ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.84327363
2	protein targeting to Golgi (GO:0000042)	5.75442319
3	establishment of protein localization to Golgi (GO:0072600)	5.63516213
4	fusion of sperm to egg plasma membrane (GO:0007342)	5.58128333
5	acrosome reaction (GO:0007340)	5.55784398
6	sperm motility (GO:0030317)	5.49494653
7	plasma membrane fusion (GO:0045026)	4.34021827
8	response to pheromone (GO:0019236)	4.29724418
9	sperm capacitation (GO:0048240)	4.08357429
10	protein localization to Golgi apparatus (GO:0034067)	3.99466577
11	protein polyglutamylation (GO:0018095)	3.75434950
12	multicellular organism reproduction (GO:0032504)	3.49876658
13	intra-Golgi vesicle-mediated transport (GO:0006891)	3.42331814
14	Golgi to endosome transport (GO:0006895)	3.38546302
15	calcium ion-dependent exocytosis (GO:0017156)	3.28032685
16	regulation of cilium movement (GO:0003352)	3.27612935
17	positive regulation of Rab GTPase activity (GO:0032851)	3.23720154
18	regulation of Rab GTPase activity (GO:0032313)	3.23720154
19	cilium or flagellum-dependent cell motility (GO:0001539)	3.18731179
20	reproduction (GO:0000003)	3.17772236
21	axonemal dynein complex assembly (GO:0070286)	3.13201250
22	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.06657321
23	positive regulation of receptor recycling (GO:0001921)	3.01781918
24	phosphatidylethanolamine metabolic process (GO:0046337)	3.01393200
25	macroautophagy (GO:0016236)	2.97861410
26	sexual reproduction (GO:0019953)	2.81342662
27	regulation of T-helper 2 cell differentiation (GO:0045628)	2.81233745
28	regulation of interleukin-13 production (GO:0032656)	2.79954569
29	regulation of establishment of cell polarity (GO:2000114)	2.76404561
30	motile cilium assembly (GO:0044458)	2.73671941
31	regulation of integrin-mediated signaling pathway (GO:2001044)	2.73296523
32	centriole replication (GO:0007099)	2.72899099
33	spermatid nucleus differentiation (GO:0007289)	2.72892734
34	microtubule severing (GO:0051013)	2.71444086
35	vesicle transport along microtubule (GO:0047496)	2.70584777
36	cell wall macromolecule catabolic process (GO:0016998)	2.66064902
37	microtubule depolymerization (GO:0007019)	2.63508262
38	hepatocyte apoptotic process (GO:0097284)	2.61557764
39	RNA destabilization (GO:0050779)	2.57574614
40	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.53449318
41	microtubule nucleation (GO:0007020)	2.52433476
42	spermatid development (GO:0007286)	2.51636390
43	positive regulation of endothelial cell differentiation (GO:0045603)	2.51172799
44	response to epinephrine (GO:0071871)	2.47844088
45	cell wall macromolecule metabolic process (GO:0044036)	2.46334782
46	seminiferous tubule development (GO:0072520)	2.45842593
47	sperm-egg recognition (GO:0035036)	2.45165196
48	epithelial cilium movement (GO:0003351)	2.44950021
49	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.44786114
50	spermatogenesis (GO:0007283)	2.44122631
51	male gamete generation (GO:0048232)	2.42675447
52	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.40696192
53	microtubule polymerization or depolymerization (GO:0031109)	2.39543950
54	cilium movement (GO:0003341)	2.37485801
55	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.32514734
56	growth hormone receptor signaling pathway (GO:0060396)	2.30210673
57	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.29152656
58	cellular response to epinephrine stimulus (GO:0071872)	2.25222542
59	thrombin receptor signaling pathway (GO:0070493)	2.22978915
60	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.22415538
61	gamete generation (GO:0007276)	2.21147662
62	coronary vasculature morphogenesis (GO:0060977)	2.20527123
63	regulation of receptor recycling (GO:0001919)	2.19808601
64	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.19588756
