ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.59740644
2	behavioral response to nicotine (GO:0035095)	5.47226729
3	L-fucose metabolic process (GO:0042354)	5.36348243
4	L-fucose catabolic process (GO:0042355)	5.36348243
5	fucose catabolic process (GO:0019317)	5.36348243
6	cell wall macromolecule catabolic process (GO:0016998)	5.08705538
7	cell wall macromolecule metabolic process (GO:0044036)	4.78290382
8	indole-containing compound catabolic process (GO:0042436)	4.29454318
9	indolalkylamine catabolic process (GO:0046218)	4.29454318
10	tryptophan catabolic process (GO:0006569)	4.29454318
11	cellular ketone body metabolic process (GO:0046950)	4.26368695
12	kynurenine metabolic process (GO:0070189)	4.06779590
13	tryptophan metabolic process (GO:0006568)	4.03190727
14	indolalkylamine metabolic process (GO:0006586)	3.90573959
15	ketone body metabolic process (GO:1902224)	3.81333300
16	platelet dense granule organization (GO:0060155)	3.76747016
17	water-soluble vitamin biosynthetic process (GO:0042364)	3.70982518
18	gamma-aminobutyric acid transport (GO:0015812)	3.67633128
19	S-adenosylmethionine metabolic process (GO:0046500)	3.55940822
20	protein polyglutamylation (GO:0018095)	3.53617045
21	sperm motility (GO:0030317)	3.53304184
22	drug catabolic process (GO:0042737)	3.50249039
23	axoneme assembly (GO:0035082)	3.48123664
24	detection of light stimulus involved in visual perception (GO:0050908)	3.33737472
25	detection of light stimulus involved in sensory perception (GO:0050962)	3.33737472
26	protein-cofactor linkage (GO:0018065)	3.27169490
27	ubiquinone biosynthetic process (GO:0006744)	3.25146598
28	exogenous drug catabolic process (GO:0042738)	3.21637338
29	neuronal action potential (GO:0019228)	3.21256712
30	indole-containing compound metabolic process (GO:0042430)	3.21029721
31	nucleoside transmembrane transport (GO:1901642)	3.19913334
32	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.15408517
33	positive regulation of action potential (GO:0045760)	3.12624056
34	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.08745541
35	regulation of cilium movement (GO:0003352)	3.08265793
36	piRNA metabolic process (GO:0034587)	3.08023531
37	negative regulation of telomere maintenance (GO:0032205)	3.05989915
38	cilium or flagellum-dependent cell motility (GO:0001539)	3.05891586
39	multicellular organism reproduction (GO:0032504)	3.04252857
40	reflex (GO:0060004)	3.04215013
41	ubiquinone metabolic process (GO:0006743)	3.03688767
42	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.03457445
43	fucosylation (GO:0036065)	3.03309456
44	cornea development in camera-type eye (GO:0061303)	3.03085943
45	primary amino compound metabolic process (GO:1901160)	3.02860863
46	nonmotile primary cilium assembly (GO:0035058)	3.00812844
47	oxidative demethylation (GO:0070989)	2.99798931
48	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.99557038
49	proline transport (GO:0015824)	2.98799663
50	acrosome reaction (GO:0007340)	2.97609714
51	regulation of action potential (GO:0098900)	2.96952575
52	cellular response to ATP (GO:0071318)	2.95624522
53	epithelial cilium movement (GO:0003351)	2.95208982
54	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.91506077
55	negative regulation of T cell differentiation in thymus (GO:0033085)	2.86752549
56	cellular biogenic amine catabolic process (GO:0042402)	2.86182837
57	amine catabolic process (GO:0009310)	2.86182837
58	quinone biosynthetic process (GO:1901663)	2.78738973
59	DNA deamination (GO:0045006)	2.77422482
60	auditory receptor cell stereocilium organization (GO:0060088)	2.74968861
61	synaptic transmission, cholinergic (GO:0007271)	2.74598092
62	neuronal action potential propagation (GO:0019227)	2.71090612
63	DNA double-strand break processing (GO:0000729)	2.70304952
64	lysine catabolic process (GO:0006554)	2.70041645
65	lysine metabolic process (GO:0006553)	2.70041645
66	glycine transport (GO:0015816)	2.69116286
67	aromatic amino acid family catabolic process (GO:0009074)	2.67706846
68	synapsis (GO:0007129)	2.66918844
69	male meiosis I (GO:0007141)	2.66335117
70	negative regulation of mast cell activation (GO:0033004)	2.66248899
71	behavioral response to ethanol (GO:0048149)	2.66227898
72	retinal cone cell development (GO:0046549)	2.65685758
73	amino acid salvage (GO:0043102)	2.64971075
