LRRC31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular glucuronidation (GO:0052695)6.81265613
2uronic acid metabolic process (GO:0006063)6.58018850
3glucuronate metabolic process (GO:0019585)6.58018850
4intestinal absorption (GO:0050892)6.08905335
5epoxygenase P450 pathway (GO:0019373)5.74489835
6exogenous drug catabolic process (GO:0042738)5.47267470
7sulfate transmembrane transport (GO:1902358)5.39548088
8bile acid and bile salt transport (GO:0015721)5.23479468
9ribosomal small subunit assembly (GO:0000028)5.15540238
10drug catabolic process (GO:0042737)5.09886514
11angiotensin maturation (GO:0002003)4.97709399
12regulation of bile acid biosynthetic process (GO:0070857)4.95043307
13regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.75687016
14flavonoid metabolic process (GO:0009812)4.70442763
15maturation of SSU-rRNA (GO:0030490)4.67496342
16drug metabolic process (GO:0017144)4.57419186
17ribosomal large subunit biogenesis (GO:0042273)4.54803468
18mitotic metaphase plate congression (GO:0007080)4.48440043
19DNA replication initiation (GO:0006270)4.47860712
20fat-soluble vitamin biosynthetic process (GO:0042362)4.44126444
21sulfate transport (GO:0008272)4.40082897
22urea metabolic process (GO:0019627)4.31462849
23transcytosis (GO:0045056)4.27217817
24chromatin remodeling at centromere (GO:0031055)4.26451148
25telomere maintenance via semi-conservative replication (GO:0032201)4.26189858
26DNA strand elongation involved in DNA replication (GO:0006271)4.25519565
27ethanol oxidation (GO:0006069)4.16648457
28DNA replication checkpoint (GO:0000076)4.16499432
29CENP-A containing nucleosome assembly (GO:0034080)4.15693028
30bile acid metabolic process (GO:0008206)4.14284050
31DNA strand elongation (GO:0022616)4.13379213
32regulation of double-strand break repair via homologous recombination (GO:0010569)4.12407194
33urea cycle (GO:0000050)4.05993469
34regulation of guanylate cyclase activity (GO:0031282)4.03798734
35regulation of systemic arterial blood pressure by hormone (GO:0001990)4.02608292
36regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.02608292
37endocrine process (GO:0050886)4.02608292
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.02411315
39telomere maintenance via telomere lengthening (GO:0010833)4.00070965
40metaphase plate congression (GO:0051310)3.99253854
41viral transcription (GO:0019083)3.95286820
42telomere maintenance via recombination (GO:0000722)3.89667299
43maintenance of gastrointestinal epithelium (GO:0030277)3.87632553
44regulation of nuclear cell cycle DNA replication (GO:0033262)3.85120941
45calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.83029659
46translational termination (GO:0006415)3.82229871
47kinetochore organization (GO:0051383)3.81311025
48bundle of His cell to Purkinje myocyte communication (GO:0086069)3.79453927
49ethanol metabolic process (GO:0006067)3.78810647
50nitrogen cycle metabolic process (GO:0071941)3.74719378
51kinetochore assembly (GO:0051382)3.74250418
52regulation of cholesterol homeostasis (GO:2000188)3.74216890
53protein K6-linked ubiquitination (GO:0085020)3.73125218
54meiotic chromosome segregation (GO:0045132)3.73034218
55hormone catabolic process (GO:0042447)3.72696446
56ribosomal small subunit biogenesis (GO:0042274)3.72188664
57NADH metabolic process (GO:0006734)3.71768338
58drug transmembrane transport (GO:0006855)3.68610856
59nucleobase biosynthetic process (GO:0046112)3.68179319
60protein localization to kinetochore (GO:0034501)3.67990128
61phenylpropanoid metabolic process (GO:0009698)3.67173143
62lipoprotein transport (GO:0042953)3.66573514
63mitotic recombination (GO:0006312)3.65407246
64RNA-dependent DNA replication (GO:0006278)3.61099644
65regulation of helicase activity (GO:0051095)3.60832696
66purine nucleobase biosynthetic process (GO:0009113)3.60706861
67intestinal epithelial cell development (GO:0060576)3.56718814
68establishment of chromosome localization (GO:0051303)3.56644066
69telomere maintenance via telomerase (GO:0007004)3.56356316
70regulation of triglyceride catabolic process (GO:0010896)3.55256719
71arginine metabolic process (GO:0006525)3.50688384
72mitotic sister chromatid segregation (GO:0000070)3.50125049
73nucleotide-excision repair, DNA gap filling (GO:0006297)3.46796516
74ribonucleoprotein complex biogenesis (GO:0022613)3.46211696
75replicative senescence (GO:0090399)3.45268533
76O-glycan processing (GO:0016266)3.45010203
77IMP biosynthetic process (GO:0006188)3.44957700
78glycosylceramide metabolic process (GO:0006677)3.44774691
79regulation of systemic arterial blood pressure (GO:0003073)3.44586557
80regulation of respiratory burst (GO:0060263)3.43779647
81rRNA modification (GO:0000154)3.43210128
82maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.42995574
83alkaloid metabolic process (GO:0009820)3.42445003
84translational elongation (GO:0006414)3.42366551
85vitamin transmembrane transport (GO:0035461)3.42030128
86pseudouridine synthesis (GO:0001522)3.38452073
87DNA replication-independent nucleosome assembly (GO:0006336)3.38087490
88DNA replication-independent nucleosome organization (GO:0034724)3.38087490
89termination of RNA polymerase III transcription (GO:0006386)3.34689111
90transcription elongation from RNA polymerase III promoter (GO:0006385)3.34689111
91telomere maintenance (GO:0000723)3.33459793
92intra-S DNA damage checkpoint (GO:0031573)3.32363244
93replication fork processing (GO:0031297)3.31967046
94primary alcohol catabolic process (GO:0034310)3.31696845
95telomere organization (GO:0032200)3.31234576
96regulation of vitamin metabolic process (GO:0030656)3.29463709
97renal system process involved in regulation of blood volume (GO:0001977)3.29186700
98translational initiation (GO:0006413)3.27760102
99sphingomyelin metabolic process (GO:0006684)3.27369514
100DNA deamination (GO:0045006)3.26718932
101drug transport (GO:0015893)3.25942154
102SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22139066
103transepithelial transport (GO:0070633)3.20471871
104positive regulation of cell size (GO:0045793)3.20145150
105sulfur compound transport (GO:0072348)3.19914319
106histone exchange (GO:0043486)3.19407086
107omega-hydroxylase P450 pathway (GO:0097267)3.18260863
108formation of translation preinitiation complex (GO:0001731)3.17575182
109pyrimidine-containing compound transmembrane transport (GO:0072531)3.17525700
110ribosome assembly (GO:0042255)3.16465276
111transcription-coupled nucleotide-excision repair (GO:0006283)3.15522636
112protein localization to chromosome, centromeric region (GO:0071459)3.13631206
113phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.13144114
114nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.13134864
