ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of telomere maintenance (GO:0032205)	6.18082477
2	nonmotile primary cilium assembly (GO:0035058)	5.19083268
3	behavioral response to nicotine (GO:0035095)	5.02897304
4	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.43637325
5	regulation of telomere maintenance via telomerase (GO:0032210)	4.32916981
6	epithelial cilium movement (GO:0003351)	4.08471046
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.05108102
8	regulation of telomere maintenance (GO:0032204)	3.98146205
9	somite development (GO:0061053)	3.66482086
10	platelet dense granule organization (GO:0060155)	3.64646872
11	indolalkylamine metabolic process (GO:0006586)	3.63714482
12	substrate-independent telencephalic tangential migration (GO:0021826)	3.61982746
13	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.61982746
14	DNA damage response, detection of DNA damage (GO:0042769)	3.56257026
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.53767284
16	detection of light stimulus involved in visual perception (GO:0050908)	3.53767284
17	response to pheromone (GO:0019236)	3.49457908
18	L-fucose catabolic process (GO:0042355)	3.48814635
19	fucose catabolic process (GO:0019317)	3.48814635
20	L-fucose metabolic process (GO:0042354)	3.48814635
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.44943501
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.44943501
23	NADH dehydrogenase complex assembly (GO:0010257)	3.44943501
24	axoneme assembly (GO:0035082)	3.44713122
25	protein localization to cilium (GO:0061512)	3.44703603
26	indole-containing compound catabolic process (GO:0042436)	3.39759092
27	indolalkylamine catabolic process (GO:0046218)	3.39759092
28	tryptophan catabolic process (GO:0006569)	3.39759092
29	regulation of cilium movement (GO:0003352)	3.38936790
30	negative regulation of telomerase activity (GO:0051974)	3.36447322
31	kynurenine metabolic process (GO:0070189)	3.36169482
32	protein complex biogenesis (GO:0070271)	3.32475814
33	cilium morphogenesis (GO:0060271)	3.30226524
34	cilium movement (GO:0003341)	3.27487038
35	DNA deamination (GO:0045006)	3.25032029
36	sulfation (GO:0051923)	3.21642295
37	C4-dicarboxylate transport (GO:0015740)	3.15360591
38	regulation of action potential (GO:0098900)	3.08612354
39	brain morphogenesis (GO:0048854)	3.07927589
40	neuron cell-cell adhesion (GO:0007158)	3.07239650
41	presynaptic membrane assembly (GO:0097105)	3.04898555
42	protein polyglutamylation (GO:0018095)	3.03035544
43	respiratory chain complex IV assembly (GO:0008535)	2.99714392
44	mitochondrial respiratory chain complex assembly (GO:0033108)	2.99658959
45	synaptic transmission, cholinergic (GO:0007271)	2.97784878
46	water-soluble vitamin biosynthetic process (GO:0042364)	2.96187076
47	cilium organization (GO:0044782)	2.95663110
48	cilium assembly (GO:0042384)	2.93936685
49	transmission of nerve impulse (GO:0019226)	2.93793806
50	protein-cofactor linkage (GO:0018065)	2.92015662
51	indole-containing compound metabolic process (GO:0042430)	2.89233616
52	regulation of helicase activity (GO:0051095)	2.86486762
53	postsynaptic membrane organization (GO:0001941)	2.83822248
54	cilium or flagellum-dependent cell motility (GO:0001539)	2.82922260
55	preassembly of GPI anchor in ER membrane (GO:0016254)	2.82120348
56	intraciliary transport (GO:0042073)	2.80969536
57	photoreceptor cell development (GO:0042461)	2.80688161
58	DNA damage induced protein phosphorylation (GO:0006975)	2.80094858
59	alanine transport (GO:0032328)	2.78937994
60	reflex (GO:0060004)	2.77703584
61	serotonin metabolic process (GO:0042428)	2.77635799
62	presynaptic membrane organization (GO:0097090)	2.77107503
63	neuronal action potential (GO:0019228)	2.75508907
64	gamma-aminobutyric acid transport (GO:0015812)	2.73615212
65	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.72775126
66	glycerophospholipid catabolic process (GO:0046475)	2.72356387
67	piRNA metabolic process (GO:0034587)	2.72143032
68	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.70676361
69	cellular ketone body metabolic process (GO:0046950)	2.70541738
70	regulation of telomerase activity (GO:0051972)	2.69998151
71	left/right axis specification (GO:0070986)	2.66666308
72	photoreceptor cell maintenance (GO:0045494)	2.65301031
73	tryptophan metabolic process (GO:0006568)	2.65134623
