ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	8.70563944
2	acrosome reaction (GO:0007340)	8.34806585
3	fusion of sperm to egg plasma membrane (GO:0007342)	7.69756993
4	response to pheromone (GO:0019236)	7.53771066
5	establishment of protein localization to Golgi (GO:0072600)	7.11094285
6	protein targeting to Golgi (GO:0000042)	6.98357304
7	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.61456901
8	protein polyglutamylation (GO:0018095)	6.17534583
9	microtubule depolymerization (GO:0007019)	6.07275952
10	plasma membrane fusion (GO:0045026)	5.81628828
11	multicellular organism reproduction (GO:0032504)	5.75529691
12	sperm capacitation (GO:0048240)	5.73022781
13	spermatid development (GO:0007286)	5.66685749
14	single strand break repair (GO:0000012)	5.63595863
15	microtubule polymerization or depolymerization (GO:0031109)	5.52906795
16	axonemal dynein complex assembly (GO:0070286)	5.26325899
17	protein localization to Golgi apparatus (GO:0034067)	5.24924785
18	centriole replication (GO:0007099)	5.18260073
19	cilium or flagellum-dependent cell motility (GO:0001539)	5.16021615
20	sperm-egg recognition (GO:0035036)	5.12971548
21	DNA packaging (GO:0006323)	5.03786142
22	calcium ion-dependent exocytosis (GO:0017156)	5.02783625
23	chromosome condensation (GO:0030261)	4.93762024
24	regulation of cilium movement (GO:0003352)	4.90151985
25	reproduction (GO:0000003)	4.82445193
26	spermatid nucleus differentiation (GO:0007289)	4.81062040
27	epithelial cilium movement (GO:0003351)	4.69881802
28	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.66756708
29	rRNA methylation (GO:0031167)	4.59335537
30	spermatogenesis (GO:0007283)	4.58043700
31	male gamete generation (GO:0048232)	4.56990790
32	RNA destabilization (GO:0050779)	4.47223900
33	phosphatidylethanolamine metabolic process (GO:0046337)	4.45928674
34	centriole assembly (GO:0098534)	4.38276578
35	cilium movement (GO:0003341)	4.35865725
36	cell-cell recognition (GO:0009988)	4.31776846
37	regulation of Rab GTPase activity (GO:0032313)	4.29510100
38	positive regulation of Rab GTPase activity (GO:0032851)	4.29510100
39	microtubule severing (GO:0051013)	4.29237163
40	motile cilium assembly (GO:0044458)	4.25807548
41	gamete generation (GO:0007276)	4.25097672
42	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.20910864
43	regulation of centriole replication (GO:0046599)	4.02906551
44	microtubule nucleation (GO:0007020)	4.01402828
45	binding of sperm to zona pellucida (GO:0007339)	4.00505501
46	single fertilization (GO:0007338)	3.84393393
47	negative regulation of inclusion body assembly (GO:0090084)	3.75256401
48	seminiferous tubule development (GO:0072520)	3.73864425
49	multicellular organismal movement (GO:0050879)	3.64889005
50	musculoskeletal movement (GO:0050881)	3.64889005
51	negative regulation of Rho protein signal transduction (GO:0035024)	3.64074198
52	cellular ketone body metabolic process (GO:0046950)	3.59132447
53	rRNA modification (GO:0000154)	3.50876836
54	regulation of transcription involved in cell fate commitment (GO:0060850)	3.50574733
55	axoneme assembly (GO:0035082)	3.47469500
56	regulation of microtubule-based movement (GO:0060632)	3.36419899
57	germ cell development (GO:0007281)	3.33792770
58	multicellular organismal reproductive process (GO:0048609)	3.32638670
59	cell wall macromolecule catabolic process (GO:0016998)	3.31949542
60	fertilization (GO:0009566)	3.23516670
61	cell wall macromolecule metabolic process (GO:0044036)	3.22326404
62	ketone body metabolic process (GO:1902224)	3.17409097
63	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.14923125
64	Golgi to endosome transport (GO:0006895)	3.05183661
65	sexual reproduction (GO:0019953)	3.05151433
66	ventricular system development (GO:0021591)	3.02599612
67	cilium organization (GO:0044782)	2.99323437
68	DNA methylation involved in gamete generation (GO:0043046)	2.98646227
69	cilium assembly (GO:0042384)	2.97314833
70	chromatin silencing (GO:0006342)	2.96579676
71	intra-Golgi vesicle-mediated transport (GO:0006891)	2.93133916
72	spinal cord motor neuron differentiation (GO:0021522)	2.90696157
73	glomerular visceral epithelial cell development (GO:0072015)	2.88689465
74	histone H3-K9 demethylation (GO:0033169)	2.87656069
75	organic cation transport (GO:0015695)	2.85755915