65	organelle transport along microtubule (GO:0072384)	2.19212389
66	DNA packaging (GO:0006323)	2.16548560
67	single fertilization (GO:0007338)	2.16545059
68	termination of G-protein coupled receptor signaling pathway (GO:0038032)	2.16204165
69	ketone body metabolic process (GO:1902224)	2.15639649
70	sialylation (GO:0097503)	2.15347041
71	peptide catabolic process (GO:0043171)	2.13976938
72	regulation of microtubule-based movement (GO:0060632)	2.13337465
73	regulation of centriole replication (GO:0046599)	2.12692271
74	termination of signal transduction (GO:0023021)	2.12491915
75	receptor recycling (GO:0001881)	2.08035142
76	interleukin-6-mediated signaling pathway (GO:0070102)	2.06554498
77	regulation of clathrin-mediated endocytosis (GO:2000369)	2.06062314
78	early endosome to late endosome transport (GO:0045022)	2.06035861
79	negative regulation of inclusion body assembly (GO:0090084)	2.05215089
80	single strand break repair (GO:0000012)	2.04946831
81	calcium ion import (GO:0070509)	2.02457575
82	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	2.01993555
83	negative regulation of Rho protein signal transduction (GO:0035024)	2.01320237
84	fibroblast migration (GO:0010761)	1.98630812
85	cell-cell recognition (GO:0009988)	1.98519498
86	positive regulation of glycolytic process (GO:0045821)	1.98463298
87	regulation of protein localization to cell surface (GO:2000008)	1.98055098
88	centriole assembly (GO:0098534)	1.98005318
89	cellular response to growth hormone stimulus (GO:0071378)	1.97439979
90	heparin metabolic process (GO:0030202)	1.94599328
91	heparin biosynthetic process (GO:0030210)	1.94599328
92	peptidyl-threonine dephosphorylation (GO:0035970)	1.94516766
93	regulation of endothelial cell differentiation (GO:0045601)	1.93942129
94	actin filament capping (GO:0051693)	1.91962490
95	actin cytoskeleton reorganization (GO:0031532)	1.90187536
96	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	1.89983318
97	negative regulation of protein localization to cell surface (GO:2000009)	1.88856413
98	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	1.88846655
99	regulation of transcription involved in cell fate commitment (GO:0060850)	1.87967619
100	regulation of platelet aggregation (GO:0090330)	1.87890603

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	2.81805278
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.77352895
3	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.52502931
4	ZNF217_24962896_ChIP-Seq_MCF-7_Human	2.46195837
5	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.40345198
6	ER_23166858_ChIP-Seq_MCF-7_Human	2.27067873
7	ARNT_22903824_ChIP-Seq_MCF-7_Human	2.12966889
8	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.12893224
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.07118705
10	AHR_22903824_ChIP-Seq_MCF-7_Human	1.99610873
11	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.84129349
12	TAF15_26573619_Chip-Seq_HEK293_Human	1.83883897
13	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.80258757
14	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72640336
15	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.63380284
16	CBP_20019798_ChIP-Seq_JUKART_Human	1.63380284
17	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.62779769
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.61579127
19	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.59792425
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57954822
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.57236070
22	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54436949
23	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.54114183
24	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.54019233
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53024535