74	lymphangiogenesis (GO:0001946)	2.64362266
75	retinal cone cell development (GO:0046549)	2.63908684
76	primary amino compound metabolic process (GO:1901160)	2.62136676
77	axonemal dynein complex assembly (GO:0070286)	2.61341334
78	pyrimidine nucleobase catabolic process (GO:0006208)	2.61282339
79	negative regulation of mast cell activation (GO:0033004)	2.61007499
80	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.60183260
81	cornea development in camera-type eye (GO:0061303)	2.60078876
82	retinal ganglion cell axon guidance (GO:0031290)	2.57257912
83	eye photoreceptor cell development (GO:0042462)	2.55394267
84	cell proliferation in forebrain (GO:0021846)	2.55191187
85	S-adenosylmethionine metabolic process (GO:0046500)	2.55167474
86	cellular response to ATP (GO:0071318)	2.53769471
87	neural tube formation (GO:0001841)	2.51248660
88	ketone body metabolic process (GO:1902224)	2.51060478
89	determination of left/right symmetry (GO:0007368)	2.49928915
90	cytochrome complex assembly (GO:0017004)	2.49172300
91	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.48612468
92	telomere maintenance via telomerase (GO:0007004)	2.48247244
93	replication fork processing (GO:0031297)	2.48217545
94	regulation of sarcomere organization (GO:0060297)	2.47851062
95	ubiquinone biosynthetic process (GO:0006744)	2.47635358
96	amine catabolic process (GO:0009310)	2.46950907
97	cellular biogenic amine catabolic process (GO:0042402)	2.46950907
98	tongue development (GO:0043586)	2.46329765
99	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.45441726
100	smoothened signaling pathway (GO:0007224)	2.45171282

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.60959166
2	VDR_22108803_ChIP-Seq_LS180_Human	3.51505264
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.44379049
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.26835087
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.22786709
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.90333597
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.85019414
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.65416985
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.44345296
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.30370070
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18898536
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.17785946
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14882657
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14647649
15	FUS_26573619_Chip-Seq_HEK293_Human	2.13787582
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.13397462
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.06443697
18	P300_19829295_ChIP-Seq_ESCs_Human	2.06234423
19	EWS_26573619_Chip-Seq_HEK293_Human	2.01770370
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.92931299
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.92656144
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.75311962
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.71981918
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70493821
25	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.70347679
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.63561104
27	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.62018945
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.59716935
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58511638
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57237817
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.57237817
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.55687692
33	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.55567073
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53840225
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53035728
36	STAT3_23295773_ChIP-Seq_U87_Human	1.51923991
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.50886519
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.50018521
39	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.49863782
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46993722
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.45538333
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45175372
43	REST_21632747_ChIP-Seq_MESCs_Mouse	1.44296884
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.43668135