115cotranslational protein targeting to membrane (GO:0006613)3.12257608
116mitotic chromosome condensation (GO:0007076)3.11957761
117transcription from RNA polymerase I promoter (GO:0006360)3.11859410
118DNA unwinding involved in DNA replication (GO:0006268)3.11104336
119protein targeting to ER (GO:0045047)3.10102018
120sperm capacitation (GO:0048240)3.08812486
121somatic hypermutation of immunoglobulin genes (GO:0016446)3.08630854
122somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08630854
123rRNA processing (GO:0006364)3.08437296
124negative regulation of neurotransmitter secretion (GO:0046929)3.07600375
125macroautophagy (GO:0016236)3.06297155
126epithelial structure maintenance (GO:0010669)3.05997531
127cellular protein complex disassembly (GO:0043624)3.05454272
128nuclear pore organization (GO:0006999)3.05141562
129glutamine family amino acid biosynthetic process (GO:0009084)3.05028263
130phospholipid efflux (GO:0033700)3.04512007
131attachment of spindle microtubules to kinetochore (GO:0008608)3.03863243
132ribosome biogenesis (GO:0042254)3.03778896
133digestive system process (GO:0022600)3.03378772
134DNA double-strand break processing (GO:0000729)3.03227149
135regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01662840
136viral life cycle (GO:0019058)3.01032486
137cellular zinc ion homeostasis (GO:0006882)2.98902101
138rRNA metabolic process (GO:0016072)2.97942713
139primary alcohol metabolic process (GO:0034308)2.97155503
140fructose metabolic process (GO:0006000)2.96626155
141mitotic nuclear envelope disassembly (GO:0007077)2.95961906
142desmosome organization (GO:0002934)2.95116131
143multicellular organismal water homeostasis (GO:0050891)2.95030698
144histone H4-K12 acetylation (GO:0043983)2.94321368
145positive regulation of lipid catabolic process (GO:0050996)2.92094281
146positive regulation of guanylate cyclase activity (GO:0031284)2.91720591
147regulation of chemokine secretion (GO:0090196)2.91470042
148glycerol metabolic process (GO:0006071)2.91384678
149inner cell mass cell proliferation (GO:0001833)2.90888770
150establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90699322
151interferon-gamma secretion (GO:0072643)2.90423769
152sister chromatid segregation (GO:0000819)2.90280078
153DNA replication-dependent nucleosome organization (GO:0034723)2.89624031
154DNA replication-dependent nucleosome assembly (GO:0006335)2.89624031
155bile acid biosynthetic process (GO:0006699)2.89269507
156auditory receptor cell differentiation (GO:0042491)2.88667607
157protein localization to endoplasmic reticulum (GO:0070972)2.87718877
158regulation of protein glycosylation (GO:0060049)2.87702071
159tRNA methylation (GO:0030488)2.87069536
160sodium ion homeostasis (GO:0055078)2.86469909
161rRNA methylation (GO:0031167)2.85924573
162regulation of sister chromatid cohesion (GO:0007063)2.85164952
163receptor guanylyl cyclase signaling pathway (GO:0007168)2.84555000
164mismatch repair (GO:0006298)2.84213962
165retinal metabolic process (GO:0042574)2.82837153
166determination of adult lifespan (GO:0008340)2.82184177
167DNA catabolic process, exonucleolytic (GO:0000738)2.81961250
168androgen metabolic process (GO:0008209)2.81242780
169amino-acid betaine metabolic process (GO:0006577)2.80626131
170DNA synthesis involved in DNA repair (GO:0000731)2.80584401
171IMP metabolic process (GO:0046040)2.80542946
172DNA geometric change (GO:0032392)2.80387746
173DNA duplex unwinding (GO:0032508)2.79651443
174xenobiotic metabolic process (GO:0006805)2.79540331
175heme transport (GO:0015886)2.79505561
176alditol metabolic process (GO:0019400)2.78978547
177folic acid-containing compound biosynthetic process (GO:0009396)2.78020470
178transcription initiation from RNA polymerase I promoter (GO:0006361)2.77174076
179termination of RNA polymerase I transcription (GO:0006363)2.76775536
180translation (GO:0006412)2.76326374
181oligosaccharide biosynthetic process (GO:0009312)2.75441034
182DNA replication (GO:0006260)2.75071027
183bicarbonate transport (GO:0015701)2.74678612
184resolution of meiotic recombination intermediates (GO:0000712)2.74344283
185regulation of intracellular pH (GO:0051453)2.74060270
186positive regulation of fatty acid beta-oxidation (GO:0032000)2.71789069
187very-low-density lipoprotein particle assembly (GO:0034379)2.70225282
188negative regulation of cholesterol transport (GO:0032375)2.70058617
189negative regulation of sterol transport (GO:0032372)2.70058617
190digestion (GO:0007586)2.69392544
191glycosphingolipid catabolic process (GO:0046479)2.68680920
192oxidative demethylation (GO:0070989)2.67135559
193purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.67064977
1943-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.67064977
195fatty acid catabolic process (GO:0009062)2.65828489
196vitamin transport (GO:0051180)2.60415561
197citrulline biosynthetic process (GO:0019240)2.59898904
198glycolipid catabolic process (GO:0019377)2.59182471
199nucleotide-sugar biosynthetic process (GO:0009226)2.58633715

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.67510747
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.31105098
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.09406549
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.98976072
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.87184726
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.64710213
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.51588204
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21219375
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.19866599
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.13392184
11ESR1_21235772_ChIP-Seq_MCF-7_Human3.13309103
12ESR1_20079471_ChIP-ChIP_T-47D_Human3.07154811
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.06771734
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06714089
15SOX2_27498859_Chip-Seq_STOMACH_Mouse3.01883921
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.94034430
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.84932120
18GATA4_25053715_ChIP-Seq_YYC3_Human2.71418191
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.68950858
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.67471695
21GATA6_25053715_ChIP-Seq_YYC3_Human2.66202121
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.65967061
23NANOG_18555785_ChIP-Seq_MESCs_Mouse2.64696808
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.62365494
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62091047
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53836770
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46135863
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43558737
