LRRC34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.88663663
2binding of sperm to zona pellucida (GO:0007339)9.60399757
3sperm motility (GO:0030317)9.41839592
4plasma membrane fusion (GO:0045026)9.41361522
5axonemal dynein complex assembly (GO:0070286)9.26653758
6reproduction (GO:0000003)8.95727670
7male meiosis (GO:0007140)8.23535243
8epithelial cilium movement (GO:0003351)8.19737152
9cilium movement (GO:0003341)7.92495989
10acrosome reaction (GO:0007340)7.63014928
11piRNA metabolic process (GO:0034587)7.48961591
12spermatid development (GO:0007286)7.41083583
13motile cilium assembly (GO:0044458)7.35923398
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.27209535
15synaptonemal complex assembly (GO:0007130)7.10140430
16synaptonemal complex organization (GO:0070193)6.99774840
17single fertilization (GO:0007338)6.81960659
18regulation of cilium movement (GO:0003352)6.75732790
19sperm capacitation (GO:0048240)6.42514871
20fertilization (GO:0009566)5.60983611
21ventricular system development (GO:0021591)5.36367087
22chromosome organization involved in meiosis (GO:0070192)5.34098109
23DNA methylation involved in gamete generation (GO:0043046)5.01130729
24protein-cofactor linkage (GO:0018065)4.98762360
25microtubule severing (GO:0051013)4.95037291
26meiotic nuclear division (GO:0007126)4.94416058
27behavioral response to nicotine (GO:0035095)4.81653651
28spermatid nucleus differentiation (GO:0007289)4.77400623
29spermatogenesis (GO:0007283)4.75741209
30male gamete generation (GO:0048232)4.74763491
31microtubule depolymerization (GO:0007019)4.73665452
32cell recognition (GO:0008037)4.69103539
33cellular process involved in reproduction in multicellular organism (GO:0022412)4.64713124
34male meiosis I (GO:0007141)4.52047251
35germ cell development (GO:0007281)4.46406995
36gamete generation (GO:0007276)4.39473688
37chaperone-mediated protein complex assembly (GO:0051131)4.25579675
38monoubiquitinated protein deubiquitination (GO:0035520)4.23595929
39protein polyglutamylation (GO:0018095)4.19129808
40regulation of centriole replication (GO:0046599)4.15368356
41nuclear pore complex assembly (GO:0051292)4.06914790
42regulation of microtubule-based movement (GO:0060632)3.98340964
43negative regulation of inclusion body assembly (GO:0090084)3.77718409
44organic cation transport (GO:0015695)3.74382510
45meiosis I (GO:0007127)3.70529489
46DNA deamination (GO:0045006)3.67497711
47intraciliary transport (GO:0042073)3.66185465
48synapsis (GO:0007129)3.61003891
49nuclear pore organization (GO:0006999)3.60732864
50protein neddylation (GO:0045116)3.60653797
51calcium ion-dependent exocytosis (GO:0017156)3.54534188
52DNA replication-dependent nucleosome organization (GO:0034723)3.46599619
53DNA replication-dependent nucleosome assembly (GO:0006335)3.46599619
54regulation of inclusion body assembly (GO:0090083)3.46411139
55fucose catabolic process (GO:0019317)3.43681095
56L-fucose metabolic process (GO:0042354)3.43681095
57L-fucose catabolic process (GO:0042355)3.43681095
58detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.43322351
59rRNA catabolic process (GO:0016075)3.42528924
60multicellular organismal reproductive process (GO:0048609)3.42303066
61centriole replication (GO:0007099)3.39632846
62peptidyl-lysine dimethylation (GO:0018027)3.36963982
63nonmotile primary cilium assembly (GO:0035058)3.35212360
64protein K6-linked ubiquitination (GO:0085020)3.34881897
65negative regulation of organelle assembly (GO:1902116)3.34775429
66gene silencing by RNA (GO:0031047)3.32451511
67cellular ketone body metabolic process (GO:0046950)3.31658764
68meiotic cell cycle process (GO:1903046)3.28940319
69response to pheromone (GO:0019236)3.27388769
70platelet dense granule organization (GO:0060155)3.24502635
71centriole assembly (GO:0098534)3.23483165
72axoneme assembly (GO:0035082)3.20140278
73histone H3-K9 methylation (GO:0051567)3.19726575
74meiotic cell cycle (GO:0051321)3.18512702
75behavioral response to ethanol (GO:0048149)3.16410120
76protein localization to cilium (GO:0061512)3.15462295
77maturation of 5.8S rRNA (GO:0000460)3.14291242
78pore complex assembly (GO:0046931)3.10299376
79mitochondrial respiratory chain complex I assembly (GO:0032981)3.09979062
80NADH dehydrogenase complex assembly (GO:0010257)3.09979062
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09979062
82detection of light stimulus involved in visual perception (GO:0050908)3.07602394
83detection of light stimulus involved in sensory perception (GO:0050962)3.07602394
84histone exchange (GO:0043486)3.06439545
85replication fork processing (GO:0031297)3.04571731
86photoreceptor cell maintenance (GO:0045494)3.04395042
87ubiquinone biosynthetic process (GO:0006744)3.01084670
88microtubule-based movement (GO:0007018)2.98870966
89seminiferous tubule development (GO:0072520)2.98144445
90genitalia morphogenesis (GO:0035112)2.97376812
91ketone body metabolic process (GO:1902224)2.96266505
92cilium organization (GO:0044782)2.95696655
93regulation of spindle checkpoint (GO:0090231)2.95378058
94protein complex biogenesis (GO:0070271)2.93668144
95histone H3-K9 modification (GO:0061647)2.93511847
96retinal cone cell development (GO:0046549)2.91854034
97sulfation (GO:0051923)2.90877915
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.90284176
99mitochondrial respiratory chain complex assembly (GO:0033108)2.89258614
100protein import into peroxisome matrix (GO:0016558)2.86773545
101chromosome condensation (GO:0030261)2.86666678
102ubiquinone metabolic process (GO:0006743)2.84903552
103cornea development in camera-type eye (GO:0061303)2.83289278
104negative regulation of T cell differentiation in thymus (GO:0033085)2.82460427
105tryptophan catabolic process (GO:0006569)2.81951334
106indole-containing compound catabolic process (GO:0042436)2.81951334
107indolalkylamine catabolic process (GO:0046218)2.81951334
108preassembly of GPI anchor in ER membrane (GO:0016254)2.79692252
109single strand break repair (GO:0000012)2.78300573
110cellular component assembly involved in morphogenesis (GO:0010927)2.78158080
111cilium assembly (GO:0042384)2.78151847
112regulation of rhodopsin mediated signaling pathway (GO:0022400)2.77312808
113kynurenine metabolic process (GO:0070189)2.75807187
114positive regulation of macrophage activation (GO:0043032)2.75420875
115nucleoside diphosphate phosphorylation (GO:0006165)2.75135522
116DNA packaging (GO:0006323)2.74981289
117nucleus organization (GO:0006997)2.74959459
118somatic hypermutation of immunoglobulin genes (GO:0016446)2.74649579
119somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74649579
120mitotic sister chromatid cohesion (GO:0007064)2.74053976
121establishment of protein localization to mitochondrial membrane (GO:0090151)2.73146523
122neural tube formation (GO:0001841)2.71162558
123water-soluble vitamin biosynthetic process (GO:0042364)2.70672759
124negative regulation of DNA repair (GO:0045738)2.69339792
125regulation of meiosis I (GO:0060631)2.69030728
126multicellular organismal development (GO:0007275)2.69016578
127indolalkylamine metabolic process (GO:0006586)2.68531446
128GTP biosynthetic process (GO:0006183)2.68164677
129negative regulation of telomere maintenance (GO:0032205)2.65713724
130negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64601359
131blastocyst development (GO:0001824)2.63418792
132photoreceptor cell development (GO:0042461)2.63144664
133microtubule polymerization or depolymerization (GO:0031109)2.62595063
134negative regulation of DNA-dependent DNA replication (GO:2000104)2.62467957
135protein K11-linked deubiquitination (GO:0035871)2.61212910
136cilium morphogenesis (GO:0060271)2.61199308
137neuronal action potential (GO:0019228)2.60951943
138respiratory chain complex IV assembly (GO:0008535)2.60948080
139rhodopsin mediated signaling pathway (GO:0016056)2.60536827
140pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.60048429
141UTP biosynthetic process (GO:0006228)2.59970201
142glycerol ether metabolic process (GO:0006662)2.58603937
143transmission of nerve impulse (GO:0019226)2.57333069
144regulation of centrosome cycle (GO:0046605)2.56953195
145exogenous drug catabolic process (GO:0042738)2.56004807
146RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55213275
147tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55213275
148energy coupled proton transport, down electrochemical gradient (GO:0015985)2.53500789
149ATP synthesis coupled proton transport (GO:0015986)2.53500789
150tryptophan metabolic process (GO:0006568)2.52476023
151gamma-aminobutyric acid transport (GO:0015812)2.49695643
152cAMP catabolic process (GO:0006198)2.48214720
153mitochondrial RNA metabolic process (GO:0000959)2.46735999
154cell proliferation in forebrain (GO:0021846)2.46128651
155GPI anchor metabolic process (GO:0006505)2.44915149
156left/right pattern formation (GO:0060972)2.43397080
157intracellular protein transmembrane import (GO:0044743)2.43080556
158positive regulation of fatty acid transport (GO:2000193)2.42476557
159regulation of gene silencing by RNA (GO:0060966)2.42394639
160regulation of posttranscriptional gene silencing (GO:0060147)2.42394639
161regulation of gene silencing by miRNA (GO:0060964)2.42394639
162mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.41769466
163microtubule bundle formation (GO:0001578)2.38494901
164maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.36959359
165determination of left/right symmetry (GO:0007368)2.36626816
166smoothened signaling pathway (GO:0007224)2.36516329
167rRNA modification (GO:0000154)2.36453264
168adaptation of signaling pathway (GO:0023058)2.35064085
169spinal cord motor neuron differentiation (GO:0021522)2.34959421
170cell wall macromolecule metabolic process (GO:0044036)12.6061600
171cell wall macromolecule catabolic process (GO:0016998)12.6061600
172fusion of sperm to egg plasma membrane (GO:0007342)12.4334340
173cilium or flagellum-dependent cell motility (GO:0001539)12.2061860
174acrosome assembly (GO:0001675)12.1356742
175multicellular organism reproduction (GO:0032504)11.2236015
176sperm-egg recognition (GO:0035036)11.0677479

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.55111814
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.58439682
3E2F7_22180533_ChIP-Seq_HELA_Human3.67522446
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.52328453
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.38287367
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14556299
7GBX2_23144817_ChIP-Seq_PC3_Human2.74501582
8IGF1R_20145208_ChIP-Seq_DFB_Human2.55207688
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53674671
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47283941
11EWS_26573619_Chip-Seq_HEK293_Human2.43307445
12TAF15_26573619_Chip-Seq_HEK293_Human2.40835850
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.39146854
14FUS_26573619_Chip-Seq_HEK293_Human2.38543341
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38337664
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.37984939
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.23435484
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.21039791
19CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.15505008
20KAP1_22055183_ChIP-Seq_ESCs_Mouse2.11663597
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.08225164
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07658123
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.03548965
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.01379146
25P300_19829295_ChIP-Seq_ESCs_Human1.97394032
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.90840669
27ER_23166858_ChIP-Seq_MCF-7_Human1.88081665
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83992831
29RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.81980274
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79877310
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.77295021
32* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74956177
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69824612
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.67326744
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.66957686
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.65668816
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63486091
38TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62331628
39BCAT_22108803_ChIP-Seq_LS180_Human1.59346562
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.56867903
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55942763
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54387924
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52105329
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.52046338
45IRF1_19129219_ChIP-ChIP_H3396_Human1.50479590
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50255399
47GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49303977
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48197339
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47510589
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.46896347
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46521568
52EZH2_22144423_ChIP-Seq_EOC_Human1.44722847
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44547870
54ZNF274_21170338_ChIP-Seq_K562_Hela1.44451796
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43294785
56SMAD4_21799915_ChIP-Seq_A2780_Human1.42993780
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42792409
58STAT3_23295773_ChIP-Seq_U87_Human1.42595132
59AR_25329375_ChIP-Seq_VCAP_Human1.41366999
60VDR_22108803_ChIP-Seq_LS180_Human1.41130246
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.40696278
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40007010
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38980083
64RNF2_27304074_Chip-Seq_NSC_Mouse1.37807919
65AR_21572438_ChIP-Seq_LNCaP_Human1.36589443
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36408736
67TP53_22573176_ChIP-Seq_HFKS_Human1.36275539
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35902399
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34340619
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.34340619
71GATA3_21867929_ChIP-Seq_CD8_Mouse1.34163353
72KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33573712
73REST_21632747_ChIP-Seq_MESCs_Mouse1.33565388
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31177121
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31082885
76EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30027226
77MYC_18940864_ChIP-ChIP_HL60_Human1.27952475
78TCF4_22108803_ChIP-Seq_LS180_Human1.27502881
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26929479
80ELK4_26923725_Chip-Seq_MESODERM_Mouse1.26735868
81SOX2_19829295_ChIP-Seq_ESCs_Human1.26385313
82NANOG_19829295_ChIP-Seq_ESCs_Human1.26385313
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26037668
84FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25995501
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.25452126
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24957279
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24957279
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24764867
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.24640142
90LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.24039256
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.23643647
92TCF4_23295773_ChIP-Seq_U87_Human1.22578349
93AR_20517297_ChIP-Seq_VCAP_Human1.22160706
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.21801975
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.21597473
96STAT1_17558387_ChIP-Seq_HELA_Human1.20789829
97* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19799071
98RUNX2_22187159_ChIP-Seq_PCA_Human1.19714716
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18313586
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.17072347
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16880689
102KLF4_18555785_Chip-Seq_ESCs_Mouse1.16698640
103GATA3_21867929_ChIP-Seq_TH1_Mouse1.16595902
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15800904
105NCOR_22424771_ChIP-Seq_293T_Human1.13303969
106MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13110159
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.12586257
108P300_18555785_Chip-Seq_ESCs_Mouse1.12143092
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.11963706
110ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11253436
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.10846042
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10809956
113ESRRB_18555785_Chip-Seq_ESCs_Mouse1.10455561
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09800544
115SOX2_22085726_ChIP-Seq_NPCs_Mouse1.09357571
116SMAD4_21741376_ChIP-Seq_EPCs_Human1.08570624
117VDR_23849224_ChIP-Seq_CD4+_Human1.08296424
118GATA3_21878914_ChIP-Seq_MCF-7_Human1.07977221
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07528413
120POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07362413
121KDM2B_26808549_Chip-Seq_REH_Human1.07200422
122ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05897758
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05390101
124RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05256072
125RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05091781
126ELK1_19687146_ChIP-ChIP_HELA_Human1.05081877
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04962388
128CMYC_18555785_Chip-Seq_ESCs_Mouse1.04878866
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04876136
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04732195
131* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04423899
132MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04285581
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04093219
134MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02043450
135CTCF_18555785_Chip-Seq_ESCs_Mouse1.01980148
136WDR5_24793694_ChIP-Seq_LNCAP_Human1.01936652
137STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01791781
138SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01050928
139STAT3_18555785_Chip-Seq_ESCs_Mouse1.00243370
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00203196
141STAT3_18555785_ChIP-Seq_MESCs_Mouse0.99746759
142CBP_20019798_ChIP-Seq_JUKART_Human0.99690828
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99690828
144OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99332866
145* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.99045840
146* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98905445
147RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98222350
148P53_22387025_ChIP-Seq_ESCs_Mouse0.98122777
149AR_21909140_ChIP-Seq_LNCAP_Human0.98085384
150* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97391561
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96290342
152CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95741729
153SPI1_26923725_Chip-Seq_HPCs_Mouse0.95637383
154SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95234335
155MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95041379
156AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94100907
157RARA_24833708_ChIP-Seq_LIVER_Mouse0.93839899
158HOXB7_26014856_ChIP-Seq_BT474_Human0.93550216
159EED_16625203_ChIP-ChIP_MESCs_Mouse0.92984920
160CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92900220
161CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92206232
162SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89915534
163POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89318451
164* CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88180987
165CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87939193
166ZFX_18555785_Chip-Seq_ESCs_Mouse0.87348549
167SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86584489
168E2F1_18555785_Chip-Seq_ESCs_Mouse0.85925925
169ESET_19884257_ChIP-Seq_ESCs_Mouse0.85559547
170PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84002493
171ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83904309
172RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83739599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.32708574
2MP0003698_abnormal_male_reproductive5.24752545
3MP0008877_abnormal_DNA_methylation5.05146591
4MP0001929_abnormal_gametogenesis5.00354532
5MP0008057_abnormal_DNA_replication3.79292015
6MP0002210_abnormal_sex_determination3.72535807
7MP0005623_abnormal_meninges_morphology3.29045250
8MP0001145_abnormal_male_reproductive3.23719854
9MP0008058_abnormal_DNA_repair3.16430916
10MP0002161_abnormal_fertility/fecundity2.90176995
11MP0010094_abnormal_chromosome_stability2.85309555
12MP0000653_abnormal_sex_gland2.82294062
13MP0006292_abnormal_olfactory_placode2.59811553
14MP0005551_abnormal_eye_electrophysiolog2.47659426
15MP0008875_abnormal_xenobiotic_pharmacok2.24608739
16MP0000569_abnormal_digit_pigmentation2.16242899
17MP0004147_increased_porphyrin_level2.14028958
18MP0001968_abnormal_touch/_nociception2.13521243
19MP0002837_dystrophic_cardiac_calcinosis2.05479595
20MP0001986_abnormal_taste_sensitivity2.01904676
21MP0003880_abnormal_central_pattern2.01894556
22MP0005410_abnormal_fertilization12.0662614
23MP0009046_muscle_twitch1.94487012
24MP0004885_abnormal_endolymph1.91854434
25MP0003111_abnormal_nucleus_morphology1.91099666
26MP0002736_abnormal_nociception_after1.86817554
27MP0006276_abnormal_autonomic_nervous1.81446596
28MP0008789_abnormal_olfactory_epithelium1.79216385
29MP0004133_heterotaxia1.78723486
30MP0004742_abnormal_vestibular_system1.73567602
31MP0003195_calcinosis1.73326829
32MP0005646_abnormal_pituitary_gland1.73084302
33MP0009745_abnormal_behavioral_response1.72346368
34MP0004957_abnormal_blastocyst_morpholog1.71012433
35MP0001485_abnormal_pinna_reflex1.70311003
36MP0002876_abnormal_thyroid_physiology1.70198739
37MP0002272_abnormal_nervous_system1.69104885
38MP0002282_abnormal_trachea_morphology1.66308443
39MP0002277_abnormal_respiratory_mucosa1.65727976
40MP0002160_abnormal_reproductive_system1.65633167
41MP0003077_abnormal_cell_cycle1.65392171
42MP0001529_abnormal_vocalization1.63951226
43MP0002638_abnormal_pupillary_reflex1.57824595
44MP0008007_abnormal_cellular_replicative1.55482907
45MP0000631_abnormal_neuroendocrine_gland1.55432092
46MP0002938_white_spotting1.51366257
47MP0004142_abnormal_muscle_tone1.50913987
48MP0003693_abnormal_embryo_hatching1.38455142
49MP0009379_abnormal_foot_pigmentation1.38387377
50MP0005174_abnormal_tail_pigmentation1.38092975
51MP0002234_abnormal_pharynx_morphology1.35311085
52MP0010307_abnormal_tumor_latency1.34098526
53MP0001730_embryonic_growth_arrest1.30148287
54MP0004043_abnormal_pH_regulation1.29505372
55MP0004233_abnormal_muscle_weight1.29332246
56MP0000372_irregular_coat_pigmentation1.27021172
57MP0002735_abnormal_chemical_nociception1.24111695
58MP0003786_premature_aging1.23620195
59MP0005645_abnormal_hypothalamus_physiol1.22481945
60MP0001486_abnormal_startle_reflex1.20203149
61MP0005195_abnormal_posterior_eye1.19509430
62MP0005394_taste/olfaction_phenotype1.19132705
63MP0005499_abnormal_olfactory_system1.19132705
64MP0002572_abnormal_emotion/affect_behav1.18651175
65MP0003806_abnormal_nucleotide_metabolis1.17350167
66MP0001501_abnormal_sleep_pattern1.16962560
67MP0000026_abnormal_inner_ear1.15084428
68MP0001346_abnormal_lacrimal_gland1.15054907
69MP0002557_abnormal_social/conspecific_i1.14648138
70MP0001293_anophthalmia1.13576792
71MP0003646_muscle_fatigue1.13500584
72MP0002064_seizures1.12132329
73MP0005084_abnormal_gallbladder_morpholo1.11162435
74MP0003011_delayed_dark_adaptation1.09549548
75MP0002067_abnormal_sensory_capabilities1.08760335
76MP0005389_reproductive_system_phenotype1.07787496
77MP0005670_abnormal_white_adipose1.07707414
78MP0001963_abnormal_hearing_physiology1.05700648
79MP0004145_abnormal_muscle_electrophysio1.03914456
80MP0000778_abnormal_nervous_system1.03264757
81MP0004215_abnormal_myocardial_fiber1.03172761
82MP0003635_abnormal_synaptic_transmissio1.01890053
83MP0001984_abnormal_olfaction1.01852006
84MP0002084_abnormal_developmental_patter1.00850570
85MP0002734_abnormal_mechanical_nocicepti1.00201810
86MP0003136_yellow_coat_color0.98206444
87MP0001970_abnormal_pain_threshold0.97943120
88MP0002752_abnormal_somatic_nervous0.97846764
89MP0010386_abnormal_urinary_bladder0.96619611
90MP0005647_abnormal_sex_gland0.95523463
91MP0008932_abnormal_embryonic_tissue0.95327312
92MP0002733_abnormal_thermal_nociception0.93579251
93MP0002095_abnormal_skin_pigmentation0.93440400
94MP0002229_neurodegeneration0.93381594
95MP0000049_abnormal_middle_ear0.92432654
96MP0003950_abnormal_plasma_membrane0.91172621
97MP0003252_abnormal_bile_duct0.90739106
98MP0002085_abnormal_embryonic_tissue0.90470880
99MP0000566_synostosis0.86797811
100MP0002751_abnormal_autonomic_nervous0.86757654
101MP0005380_embryogenesis_phenotype0.86279705
102MP0001672_abnormal_embryogenesis/_devel0.86279705
103MP0002063_abnormal_learning/memory/cond0.84709255
104MP0004924_abnormal_behavior0.83271241
105MP0005386_behavior/neurological_phenoty0.83271241
106MP0001697_abnormal_embryo_size0.82865109
107MP0003315_abnormal_perineum_morphology0.82316193
108MP0001119_abnormal_female_reproductive0.81881676
109MP0005187_abnormal_penis_morphology0.81683711
110MP0001764_abnormal_homeostasis0.80117724
111MP0000350_abnormal_cell_proliferation0.78942043
112MP0003699_abnormal_female_reproductive0.77780748
113MP0006054_spinal_hemorrhage0.76167933
114MP0001324_abnormal_eye_pigmentation0.76056217
115MP0003984_embryonic_growth_retardation0.74695690
116MP0003123_paternal_imprinting0.72506800
117MP0000313_abnormal_cell_death0.72036467
118MP0002088_abnormal_embryonic_growth/wei0.70401946
119MP0010352_gastrointestinal_tract_polyps0.70361779
120MP0002080_prenatal_lethality0.69462691
121MP0003890_abnormal_embryonic-extraembry0.68243265
122MP0004084_abnormal_cardiac_muscle0.68186644
123MP0005266_abnormal_metabolism0.66946621
124MP0004197_abnormal_fetal_growth/weight/0.66082765
125MP0003283_abnormal_digestive_organ0.64346974
126MP0003718_maternal_effect0.62117936
127MP0000358_abnormal_cell_content/0.60725572
128MP0002086_abnormal_extraembryonic_tissu0.59573511
129MP0000432_abnormal_head_morphology0.58795962
130MP0003861_abnormal_nervous_system0.57625186
131MP0000427_abnormal_hair_cycle0.52312426
132MP0001919_abnormal_reproductive_system0.49685424
133MP0002269_muscular_atrophy0.49630908
134MP0003787_abnormal_imprinting0.49372001
135MP0002928_abnormal_bile_duct0.46607747
136MP0001765_abnormal_ion_homeostasis0.44695041
137MP0002019_abnormal_tumor_incidence0.44226154
138MP0003941_abnormal_skin_development0.44105041
139MP0003119_abnormal_digestive_system0.43437782
140MP0005391_vision/eye_phenotype0.43357171
141MP0004036_abnormal_muscle_relaxation0.43284914
142MP0009697_abnormal_copulation0.42077365
143MP0003937_abnormal_limbs/digits/tail_de0.41134960
144MP0006036_abnormal_mitochondrial_physio0.40704020
145MP0003121_genomic_imprinting0.39590623
146MP0002092_abnormal_eye_morphology0.39116082
147MP0003705_abnormal_hypodermis_morpholog0.38698556
148MP0006072_abnormal_retinal_apoptosis0.38596925
149MP0005253_abnormal_eye_physiology0.37449400
150MP0003936_abnormal_reproductive_system0.37401090
151MP0001545_abnormal_hematopoietic_system0.35799916
152MP0005397_hematopoietic_system_phenotyp0.35799916
153MP0002102_abnormal_ear_morphology0.35473880
154MP0002132_abnormal_respiratory_system0.35122099
155MP0009703_decreased_birth_body0.32821135
156MP0008995_early_reproductive_senescence0.32454968
157MP0003115_abnormal_respiratory_system0.32246212
158MP0002152_abnormal_brain_morphology0.31020311
159MP0005076_abnormal_cell_differentiation0.30926195
160MP0002697_abnormal_eye_size0.30758569
161MP0001849_ear_inflammation0.29596943
162MP0001915_intracranial_hemorrhage0.29353426
163MP0008872_abnormal_physiological_respon0.26343255
164MP0002796_impaired_skin_barrier0.25498100
165MP0004134_abnormal_chest_morphology0.25294759
166MP0004808_abnormal_hematopoietic_stem0.23958131
167MP0005377_hearing/vestibular/ear_phenot0.23685987
168MP0003878_abnormal_ear_physiology0.23685987
169MP0002116_abnormal_craniofacial_bone0.22767752
170MP0002114_abnormal_axial_skeleton0.21669969

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.77502950
2Abnormal ciliary motility (HP:0012262)8.72821949
3Rhinitis (HP:0012384)8.08164756
4Abnormal respiratory motile cilium morphology (HP:0005938)7.93972626
5Abnormal respiratory epithelium morphology (HP:0012253)7.93972626
6Chronic bronchitis (HP:0004469)6.91106557
7Nasal polyposis (HP:0100582)5.79713824
8Infertility (HP:0000789)4.76188658
9Abnormality of the nasal mucosa (HP:0000433)4.74616368
10Bronchiectasis (HP:0002110)4.61780854
11Bronchitis (HP:0012387)4.33441831
12Nephronophthisis (HP:0000090)4.09216678
13Recurrent sinusitis (HP:0011108)3.49778488
14Tongue fasciculations (HP:0001308)3.40743008
15Male infertility (HP:0003251)3.24962030
16Molar tooth sign on MRI (HP:0002419)3.18108606
17Abnormality of midbrain morphology (HP:0002418)3.18108606
18Abnormal spermatogenesis (HP:0008669)3.17848153
19Medial flaring of the eyebrow (HP:0010747)3.13495107
20Muscle fibrillation (HP:0010546)3.07291980
21Abnormality of the renal medulla (HP:0100957)3.02908343
22Recurrent otitis media (HP:0000403)3.00391542
23Type II lissencephaly (HP:0007260)2.96111880
24Congenital stationary night blindness (HP:0007642)2.94924417
25Pancreatic fibrosis (HP:0100732)2.77640545
26Abolished electroretinogram (ERG) (HP:0000550)2.75611935
27Supernumerary spleens (HP:0009799)2.75434019
28Abnormality of the lower motor neuron (HP:0002366)2.63356745
29Recurrent bronchitis (HP:0002837)2.61665347
30Sclerocornea (HP:0000647)2.61261203
31Tubular atrophy (HP:0000092)2.59944564
32Median cleft lip (HP:0000161)2.57091426
33Retinal dysplasia (HP:0007973)2.50386688
34Attenuation of retinal blood vessels (HP:0007843)2.43707686
35Facial cleft (HP:0002006)2.42724601
36Azoospermia (HP:0000027)2.41620120
37Pendular nystagmus (HP:0012043)2.41335911
38Microglossia (HP:0000171)2.41238827
39Abnormality of macular pigmentation (HP:0008002)2.38819294
40Hyperventilation (HP:0002883)2.37067966
41Tubulointerstitial nephritis (HP:0001970)2.35064710
42Congenital hepatic fibrosis (HP:0002612)2.32032153
43Anencephaly (HP:0002323)2.30300903
44Postaxial foot polydactyly (HP:0001830)2.28864211
45Constricted visual fields (HP:0001133)2.23729392
46Chorioretinal atrophy (HP:0000533)2.22455257
47Impulsivity (HP:0100710)2.20896719
48Decreased central vision (HP:0007663)2.20138857
49Abnormal rod and cone electroretinograms (HP:0008323)2.18041182
50Male pseudohermaphroditism (HP:0000037)2.17962327
51Furrowed tongue (HP:0000221)2.16703074
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16363272
53Congenital primary aphakia (HP:0007707)2.16260714
54Gait imbalance (HP:0002141)2.14095360
55Tubulointerstitial abnormality (HP:0001969)2.13291325
56Broad-based gait (HP:0002136)2.12545678
57Short ribs (HP:0000773)2.11820443
58Fibular hypoplasia (HP:0003038)2.11685952
59Gaze-evoked nystagmus (HP:0000640)2.09548620
60Chronic sinusitis (HP:0011109)2.09434924
61Aplasia/Hypoplasia of the tongue (HP:0010295)2.06912967
62Selective tooth agenesis (HP:0001592)2.06561661
63Lissencephaly (HP:0001339)2.06162473
64Aplasia/Hypoplasia of the spleen (HP:0010451)2.02942033
65Mitochondrial inheritance (HP:0001427)2.02772180
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8975461
67Absent/shortened dynein arms (HP:0200106)10.4122807
68Dynein arm defect of respiratory motile cilia (HP:0012255)10.4122807
69Aplasia/Hypoplasia of the tibia (HP:0005772)1.98249578
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97717334
71Abnormality of alanine metabolism (HP:0010916)1.97717334
72Hyperalaninemia (HP:0003348)1.97717334
73Asplenia (HP:0001746)1.97493055
74Large for gestational age (HP:0001520)1.96323870
75Increased CSF lactate (HP:0002490)1.95759856
76Progressive cerebellar ataxia (HP:0002073)1.95553449
77Genetic anticipation (HP:0003743)1.94438870
78Amyotrophic lateral sclerosis (HP:0007354)1.93565136
79Congenital, generalized hypertrichosis (HP:0004540)1.93002704
80Absent frontal sinuses (HP:0002688)1.87815758
81Abdominal situs inversus (HP:0003363)1.87545140
82Abnormality of abdominal situs (HP:0011620)1.87545140
83Cerebellar dysplasia (HP:0007033)1.87413144
84Bony spicule pigmentary retinopathy (HP:0007737)1.85731993
85Postaxial hand polydactyly (HP:0001162)1.85056201
86Nephrogenic diabetes insipidus (HP:0009806)1.84908810
87Retinitis pigmentosa (HP:0000510)1.84654575
88Acute necrotizing encephalopathy (HP:0006965)1.84355773
89Renal cortical cysts (HP:0000803)1.83102583
90Tubulointerstitial fibrosis (HP:0005576)1.82715527
91Polyuria (HP:0000103)1.82512457
92Abnormal number of erythroid precursors (HP:0012131)1.82375398
93Optic nerve hypoplasia (HP:0000609)1.82345818
94True hermaphroditism (HP:0010459)1.82267441
95Inability to walk (HP:0002540)1.79331722
96Increased hepatocellular lipid droplets (HP:0006565)1.79298337
97Degeneration of anterior horn cells (HP:0002398)1.78984304
98Abnormality of the anterior horn cell (HP:0006802)1.78984304
99Oculomotor apraxia (HP:0000657)1.78831790
100Cystic liver disease (HP:0006706)1.78178839
101Optic disc pallor (HP:0000543)1.78106804
102Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.77642236
1033-Methylglutaconic aciduria (HP:0003535)1.77569798
104Increased corneal curvature (HP:0100692)1.76508835
105Keratoconus (HP:0000563)1.76508835
106Abnormality of ocular smooth pursuit (HP:0000617)1.75102224
107Occipital encephalocele (HP:0002085)1.75075461
108Short tibia (HP:0005736)1.74864364
109Acute encephalopathy (HP:0006846)1.74810713
110Thyroid-stimulating hormone excess (HP:0002925)1.74807824
111Progressive inability to walk (HP:0002505)1.74169635
112Abnormality of the pons (HP:0007361)1.73658841
113Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73409398
114Nephroblastoma (Wilms tumor) (HP:0002667)1.73186434
115Hemiparesis (HP:0001269)1.73007270
116Genital tract atresia (HP:0001827)1.72908577
117Abnormality of saccadic eye movements (HP:0000570)1.71545142
118Pancreatic cysts (HP:0001737)1.71512229
11911 pairs of ribs (HP:0000878)1.71491967
120Toxemia of pregnancy (HP:0100603)1.71269413
121Hepatocellular necrosis (HP:0001404)1.69554423
122Hepatic necrosis (HP:0002605)1.69048103
123Methylmalonic acidemia (HP:0002912)1.68602911
124Lipid accumulation in hepatocytes (HP:0006561)1.68002561
125Brushfield spots (HP:0001088)1.66832431
126Poor coordination (HP:0002370)1.66757529
127Stage 5 chronic kidney disease (HP:0003774)1.66578947
128Focal motor seizures (HP:0011153)1.64341494
129Abnormality of lateral ventricle (HP:0030047)1.62802096
130Renal dysplasia (HP:0000110)1.62032785
131Polydipsia (HP:0001959)1.60016730
132Abnormal drinking behavior (HP:0030082)1.60016730
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59704362
134Embryonal renal neoplasm (HP:0011794)1.59625746
135Gonadotropin excess (HP:0000837)1.58936340
136Abnormal biliary tract physiology (HP:0012439)1.57473171
137Bile duct proliferation (HP:0001408)1.57473171
138Impaired smooth pursuit (HP:0007772)1.55687752
139Sloping forehead (HP:0000340)1.54690012
140Chronic hepatic failure (HP:0100626)1.53900546
141Abnormality of the renal cortex (HP:0011035)1.52581923
142Vaginal atresia (HP:0000148)1.51216078
143Breast carcinoma (HP:0003002)1.49123432
144Abnormality of dentin (HP:0010299)1.49088947
145Preaxial hand polydactyly (HP:0001177)1.46063356
146Missing ribs (HP:0000921)1.45398377
147Upper motor neuron abnormality (HP:0002127)1.42851468
148Abnormality of permanent molar morphology (HP:0011071)1.41742569
149Abnormality of the dental root (HP:0006486)1.41742569
150Taurodontia (HP:0000679)1.41742569
151Aplasia/Hypoplasia of the fibula (HP:0006492)1.39281465
152J-shaped sella turcica (HP:0002680)1.37507824
153Limb ataxia (HP:0002070)1.37459038
154Spontaneous abortion (HP:0005268)1.35962314
155Abnormality of molar (HP:0011077)1.34850095
156Abnormality of molar morphology (HP:0011070)1.34850095
157Heterotopia (HP:0002282)1.30984193
158Abnormality of renal excretion (HP:0011036)1.28629092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.01899887
2PDK48.01899887
3PDK25.40644303
4FRK4.14836820
5WEE13.40279260
6TESK13.14988228
7ZAK3.05316218
8PNCK2.95186539
9ADRBK22.70092097
10TAF12.37542007
11PTK2B2.31292273
12MAP4K22.27843724
13BMPR1B2.27775830
14GRK12.27264411
15INSRR2.22550560
16PRKD32.13019439
17NEK22.08895285
18TTK2.08085187
19CDC72.07922400
20STK391.98444304
21WNK41.95793853
22ICK1.82397097
23TLK11.82239595
24MAPK131.74743853
25BRSK21.70149061
26PINK11.67143807
27NUAK11.59696095
28TAOK31.57026770
29OXSR11.56902545
30STK38L1.55987132
31TEC1.55516564
32BCKDK1.51551803
33CDK121.47673720
34MKNK21.46641355
35NTRK21.44600480
36CHEK21.39459976
37CASK1.38513125
38NTRK31.34643638
39CDK191.29148847
40STK381.28794095
41TXK1.27926287
42BUB11.26007428
43PASK1.24357320
44MKNK11.23382324
45PLK11.21468938
46PHKG21.16908463
47PHKG11.16908463
48NEK11.16666048
49PLK41.14817739
50ATR1.13951195
51MARK11.13223987
52ITK1.07949039
53ACVR1B1.06614799
54DYRK31.03394622
55KIT1.02704299
56ADRBK11.02376472
57TGFBR10.99194694
58CHEK10.98042435
59TESK20.97601902
60EIF2AK10.97394768
61PRKCE0.91647135
62AKT30.90527403
63EPHA40.88161592
64LMTK20.88116571
65TYRO30.87634778
66PIK3CA0.87323409
67CAMKK20.83622027
68PAK30.82792772
69STK30.82603453
70CCNB10.81246546
71TRIM280.80555091
72CDK30.79342978
73NME10.77762815
74TIE10.77535041
75ATM0.75974129
76PRKCQ0.75868689
77PDK10.75510566
78FGFR20.75348010
79AURKA0.70803404
80PKN10.70354180
81BRSK10.70281305
82PLK20.69780198
83VRK20.69271235
84ERBB30.68827929
85STK100.68646069
86MST40.67348798
87CAMKK10.66279235
88ERBB20.65333744
89RPS6KA50.64943472
90BCR0.64360682
91EPHA20.63409696
92MAP2K70.62278777
93WNK10.60953032
94TNIK0.59481714
95PLK30.58725707
96CSNK1G20.56718651
97CDK70.56680700
98SRPK10.55844734
99CAMK2A0.51843104
100BRAF0.51585680
101MAPKAPK50.51066706
102CSNK1G10.50691465
103MAPK150.50498575
104TSSK60.50337137
105CSNK1G30.48354147
106RPS6KA40.47800925
107PRKACA0.47769961
108NEK60.47759941
109CSNK2A20.47504779
110CDK20.45802530
111DAPK20.45706227
112CDK40.45529042
113AURKB0.45348516
114PAK10.45238882
115MAP3K40.44762008
116IKBKB0.43409933
117PRKG10.42515421
118FLT30.42097315
119RPS6KB20.41458867
120IGF1R0.40766825
121STK110.38873900
122MINK10.38451890
123CDK10.38444084
124CSNK1A10.37859017
125MUSK0.37117702
126CSNK2A10.36931288
127FES0.35432458
128SIK20.34666803
129MAPKAPK30.34359671
130MAP3K20.33704305
131BTK0.32372148
132STK160.32262239
133OBSCN0.32223424
134DYRK1B0.31705321
135PRKDC0.30280606
136EEF2K0.30144209
137CSNK1D0.29246888
138EIF2AK30.27110076
139CSNK1E0.25785773
140MAP2K60.25413021
141MTOR0.25110756
142PAK40.23324332
143PDPK10.22336724
144PRKCG0.21291811
145VRK10.21177536
146MET0.21036427
147RPS6KB10.20657501
148PRKCI0.20191241
149CDK60.19922503
150MARK30.19660380
151MAP3K80.19103552
152ZAP700.19084685
153PBK0.19071263
154GSK3B0.17735268
155MAPK100.17274315
156WNK30.14951607
157SCYL20.14833427
158YES10.14775959
159IRAK10.11149675
160MAPK140.11042221
161BRD40.11013199
162CDK150.09963175
163STK40.09184293
164PAK20.08179902
165CDK11A0.07963287
166MAPK10.07290736
167MELK0.07157557
168DYRK20.07078138
169CDK140.06842266
170MAPK80.06762557
171CDK180.06724981
172PIM10.06581295

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.72935993
2Pentose phosphate pathway_Homo sapiens_hsa000303.42752319
3Fanconi anemia pathway_Homo sapiens_hsa034603.41716778
4Vitamin B6 metabolism_Homo sapiens_hsa007503.38078941
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.19085339
6Pyruvate metabolism_Homo sapiens_hsa006203.16765772
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.15036330
8RNA transport_Homo sapiens_hsa030132.81924019
9Mismatch repair_Homo sapiens_hsa034302.80822816
10DNA replication_Homo sapiens_hsa030302.80380505
11Homologous recombination_Homo sapiens_hsa034402.70674070
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63094545
13Oxidative phosphorylation_Homo sapiens_hsa001902.62414688
14Phototransduction_Homo sapiens_hsa047442.53264534
15Propanoate metabolism_Homo sapiens_hsa006402.41341856
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28562995
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.23853303
18Parkinsons disease_Homo sapiens_hsa050122.17720205
19Oocyte meiosis_Homo sapiens_hsa041142.12205788
20Butanoate metabolism_Homo sapiens_hsa006502.10597932
21Cell cycle_Homo sapiens_hsa041102.06480235
22Biosynthesis of amino acids_Homo sapiens_hsa012302.05242525
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.04793602
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97783310
25Nicotine addiction_Homo sapiens_hsa050331.97492369
26Huntingtons disease_Homo sapiens_hsa050161.91577275
27Renin-angiotensin system_Homo sapiens_hsa046141.89096461
28Spliceosome_Homo sapiens_hsa030401.88709651
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87691114
30Protein export_Homo sapiens_hsa030601.86334213
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84922433
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82173230
33mRNA surveillance pathway_Homo sapiens_hsa030151.81212189
34Carbon metabolism_Homo sapiens_hsa012001.80909437
35Selenocompound metabolism_Homo sapiens_hsa004501.79462504
36Nitrogen metabolism_Homo sapiens_hsa009101.79454565
37Glucagon signaling pathway_Homo sapiens_hsa049221.75099721
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.73558248
39Nucleotide excision repair_Homo sapiens_hsa034201.70162881
40Caffeine metabolism_Homo sapiens_hsa002321.67002619
41Fatty acid biosynthesis_Homo sapiens_hsa000611.61776857
42Base excision repair_Homo sapiens_hsa034101.57125128
43Linoleic acid metabolism_Homo sapiens_hsa005911.53812536
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.53641278
45Olfactory transduction_Homo sapiens_hsa047401.51154220
46RNA degradation_Homo sapiens_hsa030181.50492094
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.47422207
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.45494063
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45306659
50Tryptophan metabolism_Homo sapiens_hsa003801.44259623
51Non-homologous end-joining_Homo sapiens_hsa034501.44110878
52Purine metabolism_Homo sapiens_hsa002301.42477841
53Alzheimers disease_Homo sapiens_hsa050101.41820268
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39791394
55Peroxisome_Homo sapiens_hsa041461.37012010
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35331375
57Proteasome_Homo sapiens_hsa030501.32205437
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.29721863
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24287975
60Pyrimidine metabolism_Homo sapiens_hsa002401.23272281
61beta-Alanine metabolism_Homo sapiens_hsa004101.19044886
62Lysine degradation_Homo sapiens_hsa003101.18904487
63Histidine metabolism_Homo sapiens_hsa003401.15479598
64Glutathione metabolism_Homo sapiens_hsa004801.12590353
65Retinol metabolism_Homo sapiens_hsa008301.11773876
66Glycerolipid metabolism_Homo sapiens_hsa005611.11136578
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08655719
68Morphine addiction_Homo sapiens_hsa050321.07634593
69Steroid hormone biosynthesis_Homo sapiens_hsa001401.07217014
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05091942
71Systemic lupus erythematosus_Homo sapiens_hsa053221.05058287
72ABC transporters_Homo sapiens_hsa020101.04924793
73Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01196073
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98627998
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93537996
76Fructose and mannose metabolism_Homo sapiens_hsa000510.91946105
77Antigen processing and presentation_Homo sapiens_hsa046120.87378235
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84309627
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83091801
80p53 signaling pathway_Homo sapiens_hsa041150.81322075
81Primary immunodeficiency_Homo sapiens_hsa053400.81240623
82GABAergic synapse_Homo sapiens_hsa047270.80725208
83One carbon pool by folate_Homo sapiens_hsa006700.80645524
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.80026186
85Serotonergic synapse_Homo sapiens_hsa047260.77823864
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.77204953
87Circadian entrainment_Homo sapiens_hsa047130.77151073
88Insulin secretion_Homo sapiens_hsa049110.76501614
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76480945
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75520655
91Salivary secretion_Homo sapiens_hsa049700.74032711
92Viral carcinogenesis_Homo sapiens_hsa052030.73750583
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73222629
94Glutamatergic synapse_Homo sapiens_hsa047240.72216113
95Dorso-ventral axis formation_Homo sapiens_hsa043200.69423522
96Sulfur metabolism_Homo sapiens_hsa009200.66849741
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66831029
98PPAR signaling pathway_Homo sapiens_hsa033200.66815012
99Cardiac muscle contraction_Homo sapiens_hsa042600.64606687
100Regulation of autophagy_Homo sapiens_hsa041400.61244329
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60602098
102Ribosome_Homo sapiens_hsa030100.60117154
103Cocaine addiction_Homo sapiens_hsa050300.59540524
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59415371
105Steroid biosynthesis_Homo sapiens_hsa001000.59413760
106Asthma_Homo sapiens_hsa053100.58661868
107Epstein-Barr virus infection_Homo sapiens_hsa051690.58038455
108Fat digestion and absorption_Homo sapiens_hsa049750.57594322
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56165750
110Amphetamine addiction_Homo sapiens_hsa050310.55832360
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55408061
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54821202
113Type I diabetes mellitus_Homo sapiens_hsa049400.50825228
114Sulfur relay system_Homo sapiens_hsa041220.50443947
115Ether lipid metabolism_Homo sapiens_hsa005650.50358007
116Mineral absorption_Homo sapiens_hsa049780.49710868
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49150586
118Tyrosine metabolism_Homo sapiens_hsa003500.48238737
119RNA polymerase_Homo sapiens_hsa030200.47956379
120Metabolic pathways_Homo sapiens_hsa011000.45173462
121Arachidonic acid metabolism_Homo sapiens_hsa005900.44220976
122Ovarian steroidogenesis_Homo sapiens_hsa049130.43220743
123Chemical carcinogenesis_Homo sapiens_hsa052040.41554165
124Vitamin digestion and absorption_Homo sapiens_hsa049770.41220031
125Long-term depression_Homo sapiens_hsa047300.41173740
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33309615
127Collecting duct acid secretion_Homo sapiens_hsa049660.31975078
128Graft-versus-host disease_Homo sapiens_hsa053320.31390535
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.31375137
130Tight junction_Homo sapiens_hsa045300.30905935
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30377233
132HTLV-I infection_Homo sapiens_hsa051660.29613877
133Renin secretion_Homo sapiens_hsa049240.27545373
134Fatty acid degradation_Homo sapiens_hsa000710.24995626
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23964165
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23590311
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21699793
138Thyroid hormone synthesis_Homo sapiens_hsa049180.21635784
139N-Glycan biosynthesis_Homo sapiens_hsa005100.21330942
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.21299729
141Alcoholism_Homo sapiens_hsa050340.21073641
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21066135
143Estrogen signaling pathway_Homo sapiens_hsa049150.19962795
144AMPK signaling pathway_Homo sapiens_hsa041520.16878934
145Inositol phosphate metabolism_Homo sapiens_hsa005620.16159155
146Herpes simplex infection_Homo sapiens_hsa051680.16080553
147Legionellosis_Homo sapiens_hsa051340.12357720
148Hippo signaling pathway_Homo sapiens_hsa043900.12355527
149Hedgehog signaling pathway_Homo sapiens_hsa043400.11586261
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.10624653
151TGF-beta signaling pathway_Homo sapiens_hsa043500.09867322
152Phosphatidylinositol signaling system_Homo sapiens_hsa040700.09275817
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07600445
154Wnt signaling pathway_Homo sapiens_hsa043100.07482278
155Basal cell carcinoma_Homo sapiens_hsa052170.07261139
156Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.07095265
157Taste transduction_Homo sapiens_hsa047420.06696699
158Calcium signaling pathway_Homo sapiens_hsa040200.06554268

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