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.43668135
46	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.43090899
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.42307939
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.42165097
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40859834
50	RNF2_27304074_Chip-Seq_NSC_Mouse	1.38660193
51	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37080974
52	AR_25329375_ChIP-Seq_VCAP_Human	1.36614200
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.36159490
54	ELK1_19687146_ChIP-ChIP_HELA_Human	1.34641192
55	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.34426295
56	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.34194633
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.33702293
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33267353
59	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.30212405
60	TCF4_23295773_ChIP-Seq_U87_Human	1.29951602
61	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.28434330
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26113449
63	NCOR_22424771_ChIP-Seq_293T_Human	1.24288330
64	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.23190724
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.22886723
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20919332
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20919332
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20451598
69	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.19570536
70	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.17700547
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17509277
72	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15130823
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12693806
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10943300
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10943300
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09503548
77	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09196362
78	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07812896
79	AR_20517297_ChIP-Seq_VCAP_Human	1.07421895
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.06711807
81	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06650618
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05761184
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05295780
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05212192
85	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.05107942
86	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05016839
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04665078
88	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03224604
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02378345
90	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02138934
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02049731
92	AR_21572438_ChIP-Seq_LNCaP_Human	1.01752449
93	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99414627
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99213859
95	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.98720331
96	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97970293
97	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.96263341
98	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95365320
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.94839809
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92919583

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.13836773
2	MP0003880_abnormal_central_pattern	2.95578188
3	MP0002163_abnormal_gland_morphology	2.58429941
4	MP0004133_heterotaxia	2.53878681
5	MP0003136_yellow_coat_color	2.53110158
6	MP0006292_abnormal_olfactory_placode	2.41553747
7	MP0005551_abnormal_eye_electrophysiolog	2.39932508
8	MP0003195_calcinosis	2.39245439
9	MP0002736_abnormal_nociception_after	2.33800228
10	MP0006276_abnormal_autonomic_nervous	2.32178832
11	MP0001968_abnormal_touch/_nociception	2.32166052
12	MP0008877_abnormal_DNA_methylation	2.20941594
13	MP0002876_abnormal_thyroid_physiology	2.04565476
14	MP0005379_endocrine/exocrine_gland_phen	1.98697088
15	MP0005646_abnormal_pituitary_gland	1.90484999
16	MP0006072_abnormal_retinal_apoptosis	1.88714783
17	MP0009745_abnormal_behavioral_response	1.87726796
18	MP0001984_abnormal_olfaction	1.85914217