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.35973529
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.33014926
31FOXO3_23340844_ChIP-Seq_DLD1_Human2.29479859
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29112340
33* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.24888454
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.24134524
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.24134524
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.24134524
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21622008
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21431860
39ETS1_20019798_ChIP-Seq_JURKAT_Human2.17367928
40AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.15849139
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15335798
42SOX2_20726797_ChIP-Seq_SW620_Human2.14988030
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.14210674
44ZNF217_24962896_ChIP-Seq_MCF-7_Human2.14023755
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10621446
46AR_21909140_ChIP-Seq_LNCAP_Human2.07863074
47FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.06956659
48TP63_17297297_ChIP-ChIP_HaCaT_Human2.06911596
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.06334628
50CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05174092
51E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03868805
52SALL1_21062744_ChIP-ChIP_HESCs_Human2.02972158
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02839164
54IRF8_22096565_ChIP-ChIP_GC-B_Human2.01614331
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01493115
56PPAR_26484153_Chip-Seq_NCI-H1993_Human2.01159076
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.99710672
58VDR_23849224_ChIP-Seq_CD4+_Human1.93020658
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.91456026
60NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.88927812
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88000766
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.87482978
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.84195349
64FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.82607708
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82265669
66CLOCK_20551151_ChIP-Seq_293T_Human1.76502012
67XRN2_22483619_ChIP-Seq_HELA_Human1.74625559
68TCF4_18268006_ChIP-ChIP_LS174T_Human1.74423624
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.74135434
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.74135434
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73009880
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.68362785
73TCF3_18692474_ChIP-Seq_MEFs_Mouse1.67867431
74GATA3_24758297_ChIP-Seq_MCF-7_Human1.66787576
75YY1_21170310_ChIP-Seq_MESCs_Mouse1.65358760
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64933284
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63859307
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63164208
79DCP1A_22483619_ChIP-Seq_HELA_Human1.60907016
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.60477086
81FOXP3_21729870_ChIP-Seq_TREG_Human1.60467006
82NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.60382673
83CDX2_22108803_ChIP-Seq_LS180_Human1.59282338
84* FOXA1_25552417_ChIP-Seq_VCAP_Human1.58847138
85TTF2_22483619_ChIP-Seq_HELA_Human1.57864996
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56523590
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49872145
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.46919839
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.45845385
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.45590689
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.45191135
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43402766
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43380760
94ELK1_19687146_ChIP-ChIP_HELA_Human1.42764913
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42643404
96FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.42016952
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40154437
98SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39931561
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39866343
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34832617
101GATA1_22025678_ChIP-Seq_K562_Human1.34730792
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33818473
103IRF1_19129219_ChIP-ChIP_H3396_Human1.33709296
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.33348101
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33298787
106AHR_22903824_ChIP-Seq_MCF-7_Human1.31029568
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28323051
108HNFA_21074721_ChIP-Seq_CACO-2_Human1.27855171
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27571532
110SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.26578753
111HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26297975
112CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.25446538
113GABP_19822575_ChIP-Seq_HepG2_Human1.23398836
114RACK7_27058665_Chip-Seq_MCF-7_Human1.23130428
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23069136
116TRIM28_21343339_ChIP-Seq_HEK293_Human1.22475737
117CHD1_26751641_Chip-Seq_LNCaP_Human1.22324295
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22077254
119FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20990753
120HNF4A_19822575_ChIP-Seq_HepG2_Human1.20498730
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20173119
122NANOG_18692474_ChIP-Seq_MEFs_Mouse1.19456112
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.19038449
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18875884
125SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18731491
126GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.17739676
127TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16292523
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14980954
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14666481
130THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14632260
131SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14268385
132STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13729321
133FOXA2_19822575_ChIP-Seq_HepG2_Human1.13672480
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12066863
135GATA6_21074721_ChIP-Seq_CACO-2_Human1.12013084
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11372630
137RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11246174
138ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10582689
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08411754
140ELF5_23300383_ChIP-Seq_T47D_Human1.07709980
141NFE2_27457419_Chip-Seq_LIVER_Mouse1.07643104
142PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07579580
