LRRC37A4P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to Golgi (GO:0072600)6.10559177
2protein targeting to Golgi (GO:0000042)5.74743195
3retrograde transport, vesicle recycling within Golgi (GO:0000301)5.70463056
4sperm motility (GO:0030317)5.17518467
5histone H3-K36 demethylation (GO:0070544)4.95811830
6cilium or flagellum-dependent cell motility (GO:0001539)4.85593636
7microtubule depolymerization (GO:0007019)4.72482793
8histone H3-K4 trimethylation (GO:0080182)4.60430104
9nuclear pore complex assembly (GO:0051292)4.48641112
10acrosome reaction (GO:0007340)4.48068056
11centriole replication (GO:0007099)4.46309364
12DNA packaging (GO:0006323)4.30546838
13histone H3-K9 demethylation (GO:0033169)4.27357515
14chromosome condensation (GO:0030261)4.20843452
15microtubule polymerization or depolymerization (GO:0031109)4.15224512
16peptidyl-lysine trimethylation (GO:0018023)3.96422229
17histone H3-K9 methylation (GO:0051567)3.95354000
18protein localization to Golgi apparatus (GO:0034067)3.92109304
19negative regulation of histone methylation (GO:0031061)3.91847031
20centriole assembly (GO:0098534)3.83049499
21positive regulation of Rab GTPase activity (GO:0032851)3.75845155
22regulation of Rab GTPase activity (GO:0032313)3.75845155
23fusion of sperm to egg plasma membrane (GO:0007342)3.75490958
24chromatin silencing (GO:0006342)3.75424668
25histone lysine methylation (GO:0034968)3.74329037
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.72260675
27regulation of translation, ncRNA-mediated (GO:0045974)3.72260675
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.72260675
29microtubule nucleation (GO:0007020)3.71143597
30histone H3-K9 modification (GO:0061647)3.70279064
31monoubiquitinated protein deubiquitination (GO:0035520)3.69554921
32regulation of gamma-delta T cell differentiation (GO:0045586)3.68920189
33histone lysine demethylation (GO:0070076)3.64841542
34regulation of centriole replication (GO:0046599)3.63456709
35phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.60833685
36regulation of histone H3-K27 methylation (GO:0061085)3.60428844
37protein K48-linked deubiquitination (GO:0071108)3.59665832
38histone H3-K4 methylation (GO:0051568)3.50551858
39nuclear pore organization (GO:0006999)3.49378555
40protein polyglutamylation (GO:0018095)3.47528404
41spermatid development (GO:0007286)3.44155629
42cellular response to ethanol (GO:0071361)3.42878352
43histone demethylation (GO:0016577)3.42613713
44peptidyl-lysine methylation (GO:0018022)3.42274009
45negative regulation of gene expression, epigenetic (GO:0045814)3.40049119
46definitive hemopoiesis (GO:0060216)3.38051183
47Golgi to endosome transport (GO:0006895)3.35558428
48positive regulation of gamma-delta T cell activation (GO:0046645)3.34824389
49pre-miRNA processing (GO:0031054)3.33352836
50nucleus organization (GO:0006997)3.31449406
51single strand break repair (GO:0000012)3.29539897
52positive regulation of granulocyte differentiation (GO:0030854)3.27899076
53regulation of gamma-delta T cell activation (GO:0046643)3.24347920
54phosphatidylethanolamine biosynthetic process (GO:0006646)3.21684881
55multicellular organismal movement (GO:0050879)3.20627053
56musculoskeletal movement (GO:0050881)3.20627053
57pore complex assembly (GO:0046931)3.20027255
58axonemal dynein complex assembly (GO:0070286)3.19011634
59interkinetic nuclear migration (GO:0022027)3.14109533
60sperm capacitation (GO:0048240)3.13705462
61regulation of ARF GTPase activity (GO:0032312)3.11197657
62cytoplasmic mRNA processing body assembly (GO:0033962)3.07754817
