ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm capacitation (GO:0048240)	8.69472507
2	chromosome condensation (GO:0030261)	8.63213325
3	response to pheromone (GO:0019236)	8.62454070
4	microtubule depolymerization (GO:0007019)	8.61027289
5	plasma membrane fusion (GO:0045026)	8.41552141
6	DNA packaging (GO:0006323)	8.32829296
7	protein targeting to Golgi (GO:0000042)	8.00906624
8	establishment of protein localization to Golgi (GO:0072600)	7.68705813
9	spermatid nucleus differentiation (GO:0007289)	7.54501530
10	retrograde transport, vesicle recycling within Golgi (GO:0000301)	7.48901269
11	spermatid development (GO:0007286)	7.46646477
12	multicellular organism reproduction (GO:0032504)	7.40002968
13	sperm-egg recognition (GO:0035036)	7.36683753
14	single strand break repair (GO:0000012)	7.30808356
15	microtubule polymerization or depolymerization (GO:0031109)	7.26232970
16	rRNA methylation (GO:0031167)	6.93709863
17	protein polyglutamylation (GO:0018095)	6.80265554
18	reproduction (GO:0000003)	6.73033060
19	binding of sperm to zona pellucida (GO:0007339)	6.52956260
20	calcium ion-dependent exocytosis (GO:0017156)	6.51650549
21	centriole replication (GO:0007099)	6.33983308
22	axonemal dynein complex assembly (GO:0070286)	6.23285471
23	spermatogenesis (GO:0007283)	6.16827061
24	male gamete generation (GO:0048232)	6.14682100
25	cell-cell recognition (GO:0009988)	6.07055833
26	sexual reproduction (GO:0019953)	5.80625377
27	protein localization to Golgi apparatus (GO:0034067)	5.79808874
28	rRNA modification (GO:0000154)	5.72030985
29	gamete generation (GO:0007276)	5.65054265
30	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.63997028
31	negative regulation of inclusion body assembly (GO:0090084)	5.59808256
32	microtubule severing (GO:0051013)	5.52083080
33	centriole assembly (GO:0098534)	5.48650527
34	seminiferous tubule development (GO:0072520)	5.36560189
35	phosphatidylethanolamine metabolic process (GO:0046337)	5.32511220
36	regulation of centriole replication (GO:0046599)	5.25548057
37	single fertilization (GO:0007338)	5.25497039
38	motile cilium assembly (GO:0044458)	5.22813940
39	cilium or flagellum-dependent cell motility (GO:0001539)	5.07479760
40	positive regulation of Rab GTPase activity (GO:0032851)	4.96278567
41	regulation of Rab GTPase activity (GO:0032313)	4.96278567
42	cellular ketone body metabolic process (GO:0046950)	4.93703319
43	regulation of cilium movement (GO:0003352)	4.91525824
44	epithelial cilium movement (GO:0003351)	4.56790370
45	RNA destabilization (GO:0050779)	4.50827385
46	ketone body metabolic process (GO:1902224)	4.49776493
47	multicellular organismal reproductive process (GO:0048609)	4.48043019
48	fertilization (GO:0009566)	4.43401884
49	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.36512559
50	germ cell development (GO:0007281)	4.31662935
51	cell wall macromolecule catabolic process (GO:0016998)	4.25938666
52	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.16449068
53	chromatin silencing (GO:0006342)	4.16229664
54	cell wall macromolecule metabolic process (GO:0044036)	4.10988399
55	glomerular visceral epithelial cell development (GO:0072015)	4.09176707
56	cilium movement (GO:0003341)	4.06908899
57	coenzyme catabolic process (GO:0009109)	3.96357783
58	regulation of transcription involved in cell fate commitment (GO:0060850)	3.94373582
59	nucleus organization (GO:0006997)	3.91309159
60	regulation of inclusion body assembly (GO:0090083)	3.86449977
61	glomerular epithelial cell development (GO:0072310)	3.85352707
62	glycerol ether metabolic process (GO:0006662)	3.78640150
63	microtubule nucleation (GO:0007020)	3.70303862
64	multicellular organismal movement (GO:0050879)	3.52410915
65	musculoskeletal movement (GO:0050881)	3.52410915
