ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	7.62986360
2	protein targeting to Golgi (GO:0000042)	7.42944792
3	acrosome reaction (GO:0007340)	7.39958339
4	establishment of protein localization to Golgi (GO:0072600)	7.34153573
5	retrograde transport, vesicle recycling within Golgi (GO:0000301)	7.26324860
6	fusion of sperm to egg plasma membrane (GO:0007342)	6.46204208
7	microtubule depolymerization (GO:0007019)	5.90043132
8	chromosome condensation (GO:0030261)	5.73130122
9	DNA packaging (GO:0006323)	5.51929220
10	protein localization to Golgi apparatus (GO:0034067)	5.42795067
11	spermatid development (GO:0007286)	5.22421487
12	plasma membrane fusion (GO:0045026)	5.10516749
13	protein polyglutamylation (GO:0018095)	5.08016987
14	cilium or flagellum-dependent cell motility (GO:0001539)	4.98670730
15	response to pheromone (GO:0019236)	4.94715267
16	sperm capacitation (GO:0048240)	4.93944017
17	spermatid nucleus differentiation (GO:0007289)	4.93652426
18	microtubule polymerization or depolymerization (GO:0031109)	4.89497215
19	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.66395070
20	single strand break repair (GO:0000012)	4.65481852
21	axonemal dynein complex assembly (GO:0070286)	4.61841212
22	microtubule nucleation (GO:0007020)	4.58993645
23	phosphatidylethanolamine metabolic process (GO:0046337)	4.35984248
24	histone H3-K9 demethylation (GO:0033169)	4.33038580
25	sperm-egg recognition (GO:0035036)	4.31862581
26	microtubule severing (GO:0051013)	4.29393137
27	regulation of Rab GTPase activity (GO:0032313)	4.27155159
28	positive regulation of Rab GTPase activity (GO:0032851)	4.27155159
29	regulation of ARF GTPase activity (GO:0032312)	4.23643677
30	centriole replication (GO:0007099)	4.22867152
31	regulation of cilium movement (GO:0003352)	4.22620891
32	multicellular organism reproduction (GO:0032504)	4.13224504
33	spermatogenesis (GO:0007283)	4.11314308
34	male gamete generation (GO:0048232)	4.09954137
35	regulation of centriole replication (GO:0046599)	4.05676971
36	calcium ion-dependent exocytosis (GO:0017156)	4.03904228
37	rRNA methylation (GO:0031167)	4.00245237
38	histone H3-K9 methylation (GO:0051567)	3.96650020
39	reproduction (GO:0000003)	3.89910497
40	motile cilium assembly (GO:0044458)	3.88261174
41	binding of sperm to zona pellucida (GO:0007339)	3.85348729
42	gamete generation (GO:0007276)	3.80858115
43	sexual reproduction (GO:0019953)	3.78497681
44	nuclear pore complex assembly (GO:0051292)	3.76068143
45	Golgi to endosome transport (GO:0006895)	3.71870053
46	cell-cell recognition (GO:0009988)	3.68500087
47	centriole assembly (GO:0098534)	3.67572544
48	negative regulation of histone methylation (GO:0031061)	3.64877454
49	chromatin silencing (GO:0006342)	3.60988517
50	single fertilization (GO:0007338)	3.56825129
51	regulation of histone H3-K27 methylation (GO:0061085)	3.53982808
52	histone H3-K9 modification (GO:0061647)	3.51257013
53	nucleus organization (GO:0006997)	3.46916970
54	regulation of transcription involved in cell fate commitment (GO:0060850)	3.45121021
55	protein-DNA complex disassembly (GO:0032986)	3.41291172
56	nucleosome disassembly (GO:0006337)	3.41291172
57	epithelial cilium movement (GO:0003351)	3.39894468
58	negative regulation of gene expression, epigenetic (GO:0045814)	3.33915962
59	intra-Golgi vesicle-mediated transport (GO:0006891)	3.31538930
60	histone lysine demethylation (GO:0070076)	3.30826040
61	negative regulation of inclusion body assembly (GO:0090084)	3.27972005
62	germ cell development (GO:0007281)	3.21024569
63	fertilization (GO:0009566)	3.19916619
64	definitive hemopoiesis (GO:0060216)	3.18245605
65	RNA destabilization (GO:0050779)	3.17204223
66	histone demethylation (GO:0016577)	3.14024624
67	ventricular system development (GO:0021591)	3.12164204