63corticosteroid receptor signaling pathway (GO:0031958)3.04040119
64spermatid nucleus differentiation (GO:0007289)3.00673995
65mitotic sister chromatid cohesion (GO:0007064)2.99781064
66protein dealkylation (GO:0008214)2.97960757
67protein demethylation (GO:0006482)2.97960757
68negative regulation of inclusion body assembly (GO:0090084)2.96072793
69cilium movement (GO:0003341)2.94253938
70nucleosome disassembly (GO:0006337)2.94150655
71protein-DNA complex disassembly (GO:0032986)2.94150655
72cell wall macromolecule catabolic process (GO:0016998)2.93714173
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93160802
74histone mRNA catabolic process (GO:0071044)2.92980465
75phosphatidylethanolamine metabolic process (GO:0046337)2.92844657
76peptidyl-threonine dephosphorylation (GO:0035970)2.91941041
77regulation of histone H3-K9 methylation (GO:0051570)2.90709079
78motile cilium assembly (GO:0044458)2.90670273
79male gamete generation (GO:0048232)2.90279518
80spermatogenesis (GO:0007283)2.90065463
81negative thymic T cell selection (GO:0045060)2.89677027
82histone methylation (GO:0016571)2.89562306
83B cell receptor signaling pathway (GO:0050853)2.89344346
84negative T cell selection (GO:0043383)2.87790676
85regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.86252674
86positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.86252674
87phospholipid translocation (GO:0045332)2.83674797
88lipid translocation (GO:0034204)2.83674797
89centrosome duplication (GO:0051298)2.83204822
90glucocorticoid receptor signaling pathway (GO:0042921)2.82983295
91positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.81692650
92regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.81692650
93peptidyl-lysine dimethylation (GO:0018027)2.80327624
94regulation of B cell receptor signaling pathway (GO:0050855)2.79948282
95response to pheromone (GO:0019236)2.77106262
96gamete generation (GO:0007276)2.70930702
97RNA destabilization (GO:0050779)2.70202524
98cell wall macromolecule metabolic process (GO:0044036)2.69563005
99ventricular system development (GO:0021591)2.69183630
100multicellular organism reproduction (GO:0032504)2.67831236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78738242
2DROSHA_22980978_ChIP-Seq_HELA_Human2.73261015
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.69699323
4RUNX_20019798_ChIP-Seq_JUKART_Human2.43330679
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.37649847
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37530823
7SCL_19346495_ChIP-Seq_HPC-7_Human2.24993903
8EZH2_22144423_ChIP-Seq_EOC_Human2.24777342
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.22490920
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22490920
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13160167
12AR_21572438_ChIP-Seq_LNCaP_Human2.11423670
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.09624884
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93257370
15VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.89247882
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84533476
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83707367
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82823585
19MYB_26560356_Chip-Seq_TH2_Human1.81412936
20ARNT_22903824_ChIP-Seq_MCF-7_Human1.77725458
21TP63_19390658_ChIP-ChIP_HaCaT_Human1.69956128
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.68110940
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66834607
24STAT3_23295773_ChIP-Seq_U87_Human1.63179707
25AHR_22903824_ChIP-Seq_MCF-7_Human1.59320904
