ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	7.83888949
2	acrosome reaction (GO:0007340)	6.81012566
3	fusion of sperm to egg plasma membrane (GO:0007342)	6.30494263
4	response to pheromone (GO:0019236)	6.26164345
5	protein polyglutamylation (GO:0018095)	6.21151585
6	centriole replication (GO:0007099)	6.07312354
7	microtubule depolymerization (GO:0007019)	5.61368600
8	establishment of protein localization to Golgi (GO:0072600)	5.49290069
9	protein targeting to Golgi (GO:0000042)	5.45247887
10	multicellular organism reproduction (GO:0032504)	5.44228775
11	spermatid development (GO:0007286)	5.26499642
12	regulation of cilium movement (GO:0003352)	5.22792676
13	epithelial cilium movement (GO:0003351)	5.17012291
14	microtubule polymerization or depolymerization (GO:0031109)	4.98573914
15	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.96585894
16	axonemal dynein complex assembly (GO:0070286)	4.92769114
17	regulation of centriole replication (GO:0046599)	4.89170085
18	centriole assembly (GO:0098534)	4.84247044
19	plasma membrane fusion (GO:0045026)	4.81364971
20	single strand break repair (GO:0000012)	4.75627942
21	behavioral response to nicotine (GO:0035095)	4.71541952
22	sperm-egg recognition (GO:0035036)	4.68938741
23	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.46005207
24	cellular ketone body metabolic process (GO:0046950)	4.42065924
25	rRNA methylation (GO:0031167)	4.41831649
26	calcium ion-dependent exocytosis (GO:0017156)	4.38792036
27	sperm capacitation (GO:0048240)	4.37163145
28	protein localization to Golgi apparatus (GO:0034067)	4.27959210
29	cilium movement (GO:0003341)	4.25633878
30	reproduction (GO:0000003)	4.24391135
31	spermatogenesis (GO:0007283)	4.19399753
32	male gamete generation (GO:0048232)	4.19301146
33	seminiferous tubule development (GO:0072520)	4.16777844
34	cilium or flagellum-dependent cell motility (GO:0001539)	4.10068073
35	chromosome condensation (GO:0030261)	4.05801052
36	DNA packaging (GO:0006323)	4.02792211
37	ketone body metabolic process (GO:1902224)	3.98482230
38	rRNA modification (GO:0000154)	3.96060531
39	cell-cell recognition (GO:0009988)	3.87377870
40	gamete generation (GO:0007276)	3.86772695
41	organic cation transport (GO:0015695)	3.81332175
42	regulation of microtubule-based movement (GO:0060632)	3.78673523
43	spermatid nucleus differentiation (GO:0007289)	3.77272035
44	piRNA metabolic process (GO:0034587)	3.65628392
45	single fertilization (GO:0007338)	3.64109661
46	axoneme assembly (GO:0035082)	3.59322244
47	binding of sperm to zona pellucida (GO:0007339)	3.58763232
48	motile cilium assembly (GO:0044458)	3.57121886
49	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.51635755
50	male meiosis I (GO:0007141)	3.48488697
51	microtubule severing (GO:0051013)	3.33791020
52	phosphatidylethanolamine metabolic process (GO:0046337)	3.33721361
53	male meiosis (GO:0007140)	3.31579058
54	DNA methylation involved in gamete generation (GO:0043046)	3.27522828
55	fertilization (GO:0009566)	3.22025570
56	detection of light stimulus involved in visual perception (GO:0050908)	3.17729392
57	detection of light stimulus involved in sensory perception (GO:0050962)	3.17729392
58	spinal cord motor neuron differentiation (GO:0021522)	3.13795959
59	regulation of Rab GTPase activity (GO:0032313)	3.13281580
60	positive regulation of Rab GTPase activity (GO:0032851)	3.13281580
61	L-fucose catabolic process (GO:0042355)	3.07709577
62	fucose catabolic process (GO:0019317)	3.07709577
63	L-fucose metabolic process (GO:0042354)	3.07709577
64	RNA destabilization (GO:0050779)	3.03773385
65	primary amino compound metabolic process (GO:1901160)	3.03012660
66	germ cell development (GO:0007281)	3.02766981
67	multicellular organismal reproductive process (GO:0048609)	3.02019913
68	cilium organization (GO:0044782)	3.01731112
69	cell wall macromolecule metabolic process (GO:0044036)	2.98168453
70	cilium assembly (GO:0042384)	2.95935236
71	tryptophan catabolic process (GO:0006569)	2.95381008
72	indole-containing compound catabolic process (GO:0042436)	2.95381008
73	indolalkylamine catabolic process (GO:0046218)	2.95381008
74	synapsis (GO:0007129)	2.90688289
75	regulation of glucokinase activity (GO:0033131)	2.86866175
76	regulation of hexokinase activity (GO:1903299)	2.86866175
