LRRC37A6P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)8.69472507
2chromosome condensation (GO:0030261)8.63213325
3response to pheromone (GO:0019236)8.62454070
4microtubule depolymerization (GO:0007019)8.61027289
5plasma membrane fusion (GO:0045026)8.41552141
6DNA packaging (GO:0006323)8.32829296
7protein targeting to Golgi (GO:0000042)8.00906624
8establishment of protein localization to Golgi (GO:0072600)7.68705813
9spermatid nucleus differentiation (GO:0007289)7.54501530
10retrograde transport, vesicle recycling within Golgi (GO:0000301)7.48901269
11spermatid development (GO:0007286)7.46646477
12multicellular organism reproduction (GO:0032504)7.40002968
13sperm-egg recognition (GO:0035036)7.36683753
14single strand break repair (GO:0000012)7.30808356
15microtubule polymerization or depolymerization (GO:0031109)7.26232970
16rRNA methylation (GO:0031167)6.93709863
17protein polyglutamylation (GO:0018095)6.80265554
18reproduction (GO:0000003)6.73033060
19binding of sperm to zona pellucida (GO:0007339)6.52956260
20calcium ion-dependent exocytosis (GO:0017156)6.51650549
21centriole replication (GO:0007099)6.33983308
22axonemal dynein complex assembly (GO:0070286)6.23285471
23spermatogenesis (GO:0007283)6.16827061
24male gamete generation (GO:0048232)6.14682100
25cell-cell recognition (GO:0009988)6.07055833
26sexual reproduction (GO:0019953)5.80625377
27protein localization to Golgi apparatus (GO:0034067)5.79808874
28rRNA modification (GO:0000154)5.72030985
29gamete generation (GO:0007276)5.65054265
30phosphatidylethanolamine biosynthetic process (GO:0006646)5.63997028
31negative regulation of inclusion body assembly (GO:0090084)5.59808256
32microtubule severing (GO:0051013)5.52083080
33centriole assembly (GO:0098534)5.48650527
34seminiferous tubule development (GO:0072520)5.36560189
35phosphatidylethanolamine metabolic process (GO:0046337)5.32511220
36regulation of centriole replication (GO:0046599)5.25548057
37single fertilization (GO:0007338)5.25497039
38motile cilium assembly (GO:0044458)5.22813940
39cilium or flagellum-dependent cell motility (GO:0001539)5.07479760
40positive regulation of Rab GTPase activity (GO:0032851)4.96278567
41regulation of Rab GTPase activity (GO:0032313)4.96278567
42cellular ketone body metabolic process (GO:0046950)4.93703319
43regulation of cilium movement (GO:0003352)4.91525824
44epithelial cilium movement (GO:0003351)4.56790370
45RNA destabilization (GO:0050779)4.50827385
46ketone body metabolic process (GO:1902224)4.49776493
47multicellular organismal reproductive process (GO:0048609)4.48043019
48fertilization (GO:0009566)4.43401884
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.36512559
50germ cell development (GO:0007281)4.31662935
51cell wall macromolecule catabolic process (GO:0016998)4.25938666
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.16449068
53chromatin silencing (GO:0006342)4.16229664
54cell wall macromolecule metabolic process (GO:0044036)4.10988399
55glomerular visceral epithelial cell development (GO:0072015)4.09176707
56cilium movement (GO:0003341)4.06908899
57coenzyme catabolic process (GO:0009109)3.96357783
58regulation of transcription involved in cell fate commitment (GO:0060850)3.94373582
59nucleus organization (GO:0006997)3.91309159
60regulation of inclusion body assembly (GO:0090083)3.86449977
61glomerular epithelial cell development (GO:0072310)3.85352707
62glycerol ether metabolic process (GO:0006662)3.78640150
63microtubule nucleation (GO:0007020)3.70303862
64multicellular organismal movement (GO:0050879)3.52410915