26	STAT3_23295773_ChIP-Seq_U87_Human	1.50776001
27	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.50585851
28	AR_25329375_ChIP-Seq_VCAP_Human	1.43570425
29	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42898711
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42714401
31	FUS_26573619_Chip-Seq_HEK293_Human	1.39236842
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.37537871
33	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36406674
34	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.36220815
35	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.35593053
36	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.35558498
37	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.35133385
38	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.32940819
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31671802
40	P300_19829295_ChIP-Seq_ESCs_Human	1.31597536
41	CJUN_26792858_Chip-Seq_BT549_Human	1.30947423
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30497292
43	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.26598092
44	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.26083353
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25334153
46	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23840893
47	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.22017745
48	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.22017745
49	TCF4_23295773_ChIP-Seq_U87_Human	1.21866922
50	DROSHA_22980978_ChIP-Seq_HELA_Human	1.20550927
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.19799275
52	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19799275
53	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.19592477
54	TP53_18474530_ChIP-ChIP_U2OS_Human	1.19538969
55	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18588376
56	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17332621
57	KDM2B_26808549_Chip-Seq_REH_Human	1.15064739
58	AR_21572438_ChIP-Seq_LNCaP_Human	1.14854661
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14080114
60	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.13109875
61	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09844157
62	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09308885
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08240558
64	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.07199623
65	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.07058662
66	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06927070
67	RUNX_20019798_ChIP-Seq_JUKART_Human	1.04595855
68	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01757272
69	TP63_23658742_ChIP-Seq_EP156T_Human	1.01410776
70	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.99248707
71	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.98951022
72	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98877257
73	P53_22387025_ChIP-Seq_ESCs_Mouse	0.98437512
74	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.98409462
75	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.97846981
76	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97706107
77	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.97104014
78	VDR_22108803_ChIP-Seq_LS180_Human	0.96862516
79	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.96616141
80	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.96530770
81	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.96390574
82	VDR_24787735_ChIP-Seq_THP-1_Human	0.95376048
83	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.95364492
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.92801966
85	TBL1_22424771_ChIP-Seq_293T_Human	0.91453897
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.90518155
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.88400493
88	TP53_16413492_ChIP-PET_HCT116_Human	0.88255109