77	microtubule nucleation (GO:0007020)	2.85417540
78	indolalkylamine metabolic process (GO:0006586)	2.84884238
79	nephron tubule morphogenesis (GO:0072078)	2.84751366
80	nephron epithelium morphogenesis (GO:0072088)	2.84751366
81	cell wall macromolecule catabolic process (GO:0016998)	2.84672252
82	alanine transport (GO:0032328)	2.82110914
83	regulation of centrosome duplication (GO:0010824)	2.77582577
84	negative regulation of telomere maintenance (GO:0032205)	2.77325718
85	positive regulation of gastrulation (GO:2000543)	2.74412160
86	multicellular organismal movement (GO:0050879)	2.69366935
87	musculoskeletal movement (GO:0050881)	2.69366935
88	regulation of meiosis I (GO:0060631)	2.68281402
89	kynurenine metabolic process (GO:0070189)	2.67650606
90	cellular biogenic amine catabolic process (GO:0042402)	2.66802896
91	amine catabolic process (GO:0009310)	2.66802896
92	positive regulation of guanylate cyclase activity (GO:0031284)	2.64832200
93	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.63623544
94	DNA deamination (GO:0045006)	2.59417146
95	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.58581437
96	protein localization to cilium (GO:0061512)	2.57964231
97	nonmotile primary cilium assembly (GO:0035058)	2.57957751
98	cellular biogenic amine biosynthetic process (GO:0042401)	2.56965400
99	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.56753504
100	somite rostral/caudal axis specification (GO:0032525)	2.55106318

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.36151075
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.35480854
3	VDR_22108803_ChIP-Seq_LS180_Human	3.07869763
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.00875487
5	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.46277739
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.45632940
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.41160936
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35467406
9	FUS_26573619_Chip-Seq_HEK293_Human	2.34664249
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.32794930
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.12450836
12	ER_23166858_ChIP-Seq_MCF-7_Human	2.08643033
13	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.07804188
14	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.06455778
15	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.06455778
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.04115284
17	CBP_20019798_ChIP-Seq_JUKART_Human	2.00102361
18	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.00102361
19	P300_19829295_ChIP-Seq_ESCs_Human	1.91508300
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.80273907
21	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.74490143
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.71984612
23	TAF15_26573619_Chip-Seq_HEK293_Human	1.71951044
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.71486170
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.69059734
26	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.68724799
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.57620376
28	AR_25329375_ChIP-Seq_VCAP_Human	1.52674658
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.52584303
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.52321868
31	ERA_21632823_ChIP-Seq_H3396_Human	1.51108499
32	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.50655336
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50215775
34	STAT3_23295773_ChIP-Seq_U87_Human	1.49317474
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.49047513
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.47554623
37	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.47190150
38	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.44661310
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.43959793
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.43566284
41	IGF1R_20145208_ChIP-Seq_DFB_Human	1.41373980
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40691547
43	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.39888272
44	MYC_19829295_ChIP-Seq_ESCs_Human	1.39505343
45	NANOG_20526341_ChIP-Seq_ESCs_Human	1.37678965
46	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37459239
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.36401428