74	L-methionine salvage (GO:0071267)	2.64971075
75	L-methionine biosynthetic process (GO:0071265)	2.64971075
76	fusion of sperm to egg plasma membrane (GO:0007342)	2.62255901
77	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.62134494
78	arginine metabolic process (GO:0006525)	2.62018260
79	regulation of microtubule-based movement (GO:0060632)	2.61969293
80	axonemal dynein complex assembly (GO:0070286)	2.61161039
81	DNA methylation involved in gamete generation (GO:0043046)	2.59803423
82	respiratory chain complex IV assembly (GO:0008535)	2.59297642
83	positive regulation of mitochondrial fission (GO:0090141)	2.58761307
84	organic cation transport (GO:0015695)	2.57702108
85	protein complex biogenesis (GO:0070271)	2.57547639
86	cilium organization (GO:0044782)	2.57212738
87	regulation of meiosis I (GO:0060631)	2.57063691
88	sulfation (GO:0051923)	2.56719011
89	cysteine metabolic process (GO:0006534)	2.56492152
90	aspartate family amino acid catabolic process (GO:0009068)	2.53995659
91	regulation of centriole replication (GO:0046599)	2.53783066
92	establishment of protein localization to Golgi (GO:0072600)	2.53193542
93	protein K11-linked deubiquitination (GO:0035871)	2.53186221
94	fucose metabolic process (GO:0006004)	2.51452868
95	cilium assembly (GO:0042384)	2.50480489
96	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.50471079
97	protein targeting to Golgi (GO:0000042)	2.48632595
98	protein import into peroxisome matrix (GO:0016558)	2.47419927
99	seminiferous tubule development (GO:0072520)	2.47379399
100	mitochondrial respiratory chain complex assembly (GO:0033108)	2.45852209

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.10084622
2	VDR_22108803_ChIP-Seq_LS180_Human	3.59751338
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.99103649
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.92583112
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.92344678
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48441337
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.47134043
8	FUS_26573619_Chip-Seq_HEK293_Human	2.36811571
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.33114135
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.31330880
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.28847175
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.24729493
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.11198977
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06663186
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04885149
16	EWS_26573619_Chip-Seq_HEK293_Human	2.00105474
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00016403
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.97180240
19	P300_19829295_ChIP-Seq_ESCs_Human	1.95770258
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94181654
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.84362668
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83864438
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.79166384
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.68734081
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61095159
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.58126122
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.57801619
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57801619
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.49785267
30	STAT3_23295773_ChIP-Seq_U87_Human	1.48795799
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47840043
32	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.47413299
33	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.45864716
34	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.45005905
35	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.44764419
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44646372
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44646372
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.42713485
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.41754877
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.41754877
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.41130844
42	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.40405666
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.39427365
44	AR_25329375_ChIP-Seq_VCAP_Human	1.39175637
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.38863126
