000372_irregular_coat_pigmentation0.79669742
45MP0003705_abnormal_hypodermis_morpholog0.74426857
46MP0001299_abnormal_eye_distance/0.74129517
47MP0002234_abnormal_pharynx_morphology0.73984725
48MP0009250_abnormal_appendicular_skeleto0.72551545
49MP0005334_abnormal_fat_pad0.71947199
50MP0003137_abnormal_impulse_conducting0.68961800
51MP0008961_abnormal_basal_metabolism0.67913849
52MP0002078_abnormal_glucose_homeostasis0.66501079
53MP0005670_abnormal_white_adipose0.64422572
54MP0000003_abnormal_adipose_tissue0.59573384
55MP0000762_abnormal_tongue_morphology0.56932080
56MP0005083_abnormal_biliary_tract0.55100473
57MP0005584_abnormal_enzyme/coenzyme_acti0.54923058
58MP0000266_abnormal_heart_morphology0.51000324
59MP0003959_abnormal_lean_body0.49457588
60MP0002127_abnormal_cardiovascular_syste0.48203976
61MP0005452_abnormal_adipose_tissue0.48011386
62MP0002089_abnormal_postnatal_growth/wei0.47672066
63MP0008569_lethality_at_weaning0.46760427
64MP0004142_abnormal_muscle_tone0.45773537
65MP0000343_altered_response_to0.45723904
66MP0008775_abnormal_heart_ventricle0.45368606
67MP0002896_abnormal_bone_mineralization0.42735735
68MP0009672_abnormal_birth_weight0.38411617
69MP0005319_abnormal_enzyme/_coenzyme0.38360026
70MP0003045_fibrosis0.36761721
71MP0003195_calcinosis0.35949511
72MP0001849_ear_inflammation0.33163963
73MP0002114_abnormal_axial_skeleton0.32591094
74MP0003948_abnormal_gas_homeostasis0.30283575
75MP0009115_abnormal_fat_cell0.30192571
76MP0005376_homeostasis/metabolism_phenot0.29850703
77MP0006138_congestive_heart_failure0.29109001
78MP0005535_abnormal_body_temperature0.27807481
79MP0002118_abnormal_lipid_homeostasis0.27684164
80MP0002139_abnormal_hepatobiliary_system0.27003442
81MP0000230_abnormal_systemic_arterial0.26483531
82MP0008770_decreased_survivor_rate0.22575406
83MP0003567_abnormal_fetal_cardiomyocyte0.21847236
84MP0004085_abnormal_heartbeat0.21579094
85MP0001943_abnormal_respiration0.21474541
86MP0002066_abnormal_motor_capabilities/c0.21057958
87MP0001853_heart_inflammation0.20722575
88MP0005166_decreased_susceptibility_to0.19897314
89MP0004859_abnormal_synaptic_plasticity0.19480373
90MP0001243_abnormal_dermal_layer0.19218093
91MP0000383_abnormal_hair_follicle0.18815595
92MP0004510_myositis0.18180384
93MP0000678_abnormal_parathyroid_gland0.18020330
94MP0005076_abnormal_cell_differentiation0.17272243
95MP0003828_pulmonary_edema0.17178480
96MP0005275_abnormal_skin_tensile0.16851395
97MP0002128_abnormal_blood_circulation0.16438535
98MP0002970_abnormal_white_adipose0.15062721
99MP0003956_abnormal_body_size0.14971384
100MP0002932_abnormal_joint_morphology0.14922010

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.94409134
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.57370164
3Exercise-induced myalgia (HP:0003738)8.95265236
4Nemaline bodies (HP:0003798)8.86316463
5Exercise-induced muscle cramps (HP:0003710)8.14881336
6Distal arthrogryposis (HP:0005684)7.09047555
7Muscle hypertrophy of the lower extremities (HP:0008968)7.03508113
8Type 1 muscle fiber predominance (HP:0003803)7.01898530
9Myopathic facies (HP:0002058)6.73742203
10Round ear (HP:0100830)6.15431922
11Calf muscle hypertrophy (HP:0008981)6.14635977
12Ulnar deviation of the wrist (HP:0003049)6.05190474
13Difficulty running (HP:0009046)5.62615012
14Myoglobinuria (HP:0002913)5.45200151
15Calcaneovalgus deformity (HP:0001848)5.30313277
16Muscle fiber splitting (HP:0003555)5.18611567
17Muscle stiffness (HP:0003552)5.08866993
18Absent phalangeal crease (HP:0006109)5.01135168
19Deformed tarsal bones (HP:0008119)4.78754089
20Hyporeflexia of lower limbs (HP:0002600)4.76817441
21Rhabdomyolysis (HP:0003201)4.57621094
22EMG: myopathic abnormalities (HP:0003458)4.52943292
23Myotonia (HP:0002486)4.26639362
24Increased connective tissue (HP:0009025)4.20065512
25Abnormal finger flexion creases (HP:0006143)4.20002114