89	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.88239918
90	CDX2_22108803_ChIP-Seq_LS180_Human	0.87715558
91	BCAT_22108803_ChIP-Seq_LS180_Human	0.87559891
92	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.86944530
93	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.86587972
94	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.86457551
95	AR_19668381_ChIP-Seq_PC3_Human	0.85121697
96	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.85031949
97	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.85016581
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.83113429
99	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.82836425
100	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.82175087

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	5.18394343
2	MP0005248_abnormal_Harderian_gland	4.30482537
3	MP0009780_abnormal_chondrocyte_physiolo	3.81064224
4	MP0000569_abnormal_digit_pigmentation	3.00955380
5	MP0000015_abnormal_ear_pigmentation	2.51647974
6	MP0005464_abnormal_platelet_physiology	2.50698392
7	MP0004084_abnormal_cardiac_muscle	2.21606606
8	MP0000372_irregular_coat_pigmentation	2.21006525
9	MP0004510_myositis	2.18239752
10	MP0003878_abnormal_ear_physiology	2.16761345
11	MP0005377_hearing/vestibular/ear_phenot	2.16761345
12	MP0002877_abnormal_melanocyte_morpholog	2.11061117
13	MP0005408_hypopigmentation	2.07977642
14	MP0004484_altered_response_of	2.06357857
15	MP0004381_abnormal_hair_follicle	1.94198983
16	MP0005171_absent_coat_pigmentation	1.80083023
17	MP0004036_abnormal_muscle_relaxation	1.73524844
18	MP0000427_abnormal_hair_cycle	1.71144024
19	MP0002102_abnormal_ear_morphology	1.69894022
20	MP0005083_abnormal_biliary_tract	1.60202332
21	MP0000465_gastrointestinal_hemorrhage	1.58373946
22	MP0002822_catalepsy	1.56911591
23	MP0003698_abnormal_male_reproductive	1.55337725
24	MP0003300_gastrointestinal_ulcer	1.52922980
25	MP0003724_increased_susceptibility_to	1.49827338
26	MP0008004_abnormal_stomach_pH	1.49292655
27	MP0005167_abnormal_blood-brain_barrier	1.47048731
28	MP0005409_darkened_coat_color	1.44193836
29	MP0005075_abnormal_melanosome_morpholog	1.39632040
30	MP0000383_abnormal_hair_follicle	1.39568632
31	MP0003828_pulmonary_edema	1.37668348
32	MP0000371_diluted_coat_color	1.37106058
33	MP0004233_abnormal_muscle_weight	1.36436596
34	MP0006054_spinal_hemorrhage	1.28171059
35	MP0004130_abnormal_muscle_cell	1.27353828
36	MP0001968_abnormal_touch/_nociception	1.20274853
37	MP0005670_abnormal_white_adipose	1.19500878
38	MP0001765_abnormal_ion_homeostasis	1.17460474
39	MP0003183_abnormal_peptide_metabolism	1.17072753
40	MP0006138_congestive_heart_failure	1.16755500
41	MP0005646_abnormal_pituitary_gland	1.16315401
42	MP0005253_abnormal_eye_physiology	1.16093550
43	MP0001986_abnormal_taste_sensitivity	1.15593178
44	MP0002638_abnormal_pupillary_reflex	1.15325146
45	MP0005174_abnormal_tail_pigmentation	1.14635218
46	MP0009115_abnormal_fat_cell	1.12633148
47	MP0002127_abnormal_cardiovascular_syste	1.11873274
48	MP0003172_abnormal_lysosome_physiology	1.10929407
49	MP0002736_abnormal_nociception_after	1.10236368
50	MP0001879_abnormal_lymphatic_vessel	1.07053843
51	MP0008775_abnormal_heart_ventricle	1.06935812
52	MP0010678_abnormal_skin_adnexa	1.06901105
53	MP0001486_abnormal_startle_reflex	1.06331145
54	MP0002332_abnormal_exercise_endurance	1.04708863
55	MP0002971_abnormal_brown_adipose	1.04282726
56	MP0001929_abnormal_gametogenesis	1.03288232
57	MP0003045_fibrosis	1.03085210
58	MP0004859_abnormal_synaptic_plasticity	1.01742084
59	MP0003136_yellow_coat_color	1.01566554
60	MP0003879_abnormal_hair_cell	0.99315777
61	MP0003646_muscle_fatigue	0.96497450
62	MP0010329_abnormal_lipoprotein_level	0.93031976
63	MP0002009_preneoplasia	0.91101734
64	MP0005187_abnormal_penis_morphology	0.89174706