66	polyamine biosynthetic process (GO:0006596)	3.51815093
67	ether metabolic process (GO:0018904)	3.49423842
68	organic cation transport (GO:0015695)	3.46189755
69	intra-Golgi vesicle-mediated transport (GO:0006891)	3.31226212
70	negative regulation of Rho protein signal transduction (GO:0035024)	3.25510980
71	protein depolymerization (GO:0051261)	3.23763396
72	regulation of interleukin-13 production (GO:0032656)	3.15149354
73	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.13685848
74	cell recognition (GO:0008037)	3.07131886
75	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.07123514
76	regulation of microtubule-based movement (GO:0060632)	2.98972383
77	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.98586583
78	male meiosis (GO:0007140)	2.95691225
79	axoneme assembly (GO:0035082)	2.95632430
80	histone H3-K9 demethylation (GO:0033169)	2.92456129
81	membrane protein intracellular domain proteolysis (GO:0031293)	2.90352054
82	cellular response to pH (GO:0071467)	2.85306507
83	peptidyl-threonine dephosphorylation (GO:0035970)	2.83764524
84	response to acidic pH (GO:0010447)	2.81932021
85	cerebral cortex neuron differentiation (GO:0021895)	2.81165720
86	multicellular organismal development (GO:0007275)	2.79993854
87	negative regulation of gene expression, epigenetic (GO:0045814)	2.79656665
88	homeostasis of number of cells within a tissue (GO:0048873)	2.78289134
89	ventricular system development (GO:0021591)	2.77524939
90	positive regulation of guanylate cyclase activity (GO:0031284)	2.71258793
91	Golgi to endosome transport (GO:0006895)	2.71098257
92	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.70297363
93	nucleosome disassembly (GO:0006337)	2.65634674
94	protein-DNA complex disassembly (GO:0032986)	2.65634674
95	regulation of T-helper 2 cell differentiation (GO:0045628)	2.62283571
96	piRNA metabolic process (GO:0034587)	2.61562919
97	receptor recycling (GO:0001881)	2.61022924
98	sperm motility (GO:0030317)	11.7043013
99	acrosome reaction (GO:0007340)	11.4425516
100	fusion of sperm to egg plasma membrane (GO:0007342)	11.0795514

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.26696281
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.78630062
3	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.61401457
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.61401457
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.58189163
6	FUS_26573619_Chip-Seq_HEK293_Human	2.52610564
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.49237344
8	CBP_20019798_ChIP-Seq_JUKART_Human	2.47985822
9	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.47985822
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.47848495
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.41797974
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.19393020
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.16963372
14	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	2.04219658
15	TAF15_26573619_Chip-Seq_HEK293_Human	1.82164129
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78329491
17	ZNF274_21170338_ChIP-Seq_K562_Hela	1.76540350
18	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.75714361
19	RAC3_21632823_ChIP-Seq_H3396_Human	1.74775946
20	ERA_21632823_ChIP-Seq_H3396_Human	1.74714788
21	P300_19829295_ChIP-Seq_ESCs_Human	1.73642006
22	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.71424359
23	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.70395468
24	AR_25329375_ChIP-Seq_VCAP_Human	1.69327293
25	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.69024474
26	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.66567198
27	NANOG_20526341_ChIP-Seq_ESCs_Human	1.61619202
28	MYC_19829295_ChIP-Seq_ESCs_Human	1.59280576
29	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.57858100