68	multicellular organismal reproductive process (GO:0048609)	3.08606218
69	seminiferous tubule development (GO:0072520)	3.04364715
70	cilium movement (GO:0003341)	3.04012981
71	receptor recycling (GO:0001881)	3.03511674
72	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.01044426
73	histone H3-K36 demethylation (GO:0070544)	3.00956142
74	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.99667499
75	vesicle transport along microtubule (GO:0047496)	2.99510628
76	peptidyl-lysine trimethylation (GO:0018023)	2.95541833
77	peptidyl-threonine dephosphorylation (GO:0035970)	2.93614690
78	embryonic camera-type eye morphogenesis (GO:0048596)	2.93101831
79	nuclear pore organization (GO:0006999)	2.90555844
80	protein demethylation (GO:0006482)	2.90281071
81	protein dealkylation (GO:0008214)	2.90281071
82	poly(A)+ mRNA export from nucleus (GO:0016973)	2.90194504
83	glomerular visceral epithelial cell development (GO:0072015)	2.89618996
84	histone H4 deacetylation (GO:0070933)	2.89548286
85	cell wall macromolecule catabolic process (GO:0016998)	2.87005952
86	multicellular organismal movement (GO:0050879)	2.79049330
87	musculoskeletal movement (GO:0050881)	2.79049330
88	cell wall macromolecule metabolic process (GO:0044036)	2.76171924
89	protein K48-linked deubiquitination (GO:0071108)	2.72611731
90	histone lysine methylation (GO:0034968)	2.69185456
91	glomerular epithelial cell development (GO:0072310)	2.69114414
92	regulation of histone H3-K9 methylation (GO:0051570)	2.69105771
93	histone H3 deacetylation (GO:0070932)	2.68294504
94	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.67420896
95	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.66517924
96	DNA conformation change (GO:0071103)	2.65592927
97	cranial nerve morphogenesis (GO:0021602)	2.65464992
98	peptidyl-lysine dimethylation (GO:0018027)	2.63876874
99	peptidyl-lysine methylation (GO:0018022)	2.60841610
100	cornea development in camera-type eye (GO:0061303)	2.60233699

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.61877136
2	GBX2_23144817_ChIP-Seq_PC3_Human	2.38323923
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.25737942
4	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.25661271
5	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.25661271
6	DROSHA_22980978_ChIP-Seq_HELA_Human	2.20564751
7	ARNT_22903824_ChIP-Seq_MCF-7_Human	2.15826055
8	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.07495956
9	AHR_22903824_ChIP-Seq_MCF-7_Human	1.97126493
10	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.96064877
11	FUS_26573619_Chip-Seq_HEK293_Human	1.93877129
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.93731490
13	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.91563428
14	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.87591989
15	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.87197909
16	CBP_20019798_ChIP-Seq_JUKART_Human	1.87197909
17	GATA1_22025678_ChIP-Seq_K562_Human	1.85930018
18	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.79019373
19	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.77786372
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.76319838
21	STAT3_23295773_ChIP-Seq_U87_Human	1.75390240
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.73293971
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65068825
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.64139817
25	RUNX_20019798_ChIP-Seq_JUKART_Human	1.61480144
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.60620997
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57691712
28	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.55255712
29	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.49888854
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48612635