65	MP0004085_abnormal_heartbeat	0.89102668
66	MP0002735_abnormal_chemical_nociception	0.87685953
67	MP0002168_other_aberrant_phenotype	0.87230379
68	MP0005058_abnormal_lysosome_morphology	0.86962861
69	MP0003091_abnormal_cell_migration	0.86776507
70	MP0000230_abnormal_systemic_arterial	0.86623805
71	MP0003787_abnormal_imprinting	0.83885684
72	MP0000013_abnormal_adipose_tissue	0.82959393
73	MP0000534_abnormal_ureter_morphology	0.81572796
74	MP0005620_abnormal_muscle_contractility	0.80896942
75	MP0002269_muscular_atrophy	0.80686657
76	MP0001984_abnormal_olfaction	0.80045774
77	MP0005386_behavior/neurological_phenoty	0.78078615
78	MP0004924_abnormal_behavior	0.78078615
79	MP0004883_abnormal_blood_vessel	0.74980228
80	MP0002229_neurodegeneration	0.74271027
81	MP0001664_abnormal_digestion	0.72681371
82	MP0000249_abnormal_blood_vessel	0.72481365
83	MP0002909_abnormal_adrenal_gland	0.72064535
84	MP0001958_emphysema	0.71979596
85	MP0002972_abnormal_cardiac_muscle	0.70716725
86	MP0003656_abnormal_erythrocyte_physiolo	0.70371895
87	MP0005423_abnormal_somatic_nervous	0.67933772
88	MP0004215_abnormal_myocardial_fiber	0.67915490
89	MP0002067_abnormal_sensory_capabilities	0.67847951
90	MP0001270_distended_abdomen	0.67642905
91	MP0008874_decreased_physiological_sensi	0.67225479
92	MP0002095_abnormal_skin_pigmentation	0.67103672
93	MP0003632_abnormal_nervous_system	0.65116543
94	MP0003638_abnormal_response/metabolism_	0.64085725
95	MP0002998_abnormal_bone_remodeling	0.63766605
96	MP0000749_muscle_degeneration	0.60226410
97	MP0002161_abnormal_fertility/fecundity	0.59166558
98	MP0002118_abnormal_lipid_homeostasis	0.56991144
99	MP0000377_abnormal_hair_follicle	0.56972047
100	MP0005551_abnormal_eye_electrophysiolog	0.56942119

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	4.12621260
2	Asymmetric septal hypertrophy (HP:0001670)	3.85609448
3	Prolonged bleeding time (HP:0003010)	3.84286053
4	Menorrhagia (HP:0000132)	3.63304734
5	Increased mean platelet volume (HP:0011877)	3.46224933
6	Menstrual irregularities (HP:0000858)	3.46049390
7	Severe visual impairment (HP:0001141)	3.42516035
8	Papillary thyroid carcinoma (HP:0002895)	3.26663610
9	Hyperventilation (HP:0002883)	3.26641610
10	Gingival bleeding (HP:0000225)	3.22822187
11	Abnormal platelet volume (HP:0011876)	3.21331572
12	Absent/shortened dynein arms (HP:0200106)	3.20465500
13	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.20465500
14	Truncal obesity (HP:0001956)	3.08231005
15	Bilateral sensorineural hearing impairment (HP:0008619)	3.06956315
16	Hyperkalemia (HP:0002153)	3.05747851
17	Absent frontal sinuses (HP:0002688)	3.05184574
18	Blue irides (HP:0000635)	3.01281374
19	Petechiae (HP:0000967)	2.88010521
20	Resting tremor (HP:0002322)	2.86318623
21	Purpura (HP:0000979)	2.75060408
22	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.59976766
23	Absent speech (HP:0001344)	2.52899936
24	Abnormal ciliary motility (HP:0012262)	2.47572751
25	Insidious onset (HP:0003587)	2.44385437
26	Termporal pattern (HP:0011008)	2.44385437
27	Progressive sensorineural hearing impairment (HP:0000408)	2.43847846
28	Hyporeflexia of lower limbs (HP:0002600)	2.41598438
29	Abnormal respiratory motile cilium morphology (HP:0005938)	2.39714359
30	Abnormal respiratory epithelium morphology (HP:0012253)	2.39714359
31	Mitral stenosis (HP:0001718)	2.39378337
32	Hypoplastic ischia (HP:0003175)	2.37762086
33	Frequent falls (HP:0002359)	2.36738363
34	Male infertility (HP:0003251)	2.35133632
35	Epistaxis (HP:0000421)	2.34816164
36	Abnormality of the ischium (HP:0003174)	2.34581523
37	Cone-rod dystrophy (HP:0000548)	2.34018526
38	Progressive cerebellar ataxia (HP:0002073)	2.31937797
39	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.31790277
40	Infertility (HP:0000789)	2.30116104