30	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.55173263
31	EZH2_22144423_ChIP-Seq_EOC_Human	1.54503971
32	DROSHA_22980978_ChIP-Seq_HELA_Human	1.54079680
33	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.52931007
34	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.52108255
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.48996348
36	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.48735234
37	TP53_18474530_ChIP-ChIP_U2OS_Human	1.48727839
38	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.48714705
39	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.46669223
40	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.46441578
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.46412274
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45352047
43	VDR_22108803_ChIP-Seq_LS180_Human	1.43462324
44	RBPJ_21746931_ChIP-Seq_IB4_Human	1.43090341
45	TAF2_19829295_ChIP-Seq_ESCs_Human	1.41681909
46	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.40645009
47	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40273625
48	NFYB_21822215_ChIP-Seq_K562_Human	1.40198066
49	ETV1_20927104_ChIP-Seq_GIST48_Human	1.40105128
50	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39822754
51	TBL1_22424771_ChIP-Seq_293T_Human	1.38761201
52	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38295574
53	STAT3_23295773_ChIP-Seq_U87_Human	1.35688491
54	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.35119166
55	OCT4_20526341_ChIP-Seq_ESCs_Human	1.34047745
56	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.33768659
57	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.32726253
58	RUNX2_22187159_ChIP-Seq_PCA_Human	1.30970556
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30255281
60	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.29506400
61	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.28208576
62	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.27901595
63	PHF8_20622853_ChIP-Seq_HELA_Human	1.27047380
64	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25410322
65	ERG_20517297_ChIP-Seq_VCAP_Human	1.24940282
66	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22600552
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21344261
68	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21344261
69	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.18831334
70	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.18034764
71	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.17658086
72	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.17155203
73	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17030991
74	CEBPB_22108803_ChIP-Seq_LS180_Human	1.16811455
75	NFYA_21822215_ChIP-Seq_K562_Human	1.16726792
76	CTCF_27219007_Chip-Seq_Bcells_Human	1.16148617
77	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.15018300
78	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14448784
79	CTCF_20526341_ChIP-Seq_ESCs_Human	1.12626178
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12498092
81	BCL6_27268052_Chip-Seq_Bcells_Human	1.12382044
82	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.12000489
83	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.11514105
84	SMRT_27268052_Chip-Seq_Bcells_Human	1.10969154
85	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.09591138
86	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.09046949
87	KDM2B_26808549_Chip-Seq_REH_Human	1.08840419
88	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.08180386
89	E2F1_20622854_ChIP-Seq_HELA_Human	1.07958888
90	TP63_22573176_ChIP-Seq_HFKS_Human	1.07297466
91	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.07195242
92	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.05201948