31	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.47685834
32	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.47301801
33	SCL_19346495_ChIP-Seq_HPC-7_Human	1.39606620
34	ZNF274_21170338_ChIP-Seq_K562_Hela	1.38269714
35	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.36874714
36	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.35009682
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.33174523
38	TCF4_23295773_ChIP-Seq_U87_Human	1.31117117
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29326946
40	IGF1R_20145208_ChIP-Seq_DFB_Human	1.28048952
41	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27377728
42	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.25020633
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23517558
44	AR_25329375_ChIP-Seq_VCAP_Human	1.23069645
45	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.21788162
46	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21235481
47	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.19082417
48	P300_19829295_ChIP-Seq_ESCs_Human	1.18926588
49	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.18454364
50	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.17749438
51	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.17293567
52	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17210263
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.17084644
54	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.15938971
55	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15691420
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14754251
57	AR_19668381_ChIP-Seq_PC3_Human	1.12928524
58	SPI1_23127762_ChIP-Seq_K562_Human	1.12287212
59	TBL1_22424771_ChIP-Seq_293T_Human	1.12153169
60	ERA_21632823_ChIP-Seq_H3396_Human	1.10923007
61	SMC4_20622854_ChIP-Seq_HELA_Human	1.10331922
62	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.09431830
63	KDM2B_26808549_Chip-Seq_REH_Human	1.08893023
64	RAC3_21632823_ChIP-Seq_H3396_Human	1.07301316
65	EZH2_22144423_ChIP-Seq_EOC_Human	1.07230829
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07041651
67	VDR_24787735_ChIP-Seq_THP-1_Human	1.04698496
68	TP53_18474530_ChIP-ChIP_U2OS_Human	1.04022709
69	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.03023181
70	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02764037
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01600370
72	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01134858
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00633320
74	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00610786
75	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.99944000
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.99047613
77	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.98869672
78	SMRT_27268052_Chip-Seq_Bcells_Human	0.98752147
79	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.98740590
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98695382
81	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98147736
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97830919
83	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.97799278
84	GATA3_27048872_Chip-Seq_THYMUS_Human	0.97366970
85	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97111769
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96086928
87	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.94912458
88	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.94663734
89	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.94447066
90	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.93280163
91	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.92695125
92	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.91231028
93	NFYB_21822215_ChIP-Seq_K562_Human	0.90552265