41	Abnormality of macular pigmentation (HP:0008002)	2.20482580
42	Thyroid carcinoma (HP:0002890)	2.18635440
43	Bundle branch block (HP:0011710)	2.13769778
44	Neoplasm of the heart (HP:0100544)	2.13283178
45	Abnormal respiratory motile cilium physiology (HP:0012261)	2.10999508
46	Chronic hepatic failure (HP:0100626)	2.09715812
47	Tented upper lip vermilion (HP:0010804)	2.08195634
48	Aplasia/Hypoplasia of the macula (HP:0008059)	2.05399483
49	Tubulointerstitial abnormality (HP:0001969)	2.04284862
50	Macroorchidism (HP:0000053)	2.04159227
51	Albinism (HP:0001022)	2.03675085
52	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.03348956
53	Hypoplasia of the fovea (HP:0007750)	2.03348956
54	Testicular neoplasm (HP:0010788)	1.99686164
55	Papilledema (HP:0001085)	1.97463617
56	Congenital sensorineural hearing impairment (HP:0008527)	1.95082738
57	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.95011268
58	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.94916134
59	Hypoplasia of the iris (HP:0007676)	1.94283500
60	Abnormality of the frontal sinuses (HP:0002687)	1.91912892
61	Decreased central vision (HP:0007663)	1.90186270
62	Long toe (HP:0010511)	1.89561056
63	Abnormality of the left ventricular outflow tract (HP:0011103)	1.89483719
64	Subaortic stenosis (HP:0001682)	1.89483719
65	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.87933566
66	Cutaneous melanoma (HP:0012056)	1.86036137
67	Generalized hypopigmentation (HP:0007513)	1.86031000
68	Stage 5 chronic kidney disease (HP:0003774)	1.81049987
69	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.80879929
70	Drooling (HP:0002307)	1.80034980
71	Postural instability (HP:0002172)	1.78882663
72	Widely spaced teeth (HP:0000687)	1.78084983
73	Genetic anticipation (HP:0003743)	1.77449444
74	Abnormal auditory evoked potentials (HP:0006958)	1.75888579
75	Insulin-resistant diabetes mellitus (HP:0000831)	1.74023297
76	Abnormality of the fovea (HP:0000493)	1.73072696
77	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.72779723
78	Abnormality of dental color (HP:0011073)	1.72352227
79	Curly hair (HP:0002212)	1.70988030
80	Portal hypertension (HP:0001409)	1.68316914
81	Open mouth (HP:0000194)	1.68279293
82	Excessive salivation (HP:0003781)	1.67817801
83	Protuberant abdomen (HP:0001538)	1.65925825
84	Hypoplasia of the thymus (HP:0000778)	1.65714720
85	Poikilocytosis (HP:0004447)	1.64902945
86	Horizontal nystagmus (HP:0000666)	1.64250419
87	Dyschromatopsia (HP:0007641)	1.61877359
88	Intellectual disability, moderate (HP:0002342)	1.61838133
89	Heterochromia iridis (HP:0001100)	1.61011009
90	Hyperlipoproteinemia (HP:0010980)	1.59427986
91	Ocular albinism (HP:0001107)	1.54168246
92	J-shaped sella turcica (HP:0002680)	1.54111569
93	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.52462945
94	Bruising susceptibility (HP:0000978)	1.51458774
95	Progressive hearing impairment (HP:0001730)	1.51322834
96	Abnormality of the hepatic vasculature (HP:0006707)	1.50647145
97	Failure to thrive in infancy (HP:0001531)	1.46587890
98	Abnormality of the renal cortex (HP:0011035)	1.46186897
99	Ankle clonus (HP:0011448)	1.45624228
100	Nasal polyposis (HP:0100582)	1.43936493

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA3	3.05404169
2	BRD4	2.49539709
3	PLK2	2.47737041
4	PLK4	2.43919728
5	TESK1	2.30810823
6	MAP4K2	2.26357305
7	MARK1	2.17680106
8	FER	2.14226300
9	STK38	2.04458420
10	SIK3	1.94021638
11	TRIM28	1.90403572
12	CASK	1.89449029
13	PTK2B	1.84009932
14	INSRR	1.80893080
15	EPHB1	1.75352494
16	ERBB3	1.73305841
17	PRKD3	1.72944710
18	BCR	1.66992552
19	MYLK	1.57684919
20	GRK6	1.57360728
21	PIK3CG	1.54977834
22	TXK	1.49551913
23	PNCK	1.47481016
24	DDR2	1.45625434
25	CAMK1G	1.41556532
26	FRK	1.37285388
27	OBSCN	1.34625104
28	NEK6	1.34413832
29	MARK3	1.29995248
30	PIK3CA	1.29197412
31	PDK1	1.28179424