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57682040
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49585770
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48377415
29CBP_20019798_ChIP-Seq_JUKART_Human1.48377415
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48081720
31GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47988676
32MYC_22102868_ChIP-Seq_BL_Human1.46996892
33SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46539188
34ER_23166858_ChIP-Seq_MCF-7_Human1.45947310
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45498882
36GATA3_27048872_Chip-Seq_THYMUS_Human1.43850879
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43123401
38SPI1_23127762_ChIP-Seq_K562_Human1.42095424
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40057340
40MYB_26560356_Chip-Seq_TH1_Human1.40045603
41CTNNB1_20460455_ChIP-Seq_HCT116_Human1.39236937
42E2F7_22180533_ChIP-Seq_HELA_Human1.37018866
43VDR_24787735_ChIP-Seq_THP-1_Human1.33585579
44TCF4_23295773_ChIP-Seq_U87_Human1.33356308
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31147514
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30779755
47FUS_26573619_Chip-Seq_HEK293_Human1.29437252
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28972976
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26821968
50GBX2_23144817_ChIP-Seq_PC3_Human1.26704140
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21014738
52SMAD4_21799915_ChIP-Seq_A2780_Human1.19797641
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19379805
54TCF7_22412390_ChIP-Seq_EML_Mouse1.19015388
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18219129
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17622677
57ZNF274_21170338_ChIP-Seq_K562_Hela1.17249720
58SMRT_27268052_Chip-Seq_Bcells_Human1.14938632
59PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13605011
60CIITA_25753668_ChIP-Seq_RAJI_Human1.12638383
61FOXA2_19822575_ChIP-Seq_HepG2_Human1.12425297
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.09765346
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09684488
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08053574
65TAF15_26573619_Chip-Seq_HEK293_Human1.07663781
66CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06915950
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06017355
68AR_19668381_ChIP-Seq_PC3_Human1.05217334
69GATA3_26560356_Chip-Seq_TH2_Human1.04184725
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03786220
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03737876
72FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01131102
73UTX_26944678_Chip-Seq_JUKART_Human1.00816563
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.00569979
75TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.00088238
76KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99939392
77PIAS1_25552417_ChIP-Seq_VCAP_Human0.99609966
78AR_25329375_ChIP-Seq_VCAP_Human0.99477447
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99474853
80ESR1_20079471_ChIP-ChIP_T-47D_Human0.98378847
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97725396
82SMAD3_21741376_ChIP-Seq_EPCs_Human0.96959447
83EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96670001
84RUNX2_22187159_ChIP-Seq_PCA_Human0.96570581
85OCT1_27270436_Chip-Seq_PROSTATE_Human0.96108931
86KDM2B_26808549_Chip-Seq_REH_Human0.93942699
87GATA1_22025678_ChIP-Seq_K562_Human0.93420085
88VDR_24763502_ChIP-Seq_THP-1_Human0.93349669
89KDM2B_26808549_Chip-Seq_JURKAT_Human0.92588698
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92356049