143CJUN_26792858_Chip-Seq_BT549_Human1.06492239
144SMAD_19615063_ChIP-ChIP_OVARY_Human1.05904677
145KLF5_25053715_ChIP-Seq_YYC3_Human1.05291074
146NANOG_18692474_ChIP-Seq_MESCs_Mouse1.04944248
147SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04562249
148NANOG_21062744_ChIP-ChIP_HESCs_Human1.03238404
149NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00150707
150ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99899798
151SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99498814
152FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99422507
153SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98915128
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98287396
155ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97895803
156KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97542939
157KDM5A_27292631_Chip-Seq_BREAST_Human0.96692161
158POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95934922
159KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94238296
160SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94142592
161PHF8_20622853_ChIP-Seq_HELA_Human0.94119866
162CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93955411
163KAP1_27257070_Chip-Seq_ESCs_Mouse0.93532368
164P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93363602
165RBPJ_21746931_ChIP-Seq_IB4_Human0.92544092
166OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91849363
167EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91221178
168FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90811386
169SOX2_18555785_Chip-Seq_ESCs_Mouse0.90490294
170AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90350013
171ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89722627
172FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89346071
173CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88646375
174BCAT_22108803_ChIP-Seq_LS180_Human0.87427432
175TP63_23658742_ChIP-Seq_EP156T_Human0.86696099
176RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86686838
177CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86443294
178MYC_18940864_ChIP-ChIP_HL60_Human0.86189375
179SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85732858
180E2F1_18555785_Chip-Seq_ESCs_Mouse0.85382435
181ESRRB_18555785_Chip-Seq_ESCs_Mouse0.85254186
182SMAD1_18555785_Chip-Seq_ESCs_Mouse0.84943348
183EZH2_27294783_Chip-Seq_NPCs_Mouse0.84741433
184HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84732961
185SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84263924
186STAT3_18555785_Chip-Seq_ESCs_Mouse0.84157585
187TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83692428
188NFYA_21822215_ChIP-Seq_K562_Human0.83507746
189ZFX_18555785_Chip-Seq_ESCs_Mouse0.82973469
190CEBPB_22108803_ChIP-Seq_LS180_Human0.82938286
191SOX17_20123909_ChIP-Seq_XEN_Mouse0.82734233
192POU5F1_16518401_ChIP-PET_MESCs_Mouse0.80985438
193ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80917113
194CIITA_25753668_ChIP-Seq_RAJI_Human0.80452383

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.53625690
2MP0002139_abnormal_hepatobiliary_system6.03132020
3MP0005085_abnormal_gallbladder_physiolo4.97100094
4MP0003693_abnormal_embryo_hatching4.87339215
5MP0005365_abnormal_bile_salt4.56054746
6MP0010094_abnormal_chromosome_stability4.22795641
7MP0001666_abnormal_nutrient_absorption3.89180036
8MP0003111_abnormal_nucleus_morphology3.69792671
9MP0003183_abnormal_peptide_metabolism3.65243262
10MP0008057_abnormal_DNA_replication3.64679490
11MP0004957_abnormal_blastocyst_morpholog3.62614838
12MP0008058_abnormal_DNA_repair3.22426862
13MP0003077_abnormal_cell_cycle3.07005691
14MP0003868_abnormal_feces_composition2.89330077
15MP0010352_gastrointestinal_tract_polyps2.83344453
16MP0005670_abnormal_white_adipose2.75595478
17MP0003718_maternal_effect2.72668953
18MP0000490_abnormal_crypts_of2.63716439
19MP0003252_abnormal_bile_duct2.56291932
20MP0008875_abnormal_xenobiotic_pharmacok2.55692563
21MP0003315_abnormal_perineum_morphology2.35555293
22MP0003806_abnormal_nucleotide_metabolis2.34847764
23MP0002277_abnormal_respiratory_mucosa2.32833237
24MP0008007_abnormal_cellular_replicative2.25338369
25MP0002396_abnormal_hematopoietic_system2.24328935
26MP0004147_increased_porphyrin_level2.20098776
27MP0003136_yellow_coat_color2.19327667
28MP0002166_altered_tumor_susceptibility2.12381689
29MP0003941_abnormal_skin_development2.10415566
30MP0008932_abnormal_embryonic_tissue1.99425397
31MP0001664_abnormal_digestion1.95312858
32MP0002138_abnormal_hepatobiliary_system1.95059162
33MP0009840_abnormal_foam_cell1.93884793
34MP0000566_synostosis1.91287665
35MP0002254_reproductive_system_inflammat1.86875086
36MP0002132_abnormal_respiratory_system1.82368482
37MP0004264_abnormal_extraembryonic_tissu1.81798486
38MP0003191_abnormal_cellular_cholesterol1.81704843
39MP0003786_premature_aging1.79837852
40MP0004043_abnormal_pH_regulation1.79379187
41MP0003123_paternal_imprinting1.67193413
42MP0003787_abnormal_imprinting1.61315291
43MP0003950_abnormal_plasma_membrane1.61287278
44MP0000350_abnormal_cell_proliferation1.60105819
45MP0010234_abnormal_vibrissa_follicle1.56355121
46MP0009379_abnormal_foot_pigmentation1.55740182
47MP0001485_abnormal_pinna_reflex1.53993184
48MP0005332_abnormal_amino_acid1.53513450
49MP0010329_abnormal_lipoprotein_level1.53346396
50MP0008877_abnormal_DNA_methylation1.53075987
51MP0008004_abnormal_stomach_pH1.51200048
52MP0000538_abnormal_urinary_bladder1.50350844
53MP0002006_tumorigenesis1.49145406
54MP0009643_abnormal_urine_homeostasis1.48098090
55MP0001765_abnormal_ion_homeostasis1.44836651
56MP0000537_abnormal_urethra_morphology1.44118202
57MP0002160_abnormal_reproductive_system1.42363151
58MP0001188_hyperpigmentation1.41941511
59MP0006292_abnormal_olfactory_placode1.37956514
60MP0000609_abnormal_liver_physiology1.37257392
61MP0003186_abnormal_redox_activity1.37207974
62MP0000462_abnormal_digestive_system1.37149719
63MP0005636_abnormal_mineral_homeostasis1.35646023
64MP0001764_abnormal_homeostasis1.34765917
65MP0001730_embryonic_growth_arrest1.30756553
66MP0005389_reproductive_system_phenotype1.28811547
67MP0002876_abnormal_thyroid_physiology1.28663701
68MP0010155_abnormal_intestine_physiology1.28322502
69MP0001119_abnormal_female_reproductive1.27937004
70MP0002210_abnormal_sex_determination1.26055944
71MP0005380_embryogenesis_phenotype1.24443102
72MP0001672_abnormal_embryogenesis/_devel1.24443102
73MP0009697_abnormal_copulation1.24040234
74MP0001919_abnormal_reproductive_system1.23509970
75MP0002136_abnormal_kidney_physiology1.21867503
76MP0002796_impaired_skin_barrier1.21590217
77MP0004133_heterotaxia1.19620923
78MP0003890_abnormal_embryonic-extraembry1.19410689