32	LATS1	1.22479225
33	SGK2	1.21026991
34	PDPK1	1.14975922
35	LMTK2	1.11636914
36	JAK1	1.10791944
37	STK38L	1.09368801
38	EIF2AK1	1.08192462
39	MAP3K9	1.05079883
40	DYRK1B	0.97047420
41	SGK3	0.94704685
42	MAP3K4	0.92606654
43	SIK1	0.90354274
44	SGK494	0.88159906
45	SGK223	0.88159906
46	MAP2K1	0.86524911
47	AKT3	0.85901735
48	PKN2	0.84919827
49	TRIB3	0.84764866
50	MUSK	0.84274688
51	RET	0.81519567
52	FGFR3	0.80455024
53	SIK2	0.80450282
54	MST1R	0.78409763
55	ZAP70	0.78178387
56	MAP2K7	0.77615512
57	CSF1R	0.76866570
58	MAPK13	0.72965959
59	KSR1	0.72554514
60	PAK3	0.72182571
61	PHKG1	0.69981437
62	PHKG2	0.69981437
63	PINK1	0.69301605
64	ROCK1	0.65919231
65	CHUK	0.63674685
66	FGFR4	0.63392304
67	HCK	0.62022260
68	NEK9	0.61830977
69	PRKD1	0.61437171
70	PRKCE	0.61272512
71	IRAK1	0.60942181
72	RPS6KA4	0.58093295
73	PRKAA2	0.56875083
74	WNK1	0.56784993
75	PRKCZ	0.56577203
76	TNK2	0.56099103
77	CSNK1G2	0.55781985
78	RPS6KA2	0.54919192
79	KSR2	0.52638341
80	TTN	0.51606375
81	BLK	0.50305911
82	GRK5	0.49271553
83	JAK2	0.46797261
84	ERBB2	0.46150366
85	PRKG1	0.45771570
86	CSNK1D	0.44986440
87	SCYL2	0.44021950
88	CSNK1A1L	0.42334483
89	MAP2K2	0.41412776
90	CSNK1G3	0.41235404
91	TRPM7	0.40019925
92	BMPR2	0.39979554
93	MAP3K2	0.38817470
94	PDGFRB	0.38717011
95	PRKAA1	0.37451268
96	CAMK4	0.35583139
97	MAPKAPK3	0.34034641
98	YES1	0.32738415
99	HIPK2	0.31869360
100	MAP3K6	0.31488528

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.01899464
2	Platelet activation_Homo sapiens_hsa04611	1.95330654
3	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.49671662
4	Circadian rhythm_Homo sapiens_hsa04710	1.37909924
5	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.32296302
6	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.31392904
7	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.29736817
8	Endometrial cancer_Homo sapiens_hsa05213	1.26039206
9	Endocytosis_Homo sapiens_hsa04144	1.23222095
10	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.16078517
11	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.14739908
12	Olfactory transduction_Homo sapiens_hsa04740	1.14117018
13	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.09548117
14	Circadian entrainment_Homo sapiens_hsa04713	1.09116357
15	Choline metabolism in cancer_Homo sapiens_hsa05231	1.09029576
16	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.08613982
17	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.08595015
18	ABC transporters_Homo sapiens_hsa02010	1.05286213
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.05198327
20	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.04137285
21	Renin secretion_Homo sapiens_hsa04924	1.03977697
22	Gap junction_Homo sapiens_hsa04540	1.03769882
23	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.03718892
24	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.02951682
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.00516921
26	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.00512434
27	Non-small cell lung cancer_Homo sapiens_hsa05223	0.99635426
28	mTOR signaling pathway_Homo sapiens_hsa04150	0.99232048
29	GABAergic synapse_Homo sapiens_hsa04727	0.98142629
30	Focal adhesion_Homo sapiens_hsa04510	0.96074618
31	Morphine addiction_Homo sapiens_hsa05032	0.95926210
32	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.95366349
33	Insulin resistance_Homo sapiens_hsa04931	0.94961234
34	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.93526461
35	AMPK signaling pathway_Homo sapiens_hsa04152	0.93515673
36	Cholinergic synapse_Homo sapiens_hsa04725	0.92408657
37	Prolactin signaling pathway_Homo sapiens_hsa04917	0.92306948
38	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.91064069
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.89907525
40	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.89579282