93	SMC4_20622854_ChIP-Seq_HELA_Human	1.04689373
94	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.04003062
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03810923
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03810923
97	RUNX_20019798_ChIP-Seq_JUKART_Human	1.02634035
98	BCOR_27268052_Chip-Seq_Bcells_Human	1.02363382
99	CJUN_26792858_Chip-Seq_BT549_Human	1.02004537
100	PHF8_20622854_ChIP-Seq_HELA_Human	1.01742203

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	5.27949309
2	MP0003878_abnormal_ear_physiology	5.27949309
3	MP0003698_abnormal_male_reproductive	4.22998910
4	MP0005670_abnormal_white_adipose	3.73255871
5	MP0001929_abnormal_gametogenesis	3.71425350
6	MP0001348_abnormal_lacrimal_gland	2.75192810
7	MP0003718_maternal_effect	2.34592540
8	MP0002161_abnormal_fertility/fecundity	2.25505009
9	MP0000678_abnormal_parathyroid_gland	2.05452892
10	MP0005410_abnormal_fertilization	11.5982217
11	MP0003646_muscle_fatigue	1.97299821
12	MP0003011_delayed_dark_adaptation	1.95432402
13	MP0001485_abnormal_pinna_reflex	1.84093584
14	MP0005379_endocrine/exocrine_gland_phen	1.81170231
15	MP0001486_abnormal_startle_reflex	1.75696384
16	MP0002132_abnormal_respiratory_system	1.73410015
17	MP0004510_myositis	1.66141252
18	MP0002234_abnormal_pharynx_morphology	1.64215337
19	MP0005248_abnormal_Harderian_gland	1.63637060
20	MP0005423_abnormal_somatic_nervous	1.61585372
21	MP0002210_abnormal_sex_determination	1.61111070
22	MP0001968_abnormal_touch/_nociception	1.55201404
23	MP0003879_abnormal_hair_cell	1.52726749
24	MP0005253_abnormal_eye_physiology	1.43671337
25	MP0005310_abnormal_salivary_gland	1.40070772
26	MP0004742_abnormal_vestibular_system	1.35925111
27	MP0002735_abnormal_chemical_nociception	1.32366382
28	MP0001145_abnormal_male_reproductive	1.30729415
29	MP0001765_abnormal_ion_homeostasis	1.29138973
30	MP0000653_abnormal_sex_gland	1.27702851
31	MP0008877_abnormal_DNA_methylation	1.27058430
32	MP0005083_abnormal_biliary_tract	1.25462306
33	MP0002282_abnormal_trachea_morphology	1.25375855
34	MP0001963_abnormal_hearing_physiology	1.21074761
35	MP0005551_abnormal_eye_electrophysiolog	1.20907753
36	MP0001984_abnormal_olfaction	1.20436130
37	MP0009697_abnormal_copulation	1.08968880
38	MP0005395_other_phenotype	1.08381689
39	MP0004084_abnormal_cardiac_muscle	1.06392764
40	MP0002822_catalepsy	1.06020449
41	MP0000026_abnormal_inner_ear	1.04778953
42	MP0005167_abnormal_blood-brain_barrier	1.04771537
43	MP0004859_abnormal_synaptic_plasticity	1.00513501
44	MP0002138_abnormal_hepatobiliary_system	1.00167711
45	MP0002229_neurodegeneration	0.98602445
46	MP0004036_abnormal_muscle_relaxation	0.95964000
47	MP0009053_abnormal_anal_canal	0.93841318
48	MP0004085_abnormal_heartbeat	0.93355459
49	MP0002249_abnormal_larynx_morphology	0.88919146
50	MP0005451_abnormal_body_composition	0.88516393
51	MP0002736_abnormal_nociception_after	0.88283379
52	MP0002127_abnormal_cardiovascular_syste	0.88264892
53	MP0002102_abnormal_ear_morphology	0.88126722
54	MP0009115_abnormal_fat_cell	0.87356888
55	MP0002067_abnormal_sensory_capabilities	0.86437675
56	MP0005367_renal/urinary_system_phenotyp	0.82735501
57	MP0000516_abnormal_urinary_system	0.82735501
58	MP0000534_abnormal_ureter_morphology	0.76570127
59	MP0000230_abnormal_systemic_arterial	0.76373041
60	MP0002653_abnormal_ependyma_morphology	0.76151444
61	MP0002733_abnormal_thermal_nociception	0.73932348
62	MP0002557_abnormal_social/conspecific_i	0.72981852
63	MP0002572_abnormal_emotion/affect_behav	0.70150926
64	MP0000955_abnormal_spinal_cord	0.69332731
65	MP0004484_altered_response_of	0.67672494
66	MP0003137_abnormal_impulse_conducting	0.67478997
67	MP0008775_abnormal_heart_ventricle	0.65296058
68	MP0001905_abnormal_dopamine_level	0.65204482
69	MP0005636_abnormal_mineral_homeostasis	0.62559240