79MP0000477_abnormal_intestine_morphology1.18791301
80MP0002163_abnormal_gland_morphology1.17842512
81MP0005381_digestive/alimentary_phenotyp1.17434266
82MP0001873_stomach_inflammation1.17261400
83MP0002118_abnormal_lipid_homeostasis1.16312443
84MP0001145_abnormal_male_reproductive1.10408340
85MP0002653_abnormal_ependyma_morphology1.09995826
86MP0002009_preneoplasia1.09060129
87MP0000653_abnormal_sex_gland1.08886991
88MP0001501_abnormal_sleep_pattern1.07781106
89MP0005501_abnormal_skin_physiology1.07582153
90MP0005166_decreased_susceptibility_to1.06902973
91MP0000470_abnormal_stomach_morphology1.04688569
92MP0003763_abnormal_thymus_physiology1.03661650
93MP0000313_abnormal_cell_death1.03610724
94MP0010307_abnormal_tumor_latency1.02873462
95MP0002019_abnormal_tumor_incidence1.01545120
96MP0002085_abnormal_embryonic_tissue1.00305288
97MP0005075_abnormal_melanosome_morpholog0.98580207
98MP0001697_abnormal_embryo_size0.97621980
99MP0002086_abnormal_extraembryonic_tissu0.96590130
100MP0000516_abnormal_urinary_system0.95020009
101MP0005367_renal/urinary_system_phenotyp0.95020009
102MP0003566_abnormal_cell_adhesion0.92256996
103MP0003984_embryonic_growth_retardation0.91755001
104MP0005666_abnormal_adipose_tissue0.89399001
105MP0002088_abnormal_embryonic_growth/wei0.88942238
106MP0001929_abnormal_gametogenesis0.88373002
107MP0005319_abnormal_enzyme/_coenzyme0.87956448
108MP0001756_abnormal_urination0.87311816
109MP0005310_abnormal_salivary_gland0.86897117
110MP0000858_altered_metastatic_potential0.86471984
111MP0003936_abnormal_reproductive_system0.85286621
112MP0005409_darkened_coat_color0.84295012
113MP0000613_abnormal_salivary_gland0.84267161
114MP0003195_calcinosis0.84141244
115MP0002080_prenatal_lethality0.82040961
116MP0005174_abnormal_tail_pigmentation0.81112270
117MP0002084_abnormal_developmental_patter0.79657683
118MP0002098_abnormal_vibrissa_morphology0.79499634
119MP0005395_other_phenotype0.79115185
120MP0002148_abnormal_hypersensitivity_rea0.78780962
121MP0001502_abnormal_circadian_rhythm0.77226077
122MP0003121_genomic_imprinting0.76870212
123MP0000467_abnormal_esophagus_morphology0.76610432
124MP0004019_abnormal_vitamin_homeostasis0.76151488
125MP0004782_abnormal_surfactant_physiolog0.75612618
126MP0000569_abnormal_digit_pigmentation0.75400651
127MP0001293_anophthalmia0.75221144
128MP0005451_abnormal_body_composition0.74068637
129MP0002060_abnormal_skin_morphology0.73670503
130MP0008961_abnormal_basal_metabolism0.72846136
131MP0006054_spinal_hemorrhage0.72697526
132MP0000465_gastrointestinal_hemorrhage0.71946690
133MP0003045_fibrosis0.71392175
134MP0001845_abnormal_inflammatory_respons0.71152532
135MP0000627_abnormal_mammary_gland0.70516948
136MP0003283_abnormal_digestive_organ0.70452887
137MP0001216_abnormal_epidermal_layer0.70246481
138MP0005408_hypopigmentation0.69877648
139MP0003866_abnormal_defecation0.69860326
140MP0005266_abnormal_metabolism0.69848233
141MP0005584_abnormal_enzyme/coenzyme_acti0.69277003
142MP0003699_abnormal_female_reproductive0.68827046
143MP0002111_abnormal_tail_morphology0.67527740
144MP0005083_abnormal_biliary_tract0.67294645
145MP0003453_abnormal_keratinocyte_physiol0.65668823
146MP0000678_abnormal_parathyroid_gland0.64968034
147MP0003879_abnormal_hair_cell0.64456519
148MP0001663_abnormal_digestive_system0.64323083
149MP0008872_abnormal_physiological_respon0.62554401
150MP0006138_congestive_heart_failure0.59724220
151MP0000230_abnormal_systemic_arterial0.59617315
152MP0009642_abnormal_blood_homeostasis0.58743338
153MP0005647_abnormal_sex_gland0.58123139
154MP0005187_abnormal_penis_morphology0.56738610
155MP0009785_altered_susceptibility_to0.56607907
156MP0001881_abnormal_mammary_gland0.56450620
157MP0002168_other_aberrant_phenotype0.53971733
158MP0005535_abnormal_body_temperature0.52438223
159MP0002971_abnormal_brown_adipose0.52003853
160MP0000598_abnormal_liver_morphology0.50895464
161MP0003953_abnormal_hormone_level0.50773468
162MP0008469_abnormal_protein_level0.50674540
163MP0001346_abnormal_lacrimal_gland0.50255655
164MP0004947_skin_inflammation0.46288958
165MP0005165_increased_susceptibility_to0.45044710
166MP0000427_abnormal_hair_cycle0.43826675

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)6.75827720
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.37355588
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.99793405
4Chromsome breakage (HP:0040012)5.82406180
5Chromosomal breakage induced by crosslinking agents (HP:0003221)5.53432457
6Conjugated hyperbilirubinemia (HP:0002908)4.80787673
7Decreased circulating renin level (HP:0003351)4.77811916
8Hypobetalipoproteinemia (HP:0003563)4.58487004
9Fat malabsorption (HP:0002630)4.53332808
10Metabolic alkalosis (HP:0200114)4.50349831
11Intrahepatic cholestasis (HP:0001406)4.44262217
12Birth length less than 3rd percentile (HP:0003561)4.37799065
13Abnormality of renin-angiotensin system (HP:0000847)4.37568608
14Abnormality of the preputium (HP:0100587)4.35454722
15Malnutrition (HP:0004395)4.35341026
16Abnormality of proline metabolism (HP:0010907)4.24537893
17Hydroxyprolinuria (HP:0003080)4.24537893
18Reticulocytopenia (HP:0001896)4.21130038
19Breast hypoplasia (HP:0003187)4.08447757
20Azoospermia (HP:0000027)3.99086367
21Flat acetabular roof (HP:0003180)3.95755654
22Abnormality of chloride homeostasis (HP:0011422)3.90096245
23Alkalosis (HP:0001948)3.86376204
24Right ventricular cardiomyopathy (HP:0011663)3.85704674
25Abnormality of chromosome stability (HP:0003220)3.75862871
26Chronic diarrhea (HP:0002028)3.62505683
27Meckel diverticulum (HP:0002245)3.57523349
28Abnormal hemoglobin (HP:0011902)3.56517581
29Hyperaldosteronism (HP:0000859)3.44308700
30Abnormality of the ileum (HP:0001549)3.38590934
31Aplasia/Hypoplasia of the uvula (HP:0010293)3.37749886
32Absent thumb (HP:0009777)3.37190332
33Duplicated collecting system (HP:0000081)3.36501546
34Absent radius (HP:0003974)3.33281711
35Oral leukoplakia (HP:0002745)3.21813819
36Abnormality of vitamin metabolism (HP:0100508)3.21159578
37Abdominal distention (HP:0003270)3.18567151
38Absent forearm bone (HP:0003953)3.16527905
39Aplasia involving forearm bones (HP:0009822)3.16527905
40Hyperammonemia (HP:0001987)3.14165281
41Abnormality of the vitamin B12 metabolism (HP:0004341)3.13415186
42Abnormality of the labia minora (HP:0012880)3.11782206
43Aplastic anemia (HP:0001915)3.09978576
44Hyperglycinuria (HP:0003108)2.96444481
45Abnormality of the renal collecting system (HP:0004742)2.88777208
46Abnormal tarsal ossification (HP:0008369)2.87972370
47Steatorrhea (HP:0002570)2.87835724
48Abnormality of vitamin B metabolism (HP:0004340)2.87474622
49Duodenal stenosis (HP:0100867)2.87375676
50Small intestinal stenosis (HP:0012848)2.87375676