26Abnormality of the calf musculature (HP:0001430)4.04937099
27Subaortic stenosis (HP:0001682)3.71216592
28Abnormality of the left ventricular outflow tract (HP:0011103)3.71216592
29Abnormality of skeletal muscle fiber size (HP:0012084)3.64586090
30Malignant hyperthermia (HP:0002047)3.60181144
31Rimmed vacuoles (HP:0003805)3.53214005
32Shoulder girdle muscle weakness (HP:0003547)3.52046859
33Pelvic girdle muscle weakness (HP:0003749)3.51608353
34Neck muscle weakness (HP:0000467)3.40599108
35Abnormality of the musculature of the pelvis (HP:0001469)3.40019966
36Abnormality of the hip-girdle musculature (HP:0001445)3.40019966
37Difficulty climbing stairs (HP:0003551)3.38257345
38Increased variability in muscle fiber diameter (HP:0003557)3.29309564
39Hyperkalemia (HP:0002153)3.25067923
40Abnormality of the calcaneus (HP:0008364)3.19786200
41Areflexia of lower limbs (HP:0002522)3.18983272
42Frequent falls (HP:0002359)3.04310540
43Asymmetric septal hypertrophy (HP:0001670)2.91558898
44Paralysis (HP:0003470)2.74481684
45Abnormality of the neuromuscular junction (HP:0003398)2.57381552
46Fatigable weakness (HP:0003473)2.57381552
47Sudden death (HP:0001699)2.43751618
48Slender build (HP:0001533)2.42324037
49EMG: neuropathic changes (HP:0003445)2.41551692
50Muscular dystrophy (HP:0003560)2.41034676
51Limb-girdle muscle weakness (HP:0003325)2.35416262
52Distal lower limb muscle weakness (HP:0009053)2.34977542
53Hypoplastic ischia (HP:0003175)2.29294243
54Nonprogressive disorder (HP:0003680)2.25569448
55Proximal amyotrophy (HP:0007126)2.17376873
56Generalized muscle weakness (HP:0003324)2.13519611
57Abnormality of the shoulder girdle musculature (HP:0001435)2.08714299
58Bulbar palsy (HP:0001283)2.08051271
59Mildly elevated creatine phosphokinase (HP:0008180)2.04230930
60Facial diplegia (HP:0001349)2.02908652
61Ulnar deviation of finger (HP:0009465)2.01940321
62Abnormality of the ischium (HP:0003174)2.00636952
63Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98135421
64Gowers sign (HP:0003391)1.98117598
65Limb-girdle muscle atrophy (HP:0003797)1.97893011
66Metatarsus adductus (HP:0001840)1.96264236
67Scapular winging (HP:0003691)1.92670495
68Progressive muscle weakness (HP:0003323)1.91979110
69Achilles tendon contracture (HP:0001771)1.89717678
70Spinal rigidity (HP:0003306)1.88856501
71Centrally nucleated skeletal muscle fibers (HP:0003687)1.88687896
72Increased purine levels (HP:0004368)1.84666846
73Hyperuricemia (HP:0002149)1.84666846
74Distal lower limb amyotrophy (HP:0008944)1.83293955
75Weak cry (HP:0001612)1.81723391
76Increased density of long bones (HP:0006392)1.76356078
77Stridor (HP:0010307)1.75189807
78Abnormality of the Achilles tendon (HP:0005109)1.73510483
79Waddling gait (HP:0002515)1.72842432
80Oligomenorrhea (HP:0000876)1.70194002
81Cholelithiasis (HP:0001081)1.68835378
82Short palpebral fissure (HP:0012745)1.67695324
83Abnormality of potassium homeostasis (HP:0011042)1.66698329
84Gout (HP:0001997)1.65337750
85Fetal akinesia sequence (HP:0001989)1.61130010
86Tarsal synostosis (HP:0008368)1.60209297
87Toxemia of pregnancy (HP:0100603)1.57539180
88Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.56956478
89Ventricular tachycardia (HP:0004756)1.55284295
90Abnormal gallbladder morphology (HP:0012437)1.49889711
91Exercise intolerance (HP:0003546)1.46660915
92Insulin-resistant diabetes mellitus (HP:0000831)1.45551441
93Adducted thumb (HP:0001181)1.45229832
94Hip contracture (HP:0003273)1.44401941
95Hypoalphalipoproteinemia (HP:0003233)1.44197121
96Long clavicles (HP:0000890)1.43916386
97Synostosis involving bones of the lower limbs (HP:0009138)1.43829556
98Synostosis involving bones of the feet (HP:0009140)1.43829556
99Respiratory insufficiency due to muscle weakness (HP:0002747)1.42653947
100Hypokalemia (HP:0002900)1.41779575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.91817912