65musculoskeletal movement (GO:0050881)3.52410915
66polyamine biosynthetic process (GO:0006596)3.51815093
67ether metabolic process (GO:0018904)3.49423842
68organic cation transport (GO:0015695)3.46189755
69intra-Golgi vesicle-mediated transport (GO:0006891)3.31226212
70negative regulation of Rho protein signal transduction (GO:0035024)3.25510980
71protein depolymerization (GO:0051261)3.23763396
72regulation of interleukin-13 production (GO:0032656)3.15149354
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13685848
74cell recognition (GO:0008037)3.07131886
75regulation of phosphoprotein phosphatase activity (GO:0043666)3.07123514
76regulation of microtubule-based movement (GO:0060632)2.98972383
77detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.98586583
78male meiosis (GO:0007140)2.95691225
79axoneme assembly (GO:0035082)2.95632430
80histone H3-K9 demethylation (GO:0033169)2.92456129
81membrane protein intracellular domain proteolysis (GO:0031293)2.90352054
82cellular response to pH (GO:0071467)2.85306507
83peptidyl-threonine dephosphorylation (GO:0035970)2.83764524
84response to acidic pH (GO:0010447)2.81932021
85cerebral cortex neuron differentiation (GO:0021895)2.81165720
86multicellular organismal development (GO:0007275)2.79993854
87negative regulation of gene expression, epigenetic (GO:0045814)2.79656665
88homeostasis of number of cells within a tissue (GO:0048873)2.78289134
89ventricular system development (GO:0021591)2.77524939
90positive regulation of guanylate cyclase activity (GO:0031284)2.71258793
91Golgi to endosome transport (GO:0006895)2.71098257
92cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.70297363
93nucleosome disassembly (GO:0006337)2.65634674
94protein-DNA complex disassembly (GO:0032986)2.65634674
95regulation of T-helper 2 cell differentiation (GO:0045628)2.62283571
96piRNA metabolic process (GO:0034587)2.61562919
97receptor recycling (GO:0001881)2.61022924
98sperm motility (GO:0030317)11.7043013
99acrosome reaction (GO:0007340)11.4425516
100fusion of sperm to egg plasma membrane (GO:0007342)11.0795514

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.26696281
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.78630062
3POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.61401457
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61401457
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.58189163
6FUS_26573619_Chip-Seq_HEK293_Human2.52610564
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.49237344
8CBP_20019798_ChIP-Seq_JUKART_Human2.47985822
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.47985822
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.47848495
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.41797974
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19393020
13ER_23166858_ChIP-Seq_MCF-7_Human2.16963372
14UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human2.04219658
15TAF15_26573619_Chip-Seq_HEK293_Human1.82164129
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78329491
17ZNF274_21170338_ChIP-Seq_K562_Hela1.76540350
18ARNT_22903824_ChIP-Seq_MCF-7_Human1.75714361
19RAC3_21632823_ChIP-Seq_H3396_Human1.74775946
20ERA_21632823_ChIP-Seq_H3396_Human1.74714788
21P300_19829295_ChIP-Seq_ESCs_Human1.73642006
22EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.71424359
23SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.70395468
24AR_25329375_ChIP-Seq_VCAP_Human1.69327293
25VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.69024474
26SMAD4_21741376_ChIP-Seq_EPCs_Human1.66567198