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38761062
47	TCF4_23295773_ChIP-Seq_U87_Human	1.35919527
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35356188
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35356188
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35226218
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34137956
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.33169412
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.33148533
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33145211
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.31967284
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31875317
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31487665
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.31132973
59	MYC_18940864_ChIP-ChIP_HL60_Human	1.29634409
60	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.28452120
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28368861
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27420375
63	REST_21632747_ChIP-Seq_MESCs_Mouse	1.27254687
64	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.26601073
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24760272
66	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.24499016
67	NCOR_22424771_ChIP-Seq_293T_Human	1.22304458
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21925823
69	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21502168
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21466387
71	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.21058584
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19325392
73	AR_20517297_ChIP-Seq_VCAP_Human	1.19109989
74	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17418854
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16886632
76	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14860198
77	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.13794111
78	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12674634
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12663811
80	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11853485
81	MYC_19829295_ChIP-Seq_ESCs_Human	1.09950991
82	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.09770069
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09411623
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07092852
85	TAF2_19829295_ChIP-Seq_ESCs_Human	1.04974196
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04545927
87	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03514377
88	ERA_21632823_ChIP-Seq_H3396_Human	1.03343378
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02095348
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00755886
91	CDX2_22108803_ChIP-Seq_LS180_Human	1.00497792
92	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00416179
93	ETV1_20927104_ChIP-Seq_GIST48_Human	0.99408695
94	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.99247929
95	IRF1_19129219_ChIP-ChIP_H3396_Human	0.98834808
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98832670
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.97636343
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.95968733
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95906919
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.95624684

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.04487123
2	MP0003787_abnormal_imprinting	2.75806862
3	MP0008875_abnormal_xenobiotic_pharmacok	2.66859063
4	MP0008877_abnormal_DNA_methylation	2.54062665
5	MP0002837_dystrophic_cardiac_calcinosis	2.40132217
6	MP0005551_abnormal_eye_electrophysiolog	2.35697832
7	MP0002102_abnormal_ear_morphology	2.32928151
8	MP0005410_abnormal_fertilization	2.32497093
9	MP0003195_calcinosis	2.27829190
10	MP0001968_abnormal_touch/_nociception	2.23024099
11	MP0003718_maternal_effect	2.20614569
12	MP0005645_abnormal_hypothalamus_physiol	2.06315904
13	MP0001986_abnormal_taste_sensitivity	2.01188561
14	MP0004142_abnormal_muscle_tone	1.99915047
15	MP0003011_delayed_dark_adaptation	1.94907990
16	MP0002876_abnormal_thyroid_physiology	1.93569487
17	MP0009745_abnormal_behavioral_response	1.92174816
18	MP0002138_abnormal_hepatobiliary_system	1.89812874
19	MP0001501_abnormal_sleep_pattern	1.86136171
20	MP0004145_abnormal_muscle_electrophysio	1.85915658