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36068504
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35014788
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35014788
51	TAF2_19829295_ChIP-Seq_ESCs_Human	1.33511609
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.33418853
53	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.33398483
54	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.32548359
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.31922900
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.31799778
57	EWS_26573619_Chip-Seq_HEK293_Human	1.31638780
58	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.31482507
59	TCF4_23295773_ChIP-Seq_U87_Human	1.31156028
60	NCOR_22424771_ChIP-Seq_293T_Human	1.30667555
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30257111
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30257111
63	RAC3_21632823_ChIP-Seq_H3396_Human	1.29971839
64	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.28757516
65	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28742001
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28377130
67	DROSHA_22980978_ChIP-Seq_HELA_Human	1.25870353
68	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.24442698
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24029001
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22845306
71	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.21951025
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.18460957
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18318554
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17210930
75	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.16994615
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.16929424
77	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.16348234
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14801502
79	OCT4_20526341_ChIP-Seq_ESCs_Human	1.14593737
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13872274
81	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.13528730
82	ETV1_20927104_ChIP-Seq_GIST48_Human	1.12683134
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.12379402
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12114733
85	TCF4_22108803_ChIP-Seq_LS180_Human	1.11920605
86	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11006164
87	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.10813421
88	RBPJ_21746931_ChIP-Seq_IB4_Human	1.10480845
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.10337621
90	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.10202881
91	RNF2_27304074_Chip-Seq_NSC_Mouse	1.09610890
92	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.09389282
93	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08313857
94	ERG_20517297_ChIP-Seq_VCAP_Human	1.06931956
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06417009
96	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06399351
97	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.05549829
98	NFYB_21822215_ChIP-Seq_K562_Human	1.04484310
99	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03770770
100	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03412429

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.00827030
2	MP0008877_abnormal_DNA_methylation	3.26481439
3	MP0005377_hearing/vestibular/ear_phenot	3.10226740
4	MP0003878_abnormal_ear_physiology	3.10226740
5	MP0003698_abnormal_male_reproductive	2.61746452
6	MP0001929_abnormal_gametogenesis	2.45378201
7	MP0006292_abnormal_olfactory_placode	2.24211548
8	MP0001968_abnormal_touch/_nociception	2.20883816
9	MP0005551_abnormal_eye_electrophysiolog	2.13302243
10	MP0003646_muscle_fatigue	2.12547672
11	MP0001485_abnormal_pinna_reflex	2.03158491
12	MP0003195_calcinosis	1.98046517
13	MP0002876_abnormal_thyroid_physiology	1.88415705
14	MP0004742_abnormal_vestibular_system	1.81824207
15	MP0003718_maternal_effect	1.79552248
16	MP0002102_abnormal_ear_morphology	1.78773127
17	MP0003011_delayed_dark_adaptation	1.76674478
18	MP0002735_abnormal_chemical_nociception	1.74158997
19	MP0003787_abnormal_imprinting	1.69774278
20	MP0002653_abnormal_ependyma_morphology	1.68123980
21	MP0001486_abnormal_startle_reflex	1.65674178
22	MP0003880_abnormal_central_pattern	1.62528833