76	membrane depolarization during action potential (GO:0086010)	2.80619492
77	vesicle transport along microtubule (GO:0047496)	2.79767081
78	piRNA metabolic process (GO:0034587)	2.76771365
79	glomerular epithelial cell development (GO:0072310)	2.76575539
80	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.67678654
81	peptidyl-threonine dephosphorylation (GO:0035970)	2.67228359
82	coenzyme catabolic process (GO:0009109)	2.65402264
83	urinary tract smooth muscle contraction (GO:0014848)	2.65052672
84	cranial nerve morphogenesis (GO:0021602)	2.64914902
85	detection of light stimulus involved in visual perception (GO:0050908)	2.61772233
86	detection of light stimulus involved in sensory perception (GO:0050962)	2.61772233
87	microtubule bundle formation (GO:0001578)	2.61674990
88	nucleus organization (GO:0006997)	2.60687383
89	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.59205707
90	protein K48-linked deubiquitination (GO:0071108)	2.58183383
91	centrosome duplication (GO:0051298)	2.58060157
92	histone mRNA catabolic process (GO:0071044)	2.54261331
93	male meiosis (GO:0007140)	2.51115126
94	cell recognition (GO:0008037)	2.50387780
95	acrosome assembly (GO:0001675)	2.49895025
96	appendage development (GO:0048736)	2.48112332
97	limb development (GO:0060173)	2.48112332
98	left/right axis specification (GO:0070986)	2.47019110
99	regulation of phosphoprotein phosphatase activity (GO:0043666)	2.47015302
100	photoreceptor cell maintenance (GO:0045494)	2.46280091

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.34772942
2	GBX2_23144817_ChIP-Seq_PC3_Human	2.68042345
3	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.46324602
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.40451802
5	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.31003602
6	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.31003602
7	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.30017447
8	FUS_26573619_Chip-Seq_HEK293_Human	2.24424264
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.20785281
10	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.08751084
11	CBP_20019798_ChIP-Seq_JUKART_Human	2.08751084
12	ER_23166858_ChIP-Seq_MCF-7_Human	2.07209100
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00748058
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.00509602
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.97705993
16	DROSHA_22980978_ChIP-Seq_HELA_Human	1.94173402
17	P300_19829295_ChIP-Seq_ESCs_Human	1.92607357
18	AR_21572438_ChIP-Seq_LNCaP_Human	1.90839463
19	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.88689835
20	VDR_22108803_ChIP-Seq_LS180_Human	1.78908279
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.77476676
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.74563937
23	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.73087206
24	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71650508
25	STAT3_23295773_ChIP-Seq_U87_Human	1.69977522
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.68606385
27	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.66950594
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.66044635
29	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.65102558
30	AR_25329375_ChIP-Seq_VCAP_Human	1.65032751
31	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.64144329
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.62345144
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.62016653
34	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.57997882
35	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.51055285
36	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.49980618
37	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.48482228
38	RUNX2_22187159_ChIP-Seq_PCA_Human	1.46551845
39	IGF1R_20145208_ChIP-Seq_DFB_Human	1.45836112
40	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.42345596
41	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40829972
42	TCF4_23295773_ChIP-Seq_U87_Human	1.40536714
43	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.39762227
44	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.39289206
45	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.38580125
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37870525
47	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.32942295