21	MP0009046_muscle_twitch	1.83519493
22	MP0002272_abnormal_nervous_system	1.70308923
23	MP0003806_abnormal_nucleotide_metabolis	1.65716797
24	MP0008872_abnormal_physiological_respon	1.64795123
25	MP0001188_hyperpigmentation	1.62612863
26	MP0001984_abnormal_olfaction	1.54725595
27	MP0001529_abnormal_vocalization	1.50213437
28	MP0005253_abnormal_eye_physiology	1.49730784
29	MP0003880_abnormal_central_pattern	1.49623111
30	MP0004215_abnormal_myocardial_fiber	1.49177856
31	MP0004885_abnormal_endolymph	1.47891002
32	MP0003136_yellow_coat_color	1.45002987
33	MP0005084_abnormal_gallbladder_morpholo	1.42397107
34	MP0002736_abnormal_nociception_after	1.39005345
35	MP0005365_abnormal_bile_salt	1.38168061
36	MP0006072_abnormal_retinal_apoptosis	1.37140682
37	MP0002653_abnormal_ependyma_morphology	1.36770184
38	MP0002733_abnormal_thermal_nociception	1.35801857
39	MP0001485_abnormal_pinna_reflex	1.35574810
40	MP0004043_abnormal_pH_regulation	1.35386713
41	MP0001486_abnormal_startle_reflex	1.34066033
42	MP0005646_abnormal_pituitary_gland	1.33292015
43	MP0003698_abnormal_male_reproductive	1.32364583
44	MP0006276_abnormal_autonomic_nervous	1.32242080
45	MP0005174_abnormal_tail_pigmentation	1.32181088
46	MP0000569_abnormal_digit_pigmentation	1.28796081
47	MP0005085_abnormal_gallbladder_physiolo	1.27861473
48	MP0000427_abnormal_hair_cycle	1.27040080
49	MP0008775_abnormal_heart_ventricle	1.26618985
50	MP0002139_abnormal_hepatobiliary_system	1.26228955
51	MP0002064_seizures	1.25304319
52	MP0002638_abnormal_pupillary_reflex	1.22875525
53	MP0001764_abnormal_homeostasis	1.22181954
54	MP0002734_abnormal_mechanical_nocicepti	1.21275451
55	MP0004484_altered_response_of	1.21011969
56	MP0002735_abnormal_chemical_nociception	1.19495210
57	MP0000372_irregular_coat_pigmentation	1.19176746
58	MP0001929_abnormal_gametogenesis	1.16703162
59	MP0000631_abnormal_neuroendocrine_gland	1.13527451
60	MP0002572_abnormal_emotion/affect_behav	1.13365142
61	MP0001970_abnormal_pain_threshold	1.13026749
62	MP0008995_early_reproductive_senescence	1.10080016
63	MP0002160_abnormal_reproductive_system	1.09487564
64	MP0005423_abnormal_somatic_nervous	1.08490227
65	MP0005332_abnormal_amino_acid	1.05086810
66	MP0004742_abnormal_vestibular_system	1.04172766
67	MP0010386_abnormal_urinary_bladder	1.03916856
68	MP0003635_abnormal_synaptic_transmissio	1.03528408
69	MP0004924_abnormal_behavior	1.03247662
70	MP0005386_behavior/neurological_phenoty	1.03247662
71	MP0004133_heterotaxia	1.02268113
72	MP0002067_abnormal_sensory_capabilities	1.01818590
73	MP0004147_increased_porphyrin_level	0.97099400
74	MP0009780_abnormal_chondrocyte_physiolo	0.96735430
75	MP0002557_abnormal_social/conspecific_i	0.94940876
76	MP0000013_abnormal_adipose_tissue	0.94265023
77	MP0002229_neurodegeneration	0.93557940
78	MP0002063_abnormal_learning/memory/cond	0.92151820
79	MP0003121_genomic_imprinting	0.92054799
80	MP0003137_abnormal_impulse_conducting	0.91794387
81	MP0002234_abnormal_pharynx_morphology	0.91794224
82	MP0006036_abnormal_mitochondrial_physio	0.91278395
83	MP0002254_reproductive_system_inflammat	0.90659565
84	MP0005377_hearing/vestibular/ear_phenot	0.90407419
85	MP0003878_abnormal_ear_physiology	0.90407419
86	MP0000230_abnormal_systemic_arterial	0.89862891
87	MP0001905_abnormal_dopamine_level	0.89760097
88	MP0002938_white_spotting	0.89242457
89	MP0004085_abnormal_heartbeat	0.89067433
90	MP0006292_abnormal_olfactory_placode	0.88861400
91	MP0003172_abnormal_lysosome_physiology	0.88052390
92	MP0002184_abnormal_innervation	0.87022689
93	MP0005389_reproductive_system_phenotype	0.86532762
94	MP0004270_analgesia	0.86525364
95	MP0010329_abnormal_lipoprotein_level	0.86476161
96	MP0002095_abnormal_skin_pigmentation	0.85552261
97	MP0001502_abnormal_circadian_rhythm	0.83831335
98	MP0005167_abnormal_blood-brain_barrier	0.79711041
99	MP0002210_abnormal_sex_determination	0.78724137
100	MP0000015_abnormal_ear_pigmentation	0.78546193

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.57949433
2	Abnormality of midbrain morphology (HP:0002418)	4.02942130
3	Molar tooth sign on MRI (HP:0002419)	4.02942130
4	Pancreatic fibrosis (HP:0100732)	3.90129325
5	Chronic hepatic failure (HP:0100626)	3.70380699
6	True hermaphroditism (HP:0010459)	3.64974851
7	Congenital stationary night blindness (HP:0007642)	3.41039801
8	Attenuation of retinal blood vessels (HP:0007843)	3.31726742
9	Nephronophthisis (HP:0000090)	3.21637417
10	Abnormality of alanine metabolism (HP:0010916)	3.21309251
11	Hyperalaninemia (HP:0003348)	3.21309251
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.21309251
13	Inability to walk (HP:0002540)	3.19195834
14	Type II lissencephaly (HP:0007260)	3.12397339
15	Abnormality of the renal cortex (HP:0011035)	2.98994832
16	Abnormality of the renal medulla (HP:0100957)	2.84928484
17	Abolished electroretinogram (ERG) (HP:0000550)	2.82543660
18	Tubular atrophy (HP:0000092)	2.81365011
19	Pendular nystagmus (HP:0012043)	2.70689332
20	Hyperventilation (HP:0002883)	2.69745741
21	Medial flaring of the eyebrow (HP:0010747)	2.65180374
22	Cystic liver disease (HP:0006706)	2.60223910
23	Abnormal drinking behavior (HP:0030082)	2.58891053
24	Polydipsia (HP:0001959)	2.58891053
25	Hypothermia (HP:0002045)	2.52847653
26	Methylmalonic acidemia (HP:0002912)	2.52677655
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.52403374
28	Absent/shortened dynein arms (HP:0200106)	2.52403374
29	Oligodactyly (hands) (HP:0001180)	2.51382490
30	Abnormal pancreas size (HP:0012094)	2.44634317
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.44314130
32	Hyperglycinuria (HP:0003108)	2.39182727
33	Progressive inability to walk (HP:0002505)	2.38853414
34	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.38761737
35	Retinal dysplasia (HP:0007973)	2.37201561
36	Anophthalmia (HP:0000528)	2.36475408
37	Bile duct proliferation (HP:0001408)	2.35490279
38	Abnormal biliary tract physiology (HP:0012439)	2.35490279
39	Lissencephaly (HP:0001339)	2.33491892
40	Abnormality of glycine metabolism (HP:0010895)	2.33385990
41	Abnormality of serine family amino acid metabolism (HP:0010894)	2.33385990
42	Decreased central vision (HP:0007663)	2.29547623
43	Sclerocornea (HP:0000647)	2.24037314
44	Furrowed tongue (HP:0000221)	2.22000214
45	Hyperglycinemia (HP:0002154)	2.17604413
46	Gait imbalance (HP:0002141)	2.17032819
47	Abnormal respiratory epithelium morphology (HP:0012253)	2.16915238
48	Abnormal respiratory motile cilium morphology (HP:0005938)	2.16915238
49	Polyuria (HP:0000103)	2.14903549
50	Congenital hepatic fibrosis (HP:0002612)	2.11571379
51	Congenital primary aphakia (HP:0007707)	2.08827486
52	Anencephaly (HP:0002323)	2.08432467
53	Large for gestational age (HP:0001520)	2.08306423
54	Febrile seizures (HP:0002373)	2.08271857
55	Methylmalonic aciduria (HP:0012120)	2.04173398
56	Nephrogenic diabetes insipidus (HP:0009806)	2.01719498
57	Ketosis (HP:0001946)	1.99535381
58	Chorioretinal atrophy (HP:0000533)	1.98858896
59	Gaze-evoked nystagmus (HP:0000640)	1.96534453
60	Type 2 muscle fiber atrophy (HP:0003554)	1.96079726
61	Congenital sensorineural hearing impairment (HP:0008527)	1.95447883
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.94369942
63	Broad-based gait (HP:0002136)	1.93331128
64	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91815629
65	Abnormal urine output (HP:0012590)	1.91576136
66	Bony spicule pigmentary retinopathy (HP:0007737)	1.89424052
67	Occipital encephalocele (HP:0002085)	1.87642766
68	Lipid accumulation in hepatocytes (HP:0006561)	1.87139639
69	Postaxial foot polydactyly (HP:0001830)	1.86364550
70	Hemiparesis (HP:0001269)	1.86220869
71	Abnormality of macular pigmentation (HP:0008002)	1.85864871
72	Male pseudohermaphroditism (HP:0000037)	1.85704510
73	Hypomagnesemia (HP:0002917)	1.85472036
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.82274006
75	Genital tract atresia (HP:0001827)	1.81390389
76	Glycosuria (HP:0003076)	1.81222048
77	Abnormality of urine glucose concentration (HP:0011016)	1.81222048
78	Vaginal atresia (HP:0000148)	1.79218698
79	Optic nerve hypoplasia (HP:0000609)	1.77458720
80	Postaxial hand polydactyly (HP:0001162)	1.77397430
81	Abnormality of serum amino acid levels (HP:0003112)	1.76631122
82	Optic disc pallor (HP:0000543)	1.76348113
83	Cerebellar dysplasia (HP:0007033)	1.75896701
84	Abnormality of the labia minora (HP:0012880)	1.75257856
85	Severe muscular hypotonia (HP:0006829)	1.75055199
86	Abnormality of renal excretion (HP:0011036)	1.74847210
87	Hypoalbuminemia (HP:0003073)	1.74530009
88	Abnormal albumin level (HP:0012116)	1.74530009
89	Polyphagia (HP:0002591)	1.73831766
90	Stomatitis (HP:0010280)	1.72901739
91	Pachygyria (HP:0001302)	1.72740235
92	Increased CSF lactate (HP:0002490)	1.70895891
93	Ketoacidosis (HP:0001993)	1.70043597
94	Abnormal ciliary motility (HP:0012262)	1.69519514
95	Generalized myoclonic seizures (HP:0002123)	1.69038047
96	Abnormality of vitamin B metabolism (HP:0004340)	1.67189659
97	Acute encephalopathy (HP:0006846)	1.67173614
98	Renal cortical cysts (HP:0000803)	1.66828726
99	Thyroid-stimulating hormone excess (HP:0002925)	1.65667688
100	Abnormal respiratory motile cilium physiology (HP:0012261)	1.64108536

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.11697817
2	MAP4K2	3.28013766
3	PINK1	3.21418972
4	BMPR1B	2.88178335
5	GRK1	2.70827205
6	ZAK	2.49085155
7	ADRBK2	2.46814880
8	WNK3	2.32715760
9	WNK4	2.21050608
10	INSRR	2.11758159
11	MAP3K4	2.09744868
12	MAPK13	2.07524753
13	NUAK1	2.06442699
14	EIF2AK3	1.98545457
15	STK16	1.96748486
16	PHKG1	1.92106013
17	PHKG2	1.92106013
18	OBSCN	1.91056046
19	ACVR1B	1.86721585
20	TAOK3	1.83108199
21	PLK4	1.68168123
22	BCKDK	1.66389055
23	TLK1	1.64015569
24	DAPK2	1.62463723
25	TNIK	1.59394355
26	MAP2K7	1.57303196
27	OXSR1	1.55294915
28	TRIM28	1.41907493
29	PLK2	1.35132013
30	STK39	1.26626446
31	CASK	1.26519007
32	MARK1	1.25499789
33	DYRK2	1.21053891
34	PIK3CG	1.17637185
35	PRKCE	1.15919739
36	TIE1	1.12469306
37	ERBB3	1.09529057
38	VRK1	1.09076811
39	TGFBR1	1.07413966
40	PAK3	1.05887453
41	MST4	1.00027645
42	BCR	0.98716308
43	CAMKK2	0.97780815
44	CSNK1G2	0.97387586
45	PRKCG	0.96389469
46	MKNK2	0.96179724
47	MAP2K6	0.93846256
48	MAPKAPK3	0.86088476
49	STK38L	0.85090729
50	CSNK1G3	0.83881260
51	CSNK1G1	0.82607838
52	ADRBK1	0.82077438
53	PTK2B	0.79693241
54	EPHA3	0.76612502
55	MKNK1	0.73988203
56	MAPK15	0.73828099
57	MAP2K4	0.72635467
58	MAPKAPK5	0.71451882
59	PNCK	0.70432408
60	PRKCQ	0.68197227
61	PLK3	0.65324741
62	CAMK2A	0.63274862
63	NLK	0.62851534
64	TSSK6	0.61980450
65	PRKCI	0.60108565
66	CSNK1A1L	0.58374191
67	NME1	0.58012068
68	RPS6KA5	0.56698736
69	FER	0.53477901
70	AKT3	0.49047549
71	KIT	0.48449965
72	CSNK1A1	0.46974155
73	NTRK2	0.46509348
74	PRKACA	0.45895210
75	TRPM7	0.44785064
76	PRKAA2	0.44736048
77	TXK	0.44215967
78	PRKG1	0.42782076
79	PKN1	0.41066878
80	CAMK4	0.40304538
81	TEC	0.39480677
82	SYK	0.39383096
83	PAK6	0.37920254
84	BRSK2	0.37782182
85	PRKCZ	0.37762224
86	PIK3CA	0.37085499
87	PRKCA	0.36305339
88	IRAK1	0.35247390
89	RPS6KA6	0.34011176
90	CAMK1	0.33431088
91	MUSK	0.32533903
92	PRKAA1	0.31311554
93	VRK2	0.28669500
94	PLK1	0.28623412
95	IKBKB	0.27403634
96	PRKACB	0.27141337
97	CAMK2D	0.26586232
98	TAF1	0.25487490
99	ITK	0.25473695
100	IGF1R	0.24404526

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	2.94331697
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.85651714
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.64699679
4	Butanoate metabolism_Homo sapiens_hsa00650	2.62018283
5	Phototransduction_Homo sapiens_hsa04744	2.57607365
6	Caffeine metabolism_Homo sapiens_hsa00232	2.56420363
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.52929206
8	Tryptophan metabolism_Homo sapiens_hsa00380	2.35398350
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.33935145
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.18317635
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.14657307
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.83917839
13	Propanoate metabolism_Homo sapiens_hsa00640	1.77262190
14	Nicotine addiction_Homo sapiens_hsa05033	1.75667315
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.71667224
16	Ether lipid metabolism_Homo sapiens_hsa00565	1.68022437
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.62467801
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.57341674
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.56550332
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.54092533
21	Protein export_Homo sapiens_hsa03060	1.53761064
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.50386049
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.49541613
24	Asthma_Homo sapiens_hsa05310	1.43797697
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.43583477
26	Basal transcription factors_Homo sapiens_hsa03022	1.42040088
27	Regulation of autophagy_Homo sapiens_hsa04140	1.36733943
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.33081200
29	Sulfur metabolism_Homo sapiens_hsa00920	1.28866843
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.26925151