27NANOG_20526341_ChIP-Seq_ESCs_Human1.61619202
28MYC_19829295_ChIP-Seq_ESCs_Human1.59280576
29AUTS2_25519132_ChIP-Seq_293T-REX_Human1.57858100
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.55173263
31EZH2_22144423_ChIP-Seq_EOC_Human1.54503971
32DROSHA_22980978_ChIP-Seq_HELA_Human1.54079680
33SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52931007
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.52108255
35GBX2_23144817_ChIP-Seq_PC3_Human1.48996348
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48735234
37TP53_18474530_ChIP-ChIP_U2OS_Human1.48727839
38HNFA_21074721_ChIP-Seq_CACO-2_Human1.48714705
39CBX2_22325352_ChIP-Seq_293T-Rex_Human1.46669223
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.46441578
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46412274
42SMAD4_21799915_ChIP-Seq_A2780_Human1.45352047
43VDR_22108803_ChIP-Seq_LS180_Human1.43462324
44RBPJ_21746931_ChIP-Seq_IB4_Human1.43090341
45TAF2_19829295_ChIP-Seq_ESCs_Human1.41681909
46CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.40645009
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40273625
48NFYB_21822215_ChIP-Seq_K562_Human1.40198066
49ETV1_20927104_ChIP-Seq_GIST48_Human1.40105128
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39822754
51TBL1_22424771_ChIP-Seq_293T_Human1.38761201
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38295574
53STAT3_23295773_ChIP-Seq_U87_Human1.35688491
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.35119166
55OCT4_20526341_ChIP-Seq_ESCs_Human1.34047745
56RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.33768659
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.32726253
58RUNX2_22187159_ChIP-Seq_PCA_Human1.30970556
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.30255281
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29506400
61SMAD3_21741376_ChIP-Seq_ESCs_Human1.28208576
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27901595
63PHF8_20622853_ChIP-Seq_HELA_Human1.27047380
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25410322
65ERG_20517297_ChIP-Seq_VCAP_Human1.24940282
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22600552
67SOX2_19829295_ChIP-Seq_ESCs_Human1.21344261
68NANOG_19829295_ChIP-Seq_ESCs_Human1.21344261
69SMAD4_21741376_ChIP-Seq_HESCs_Human1.18831334
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18034764
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17658086
72GATA6_21074721_ChIP-Seq_CACO-2_Human1.17155203
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17030991
74CEBPB_22108803_ChIP-Seq_LS180_Human1.16811455
75NFYA_21822215_ChIP-Seq_K562_Human1.16726792
76CTCF_27219007_Chip-Seq_Bcells_Human1.16148617
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.15018300
78HOXB7_26014856_ChIP-Seq_BT474_Human1.14448784
79CTCF_20526341_ChIP-Seq_ESCs_Human1.12626178
80FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12498092
81BCL6_27268052_Chip-Seq_Bcells_Human1.12382044
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.12000489
83KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.11514105
84SMRT_27268052_Chip-Seq_Bcells_Human1.10969154
85YY1_22570637_ChIP-Seq_MALME-3M_Human1.09591138
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.09046949
87KDM2B_26808549_Chip-Seq_REH_Human1.08840419
88SALL4_22934838_ChIP-ChIP_CD34+_Human1.08180386
89E2F1_20622854_ChIP-Seq_HELA_Human1.07958888
90TP63_22573176_ChIP-Seq_HFKS_Human1.07297466
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07195242
92OCT1_27270436_Chip-Seq_PROSTATE_Human1.05201948
93SMC4_20622854_ChIP-Seq_HELA_Human1.04689373