48	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.29646973
49	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.26368632
50	REST_21632747_ChIP-Seq_MESCs_Mouse	1.26290291
51	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.26208808
52	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.25931675
53	AHR_22903824_ChIP-Seq_MCF-7_Human	1.25192971
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25139265
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.25001870
56	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24162317
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.24028734
58	ERA_21632823_ChIP-Seq_H3396_Human	1.20632051
59	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.20578445
60	TP53_18474530_ChIP-ChIP_U2OS_Human	1.20577347
61	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.20315493
62	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19682708
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18124215
64	TBL1_22424771_ChIP-Seq_293T_Human	1.14933586
65	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.13678381
66	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.12539812
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12168598
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12168598
69	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.11692862
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.11156286
71	KDM2B_26808549_Chip-Seq_REH_Human	1.09807652
72	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.08370465
73	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.07929918
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07241517
75	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.07173952
76	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.06983571
77	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.06522517
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06345574
79	ETV1_20927104_ChIP-Seq_GIST48_Human	1.06207556
80	* MYC_19829295_ChIP-Seq_ESCs_Human	1.06190301
81	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.05790347
82	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.04890899
83	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.04537232
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.04214632
85	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.04161392
86	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.03984741
87	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.03959589
88	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03859323
89	NFYB_21822215_ChIP-Seq_K562_Human	1.03394034
90	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.02016932
91	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.01494456
92	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01023571
93	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.00658401
94	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99146209
95	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.98869996
96	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98314838
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.98172205
98	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.97866753
99	BCAT_22108803_ChIP-Seq_LS180_Human	0.97646506
100	OCT4_20526341_ChIP-Seq_ESCs_Human	0.96359235

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.77894695
2	MP0003878_abnormal_ear_physiology	3.92196927
3	MP0005377_hearing/vestibular/ear_phenot	3.92196927
4	MP0003698_abnormal_male_reproductive	3.23646426
5	MP0000569_abnormal_digit_pigmentation	3.07562386
6	MP0001929_abnormal_gametogenesis	2.74155799
7	MP0005670_abnormal_white_adipose	2.63261421
8	MP0003646_muscle_fatigue	2.45890144
9	MP0001486_abnormal_startle_reflex	2.32775747
10	MP0001968_abnormal_touch/_nociception	2.27158676
11	MP0001348_abnormal_lacrimal_gland	2.05432048
12	MP0005551_abnormal_eye_electrophysiolog	1.97415683
13	MP0008877_abnormal_DNA_methylation	1.95747203
14	MP0001485_abnormal_pinna_reflex	1.87460020
15	MP0002735_abnormal_chemical_nociception	1.82229383
16	MP0002653_abnormal_ependyma_morphology	1.81814231
17	MP0005423_abnormal_somatic_nervous	1.81122046
18	MP0004859_abnormal_synaptic_plasticity	1.77828042
19	MP0001984_abnormal_olfaction	1.76655324
20	MP0002161_abnormal_fertility/fecundity	1.65583144
21	MP0004742_abnormal_vestibular_system	1.65173134