70	MP0002272_abnormal_nervous_system	0.60885600
71	MP0003172_abnormal_lysosome_physiology	0.60204118
72	MP0003880_abnormal_central_pattern	0.59422866
73	MP0005408_hypopigmentation	0.59156428
74	MP0006276_abnormal_autonomic_nervous	0.58262999
75	MP0005391_vision/eye_phenotype	0.57467918
76	MP0005084_abnormal_gallbladder_morpholo	0.55936132
77	MP0005535_abnormal_body_temperature	0.54757427
78	MP0001970_abnormal_pain_threshold	0.54031714
79	MP0008995_early_reproductive_senescence	0.53922359
80	MP0000049_abnormal_middle_ear	0.53898439
81	MP0008961_abnormal_basal_metabolism	0.53655303
82	MP0000681_abnormal_thyroid_gland	0.53447663
83	MP0008789_abnormal_olfactory_epithelium	0.52568178
84	MP0005499_abnormal_olfactory_system	0.52189741
85	MP0005394_taste/olfaction_phenotype	0.52189741
86	MP0001879_abnormal_lymphatic_vessel	0.50705707
87	MP0002638_abnormal_pupillary_reflex	0.50607188
88	MP0009745_abnormal_behavioral_response	0.49631687
89	MP0008569_lethality_at_weaning	0.49302286
90	MP0009046_muscle_twitch	0.47219887
91	MP0010329_abnormal_lipoprotein_level	0.47082152
92	MP0008004_abnormal_stomach_pH	0.44961286
93	MP0001986_abnormal_taste_sensitivity	0.43827452
94	MP0005666_abnormal_adipose_tissue	0.43535215
95	MP0009780_abnormal_chondrocyte_physiolo	0.42739079
96	MP0000372_irregular_coat_pigmentation	0.42027311
97	MP0001501_abnormal_sleep_pattern	0.41285420
98	MP0006292_abnormal_olfactory_placode	0.41234390
99	MP0003631_nervous_system_phenotype	0.40870720
100	MP0003787_abnormal_imprinting	0.40659705

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.34057791
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.45447040
3	Absent/shortened dynein arms (HP:0200106)	6.45447040
4	Tubulointerstitial nephritis (HP:0001970)	6.21027255
5	Chronic hepatic failure (HP:0100626)	5.40874013
6	Asymmetric septal hypertrophy (HP:0001670)	5.18916054
7	Abnormal ciliary motility (HP:0012262)	5.10013477
8	Abnormal respiratory motile cilium physiology (HP:0012261)	4.77936300
9	Attenuation of retinal blood vessels (HP:0007843)	4.64097697
10	Abnormal respiratory epithelium morphology (HP:0012253)	4.62630164
11	Abnormal respiratory motile cilium morphology (HP:0005938)	4.62630164
12	Resting tremor (HP:0002322)	4.48537928
13	Bony spicule pigmentary retinopathy (HP:0007737)	4.43006404
14	Hyperkalemia (HP:0002153)	4.26969531
15	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.08936370
16	Male infertility (HP:0003251)	4.07878704
17	Abnormality of macular pigmentation (HP:0008002)	4.04921765
18	Nasal polyposis (HP:0100582)	3.98021879
19	Infertility (HP:0000789)	3.84606527
20	Cone-rod dystrophy (HP:0000548)	3.84171953
21	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.64453204
22	Abnormal rod and cone electroretinograms (HP:0008323)	3.61981074
23	Hypoplastic ischia (HP:0003175)	3.58611159
24	Progressive sensorineural hearing impairment (HP:0000408)	3.52504938
25	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.48634300
26	Abnormality of dental color (HP:0011073)	3.23950274
27	Amelogenesis imperfecta (HP:0000705)	3.22016905
28	Bell-shaped thorax (HP:0001591)	3.20098647
29	Hypoplasia of the thymus (HP:0000778)	3.17874422
30	Facial shape deformation (HP:0011334)	3.17717047
31	Potter facies (HP:0002009)	3.17717047
32	Abnormality of the nasal mucosa (HP:0000433)	3.17452204
33	Abnormality of the ischium (HP:0003174)	3.16758582
34	Enlarged epiphyses (HP:0010580)	3.09451609
35	Menstrual irregularities (HP:0000858)	3.02845790
36	Stage 5 chronic kidney disease (HP:0003774)	2.98090789
37	Hypoalphalipoproteinemia (HP:0003233)	2.97468648
38	Abnormal spermatogenesis (HP:0008669)	2.92690315
39	Impulsivity (HP:0100710)	2.91511751
40	Nephronophthisis (HP:0000090)	2.89699887
41	Postural instability (HP:0002172)	2.88110983