51Systemic lupus erythematosus (HP:0002725)2.85876560
52Colon cancer (HP:0003003)2.85865593
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.84369691
54Hemorrhage of the eye (HP:0011885)2.75935130
55Agnosia (HP:0010524)2.74637522
56Poikiloderma (HP:0001029)2.72277718
57Patellar aplasia (HP:0006443)2.69930852
58Abnormality of cells of the erythroid lineage (HP:0012130)2.69016217
59Widely patent fontanelles and sutures (HP:0004492)2.67876239
60Pigmentary retinal degeneration (HP:0001146)2.67668754
61Impulsivity (HP:0100710)2.64736701
62Bone marrow hypocellularity (HP:0005528)2.64238961
63Vascular calcification (HP:0004934)2.62381298
64Myelodysplasia (HP:0002863)2.62362375
65Flat capital femoral epiphysis (HP:0003370)2.60518201
66Type I transferrin isoform profile (HP:0003642)2.59213586
67Hyponatremia (HP:0002902)2.54911793
68Hyperkalemia (HP:0002153)2.54395824
69Prostate neoplasm (HP:0100787)2.52126037
70Nausea (HP:0002018)2.51601673
71Clubbing of toes (HP:0100760)2.50642231
72Aplasia/Hypoplasia of the patella (HP:0006498)2.49914823
73Abnormality of serine family amino acid metabolism (HP:0010894)2.48924090
74Abnormality of glycine metabolism (HP:0010895)2.48924090
75Xanthomatosis (HP:0000991)2.48653988
76Stenosis of the external auditory canal (HP:0000402)2.48572056
77Petechiae (HP:0000967)2.47288357
78Abnormality of urine glucose concentration (HP:0011016)2.47012308
79Glycosuria (HP:0003076)2.47012308
80Rough bone trabeculation (HP:0100670)2.46121398
81Abnormality of DNA repair (HP:0003254)2.45873703
82Abnormality of potassium homeostasis (HP:0011042)2.45645507
83Hypokalemia (HP:0002900)2.45339071
84Ectopic kidney (HP:0000086)2.45280226
85Pallor (HP:0000980)2.44914635
86Abnormal number of erythroid precursors (HP:0012131)2.44865851
87Triphalangeal thumb (HP:0001199)2.44816879
88Glomerulonephritis (HP:0000099)2.43958038
89Increased hepatocellular lipid droplets (HP:0006565)2.41808263
90Proximal tubulopathy (HP:0000114)2.41507701
91Hypolipoproteinemia (HP:0010981)2.38589128
92Trismus (HP:0000211)2.37134219
93Macrocytic anemia (HP:0001972)2.36452190
94Curly hair (HP:0002212)2.34475956
95Acanthocytosis (HP:0001927)2.34023225
96Complement deficiency (HP:0004431)2.32822070
97Shawl scrotum (HP:0000049)2.29836127
98Selective tooth agenesis (HP:0001592)2.28524469
99Abnormality of the duodenum (HP:0002246)2.27879357
100Cardiovascular calcification (HP:0011915)2.27563470
101Metabolic acidosis (HP:0001942)2.27447033
102Deep venous thrombosis (HP:0002625)2.27183000
103Nephritis (HP:0000123)2.25752277
104Alopecia of scalp (HP:0002293)2.24999715
105Supernumerary spleens (HP:0009799)2.24643783
106Exertional dyspnea (HP:0002875)2.22356877
107Amniotic constriction ring (HP:0009775)2.22264661
108Abnormality of placental membranes (HP:0011409)2.22264661
109Cone-rod dystrophy (HP:0000548)2.21395239
110Cerebral hypomyelination (HP:0006808)2.21323015
111Prolonged partial thromboplastin time (HP:0003645)2.20260659
112Neonatal short-limb short stature (HP:0008921)2.20243318
113Thin bony cortex (HP:0002753)2.20214523
114Sparse eyelashes (HP:0000653)2.20036936
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19740573
116Respiratory difficulties (HP:0002880)2.18926999
11711 pairs of ribs (HP:0000878)2.17333084
118Dehydration (HP:0001944)2.16911185
119Villous atrophy (HP:0011473)2.16889793
120Abnormality of small intestinal villus morphology (HP:0011472)2.16889793
121Sloping forehead (HP:0000340)2.16202805
122Abnormality of aromatic amino acid family metabolism (HP:0004338)2.15371883
123Chronic bronchitis (HP:0004469)2.15119880
124Horseshoe kidney (HP:0000085)2.14861759
125Ileus (HP:0002595)2.14810802
126Ependymoma (HP:0002888)2.14717541
127Rhabdomyosarcoma (HP:0002859)2.13135374
128Tracheoesophageal fistula (HP:0002575)2.12823048
129Rickets (HP:0002748)2.12650297
130Lip pit (HP:0100267)2.12291943
131Carpal bone hypoplasia (HP:0001498)2.12196900
132Pulmonary fibrosis (HP:0002206)2.12100092
133Abnormality of the nasal septum (HP:0000419)2.11683458
134Medulloblastoma (HP:0002885)2.10503473
135Short thumb (HP:0009778)2.09989971
136Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07167315
137Abnormality of the carotid arteries (HP:0005344)2.05834907
138Lipid accumulation in hepatocytes (HP:0006561)2.03805365
139Premature graying of hair (HP:0002216)2.03167154
140Potter facies (HP:0002009)2.02636798
141Facial shape deformation (HP:0011334)2.02636798
142Generalized aminoaciduria (HP:0002909)2.01598296
143Congenital sensorineural hearing impairment (HP:0008527)2.01505661
144Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01278511
145Dicarboxylic aciduria (HP:0003215)2.01278511
146Abnormality of complement system (HP:0005339)2.00702938
147Breast carcinoma (HP:0003002)2.00232093
148Abnormality of cochlea (HP:0000375)1.99745829
149Premature loss of primary teeth (HP:0006323)1.99525440
150Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.98542070
151Focal segmental glomerulosclerosis (HP:0000097)1.98471176
152Congenital, generalized hypertrichosis (HP:0004540)1.97702880
153Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97107918
154Bifid scrotum (HP:0000048)1.96585147
155Rectal fistula (HP:0100590)1.96175295
156Rectovaginal fistula (HP:0000143)1.96175295
157Aplasia/hypoplasia of the humerus (HP:0006507)1.93739859
158Abnormal trabecular bone morphology (HP:0100671)1.92816331
159Abnormality of pyrimidine metabolism (HP:0004353)1.90181202
160Megaloblastic anemia (HP:0001889)1.87555687
161Abnormal cartilage morphology (HP:0002763)1.87537608
162Abnormality of the distal phalanx of the thumb (HP:0009617)1.87484952
163Cheilitis (HP:0100825)1.87399849
164Abnormality of nucleobase metabolism (HP:0010932)1.86293484
165Flattened epiphyses (HP:0003071)1.86230340
166Duplication of thumb phalanx (HP:0009942)1.85723626
167Alveolar cell carcinoma (HP:0006519)1.85586186
168Abnormality of purine metabolism (HP:0004352)1.85556371
169Abnormal biliary tract morphology (HP:0012440)1.84299925
170Microvesicular hepatic steatosis (HP:0001414)1.84262432
171Tongue fasciculations (HP:0001308)1.83489906
172Hypoglycemic coma (HP:0001325)1.82634313
173Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81715177
174Posterior subcapsular cataract (HP:0007787)1.81683171
175Aplasia/hypoplasia of the uterus (HP:0008684)1.80641696
176Glomerulosclerosis (HP:0000096)1.80138895
177Abnormal spermatogenesis (HP:0008669)1.79883807
178Seborrheic dermatitis (HP:0001051)1.79265612
179Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79198436
180Abnormality of sodium homeostasis (HP:0010931)1.78527331
181Adrenal overactivity (HP:0002717)1.78467683
182Enlarged epiphyses (HP:0010580)1.78274725