2TTN6.28584485
3PHKG25.94672244
4PHKG15.94672244
5NME14.96406099
6PIK3CG3.55857951
7MAP2K33.07151176
8NEK12.43801632
9MAP3K72.28428952
10PINK12.17534315
11PDK31.94396910
12PDK41.94396910
13MAP2K41.81426886
14TRIB31.75101646
15DMPK1.75082951
16MAPK121.71711958
17BCKDK1.68150543
18PIK3CA1.60423870
19MAP2K61.51891650
20PDK21.29396420
21MUSK1.18376516
22PRKAA21.01049215
23NEK91.00749673
24PRKAA10.95398809
25ERBB30.81978859
26MAP3K30.80806955
27TAOK20.79158168
28TRPM70.68981301
29ZAK0.67157274
30STK240.65725805
31MAPK110.61761391
32MAPKAPK30.59932130
33CAMK2G0.58137740
34MAP3K110.54881928
35AKT20.54216525
36PKN20.51161822
37TAOK10.45769873
38EPHB10.44466615
39ILK0.42158508
40SIK10.41305898
41PTK60.39876809
42RIPK10.38646753
43LIMK10.37962748
44SGK10.33677112
45MAP3K60.33445943
46PKN10.32327362
47MAP3K100.31354820
48KSR20.31064866
49PRKACB0.28701544
50EEF2K0.27969655
51MAP3K50.27873913
52RPS6KA30.27299027
53PNCK0.26104248
54PRKG10.25063249
55INSRR0.24861080
56MAP3K10.24517372
57CAMK1G0.23301890
58MAPK70.21747845
59MAPK40.21173161
60PRKACA0.18875792
61TYK20.16534133
62PDPK10.16519979
63PDK10.15389919
64PAK60.14441350
65MOS0.13918763
66TIE10.13484089
67ROCK10.12925467
68MAP2K10.11685080
69RPS6KA10.09435476
70PRKD10.09405544
71CAMK2D0.07827224
72BMX0.07668270
73PRKACG0.07007595
74STK110.06935924
75MAPK100.06820032
76SGK30.06690273
77DYRK1B0.06080036
78MAP3K40.05708143
79ICK0.05235715
80CCNB10.04367978
81MTOR0.04090770
82KSR10.03912073
83TGFBR20.03713950
84LRRK20.03701219
85JAK20.03508757
86LATS20.02631883
87CSNK1D0.02470360
88PTK2B0.02218512
89MAPK80.02137114
90GSK3A0.01452252
91FGFR10.01288901
92ROCK2-0.0445426
93PRKCA-0.0433313
94PRKCB-0.0420714
95MAP3K8-0.0373145
96RPS6KB1-0.0296933
97MAPK9-0.0139660
98PRKDC-0.0112573
99RPS6KA2-0.0095516
100LATS1-0.0029678

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.27280797
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.14044970
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.58089931
4Cardiac muscle contraction_Homo sapiens_hsa042603.46044476
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.36834879
6Dilated cardiomyopathy_Homo sapiens_hsa054143.21172217
7Starch and sucrose metabolism_Homo sapiens_hsa005003.19208130
8Circadian rhythm_Homo sapiens_hsa047102.73067044
9Glucagon signaling pathway_Homo sapiens_hsa049222.55365727
10Propanoate metabolism_Homo sapiens_hsa006402.51741560
11Insulin signaling pathway_Homo sapiens_hsa049102.44273847
12Oxytocin signaling pathway_Homo sapiens_hsa049212.35564415
13Carbon metabolism_Homo sapiens_hsa012002.23764652
14Insulin resistance_Homo sapiens_hsa049312.22251368
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.10292661
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.05128836
17Galactose metabolism_Homo sapiens_hsa000521.87834481
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.85484291
19AMPK signaling pathway_Homo sapiens_hsa041521.84576846
20Calcium signaling pathway_Homo sapiens_hsa040201.74454279
21Fructose and mannose metabolism_Homo sapiens_hsa000511.73577974
22Parkinsons disease_Homo sapiens_hsa050121.69644596
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68022315
24Alzheimers disease_Homo sapiens_hsa050101.58809296
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.56267651
26Biosynthesis of amino acids_Homo sapiens_hsa012301.54125876
27Pyruvate metabolism_Homo sapiens_hsa006201.52638030
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46133558
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.41792651
30Oxidative phosphorylation_Homo sapiens_hsa001901.40673914
31Fatty acid degradation_Homo sapiens_hsa000711.38005315
32Viral myocarditis_Homo sapiens_hsa054161.37016906
33Arginine and proline metabolism_Homo sapiens_hsa003301.35154710
34Pentose phosphate pathway_Homo sapiens_hsa000301.22477983