94SOX2_22085726_ChIP-Seq_NPCs_Mouse1.04003062
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03810923
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.03810923
97RUNX_20019798_ChIP-Seq_JUKART_Human1.02634035
98BCOR_27268052_Chip-Seq_Bcells_Human1.02363382
99CJUN_26792858_Chip-Seq_BT549_Human1.02004537
100PHF8_20622854_ChIP-Seq_HELA_Human1.01742203

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.27949309
2MP0003878_abnormal_ear_physiology5.27949309
3MP0003698_abnormal_male_reproductive4.22998910
4MP0005670_abnormal_white_adipose3.73255871
5MP0001929_abnormal_gametogenesis3.71425350
6MP0001348_abnormal_lacrimal_gland2.75192810
7MP0003718_maternal_effect2.34592540
8MP0002161_abnormal_fertility/fecundity2.25505009
9MP0000678_abnormal_parathyroid_gland2.05452892
10MP0005410_abnormal_fertilization11.5982217
11MP0003646_muscle_fatigue1.97299821
12MP0003011_delayed_dark_adaptation1.95432402
13MP0001485_abnormal_pinna_reflex1.84093584
14MP0005379_endocrine/exocrine_gland_phen1.81170231
15MP0001486_abnormal_startle_reflex1.75696384
16MP0002132_abnormal_respiratory_system1.73410015
17MP0004510_myositis1.66141252
18MP0002234_abnormal_pharynx_morphology1.64215337
19MP0005248_abnormal_Harderian_gland1.63637060
20MP0005423_abnormal_somatic_nervous1.61585372
21MP0002210_abnormal_sex_determination1.61111070
22MP0001968_abnormal_touch/_nociception1.55201404
23MP0003879_abnormal_hair_cell1.52726749
24MP0005253_abnormal_eye_physiology1.43671337
25MP0005310_abnormal_salivary_gland1.40070772
26MP0004742_abnormal_vestibular_system1.35925111
27MP0002735_abnormal_chemical_nociception1.32366382
28MP0001145_abnormal_male_reproductive1.30729415
29MP0001765_abnormal_ion_homeostasis1.29138973
30MP0000653_abnormal_sex_gland1.27702851
31MP0008877_abnormal_DNA_methylation1.27058430
32MP0005083_abnormal_biliary_tract1.25462306
33MP0002282_abnormal_trachea_morphology1.25375855
34MP0001963_abnormal_hearing_physiology1.21074761
35MP0005551_abnormal_eye_electrophysiolog1.20907753
36MP0001984_abnormal_olfaction1.20436130
37MP0009697_abnormal_copulation1.08968880
38MP0005395_other_phenotype1.08381689
39MP0004084_abnormal_cardiac_muscle1.06392764
40MP0002822_catalepsy1.06020449
41MP0000026_abnormal_inner_ear1.04778953
42MP0005167_abnormal_blood-brain_barrier1.04771537
43MP0004859_abnormal_synaptic_plasticity1.00513501
44MP0002138_abnormal_hepatobiliary_system1.00167711
45MP0002229_neurodegeneration0.98602445
46MP0004036_abnormal_muscle_relaxation0.95964000
47MP0009053_abnormal_anal_canal0.93841318
48MP0004085_abnormal_heartbeat0.93355459
49MP0002249_abnormal_larynx_morphology0.88919146
50MP0005451_abnormal_body_composition0.88516393
51MP0002736_abnormal_nociception_after0.88283379
52MP0002127_abnormal_cardiovascular_syste0.88264892
53MP0002102_abnormal_ear_morphology0.88126722
54MP0009115_abnormal_fat_cell0.87356888
55MP0002067_abnormal_sensory_capabilities0.86437675
56MP0005367_renal/urinary_system_phenotyp0.82735501
57MP0000516_abnormal_urinary_system0.82735501
58MP0000534_abnormal_ureter_morphology0.76570127
59MP0000230_abnormal_systemic_arterial0.76373041
60MP0002653_abnormal_ependyma_morphology0.76151444
61MP0002733_abnormal_thermal_nociception0.73932348
62MP0002557_abnormal_social/conspecific_i0.72981852
63MP0002572_abnormal_emotion/affect_behav0.70150926
64MP0000955_abnormal_spinal_cord0.69332731
65MP0004484_altered_response_of0.67672494
66MP0003137_abnormal_impulse_conducting0.67478997
67MP0008775_abnormal_heart_ventricle0.65296058
68MP0001905_abnormal_dopamine_level0.65204482
69MP0005636_abnormal_mineral_homeostasis0.62559240
70MP0002272_abnormal_nervous_system0.60885600
71MP0003172_abnormal_lysosome_physiology0.60204118
72MP0003880_abnormal_central_pattern0.59422866
73MP0005408_hypopigmentation0.59156428
74MP0006276_abnormal_autonomic_nervous0.58262999
75MP0005391_vision/eye_phenotype0.57467918
76MP0005084_abnormal_gallbladder_morpholo0.55936132
77MP0005535_abnormal_body_temperature0.54757427
78MP0001970_abnormal_pain_threshold0.54031714
79MP0008995_early_reproductive_senescence0.53922359
80MP0000049_abnormal_middle_ear0.53898439
81MP0008961_abnormal_basal_metabolism0.53655303
82MP0000681_abnormal_thyroid_gland0.53447663
83MP0008789_abnormal_olfactory_epithelium0.52568178
84MP0005499_abnormal_olfactory_system0.52189741
85MP0005394_taste/olfaction_phenotype0.52189741
86MP0001879_abnormal_lymphatic_vessel0.50705707
87MP0002638_abnormal_pupillary_reflex0.50607188
88MP0009745_abnormal_behavioral_response0.49631687
89MP0008569_lethality_at_weaning0.49302286
90MP0009046_muscle_twitch0.47219887
91MP0010329_abnormal_lipoprotein_level0.47082152
92MP0008004_abnormal_stomach_pH0.44961286
93MP0001986_abnormal_taste_sensitivity0.43827452
94MP0005666_abnormal_adipose_tissue0.43535215
95MP0009780_abnormal_chondrocyte_physiolo0.42739079
96MP0000372_irregular_coat_pigmentation0.42027311
97MP0001501_abnormal_sleep_pattern0.41285420
98MP0006292_abnormal_olfactory_placode0.41234390
99MP0003631_nervous_system_phenotype0.40870720
100MP0003787_abnormal_imprinting0.40659705

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.34057791
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.45447040
3Absent/shortened dynein arms (HP:0200106)6.45447040
4Tubulointerstitial nephritis (HP:0001970)6.21027255
5Chronic hepatic failure (HP:0100626)5.40874013
6Asymmetric septal hypertrophy (HP:0001670)5.18916054
7Abnormal ciliary motility (HP:0012262)5.10013477
8Abnormal respiratory motile cilium physiology (HP:0012261)4.77936300
9Attenuation of retinal blood vessels (HP:0007843)4.64097697
10Abnormal respiratory epithelium morphology (HP:0012253)4.62630164
11Abnormal respiratory motile cilium morphology (HP:0005938)4.62630164
12Resting tremor (HP:0002322)4.48537928
13Bony spicule pigmentary retinopathy (HP:0007737)4.43006404
14Hyperkalemia (HP:0002153)4.26969531
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.08936370
16Male infertility (HP:0003251)4.07878704
17Abnormality of macular pigmentation (HP:0008002)4.04921765
18Nasal polyposis (HP:0100582)3.98021879
19Infertility (HP:0000789)3.84606527
20Cone-rod dystrophy (HP:0000548)3.84171953
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.64453204
22Abnormal rod and cone electroretinograms (HP:0008323)3.61981074
23Hypoplastic ischia (HP:0003175)3.58611159
24Progressive sensorineural hearing impairment (HP:0000408)3.52504938
25Aplasia/Hypoplasia of the earlobes (HP:0009906)3.48634300
26Abnormality of dental color (HP:0011073)3.23950274
27Amelogenesis imperfecta (HP:0000705)3.22016905
28Bell-shaped thorax (HP:0001591)3.20098647
29Hypoplasia of the thymus (HP:0000778)3.17874422
30Facial shape deformation (HP:0011334)3.17717047
31Potter facies (HP:0002009)3.17717047
32Abnormality of the nasal mucosa (HP:0000433)3.17452204
33Abnormality of the ischium (HP:0003174)3.16758582
34Enlarged epiphyses (HP:0010580)3.09451609
35Menstrual irregularities (HP:0000858)3.02845790
36Stage 5 chronic kidney disease (HP:0003774)2.98090789
37Hypoalphalipoproteinemia (HP:0003233)2.97468648
38Abnormal spermatogenesis (HP:0008669)2.92690315
39Impulsivity (HP:0100710)2.91511751
40Nephronophthisis (HP:0000090)2.89699887