42	Generalized aminoaciduria (HP:0002909)	2.87551861
43	Tubulointerstitial abnormality (HP:0001969)	2.82603157
44	Rhinitis (HP:0012384)	2.80304429
45	Truncal obesity (HP:0001956)	2.76609348
46	Progressive cerebellar ataxia (HP:0002073)	2.66205284
47	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.63824404
48	Azoospermia (HP:0000027)	2.63123388
49	Portal hypertension (HP:0001409)	2.62678063
50	Insulin-resistant diabetes mellitus (HP:0000831)	2.61344071
51	Unilateral renal agenesis (HP:0000122)	2.53124295
52	Abnormal urine output (HP:0012590)	2.51453817
53	Abnormal drinking behavior (HP:0030082)	2.50175376
54	Polydipsia (HP:0001959)	2.50175376
55	Intellectual disability, moderate (HP:0002342)	2.48779656
56	Abnormality of the renal medulla (HP:0100957)	2.43754718
57	Abnormality of potassium homeostasis (HP:0011042)	2.41882155
58	Abnormality of the hepatic vasculature (HP:0006707)	2.40279891
59	Progressive hearing impairment (HP:0001730)	2.39362267
60	Focal segmental glomerulosclerosis (HP:0000097)	2.31822662
61	Congenital malformation of the right heart (HP:0011723)	2.29170254
62	Double outlet right ventricle (HP:0001719)	2.29170254
63	Abnormality of the costochondral junction (HP:0000919)	2.29169061
64	Renovascular hypertension (HP:0100817)	2.20613039
65	Abnormality of renal excretion (HP:0011036)	2.17819414
66	Polyuria (HP:0000103)	2.17417978
67	Bronchiectasis (HP:0002110)	2.17141518
68	Renal dysplasia (HP:0000110)	2.15704687
69	Decreased central vision (HP:0007663)	2.13303685
70	Increased purine levels (HP:0004368)	2.06362727
71	Hyperuricemia (HP:0002149)	2.06362727
72	Abnormality of the aortic arch (HP:0012303)	2.06196050
73	Upper limb muscle weakness (HP:0003484)	2.04503818
74	Hypophosphatemic rickets (HP:0004912)	2.00390934
75	Chronic bronchitis (HP:0004469)	2.00318735
76	Hypoalbuminemia (HP:0003073)	1.99190868
77	Abnormal albumin level (HP:0012116)	1.99190868
78	Congenital sensorineural hearing impairment (HP:0008527)	1.97867738
79	Horizontal nystagmus (HP:0000666)	1.97152931
80	Optic nerve hypoplasia (HP:0000609)	1.87023612
81	Glomerulosclerosis (HP:0000096)	1.86945976
82	Photophobia (HP:0000613)	1.86851530
83	Abnormality of the parathyroid morphology (HP:0011766)	1.86793173
84	Flattened epiphyses (HP:0003071)	1.85059216
85	Pancreatic fibrosis (HP:0100732)	1.83056256
86	Widely patent fontanelles and sutures (HP:0004492)	1.82308040
87	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.79917461
88	Absent epiphyses (HP:0010577)	1.79917461
89	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.79871099
90	Insidious onset (HP:0003587)	1.75983656
91	Termporal pattern (HP:0011008)	1.75983656
92	Hyponatremia (HP:0002902)	1.75909513
93	Tubular atrophy (HP:0000092)	1.74816577
94	Abnormality of lateral ventricle (HP:0030047)	1.72457620
95	Bradycardia (HP:0001662)	1.72450415
96	Failure to thrive in infancy (HP:0001531)	1.70323765
97	Ventricular tachycardia (HP:0004756)	1.70321828
98	Pancreatic cysts (HP:0001737)	1.69527800
99	Abnormality of the pubic bones (HP:0003172)	1.66920078
100	Protuberant abdomen (HP:0001538)	1.66659830

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.85425370
2	TESK1	4.99746965
3	INSRR	4.59832779
4	MAP4K2	4.37131523
5	PLK2	4.14166017
6	DDR2	3.70489703
7	BRD4	3.66555272
8	PNCK	2.86003323
9	PRKD3	2.41300553
10	STK38	2.31293674
11	PIK3CG	2.23630834
12	CAMK1G	2.06736131
13	STK38L	2.02903306
14	PTK2B	1.73307429
15	MAPK15	1.48275053
16	MST1R	1.47893151
17	PDK1	1.45925585
18	PDPK1	1.40569762
19	WNK1	1.34408591
20	NEK6	1.27618911
21	DYRK1B	1.08295416
22	PINK1	1.03082612
23	CDK7	0.97553230
24	MAP2K7	0.86952003
25	FRK	0.85818794
26	CDK12	0.76524854
27	SIK2	0.74769134
28	TRIM28	0.72533513
29	PRKG2	0.72265339
30	MAP3K4	0.72167193
31	PRKG1	0.66778890
32	MARK1	0.66061197