41	Type II diabetes mellitus_Homo sapiens_hsa04930	0.86981869
42	Glutamatergic synapse_Homo sapiens_hsa04724	0.85293215
43	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.84299426
44	Renal cell carcinoma_Homo sapiens_hsa05211	0.84128553
45	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.83218220
46	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.82716094
47	Long-term potentiation_Homo sapiens_hsa04720	0.82575018
48	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.81348606
49	cAMP signaling pathway_Homo sapiens_hsa04024	0.81240857
50	Estrogen signaling pathway_Homo sapiens_hsa04915	0.81103738
51	Insulin signaling pathway_Homo sapiens_hsa04910	0.80246027
52	Butanoate metabolism_Homo sapiens_hsa00650	0.79666191
53	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.79256622
54	Long-term depression_Homo sapiens_hsa04730	0.79142097
55	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.79126470
56	Glioma_Homo sapiens_hsa05214	0.79075734
57	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.78504019
58	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.78211738
59	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.77584421
60	ECM-receptor interaction_Homo sapiens_hsa04512	0.77364484
61	Prostate cancer_Homo sapiens_hsa05215	0.77119697
62	PPAR signaling pathway_Homo sapiens_hsa03320	0.77042412
63	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.76801253
64	Chemokine signaling pathway_Homo sapiens_hsa04062	0.76122174
65	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.75547473
66	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.74999861
67	VEGF signaling pathway_Homo sapiens_hsa04370	0.74928883
68	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.74703871
69	Serotonergic synapse_Homo sapiens_hsa04726	0.72672323
70	Pancreatic secretion_Homo sapiens_hsa04972	0.71807770
71	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.71651925
72	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.71433558
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.71104069
74	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.71039658
75	Sphingolipid metabolism_Homo sapiens_hsa00600	0.70801868
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.69806413
77	Acute myeloid leukemia_Homo sapiens_hsa05221	0.69062297
78	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.69008126
79	Adherens junction_Homo sapiens_hsa04520	0.68008411
80	Dopaminergic synapse_Homo sapiens_hsa04728	0.67658973
81	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.66754487
82	Taste transduction_Homo sapiens_hsa04742	0.65793891
83	Amphetamine addiction_Homo sapiens_hsa05031	0.65180799
84	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.65171438
85	Pancreatic cancer_Homo sapiens_hsa05212	0.65170696
86	Axon guidance_Homo sapiens_hsa04360	0.63685980
87	FoxO signaling pathway_Homo sapiens_hsa04068	0.63475086
88	Melanoma_Homo sapiens_hsa05218	0.63394907
89	Salivary secretion_Homo sapiens_hsa04970	0.62530655
90	Gastric acid secretion_Homo sapiens_hsa04971	0.60881529
91	Osteoclast differentiation_Homo sapiens_hsa04380	0.60096874
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60084367
93	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.59607659
94	ErbB signaling pathway_Homo sapiens_hsa04012	0.59373345
95	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.58823248
96	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58544149
97	Tight junction_Homo sapiens_hsa04530	0.57825203
98	Regulation of autophagy_Homo sapiens_hsa04140	0.57401221
99	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.57355435
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57123838

LRRC37A16P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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