41Postural instability (HP:0002172)2.88110983
42Generalized aminoaciduria (HP:0002909)2.87551861
43Tubulointerstitial abnormality (HP:0001969)2.82603157
44Rhinitis (HP:0012384)2.80304429
45Truncal obesity (HP:0001956)2.76609348
46Progressive cerebellar ataxia (HP:0002073)2.66205284
47Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.63824404
48Azoospermia (HP:0000027)2.63123388
49Portal hypertension (HP:0001409)2.62678063
50Insulin-resistant diabetes mellitus (HP:0000831)2.61344071
51Unilateral renal agenesis (HP:0000122)2.53124295
52Abnormal urine output (HP:0012590)2.51453817
53Abnormal drinking behavior (HP:0030082)2.50175376
54Polydipsia (HP:0001959)2.50175376
55Intellectual disability, moderate (HP:0002342)2.48779656
56Abnormality of the renal medulla (HP:0100957)2.43754718
57Abnormality of potassium homeostasis (HP:0011042)2.41882155
58Abnormality of the hepatic vasculature (HP:0006707)2.40279891
59Progressive hearing impairment (HP:0001730)2.39362267
60Focal segmental glomerulosclerosis (HP:0000097)2.31822662
61Congenital malformation of the right heart (HP:0011723)2.29170254
62Double outlet right ventricle (HP:0001719)2.29170254
63Abnormality of the costochondral junction (HP:0000919)2.29169061
64Renovascular hypertension (HP:0100817)2.20613039
65Abnormality of renal excretion (HP:0011036)2.17819414
66Polyuria (HP:0000103)2.17417978
67Bronchiectasis (HP:0002110)2.17141518
68Renal dysplasia (HP:0000110)2.15704687
69Decreased central vision (HP:0007663)2.13303685
70Increased purine levels (HP:0004368)2.06362727
71Hyperuricemia (HP:0002149)2.06362727
72Abnormality of the aortic arch (HP:0012303)2.06196050
73Upper limb muscle weakness (HP:0003484)2.04503818
74Hypophosphatemic rickets (HP:0004912)2.00390934
75Chronic bronchitis (HP:0004469)2.00318735
76Hypoalbuminemia (HP:0003073)1.99190868
77Abnormal albumin level (HP:0012116)1.99190868
78Congenital sensorineural hearing impairment (HP:0008527)1.97867738
79Horizontal nystagmus (HP:0000666)1.97152931
80Optic nerve hypoplasia (HP:0000609)1.87023612
81Glomerulosclerosis (HP:0000096)1.86945976
82Photophobia (HP:0000613)1.86851530
83Abnormality of the parathyroid morphology (HP:0011766)1.86793173
84Flattened epiphyses (HP:0003071)1.85059216
85Pancreatic fibrosis (HP:0100732)1.83056256
86Widely patent fontanelles and sutures (HP:0004492)1.82308040
87Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79917461
88Absent epiphyses (HP:0010577)1.79917461
89Abnormality of the epiphysis of the femoral head (HP:0010574)1.79871099
90Insidious onset (HP:0003587)1.75983656
91Termporal pattern (HP:0011008)1.75983656
92Hyponatremia (HP:0002902)1.75909513
93Tubular atrophy (HP:0000092)1.74816577
94Abnormality of lateral ventricle (HP:0030047)1.72457620
95Bradycardia (HP:0001662)1.72450415
96Failure to thrive in infancy (HP:0001531)1.70323765
97Ventricular tachycardia (HP:0004756)1.70321828
98Pancreatic cysts (HP:0001737)1.69527800
99Abnormality of the pubic bones (HP:0003172)1.66920078
100Protuberant abdomen (HP:0001538)1.66659830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.85425370
2TESK14.99746965
3INSRR4.59832779
4MAP4K24.37131523
5PLK24.14166017
6DDR23.70489703
7BRD43.66555272
8PNCK2.86003323
9PRKD32.41300553
10STK382.31293674
11PIK3CG2.23630834
12CAMK1G2.06736131
13STK38L2.02903306
14PTK2B1.73307429
15MAPK151.48275053
16MST1R1.47893151
17PDK11.45925585
18PDPK11.40569762
19WNK11.34408591
20NEK61.27618911
21DYRK1B1.08295416
22PINK11.03082612
23CDK70.97553230
24MAP2K70.86952003
25FRK0.85818794
26CDK120.76524854
27SIK20.74769134
28TRIM280.72533513
29PRKG20.72265339