22	MP0005253_abnormal_eye_physiology	1.54572554
23	MP0009745_abnormal_behavioral_response	1.49315328
24	MP0002282_abnormal_trachea_morphology	1.46193576
25	MP0005646_abnormal_pituitary_gland	1.45356116
26	MP0002572_abnormal_emotion/affect_behav	1.43912323
27	MP0002272_abnormal_nervous_system	1.42375381
28	MP0002210_abnormal_sex_determination	1.40887804
29	MP0002067_abnormal_sensory_capabilities	1.38433178
30	MP0003635_abnormal_synaptic_transmissio	1.36616582
31	MP0005310_abnormal_salivary_gland	1.34857624
32	MP0003880_abnormal_central_pattern	1.34642704
33	MP0003718_maternal_effect	1.33970259
34	MP0002234_abnormal_pharynx_morphology	1.32671206
35	MP0009046_muscle_twitch	1.31577588
36	MP0001963_abnormal_hearing_physiology	1.29909715
37	MP0003136_yellow_coat_color	1.29570132
38	MP0000955_abnormal_spinal_cord	1.28002425
39	MP0002736_abnormal_nociception_after	1.27732080
40	MP0005379_endocrine/exocrine_gland_phen	1.26411911
41	MP0002557_abnormal_social/conspecific_i	1.25748197
42	MP0001970_abnormal_pain_threshold	1.21169041
43	MP0002928_abnormal_bile_duct	1.20536520
44	MP0002733_abnormal_thermal_nociception	1.19073528
45	MP0000026_abnormal_inner_ear	1.18797774
46	MP0001145_abnormal_male_reproductive	1.17513368
47	MP0003879_abnormal_hair_cell	1.16119730
48	MP0000653_abnormal_sex_gland	1.15279037
49	MP0002249_abnormal_larynx_morphology	1.14899469
50	MP0000778_abnormal_nervous_system	1.12820340
51	MP0003011_delayed_dark_adaptation	1.10437842
52	MP0002822_catalepsy	1.10352682
53	MP0002063_abnormal_learning/memory/cond	1.10144446
54	MP0002064_seizures	1.09598275
55	MP0001501_abnormal_sleep_pattern	1.09542544
56	MP0002138_abnormal_hepatobiliary_system	1.09283768
57	MP0002229_neurodegeneration	1.05648341
58	MP0002734_abnormal_mechanical_nocicepti	1.04861933
59	MP0008995_early_reproductive_senescence	1.03968173
60	MP0002102_abnormal_ear_morphology	1.01704004
61	MP0005248_abnormal_Harderian_gland	0.98429628
62	MP0000427_abnormal_hair_cycle	0.98285197
63	MP0000631_abnormal_neuroendocrine_gland	0.95588894
64	MP0001765_abnormal_ion_homeostasis	0.92162979
65	MP0005174_abnormal_tail_pigmentation	0.92140966
66	MP0006292_abnormal_olfactory_placode	0.90697162
67	MP0008569_lethality_at_weaning	0.87762177
68	MP0008872_abnormal_physiological_respon	0.87684729
69	MP0006072_abnormal_retinal_apoptosis	0.87092789
70	MP0008057_abnormal_DNA_replication	0.86952599
71	MP0006276_abnormal_autonomic_nervous	0.86561325
72	MP0002882_abnormal_neuron_morphology	0.86131774
73	MP0000015_abnormal_ear_pigmentation	0.81183415
74	MP0005395_other_phenotype	0.80989109
75	MP0004924_abnormal_behavior	0.80482896
76	MP0005386_behavior/neurological_phenoty	0.80482896
77	MP0008961_abnormal_basal_metabolism	0.80462126
78	MP0002752_abnormal_somatic_nervous	0.78957650
79	MP0000534_abnormal_ureter_morphology	0.77921779
80	MP0004085_abnormal_heartbeat	0.77507131
81	MP0004142_abnormal_muscle_tone	0.76936987
82	MP0005391_vision/eye_phenotype	0.76907488
83	MP0003195_calcinosis	0.76110493
84	MP0001905_abnormal_dopamine_level	0.75043842
85	MP0002184_abnormal_innervation	0.74446427
86	MP0001986_abnormal_taste_sensitivity	0.74172819
87	MP0009115_abnormal_fat_cell	0.74046476
88	MP0003787_abnormal_imprinting	0.73365933
89	MP0001440_abnormal_grooming_behavior	0.72805058
90	MP0003137_abnormal_impulse_conducting	0.71212250
91	MP0001502_abnormal_circadian_rhythm	0.70635675
92	MP0000049_abnormal_middle_ear	0.69204718
93	MP0004043_abnormal_pH_regulation	0.67789947
94	MP0004484_altered_response_of	0.67643942
95	MP0003631_nervous_system_phenotype	0.66077858
96	MP0003633_abnormal_nervous_system	0.65508065
97	MP0002127_abnormal_cardiovascular_syste	0.65213018
98	MP0002837_dystrophic_cardiac_calcinosis	0.65001471
99	MP0004885_abnormal_endolymph	0.64880957
100	MP0008789_abnormal_olfactory_epithelium	0.64848803

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.48480666
2	Absent/shortened dynein arms (HP:0200106)	5.48480666
3	Severe visual impairment (HP:0001141)	5.45371391
4	Chronic hepatic failure (HP:0100626)	5.15612656
5	Tubulointerstitial nephritis (HP:0001970)	4.98494691
6	Abnormal ciliary motility (HP:0012262)	4.45746368
7	Attenuation of retinal blood vessels (HP:0007843)	4.26906583
8	Abnormal respiratory motile cilium physiology (HP:0012261)	4.20842296
9	Progressive cerebellar ataxia (HP:0002073)	4.20823347