183Visceral angiomatosis (HP:0100761)1.78225680
184Spinal muscular atrophy (HP:0007269)1.77664566
185Biliary tract neoplasm (HP:0100574)1.77394532
186Aplasia/Hypoplasia involving the musculature (HP:0001460)1.77053576
187Neoplasm of the colon (HP:0100273)1.76706282
188Degeneration of anterior horn cells (HP:0002398)1.76469390
189Abnormality of the anterior horn cell (HP:0006802)1.76469390
190Hypoplasia of the radius (HP:0002984)1.76047015
191Hypergonadotropic hypogonadism (HP:0000815)1.75943098
192Anal stenosis (HP:0002025)1.75516349
193Long foot (HP:0001833)1.73746028
194Pustule (HP:0200039)1.73022636
195Premature ovarian failure (HP:0008209)1.71593627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK23.81776368
2AKT33.26232838
3MST43.16344857
4WEE12.95289131
5STK392.80904655
6TTK2.78418443
7RIPK12.67482032
8CDC72.65595559
9OXSR12.59195824
10EIF2AK12.58340509
11BUB12.54945004
12PBK2.45187718
13EPHA22.41636351
14SRPK12.29281311
15PLK42.25186360
16STK38L2.25167031
17PIK3CA2.18360575
18NEK12.17924442
19STK162.15971974
20FER1.97518648
21ZAK1.92861779
22ERN11.89690327
23EIF2AK31.83247046
24PLK11.82111409
25AURKB1.70059042
26FRK1.66702038
27IRAK31.66093816
28CDK71.64474842
29MAP3K121.62424015
30RPS6KB21.60461069
31VRK11.60317866
32ACVR1B1.55469531
33NEK21.53712595
34TSSK61.51436070
35NME11.49313867
36NUAK11.46671608
37PASK1.45279908
38TLK11.43346639
39EIF2AK21.43149038
40BRSK21.42698608
41CDK81.41202071
42MAP3K101.35536819
43ATR1.34977661
44STK101.31466249
45CHEK21.29143356
46MST1R1.26780743
47TAOK11.26327321
48PDK21.23411205
49MKNK11.21887183
50ABL21.16595958
51PLK31.15983556
52BCR1.15622039
53CASK1.11261527
54LATS11.08406616
55MKNK21.08049272
56PIK3CG1.03304898
57MAP3K21.01788114
58AURKA0.99375887
59CDK120.97698591
60NME20.93397668
61FGFR40.87552843
62TYK20.83445474
63SIK30.82650296
64MYLK0.81001588
65STK40.80364483
66SCYL20.80164938
67NEK60.79221065
68STK30.77139377
69PRKAA20.76921897
70BMPR20.76595452
71MATK0.75076783
72TGFBR10.75065532
73TEC0.75049418
74CHEK10.72862436
75PDPK10.71762356
76GRK10.71441796
77BMPR1B0.70060232
78ATM0.69183337
79MAP3K80.67698465
80NEK90.65508412
81ERBB30.65371245
82PRKCI0.64217473
83PTK60.64188992
84MAP3K30.63418376
85MAPKAPK30.62242672
86TRIB30.62238414
87TRPM70.61423693
88TESK10.60021070
89MAP2K20.59981623
90MELK0.59951196
91EPHA30.59428744
92PRKG20.58811139
93LATS20.56403151
94BRAF0.53624253
95PIM10.53395475
96YES10.53272209
97CDK20.52642491
98CSNK2A10.52637211
99CSNK2A20.52395053
100ERBB20.51052730
101TBK10.50944803
102MAPK110.50828808
103CAMK2D0.50668712
104TRIM280.50558855
105MAP3K110.49775832
106PDK10.49611767
107PAK40.49509477
108BRSK10.48834327
109MAP2K60.48174748
110PKN20.46147043
111WNK30.44117112
112MET0.44064259
113PIM20.43711504
114CDK60.40503940
115PRKCQ0.39981267
116PTK20.39736971
117WNK40.38576210
118MAP2K10.38277513
119CDK10.38114131
120IRAK40.37913686
121IRAK20.37783276
122DYRK30.37299713
123PAK10.36636440
124CDK40.36521806
125PAK30.35332120
126ITK0.35262469
127IGF1R0.35256471
128IRAK10.34933513
129PRKCZ0.33990231
130STK380.33853543
131PDK40.33026318
132PDK30.33026318
133PRKCA0.32762093
134STK240.32035107
135DYRK20.31009128
136CAMK2G0.30890095
137MAP3K140.30352721
138LRRK20.29727538
139SMG10.29413880
140FGFR30.29114408
141MAP4K10.28850493
142MAP3K10.28187819
143NLK0.27629406
144DYRK1B0.27603328
145PRKAA10.26838721
146EEF2K0.26153717
147DMPK0.25971355
148CSNK1A10.25835843
149ERBB40.25618146
150PDGFRB0.25532727
151CSNK1E0.25485778
152PRKACG0.25186885
153GRK60.24966923
154TNK20.24550082
155TXK0.24432997
156EPHB10.23545136
157CHUK0.23126342
158IKBKB0.22834539
159SRC0.22690834
160MTOR0.20363596
161BRD40.20138162
162CAMK1D0.19291935
163BTK0.18180853
164CCNB10.17925463
165EPHB20.17692095
166MAPKAPK20.17366175

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.40923606
2Caffeine metabolism_Homo sapiens_hsa002324.31686393
3Mismatch repair_Homo sapiens_hsa034304.10329271
4Ribosome_Homo sapiens_hsa030103.99592650
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.68924442
6Homologous recombination_Homo sapiens_hsa034403.56629904
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.50631727
8RNA polymerase_Homo sapiens_hsa030203.39414277
9Sulfur metabolism_Homo sapiens_hsa009203.14094471
10Fanconi anemia pathway_Homo sapiens_hsa034603.13192160
11Retinol metabolism_Homo sapiens_hsa008302.85453237
12Non-homologous end-joining_Homo sapiens_hsa034502.81475395
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.74215518
14Base excision repair_Homo sapiens_hsa034102.68616456
15Nucleotide excision repair_Homo sapiens_hsa034202.67141584
16Fat digestion and absorption_Homo sapiens_hsa049752.52262633
17One carbon pool by folate_Homo sapiens_hsa006702.50479168
18Chemical carcinogenesis_Homo sapiens_hsa052042.48470942
19Pyrimidine metabolism_Homo sapiens_hsa002402.45552913
20RNA transport_Homo sapiens_hsa030132.44578265
21Proteasome_Homo sapiens_hsa030502.41671259
22Steroid hormone biosynthesis_Homo sapiens_hsa001402.40687035
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.37308800
24Spliceosome_Homo sapiens_hsa030402.27059071
25Cell cycle_Homo sapiens_hsa041102.21650949
26Arginine biosynthesis_Homo sapiens_hsa002202.17469140
27Starch and sucrose metabolism_Homo sapiens_hsa005002.10721418
28Primary bile acid biosynthesis_Homo sapiens_hsa001202.03709211
29Nitrogen metabolism_Homo sapiens_hsa009102.00135830
30PPAR signaling pathway_Homo sapiens_hsa033201.94397828
31Bile secretion_Homo sapiens_hsa049761.91793700
32Fatty acid degradation_Homo sapiens_hsa000711.91176283
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90160585
34Basal transcription factors_Homo sapiens_hsa030221.85897563
35RNA degradation_Homo sapiens_hsa030181.76769008
36Tryptophan metabolism_Homo sapiens_hsa003801.75426487
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73473706
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.66665438
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62707097
40p53 signaling pathway_Homo sapiens_hsa041151.58163764
41Purine metabolism_Homo sapiens_hsa002301.50513544
42Phenylalanine metabolism_Homo sapiens_hsa003601.39391151
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.36382883
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29232593
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29059172
46mRNA surveillance pathway_Homo sapiens_hsa030151.22700935
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18826209
48Butanoate metabolism_Homo sapiens_hsa006501.15879710
49Renin-angiotensin system_Homo sapiens_hsa046141.12600818
50Tyrosine metabolism_Homo sapiens_hsa003501.09146545
51Fructose and mannose metabolism_Homo sapiens_hsa000511.08718929
52Arachidonic acid metabolism_Homo sapiens_hsa005901.07947379