30MAP3K40.72167193
31PRKG10.66778890
32MARK10.66061197
33BMPR1B0.65529083
34LATS10.63540540
35TIE10.59642817
36TYRO30.59100329
37UHMK10.55790783
38AKT30.54370483
39PRKAA20.53262821
40MARK30.53061104
41CAMK1D0.50381645
42MUSK0.50307411
43SGK4940.49883355
44SGK2230.49883355
45FER0.49782353
46ROCK10.49623580
47ADRBK20.48420314
48DYRK30.46512376
49WNK40.45689463
50CDK30.45169936
51CAMK10.44802200
52MAP2K20.42135133
53CAMK40.40077704
54MAP3K90.39912600
55KSR20.39531771
56STK390.38234998
57MAPK130.36349225
58PRKCG0.34779199
59MAPK10.34022325
60GSK3B0.33942188
61TESK20.33348102
62PRKCZ0.33201692
63OXSR10.33196579
64CDK10.33060836
65LATS20.30847044
66RPS6KA10.30846005
67ERBB30.30140617
68PRKCE0.29991450
69MYLK0.29440914
70RPS6KA20.28645982
71CDK20.28474927
72PRKCB0.27320994
73BCR0.26711739
74SGK20.25534530
75MAPK80.23304037
76MAP3K80.23216841
77SGK10.22880323
78ZAK0.22016159
79CAMK2A0.21527602
80TXK0.21317370
81CDK190.20704757
82BRAF0.20546688
83MAPK140.19869415
84WNK30.19778499
85CHUK0.19650690
86MINK10.19165744
87PKN10.17882303
88MAP3K20.17592159
89CSNK1A10.17139060
90MAPK100.16722120
91CSNK1D0.15987781
92CHEK10.15974509
93MAP2K10.15262634
94PRKACB0.14885674
95OBSCN0.14796936
96MET0.14218273
97MAP3K10.13701962
98PRKACA0.11854787
99BLK0.11501619
100MAP3K110.10844710

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.03986598
2Fatty acid biosynthesis_Homo sapiens_hsa000615.62588614
3Olfactory transduction_Homo sapiens_hsa047404.23761108
4Butanoate metabolism_Homo sapiens_hsa006503.00067238
5Taste transduction_Homo sapiens_hsa047422.08619332
6Glycerophospholipid metabolism_Homo sapiens_hsa005641.87396340
7Phototransduction_Homo sapiens_hsa047441.66885462
8Dorso-ventral axis formation_Homo sapiens_hsa043201.65779565
9RNA transport_Homo sapiens_hsa030131.60635222
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55486855
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39690811
12Phenylalanine metabolism_Homo sapiens_hsa003601.39331903
13Type II diabetes mellitus_Homo sapiens_hsa049301.34609061
14Type I diabetes mellitus_Homo sapiens_hsa049401.34024629
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33878990
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31555867
17Fatty acid metabolism_Homo sapiens_hsa012121.31487620
18Antigen processing and presentation_Homo sapiens_hsa046121.29825595
19Fatty acid degradation_Homo sapiens_hsa000711.24894951
20Morphine addiction_Homo sapiens_hsa050321.18153772
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15460027
22Salivary secretion_Homo sapiens_hsa049701.14732810
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14335300
24Endocytosis_Homo sapiens_hsa041441.12796704
25Inositol phosphate metabolism_Homo sapiens_hsa005621.10666002
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07796184
27Circadian entrainment_Homo sapiens_hsa047131.07553761
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.06300953
29Allograft rejection_Homo sapiens_hsa053301.03687886
30Arginine and proline metabolism_Homo sapiens_hsa003301.02770888
31Autoimmune thyroid disease_Homo sapiens_hsa053201.01136391
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00421698
33Oocyte meiosis_Homo sapiens_hsa041140.99295160
34Nitrogen metabolism_Homo sapiens_hsa009100.94317992
35Graft-versus-host disease_Homo sapiens_hsa053320.93218639
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91861865
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91593988
38Calcium signaling pathway_Homo sapiens_hsa040200.90307950
39cAMP signaling pathway_Homo sapiens_hsa040240.90003173