94	TP63_23658742_ChIP-Seq_EP156T_Human	0.89850438
95	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.89831933
96	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	0.89793057
97	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.88989941
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.86651584
99	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.86233879
100	MYB_26560356_Chip-Seq_TH2_Human	0.84221195

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.71855074
2	MP0005257_abnormal_intraocular_pressure	3.69173077
3	MP0003698_abnormal_male_reproductive	3.48142049
4	MP0005670_abnormal_white_adipose	3.04445515
5	MP0002638_abnormal_pupillary_reflex	3.04424471
6	MP0001929_abnormal_gametogenesis	3.04138875
7	MP0001348_abnormal_lacrimal_gland	2.94177969
8	MP0010386_abnormal_urinary_bladder	2.38329516
9	MP0008057_abnormal_DNA_replication	2.29226872
10	MP0003878_abnormal_ear_physiology	2.26049654
11	MP0005377_hearing/vestibular/ear_phenot	2.26049654
12	MP0004859_abnormal_synaptic_plasticity	2.03115900
13	MP0006292_abnormal_olfactory_placode	1.93309780
14	MP0002161_abnormal_fertility/fecundity	1.87387905
15	MP0008877_abnormal_DNA_methylation	1.82019458
16	MP0003172_abnormal_lysosome_physiology	1.80079983
17	MP0003787_abnormal_imprinting	1.72687503
18	MP0002009_preneoplasia	1.68995001
19	MP0000465_gastrointestinal_hemorrhage	1.65110382
20	MP0005451_abnormal_body_composition	1.61876228
21	MP0003091_abnormal_cell_migration	1.60914127
22	MP0002138_abnormal_hepatobiliary_system	1.57558857
23	MP0001486_abnormal_startle_reflex	1.49192928
24	MP0009697_abnormal_copulation	1.48551608
25	MP0005310_abnormal_salivary_gland	1.43952972
26	MP0000681_abnormal_thyroid_gland	1.42732300
27	MP0004808_abnormal_hematopoietic_stem	1.39873203
28	MP0000613_abnormal_salivary_gland	1.38302685
29	MP0002210_abnormal_sex_determination	1.32431615
30	MP0001145_abnormal_male_reproductive	1.22280861
31	MP0005499_abnormal_olfactory_system	1.21000324
32	MP0005394_taste/olfaction_phenotype	1.21000324
33	MP0004233_abnormal_muscle_weight	1.17519621
34	MP0000653_abnormal_sex_gland	1.10128239
35	MP0001835_abnormal_antigen_presentation	1.09465805
36	MP0002249_abnormal_larynx_morphology	1.07842321
37	MP0008789_abnormal_olfactory_epithelium	1.05717654
38	MP0002127_abnormal_cardiovascular_syste	1.05077066
39	MP0010368_abnormal_lymphatic_system	1.03729821
40	MP0001545_abnormal_hematopoietic_system	0.96165666
41	MP0005397_hematopoietic_system_phenotyp	0.96165666
42	MP0002160_abnormal_reproductive_system	0.95921197
43	MP0001270_distended_abdomen	0.93158896
44	MP0000955_abnormal_spinal_cord	0.89863114
45	MP0009278_abnormal_bone_marrow	0.89353640
46	MP0004036_abnormal_muscle_relaxation	0.89052467
47	MP0005423_abnormal_somatic_nervous	0.87851214
48	MP0009115_abnormal_fat_cell	0.85975920
49	MP0000678_abnormal_parathyroid_gland	0.85766045
50	MP0003763_abnormal_thymus_physiology	0.83620605
51	MP0003385_abnormal_body_wall	0.83579817
52	MP0000003_abnormal_adipose_tissue	0.82596403
53	MP0003879_abnormal_hair_cell	0.79673210
54	MP0008961_abnormal_basal_metabolism	0.77207758
55	MP0003935_abnormal_craniofacial_develop	0.77185527
56	MP0001963_abnormal_hearing_physiology	0.77042016
57	MP0005248_abnormal_Harderian_gland	0.76972387
58	MP0002735_abnormal_chemical_nociception	0.76868406
59	MP0000013_abnormal_adipose_tissue	0.74554128
60	MP0001661_extended_life_span	0.73798836
61	MP0010307_abnormal_tumor_latency	0.72104762
62	MP0005409_darkened_coat_color	0.71026678
63	MP0002396_abnormal_hematopoietic_system	0.70423906
64	MP0000569_abnormal_digit_pigmentation	0.69512307
65	MP0002282_abnormal_trachea_morphology	0.68578341
66	MP0001879_abnormal_lymphatic_vessel	0.68139560
67	MP0002229_neurodegeneration	0.67776025
68	MP0003115_abnormal_respiratory_system	0.67335651