53Glutathione metabolism_Homo sapiens_hsa004801.06950233
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04362237
55Folate biosynthesis_Homo sapiens_hsa007900.99186573
56Peroxisome_Homo sapiens_hsa041460.95219908
57Huntingtons disease_Homo sapiens_hsa050160.94981731
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.92384853
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91263150
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90630974
61Complement and coagulation cascades_Homo sapiens_hsa046100.90563158
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87603537
63Glycerolipid metabolism_Homo sapiens_hsa005610.87154523
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.83454000
65Other glycan degradation_Homo sapiens_hsa005110.82476793
66Propanoate metabolism_Homo sapiens_hsa006400.82466453
67Mineral absorption_Homo sapiens_hsa049780.81442463
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77302334
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75569789
70Oxidative phosphorylation_Homo sapiens_hsa001900.73804156
71Fatty acid metabolism_Homo sapiens_hsa012120.73159401
72Arginine and proline metabolism_Homo sapiens_hsa003300.71952889
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.70103042
74Epstein-Barr virus infection_Homo sapiens_hsa051690.69016741
75Herpes simplex infection_Homo sapiens_hsa051680.66846178
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.65989342
77ABC transporters_Homo sapiens_hsa020100.64189880
78Parkinsons disease_Homo sapiens_hsa050120.63017599
79Systemic lupus erythematosus_Homo sapiens_hsa053220.62506844
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62147135
81Thyroid cancer_Homo sapiens_hsa052160.61275878
82Vitamin B6 metabolism_Homo sapiens_hsa007500.58912091
83Fatty acid biosynthesis_Homo sapiens_hsa000610.58864205
84Pancreatic secretion_Homo sapiens_hsa049720.57553599
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56531624
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55872917
87Galactose metabolism_Homo sapiens_hsa000520.54551108
88Insulin resistance_Homo sapiens_hsa049310.54523654
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53264398
90Hematopoietic cell lineage_Homo sapiens_hsa046400.52665296
91Metabolic pathways_Homo sapiens_hsa011000.52029961
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.50618135
93Viral carcinogenesis_Homo sapiens_hsa052030.50193958
94Legionellosis_Homo sapiens_hsa051340.50130527
95Pyruvate metabolism_Homo sapiens_hsa006200.48472056
96Circadian rhythm_Homo sapiens_hsa047100.46565950
97Pentose phosphate pathway_Homo sapiens_hsa000300.46494250
98Influenza A_Homo sapiens_hsa051640.45275160
99beta-Alanine metabolism_Homo sapiens_hsa004100.44892557
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44346310
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44165908
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43522185
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.42378257
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40553550
105Histidine metabolism_Homo sapiens_hsa003400.40464954
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40167228
107Linoleic acid metabolism_Homo sapiens_hsa005910.40016194
108Biosynthesis of amino acids_Homo sapiens_hsa012300.39214587
109TGF-beta signaling pathway_Homo sapiens_hsa043500.39077756
110Vitamin digestion and absorption_Homo sapiens_hsa049770.38901043
111Sphingolipid metabolism_Homo sapiens_hsa006000.38351283
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37027054
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36678173
114Hippo signaling pathway_Homo sapiens_hsa043900.36332180
115Oocyte meiosis_Homo sapiens_hsa041140.35891273
116Adherens junction_Homo sapiens_hsa045200.35643766
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35514119
118Lysine degradation_Homo sapiens_hsa003100.35023328
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33496286
120Selenocompound metabolism_Homo sapiens_hsa004500.32849039
121Notch signaling pathway_Homo sapiens_hsa043300.32696933
122Small cell lung cancer_Homo sapiens_hsa052220.32438320
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32224994
124Tight junction_Homo sapiens_hsa045300.32077512
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31790124
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30533255
127MicroRNAs in cancer_Homo sapiens_hsa052060.29764472
128N-Glycan biosynthesis_Homo sapiens_hsa005100.29435171
129Apoptosis_Homo sapiens_hsa042100.29433033
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27947912
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26602120
132Alzheimers disease_Homo sapiens_hsa050100.26204647
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24700559
134Staphylococcus aureus infection_Homo sapiens_hsa051500.23606947
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23290581
136Ether lipid metabolism_Homo sapiens_hsa005650.23004510
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21761177
138Basal cell carcinoma_Homo sapiens_hsa052170.20903078
139Carbon metabolism_Homo sapiens_hsa012000.20875539
140Glucagon signaling pathway_Homo sapiens_hsa049220.19703474
141Sulfur relay system_Homo sapiens_hsa041220.19699167
142Hepatitis C_Homo sapiens_hsa051600.19651864
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.19338616
144Protein digestion and absorption_Homo sapiens_hsa049740.19162697
145NF-kappa B signaling pathway_Homo sapiens_hsa040640.16501884
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.16108595
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14957774
148AMPK signaling pathway_Homo sapiens_hsa041520.14943153
149Thyroid hormone synthesis_Homo sapiens_hsa049180.14120522
1502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.14112996
151Melanoma_Homo sapiens_hsa052180.14082640
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14014153
153Asthma_Homo sapiens_hsa053100.11901670
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.07284026
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.07107479
156TNF signaling pathway_Homo sapiens_hsa046680.06607514
157Cocaine addiction_Homo sapiens_hsa050300.05652924
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05046106
159Inositol phosphate metabolism_Homo sapiens_hsa005620.04149250
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.02575250
161Allograft rejection_Homo sapiens_hsa053300.02187077
162Prostate cancer_Homo sapiens_hsa052150.01293258
163Amphetamine addiction_Homo sapiens_hsa050310.00278964
164Aldosterone synthesis and secretion_Homo sapiens_hsa049250.00252442
165Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0041445

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