40Nicotine addiction_Homo sapiens_hsa050330.87395087
41Viral myocarditis_Homo sapiens_hsa054160.87223301
42Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87150385
43Renin secretion_Homo sapiens_hsa049240.85214152
44Adipocytokine signaling pathway_Homo sapiens_hsa049200.83943765
45Serotonergic synapse_Homo sapiens_hsa047260.83131461
46Synaptic vesicle cycle_Homo sapiens_hsa047210.82507454
47GABAergic synapse_Homo sapiens_hsa047270.82490290
48ABC transporters_Homo sapiens_hsa020100.81716133
49Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81274865
50Glutamatergic synapse_Homo sapiens_hsa047240.80421937
51Arginine biosynthesis_Homo sapiens_hsa002200.79549981
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76398046
53Retinol metabolism_Homo sapiens_hsa008300.75196385
54PPAR signaling pathway_Homo sapiens_hsa033200.74650208
55Insulin secretion_Homo sapiens_hsa049110.72564123
56Propanoate metabolism_Homo sapiens_hsa006400.72234720
57Glycerolipid metabolism_Homo sapiens_hsa005610.71256177
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.71207764
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.66922112
60Tyrosine metabolism_Homo sapiens_hsa003500.66106740
61Fat digestion and absorption_Homo sapiens_hsa049750.65720154
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63772601
63Basal transcription factors_Homo sapiens_hsa030220.62563581
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62071209
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60568278
66Gastric acid secretion_Homo sapiens_hsa049710.59576241
67Hedgehog signaling pathway_Homo sapiens_hsa043400.59303366
68Fanconi anemia pathway_Homo sapiens_hsa034600.57981652
69beta-Alanine metabolism_Homo sapiens_hsa004100.57552400
70Circadian rhythm_Homo sapiens_hsa047100.54184502
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53529843
72Influenza A_Homo sapiens_hsa051640.52963794
73Cholinergic synapse_Homo sapiens_hsa047250.52429003
74Estrogen signaling pathway_Homo sapiens_hsa049150.49772937
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49424897
76Protein digestion and absorption_Homo sapiens_hsa049740.49057737
77Pancreatic secretion_Homo sapiens_hsa049720.48761698
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47162988
79Platelet activation_Homo sapiens_hsa046110.45322552
80Chemical carcinogenesis_Homo sapiens_hsa052040.42875171
81Vitamin B6 metabolism_Homo sapiens_hsa007500.42217895
82Purine metabolism_Homo sapiens_hsa002300.40827363
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.39571329
84Amphetamine addiction_Homo sapiens_hsa050310.38168380
85Gap junction_Homo sapiens_hsa045400.37440178
86Legionellosis_Homo sapiens_hsa051340.35925119
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35761085
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.35589379
89Tight junction_Homo sapiens_hsa045300.33068631
90Oxytocin signaling pathway_Homo sapiens_hsa049210.32631569
91Bile secretion_Homo sapiens_hsa049760.31299443
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30629303
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30592801
94Long-term potentiation_Homo sapiens_hsa047200.30544643
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29265676
96Cardiac muscle contraction_Homo sapiens_hsa042600.28937846
97Long-term depression_Homo sapiens_hsa047300.24227728
98Herpes simplex infection_Homo sapiens_hsa051680.23547811
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23242547
100ECM-receptor interaction_Homo sapiens_hsa045120.21630129

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