69	MP0009384_cardiac_valve_regurgitation	0.66636325
70	MP0000733_abnormal_muscle_development	0.65598098
71	MP0002822_catalepsy	0.64833031
72	MP0000767_abnormal_smooth_muscle	0.64700930
73	MP0002925_abnormal_cardiovascular_devel	0.63437138
74	MP0003699_abnormal_female_reproductive	0.61903680
75	MP0003631_nervous_system_phenotype	0.61614746
76	MP0003632_abnormal_nervous_system	0.61359420
77	MP0005253_abnormal_eye_physiology	0.60009789
78	MP0000249_abnormal_blood_vessel	0.59424802
79	MP0002269_muscular_atrophy	0.59134825
80	MP0005084_abnormal_gallbladder_morpholo	0.58766277
81	MP0000703_abnormal_thymus_morphology	0.58321492
82	MP0003633_abnormal_nervous_system	0.57785909
83	MP0002108_abnormal_muscle_morphology	0.57741895
84	MP0002184_abnormal_innervation	0.57666590
85	MP0002928_abnormal_bile_duct	0.57607919
86	MP0002572_abnormal_emotion/affect_behav	0.56360632
87	MP0002971_abnormal_brown_adipose	0.56269749
88	MP0004484_altered_response_of	0.55439887
89	MP0003077_abnormal_cell_cycle	0.55354779
90	MP0000778_abnormal_nervous_system	0.55290491
91	MP0000534_abnormal_ureter_morphology	0.55134615
92	MP0003718_maternal_effect	0.54428319
93	MP0001614_abnormal_blood_vessel	0.54358762
94	MP0005464_abnormal_platelet_physiology	0.54287809
95	MP0002082_postnatal_lethality	0.54272678
96	MP0010770_preweaning_lethality	0.54272678
97	MP0003868_abnormal_feces_composition	0.53772650
98	MP0002067_abnormal_sensory_capabilities	0.53232653
99	MP0004084_abnormal_cardiac_muscle	0.52839697
100	MP0008569_lethality_at_weaning	0.52306848

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	5.63439222
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.26501317
3	Absent/shortened dynein arms (HP:0200106)	4.26501317
4	Chronic hepatic failure (HP:0100626)	4.15248088
5	Truncal obesity (HP:0001956)	3.52665293
6	Asymmetric septal hypertrophy (HP:0001670)	3.51623804
7	Hyperkalemia (HP:0002153)	3.42824747
8	Menstrual irregularities (HP:0000858)	3.31653377
9	Severe visual impairment (HP:0001141)	3.20799609
10	Renovascular hypertension (HP:0100817)	3.05520470
11	Hypoplasia of the thymus (HP:0000778)	3.05101077
12	Abnormal ciliary motility (HP:0012262)	3.02172138
13	Abnormality of the fingertips (HP:0001211)	2.98232518
14	Resting tremor (HP:0002322)	2.97872768
15	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.94499141
16	Cone-rod dystrophy (HP:0000548)	2.87518431
17	Abnormal respiratory motile cilium physiology (HP:0012261)	2.85129579
18	Abnormality of the aortic arch (HP:0012303)	2.82461772
19	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.78917538
20	Broad face (HP:0000283)	2.77911761
21	Male infertility (HP:0003251)	2.77296278
22	Progressive sensorineural hearing impairment (HP:0000408)	2.74975060
23	Abnormal respiratory epithelium morphology (HP:0012253)	2.65819542
24	Abnormal respiratory motile cilium morphology (HP:0005938)	2.65819542
25	Sandal gap (HP:0001852)	2.63075025
26	Volvulus (HP:0002580)	2.56474643
27	Attenuation of retinal blood vessels (HP:0007843)	2.56240979
28	Bell-shaped thorax (HP:0001591)	2.51714364
29	Progressive cerebellar ataxia (HP:0002073)	2.50926877
30	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.47233023
31	Insulin-resistant diabetes mellitus (HP:0000831)	2.45299307
32	Nasal polyposis (HP:0100582)	2.44878647
33	Hypoplastic ischia (HP:0003175)	2.41381568
34	Infertility (HP:0000789)	2.41028996
35	Urethral obstruction (HP:0000796)	2.34764039
36	Obsessive-compulsive behavior (HP:0000722)	2.30938655
37	Portal hypertension (HP:0001409)	2.30840318
38	Abnormality of the ischium (HP:0003174)	2.25198041
39	Long foot (HP:0001833)	2.18646155
40	Genetic anticipation (HP:0003743)	2.17669644
41	Enlarged epiphyses (HP:0010580)	2.15441315
42	Heterotopia (HP:0002282)	2.14295258