19	MP0003787_abnormal_imprinting	1.84682542
20	MP0004147_increased_porphyrin_level	1.84650312
21	MP0008875_abnormal_xenobiotic_pharmacok	1.81391061
22	MP0002837_dystrophic_cardiac_calcinosis	1.79551120
23	MP0002653_abnormal_ependyma_morphology	1.78579719
24	MP0000569_abnormal_digit_pigmentation	1.76472117
25	MP0005253_abnormal_eye_physiology	1.74298552
26	MP0008789_abnormal_olfactory_epithelium	1.64786791
27	MP0001986_abnormal_taste_sensitivity	1.63506280
28	MP0000427_abnormal_hair_cycle	1.63213369
29	MP0000631_abnormal_neuroendocrine_gland	1.62812701
30	MP0000372_irregular_coat_pigmentation	1.59296537
31	MP0001529_abnormal_vocalization	1.56863322
32	MP0002734_abnormal_mechanical_nocicepti	1.49872155
33	MP0002272_abnormal_nervous_system	1.48333486
34	MP0004270_analgesia	1.47714422
35	MP0004885_abnormal_endolymph	1.44263115
36	MP0004142_abnormal_muscle_tone	1.44002421
37	MP0008872_abnormal_physiological_respon	1.43518368
38	MP0001485_abnormal_pinna_reflex	1.42926192
39	MP0005645_abnormal_hypothalamus_physiol	1.41355179
40	MP0004043_abnormal_pH_regulation	1.40521489
41	MP0009046_muscle_twitch	1.40314590
42	MP0002938_white_spotting	1.38618097
43	MP0001501_abnormal_sleep_pattern	1.37158145
44	MP0000778_abnormal_nervous_system	1.34962250
45	MP0002557_abnormal_social/conspecific_i	1.34162460
46	MP0002064_seizures	1.32781821
47	MP0001486_abnormal_startle_reflex	1.29212497
48	MP0003011_delayed_dark_adaptation	1.25197047
49	MP0002638_abnormal_pupillary_reflex	1.24243352
50	MP0000647_abnormal_sebaceous_gland	1.23641044
51	MP0003646_muscle_fatigue	1.21941811
52	MP0002735_abnormal_chemical_nociception	1.21697684
53	MP0002572_abnormal_emotion/affect_behav	1.19728254
54	MP0005195_abnormal_posterior_eye	1.19526687
55	MP0002234_abnormal_pharynx_morphology	1.19483302
56	MP0005174_abnormal_tail_pigmentation	1.15292627
57	MP0001970_abnormal_pain_threshold	1.15093664
58	MP0004145_abnormal_muscle_electrophysio	1.14809041
59	MP0002095_abnormal_skin_pigmentation	1.14685515
60	MP0005394_taste/olfaction_phenotype	1.14330087
61	MP0005499_abnormal_olfactory_system	1.14330087
62	MP0001324_abnormal_eye_pigmentation	1.13497249
63	MP0004742_abnormal_vestibular_system	1.13379036
64	MP0002254_reproductive_system_inflammat	1.12028651
65	MP0010386_abnormal_urinary_bladder	1.10757396
66	MP0003635_abnormal_synaptic_transmissio	1.09203845
67	MP0001293_anophthalmia	1.08397835
68	MP0002928_abnormal_bile_duct	1.07840107
69	MP0008995_early_reproductive_senescence	1.07298740
70	MP0005386_behavior/neurological_phenoty	1.05119114
71	MP0004924_abnormal_behavior	1.05119114
72	MP0002733_abnormal_thermal_nociception	1.03037103
73	MP0000026_abnormal_inner_ear	1.00464654
74	MP0002063_abnormal_learning/memory/cond	0.99275982
75	MP0003122_maternal_imprinting	0.98743954
76	MP0008775_abnormal_heart_ventricle	0.96186398
77	MP0002752_abnormal_somatic_nervous	0.95384609
78	MP0005084_abnormal_gallbladder_morpholo	0.94744535
79	MP0003878_abnormal_ear_physiology	0.93103308
80	MP0005377_hearing/vestibular/ear_phenot	0.93103308
81	MP0005423_abnormal_somatic_nervous	0.92806402
82	MP0005171_absent_coat_pigmentation	0.89884894
83	MP0005389_reproductive_system_phenotype	0.87968912
84	MP0002233_abnormal_nose_morphology	0.86925967
85	MP0005187_abnormal_penis_morphology	0.86532295
86	MP0001963_abnormal_hearing_physiology	0.86452705
87	MP0002067_abnormal_sensory_capabilities	0.85336474
88	MP0002751_abnormal_autonomic_nervous	0.84733048
89	MP0003950_abnormal_plasma_membrane	0.84702239
90	MP0002184_abnormal_innervation	0.84475200
91	MP0010030_abnormal_orbit_morphology	0.83120563
92	MP0005391_vision/eye_phenotype	0.82251149
93	MP0001905_abnormal_dopamine_level	0.82143231
94	MP0002909_abnormal_adrenal_gland	0.81176877
95	MP0005332_abnormal_amino_acid	0.79391165
96	MP0005075_abnormal_melanosome_morpholog	0.78904429
97	MP0003121_genomic_imprinting	0.77635314
98	MP0000230_abnormal_systemic_arterial	0.76401530
99	MP0000049_abnormal_middle_ear	0.74274066
100	MP0001919_abnormal_reproductive_system	0.73943216

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	5.28355848
2	Molar tooth sign on MRI (HP:0002419)	5.28355848
3	Pancreatic cysts (HP:0001737)	4.75177060
4	Pancreatic fibrosis (HP:0100732)	4.69031550
5	True hermaphroditism (HP:0010459)	4.52921774
6	Nephronophthisis (HP:0000090)	4.01940533
7	Medial flaring of the eyebrow (HP:0010747)	3.54105797
8	Congenital stationary night blindness (HP:0007642)	3.48211292
9	Chronic hepatic failure (HP:0100626)	3.35756843
10	Hyperventilation (HP:0002883)	3.29368682
11	Abnormality of the renal medulla (HP:0100957)	3.27543341
12	Abnormality of the renal cortex (HP:0011035)	3.15694127
13	Cystic liver disease (HP:0006706)	3.02012949
14	Pendular nystagmus (HP:0012043)	3.01398844
15	Gait imbalance (HP:0002141)	2.92964717
16	Abolished electroretinogram (ERG) (HP:0000550)	2.92429299
17	Type II lissencephaly (HP:0007260)	2.92255373
18	Sclerocornea (HP:0000647)	2.90859242
19	Congenital primary aphakia (HP:0007707)	2.83537769
20	Esophageal atresia (HP:0002032)	2.79220209
21	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.71812143
22	Tubular atrophy (HP:0000092)	2.69020610
23	Attenuation of retinal blood vessels (HP:0007843)	2.68624171
24	Anencephaly (HP:0002323)	2.64737811
25	Renal cortical cysts (HP:0000803)	2.56375970
26	Increased corneal curvature (HP:0100692)	2.53195582
27	Keratoconus (HP:0000563)	2.53195582
28	Genital tract atresia (HP:0001827)	2.53139835
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.49942604
30	Nephrogenic diabetes insipidus (HP:0009806)	2.48966411
31	Gastrointestinal atresia (HP:0002589)	2.47626730
32	Vaginal atresia (HP:0000148)	2.46625620
33	Abnormal drinking behavior (HP:0030082)	2.45791476
34	Polydipsia (HP:0001959)	2.45791476
35	Increased CSF lactate (HP:0002490)	2.44220183
36	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.36788231
37	Mitochondrial inheritance (HP:0001427)	2.35414492
38	Abnormal respiratory motile cilium morphology (HP:0005938)	2.34713832
39	Abnormal respiratory epithelium morphology (HP:0012253)	2.34713832
40	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.32423347
41	Postaxial foot polydactyly (HP:0001830)	2.29795452
42	Furrowed tongue (HP:0000221)	2.29279613
43	Asplenia (HP:0001746)	2.29075441
44	Abnormal biliary tract physiology (HP:0012439)	2.26125176
45	Bile duct proliferation (HP:0001408)	2.26125176
46	Hepatocellular necrosis (HP:0001404)	2.25905569
47	Inability to walk (HP:0002540)	2.25885026
48	Decreased central vision (HP:0007663)	2.24473091
49	Acute necrotizing encephalopathy (HP:0006965)	2.23478042
50	Congenital hepatic fibrosis (HP:0002612)	2.20654464
51	Oligodactyly (hands) (HP:0001180)	2.18704394
52	Large for gestational age (HP:0001520)	2.15959499
53	Optic nerve hypoplasia (HP:0000609)	2.15036002
54	Male pseudohermaphroditism (HP:0000037)	2.11431337
55	Poor coordination (HP:0002370)	2.11290983
56	Postaxial hand polydactyly (HP:0001162)	2.10259286
57	Hepatic necrosis (HP:0002605)	2.10224693
58	Polyuria (HP:0000103)	2.03161007
59	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.02578075
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.00840923
61	Progressive macrocephaly (HP:0004481)	1.99578066
62	Absent speech (HP:0001344)	1.99519553
63	Acute encephalopathy (HP:0006846)	1.96904908
64	Absent/shortened dynein arms (HP:0200106)	1.96643195
65	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.96643195
66	Abnormal ciliary motility (HP:0012262)	1.93247350
67	Hyperglycinuria (HP:0003108)	1.92819328
68	Atonic seizures (HP:0010819)	1.90409113
69	Narrow forehead (HP:0000341)	1.89454987
70	Gaze-evoked nystagmus (HP:0000640)	1.89452398
71	Septo-optic dysplasia (HP:0100842)	1.88924120
72	Lissencephaly (HP:0001339)	1.88536156
73	Broad-based gait (HP:0002136)	1.88253160
74	Hypothermia (HP:0002045)	1.87179729
75	Optic disc pallor (HP:0000543)	1.85186876
76	Abnormal respiratory motile cilium physiology (HP:0012261)	1.84614722
77	Occipital encephalocele (HP:0002085)	1.84064860
78	Colon cancer (HP:0003003)	1.83676720
79	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.83472971
80	Retinal dysplasia (HP:0007973)	1.83414863
81	Focal motor seizures (HP:0011153)	1.82641398
82	Oculomotor apraxia (HP:0000657)	1.82044404
83	Preaxial hand polydactyly (HP:0001177)	1.81311499
84	Congenital, generalized hypertrichosis (HP:0004540)	1.81136666
85	Aganglionic megacolon (HP:0002251)	1.81060722
86	Abnormality of alanine metabolism (HP:0010916)	1.80499064
87	Hyperalaninemia (HP:0003348)	1.80499064
88	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.80499064
89	Severe visual impairment (HP:0001141)	1.80170315
90	Rib fusion (HP:0000902)	1.80098333