33	BMPR1B	0.65529083
34	LATS1	0.63540540
35	TIE1	0.59642817
36	TYRO3	0.59100329
37	UHMK1	0.55790783
38	AKT3	0.54370483
39	PRKAA2	0.53262821
40	MARK3	0.53061104
41	CAMK1D	0.50381645
42	MUSK	0.50307411
43	SGK494	0.49883355
44	SGK223	0.49883355
45	FER	0.49782353
46	ROCK1	0.49623580
47	ADRBK2	0.48420314
48	DYRK3	0.46512376
49	WNK4	0.45689463
50	CDK3	0.45169936
51	CAMK1	0.44802200
52	MAP2K2	0.42135133
53	CAMK4	0.40077704
54	MAP3K9	0.39912600
55	KSR2	0.39531771
56	STK39	0.38234998
57	MAPK13	0.36349225
58	PRKCG	0.34779199
59	MAPK1	0.34022325
60	GSK3B	0.33942188
61	TESK2	0.33348102
62	PRKCZ	0.33201692
63	OXSR1	0.33196579
64	CDK1	0.33060836
65	LATS2	0.30847044
66	RPS6KA1	0.30846005
67	ERBB3	0.30140617
68	PRKCE	0.29991450
69	MYLK	0.29440914
70	RPS6KA2	0.28645982
71	CDK2	0.28474927
72	PRKCB	0.27320994
73	BCR	0.26711739
74	SGK2	0.25534530
75	MAPK8	0.23304037
76	MAP3K8	0.23216841
77	SGK1	0.22880323
78	ZAK	0.22016159
79	CAMK2A	0.21527602
80	TXK	0.21317370
81	CDK19	0.20704757
82	BRAF	0.20546688
83	MAPK14	0.19869415
84	WNK3	0.19778499
85	CHUK	0.19650690
86	MINK1	0.19165744
87	PKN1	0.17882303
88	MAP3K2	0.17592159
89	CSNK1A1	0.17139060
90	MAPK10	0.16722120
91	CSNK1D	0.15987781
92	CHEK1	0.15974509
93	MAP2K1	0.15262634
94	PRKACB	0.14885674
95	OBSCN	0.14796936
96	MET	0.14218273
97	MAP3K1	0.13701962
98	PRKACA	0.11854787
99	BLK	0.11501619
100	MAP3K11	0.10844710

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.03986598
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.62588614
3	Olfactory transduction_Homo sapiens_hsa04740	4.23761108
4	Butanoate metabolism_Homo sapiens_hsa00650	3.00067238
5	Taste transduction_Homo sapiens_hsa04742	2.08619332
6	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.87396340
7	Phototransduction_Homo sapiens_hsa04744	1.66885462
8	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.65779565
9	RNA transport_Homo sapiens_hsa03013	1.60635222
10	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.55486855
11	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.39690811
12	Phenylalanine metabolism_Homo sapiens_hsa00360	1.39331903
13	Type II diabetes mellitus_Homo sapiens_hsa04930	1.34609061
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.34024629
15	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.33878990
16	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.31555867
17	Fatty acid metabolism_Homo sapiens_hsa01212	1.31487620
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.29825595
19	Fatty acid degradation_Homo sapiens_hsa00071	1.24894951
20	Morphine addiction_Homo sapiens_hsa05032	1.18153772
21	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.15460027
22	Salivary secretion_Homo sapiens_hsa04970	1.14732810
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14335300
24	Endocytosis_Homo sapiens_hsa04144	1.12796704
25	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.10666002
26	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.07796184
27	Circadian entrainment_Homo sapiens_hsa04713	1.07553761
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.06300953
29	Allograft rejection_Homo sapiens_hsa05330	1.03687886
30	Arginine and proline metabolism_Homo sapiens_hsa00330	1.02770888
31	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.01136391
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00421698
33	Oocyte meiosis_Homo sapiens_hsa04114	0.99295160
34	Nitrogen metabolism_Homo sapiens_hsa00910	0.94317992
35	Graft-versus-host disease_Homo sapiens_hsa05332	0.93218639
36	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.91861865
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.91593988
38	Calcium signaling pathway_Homo sapiens_hsa04020	0.90307950
39	cAMP signaling pathway_Homo sapiens_hsa04024	0.90003173
40	Nicotine addiction_Homo sapiens_hsa05033	0.87395087