43	Tubulointerstitial abnormality (HP:0001969)	2.14286408
44	Stage 5 chronic kidney disease (HP:0003774)	2.13002161
45	Abnormality of macular pigmentation (HP:0008002)	2.12527817
46	Hypoglycemic seizures (HP:0002173)	2.11278047
47	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.09617548
48	Abnormality of the hepatic vasculature (HP:0006707)	2.07566526
49	Neoplasm of the heart (HP:0100544)	2.05920745
50	Colitis (HP:0002583)	2.01292236
51	Abnormality of the nasal mucosa (HP:0000433)	2.00928827
52	Postural instability (HP:0002172)	2.00898749
53	Abnormality of the parathyroid morphology (HP:0011766)	1.95780123
54	Accelerated skeletal maturation (HP:0005616)	1.94411110
55	Nephronophthisis (HP:0000090)	1.94055810
56	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	1.91896789
57	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.91085802
58	Hypoplasia of the fovea (HP:0007750)	1.91085802
59	Advanced eruption of teeth (HP:0006288)	1.88415558
60	Impulsivity (HP:0100710)	1.86303447
61	Difficulty running (HP:0009046)	1.85648663
62	Bony spicule pigmentary retinopathy (HP:0007737)	1.84565476
63	Spondylolisthesis (HP:0003302)	1.84391752
64	Abnormality of the renal medulla (HP:0100957)	1.84200924
65	Epiphyseal dysplasia (HP:0002656)	1.82741745
66	Elfin facies (HP:0004428)	1.81497220
67	Acute myeloid leukemia (HP:0004808)	1.81240325
68	Hepatitis (HP:0012115)	1.80433259
69	Poor coordination (HP:0002370)	1.79043343
70	Round face (HP:0000311)	1.78047486
71	Hypoalphalipoproteinemia (HP:0003233)	1.77054868
72	Optic nerve coloboma (HP:0000588)	1.76273684
73	Progressive hearing impairment (HP:0001730)	1.75266060
74	Abnormal spermatogenesis (HP:0008669)	1.74156411
75	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.74025462
76	Abnormality of the fovea (HP:0000493)	1.72909819
77	Convex nasal ridge (HP:0000444)	1.70852106
78	Abnormality of the epiphyses of the hand (HP:0005924)	1.68722409
79	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.68363114
80	Precocious puberty (HP:0000826)	1.66447729
81	Tapered finger (HP:0001182)	1.64653451
82	Intellectual disability, moderate (HP:0002342)	1.64548253
83	Pancreatic islet-cell hyperplasia (HP:0004510)	1.61271363
84	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.61224020
85	Germ cell neoplasia (HP:0100728)	1.60789524
86	Scanning speech (HP:0002168)	1.58610656
87	Abnormality of dental color (HP:0011073)	1.58097151
88	Agammaglobulinemia (HP:0004432)	1.54828313
89	Abnormality of potassium homeostasis (HP:0011042)	1.54516687
90	Hyperinsulinemic hypoglycemia (HP:0000825)	1.54028339
91	Narrow palate (HP:0000189)	1.53669603
92	Relative macrocephaly (HP:0004482)	1.53422466
93	Mask-like facies (HP:0000298)	1.53316857
94	Cubitus valgus (HP:0002967)	1.51230089
95	Abnormal rod and cone electroretinograms (HP:0008323)	1.50898786
96	Abnormality of lateral ventricle (HP:0030047)	1.50295968
97	Hip dysplasia (HP:0001385)	1.49066723
98	Short ribs (HP:0000773)	1.48481068
99	Abnormality of the pancreatic islet cells (HP:0006476)	1.47562448
100	Abnormality of endocrine pancreas physiology (HP:0012093)	1.47562448

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	INSRR	6.20797318
2	PLK4	5.06362333
3	BRD4	3.87393544
4	CDK12	3.82399846
5	CAMK1G	2.59860117
6	TRPM7	2.24186724
7	EEF2K	2.17385291
8	PTK2B	2.03316564
9	MAP4K2	2.02138025
10	PRKD3	1.98609495
11	PNCK	1.94755632
12	STK38	1.90562942
13	ICK	1.85224003
14	DDR2	1.76633662
15	NEK9	1.73458720
16	PLK2	1.71171817
17	AKT3	1.68605049
18	NEK2	1.65008045
19	STK38L	1.61436632
20	TAOK3	1.54861302
21	SIK2	1.52745795
22	PIK3CG	1.47663209
23	WNK1	1.46779827
24	MAPK13	1.38004099
25	MST1R	1.29919130
26	TESK1	1.29617774
27	LATS1	1.24149350
28	FLT3	1.22595925
29	PKN2	1.21950253
30	TYRO3	1.20113397
31	PDK1	1.18159836
32	DYRK1B	1.17713321