23	MP0005253_abnormal_eye_physiology	1.62208287
24	MP0006276_abnormal_autonomic_nervous	1.59711691
25	MP0003283_abnormal_digestive_organ	1.55497607
26	MP0002138_abnormal_hepatobiliary_system	1.52154755
27	MP0008872_abnormal_physiological_respon	1.50644932
28	MP0002210_abnormal_sex_determination	1.50548353
29	MP0009745_abnormal_behavioral_response	1.50224826
30	MP0009046_muscle_twitch	1.46872061
31	MP0001348_abnormal_lacrimal_gland	1.46236276
32	MP0002736_abnormal_nociception_after	1.45064367
33	MP0005645_abnormal_hypothalamus_physiol	1.44523314
34	MP0002557_abnormal_social/conspecific_i	1.43662533
35	MP0002272_abnormal_nervous_system	1.43594065
36	MP0005379_endocrine/exocrine_gland_phen	1.42491578
37	MP0005670_abnormal_white_adipose	1.40716634
38	MP0002161_abnormal_fertility/fecundity	1.35843725
39	MP0002837_dystrophic_cardiac_calcinosis	1.34789573
40	MP0008995_early_reproductive_senescence	1.31354648
41	MP0006072_abnormal_retinal_apoptosis	1.31053734
42	MP0002572_abnormal_emotion/affect_behav	1.29138557
43	MP0004142_abnormal_muscle_tone	1.28364174
44	MP0002938_white_spotting	1.26985039
45	MP0003136_yellow_coat_color	1.26069541
46	MP0001986_abnormal_taste_sensitivity	1.24254379
47	MP0004133_heterotaxia	1.23552166
48	MP0001501_abnormal_sleep_pattern	1.23400563
49	MP0001145_abnormal_male_reproductive	1.23105468
50	MP0002160_abnormal_reproductive_system	1.22681928
51	MP0000653_abnormal_sex_gland	1.21851848
52	MP0002733_abnormal_thermal_nociception	1.20355187
53	MP0000569_abnormal_digit_pigmentation	1.18360179
54	MP0001984_abnormal_olfaction	1.17790884
55	MP0002067_abnormal_sensory_capabilities	1.17664165
56	MP0000427_abnormal_hair_cycle	1.15602329
57	MP0002234_abnormal_pharynx_morphology	1.12907887
58	MP0005389_reproductive_system_phenotype	1.10039484
59	MP0005646_abnormal_pituitary_gland	1.09714967
60	MP0001963_abnormal_hearing_physiology	1.07146108
61	MP0005084_abnormal_gallbladder_morpholo	1.06707773
62	MP0001905_abnormal_dopamine_level	1.03999236
63	MP0002928_abnormal_bile_duct	1.03258535
64	MP0001970_abnormal_pain_threshold	1.02955817
65	MP0000631_abnormal_neuroendocrine_gland	1.02342061
66	MP0005423_abnormal_somatic_nervous	0.99673618
67	MP0005332_abnormal_amino_acid	0.99324408
68	MP0000026_abnormal_inner_ear	0.97828222
69	MP0001440_abnormal_grooming_behavior	0.95792707
70	MP0003879_abnormal_hair_cell	0.95295733
71	MP0004885_abnormal_endolymph	0.94395386
72	MP0001919_abnormal_reproductive_system	0.93158991
73	MP0003635_abnormal_synaptic_transmissio	0.91732879
74	MP0008875_abnormal_xenobiotic_pharmacok	0.91678423
75	MP0001529_abnormal_vocalization	0.91632410
76	MP0002063_abnormal_learning/memory/cond	0.91326375
77	MP0002064_seizures	0.90893970
78	MP0000049_abnormal_middle_ear	0.90260095
79	MP0003137_abnormal_impulse_conducting	0.89950936
80	MP0002229_neurodegeneration	0.89919148
81	MP0010386_abnormal_urinary_bladder	0.87491533
82	MP0002282_abnormal_trachea_morphology	0.85182048
83	MP0003121_genomic_imprinting	0.83871832
84	MP0005310_abnormal_salivary_gland	0.83157874
85	MP0002638_abnormal_pupillary_reflex	0.83036411
86	MP0005167_abnormal_blood-brain_barrier	0.82340158
87	MP0000955_abnormal_spinal_cord	0.81400053
88	MP0000230_abnormal_systemic_arterial	0.81064005
89	MP0002734_abnormal_mechanical_nocicepti	0.79499820
90	MP0005386_behavior/neurological_phenoty	0.79341846
91	MP0004924_abnormal_behavior	0.79341846
92	MP0002184_abnormal_innervation	0.79082850
93	MP0002822_catalepsy	0.77614225
94	MP0008775_abnormal_heart_ventricle	0.77276425
95	MP0001765_abnormal_ion_homeostasis	0.75616631
96	MP0001293_anophthalmia	0.75278343
97	MP0000372_irregular_coat_pigmentation	0.74016528
98	MP0004085_abnormal_heartbeat	0.73979483
99	MP0005195_abnormal_posterior_eye	0.72772273
100	MP0002752_abnormal_somatic_nervous	0.72674741

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	5.09580035
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.53385589
3	Absent/shortened dynein arms (HP:0200106)	4.53385589
4	Pancreatic cysts (HP:0001737)	4.01796787
5	Tubulointerstitial nephritis (HP:0001970)	3.98375762
6	Nephronophthisis (HP:0000090)	3.87838034
7	Attenuation of retinal blood vessels (HP:0007843)	3.69181176
8	Abnormal respiratory motile cilium morphology (HP:0005938)	3.65562872
9	Abnormal respiratory epithelium morphology (HP:0012253)	3.65562872