10	Abnormal respiratory motile cilium morphology (HP:0005938)	4.06587245
11	Abnormal respiratory epithelium morphology (HP:0012253)	4.06587245
12	Nephronophthisis (HP:0000090)	3.93995795
13	Bony spicule pigmentary retinopathy (HP:0007737)	3.92430412
14	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.74691972
15	Abnormality of the renal medulla (HP:0100957)	3.58265365
16	Abnormality of macular pigmentation (HP:0008002)	3.41864982
17	Pancreatic cysts (HP:0001737)	3.28339965
18	Hyperkalemia (HP:0002153)	3.24276549
19	Genetic anticipation (HP:0003743)	3.19783521
20	Asymmetric septal hypertrophy (HP:0001670)	3.06287904
21	Pancreatic fibrosis (HP:0100732)	3.04487870
22	Hypoplastic ischia (HP:0003175)	3.00045157
23	Truncal obesity (HP:0001956)	2.99982587
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.91139279
25	Tubulointerstitial abnormality (HP:0001969)	2.84210902
26	Rhinitis (HP:0012384)	2.82703258
27	Amelogenesis imperfecta (HP:0000705)	2.79464570
28	Type II lissencephaly (HP:0007260)	2.79243330
29	Abnormality of the ischium (HP:0003174)	2.76287136
30	Tubular atrophy (HP:0000092)	2.70265965
31	Bell-shaped thorax (HP:0001591)	2.70226786
32	Cone-rod dystrophy (HP:0000548)	2.65568414
33	True hermaphroditism (HP:0010459)	2.64334435
34	Infertility (HP:0000789)	2.62959006
35	Abnormality of midbrain morphology (HP:0002418)	2.61237092
36	Molar tooth sign on MRI (HP:0002419)	2.61237092
37	Abnormal drinking behavior (HP:0030082)	2.61188544
38	Polydipsia (HP:0001959)	2.61188544
39	Male infertility (HP:0003251)	2.60176872
40	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.57642690
41	Abnormality of the renal cortex (HP:0011035)	2.52482732
42	Impulsivity (HP:0100710)	2.51814229
43	Stage 5 chronic kidney disease (HP:0003774)	2.50586750
44	Potter facies (HP:0002009)	2.46796636
45	Facial shape deformation (HP:0011334)	2.46796636
46	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.46017663
47	Cystic liver disease (HP:0006706)	2.43785823
48	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.42781472
49	Postural instability (HP:0002172)	2.35690830
50	Resting tremor (HP:0002322)	2.33759453
51	Enlarged epiphyses (HP:0010580)	2.33399315
52	Optic nerve hypoplasia (HP:0000609)	2.30761840
53	Cerebellar dysplasia (HP:0007033)	2.29426183
54	Decreased central vision (HP:0007663)	2.24482245
55	Polyuria (HP:0000103)	2.24018131
56	Gaze-evoked nystagmus (HP:0000640)	2.22729917
57	Abnormal urine output (HP:0012590)	2.21850283
58	Portal hypertension (HP:0001409)	2.15332014
59	Abnormality of the aortic arch (HP:0012303)	2.14639239
60	Febrile seizures (HP:0002373)	2.12226862
61	Hyperventilation (HP:0002883)	2.11809273
62	Medial flaring of the eyebrow (HP:0010747)	2.08519578
63	Abnormality of dental color (HP:0011073)	2.08313976
64	Bulbous nose (HP:0000414)	2.06878769
65	Pendular nystagmus (HP:0012043)	2.06563419
66	Abnormality of the hepatic vasculature (HP:0006707)	2.04179262
67	Nasal polyposis (HP:0100582)	2.03049952
68	Genital tract atresia (HP:0001827)	2.00678656
69	Occipital encephalocele (HP:0002085)	2.00546971
70	Menstrual irregularities (HP:0000858)	2.00439227
71	Congenital hepatic fibrosis (HP:0002612)	1.99296541
72	Poor coordination (HP:0002370)	1.98664884
73	Abnormality of potassium homeostasis (HP:0011042)	1.97353045
74	Abnormality of the pubic bones (HP:0003172)	1.96736061
75	Abnormality of renal excretion (HP:0011036)	1.94740612
76	Congenital sensorineural hearing impairment (HP:0008527)	1.93946423
77	Hypoplasia of the thymus (HP:0000778)	1.93438111
78	Atonic seizures (HP:0010819)	1.92637958
79	Vaginal atresia (HP:0000148)	1.92027953
80	Lissencephaly (HP:0001339)	1.91594813
81	Gait imbalance (HP:0002141)	1.89994206
82	Intellectual disability, moderate (HP:0002342)	1.89027752
83	Congenital stationary night blindness (HP:0007642)	1.87896874
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.87839929
85	Focal motor seizures (HP:0011153)	1.87384716
86	Anencephaly (HP:0002323)	1.87130626
87	Bronchiectasis (HP:0002110)	1.87015349
88	Postaxial foot polydactyly (HP:0001830)	1.84819634
89	Renal dysplasia (HP:0000110)	1.83477139
90	Abnormal spermatogenesis (HP:0008669)	1.82233339
91	Oligodactyly (hands) (HP:0001180)	1.77122820
92	Nephrogenic diabetes insipidus (HP:0009806)	1.76919925