31	Peroxisome_Homo sapiens_hsa04146	1.26680794
32	Fatty acid degradation_Homo sapiens_hsa00071	1.24812685
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.23831717
34	Olfactory transduction_Homo sapiens_hsa04740	1.21865884
35	Retinol metabolism_Homo sapiens_hsa00830	1.20309147
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.19292974
37	Homologous recombination_Homo sapiens_hsa03440	1.16412543
38	Parkinsons disease_Homo sapiens_hsa05012	1.15436273
39	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.13915581
40	Taste transduction_Homo sapiens_hsa04742	1.13312780
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12611480
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.11349894
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.06222499
44	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.05036289
45	Cardiac muscle contraction_Homo sapiens_hsa04260	1.04270033
46	Fat digestion and absorption_Homo sapiens_hsa04975	1.03288423
47	RNA polymerase_Homo sapiens_hsa03020	0.99889851
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.99888591
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99056384
50	One carbon pool by folate_Homo sapiens_hsa00670	0.97167634
51	Graft-versus-host disease_Homo sapiens_hsa05332	0.96308558
52	Allograft rejection_Homo sapiens_hsa05330	0.95282753
53	Insulin secretion_Homo sapiens_hsa04911	0.94862933
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.94663806
55	Serotonergic synapse_Homo sapiens_hsa04726	0.93184032
56	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.91556885
57	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.90298613
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.88353944
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.86586197
60	GABAergic synapse_Homo sapiens_hsa04727	0.86347221
61	Histidine metabolism_Homo sapiens_hsa00340	0.85473843
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83812375
63	Circadian entrainment_Homo sapiens_hsa04713	0.81737893
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.81669198
65	Morphine addiction_Homo sapiens_hsa05032	0.78232965
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.77536342
67	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.74877610
68	Purine metabolism_Homo sapiens_hsa00230	0.74461251
69	Fanconi anemia pathway_Homo sapiens_hsa03460	0.74301205
70	Salivary secretion_Homo sapiens_hsa04970	0.72338944
71	Glutamatergic synapse_Homo sapiens_hsa04724	0.72134585
72	RNA degradation_Homo sapiens_hsa03018	0.72090857
73	Huntingtons disease_Homo sapiens_hsa05016	0.71698270
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.68175659
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66015864
76	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.63868147
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.62628301
78	ABC transporters_Homo sapiens_hsa02010	0.62468571
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61988927
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.61639350
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61566709
82	Metabolic pathways_Homo sapiens_hsa01100	0.60672302
83	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.60580890
84	Alzheimers disease_Homo sapiens_hsa05010	0.57626607
85	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56143438
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54730385
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53074840
88	Long-term depression_Homo sapiens_hsa04730	0.52731778
89	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.52200497
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.51949468
91	Mineral absorption_Homo sapiens_hsa04978	0.50207231
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.42971528
93	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.42618535
94	Arginine biosynthesis_Homo sapiens_hsa00220	0.42457660
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.40057523
96	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.39413342
97	Bile secretion_Homo sapiens_hsa04976	0.38636086
98	Circadian rhythm_Homo sapiens_hsa04710	0.37337508
99	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36535172
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35971017

LRRC37A7P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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