33	CDK3	1.17152661
34	SGK2	1.03134638
35	TNK2	1.01759132
36	CAMK1D	1.00959731
37	MAP3K13	1.00538466
38	PDPK1	0.99885984
39	MARK2	0.99590917
40	MAP3K7	0.91379670
41	KIT	0.89197654
42	CDK7	0.84254119
43	MTOR	0.83552613
44	FES	0.82745420
45	PDGFRA	0.75463240
46	SGK494	0.75004955
47	SGK223	0.75004955
48	RPS6KA2	0.74951064
49	PINK1	0.74048163
50	SGK3	0.68875468
51	BTK	0.68503969
52	BLK	0.67381824
53	MAPK10	0.64637105
54	CAMK4	0.62221945
55	CDK9	0.61866534
56	MARK1	0.60749675
57	HIPK2	0.59479315
58	PRKAA2	0.57460866
59	JAK3	0.56169103
60	MAPK11	0.55147147
61	NEK6	0.54070585
62	RET	0.54036269
63	CAMK1	0.54032029
64	TEC	0.52710731
65	MAP4K1	0.51216581
66	KSR2	0.48795655
67	SYK	0.48192770
68	TRIB3	0.48184449
69	CSF1R	0.48141856
70	NTRK3	0.48050911
71	MAP3K4	0.47363769
72	CDK8	0.47347730
73	FRK	0.45471500
74	RPS6KB1	0.44940025
75	GSK3B	0.42530022
76	HCK	0.40897641
77	MAPK1	0.39928416
78	CDK4	0.39250162
79	PRKCH	0.38348975
80	WNK4	0.38139285
81	MAP2K4	0.37307753
82	PRKG1	0.37109654
83	FGFR3	0.36654530
84	CDK2	0.36359290
85	SGK1	0.35639845
86	CDK1	0.34342362
87	FER	0.33457446
88	PRKAA1	0.33122347
89	MAPK7	0.32371289
90	CHEK1	0.31337783
91	ATM	0.30360272
92	MET	0.30186104
93	ERBB3	0.29221253
94	MAP2K7	0.29058521
95	MAP3K10	0.28344155
96	RPS6KC1	0.27847221
97	RPS6KL1	0.27847221
98	NEK1	0.27655632
99	MAP2K3	0.27618045
100	PRKG2	0.27232943

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.84729856
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.19757318
3	Type II diabetes mellitus_Homo sapiens_hsa04930	1.89501029
4	Olfactory transduction_Homo sapiens_hsa04740	1.82045450
5	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.61033012
6	Lysine degradation_Homo sapiens_hsa00310	1.60384459
7	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.58229723
8	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.53562098
9	mTOR signaling pathway_Homo sapiens_hsa04150	1.51104977
10	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.44516546
11	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.43034819
12	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.35783174
13	Non-small cell lung cancer_Homo sapiens_hsa05223	1.30384148
14	Prolactin signaling pathway_Homo sapiens_hsa04917	1.25870850
15	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.25358353
16	Platelet activation_Homo sapiens_hsa04611	1.22070571
17	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.18843537
18	Acute myeloid leukemia_Homo sapiens_hsa05221	1.18058283
19	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.15042598
20	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.11719626
21	Salivary secretion_Homo sapiens_hsa04970	1.09991188
22	mRNA surveillance pathway_Homo sapiens_hsa03015	1.09958255
23	Endometrial cancer_Homo sapiens_hsa05213	1.08914935
24	Other glycan degradation_Homo sapiens_hsa00511	1.07513061
25	ABC transporters_Homo sapiens_hsa02010	1.07438314
26	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.06058835
27	Long-term potentiation_Homo sapiens_hsa04720	1.05811526
28	Choline metabolism in cancer_Homo sapiens_hsa05231	1.00990420
29	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.00970185
30	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.00891809
31	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.00712731
32	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.97177661
33	Taste transduction_Homo sapiens_hsa04742	0.95306887
34	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.95263575
35	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.95030331
36	Glioma_Homo sapiens_hsa05214	0.93390957
37	Estrogen signaling pathway_Homo sapiens_hsa04915	0.91201933
38	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.90914642
39	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.89272741