93	Congenital primary aphakia (HP:0007707)	1.76122383
94	Horizontal nystagmus (HP:0000666)	1.74978351
95	Volvulus (HP:0002580)	1.74492411
96	Sclerocornea (HP:0000647)	1.72503551
97	Hypophosphatemic rickets (HP:0004912)	1.71117610
98	Absent speech (HP:0001344)	1.69571192
99	Osteomalacia (HP:0002749)	1.68036926
100	Azoospermia (HP:0000027)	1.66194855

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	5.72260052
2	INSRR	4.31139688
3	FRK	3.59854246
4	PNCK	3.58715728
5	BRD4	2.99997159
6	PLK2	2.60703771
7	DDR2	2.49732456
8	MAP4K2	2.36782146
9	CAMK1G	2.35842720
10	MAPK15	2.27265813
11	STK38L	2.21700309
12	STK38	2.11311834
13	BMPR1B	2.08868424
14	MARK1	2.08340460
15	AKT3	1.71214282
16	WNK1	1.59114063
17	PRKD3	1.55535875
18	TESK1	1.53140466
19	LATS1	1.50978242
20	PINK1	1.45636455
21	PIK3CG	1.45246821
22	TAOK3	1.41547552
23	CASK	1.36468913
24	PTK2B	1.27313982
25	MAPK13	1.26427458
26	WNK3	1.23961722
27	ADRBK2	1.22965621
28	ACVR1B	1.21564662
29	MAP3K4	1.21539121
30	SGK2	1.20443542
31	WNK4	1.16273678
32	STK39	1.05970468
33	SGK494	1.04926497
34	SGK223	1.04926497
35	NTRK3	1.04732843
36	TNIK	1.00215921
37	GRK1	0.99960717
38	NUAK1	0.97044131
39	OXSR1	0.95168393
40	CAMK1D	0.91746433
41	PDK1	0.88660147
42	CAMK1	0.87040511
43	TYRO3	0.85393393
44	CDK3	0.82445650
45	CAMK4	0.81079346
46	SIK2	0.79374294
47	CAMKK2	0.77497280
48	PDPK1	0.75569587
49	NEK6	0.74199985
50	BRSK2	0.74175134
51	MUSK	0.74089242
52	DYRK3	0.71032228
53	PRKAA2	0.67734696
54	PRKCG	0.66722924
55	PRKG1	0.63752790
56	MAP3K7	0.63270992
57	DAPK2	0.63246093
58	SGK3	0.63022196
59	PKN1	0.62755309
60	ZAK	0.61936686
61	TLK1	0.61004620
62	SGK1	0.59705475
63	MAP2K7	0.59331830
64	NTRK2	0.57378653
65	PRKCE	0.56290294
66	TNK2	0.54682715
67	DYRK1B	0.51583452
68	MAP2K2	0.47608397
69	STK11	0.47215624
70	PRKCZ	0.47137637
71	PAK3	0.47095721
72	CDK12	0.45193991
73	RPS6KA2	0.45072684
74	MAPK8	0.41739180
75	GSK3B	0.41435971
76	ROCK1	0.40775025
77	MST1R	0.39952264
78	DYRK2	0.39868805
79	DYRK1A	0.39736922
80	BLK	0.39218154
81	PRKAA1	0.38502372
82	FGFR2	0.37872694
83	EPHA4	0.36947155
84	MAP3K2	0.35718274
85	MAPK1	0.35067245
86	ERBB2	0.34669848
87	GRK6	0.34592317
88	STK3	0.34296368
89	CAMK2A	0.33996663
90	RPS6KA6	0.33946282
91	CHUK	0.33059102
92	MKNK2	0.33006858
93	MARK3	0.32890368
94	ADRBK1	0.32632477
95	TXK	0.32368183
96	NLK	0.31418450
97	MARK2	0.31396584
98	OBSCN	0.30855579
99	CDK1	0.29729254
100	RPS6KA1	0.29527767

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.01158804
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.72077121
3	Olfactory transduction_Homo sapiens_hsa04740	3.12381436
4	Nicotine addiction_Homo sapiens_hsa05033	2.67344926
5	Taste transduction_Homo sapiens_hsa04742	2.51055516
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.43520956
7	Phototransduction_Homo sapiens_hsa04744	2.33641471
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.93254387
9	Morphine addiction_Homo sapiens_hsa05032	1.86922366
10	Butanoate metabolism_Homo sapiens_hsa00650	1.81480233
11	Circadian entrainment_Homo sapiens_hsa04713	1.72076071
12	Glutamatergic synapse_Homo sapiens_hsa04724	1.71114208
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.61842129
14	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.56739227
15	ABC transporters_Homo sapiens_hsa02010	1.47846107
16	GABAergic synapse_Homo sapiens_hsa04727	1.42089523
17	Circadian rhythm_Homo sapiens_hsa04710	1.40846431
18	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.39385605
19	Salivary secretion_Homo sapiens_hsa04970	1.36881956
20	Insulin secretion_Homo sapiens_hsa04911	1.33258498
21	Calcium signaling pathway_Homo sapiens_hsa04020	1.32798659
22	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.28634064
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.28401017
24	Type II diabetes mellitus_Homo sapiens_hsa04930	1.27712885
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.23307445
26	cAMP signaling pathway_Homo sapiens_hsa04024	1.21566353
27	Cholinergic synapse_Homo sapiens_hsa04725	1.17192474
28	Serotonergic synapse_Homo sapiens_hsa04726	1.12301090
29	Amphetamine addiction_Homo sapiens_hsa05031	1.08282457
30	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.06479355
31	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.02973960
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01429397