91E2F1_17053090_ChIP-ChIP_MCF-7_Human0.92297022
92TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91916913
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.91651865
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91351186
95NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91203970
96RUNX1_27514584_Chip-Seq_MCF-7_Human0.90618628
97SOX2_21211035_ChIP-Seq_LN229_Gbm0.89593506
98RXR_22108803_ChIP-Seq_LS180_Human0.89078596
99KDM2B_26808549_Chip-Seq_DND41_Human0.89017179
100SMAD_19615063_ChIP-ChIP_OVARY_Human0.87335185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.65851375
2MP0008057_abnormal_DNA_replication4.30555688
3MP0005377_hearing/vestibular/ear_phenot3.22527847
4MP0003878_abnormal_ear_physiology3.22527847
5MP0000569_abnormal_digit_pigmentation2.86423947
6MP0003763_abnormal_thymus_physiology2.76744515
7MP0002009_preneoplasia2.67866479
8MP0001835_abnormal_antigen_presentation2.44688531
9MP0005310_abnormal_salivary_gland2.38763831
10MP0002396_abnormal_hematopoietic_system2.35463892
11MP0003698_abnormal_male_reproductive2.33393176
12MP0001348_abnormal_lacrimal_gland2.20795886
13MP0005670_abnormal_white_adipose2.19316949
14MP0001929_abnormal_gametogenesis2.04739985
15MP0004808_abnormal_hematopoietic_stem1.99377843
16MP0009278_abnormal_bone_marrow1.88939924
17MP0008961_abnormal_basal_metabolism1.87106580
18MP0001800_abnormal_humoral_immune1.86171627
19MP0003172_abnormal_lysosome_physiology1.78166770
20MP0003045_fibrosis1.76315211
21MP0000703_abnormal_thymus_morphology1.66683573
22MP0002166_altered_tumor_susceptibility1.60359691
23MP0010094_abnormal_chromosome_stability1.59136709
24MP0003183_abnormal_peptide_metabolism1.56001473
25MP0005076_abnormal_cell_differentiation1.54950024
26MP0010307_abnormal_tumor_latency1.54779371
27MP0002398_abnormal_bone_marrow1.54113175
28MP0005397_hematopoietic_system_phenotyp1.52477082
29MP0001545_abnormal_hematopoietic_system1.52477082
30MP0008877_abnormal_DNA_methylation1.46628133
31MP0004264_abnormal_extraembryonic_tissu1.46020169
32MP0008995_early_reproductive_senescence1.42205865
33MP0002822_catalepsy1.36902053
34MP0002928_abnormal_bile_duct1.35796837
35MP0004043_abnormal_pH_regulation1.32717630
36MP0003077_abnormal_cell_cycle1.30743257
37MP0002138_abnormal_hepatobiliary_system1.28526903
38MP0001486_abnormal_startle_reflex1.25633852
39MP0009115_abnormal_fat_cell1.24159102
40MP0002168_other_aberrant_phenotype1.21718817
41MP0002722_abnormal_immune_system1.21514977
42MP0005645_abnormal_hypothalamus_physiol1.20564708
43MP0002420_abnormal_adaptive_immunity1.18165423
44MP0000015_abnormal_ear_pigmentation1.17604224
45MP0003787_abnormal_imprinting1.16280646
46MP0005174_abnormal_tail_pigmentation1.16228395
47MP0005075_abnormal_melanosome_morpholog1.15924738
48MP0000689_abnormal_spleen_morphology1.15121906
49MP0001819_abnormal_immune_cell1.14927974
50MP0002723_abnormal_immune_serum1.13359008
51MP0002405_respiratory_system_inflammati1.12695551
52MP0001873_stomach_inflammation1.12573036
53MP0000716_abnormal_immune_system1.12275422
54MP0002161_abnormal_fertility/fecundity1.10762948
55MP0002452_abnormal_antigen_presenting1.10045223
56MP0001765_abnormal_ion_homeostasis1.06684623
57MP0005409_darkened_coat_color1.05936623
58MP0003943_abnormal_hepatobiliary_system1.04614726
59MP0001501_abnormal_sleep_pattern1.03450593
60MP0008569_lethality_at_weaning1.00225953
61MP0003866_abnormal_defecation0.99724588
62MP0004742_abnormal_vestibular_system0.98009411
63MP0003091_abnormal_cell_migration0.95483718
64MP0003632_abnormal_nervous_system0.94756267
65MP0002210_abnormal_sex_determination0.94715529
66MP0003111_abnormal_nucleus_morphology0.94176765
67MP0005671_abnormal_response_to0.93635805
68MP0001485_abnormal_pinna_reflex0.93044688
69MP0005220_abnormal_exocrine_pancreas0.90090210
70MP0003646_muscle_fatigue0.90080359
71MP0004381_abnormal_hair_follicle0.89671285
72MP0001145_abnormal_male_reproductive0.89669391
73MP0001790_abnormal_immune_system0.89529710
74MP0005387_immune_system_phenotype0.89529710
75MP0002429_abnormal_blood_cell0.86279329
76MP0002249_abnormal_larynx_morphology0.83049301
77MP0002006_tumorigenesis0.82403762
78MP0005666_abnormal_adipose_tissue0.81930053
79MP0000685_abnormal_immune_system0.81234055
80MP0000653_abnormal_sex_gland0.80542244
81MP0005025_abnormal_response_to0.78648978
82MP0005000_abnormal_immune_tolerance0.78108874
83MP0005395_other_phenotype0.77534806
84MP0005379_endocrine/exocrine_gland_phen0.77309499
85MP0002067_abnormal_sensory_capabilities0.74495512
86MP0002019_abnormal_tumor_incidence0.71002498
87MP0002419_abnormal_innate_immunity0.70127750
88MP0001270_distended_abdomen0.68653966
89MP0000470_abnormal_stomach_morphology0.68515426
90MP0003300_gastrointestinal_ulcer0.64292904
91MP0004947_skin_inflammation0.63669217
92MP0003252_abnormal_bile_duct0.63281869
93MP0003115_abnormal_respiratory_system0.63169520
94MP0002557_abnormal_social/conspecific_i0.63155778
95MP0001851_eye_inflammation0.63101562
96MP0000371_diluted_coat_color0.60002644
97MP0009046_muscle_twitch0.59702885
98MP0002970_abnormal_white_adipose0.59246594
99MP0001963_abnormal_hearing_physiology0.59111029
100MP0005621_abnormal_cell_physiology0.58117706

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)4.99272075
2Abnormality of the fingertips (HP:0001211)4.94038852
3Tubulointerstitial nephritis (HP:0001970)4.72796043
4Chronic hepatic failure (HP:0100626)4.10880999
5Progressive cerebellar ataxia (HP:0002073)3.93373785
6Truncal obesity (HP:0001956)3.88782802
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.32231214
8Hypoplasia of the thymus (HP:0000778)3.28262767
9Hyperkalemia (HP:0002153)3.26649922
10Dynein arm defect of respiratory motile cilia (HP:0012255)2.91583343
11Absent/shortened dynein arms (HP:0200106)2.91583343
12Volvulus (HP:0002580)2.81943746
13Sandal gap (HP:0001852)2.80286993
14Impulsivity (HP:0100710)2.78225208
15Colitis (HP:0002583)2.77379636
16Acute myeloid leukemia (HP:0004808)2.77202053
17Severe visual impairment (HP:0001141)2.72916030
18Abnormality of the columella (HP:0009929)2.65108407
19Cone-rod dystrophy (HP:0000548)2.59633545
20Gaze-evoked nystagmus (HP:0000640)2.56968640
21Obsessive-compulsive behavior (HP:0000722)2.54383619
22Long eyelashes (HP:0000527)2.52666649
23Acute lymphatic leukemia (HP:0006721)2.47082138
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46639864
25Prominent nose (HP:0000448)2.40001129
26Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.36364239
27Renovascular hypertension (HP:0100817)2.36083929
28Hypoplastic ischia (HP:0003175)2.34986980
29Chromsome breakage (HP:0040012)2.34897361
30Menstrual irregularities (HP:0000858)2.30324200
31Ectopic kidney (HP:0000086)2.27977288
32Narrow palate (HP:0000189)2.26049774
33Postural instability (HP:0002172)2.20320456
34Abnormality of the ischium (HP:0003174)2.19738580
35Agammaglobulinemia (HP:0004432)2.15837860
36Heterotopia (HP:0002282)2.14655869
37Tented upper lip vermilion (HP:0010804)2.14480896
38Abnormal ciliary motility (HP:0012262)2.14299243
39Panhypogammaglobulinemia (HP:0003139)2.14031624
40Aplasia/Hypoplasia of the earlobes (HP:0009906)2.10428070
41Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.10034815
42Tubulointerstitial abnormality (HP:0001969)2.09984152
43Abnormality of the pubic bones (HP:0003172)2.08902318
44Dysmetric saccades (HP:0000641)2.07102514
45Abnormality of the nasal septum (HP:0000419)2.05111375
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03699679
47Abnormality of the renal medulla (HP:0100957)2.01898957
48Inflammation of the large intestine (HP:0002037)2.00416787
49Abnormal respiratory motile cilium physiology (HP:0012261)1.96917897
50Broad face (HP:0000283)1.95310316
51Gingivitis (HP:0000230)1.95305306
52T lymphocytopenia (HP:0005403)1.94982109
53Abnormality of DNA repair (HP:0003254)1.91937904
54Protruding tongue (HP:0010808)1.91630972
55Gastrointestinal inflammation (HP:0004386)1.91096084
56Tapered finger (HP:0001182)1.89640705
57Supernumerary ribs (HP:0005815)1.89029679
58Portal hypertension (HP:0001409)1.86893115
59Resting tremor (HP:0002322)1.86877431
60Thyroiditis (HP:0100646)1.85320347
61Abnormality of the parathyroid morphology (HP:0011766)1.83620514
62Abnormal respiratory epithelium morphology (HP:0012253)1.82531195
63Abnormal respiratory motile cilium morphology (HP:0005938)1.82531195
64Abnormal delayed hypersensitivity skin test (HP:0002963)1.81908794
65Severe combined immunodeficiency (HP:0004430)1.79812462
66Recurrent bronchitis (HP:0002837)1.79447997
67Clubbing of toes (HP:0100760)1.79246060
68Dislocated radial head (HP:0003083)1.77515510
69Supernumerary bones of the axial skeleton (HP:0009144)1.77270757
70Abnormality of chloride homeostasis (HP:0011422)1.75687333
71Anal stenosis (HP:0002025)1.74576276
72Widely spaced teeth (HP:0000687)1.74221674
73Intellectual disability, moderate (HP:0002342)1.73245942
74Hyperventilation (HP:0002883)1.73237429
75Nephronophthisis (HP:0000090)1.72163345
76Trigonocephaly (HP:0000243)1.71925427
77Abnormality of T cell number (HP:0011839)1.71786533
78Recurrent fungal infections (HP:0002841)1.71648056
79Neonatal hypoglycemia (HP:0001998)1.71074048
80Abnormality of the hepatic vasculature (HP:0006707)1.70599607
81Papilledema (HP:0001085)1.70565303
82Thick eyebrow (HP:0000574)1.70535151
83Progressive sensorineural hearing impairment (HP:0000408)1.69349769
84Abnormality of the aortic arch (HP:0012303)1.68921059
85Recurrent cutaneous fungal infections (HP:0011370)1.68648173
86Chronic mucocutaneous candidiasis (HP:0002728)1.68648173
87Bronchiectasis (HP:0002110)1.68081708
88Abnormality of chromosome stability (HP:0003220)1.67550626
89Nasal polyposis (HP:0100582)1.67486055
90Impaired smooth pursuit (HP:0007772)1.67035235
91Bronchitis (HP:0012387)1.66966731
92Germ cell neoplasia (HP:0100728)1.66266001
93Aplasia/Hypoplasia of the sternum (HP:0006714)1.65806823
94Recurrent viral infections (HP:0004429)1.64141678
95Underdeveloped nasal alae (HP:0000430)1.63569223
96Stereotypic behavior (HP:0000733)1.63470909
97Abnormality of the radial head (HP:0003995)1.61815264
98Obstructive sleep apnea (HP:0002870)1.61506465
99Bell-shaped thorax (HP:0001591)1.60126031
100Abnormal hair whorl (HP:0010721)1.59523755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.65157052
2PLK43.79879973
3BRD43.78417564
4INSRR3.52715384
5CAMK1G3.09906968
6TAOK32.92250644
7CAMK1D2.55042394
8FRK2.47493739
9SIK22.03029743
10WNK12.02001578
11MAP3K101.74642307
12TNK21.64219278
13BLK1.63462864
14MAP4K11.61587103
15AKT31.52996940
16MARK21.45600822
17PIK3CG1.44358100
18SGK21.44085461
19ICK1.37361232
20PNCK1.36802805
21BTK1.32631009
22STK381.31392497
23FGFR31.15248250
24TYRO31.14688855
25TRIB31.14453570
26MAP3K71.10611182
27CAMK41.09283144
28SGK4941.08713026
29SGK2231.08713026
30TEC1.08507096
31MTOR1.06428969
32EEF2K1.06342136
33MAPK151.05579619
34NLK1.03269904
35NEK21.02611378
36PDK11.01276714
37SGK31.01108295
38RIPK41.00281095
39MAP4K21.00129135
40SYK1.00035088
41KIT0.95467432
42CAMKK10.93756698
43BMPR1B0.92216097
44PRPF4B0.89233279
45ITK0.88495176
46MAPK110.87792926
47FES0.87224457
48CDK40.86464219
49CDK30.82716775
50SGK10.82036421
51TXK0.80840470
52PLK20.79812780
53FGFR20.78853983
54MAP3K40.74408660
55NEK60.71217063
56TRPM70.70420434
57ZAP700.70375555
58JAK10.70124997
59LATS10.69926164
60PRKD30.68221445
61ATR0.68183353
62MAP3K130.67083126
63STK38L0.66796592
64HCK0.66520478
65MKNK20.66380244
66PDPK10.66327007
67CDC42BPA0.66248840
68RET0.66219344
69CHEK10.65761162
70MARK30.64535376
71JAK30.63372854
72CSF1R0.62711116
73FGFR40.61557472
74CAMK10.61167718
75MST1R0.60917152
76PRKCH0.60701618
77PKN20.58437211
78MELK0.57858517
79NTRK20.56624911
80CDK20.56452367
81PRKAA20.55479507
82LCK0.55217447
83PTK2B0.54664853
84GSK3B0.54046116
85CDK70.53467544
86CDC70.52009011
87MAPK10.51556732
88ATM0.50870464
89MAPK100.50460710
90IKBKE0.50214035
91DYRK1B0.49693670
92CDK10.49621566
93MAPK80.47711125
94CDK60.46326527
95PASK0.45888444
96WNK40.45164723
97GRK60.44472368
98ACVR1B0.43315139
99TYK20.42832944
100CHUK0.41372632

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.25845730
2B cell receptor signaling pathway_Homo sapiens_hsa046622.09823843
3Fatty acid biosynthesis_Homo sapiens_hsa000611.97002434
4Phosphatidylinositol signaling system_Homo sapiens_hsa040701.75476500
5Non-small cell lung cancer_Homo sapiens_hsa052231.70201314
6Primary immunodeficiency_Homo sapiens_hsa053401.66535282
7Acute myeloid leukemia_Homo sapiens_hsa052211.57592980
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56725868
9T cell receptor signaling pathway_Homo sapiens_hsa046601.56316987
10Dorso-ventral axis formation_Homo sapiens_hsa043201.51776903
11Inositol phosphate metabolism_Homo sapiens_hsa005621.43024480
12Type II diabetes mellitus_Homo sapiens_hsa049301.39480178
13Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28344137
14Notch signaling pathway_Homo sapiens_hsa043301.27277831
15Taste transduction_Homo sapiens_hsa047421.26692553
16Choline metabolism in cancer_Homo sapiens_hsa052311.26355254
17Olfactory transduction_Homo sapiens_hsa047401.26042353
18Thyroid hormone signaling pathway_Homo sapiens_hsa049191.24832207
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24087898
20Graft-versus-host disease_Homo sapiens_hsa053321.23704415
21Prostate cancer_Homo sapiens_hsa052151.21350568
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21252183
23mTOR signaling pathway_Homo sapiens_hsa041501.16227607
24Platelet activation_Homo sapiens_hsa046111.15330013
25Chronic myeloid leukemia_Homo sapiens_hsa052201.14802550
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14772536
27Autoimmune thyroid disease_Homo sapiens_hsa053201.14745049
28Influenza A_Homo sapiens_hsa051641.14681196
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.11947533
30Fanconi anemia pathway_Homo sapiens_hsa034601.10535658
31Allograft rejection_Homo sapiens_hsa053301.09112790
32Prolactin signaling pathway_Homo sapiens_hsa049171.06911115
33Long-term potentiation_Homo sapiens_hsa047201.06529462
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05426995
35Pancreatic cancer_Homo sapiens_hsa052121.03840114
36VEGF signaling pathway_Homo sapiens_hsa043701.03677075
37Cholinergic synapse_Homo sapiens_hsa047251.02680708
38Colorectal cancer_Homo sapiens_hsa052101.01894247
39ErbB signaling pathway_Homo sapiens_hsa040121.00873186
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.00847366
41FoxO signaling pathway_Homo sapiens_hsa040681.00464286
42Endometrial cancer_Homo sapiens_hsa052131.00254794
43Glycerophospholipid metabolism_Homo sapiens_hsa005640.99701985
44NF-kappa B signaling pathway_Homo sapiens_hsa040640.99637557
45Measles_Homo sapiens_hsa051620.98637962
46Osteoclast differentiation_Homo sapiens_hsa043800.97712921
47MicroRNAs in cancer_Homo sapiens_hsa052060.96312514
48Herpes simplex infection_Homo sapiens_hsa051680.96041437
49mRNA surveillance pathway_Homo sapiens_hsa030150.95699173
50ABC transporters_Homo sapiens_hsa020100.93814727
51Salivary secretion_Homo sapiens_hsa049700.92901477
52Glioma_Homo sapiens_hsa052140.92322942
53Hepatitis B_Homo sapiens_hsa051610.91347719
54Estrogen signaling pathway_Homo sapiens_hsa049150.90438810
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89689431
56Type I diabetes mellitus_Homo sapiens_hsa049400.88940492
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87322898
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.85844766
59Leishmaniasis_Homo sapiens_hsa051400.84748722
60Glutamatergic synapse_Homo sapiens_hsa047240.84557827
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83704280
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83420180
63Antigen processing and presentation_Homo sapiens_hsa046120.82909797
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79930033
65Non-homologous end-joining_Homo sapiens_hsa034500.79573597
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78853725
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.78019963
68Renal cell carcinoma_Homo sapiens_hsa052110.77190029
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76545707
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76061243
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74836978
72Calcium signaling pathway_Homo sapiens_hsa040200.71303476
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70524989
74Toxoplasmosis_Homo sapiens_hsa051450.69103759
75MAPK signaling pathway_Homo sapiens_hsa040100.67316577
76cAMP signaling pathway_Homo sapiens_hsa040240.66091102
77Long-term depression_Homo sapiens_hsa047300.65713608
78Chemokine signaling pathway_Homo sapiens_hsa040620.64126776
79Oxytocin signaling pathway_Homo sapiens_hsa049210.63899528
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63520492
81Viral carcinogenesis_Homo sapiens_hsa052030.62948561
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.61586492
83Circadian entrainment_Homo sapiens_hsa047130.61000625
84GnRH signaling pathway_Homo sapiens_hsa049120.60701611
85Nicotine addiction_Homo sapiens_hsa050330.60211674
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.59731438
87Viral myocarditis_Homo sapiens_hsa054160.59383435
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59037913
89Insulin resistance_Homo sapiens_hsa049310.58987173
90Gastric acid secretion_Homo sapiens_hsa049710.58668826
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58590763
92HTLV-I infection_Homo sapiens_hsa051660.58212442
93Adherens junction_Homo sapiens_hsa045200.57712385
94Morphine addiction_Homo sapiens_hsa050320.56964889
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56582308
96Asthma_Homo sapiens_hsa053100.56513315
97Hematopoietic cell lineage_Homo sapiens_hsa046400.55207045
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54673048
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.53734777
100Pancreatic secretion_Homo sapiens_hsa049720.52572818

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