40	Insulin signaling pathway_Homo sapiens_hsa04910	0.87299068
41	VEGF signaling pathway_Homo sapiens_hsa04370	0.87277628
42	Prostate cancer_Homo sapiens_hsa05215	0.87075555
43	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.86399075
44	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.86279767
45	Insulin resistance_Homo sapiens_hsa04931	0.85589018
46	ErbB signaling pathway_Homo sapiens_hsa04012	0.84314943
47	Butanoate metabolism_Homo sapiens_hsa00650	0.83530615
48	Oocyte meiosis_Homo sapiens_hsa04114	0.82651160
49	Cholinergic synapse_Homo sapiens_hsa04725	0.82626867
50	Influenza A_Homo sapiens_hsa05164	0.82587694
51	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.81177874
52	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.80806978
53	Focal adhesion_Homo sapiens_hsa04510	0.78765669
54	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.76607759
55	Circadian entrainment_Homo sapiens_hsa04713	0.75983403
56	FoxO signaling pathway_Homo sapiens_hsa04068	0.74896074
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.74667576
58	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.74652047
59	Adherens junction_Homo sapiens_hsa04520	0.73632173
60	cAMP signaling pathway_Homo sapiens_hsa04024	0.73600417
61	Endocytosis_Homo sapiens_hsa04144	0.73275552
62	Hepatitis B_Homo sapiens_hsa05161	0.72642980
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.71911913
64	Calcium signaling pathway_Homo sapiens_hsa04020	0.71389902
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.70111186
66	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.70097256
67	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.68350149
68	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.68134800
69	Renin secretion_Homo sapiens_hsa04924	0.67387808
70	Gastric acid secretion_Homo sapiens_hsa04971	0.66838279
71	Type I diabetes mellitus_Homo sapiens_hsa04940	0.66797366
72	Viral myocarditis_Homo sapiens_hsa05416	0.66511514
73	MicroRNAs in cancer_Homo sapiens_hsa05206	0.65754915
74	RNA transport_Homo sapiens_hsa03013	0.65093916
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.64632686
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.64458998
77	Notch signaling pathway_Homo sapiens_hsa04330	0.64302352
78	Colorectal cancer_Homo sapiens_hsa05210	0.62924259
79	Measles_Homo sapiens_hsa05162	0.62434516
80	Allograft rejection_Homo sapiens_hsa05330	0.62410084
81	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.61315051
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61149532
83	Pancreatic cancer_Homo sapiens_hsa05212	0.58954032
84	Fanconi anemia pathway_Homo sapiens_hsa03460	0.58290918
85	ECM-receptor interaction_Homo sapiens_hsa04512	0.57680559
86	Herpes simplex infection_Homo sapiens_hsa05168	0.57241436
87	Insulin secretion_Homo sapiens_hsa04911	0.56270184
88	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.55141634
89	AMPK signaling pathway_Homo sapiens_hsa04152	0.54921555
90	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.53983670
91	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.52890384
92	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.52688995
93	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.51759704
94	Gap junction_Homo sapiens_hsa04540	0.50211177
95	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.47283181
96	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.45599349
97	MAPK signaling pathway_Homo sapiens_hsa04010	0.45282079
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44772000
99	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.44305412
100	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.44293111

LRRC37A17P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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