91	Pachygyria (HP:0001302)	1.79839720
92	Anophthalmia (HP:0000528)	1.79831009
93	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.78885897
94	Methylmalonic acidemia (HP:0002912)	1.78645302
95	Focal seizures (HP:0007359)	1.78132226
96	Calf muscle hypertrophy (HP:0008981)	1.77524503
97	Bony spicule pigmentary retinopathy (HP:0007737)	1.77160197
98	Limb dystonia (HP:0002451)	1.76795166
99	Increased serum lactate (HP:0002151)	1.75757080
100	Abnormal mitochondria in muscle tissue (HP:0008316)	1.75629011

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.74064785
2	MAP4K2	4.20283697
3	TLK1	3.65257828
4	TAOK2	3.33372750
5	CASK	3.21046438
6	WNK3	2.83888278
7	ADRBK2	2.77757247
8	MAP2K6	2.56809290
9	INSRR	2.32113880
10	GRK1	2.26503137
11	WNK4	2.23751108
12	PINK1	2.00737443
13	BMPR1B	1.96962170
14	MUSK	1.95857878
15	MAP3K4	1.70744676
16	MAPK13	1.68083307
17	STK39	1.61974736
18	NUAK1	1.60353010
19	TRIM28	1.59313863
20	ACVR1B	1.55533333
21	TAOK3	1.51749037
22	OXSR1	1.50923520
23	ZAK	1.50717484
24	TNIK	1.40164569
25	NME1	1.36964468
26	MARK1	1.28271594
27	MAPK15	1.25463088
28	MAP3K5	1.20444409
29	BCR	1.18047701
30	MAPKAPK5	1.17713642
31	SIK2	1.10148509
32	EPHA4	1.09174972
33	PAK3	1.08712653
34	BCKDK	1.07897244
35	MAP2K7	1.06566666
36	TXK	0.99545472
37	NTRK2	0.98039049
38	FGFR2	0.97125548
39	MAPKAPK3	0.91891766
40	DYRK2	0.91859230
41	PLK2	0.90369316
42	PRKCG	0.88625936
43	PIK3CA	0.87865453
44	CDK19	0.85954686
45	MKNK2	0.83571251
46	VRK1	0.82908721
47	ADRBK1	0.80526777
48	EIF2AK3	0.79940192
49	CSNK1G2	0.77030514
50	PRKCE	0.75955801
51	CSNK1G1	0.69682674
52	PNCK	0.69667009
53	CCNB1	0.67678579
54	EPHB2	0.67272903
55	CSNK1G3	0.65713949
56	TGFBR1	0.63691826
57	PTK2B	0.63310331
58	NTRK3	0.62721688
59	MST4	0.59775954
60	VRK2	0.59392505
61	DAPK2	0.57479962
62	STK16	0.56727273
63	PHKG1	0.56455320
64	PHKG2	0.56455320
65	BRSK2	0.56303405
66	STK38L	0.55062250
67	CAMKK2	0.53419282
68	IRAK1	0.52027669
69	NLK	0.51166232
70	PLK3	0.49108619
71	PKN1	0.48766285
72	CAMK2A	0.47477266
73	EPHA3	0.46579568
74	CSNK1A1L	0.46150863
75	PRKACA	0.42887856
76	PRKCQ	0.41881428
77	CDK8	0.41392503
78	CSNK1A1	0.40322334
79	PLK4	0.38279370
80	TEC	0.36178765
81	PRKCZ	0.35856730
82	CAMK1	0.35730647
83	CSNK1D	0.35223937
84	ERBB3	0.35001876
85	PRKCI	0.33392005
86	MAP3K12	0.32996731
87	STK3	0.32789876
88	TIE1	0.32134239
89	ITK	0.32011278
90	CHEK2	0.31359845
91	MAPK7	0.31226453
92	WEE1	0.31073069
93	STK11	0.30535336
94	MKNK1	0.30237734
95	MARK3	0.28775361
96	CDK3	0.28398679
97	PRKACB	0.28356507
98	TSSK6	0.25822519
99	OBSCN	0.25762605
100	PRKCA	0.24898072

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	2.74168742
2	Phototransduction_Homo sapiens_hsa04744	2.62930412
3	Butanoate metabolism_Homo sapiens_hsa00650	2.44094739
4	Protein export_Homo sapiens_hsa03060	2.43891965
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.32806934
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.23836149
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.23020331
8	Nicotine addiction_Homo sapiens_hsa05033	2.18236742
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.16991135
10	Parkinsons disease_Homo sapiens_hsa05012	2.15005605
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.14893960
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.05869260
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.00784452
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.95630937
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.91580055
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.76975432
17	Basal transcription factors_Homo sapiens_hsa03022	1.74589562
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.73535605
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.72265051
20	RNA polymerase_Homo sapiens_hsa03020	1.68132108
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.67886714
22	Caffeine metabolism_Homo sapiens_hsa00232	1.66962496
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.66581464
24	Propanoate metabolism_Homo sapiens_hsa00640	1.63925528
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.62795385
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.62082115
27	Homologous recombination_Homo sapiens_hsa03440	1.61562706
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.60824565
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.49141949
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45739329
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.44649000
32	Alzheimers disease_Homo sapiens_hsa05010	1.41620695
33	Huntingtons disease_Homo sapiens_hsa05016	1.41097075
34	Taste transduction_Homo sapiens_hsa04742	1.37915416
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.36978289
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.33262883
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.31117306
38	RNA degradation_Homo sapiens_hsa03018	1.26249938
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.25870704
40	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25636173
41	Olfactory transduction_Homo sapiens_hsa04740	1.20240593
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.17610633
43	Peroxisome_Homo sapiens_hsa04146	1.16953732
44	Morphine addiction_Homo sapiens_hsa05032	1.14904996
45	Retinol metabolism_Homo sapiens_hsa00830	1.05956240
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.05735929
47	One carbon pool by folate_Homo sapiens_hsa00670	1.04461001
48	Histidine metabolism_Homo sapiens_hsa00340	1.00691793
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98518307
50	Regulation of autophagy_Homo sapiens_hsa04140	0.96649568
51	GABAergic synapse_Homo sapiens_hsa04727	0.95669288
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.91714365
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90685768
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.86791486
55	Insulin secretion_Homo sapiens_hsa04911	0.86409292
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.85926256
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.85783567
58	ABC transporters_Homo sapiens_hsa02010	0.85589133
59	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.84190845
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81701729
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.79739819
62	Ribosome_Homo sapiens_hsa03010	0.78265287
63	Serotonergic synapse_Homo sapiens_hsa04726	0.77286073
64	Glutamatergic synapse_Homo sapiens_hsa04724	0.77009259
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.76838558
66	Circadian entrainment_Homo sapiens_hsa04713	0.73783157
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72229649
68	Mineral absorption_Homo sapiens_hsa04978	0.70586237
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68834934
70	Metabolic pathways_Homo sapiens_hsa01100	0.68593498
71	Sulfur relay system_Homo sapiens_hsa04122	0.68141108
72	Cocaine addiction_Homo sapiens_hsa05030	0.66592858
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.65794818
74	Purine metabolism_Homo sapiens_hsa00230	0.65017008
75	Salivary secretion_Homo sapiens_hsa04970	0.64644905
76	Steroid biosynthesis_Homo sapiens_hsa00100	0.62879227
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.61259867
78	Fatty acid elongation_Homo sapiens_hsa00062	0.59506145
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57974565
80	Fatty acid degradation_Homo sapiens_hsa00071	0.57408867
81	Proteasome_Homo sapiens_hsa03050	0.55065189
82	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.54455467
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51849386
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.51494010
85	Sulfur metabolism_Homo sapiens_hsa00920	0.50819518
86	Circadian rhythm_Homo sapiens_hsa04710	0.50388072
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45988913
88	Primary immunodeficiency_Homo sapiens_hsa05340	0.44788993
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41763216
90	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.40448095
91	Fatty acid metabolism_Homo sapiens_hsa01212	0.39248764
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.37445993
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.36672191
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.36091520
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32858374
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.32110559
97	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.28540996
98	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.28176502
99	Amphetamine addiction_Homo sapiens_hsa05031	0.28019670
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.26451106

LRRC37A5P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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