33	Renin secretion_Homo sapiens_hsa04924	1.00616395
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.99731609
35	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.97476691
36	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.96837032
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96153506
38	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.94317247
39	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.92729365
40	Gastric acid secretion_Homo sapiens_hsa04971	0.90944024
41	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.90356016
42	Glycerolipid metabolism_Homo sapiens_hsa00561	0.90198748
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.87718289
44	Selenocompound metabolism_Homo sapiens_hsa00450	0.86960929
45	Cocaine addiction_Homo sapiens_hsa05030	0.86470621
46	Dopaminergic synapse_Homo sapiens_hsa04728	0.86182323
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.85294983
48	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.85052391
49	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.84135951
50	Estrogen signaling pathway_Homo sapiens_hsa04915	0.77651494
51	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.76623946
52	Long-term depression_Homo sapiens_hsa04730	0.73596807
53	MAPK signaling pathway_Homo sapiens_hsa04010	0.73161723
54	Basal transcription factors_Homo sapiens_hsa03022	0.72010166
55	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.71554825
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.67576950
57	Oocyte meiosis_Homo sapiens_hsa04114	0.67122292
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.66797446
59	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.66515284
60	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.65135688
61	Long-term potentiation_Homo sapiens_hsa04720	0.64399832
62	Fatty acid degradation_Homo sapiens_hsa00071	0.63958358
63	Lysine degradation_Homo sapiens_hsa00310	0.63556966
64	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.59058793
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58028698
66	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.57755427
67	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.57460872
68	Regulation of autophagy_Homo sapiens_hsa04140	0.57400103
69	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.57231657
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.55869282
71	Retinol metabolism_Homo sapiens_hsa00830	0.55818237
72	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.55111089
73	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.54442280
74	Choline metabolism in cancer_Homo sapiens_hsa05231	0.54373688
75	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.52904682
76	Axon guidance_Homo sapiens_hsa04360	0.52648444
77	Phenylalanine metabolism_Homo sapiens_hsa00360	0.51641335
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51160921
79	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.49864299
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.49058257
81	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.48785307
82	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.47915335
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.47110119
84	Pancreatic secretion_Homo sapiens_hsa04972	0.46501444
85	Alcoholism_Homo sapiens_hsa05034	0.45868843
86	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.45742915
87	Protein digestion and absorption_Homo sapiens_hsa04974	0.45708159
88	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.44273130
89	Prolactin signaling pathway_Homo sapiens_hsa04917	0.44166789
90	Bile secretion_Homo sapiens_hsa04976	0.43160627
91	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.43146779
92	Tryptophan metabolism_Homo sapiens_hsa00380	0.42716253
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.42574228
94	RNA transport_Homo sapiens_hsa03013	0.42203569
95	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.41464332
96	FoxO signaling pathway_Homo sapiens_hsa04068	0.40425643
97	Ether lipid metabolism_Homo sapiens_hsa00565	0.40062941
98	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.39592743
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37270425
100	Type I diabetes mellitus_Homo sapiens_hsa04940	0.36858663

LRRC37A3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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