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20232496
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17177345
37Tight junction_Homo sapiens_hsa045301.16629243
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15668883
39FoxO signaling pathway_Homo sapiens_hsa040681.06161423
40Vascular smooth muscle contraction_Homo sapiens_hsa042701.04237118
41Gastric acid secretion_Homo sapiens_hsa049710.99871746
42GnRH signaling pathway_Homo sapiens_hsa049120.98602855
43Fatty acid metabolism_Homo sapiens_hsa012120.95392508
44Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94622535
45Arginine biosynthesis_Homo sapiens_hsa002200.93389632
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.85972591
47Focal adhesion_Homo sapiens_hsa045100.84654178
48mTOR signaling pathway_Homo sapiens_hsa041500.83486505
49HIF-1 signaling pathway_Homo sapiens_hsa040660.70962122
50VEGF signaling pathway_Homo sapiens_hsa043700.68404068
51MAPK signaling pathway_Homo sapiens_hsa040100.67729708
52Huntingtons disease_Homo sapiens_hsa050160.65932519
53Renin secretion_Homo sapiens_hsa049240.63831272
54Fatty acid biosynthesis_Homo sapiens_hsa000610.59505028
55PPAR signaling pathway_Homo sapiens_hsa033200.50749510
56Platelet activation_Homo sapiens_hsa046110.50585560
57Type II diabetes mellitus_Homo sapiens_hsa049300.49375779
58Insulin secretion_Homo sapiens_hsa049110.48725459
59beta-Alanine metabolism_Homo sapiens_hsa004100.48089869
60Butanoate metabolism_Homo sapiens_hsa006500.45231240
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36213446
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.35884337
63Nitrogen metabolism_Homo sapiens_hsa009100.34209805
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32056615
65Long-term depression_Homo sapiens_hsa047300.30889500
66Sulfur metabolism_Homo sapiens_hsa009200.29513700
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29210753
68Renal cell carcinoma_Homo sapiens_hsa052110.28864264
69Amoebiasis_Homo sapiens_hsa051460.27108433
70Adherens junction_Homo sapiens_hsa045200.26407431
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24181636
72Proteoglycans in cancer_Homo sapiens_hsa052050.23681913
73Cholinergic synapse_Homo sapiens_hsa047250.21668592
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21017640
75Regulation of autophagy_Homo sapiens_hsa041400.18835507
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17761439
77Peroxisome_Homo sapiens_hsa041460.17533585
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17330873
79Long-term potentiation_Homo sapiens_hsa047200.15608497
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.14987181
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14748992
82Circadian entrainment_Homo sapiens_hsa047130.13525299
83Purine metabolism_Homo sapiens_hsa002300.13379335
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.13182366
85Prolactin signaling pathway_Homo sapiens_hsa049170.12487936
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12317814
87Sulfur relay system_Homo sapiens_hsa041220.11899248
88Metabolic pathways_Homo sapiens_hsa011000.10984216
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10619300
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.10342726
91Phenylalanine metabolism_Homo sapiens_hsa003600.08994894
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.07889591
93Tryptophan metabolism_Homo sapiens_hsa003800.07137026
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06327510
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.05260555
96ABC transporters_Homo sapiens_hsa020100.04906762
97Pancreatic secretion_Homo sapiens_hsa049720.04238744
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.03796529
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.02961034
100Bile secretion_Homo sapiens_hsa049760.02192770

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »