ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	9.96944249
2	acrosome reaction (GO:0007340)	9.37778091
3	plasma membrane fusion (GO:0045026)	7.58997584
4	spermatid development (GO:0007286)	7.05322846
5	centriole replication (GO:0007099)	7.03848332
6	protein polyglutamylation (GO:0018095)	6.96616469
7	protein targeting to Golgi (GO:0000042)	6.76071220
8	multicellular organism reproduction (GO:0032504)	6.73404706
9	establishment of protein localization to Golgi (GO:0072600)	6.56709172
10	response to pheromone (GO:0019236)	6.50392511
11	sperm-egg recognition (GO:0035036)	6.30940585
12	axonemal dynein complex assembly (GO:0070286)	6.24564331
13	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.11376828
14	microtubule depolymerization (GO:0007019)	5.94010392
15	single strand break repair (GO:0000012)	5.90908521
16	chromosome condensation (GO:0030261)	5.88529362
17	rRNA methylation (GO:0031167)	5.83271416
18	DNA packaging (GO:0006323)	5.81345972
19	sperm capacitation (GO:0048240)	5.73039696
20	cilium or flagellum-dependent cell motility (GO:0001539)	5.71656885
21	centriole assembly (GO:0098534)	5.71482287
22	reproduction (GO:0000003)	5.69108034
23	cell wall macromolecule metabolic process (GO:0044036)	5.63862437
24	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.50100652
25	seminiferous tubule development (GO:0072520)	5.46285831
26	calcium ion-dependent exocytosis (GO:0017156)	5.43132209
27	phosphatidylethanolamine metabolic process (GO:0046337)	5.37010727
28	rRNA modification (GO:0000154)	5.36197918
29	regulation of cilium movement (GO:0003352)	5.33088682
30	microtubule polymerization or depolymerization (GO:0031109)	5.29851529
31	cell wall macromolecule catabolic process (GO:0016998)	5.27186962
32	binding of sperm to zona pellucida (GO:0007339)	5.24935770
33	spermatogenesis (GO:0007283)	5.24615195
34	male gamete generation (GO:0048232)	5.22977646
35	cell-cell recognition (GO:0009988)	5.14405909
36	spermatid nucleus differentiation (GO:0007289)	5.14016620
37	protein localization to Golgi apparatus (GO:0034067)	5.10780853
38	cellular ketone body metabolic process (GO:0046950)	4.98416152
39	epithelial cilium movement (GO:0003351)	4.94249841
40	gamete generation (GO:0007276)	4.82197149
41	single fertilization (GO:0007338)	4.82041158
42	regulation of centriole replication (GO:0046599)	4.74437236
43	microtubule severing (GO:0051013)	4.67920576
44	ketone body metabolic process (GO:1902224)	4.41157683
45	cilium movement (GO:0003341)	4.39785280
46	piRNA metabolic process (GO:0034587)	4.32652908
47	fertilization (GO:0009566)	4.12672174
48	coenzyme catabolic process (GO:0009109)	4.07781593
49	motile cilium assembly (GO:0044458)	4.06944924
50	male meiosis (GO:0007140)	4.03747120
51	germ cell development (GO:0007281)	3.98984754
52	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.82867121
53	organic cation transport (GO:0015695)	3.78333078
54	multicellular organismal reproductive process (GO:0048609)	3.77267775
55	male meiosis I (GO:0007141)	3.71947182
56	negative regulation of inclusion body assembly (GO:0090084)	3.70665208
57	sexual reproduction (GO:0019953)	3.65264259
58	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.64504293
59	regulation of microtubule-based movement (GO:0060632)	3.46901425
60	RNA destabilization (GO:0050779)	3.42337903
61	axoneme assembly (GO:0035082)	3.37665637
62	positive regulation of Rab GTPase activity (GO:0032851)	3.37315348
63	regulation of Rab GTPase activity (GO:0032313)	3.37315348
64	regulation of meiosis I (GO:0060631)	3.35641066
65	DNA methylation involved in gamete generation (GO:0043046)	3.33021134
66	polyamine biosynthetic process (GO:0006596)	3.32124948
67	musculoskeletal movement (GO:0050881)	3.18039064
68	multicellular organismal movement (GO:0050879)	3.18039064
69	glomerular visceral epithelial cell development (GO:0072015)	3.15559233
70	microtubule nucleation (GO:0007020)	3.14922673
71	intra-Golgi vesicle-mediated transport (GO:0006891)	3.09240842
72	regulation of transcription involved in cell fate commitment (GO:0060850)	3.05552235
73	regulation of inclusion body assembly (GO:0090083)	3.04624083
74	regulation of somitogenesis (GO:0014807)	3.00164376
75	glomerular epithelial cell development (GO:0072310)	2.97245358
76	positive regulation of guanylate cyclase activity (GO:0031284)	2.96967209
77	histone exchange (GO:0043486)	2.96368607
78	ventricular system development (GO:0021591)	2.92870935
79	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.90402545
80	cofactor catabolic process (GO:0051187)	2.83700881
81	glycerol ether metabolic process (GO:0006662)	2.83013241
82	meiosis I (GO:0007127)	2.81161095
83	cellular biogenic amine biosynthetic process (GO:0042401)	2.81115656
84	nucleus organization (GO:0006997)	2.80146799
85	cellular biogenic amine catabolic process (GO:0042402)	2.74463660
86	amine catabolic process (GO:0009310)	2.74463660
87	chromatin silencing (GO:0006342)	2.74042524
88	cilium organization (GO:0044782)	2.72106218
89	spinal cord motor neuron differentiation (GO:0021522)	2.71207969
90	acrosome assembly (GO:0001675)	2.70516497
91	cilium assembly (GO:0042384)	2.70058639
92	regulation of guanylate cyclase activity (GO:0031282)	2.66784318
93	ether metabolic process (GO:0018904)	2.64639393
94	amine biosynthetic process (GO:0009309)	2.64571934
95	cell recognition (GO:0008037)	2.61604204
96	nephron epithelium morphogenesis (GO:0072088)	2.60062043
97	nephron tubule morphogenesis (GO:0072078)	2.60062043
98	chemosensory behavior (GO:0007635)	2.58440719
99	detection of light stimulus involved in sensory perception (GO:0050962)	2.57702917
100	sperm motility (GO:0030317)	10.1065823

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.56011901
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.25454123
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.10877168
4	FUS_26573619_Chip-Seq_HEK293_Human	2.93278537
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.71604551
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.58856011
7	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.57625645
8	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.49514871
9	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.49514871
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.43612099
11	VDR_22108803_ChIP-Seq_LS180_Human	2.39275159
12	CBP_20019798_ChIP-Seq_JUKART_Human	2.18979675
13	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.18979675
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.06665787
15	P300_19829295_ChIP-Seq_ESCs_Human	2.04026992
16	GBX2_23144817_ChIP-Seq_PC3_Human	1.99608335
17	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.98614897
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.96808935
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.94547988
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.79161288
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.71463531
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.67434685
23	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.64808398
24	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.62855419
25	NANOG_20526341_ChIP-Seq_ESCs_Human	1.62511564
26	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.57719449
27	IGF1R_20145208_ChIP-Seq_DFB_Human	1.56941530
28	AR_25329375_ChIP-Seq_VCAP_Human	1.54109222
29	MYC_19829295_ChIP-Seq_ESCs_Human	1.52519279
30	RAC3_21632823_ChIP-Seq_H3396_Human	1.52101104
31	ERA_21632823_ChIP-Seq_H3396_Human	1.51591632
32	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.50964735
33	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.50121660
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49577777
35	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.48910987
36	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.48446834
37	NANOG_19829295_ChIP-Seq_ESCs_Human	1.46952235
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.46952235
39	RBPJ_21746931_ChIP-Seq_IB4_Human	1.46343362
40	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.46004364
41	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.43308209
42	ETV1_20927104_ChIP-Seq_GIST48_Human	1.42466008
43	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.42044039
44	STAT3_23295773_ChIP-Seq_U87_Human	1.41454204
45	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.40218105
46	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.39353170
47	PHF8_20622853_ChIP-Seq_HELA_Human	1.39270614
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.38204192
49	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.37663388
50	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.37137895
51	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.36769284
52	NFYB_21822215_ChIP-Seq_K562_Human	1.35779333
53	RUNX2_22187159_ChIP-Seq_PCA_Human	1.34491376
54	TBL1_22424771_ChIP-Seq_293T_Human	1.34256613
55	TAF15_26573619_Chip-Seq_HEK293_Human	1.32085358
56	ERG_20517297_ChIP-Seq_VCAP_Human	1.30758190
57	OCT4_20526341_ChIP-Seq_ESCs_Human	1.29620377
58	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.28617243
59	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.28447197
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.28133424
61	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.27977296
62	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27499176
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27499176
64	TAF2_19829295_ChIP-Seq_ESCs_Human	1.27012683
65	HOXB7_26014856_ChIP-Seq_BT474_Human	1.26888573
66	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25396144
67	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.24377397
68	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.23577587
69	IRF1_19129219_ChIP-ChIP_H3396_Human	1.23051911
70	NCOR_22424771_ChIP-Seq_293T_Human	1.22283079
71	TP53_18474530_ChIP-ChIP_U2OS_Human	1.21618155
72	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.20934181
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20709768
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.20326873
75	TCF4_23295773_ChIP-Seq_U87_Human	1.20024504
76	NFYA_21822215_ChIP-Seq_K562_Human	1.19717559
77	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19611129
78	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.19487949
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18708121
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.18605614
81	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.17541322
82	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.16808748
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.15524481
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15013835
85	DROSHA_22980978_ChIP-Seq_HELA_Human	1.13473909
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11997035
87	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.11980532
88	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.11287490
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.11194466
90	AR_21572438_ChIP-Seq_LNCaP_Human	1.11028241
91	TP53_22573176_ChIP-Seq_HFKS_Human	1.07496280
92	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06707575
93	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.04839817
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.03511806
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02982593
96	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.02686982
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02459625
98	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01292816
99	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.01175726
100	CTCF_20526341_ChIP-Seq_ESCs_Human	1.00273295

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.65639134
2	MP0003878_abnormal_ear_physiology	4.92492785
3	MP0005377_hearing/vestibular/ear_phenot	4.92492785
4	MP0003011_delayed_dark_adaptation	3.51870443
5	MP0003698_abnormal_male_reproductive	3.38592380
6	MP0001929_abnormal_gametogenesis	2.95200363
7	MP0001968_abnormal_touch/_nociception	2.62886410
8	MP0005670_abnormal_white_adipose	2.44836985
9	MP0008877_abnormal_DNA_methylation	2.41040233
10	MP0003880_abnormal_central_pattern	2.34951791
11	MP0003646_muscle_fatigue	2.27848590
12	MP0001485_abnormal_pinna_reflex	2.15724398
13	MP0003718_maternal_effect	2.14990648
14	MP0001486_abnormal_startle_reflex	2.03375862
15	MP0005551_abnormal_eye_electrophysiolog	1.98064899
16	MP0005379_endocrine/exocrine_gland_phen	1.87706732
17	MP0002736_abnormal_nociception_after	1.83806962
18	MP0002161_abnormal_fertility/fecundity	1.82068375
19	MP0002653_abnormal_ependyma_morphology	1.79551981
20	MP0002210_abnormal_sex_determination	1.70364210
21	MP0003136_yellow_coat_color	1.67829306
22	MP0003195_calcinosis	1.66332828
23	MP0006276_abnormal_autonomic_nervous	1.60488452
24	MP0001986_abnormal_taste_sensitivity	1.55559211
25	MP0001145_abnormal_male_reproductive	1.48669441
26	MP0005253_abnormal_eye_physiology	1.44526859
27	MP0001984_abnormal_olfaction	1.43890972
28	MP0000653_abnormal_sex_gland	1.43059493
29	MP0005645_abnormal_hypothalamus_physiol	1.42713108
30	MP0005423_abnormal_somatic_nervous	1.38202872
31	MP0008995_early_reproductive_senescence	1.38177454
32	MP0006292_abnormal_olfactory_placode	1.37205699
33	MP0002735_abnormal_chemical_nociception	1.33326920
34	MP0002837_dystrophic_cardiac_calcinosis	1.25765126
35	MP0001963_abnormal_hearing_physiology	1.25002673
36	MP0002733_abnormal_thermal_nociception	1.24315445
37	MP0002102_abnormal_ear_morphology	1.20136393
38	MP0005395_other_phenotype	1.16390650
39	MP0002557_abnormal_social/conspecific_i	1.11959754
40	MP0000026_abnormal_inner_ear	1.10660350
41	MP0004742_abnormal_vestibular_system	1.10093786
42	MP0001348_abnormal_lacrimal_gland	1.08912007
43	MP0002638_abnormal_pupillary_reflex	1.05890780
44	MP0009745_abnormal_behavioral_response	1.04998935
45	MP0002272_abnormal_nervous_system	1.00234797
46	MP0002067_abnormal_sensory_capabilities	0.98953278
47	MP0002132_abnormal_respiratory_system	0.97703839
48	MP0003879_abnormal_hair_cell	0.97697642
49	MP0001905_abnormal_dopamine_level	0.97348208
50	MP0010329_abnormal_lipoprotein_level	0.94834704
51	MP0005084_abnormal_gallbladder_morpholo	0.94310563
52	MP0001970_abnormal_pain_threshold	0.92924473
53	MP0009697_abnormal_copulation	0.92402866
54	MP0002572_abnormal_emotion/affect_behav	0.92091788
55	MP0001501_abnormal_sleep_pattern	0.91811340
56	MP0008872_abnormal_physiological_respon	0.91782445
57	MP0005636_abnormal_mineral_homeostasis	0.90901348
58	MP0008789_abnormal_olfactory_epithelium	0.88111537
59	MP0002127_abnormal_cardiovascular_syste	0.87755776
60	MP0002138_abnormal_hepatobiliary_system	0.87402132
61	MP0003045_fibrosis	0.87350380
62	MP0005646_abnormal_pituitary_gland	0.86423506
63	MP0002229_neurodegeneration	0.86092302
64	MP0000631_abnormal_neuroendocrine_gland	0.83970367
65	MP0002234_abnormal_pharynx_morphology	0.81232723
66	MP0001765_abnormal_ion_homeostasis	0.80836585
67	MP0002928_abnormal_bile_duct	0.80556797
68	MP0000049_abnormal_middle_ear	0.80343432
69	MP0002876_abnormal_thyroid_physiology	0.80141020
70	MP0005360_urolithiasis	0.79717894
71	MP0000955_abnormal_spinal_cord	0.78852014
72	MP0002282_abnormal_trachea_morphology	0.78672214
73	MP0009046_muscle_twitch	0.76372013
74	MP0001919_abnormal_reproductive_system	0.74975751
75	MP0002734_abnormal_mechanical_nocicepti	0.74944477
76	MP0005389_reproductive_system_phenotype	0.73704960
77	MP0003137_abnormal_impulse_conducting	0.71440966
78	MP0000230_abnormal_systemic_arterial	0.71407254
79	MP0002160_abnormal_reproductive_system	0.71104201
80	MP0002938_white_spotting	0.71025603
81	MP0004085_abnormal_heartbeat	0.69492393
82	MP0003936_abnormal_reproductive_system	0.68141756
83	MP0003119_abnormal_digestive_system	0.67555828
84	MP0006072_abnormal_retinal_apoptosis	0.66090989
85	MP0000013_abnormal_adipose_tissue	0.66089551
86	MP0000678_abnormal_parathyroid_gland	0.65922479
87	MP0002249_abnormal_larynx_morphology	0.64592716
88	MP0004019_abnormal_vitamin_homeostasis	0.62507754
89	MP0004859_abnormal_synaptic_plasticity	0.62427043
90	MP0002163_abnormal_gland_morphology	0.62348728
91	MP0005310_abnormal_salivary_gland	0.62342167
92	MP0010368_abnormal_lymphatic_system	0.62188731
93	MP0000566_synostosis	0.61509017
94	MP0002168_other_aberrant_phenotype	0.61456707
95	MP0005394_taste/olfaction_phenotype	0.61450876
96	MP0005499_abnormal_olfactory_system	0.61450876
97	MP0002064_seizures	0.59807212
98	MP0005391_vision/eye_phenotype	0.59664002
99	MP0003635_abnormal_synaptic_transmissio	0.58512187
100	MP0002752_abnormal_somatic_nervous	0.58413569

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	5.53901831
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.53901831
3	Chronic hepatic failure (HP:0100626)	5.31979408
4	Severe visual impairment (HP:0001141)	5.04163841
5	Tubulointerstitial nephritis (HP:0001970)	4.85593534
6	Abnormal ciliary motility (HP:0012262)	4.71831878
7	Abnormal respiratory motile cilium physiology (HP:0012261)	4.56429902
8	Abnormal respiratory epithelium morphology (HP:0012253)	4.55626069
9	Abnormal respiratory motile cilium morphology (HP:0005938)	4.55626069
10	Attenuation of retinal blood vessels (HP:0007843)	4.51275094
11	Abnormality of macular pigmentation (HP:0008002)	4.08377383
12	Bony spicule pigmentary retinopathy (HP:0007737)	4.04332969
13	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.96426753
14	Nephronophthisis (HP:0000090)	3.43937518
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.40318945
16	Infertility (HP:0000789)	3.28601875
17	Pancreatic fibrosis (HP:0100732)	3.16193733
18	Male infertility (HP:0003251)	3.16021594
19	True hermaphroditism (HP:0010459)	3.12477534
20	Asymmetric septal hypertrophy (HP:0001670)	3.11312426
21	Pancreatic cysts (HP:0001737)	3.02541875
22	Abnormality of the renal medulla (HP:0100957)	2.93246120
23	Optic nerve hypoplasia (HP:0000609)	2.91593989
24	Progressive cerebellar ataxia (HP:0002073)	2.85941564
25	Amelogenesis imperfecta (HP:0000705)	2.82918457
26	Abnormality of dental color (HP:0011073)	2.76161499
27	Abnormal drinking behavior (HP:0030082)	2.73587426
28	Polydipsia (HP:0001959)	2.73587426
29	Rhinitis (HP:0012384)	2.71973167
30	Pendular nystagmus (HP:0012043)	2.65765499
31	Impulsivity (HP:0100710)	2.59167078
32	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.55613489
33	Cone-rod dystrophy (HP:0000548)	2.53898367
34	Hypoalphalipoproteinemia (HP:0003233)	2.51399715
35	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.49529780
36	Hyperkalemia (HP:0002153)	2.43297879
37	Tubular atrophy (HP:0000092)	2.41389524
38	Potter facies (HP:0002009)	2.37149753
39	Facial shape deformation (HP:0011334)	2.37149753
40	Tubulointerstitial abnormality (HP:0001969)	2.36866207
41	Renal Fanconi syndrome (HP:0001994)	2.35369308
42	Abnormal spermatogenesis (HP:0008669)	2.35002517
43	Chronic bronchitis (HP:0004469)	2.32924027
44	Abnormal urine output (HP:0012590)	2.30593452
45	Decreased central vision (HP:0007663)	2.29541190
46	Nasal polyposis (HP:0100582)	2.27468826
47	Cerebellar dysplasia (HP:0007033)	2.27452020
48	Polyuria (HP:0000103)	2.26550579
49	Type II lissencephaly (HP:0007260)	2.22911558
50	Insulin-resistant diabetes mellitus (HP:0000831)	2.21621033
51	Congenital sensorineural hearing impairment (HP:0008527)	2.18506684
52	Bronchiectasis (HP:0002110)	2.14967874
53	Azoospermia (HP:0000027)	2.13485193
54	Molar tooth sign on MRI (HP:0002419)	2.12215849
55	Abnormality of midbrain morphology (HP:0002418)	2.12215849
56	Generalized aminoaciduria (HP:0002909)	2.11806267
57	Resting tremor (HP:0002322)	2.07776318
58	Stage 5 chronic kidney disease (HP:0003774)	2.06289046
59	Sclerocornea (HP:0000647)	2.06154816
60	Glycosuria (HP:0003076)	2.05390291
61	Abnormality of urine glucose concentration (HP:0011016)	2.05390291
62	Growth hormone deficiency (HP:0000824)	2.03765535
63	Postural instability (HP:0002172)	2.03685589
64	Male pseudohermaphroditism (HP:0000037)	2.02651368
65	Anencephaly (HP:0002323)	2.02640236
66	Abnormality of renal excretion (HP:0011036)	2.00940176
67	Tetany (HP:0001281)	1.96461334
68	Cystic liver disease (HP:0006706)	1.95397769
69	Hypoplasia of the thymus (HP:0000778)	1.95026706
70	Scotoma (HP:0000575)	1.86232183
71	Photophobia (HP:0000613)	1.84586420
72	Congenital stationary night blindness (HP:0007642)	1.83607852
73	Abnormality of the aortic arch (HP:0012303)	1.82625035
74	Progressive sensorineural hearing impairment (HP:0000408)	1.82523740
75	Abnormality of the renal cortex (HP:0011035)	1.81793683
76	Occipital encephalocele (HP:0002085)	1.81037955
77	Menstrual irregularities (HP:0000858)	1.79960984
78	Abnormal albumin level (HP:0012116)	1.78924239
79	Hypoalbuminemia (HP:0003073)	1.78924239
80	Renal dysplasia (HP:0000110)	1.78244677
81	Type 2 muscle fiber atrophy (HP:0003554)	1.77229973
82	Hypoplastic ischia (HP:0003175)	1.76728281
83	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.75509055
84	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.74896618
85	Portal hypertension (HP:0001409)	1.72916663
86	Abnormality of the ischium (HP:0003174)	1.72542245
87	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.71562072
88	Horizontal nystagmus (HP:0000666)	1.70369474
89	Renovascular hypertension (HP:0100817)	1.70214436
90	Abolished electroretinogram (ERG) (HP:0000550)	1.69305823
91	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.67731833
92	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.65149805
93	Myokymia (HP:0002411)	1.64993746
94	Pigmentary retinal degeneration (HP:0001146)	1.64922640
95	Keratoconus (HP:0000563)	1.64892091
96	Increased corneal curvature (HP:0100692)	1.64892091
97	Congenital hepatic fibrosis (HP:0002612)	1.64716011
98	Gastrointestinal atresia (HP:0002589)	1.64621822
99	Poor coordination (HP:0002370)	1.64197931
100	Type II diabetes mellitus (HP:0005978)	1.63886629

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.00006898
2	INSRR	4.63584076
3	STK38L	3.33087718
4	PLK2	3.09981668
5	KDR	3.00385470
6	PINK1	2.93076264
7	MAP4K2	2.89031247
8	PNCK	2.73485286
9	FRK	2.47827769
10	TESK1	2.41748559
11	BRD4	2.05832637
12	PIK3CG	1.97320727
13	STK38	1.92033821
14	PRKD3	1.76267036
15	ADRBK2	1.62956561
16	TNIK	1.60982674
17	ZAK	1.58327263
18	NUAK1	1.40968811
19	MAPK15	1.38358092
20	WNK3	1.35886689
21	NEK6	1.34540039
22	AKT3	1.34384221
23	CAMK1G	1.26397780
24	CASK	1.24645212
25	GRK1	1.22535064
26	TIE1	1.19515262
27	PTK2B	1.18596968
28	WNK4	1.18409383
29	STK39	1.18053666
30	DDR2	1.15964857
31	BMPR1B	1.15415579
32	DYRK2	1.09648404
33	TYRO3	1.03519106
34	OXSR1	1.03251296
35	CDK3	1.02766949
36	BLK	0.98798111
37	WNK1	0.98299270
38	MAP3K4	0.97822163
39	TLK1	0.96201635
40	MAP2K7	0.96106424
41	MUSK	0.92415586
42	LATS1	0.90345483
43	PRKCG	0.79872267
44	PDK1	0.77643404
45	PRKG1	0.76915484
46	NTRK3	0.75220853
47	EPHA4	0.69608588
48	MAPK13	0.67504889
49	MARK1	0.67354994
50	BCKDK	0.67251925
51	TESK2	0.65875879
52	PRKCE	0.65674280
53	TXK	0.63638701
54	PDPK1	0.63161077
55	TRIM28	0.62288257
56	NME1	0.59821852
57	VRK1	0.59145351
58	ACVR1B	0.57190389
59	BRSK2	0.56448161
60	VRK2	0.55520569
61	TAOK3	0.53261705
62	CDC7	0.52934876
63	PLK1	0.50046101
64	PRKAA2	0.48976956
65	PRKG2	0.46017899
66	CAMK1	0.45735414
67	PRKCQ	0.44999211
68	CDK7	0.43105734
69	BRAF	0.39379266
70	CAMK2A	0.38344371
71	MAP3K9	0.37343235
72	MARK3	0.36623732
73	PAK3	0.34405440
74	ADRBK1	0.33692007
75	PRKACA	0.33288292
76	BRSK1	0.32629153
77	CSNK1G2	0.31127913
78	PLK3	0.30960214
79	CDK2	0.29736732
80	TEC	0.29481766
81	OBSCN	0.28366035
82	CSNK1A1	0.28196011
83	CDK1	0.27840298
84	CSNK1E	0.27100615
85	ROCK1	0.26221304
86	CDK19	0.26090866
87	LATS2	0.25662936
88	MAPK1	0.25321111
89	GSK3B	0.25098265
90	PIK3CA	0.23378977
91	RPS6KA5	0.23125040
92	GRK7	0.22574286
93	PRKACB	0.22431390
94	STK4	0.21804219
95	PRKCZ	0.21486432
96	PDK2	0.21460713
97	PRKCA	0.20983818
98	PRKCB	0.20597831
99	DYRK1B	0.20162160
100	SGK223	0.19490597

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.85585589
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.40942024
3	Butanoate metabolism_Homo sapiens_hsa00650	3.05478956
4	Olfactory transduction_Homo sapiens_hsa04740	2.96317072
5	Phototransduction_Homo sapiens_hsa04744	2.61484991
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.00254596
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89679333
8	Oxidative phosphorylation_Homo sapiens_hsa00190	1.87553282
9	Nitrogen metabolism_Homo sapiens_hsa00910	1.86439783
10	Taste transduction_Homo sapiens_hsa04742	1.84943276
11	Selenocompound metabolism_Homo sapiens_hsa00450	1.82702393
12	Basal transcription factors_Homo sapiens_hsa03022	1.78629273
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76119611
14	RNA transport_Homo sapiens_hsa03013	1.67044722
15	Nicotine addiction_Homo sapiens_hsa05033	1.64927509
16	Huntingtons disease_Homo sapiens_hsa05016	1.58695654
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57188442
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.54037580
19	Parkinsons disease_Homo sapiens_hsa05012	1.53198763
20	Retinol metabolism_Homo sapiens_hsa00830	1.51337333
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51035226
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.50883282
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.48629465
24	RNA polymerase_Homo sapiens_hsa03020	1.47320897
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43358057
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34529937
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.29470398
28	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.29251150
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.27474314
30	Fat digestion and absorption_Homo sapiens_hsa04975	1.26805499
31	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.21965843
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.20790375
33	Fatty acid degradation_Homo sapiens_hsa00071	1.19707030
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.15651776
35	Morphine addiction_Homo sapiens_hsa05032	1.15575081
36	Glutamatergic synapse_Homo sapiens_hsa04724	1.13498522
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.12084497
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.05924450
39	Propanoate metabolism_Homo sapiens_hsa00640	1.05066825
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.04715236
41	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.03222739
42	Purine metabolism_Homo sapiens_hsa00230	0.99349027
43	ABC transporters_Homo sapiens_hsa02010	0.98030954
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96617763
45	GABAergic synapse_Homo sapiens_hsa04727	0.95869795
46	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.93637598
47	Alzheimers disease_Homo sapiens_hsa05010	0.92255150
48	Homologous recombination_Homo sapiens_hsa03440	0.92238625
49	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.91895362
50	Insulin secretion_Homo sapiens_hsa04911	0.88581582
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.86247414
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85835260
53	Circadian entrainment_Homo sapiens_hsa04713	0.85465429
54	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85231673
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82381939
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.80558878
57	Phenylalanine metabolism_Homo sapiens_hsa00360	0.78269373
58	Peroxisome_Homo sapiens_hsa04146	0.77050054
59	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.73047910
60	Caffeine metabolism_Homo sapiens_hsa00232	0.72378110
61	Metabolic pathways_Homo sapiens_hsa01100	0.72314375
62	Calcium signaling pathway_Homo sapiens_hsa04020	0.71089218
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.69206178
64	Sulfur relay system_Homo sapiens_hsa04122	0.68971250
65	PPAR signaling pathway_Homo sapiens_hsa03320	0.68459990
66	Serotonergic synapse_Homo sapiens_hsa04726	0.68083419
67	Salivary secretion_Homo sapiens_hsa04970	0.67556749
68	Regulation of autophagy_Homo sapiens_hsa04140	0.63215441
69	Oocyte meiosis_Homo sapiens_hsa04114	0.61304539
70	One carbon pool by folate_Homo sapiens_hsa00670	0.60988230
71	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59122297
72	Antigen processing and presentation_Homo sapiens_hsa04612	0.57170321
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.56681025
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56675048
75	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.56124061
76	Protein export_Homo sapiens_hsa03060	0.55954558
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54261527
78	Fatty acid elongation_Homo sapiens_hsa00062	0.54259709
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53265414
80	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.53031157
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.52820076
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.51341241
83	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.51290320
84	RNA degradation_Homo sapiens_hsa03018	0.51223636
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50327848
86	Arginine biosynthesis_Homo sapiens_hsa00220	0.47817362
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.42565173
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.42295119
89	Ribosome_Homo sapiens_hsa03010	0.39805428
90	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.38855280
91	Bile secretion_Homo sapiens_hsa04976	0.38581515
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.35601634
93	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.34458304
94	Mineral absorption_Homo sapiens_hsa04978	0.33137343
95	Type II diabetes mellitus_Homo sapiens_hsa04930	0.32527818
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.32014224
97	Pancreatic secretion_Homo sapiens_hsa04972	0.31671817
98	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.29545900
99	Glutathione metabolism_Homo sapiens_hsa00480	0.28690698
100	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.28660506

LRRC37A11P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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