10	Pancreatic fibrosis (HP:0100732)	3.64127830
11	Abnormal ciliary motility (HP:0012262)	3.53986911
12	Molar tooth sign on MRI (HP:0002419)	3.49976267
13	Abnormality of midbrain morphology (HP:0002418)	3.49976267
14	Severe visual impairment (HP:0001141)	3.46380740
15	True hermaphroditism (HP:0010459)	3.39027576
16	Abnormality of the renal medulla (HP:0100957)	3.35895397
17	Abnormality of macular pigmentation (HP:0008002)	3.24682959
18	Type II lissencephaly (HP:0007260)	3.17954513
19	Abnormal respiratory motile cilium physiology (HP:0012261)	3.13742681
20	Abnormality of the renal cortex (HP:0011035)	3.11676151
21	Bony spicule pigmentary retinopathy (HP:0007737)	3.04589661
22	Abnormal drinking behavior (HP:0030082)	3.03641273
23	Polydipsia (HP:0001959)	3.03641273
24	Congenital stationary night blindness (HP:0007642)	3.01497060
25	Pendular nystagmus (HP:0012043)	2.99492637
26	Progressive cerebellar ataxia (HP:0002073)	2.98167918
27	Abnormal rod and cone electroretinograms (HP:0008323)	2.94451190
28	Cystic liver disease (HP:0006706)	2.82112173
29	Decreased central vision (HP:0007663)	2.64141529
30	Tubular atrophy (HP:0000092)	2.57062409
31	Amelogenesis imperfecta (HP:0000705)	2.52599289
32	Sclerocornea (HP:0000647)	2.51185230
33	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.50617630
34	Polyuria (HP:0000103)	2.46390960
35	Medial flaring of the eyebrow (HP:0010747)	2.43722984
36	Cerebellar dysplasia (HP:0007033)	2.40854489
37	Abnormality of dental color (HP:0011073)	2.40588234
38	Tubulointerstitial abnormality (HP:0001969)	2.28143056
39	Infertility (HP:0000789)	2.27688928
40	Abnormal urine output (HP:0012590)	2.26793656
41	Hypoalbuminemia (HP:0003073)	2.26761738
42	Abnormal albumin level (HP:0012116)	2.26761738
43	Hyperkalemia (HP:0002153)	2.20998097
44	Stage 5 chronic kidney disease (HP:0003774)	2.17776001
45	Inability to walk (HP:0002540)	2.17361549
46	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.14784811
47	Potter facies (HP:0002009)	2.12997545
48	Facial shape deformation (HP:0011334)	2.12997545
49	Optic nerve hypoplasia (HP:0000609)	2.09964588
50	Anencephaly (HP:0002323)	2.09829110
51	Abolished electroretinogram (ERG) (HP:0000550)	2.08096200
52	Impulsivity (HP:0100710)	2.07245065
53	Renal cortical cysts (HP:0000803)	2.06867003
54	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.04260411
55	Congenital hepatic fibrosis (HP:0002612)	2.03114687
56	Genetic anticipation (HP:0003743)	2.02887653
57	Male pseudohermaphroditism (HP:0000037)	1.96458565
58	Hyperventilation (HP:0002883)	1.96394143
59	Birth length less than 3rd percentile (HP:0003561)	1.96340786
60	Large for gestational age (HP:0001520)	1.94587711
61	Abnormality of renal excretion (HP:0011036)	1.94056360
62	Increased corneal curvature (HP:0100692)	1.91547302
63	Keratoconus (HP:0000563)	1.91547302
64	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.91432271
65	Gait imbalance (HP:0002141)	1.87724840
66	Lissencephaly (HP:0001339)	1.86854103
67	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85224549
68	Retinal dysplasia (HP:0007973)	1.84958342
69	Rhinitis (HP:0012384)	1.84838336
70	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.82894491
71	Hypoplastic ischia (HP:0003175)	1.82742645
72	Postaxial foot polydactyly (HP:0001830)	1.82581477
73	Occipital encephalocele (HP:0002085)	1.82451092
74	Congenital sensorineural hearing impairment (HP:0008527)	1.81543101
75	Decreased circulating renin level (HP:0003351)	1.80776960
76	Azoospermia (HP:0000027)	1.77984450
77	Congenital primary aphakia (HP:0007707)	1.77207599
78	Ectopic kidney (HP:0000086)	1.73859995
79	Patellar aplasia (HP:0006443)	1.73822475
80	Truncal obesity (HP:0001956)	1.72488456
81	Cone-rod dystrophy (HP:0000548)	1.71141486
82	Dyskinesia (HP:0100660)	1.70641326
83	Abnormality of the ileum (HP:0001549)	1.69523243
84	Renovascular hypertension (HP:0100817)	1.68922144
85	Genital tract atresia (HP:0001827)	1.68577175
86	Gaze-evoked nystagmus (HP:0000640)	1.68389768
87	Concave nail (HP:0001598)	1.68143358
88	Aplasia/Hypoplasia of the patella (HP:0006498)	1.67491527
89	Vaginal atresia (HP:0000148)	1.64703407
90	Absent thumb (HP:0009777)	1.63311974
91	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.62649677
92	Abnormality of alanine metabolism (HP:0010916)	1.62649677