41	Viral myocarditis_Homo sapiens_hsa05416	0.87223301
42	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.87150385
43	Renin secretion_Homo sapiens_hsa04924	0.85214152
44	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.83943765
45	Serotonergic synapse_Homo sapiens_hsa04726	0.83131461
46	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.82507454
47	GABAergic synapse_Homo sapiens_hsa04727	0.82490290
48	ABC transporters_Homo sapiens_hsa02010	0.81716133
49	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.81274865
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.80421937
51	Arginine biosynthesis_Homo sapiens_hsa00220	0.79549981
52	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.76398046
53	Retinol metabolism_Homo sapiens_hsa00830	0.75196385
54	PPAR signaling pathway_Homo sapiens_hsa03320	0.74650208
55	Insulin secretion_Homo sapiens_hsa04911	0.72564123
56	Propanoate metabolism_Homo sapiens_hsa00640	0.72234720
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.71256177
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.71207764
59	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.66922112
60	Tyrosine metabolism_Homo sapiens_hsa00350	0.66106740
61	Fat digestion and absorption_Homo sapiens_hsa04975	0.65720154
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.63772601
63	Basal transcription factors_Homo sapiens_hsa03022	0.62563581
64	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.62071209
65	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.60568278
66	Gastric acid secretion_Homo sapiens_hsa04971	0.59576241
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59303366
68	Fanconi anemia pathway_Homo sapiens_hsa03460	0.57981652
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57552400
70	Circadian rhythm_Homo sapiens_hsa04710	0.54184502
71	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.53529843
72	Influenza A_Homo sapiens_hsa05164	0.52963794
73	Cholinergic synapse_Homo sapiens_hsa04725	0.52429003
74	Estrogen signaling pathway_Homo sapiens_hsa04915	0.49772937
75	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.49424897
76	Protein digestion and absorption_Homo sapiens_hsa04974	0.49057737
77	Pancreatic secretion_Homo sapiens_hsa04972	0.48761698
78	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.47162988
79	Platelet activation_Homo sapiens_hsa04611	0.45322552
80	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42875171
81	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.42217895
82	Purine metabolism_Homo sapiens_hsa00230	0.40827363
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39571329
84	Amphetamine addiction_Homo sapiens_hsa05031	0.38168380
85	Gap junction_Homo sapiens_hsa04540	0.37440178
86	Legionellosis_Homo sapiens_hsa05134	0.35925119
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35761085
88	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.35589379
89	Tight junction_Homo sapiens_hsa04530	0.33068631
90	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.32631569
91	Bile secretion_Homo sapiens_hsa04976	0.31299443
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30629303
93	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.30592801
94	Long-term potentiation_Homo sapiens_hsa04720	0.30544643
95	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.29265676
96	Cardiac muscle contraction_Homo sapiens_hsa04260	0.28937846
97	Long-term depression_Homo sapiens_hsa04730	0.24227728
98	Herpes simplex infection_Homo sapiens_hsa05168	0.23547811
99	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.23242547
100	ECM-receptor interaction_Homo sapiens_hsa04512	0.21630129

LRRC37A6P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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