93	Hyperalaninemia (HP:0003348)	1.62649677
94	Sloping forehead (HP:0000340)	1.62486160
95	Anterior segment dysgenesis (HP:0007700)	1.62308891
96	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.60531239
97	Abnormality of potassium homeostasis (HP:0011042)	1.60157909
98	Abnormal spermatogenesis (HP:0008669)	1.59397693
99	Abnormality of the pons (HP:0007361)	1.59214773
100	Absent speech (HP:0001344)	1.58313391

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	5.98030273
2	INSRR	4.24734236
3	FRK	3.98141536
4	PNCK	3.18409365
5	BMPR1B	2.73585426
6	MAP4K2	2.61220886
7	WNK4	2.61116146
8	ADRBK2	2.58115525
9	PLK2	2.55428164
10	TLK1	2.21383347
11	ZAK	2.20995476
12	WNK3	2.20049124
13	PINK1	2.15182828
14	NUAK1	1.84460023
15	BRD4	1.60477602
16	GRK1	1.58599117
17	CAMK1G	1.51612929
18	CASK	1.49772660
19	MAPK15	1.44593450
20	MAPK13	1.36277181
21	STK38L	1.36069365
22	MAP3K4	1.30368714
23	STK39	1.25879224
24	ACVR1B	1.24496579
25	TAOK3	1.18144853
26	PRKD3	1.16408868
27	TRIM28	1.14479666
28	PTK2B	1.09864657
29	PIK3CG	1.09257948
30	MARK1	1.03493943
31	DAPK2	1.03253523
32	MKNK2	1.01983547
33	STK38	0.98780716
34	TESK1	0.97567525
35	WNK1	0.93613480
36	TNIK	0.93597763
37	CAMK1D	0.93329736
38	PRKCG	0.93205960
39	NEK2	0.90981035
40	PAK3	0.89891992
41	OXSR1	0.89128266
42	PIK3CA	0.86264900
43	SIK2	0.84569262
44	MAP2K2	0.82544161
45	NEK6	0.80510615
46	VRK1	0.79497684
47	TXK	0.79108976
48	MAP2K7	0.74380833
49	CAMKK2	0.73902602
50	TIE1	0.72368290
51	PRKCE	0.71055196
52	PRKCH	0.70931961
53	MUSK	0.70107915
54	CAMK1	0.67581666
55	ADRBK1	0.66166667
56	DDR2	0.65847589
57	DYRK2	0.62857364
58	TYRO3	0.61883122
59	NTRK2	0.60741549
60	PLK1	0.57065661
61	CDK3	0.56880984
62	NTRK3	0.55994137
63	IKBKB	0.54019299
64	BRSK2	0.53496571
65	TGFBR1	0.52498879
66	PDK1	0.52132878
67	WEE1	0.51098240
68	PKN1	0.51093590
69	PRKAA2	0.50724795
70	PRKD2	0.50438951
71	NME1	0.48180343
72	FGFR2	0.47945934
73	PHKG2	0.46201372
74	PHKG1	0.46201372
75	STK16	0.45564200
76	RPS6KA5	0.44759353
77	PRKACA	0.44621305
78	PRKCZ	0.44263808
79	PRKCQ	0.43886021
80	PRKG1	0.43084605
81	CAMK2A	0.42939465
82	VRK2	0.42484400
83	PRKAA1	0.40381609
84	PDPK1	0.38654556
85	CHUK	0.34283295
86	RPS6KA6	0.33897727
87	DYRK1B	0.33732513
88	CAMK4	0.33281666
89	PASK	0.33039076
90	CSNK1A1	0.31962910
91	CSNK1D	0.31591036
92	ATM	0.31039600
93	SGK494	0.30591102
94	SGK223	0.30591102
95	CDK1	0.28929659
96	UHMK1	0.28459016
97	AKT3	0.28291293
98	GSK3B	0.28233768
99	CHEK2	0.28124250
100	ERBB2	0.27574354

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.87730904
2	Phototransduction_Homo sapiens_hsa04744	2.96180382
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.69812223
4	Butanoate metabolism_Homo sapiens_hsa00650	2.60143858
5	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.50714242
6	Olfactory transduction_Homo sapiens_hsa04740	2.45180955
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.39744140
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.32721764
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.31486895
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.26882055
11	Nicotine addiction_Homo sapiens_hsa05033	2.20677612
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.18990767
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.97480514
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.96034907
15	Homologous recombination_Homo sapiens_hsa03440	1.89163985
16	Taste transduction_Homo sapiens_hsa04742	1.83632787
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.76014253
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.75739242
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.71665129
20	Basal transcription factors_Homo sapiens_hsa03022	1.71044203
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.62449612
22	Caffeine metabolism_Homo sapiens_hsa00232	1.61334721
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.54987662
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.54264409
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.37463505
26	Oxidative phosphorylation_Homo sapiens_hsa00190	1.36300684
27	ABC transporters_Homo sapiens_hsa02010	1.34181064
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.32263042
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.31153711
30	Morphine addiction_Homo sapiens_hsa05032	1.30933088
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24729275
32	One carbon pool by folate_Homo sapiens_hsa00670	1.23866032
33	RNA polymerase_Homo sapiens_hsa03020	1.13877315
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.10695101
35	Fat digestion and absorption_Homo sapiens_hsa04975	1.09206257
36	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.07875043
37	RNA transport_Homo sapiens_hsa03013	1.03708831
38	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.01847381
39	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.01802057
40	Insulin secretion_Homo sapiens_hsa04911	0.99044805
41	Propanoate metabolism_Homo sapiens_hsa00640	0.96836365
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94018967
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.93307860
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91093626
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.91059466
46	GABAergic synapse_Homo sapiens_hsa04727	0.90995270
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89586244
48	Huntingtons disease_Homo sapiens_hsa05016	0.88653394
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.88452926
50	Serotonergic synapse_Homo sapiens_hsa04726	0.87411470
51	RNA degradation_Homo sapiens_hsa03018	0.84111648
52	Retinol metabolism_Homo sapiens_hsa00830	0.83768811
53	Fatty acid degradation_Homo sapiens_hsa00071	0.82280986
54	Parkinsons disease_Homo sapiens_hsa05012	0.82267679
55	Type II diabetes mellitus_Homo sapiens_hsa04930	0.80724822
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79880200
57	Peroxisome_Homo sapiens_hsa04146	0.76781198
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75369698
59	Circadian entrainment_Homo sapiens_hsa04713	0.72483893
60	Calcium signaling pathway_Homo sapiens_hsa04020	0.71586426
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.71170819
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70512980
63	Graft-versus-host disease_Homo sapiens_hsa05332	0.70162539
64	Allograft rejection_Homo sapiens_hsa05330	0.69551029
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.68947986
66	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.68499566
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67959239
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67629766
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.67595860
70	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.66783708
71	Sulfur relay system_Homo sapiens_hsa04122	0.65436640
72	Purine metabolism_Homo sapiens_hsa00230	0.64949762
73	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64761932
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59399083
75	Salivary secretion_Homo sapiens_hsa04970	0.58951606
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53828813
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.53368098
78	Amphetamine addiction_Homo sapiens_hsa05031	0.52647352
79	Asthma_Homo sapiens_hsa05310	0.50308640
80	Metabolic pathways_Homo sapiens_hsa01100	0.50255079
81	cAMP signaling pathway_Homo sapiens_hsa04024	0.49769363
82	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.49400411
83	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.47910944
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.43650760
85	Mineral absorption_Homo sapiens_hsa04978	0.43416990
86	Alzheimers disease_Homo sapiens_hsa05010	0.42621403
87	Regulation of autophagy_Homo sapiens_hsa04140	0.41227500
88	Pyrimidine metabolism_Homo sapiens_hsa00240	0.38396427
89	Folate biosynthesis_Homo sapiens_hsa00790	0.38045645
90	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37683326
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32774113
92	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.32108448
93	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31970014
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31584336
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.30888595
96	Histidine metabolism_Homo sapiens_hsa00340	0.30229787
97	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.30032804
98	Protein export_Homo sapiens_hsa03060	0.29044686
99	Nucleotide excision repair_Homo sapiens_hsa03420	0.28111544
100	Renin secretion_Homo sapiens_hsa04924	0.27215203

LRRC37A9P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »